Wuriyanghai Yimin 烏日揚海伊敏

Researcher Number	10824956
Affiliation (Current)	2025: 京都大学, 医学研究科, 研究員
Affiliation (based on the past Project Information) *help	2019 – 2020: 京都大学, 医学研究科, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 致死性遺伝性不整脈 / ラミン関連心筋症 / 遺伝子不整脈 / QT延長症候群 / ゲノム編集 / 疾患モデル / 心筋症 / 突然死 / 遺伝性不整脈 / 遺伝子 / 心臓突然死 / iPS細胞 / 不整脈

iPS cell-based modeling of inherited arrhythmia disorders using the latest genome editing technologyPrincipal Investigator
- Principal Investigator
  
  Wuriyanghai Yimin
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kyoto University

All 2020 2019

All Journal Article Presentation

[Journal Article] Propranolol Attenuates Late Sodium Current in a Long QT Syndrome Type 3-Human Induced Pluripotent Stem Cell Model2020
- Author(s)
  Hirose Sayako、Makiyama Takeru、Melgari Dario、Yamamoto Yuta、Wuriyanghai Yimin、Yokoi Fumika、Nishiuchi Suguru、Harita Takeshi、Hayano Mamoru、Kohjitani Hirohiko、Gao Jingshan、Kashiwa Asami、Nishikawa Misato、Wu Jie、Yoshimoto Jun、Chonabayashi Kazuhisa、Ohno Seiko、Yoshida Yoshinori、Horie Minoru、Kimura Takeshi
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 8 Pages: 761-761
- DOI
  10.3389/fcell.2020.00761
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-18H02808, KAKENHI-PROJECT-18K07875, KAKENHI-PROJECT-19K17595, KAKENHI-PROJECT-17H04176
[Journal Article] Expertise ヒトiPS細胞由来心筋細胞の電気生理学 (特集心臓電気生理を理解して不整脈診療に活かす) iPS cell-derived cardiomyocytes as a platform for research on inherited arrhythmias2019
- Author(s)
  堀江稔,Wuriyanghai Yimin,牧山武
- Journal Title
  
  Heart view
  
  Volume: 23 Pages: 578-585
- Data Source
  KAKENHI-PROJECT-19K17595
[Journal Article] Phenotype-Based High-Throughput Classification of Long QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells2019
- Author(s)
  Yoshinaga Daisuke、Baba Shiro、Makiyama Takeru、Shibata Hirofumi、Hirata Takuya、Akagi Kentaro、Matsuda Koichi、Kohjitani Hirohiko、Wuriyanghai Yimin、Umeda Katsutsugu、Yamamoto Yuta、Conklin Bruce R.、Horie Minoru、Takita Junko、Heike Toshio
- Journal Title
  
  Stem Cell Reports
  
  Volume: 13 Issue: 2 Pages: 394-404
- DOI
  10.1016/j.stemcr.2019.06.007
- NAID
  120006786948
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08538, KAKENHI-PROJECT-19K17595, KAKENHI-PROJECT-17H04224, KAKENHI-PROJECT-17K09495, KAKENHI-PROJECT-18K19467, KAKENHI-PROJECT-18K15847, KAKENHI-PROJECT-18H02808
[Presentation] Inhibition of Late Sodium Current Attenuates Prolonged Action Potential Durations in CACNA1C-E1115K iPS Cell Model with Disrupted Cav1.2 ion Selectivity2020
- Author(s)
  Asami Kashiwa, Takeru Makiyama, Hirohiko Kohjitani, Thomas Maurissen, Yimin Wuriyanghai, et al.
- Organizer
  第14回日本循環器学会基礎研究フォーラム（BCVR2020）
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Inhibition of Late Sodium Current Attenuates Prolonged Action Potential Durations in CACNA1C-E1115K iPS Cell Model with Disrupted Cav1.2 ion Selectivity2020
- Author(s)
  Asami Kashiwa, Takeru Makiyama, Hirohiko Kohjitani, Thomas Maurissen, Yimin Wuriyanghai, Yuta Yamamoto, Jingshan Gao, Hai Huang, Tomohiko Imamura, Takanori Aizawa, Taisuke Ishikawa, Seiko Ohno, Futoshi Toyoda, Seiich Sato, Kazuhiro Takahashi, Knut Woltjen, Minoru Horie, Naomasa Makita, Takeshi Kimura
- Organizer
  The Heart Rhythm Society's Annual Scientific Sessions 2020 (HRS2020)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Human Induced Pluripotent Stem Cell Model of CACNA1C-E1115K which Impairs Ion Selectivity of the Cardiac L-type Calcium Channel2020
- Author(s)
  Asami Kashiwa, Takeru Makiyama, Thomas Maurissen, Hirohiko Kohjitani, Yimin Wuriyanghai, Yuta Yamamoto, Jungshan Gao, Huang Hai, Tomohiko Imamura, Takanori Aizawa, Taisuke Ishikawa, Seiko Ohno, Futoshi Toyoda, Seiich Sato, Kazuhiro Takahashi, Knut Woltjen, Minoru Horie, Naomasa Makita, Takeshi Kimura.
- Organizer
  第84回日本循環器学会学術集会（JCS2020）
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] 患者由来iPS細胞モデルを用いたCav 1.2イオン選択性を障害するCACNA1C-E1115K変異がQT延長症候群、Brugada症候群を発症するメカニズムの解析2020
- Author(s)
  Asami Kashiwa, Takeru Makiyama, Hirohiko Kohjitani, Thomas Maurissen, Yimin Wuriyanghai, Yuta Yamamoto, Jiungshan Gao, Huang Hai, Tomohiko Imamura, Takanori Aizawa, Taisuke Ishikawa, Seiko Ohno, Futoshi Toyoda, Seiich Sato, Kazuhiro Takahashi, Knut Woltjen, Minoru Horie, Naomasa Makita, Takeshi Kimura.
- Organizer
  第97回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Clinical and genetic aspects of pediatric Brugada syndrome2020
- Author(s)
  Tomohiko Imamura, Takeru Makiyama, Hai Huang, Takanori Aizawa, Jingshan Gao, Asami Kashiwa, Yimin Wuriyanghai, Yuta Yamamoto, Yasuhiko Kohjitani, Koichi Kato, Seiko Ohno, Naokata Sumitomo, Minoru Horie.
- Organizer
  European Society of Cardiology (ESC) Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Preclinical Proof-of-Concept Study: Antisense-mediated Knockdown of CALM as a Therapeutic Strategy for Calmodulinopathy2020
- Author(s)
  Yuta Yamamoto, Takeru Makiyama, Yoshiki Kondo, Yusuke Iriyama, Ryutarou Ishikawa, Yimin Wuriyanghai, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Huang Hai, Takanori Aizawa, Tomohiko Imamura, Taisuke Ishikawa, Yoshinori Yoshida, Seiko Ohno, Minoru Horie, Naomasa Makita, Takeshi Kimura
- Organizer
  European Society of Cardiology (ESC) Congress 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] CALM2-N98S Mutation Associated with Long QT Syndrome Impaired the Response of KCNQ1 Channel to Beta-adrenergic Stimulation in Human iPSC-derived Cardiomyocytes.2020
- Author(s)
  Yuta Yamamoto, Takeru Makiyama, Yimin Wuriyanghai, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Huang Hai, Takanori Aizawa, Tomohiko Imamura, Taisuke Ishikawa, Hideki Motomura, Yoshinori Yoshida, Seiko Ohno, Minoru Horie, Naomasa Makita, Takeshi Kimura.
- Organizer
  第84回日本循環器学会学術集会（JCS2020）
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Algorithmic Auto-Recreation System of hiPSC-CMs Simulation and Prediction of Drug Testing2019
- Author(s)
  Hirohiko Kohjitani, Shigeya Kouda, Yukiko Himeno, Takeru Makiyama, Hai Huang, Jingshan Gao, Asami Kashiwa, Yimin Wuriyanghai, Daisuke Yoshinaga, Takeshi Kimura, Akira Amano.
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Morphological and electrophysiological characterization of homozygous lamin A/C knockout human induced-pluripotent stem cell-derived cardiomyocytes. American Heart Association Scientific Sessions 20192019
- Author(s)
  Yimin Wuriyanghai, Takeru Makiyama, Yuta Yamamoto, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Hai Huang, Takanori Aizawa, Tomohiko Imamura, Seiko Ohno, Minoru Horie, Takeshi Kimura
- Organizer
  American Heart Association Scientific Sessions 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Modeling Overlapping Phenotypes of Long-QT and Brugada Syndrome with CACNA1C-E1115K that Alters Ion Selectivity of the Cardiac L-Type Calcium Channel Using Induced Pluripotent Stem Cells.2019
- Author(s)
  Asami Kashiwa, Takeru Makiyama, Hirohiko Kohjitani, Yimin Wuriyanghai, Yuta Yamamoto, Jingshan Gao, Hai Huang, Taisuke Ishikawa, Seiko Ohno, Futoshi Toyoda, Seiichi Sato, Minoru Horie, Naomasa Makita, Takeshi Kimura
- Organizer
  第66回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Patients characteristics of idiopathic ventricular fibrillation carrying SCN5A mutations without Brugada or long QT syndrome.2019
- Author(s)
  Takanori Aizawa, Takeru Makiyama, Hai Huang, Tomohiko Imamura, JingShan Gao, Yimin Wuriyanghai, Takeru Makiyama, Yuta Yamamoto, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Hai Huang, Wuriyanghai Yimin, Hirohiko Kohjitani, Yuta Yamamoto, Seiko Ohno, Minoru Horie
- Organizer
  12th Asia Pacific Heart Rhythm Society Scientific Session (APHRS2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Structural Insights into Catecholaminergic Polymorphic Ventricular Tachycardia-associated RyR2 Mutant Channels using a Three-dimensional in Silico Model.2019
- Author(s)
  Jingshan Gao, Takeru Makiyama, Seiko Ohno, Yuta Yamamoto, Yimin Wuriyanghai, Hirohiko Kohjitani, Asami Kashiwa, Hai Huang, Kouichi Katou, Minoru Horie, Takeshi Kimura.
- Organizer
  第66回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Structural Insights into Catecholaminergic Polymorphic Ventricular Tachycardia-associated RyR2 Mutant Channels using a Three-dimensional In Silico Model.2019
- Author(s)
  J. Gao, T. Makiyama, S. Ohno, Y. Yamamoto, Y. Wuriyanghai, H. Kohjitani, A. Kashiwa, H. Huang, K. Katou, M. Horie, T. Kimura.
- Organizer
  European Society of Cardiology Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Automatic Computational Action Potential Analyzing System Enables Accurate Drug Response Interpretation and Prediction in Human Induced Pluripotent Stem Cell-derived Cardiomyocytes2019
- Author(s)
  Hirohiko Kohjitani, Shigeya Kouda, Yukiko Himeno, Takeru Makiyama, Asami Kashiwa, Yimin Wuriyanghai, Yuta Yamamoto, Minoru Horie, Takeshi Kimura, Akinori Noma, Akira Amano.
- Organizer
  40th Heart Rhythm Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Response of KCNQ1 to Adrenergic Stimulation was Impaired in Human Induced Pluripotent Stem Cell-derived Cardiomyocytes Carrying a CALM2-N98S Mutation Associated with Long QT Syndrome.2019
- Author(s)
  Yuta Yamamoto, Takeru Makiyama, Yimin Wuriyanghai, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Huang Hai, Takanori Aizawa, Tomohiko Imamura, Taisuke Ishikawa, Seiko Ohno, Kazuhisa Chonabayashi, Hideki Motomura, Yoshinori Yoshida, Minoru Horie, Naomasa Makita, Takeshi Kimura
- Organizer
  12th Asia Pacific Heart Rhythm Society Scientific Session (APHRS2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Complex aberrant splicing in the induce pluripotent stem cell-derived cardiomyocytes from a patient with long-QT syndrome carrying KCNQ1-A344Aspl mutation.2019
- Author(s)
  Wuriyanghai Y, Makiyama T, Sasaki K, Kamakura T, Yamamoto Y, Hayano M, Harita T, Nishiuchi S, Chen J, Kohjitani H, Hirose S, Yokoi F, Gao J, Chonabayashi K, Watanabe K, Ohno S, Yoshida Y, Kimura T, Horie M
- Organizer
  第66回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] KCNQ1 Channel Dysfunction in human induced pluripotent stem cell-derived cardiomyocytes carrying a CALM2-N98S mutation associated with long QT syndrome2019
- Author(s)
  Yuta Yamamoto, Takeru Makiyama, Yimin Wuriyanghai, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Huang Hai, Takanori Aizawa, Tomohiko Imamura, Taisuke Ishikawa, Seiko Ohno, Kazuhisa Chonabayashi, Hideki Motomura, Yoshinori Yoshida, Minoru Horie, Naomasa Makita, Takeshi Kimura
- Organizer
  American Heart Association Scientific Sessions 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Overlapping Sick Sinus Syndrome Associated with SCN5A Mutations in Patients with Brugada Syndrome2019
- Author(s)
  Asami Kashiwa, Takeru Makiyama, Seiko Ohno, Hisaaki Aoki, Hirohiko Kohjitani Yimin Wuriyanghai, Yuta Yamamoto, Jingshan Gao, Huang Hai, Minoru Horie, Takeshi Kimura.
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Single Cell Electrophysiological Analysis of iPS Cell-derived Cardiomyocytes Generated from Long-QT Syndrome Patients Carrying a CALM2 Mutation Using a Membrane Potential Imaging System.2019
- Author(s)
  Yuta Yamamoto, Takeru Makiyama(代発表), Yimin Wuriyanghai, Hirohiko Kohjitani, Sayako Hirose, Jingshan Gao, Asami Kashiwa, Huang Hai, Taisuke Ishikawa, Seiko Ohno, Kazuhisa Chonabayashi, Kenji Suda, Yoshinori Yoshida, Minoru Horie, Naomasa Makita, Takeshi Kimura,
- Organizer
  第66回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Algorithmic Auto-Recreation System of hiPSC-CMs Simulation and Prediction of Drug Testing.2019
- Author(s)
  Hirohiko Kohjitani, Shigeya Kouda, Yukiko Himeno, Takeru Makiyama, Asami Kashiwa, Yimin Wuriyanghai, Yuta Yamamoto, Minoru Horie, Takeshi Kimura, Akinori Noma, Akira Amano
- Organizer
  12th Asia Pacific Heart Rhythm Society Scientific Session (APHRS2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Phenotype-based High-throughput Classification of Long-QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells.2019
- Author(s)
  Daisuke Yoshinaga, Shiro Baba, Takeru Makiyama, Hirofumi Shibata, Takuya Hirata, Kentaro Akagi, Koichi Matsuda, Hirohiko Kohjitani, Yimin Wuriyanghai, Katsutsugu Umeda, Yuta Yamamoto, Bruce R. Conklin, Minoru Horie, Junko Takita, Toshio Heike.
- Organizer
  第66回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Algorithmic Auto-Recreation System of hiPSC-CMs Simulation and Prediction of Drug Testing.2019
- Author(s)
  Hirohiko Kohjitani, Shigeya Kouda, Yukiko Himeno, Takeru Makiyama, Hai Huang, Jingshan Gao, Asami Kashiwa, Yimin Wuriyanghai, Daisuke Yoshinaga, Takeshi Kimura, Akira Amano.
- Organizer
  第66回日本不整脈心電学会学術大会
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Modeling Overlap Syndrome Of Long QT And Brugada Syndrome Associated With CACNA1C-E1115K Which Alters Ion Selectivity With Induced Pluripotent Stem Cells2019
- Author(s)
  Asami Kashiwa, Takeru Makiyama, Hirohiko Kohjitani, Yimin Wuriyanghai, Yuta Yamamoto, Gao Jungshan, Hai Huang, Taisuke Ishikawa, Seiko Ohno, Futoshi Toyoda, , Seiichi Sato, Minoru Horie , Naomasa Makita, Takeshi Kimura.
- Organizer
  40th Heart Rhythm Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17595
[Presentation] Three-Dimensional Structural Analysis of Mutant Ryanodine Receptor Type 2 Channels Associated with Catecholaminergic Polymorphic Ventricular Tachycardia.2019
- Author(s)
  Jingshan Gao, Takeru Makiyama, Seiko Ohno, Yuta Yamamoto, Yimin Wuriyanghai, Hirohiko Kohjitani, Asami Kashiwa, Minoru Horie, Takeshi Kimura.
- Organizer
  第83回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17595

1. MAKIYAMA Takeru

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Wuriyanghai Yimin 烏日揚海 伊敏

Research Projects

Research Products

Co-Researchers

iPS cell-based modeling of inherited arrhythmia disorders using the latest genome editing technologyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Propranolol Attenuates Late Sodium Current in a Long QT Syndrome Type 3-Human Induced Pluripotent Stem Cell Model2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expertise ヒトiPS細胞由来心筋細胞の電気生理学 (特集 心臓電気生理を理解して不整脈診療に活かす) iPS cell-derived cardiomyocytes as a platform for research on inherited arrhythmias2019

Author(s)

Journal Title

Data Source

[Journal Article] Phenotype-Based High-Throughput Classification of Long QT Syndrome Subtypes Using Human Induced Pluripotent Stem Cells2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] Inhibition of Late Sodium Current Attenuates Prolonged Action Potential Durations in CACNA1C-E1115K iPS Cell Model with Disrupted Cav1.2 ion Selectivity2020

Author(s)

Organizer

Data Source

[Presentation] Inhibition of Late Sodium Current Attenuates Prolonged Action Potential Durations in CACNA1C-E1115K iPS Cell Model with Disrupted Cav1.2 ion Selectivity2020

Author(s)

Organizer

Data Source

[Presentation] Human Induced Pluripotent Stem Cell Model of CACNA1C-E1115K which Impairs Ion Selectivity of the Cardiac L-type Calcium Channel2020

Author(s)

Organizer

Data Source

[Presentation] 患者由来iPS細胞モデルを用いたCav 1.2イオン選択性を障害するCACNA1C-E1115K変異がQT延長症候群、Brugada症候群を発症するメカニズムの解析2020

Author(s)

Organizer

Data Source

[Presentation] Clinical and genetic aspects of pediatric Brugada syndrome2020

Author(s)

Organizer

Data Source

[Presentation] Preclinical Proof-of-Concept Study: Antisense-mediated Knockdown of CALM as a Therapeutic Strategy for Calmodulinopathy2020

Author(s)

Organizer

Data Source

[Presentation] CALM2-N98S Mutation Associated with Long QT Syndrome Impaired the Response of KCNQ1 Channel to Beta-adrenergic Stimulation in Human iPSC-derived Cardiomyocytes.2020

Author(s)

Organizer

Data Source

[Presentation] Algorithmic Auto-Recreation System of hiPSC-CMs Simulation and Prediction of Drug Testing2019

Author(s)

Organizer

Data Source

[Presentation] Morphological and electrophysiological characterization of homozygous lamin A/C knockout human induced-pluripotent stem cell-derived cardiomyocytes. American Heart Association Scientific Sessions 20192019

Author(s)

Organizer

Data Source

[Presentation] Modeling Overlapping Phenotypes of Long-QT and Brugada Syndrome with CACNA1C-E1115K that Alters Ion Selectivity of the Cardiac L-Type Calcium Channel Using Induced Pluripotent Stem Cells.2019

Author(s)

Organizer

Data Source

[Presentation] Patients characteristics of idiopathic ventricular fibrillation carrying SCN5A mutations without Brugada or long QT syndrome.2019

Author(s)

Organizer

Data Source

[Presentation] Structural Insights into Catecholaminergic Polymorphic Ventricular Tachycardia-associated RyR2 Mutant Channels using a Three-dimensional in Silico Model.2019

Author(s)

Organizer

Data Source

[Presentation] Structural Insights into Catecholaminergic Polymorphic Ventricular Tachycardia-associated RyR2 Mutant Channels using a Three-dimensional In Silico Model.2019

Author(s)

Organizer

Data Source

[Presentation] Automatic Computational Action Potential Analyzing System Enables Accurate Drug Response Interpretation and Prediction in Human Induced Pluripotent Stem Cell-derived Cardiomyocytes2019

Author(s)

Organizer

Wuriyanghai Yimin 烏日揚海伊敏

[Journal Article] Expertise ヒトiPS細胞由来心筋細胞の電気生理学 (特集心臓電気生理を理解して不整脈診療に活かす) iPS cell-derived cardiomyocytes as a platform for research on inherited arrhythmias2019