Takeshita Atsuro 竹下敦郎

Researcher Number	10830490
Other IDs
Affiliation (Current)	2025: 三重大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2021 – 2025: 三重大学, 医学部附属病院, 助教 2020 – 2022: 三重大学, 医学系研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Basic Section 53040:Nephrology-related Except Principal Investigator Basic Section 53030:Respiratory medicine-related / Basic Section 54040:Metabolism and endocrinology-related / Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 細菌叢 / アポトーシス / 膵β細胞 / 糖尿病 / 糖尿病性腎症 / 慢性腎臓病 / 細菌由来ペプチド / 肺線維症 / ヒト組換えトロンボモジュリン / トロンボモジュリン / 糖尿病性腎臓病 / 腎線維症 … More Except Principal Investigator … More 細菌叢 / コリシン / 急性肺障害 / corisin / 細胞死 / 2型糖尿病 / ペプチド / 細胞老化 / dysbiosis / 慢性炎症 / COPD / 急性肺炎 / SARS-CoV-2 / サイトカイン / 凝固制御機構 / 凝固系 / マウスモデル / COVID-19 / 肝線維化 / 肺疾患 / ムチン過剰発現 / ブレオマイシン / 成長因子 / 細胞死誘導因子 / アポトーシス / TGFΒ1 / MUC5Bタンパク / トランスジェニックマウス / 抗コリシン抗体 / TGFbeta1 / 細胞死因子 / 肺内細菌叢 / 急性増悪 / 予後 / 抗線維化剤 / MUC5B / ムチン / 肺線維症 Less

COPD急性増悪への革新的アプローチ：細菌叢由来細胞死誘導因子阻害剤の効果
- Principal Investigator
  
  GABAZZA CORINA
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Mie University
Elucidation of the mechanism of chronic inflammation induced by dysbiosis in type 2 diabetes mellitus
- Principal Investigator
  
  矢野裕
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Mie University
細菌叢由来ペプチドのNASH肝線維化における意義解明と臨床応用への展開
- Principal Investigator
  
  安間太郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Mie University
トロンボモジュリンによる膵β細胞保護作用の分子機構の解明Principal Investigator
- Principal Investigator
  
  竹下敦郎
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Mie University
Development of a new treatment for COVID-19-related acute lung injury targeting the microbiota-derived peptide corisin
- Principal Investigator
  
  Gabazza Esteban
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Mie University
Suppression of progressive diabetic nephropathy stages by thrombomodulinPrincipal Investigator
- Principal Investigator
  
  Takeshita Atsuro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Mie University
Investigating the role of mucin in pulmonary fibrosis-associated microbiota dysbiosis using MUC5B overexpressing mice
- Principal Investigator
  
  Gabazza Esteban
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Mie University

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Role of microbiota-derived corisin in coagulation activation during SARS-CoV-2 infection.2024
- Author(s)
  Tsuruga T, Fujimoto H, Yasuma T, D'Alessandro-Gabazza CN, Toda M, Ito T, Tomaru A, Saiki H, Okano T, Alhawsawi MAB, Takeshita A, Nishihama K, Takei R, Kondoh Y, Cann I, Gabazza EC, Kobayashi T.
- Journal Title
  
  J Thromb Haemost.
  
  Volume: S1538-7836(24)00118-1. Issue: 7 Pages: 1919-1935
- DOI
  10.1016/j.jtha.2024.02.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15206, KAKENHI-PROJECT-21K16185
[Journal Article] Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression.2023
- Author(s)
  Inoue R, Yasuma T, Fridman D'Alessandro V, Toda M, Ito T, Tomaru A, D'Alessandro-Gabazza CN, Tsuruga T, Okano T, Takeshita A, Nishihama K, Fujimoto H, Kobayashi T, Gabazza EC.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 24(7) Issue: 7 Pages: 6695-6695
- DOI
  10.3390/ijms24076695
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15206, KAKENHI-PROJECT-23K07651, KAKENHI-PROJECT-21K08203
[Journal Article] Inhibition of a Microbiota-Derived Peptide Ameliorates Established Acute Lung Injury2023
- Author(s)
  D'Alessandro Fridman V, D'Alessandro-Gabazza CN, Yasuma T, Toda M, Takeshita A, Tomaru A, Tharavecharak S, Lasisi IO, Hess RY, Nishihama K, Fujimoto H, Kobayashi T, Cann I, Gabazza EC.
- Journal Title
  
  American Journal of Pathology
  
  Volume: 23 Issue: 6 Pages: 740-754
- DOI
  10.1016/j.ajpath.2023.03.003
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08280, KAKENHI-PROJECT-20K08564, KAKENHI-PROJECT-21K16116, KAKENHI-PROJECT-21K16160, KAKENHI-PROJECT-23K15206, KAKENHI-PROJECT-21K08203, KAKENHI-PROJECT-21K16185
[Journal Article] Transforming Growth Factorβ1 Overexpression Is Associated with Insulin Resistance and Rapidly Progressive Kidney Fibrosis under Diabetic Conditions.2022
- Author(s)
  D'Alessandro VF, Takeshita A, Yasuma T, Toda M, D'Alessandro-Gabazza CN, Okano Y, Tharavecharak S, Inoue C, Nishihama K, Fujimoto H, Kobayashi T, Yano Y, Gabazza EC.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 23 Issue: 22 Pages: 146251-19
- DOI
  10.3390/ijms232214265
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08256, KAKENHI-PROJECT-22K08280, KAKENHI-PROJECT-21K16185, KAKENHI-PROJECT-21K16160
[Journal Article] Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis.2022
- Author(s)
  D'Alessandro-Gabazza CN, Yasuma T, Kobayashi T, Toda M, Abdel-Hamid AM, Fujimoto H, Hataji O, Nakahara H, Takeshita A, Nishihama K, Okano T, Saiki H, Okano Y, Tomaru A, D'Alessandro VF, Shiraishi M, Mizoguchi A, Ono R, Ohtsuka J, Fukumura M, Nosaka T, et al. & Gabazza EC
- Journal Title
  
  Nat Commun
  
  Volume: 13 Issue: 1 Pages: 1558-1558
- DOI
  10.1038/s41467-022-29064-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03529, KAKENHI-PROJECT-20K08564, KAKENHI-PROJECT-21K08256, KAKENHI-PROJECT-21K08411, KAKENHI-PROJECT-20K21614, KAKENHI-PROJECT-21K08203, KAKENHI-PROJECT-21K16185, KAKENHI-PROJECT-21K16116, KAKENHI-PROJECT-21K16160
[Journal Article] Protective Role of Recombinant Human Thrombomodulin in Diabetes Mellitus.2021
- Author(s)
  Okano Y, Takeshita A, Yasuma T, Toda M, Nishihama K, Fridman D'Alessandro V, Inoue C, D'Alessandro-Gabazza CN, Kobayashi T, Yano Y, Gabazza EC.
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 9 Pages: 1-13
- DOI
  10.3390/cells10092237
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08256, KAKENHI-PROJECT-21K16185
[Journal Article] A Microbiome-Derived Peptide Induces Apoptosis of Cells from Different Tissues2021
- Author(s)
  Saiki Haruko、Okano Yuko、Yasuma Taro、Toda Masaaki、Takeshita Atsuro、Abdel-Hamid Ahmed M.、Fridman D’Alessandro Valeria、Tsuruga Tatsuki、D’Alessandro-Gabazza Corina N.、Katayama Kan、Sugimoto Masahiko、Fujimoto Hajime、Yamanaka Keiichi、Kobayashi Tetsu、Cann Isaac、Gabazza Esteban C.
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 11 Pages: 2885-2885
- DOI
  10.3390/cells10112885
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08564, KAKENHI-PROJECT-21K08203, KAKENHI-PROJECT-21K16185
[Journal Article] Low-Dose of Intrapulmonary Pirfenidone Improves Human Transforming Growth Factorβ1-Driven Lung Fibrosis2020
- Author(s)
  Okano Tomohito、Kobayashi Tetsu、Yasuma Taro、D’Alessandro-Gabazza Corina N.、Toda Masaaki、Fujimoto Hajime、Nakahara Hiroki、Okano Yuko、Takeshita Atsuro、Nishihama Kota、Saiki Haruko、Tomaru Atsushi、Fridman D’Alessandro Valeria、Ishida Satoru、Sugimoto Hiromi、Takei Yoshiyuki、Gabazza Esteban C.
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 11
- DOI
  10.3389/fphar.2020.593620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08564, KAKENHI-PROJECT-18K08175
[Presentation] Rapidly progressive kidney fibrosis in podocyte specific human TGF-β1 transgenic mice with diabetes2024
- Author(s)
  Atsuro Takeshita, Taro Yasuma, Suphachai Tharavecharak, Valeria D’Alesandro Fridman, Maya Kato, Chisa Inoue, Yuko Okano, Kota Nishihama, Masaaki Toda, Corina N. D'Allesandro-Gabazza, Yutaka Yano2, Esteban C. Gabazza
- Organizer
  第52回日本免疫学会
- Data Source
  KAKENHI-PROJECT-21K16185
[Presentation] 細菌由来ペプチドcorisinがポドサイト，尿細管上皮および血管内皮細胞の細胞死を誘導する2023
- Author(s)
  岡野優子，井上知紗，バレリアフリードマン，竹下敦郎，西濵康太，安間太郎，コリーナガバザ，戸田雅昭，エステバンガバザ，矢野裕
- Organizer
  第67回日本糖尿病学術集会総会
- Data Source
  KAKENHI-PROJECT-21K16185
[Presentation] TGFβ1過剰発現マウスは糖尿病誘発により腎線維化が急速に進行する2023
- Author(s)
  井上知紗，安間太郎，竹下敦郎，岡野優子，西濵康太，ガバザコリーナ，戸田雅昭，上村明，鈴木俊成，矢野裕，ガバザエステバン
- Organizer
  第67回日本糖尿病学術集会総会
- Data Source
  KAKENHI-PROJECT-21K16185
[Presentation] TGFβ1過剰発現糖尿病マウスにおけるインスリン抵抗性の検討2023
- Author(s)
  安間太郎，井上知紗，岡野優子，ガバザコリーナ，竹下敦郎，西濵康太，フリードマンバレリア，上村明，鈴木俊成，戸田雅昭，矢野裕，ガバザエステバン
- Organizer
  第67回日本糖尿病学術集会総会
- Data Source
  KAKENHI-PROJECT-21K16185
[Presentation] ヒト組換えトロンボモジュリンの抗糖尿病作用2022
- Author(s)
  竹下敦郎, 岡野優子, 井上知紗, 西濵康太, 安間太郎, Valeria Fridman, 戸田雅昭,Corina N. D’Alessandro-Gabazza, Esteban Gabazza,　矢野裕
- Organizer
  第65回　日本糖尿病学会
- Data Source
  KAKENHI-PROJECT-21K16185
[Presentation] The protective effect of recombinant thrombomodulin on transforming growth factor 1 induced podocyte injury2022
- Author(s)
  Atsuro Takeshita, Chisa Inoue, Yuko Okano, Kota Nishihama, Taro Yasuma, Valeria Fridman-D'Alessandro, Masaaki Toda, Corina N. D'Alessandro-Gabazza, Yutaka Yano, Esteban C. Gabazza
- Organizer
  第51回　日本免疫学会
- Data Source
  KAKENHI-PROJECT-21K16185
[Presentation] 細菌由来ペプチド corisin がポドサイトのアポトーシスを誘導する2022
- Author(s)
  岡野優子, 井上知紗, 竹下敦郎, 西濵康太, 安間太郎, バレリア・フリードマン, ガバザ・コリナ, 戸田雅昭, 上村明, 鈴木俊成,矢野裕, ガバザ・エステバン
- Organizer
  第37回日本糖尿病合併症学会
- Data Source
  KAKENHI-PROJECT-21K16185
[Presentation] ブドウ球菌由来のアポトーシス促進ペプチドはブレオマイシン誘発肺線維症モデルにおいて慢性期の肺線維化を促進する2022
- Author(s)
  岡野　智仁、Valeria Fridman D’Alessandro、古橋　一樹、大岩　綾香、鶴賀　龍樹、齋木　晴子、藤原　拓海、浅山　健太郎、高橋　佳紀、都丸　敦史、中原　博紀、藤本　源、岡野　優子、竹下　敦郎、安間　太郎、Corina N. D’Alessandro-Gabazza、Esteban C. Gabazza、小林　哲
- Organizer
  第62回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-20K08564
[Presentation] Thrombomodulin suppresses apoptosis of podocytes by activating Akt signal pathway2021
- Author(s)
  Valeria Fridman D'Alessandro, Taro Yasuma, Masaaki Toda, Atsuro Takeshita, Corina D'Alessandro Gabazza, Yuko Okano, Yutaka Yano, Esteban Gabazza
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08564
[Presentation] トロンボモジュリンによる腎細胞保護効果の検証2021
- Author(s)
  竹下敦郎，内田明宏，岡野優子，西濵康太，安間太郎，ガバザコリナ，戸田雅昭，矢野裕，ガバザエステバン
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K16185
[Presentation] microbiome-derived peptide induces apoptosis of cells from different tissues2021
- Author(s)
  Yuko Okano1, 2), Atsuro Takeshita1, 2), Kota Nishihama1, 2), Valeria Fridman1), Taro Yasuma1, 2), Corina Gabazza1) , Masaaki Toda1), Yutaka Yano2), Esteban Gabazza1)
- Organizer
  第50回日本免疫学会
- Data Source
  KAKENHI-PROJECT-21K16185
[Presentation] A microbiome-derived peptide induces apoptosis of cells from different tissues2021
- Author(s)
  Yuko Okano1, Atsuro Takeshita, Kota Nishihama, Valeria Fridman, Taro Yasuma, Corina Gabazza, Masaaki Toda, Yutaka Yano, Esteban Gabazza
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08564
[Presentation] トロンボモジュリンのストレプトゾトシン誘発糖尿病に対する効果の検討2021
- Author(s)
  岡野優子，内田明宏，竹下敦郎，西濱康太，安間太郎，ガバザコリーナ，戸田雅昭，矢野裕，ガバザエステバン
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-21K16185
[Presentation] Amelioration of kidney fibrosis and dysfunction by recombinant thrombomodulin2021
- Author(s)
  Asturo Takeshita, Taro Yasuma, Yuko Okano, Kota Nishihama, Valeria Fridman D'Alessandro, Masaaki Toda, Corina N. D'Alessandro-Gabazza, Yutaka Yano, Esteban C. Gabazza
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08564

1. Gabazza Esteban (00293770)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
2. 戸田雅昭 (10202201)

# of Collaborated Projects: 4 results

# of Collaborated Products: 6 results
3. 安間太郎 (80773887)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. GABAZZA CORINA (10750656)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 小林哲 (20437114)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. 藤本源 (90378399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 矢野裕 (10263021)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 岡野優子 (40964565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 都丸敦史

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 野阪哲哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takeshita Atsuro 竹下 敦郎

Research Projects

Research Products

Co-Researchers

COPD急性増悪への革新的アプローチ：細菌叢由来細胞死誘導因子阻害剤の効果

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of chronic inflammation induced by dysbiosis in type 2 diabetes mellitus

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細菌叢由来ペプチドのNASH肝線維化における意義解明と臨床応用への展開

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

トロンボモジュリンによる膵β細胞保護作用の分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new treatment for COVID-19-related acute lung injury targeting the microbiota-derived peptide corisin

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Suppression of progressive diabetic nephropathy stages by thrombomodulinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigating the role of mucin in pulmonary fibrosis-associated microbiota dysbiosis using MUC5B overexpressing mice

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Role of microbiota-derived corisin in coagulation activation during SARS-CoV-2 infection.2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of a Microbiota-Derived Peptide Ameliorates Established Acute Lung Injury2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transforming Growth Factorβ1 Overexpression Is Associated with Insulin Resistance and Rapidly Progressive Kidney Fibrosis under Diabetic Conditions.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of lung microbiota-derived proapoptotic peptides ameliorates acute exacerbation of pulmonary fibrosis.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protective Role of Recombinant Human Thrombomodulin in Diabetes Mellitus.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Microbiome-Derived Peptide Induces Apoptosis of Cells from Different Tissues2021

Author(s)

Journal Title

DOI

Takeshita Atsuro 竹下敦郎

[Presentation] 細菌由来ペプチドcorisinがポドサイト，尿細管上皮および血管内皮細胞の細胞死を誘導する2023

[Presentation] TGFβ1過剰発現マウスは糖尿病誘発により腎線維化が急速に進行する2023

[Presentation] TGFβ1過剰発現糖尿病マウスにおけるインスリン抵抗性の検討2023

[Presentation] トロンボモジュリンのストレプトゾトシン誘発糖尿病に対する効果の検討2021