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Sakamoto Hirokazu  坂本 寛和

Researcher Number 10837397
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-9881-5173
Affiliation (Current) 2025: 東京大学, 大学院医学系研究科(医学部), 助教
Affiliation (based on the past Project Information) *help 2021 – 2025: 東京大学, 大学院医学系研究科(医学部), 助教
2019 – 2020: 東京大学, 大学院医学系研究科(医学部), 特任研究員
Review Section/Research Field
Principal Investigator
Basic Section 46010:Neuroscience-general-related / Transformative Research Areas, Section (III) / Basic Section 46030:Function of nervous system-related
Except Principal Investigator
Medium-sized Section 46:Neuroscience and related fields
Keywords
Principal Investigator
シナプス / 記憶符号化 / 空間記憶 / 超解像イメージング / 超解像顕微鏡 / 海馬 / 学習 / 記憶 / シナプス可塑性 / プレシナプス
Except Principal Investigator
シナプス / 可塑性 / 神経
  • Research Projects

    (6 results)
  • Research Products

    (14 results)
  • Co-Researchers

    (4 People)
  •  ナノ空間シナプスプロテオミクスによる記憶形成メカニズムの解明Principal Investigator

    • Principal Investigator
      坂本 寛和
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 46030:Function of nervous system-related
    • Research Institution
      The University of Tokyo
  •  神経伝達物質の放出を制御するバイオロジカルクラスターの動作原理Principal Investigator

    • Principal Investigator
      坂本 寛和
    • Project Period (FY)
      2025 – 2026
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      The University of Tokyo
  •  Undesrtanding and manipulation of the cortical synapse population

    • Principal Investigator
      坂場 武史
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 46:Neuroscience and related fields
    • Research Institution
      Doshisha University
  •  Presynaptic molecular correlates of memory encodingPrincipal Investigator

    • Principal Investigator
      Sakamoto Hirokazu
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 46010:Neuroscience-general-related
    • Research Institution
      The University of Tokyo
  •  Nanoscale visualization and mechanstic understanding of presynaptic plasticity

    • Principal Investigator
      坂場 武史
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 46:Neuroscience and related fields
    • Research Institution
      Doshisha University
  •  Nanoscale distribution of Munc13-1 and calcium channels at the presynaptic terminalsPrincipal Investigator

    • Principal Investigator
      Sakamoto Hirokazu
    • Project Period (FY)
      2019 – 2020
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 46010:Neuroscience-general-related
    • Research Institution
      The University of Tokyo

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

  • [Journal Article] RIM-BP2 regulates Ca2+ channel abundance and neurotransmitter release at hippocampal mossy fiber terminals2024

    • Author(s)
      Miyano Rinako、Sakamoto Hirokazu、Hirose Kenzo、Sakaba Takeshi
    • Journal Title

      eLife

      Volume: 12

    • DOI

      10.7554/elife.90799

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20KK0171, KAKENHI-PROJECT-21H02598
  • [Journal Article] Increased vesicle fusion competence underlies long-term potentiation at hippocampal mossy fiber synapses2023

    • Author(s)
      Fukaya Ryota、Hirai Himawari、Sakamoto Hirokazu、Hashimotodani Yuki、Hirose Kenzo、Sakaba Takeshi
    • Journal Title

      Science Advances

      Volume: 9 Issue: 8 Pages: 1-13

    • DOI

      10.1126/sciadv.add3616

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20KK0171, KAKENHI-PUBLICLY-21H05701, KAKENHI-PROJECT-20H03358, KAKENHI-PROJECT-20H03427, KAKENHI-PROJECT-21H02598, KAKENHI-PROJECT-21K19316, KAKENHI-PROJECT-21K15183
  • [Journal Article] Synapse type-specific molecular nanoconfigurations of the presynaptic active zone in the hippocampus identified by systematic nanoscopy2022

    • Author(s)
      Sakamoto Hirokazu、Kimpara Naoya、Namiki Shigeyuki、Hamada Shun、Ohtsuka Toshihisa、Hirose Kenzo
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2022.03.11.483942

    • Open Access
    • Data Source
      KAKENHI-PROJECT-21K15183
  • [Journal Article] RIM-BP2 is required for rapid neurotransmitter release through regulation of Ca<sup>2+</sup> channel clustering at hippocampal mossy fiber terminals2022

    • Author(s)
      Miyano Rinako、Sakamoto Hirokazu、Hirose Kenzo、Sakaba Takeshi
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2022.08.29.505728

    • Open Access
    • Data Source
      KAKENHI-PROJECT-21K15183
  • [Journal Article] Real-time in vivo imaging of extracellular ATP in the brain with a hybrid-type fluorescent sensor2020

    • Author(s)
      Kitajima N, Takikawa K, Sekiya H, Satoh K, Asanuma D, Sakamoto H, Takahashi S, Hanaoka K, Urano Y, Namiki S, Iino M, Hirose K
    • Journal Title

      eLife

      Volume: 9 Pages: 1-18

    • DOI

      10.7554/elife.57544

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07286, KAKENHI-PROJECT-18K14915, KAKENHI-PROJECT-20K22699, KAKENHI-PROJECT-16H05099, KAKENHI-PROJECT-20H03427, KAKENHI-PROJECT-20H03430, KAKENHI-PROJECT-19K22247, KAKENHI-PROJECT-19K16251
  • [Journal Article] Nanoscale Molecular Imaging of Presynaptic Active Zone Proteins in Cultured Hippocampal Neurons2020

    • Author(s)
      Sakamoto Hirokazu、Namiki Shigeyuki、Hirose Kenzo
    • Journal Title

      Neuromethods

      Volume: 154 Pages: 245-259

    • DOI

      10.1007/978-1-0716-0532-5_12

    • ISBN
      9781071605318, 9781071605325
    • Data Source
      KAKENHI-PROJECT-19K16251
  • [Presentation] Interactions of active zone proteins with Munc13-1 that contribute to the formation of synaptic vesicle release sites2022

    • Author(s)
      小島 佑介、坂本 寛和、並木 繁行、廣瀬 謙造
    • Organizer
      第95回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-21K15183
  • [Presentation] 超解像顕微鏡システムによる シナプス分子の系統的可視化解析2022

    • Author(s)
      坂本 寛和、大西 泰地、廣瀬 謙造
    • Organizer
      第96回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-21K15183
  • [Presentation] 恐怖記憶形成に関与するシナプスの検出法の開発2022

    • Author(s)
      大西 泰地、坂本 寛和、大久保 洋平、並木 繁行、廣瀬 謙造
    • Organizer
      第96回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-21K15183
  • [Presentation] Development of a method to identify synapses associated with memory formation2022

    • Author(s)
      大西 泰地、坂本 寛和、大久保 洋平、廣瀬 謙造
    • Organizer
      第95回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-21K15183
  • [Presentation] シナプス小胞放出サイトの形成に寄与するMunc13-1とRIMの相互作用2022

    • Author(s)
      小島 佑介、坂本 寛和、並木 繁行、廣瀬 謙造
    • Organizer
      第96回 日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-21K15183
  • [Presentation] Interactions of active zone proteins with Munc13-1 that contribute to the formation of synaptic vesicle release sites2021

    • Author(s)
      小島 佑介、坂本 寛和、並木 繁行、廣瀬 謙造
    • Organizer
      日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-21K15183
  • [Presentation] Development of a method to identify synapses associated with memory formation2021

    • Author(s)
      大西 泰地、坂本 寛和、大久保 洋平、廣瀬 謙造
    • Organizer
      日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-21K15183
  • [Presentation] Micro- and nano-scale mapping of neurotransmitter release machineries in the hippocampus2019

    • Author(s)
      Hirokazu Sakamoto
    • Organizer
      FMP Symposium: Understanding Synapses from molecules to function
    • Data Source
      KAKENHI-PROJECT-19K16251
  • 1.  坂場 武史 (80609511)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 2.  三木 崇史 (10598577)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  正水 芳人 (90608530)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  NAMIKI Shigeyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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