Sakamoto Hirokazu 坂本寛和

Researcher Number	10837397
Other IDs	https://orcid.org/0000-0002-9881-5173
Affiliation (Current)	2025: 東京大学, 大学院医学系研究科(医学部), 助教
Affiliation (based on the past Project Information) *help	2021 – 2025: 東京大学, 大学院医学系研究科(医学部), 助教 2019 – 2020: 東京大学, 大学院医学系研究科(医学部), 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 46010:Neuroscience-general-related / Basic Section 46030:Function of nervous system-related / Transformative Research Areas, Section (III) Except Principal Investigator Medium-sized Section 46:Neuroscience and related fields / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator シナプス / 記憶符号化 / 超解像顕微鏡 / シナプスプロテオミクス / バイオロジカルクラスター / 自己組織化 / 超分子集合 / 空間記憶 / 超解像イメージング / 海馬 … More / 学習 / 記憶 / シナプス可塑性 / プレシナプス … More Except Principal Investigator シナプス / 加齢 / アセチルコリン / 神経筋接合部 / 可塑性 / 神経 Less

神経伝達物質の放出を制御するバイオロジカルクラスターの動作原理Principal Investigator
- Principal Investigator
  
  坂本寛和
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
ナノ空間シナプスプロテオミクスによる記憶形成メカニズムの解明Principal Investigator
- Principal Investigator
  
  坂本寛和
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 46030:Function of nervous system-related
- Research Institution
  The University of Tokyo
加齢依存的骨格筋機能低下の解明：構造・生理機能の統合的アプローチ
- Principal Investigator
  
  山澤徳志子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Jikei University School of Medicine
Undesrtanding and manipulation of the cortical synapse population
- Principal Investigator
  
  坂場武史
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 46:Neuroscience and related fields
- Research Institution
  Doshisha University
Presynaptic molecular correlates of memory encodingPrincipal Investigator
- Principal Investigator
  
  Sakamoto Hirokazu
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  The University of Tokyo
Nanoscale visualization and mechanstic understanding of presynaptic plasticity
- Principal Investigator
  
  坂場武史
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 46:Neuroscience and related fields
- Research Institution
  Doshisha University
Nanoscale distribution of Munc13-1 and calcium channels at the presynaptic terminalsPrincipal Investigator
- Principal Investigator
  
  Sakamoto Hirokazu
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 46010:Neuroscience-general-related
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] RIM-BP2 regulates Ca2+ channel abundance and neurotransmitter release at hippocampal mossy fiber terminals2024
- Author(s)
  Miyano Rinako、Sakamoto Hirokazu、Hirose Kenzo、Sakaba Takeshi
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.90799
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20KK0171, KAKENHI-PROJECT-21H02598
[Journal Article] Increased vesicle fusion competence underlies long-term potentiation at hippocampal mossy fiber synapses2023
- Author(s)
  Fukaya Ryota、Hirai Himawari、Sakamoto Hirokazu、Hashimotodani Yuki、Hirose Kenzo、Sakaba Takeshi
- Journal Title
  
  Science Advances
  
  Volume: 9 Issue: 8 Pages: 1-13
- DOI
  10.1126/sciadv.add3616
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0171, KAKENHI-PUBLICLY-21H05701, KAKENHI-PROJECT-20H03358, KAKENHI-PROJECT-20H03427, KAKENHI-PROJECT-21H02598, KAKENHI-PROJECT-21K19316, KAKENHI-PROJECT-21K15183
[Journal Article] Synapse type-specific molecular nanoconfigurations of the presynaptic active zone in the hippocampus identified by systematic nanoscopy2022
- Author(s)
  Sakamoto Hirokazu、Kimpara Naoya、Namiki Shigeyuki、Hamada Shun、Ohtsuka Toshihisa、Hirose Kenzo
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2022.03.11.483942
- Open Access
- Data Source
  KAKENHI-PROJECT-21K15183
[Journal Article] RIM-BP2 is required for rapid neurotransmitter release through regulation of Ca<sup>2+</sup> channel clustering at hippocampal mossy fiber terminals2022
- Author(s)
  Miyano Rinako、Sakamoto Hirokazu、Hirose Kenzo、Sakaba Takeshi
- Journal Title
  
  bioRxiv
  
  Volume: -
- DOI
  10.1101/2022.08.29.505728
- Open Access
- Data Source
  KAKENHI-PROJECT-21K15183
[Journal Article] Real-time in vivo imaging of extracellular ATP in the brain with a hybrid-type fluorescent sensor2020
- Author(s)
  Kitajima N, Takikawa K, Sekiya H, Satoh K, Asanuma D, Sakamoto H, Takahashi S, Hanaoka K, Urano Y, Namiki S, Iino M, Hirose K
- Journal Title
  
  eLife
  
  Volume: 9 Pages: 1-18
- DOI
  10.7554/elife.57544
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07286, KAKENHI-PROJECT-18K14915, KAKENHI-PROJECT-20K22699, KAKENHI-PROJECT-16H05099, KAKENHI-PROJECT-20H03427, KAKENHI-PROJECT-20H03430, KAKENHI-PROJECT-19K22247, KAKENHI-PROJECT-19K16251
[Journal Article] Nanoscale Molecular Imaging of Presynaptic Active Zone Proteins in Cultured Hippocampal Neurons2020
- Author(s)
  Sakamoto Hirokazu、Namiki Shigeyuki、Hirose Kenzo
- Journal Title
  
  Neuromethods
  
  Volume: 154 Pages: 245-259
- DOI
  10.1007/978-1-0716-0532-5_12
- ISBN
  9781071605318, 9781071605325
- Data Source
  KAKENHI-PROJECT-19K16251
[Presentation] Interactions of active zone proteins with Munc13-1 that contribute to the formation of synaptic vesicle release sites2022
- Author(s)
  小島佑介、坂本寛和、並木繁行、廣瀬謙造
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K15183
[Presentation] 超解像顕微鏡システムによるシナプス分子の系統的可視化解析2022
- Author(s)
  坂本寛和、大西泰地、廣瀬謙造
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K15183
[Presentation] 恐怖記憶形成に関与するシナプスの検出法の開発2022
- Author(s)
  大西泰地、坂本寛和、大久保洋平、並木繁行、廣瀬謙造
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K15183
[Presentation] Development of a method to identify synapses associated with memory formation2022
- Author(s)
  大西泰地、坂本寛和、大久保洋平、廣瀬謙造
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K15183
[Presentation] シナプス小胞放出サイトの形成に寄与するMunc13-1とRIMの相互作用2022
- Author(s)
  小島佑介、坂本寛和、並木繁行、廣瀬謙造
- Organizer
  第96回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K15183
[Presentation] Interactions of active zone proteins with Munc13-1 that contribute to the formation of synaptic vesicle release sites2021
- Author(s)
  小島佑介、坂本寛和、並木繁行、廣瀬謙造
- Organizer
  日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K15183
[Presentation] Development of a method to identify synapses associated with memory formation2021
- Author(s)
  大西泰地、坂本寛和、大久保洋平、廣瀬謙造
- Organizer
  日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-21K15183
[Presentation] Micro- and nano-scale mapping of neurotransmitter release machineries in the hippocampus2019
- Author(s)
  Hirokazu Sakamoto
- Organizer
  FMP Symposium: Understanding Synapses from molecules to function
- Data Source
  KAKENHI-PROJECT-19K16251

1. 坂場武史 (80609511)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. 三木崇史 (10598577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 正水芳人 (90608530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 山澤徳志子 (00282616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 谷端淳 (00508426)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 鈴木江津子 (60424313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 金丸和典 (10456105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAMIKI Shigeyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakamoto Hirokazu 坂本 寛和

Research Projects

Research Products

Co-Researchers

神経伝達物質の放出を制御するバイオロジカルクラスターの動作原理Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ナノ空間シナプスプロテオミクスによる記憶形成メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

加齢依存的骨格筋機能低下の解明：構造・生理機能の統合的アプローチ

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Undesrtanding and manipulation of the cortical synapse population

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Presynaptic molecular correlates of memory encodingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Nanoscale visualization and mechanstic understanding of presynaptic plasticity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Nanoscale distribution of Munc13-1 and calcium channels at the presynaptic terminalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] RIM-BP2 regulates Ca2+ channel abundance and neurotransmitter release at hippocampal mossy fiber terminals2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased vesicle fusion competence underlies long-term potentiation at hippocampal mossy fiber synapses2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synapse type-specific molecular nanoconfigurations of the presynaptic active zone in the hippocampus identified by systematic nanoscopy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RIM-BP2 is required for rapid neurotransmitter release through regulation of Ca<sup>2+</sup> channel clustering at hippocampal mossy fiber terminals2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Real-time in vivo imaging of extracellular ATP in the brain with a hybrid-type fluorescent sensor2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nanoscale Molecular Imaging of Presynaptic Active Zone Proteins in Cultured Hippocampal Neurons2020

Author(s)

Journal Title

DOI

ISBN

Data Source

[Presentation] Interactions of active zone proteins with Munc13-1 that contribute to the formation of synaptic vesicle release sites2022

Author(s)

Organizer

Sakamoto Hirokazu 坂本寛和

[Presentation] 超解像顕微鏡システムによるシナプス分子の系統的可視化解析2022