Negoro Ryosuke 根来亮介

Researcher Number	10844045
Other IDs	https://orcid.org/0000-0002-6567-575X
Affiliation (Current)	2025: 立命館大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2025: 立命館大学, 薬学部, 助教 2021 – 2023: 立命館大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator 薬物代謝 / 薬物吸収 / Caco-2 細胞 / 消化管代謝 / UGT1A1 / CYP3A4 / Caco-2 cell / CRISPR-Cas9 / ゲノム編集

Research Projects
(2 results)
Research Products
(11 results)

薬物吸収・代謝の精密評価を目指した絨毛構造を有する腸管上皮細胞モデルの開発Principal Investigator
- Principal Investigator
  
  根来亮介
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Ritsumeikan University
Generation of predictive intestinal models of drug absorption, metabolism and toxicity using genome-editing technology.Principal Investigator
- Principal Investigator
  
  Negoro Ryosuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Ritsumeikan University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Generation of Caco-2?cells with predictable metabolism by CYP3A4, UGT1A1 and CES using the PITCh system2023
- Author(s)
  Yamada Naoki、Negoro Ryosuke、Watanabe Keita、Fujita Takuya
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 50 Pages: 100497-100497
- DOI
  10.1016/j.dmpk.2023.100497
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15264, KAKENHI-PROJECT-20K07190
[Journal Article] 5-ALA treatment increases intracellular heme levels and enhances CYP3A4 activity in genome-edited Caco-2 cells2023
- Author(s)
  Watanabe Keita、Negoro Ryosuke、Fujita Takuya
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 664 Pages: 94-99
- DOI
  10.1016/j.bbrc.2023.04.077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15264
[Journal Article] Generation of Caco-2 cells stably expressing CYP3A4・POR・UGT1A1 and?CYP3A4・POR・UGT1A1*6?using a PITCh system2021
- Author(s)
  Negoro Ryosuke、Yamada Naoki、Watanabe Keita、Kono Yusuke、Fujita Takuya
- Journal Title
  
  Archives of Toxicology
  
  Volume: 96 Issue: 2 Pages: 499-510
- DOI
  10.1007/s00204-021-03175-0
- Data Source
  KAKENHI-PROJECT-21K15264
[Presentation] ゲノム編集技術を用いた高機能な腸管上皮細胞・肝細胞の作製と腸-肝チップの開発2024
- Author(s)
  根来亮介
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-21K15264
[Presentation] Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1 and CES using genome-editing technology.2023
- Author(s)
  Ryosuke Negoro, Takuya Fujita
- Organizer
  2023 ICCP450/JSSX
- Data Source
  KAKENHI-PROJECT-21K15264
[Presentation] ゲノム編集技術を用いた創薬研究に応用可能な腸管上皮細胞モデルの作製―CYP3A4、UGT1A1、CES 代謝を評価可能なCaco-2細胞―2023
- Author(s)
  根来亮介、藤田卓也
- Organizer
  第73回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K15264
[Presentation] Generation of highly functional intestinal epithelial cell and hepatocyte models applicable to pharmacokinetic studies using genome editing technology2023
- Author(s)
  Ryosuke Negoro
- Organizer
  The Academy of Pharmaceutical Science and Technology, Japan Global Education Seminar 2023-1st
- Invited
- Data Source
  KAKENHI-PROJECT-21K15264
[Presentation] PITChシステムを用いた安価に繰り返し薬物代謝実験が可能な腸・肝細胞モデルの開発2023
- Author(s)
  根来亮介、出口清香、高山和雄、藤田卓也
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K15264
[Presentation] PITChシステムを用いて複数の薬物代謝酵素を安定発現した腸・肝細胞モデルの開発2022
- Author(s)
  根来亮介、出口清香、高山和雄、藤田卓也
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-21K15264
[Presentation] ゲノム編集技術を用いて複数の薬物代謝酵素を安定発現した腸・肝細胞モデルの開発2022
- Author(s)
  根来亮介、出口清香、高山和雄、藤田卓也
- Organizer
  日本組織培養学会第94回大会
- Data Source
  KAKENHI-PROJECT-21K15264
[Presentation] ゲノム編集技術を用いた CYP3A4 および加水分解酵素による代謝を予測可能なCaco-2 細胞の作製2021
- Author(s)
  山田尚生、根来亮介、藤田卓也
- Organizer
  第71回日本薬学会関西支部総会・大会
- Data Source
  KAKENHI-PROJECT-21K15264

Negoro Ryosuke 根来 亮介

Research Projects

Research Products

薬物吸収・代謝の精密評価を目指した絨毛構造を有する腸管上皮細胞モデルの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Generation of predictive intestinal models of drug absorption, metabolism and toxicity using genome-editing technology.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Generation of Caco-2?cells with predictable metabolism by CYP3A4, UGT1A1 and CES using the PITCh system2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 5-ALA treatment increases intracellular heme levels and enhances CYP3A4 activity in genome-edited Caco-2 cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of Caco-2 cells stably expressing CYP3A4・POR・UGT1A1 and?CYP3A4・POR・UGT1A1*6?using a PITCh system2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] ゲノム編集技術を用いた高機能な腸管上皮細胞・肝細胞の作製と腸-肝チップの開発2024

Author(s)

Organizer

Data Source

[Presentation] Generation of Caco-2 cells with predictable metabolism by CYP3A4, UGT1A1 and CES using genome-editing technology.2023

Author(s)

Organizer

Data Source

[Presentation] ゲノム編集技術を用いた創薬研究に応用可能な腸管上皮細胞モデルの作製―CYP3A4、UGT1A1、CES 代謝を評価可能なCaco-2細胞―2023

Author(s)

Organizer

Data Source

[Presentation] Generation of highly functional intestinal epithelial cell and hepatocyte models applicable to pharmacokinetic studies using genome editing technology2023

Author(s)

Organizer

Data Source

[Presentation] PITChシステムを用いた安価に繰り返し薬物代謝実験が可能な腸・肝細胞モデルの開発2023

Author(s)

Organizer

Data Source

[Presentation] PITChシステムを用いて複数の薬物代謝酵素を安定発現した腸・肝細胞モデルの開発2022

Author(s)

Organizer

Data Source

[Presentation] ゲノム編集技術を用いて複数の薬物代謝酵素を安定発現した腸・肝細胞モデルの開発2022

Author(s)

Organizer

Data Source

[Presentation] ゲノム編集技術を用いた CYP3A4 および加水分解酵素による代謝を予測可能なCaco-2 細胞 の作製2021

Author(s)

Organizer

Data Source

Negoro Ryosuke 根来亮介

[Presentation] ゲノム編集技術を用いた CYP3A4 および加水分解酵素による代謝を予測可能なCaco-2 細胞の作製2021