Koide Shuhei 小出周平

Researcher Number	10845126
Other IDs	https://orcid.org/0000-0001-8599-6115
Affiliation (Current)	2025: 東京大学, 医科学研究所, 特任助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 東京大学, 医科学研究所, 特任助教 2020 – 2021: 東京大学, 医科学研究所, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 加齢 / シングルセル解析 / 造血器腫瘍 / 老化 / 造血幹細胞 / 炎症 / 分子シャペロン / 老化マーカー / Clusterin

Deciphering Hematopoietic Stem Cell Aging via the New Marker Clusterin and Establishing Control StrategiesPrincipal Investigator
- Principal Investigator
  
  小出周平
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Elucidation of the principles of hematopoietic stem cells in aging and overcoming aging-related diseasesPrincipal Investigator
- Principal Investigator
  
  Koide Shuhei
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Elucidation of the Mechanism of Functional Decline of Aged Hematopoietic Stem Cells and Attempts to Restore Their Function.Principal Investigator
- Principal Investigator
  
  Koide Shuhei
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Histone H3.3 variant plays a critical role on zygote-to-oocyst development in malaria parasites2024
- Author(s)
  2.Tateishi YS, Araki T, Kawai S, Koide S, Umeki Y, Imai T, Saito-Nakano Y, Kikuchi M, Iwama A, Hisaeda H, Coban C, Annoura T
- Journal Title
  
  Parasitology International
  
  Volume: 100 Pages: 102856-102856
- DOI
  10.1016/j.parint.2024.102856
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07530, KAKENHI-PROJECT-22K16298
[Journal Article] Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis2024
- Author(s)
  Watanuki S et al
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.87674
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18137, KAKENHI-PROJECT-23K06416, KAKENHI-PROJECT-21K06072, KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-23K23797
[Journal Article] Mesenchymal loss of p53 alters stem cell capacity and models human soft tissue sarcoma traits.2023
- Author(s)
  Sorimachi Y, Kobayashi H, Shiozawa Y, Koide S, Nakato R, Shimizu Y, Okamura T, Shirahige K, Iwama A, Goda N, Takubo K, Takubo K.
- Journal Title
  
  Stem Cell Reports
  
  Volume: S2213-6711(23) Issue: 5 Pages: 00097-8
- DOI
  10.1016/j.stemcr.2023.03.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05940, KAKENHI-PROJECT-23K06416, KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-22KJ2948, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H05686, KAKENHI-PROJECT-21H02957
[Journal Article] UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease2023
- Author(s)
  Rizq Ola、Mimura Naoya、Oshima Motohiko、Momose Shuji、Takayama Naoya、Itokawa Naoki、Koide Shuhei、Shibamiya Asuka、Miyamoto-Nagai Yurie、Rizk Mohamed、Nakajima-Takagi Yaeko、Aoyama Kazumasa、Wang Changshan、Saraya Atsunori、Ito Ryoji、Seimiya Masanori、et al
- Journal Title
  
  Leukemia
  
  Volume: 37 Issue: 9 Pages: 1895-1907
- DOI
  10.1038/s41375-023-01928-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07858, KAKENHI-PROJECT-22K08495, KAKENHI-PROJECT-23K05608, KAKENHI-PROJECT-23K06449, KAKENHI-PROJECT-23K07851, KAKENHI-PROJECT-20K07396, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-22K16318, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-23K27442
[Journal Article] The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms2023
- Author(s)
  1.Shibamiya A, Miyamoto-Nagai Y, Koide S, Oshima M, Rizq O, Aoyama K, Nakajima-Takagi Y, Kato R, Kayamori K, Isshiki Y, Oshima-Hasegawa N, Muto T, Tsukamoto S, Takeda Y, Koyama-Nasu R, Chiba T, Honda H, Yokote K, Iwama A, Sakaida E, Mimura N.
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: － Issue: 8 Pages: 2635-2648
- DOI
  10.1007/s00262-023-03447-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19497, KAKENHI-PROJECT-22K08495, KAKENHI-PROJECT-23K07851, KAKENHI-PROJECT-22K16298, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-23K27442
[Journal Article] Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis2023
- Author(s)
  Nakajima-Takagi Yaeko、Oshima Motohiko、Takano Junichiro、Koide Shuhei、Itokawa Naoki、Uemura Shun、Yamashita Masayuki、Andoh Shohei、Aoyama Kazumasa、Isshiki Yusuke、Shinoda Daisuke、Saraya Atsunori、Arai Fumio、Yamaguchi Kiyoshi、Furukawa Yoichi、Koseki Haruhiko、Ikawa Tomokatsu、Iwama Atsushi
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.83004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07806, KAKENHI-PROJECT-23K07851, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K16298, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653
[Journal Article] A culture platform to study quiescent hematopoietic stem cells following genome editing2022
- Author(s)
  Shiroshita Kohei、Kobayashi Hiroshi、Watanuki Shintaro、Karigane Daiki、Sorimachi Yuriko、Fujita Shinya、Tamaki Shinpei、Haraguchi Miho、Itokawa Naoki、Aoyama Kazumasa、Koide Shuhei、Masamoto Yosuke、Kobayashi Kenta、Nakamura-Ishizu Ayako、Kurokawa Mineo、Iwama Atsushi、Okamoto Shinichiro、Kataoka Keisuke、Takubo Keiyo
- Journal Title
  
  Cell Reports Methods
  
  Volume: 2 Issue: 12 Pages: 100354-100354
- DOI
  10.1016/j.crmeth.2022.100354
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-21J11016, KAKENHI-PROJECT-22KJ2948, KAKENHI-PROJECT-23K24366
[Journal Article] Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation2022
- Author(s)
  Jimbo K, Nakajima-Takagi Y, Ito T, Koide S, Nannya Y, Iwama A, Tojo A, Konuma T
- Journal Title
  
  Leukemia
  
  Volume: In press Issue: 6 Pages: 1550-1562
- DOI
  10.1038/s41375-022-01564-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08748, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-22K16317
[Journal Article] CD244 expression represents functional decline of murine hematopoietic stem cells after in vitro culture2022
- Author(s)
  Koide Shuhei、Sigurdsson Valgardur、Radulovic Visnja、Saito Kiyoka、Zheng Zhiqian、Lang Stefan、Soneji Shamit、Iwama Atsushi、Miharada Kenichi
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 1 Pages: 103603-103603
- DOI
  10.1016/j.isci.2021.103603
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17370
[Journal Article] Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells2022
- Author(s)
  Itokawa Naoki、Oshima Motohiko、Koide Shuhei、Takayama Naoya、Kuribayashi Wakako、Nakajima-Takagi Yaeko、Aoyama Kazumasa、Yamazaki Satoshi、Yamaguchi Kiyoshi、Furukawa Yoichi、Eto Koji、Iwama Atsushi
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 2691-2691
- DOI
  10.1038/s41467-022-30440-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-21F21108, KAKENHI-PROJECT-20K07563, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-21H05047
[Journal Article] Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia2022
- Author(s)
  Jimbo Koji、Hattori Ayuna、Koide Shuhei、Ito Takahiro、Sasaki Katsuhiro、Iwai Kazuhiro、Nannya Yasuhito、Iwama Atsushi、Tojo Arinobu、Konuma Takaaki
- Journal Title
  
  Leukemia
  
  Volume: 37 Issue: 1 Pages: 122-133
- DOI
  10.1038/s41375-022-01750-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-22K16317, KAKENHI-PROJECT-22H04988, KAKENHI-PROJECT-20K07337, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-20K08748
[Journal Article] Noncanonical EZH2 drives retinoic acid resistance of variant acute promyelocytic leukemias2022
- Author(s)
  Poplineau Mathilde、Platet Nadine、Mazuel Adrien、Herault Leonard、N’Guyen Lia、Koide Shuhei、Nakajima-Takagi Yaeko、Kuribayashi Wakako、Carbuccia Nadine、Haboub Loreen、Vernerey Julien、Oshima Motohiko、Birnbaum Daniel、Iwama Atsushi、Duprez Estelle
- Journal Title
  
  Blood
  
  Volume: 140 Issue: 22 Pages: 2358-2370
- DOI
  10.1182/blood.2022015668
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16298
[Journal Article] CD271 + CD51 + PALLADIN - Human Mesenchymal Stromal Cells Possess Enhanced Ossicle-Forming Potential2021
- Author(s)
  Sezaki Maiko、Biswas Subinoy、Nakata Sayuri、Oshima Motohiko、Koide Shuhei、Ho Nicole Pui Yu、Okamoto Nobukazu、Miyamoto Takeshi、Iwama Atsushi、Takizawa Hitoshi
- Journal Title
  
  Stem Cells and Development
  
  Volume: 30 Issue: 14 Pages: 725-735
- DOI
  10.1089/scd.2021.0021
- Data Source
  KAKENHI-PROJECT-20K17370
[Journal Article] Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche2021
- Author(s)
  Kuribayashi W, Oshima M, Itokawa N, Koide S, Nakajima-Takagi Y, Yamashita M, Yamazaki S, Rahmutulla B, Miura F, Ito T, Kaneda A, Iwama A.
- Journal Title
  
  J Exp Med
  
  Volume: 218 Issue: 3
- DOI
  10.1084/jem.20192283
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21612, KAKENHI-PROJECT-19KK0216, KAKENHI-PLANNED-19H05746, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-20K17370, KAKENHI-PROJECT-21K08366
[Journal Article] Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis2021
- Author(s)
  Shinoda Daisuke、Nakajima-Takagi Yaeko、Oshima Motohiko、Koide Shuhei、Aoyama Kazumasa、Saraya Atsunori、Harada Hironori、Rahmutulla Bahityar、Kaneda Atsushi、Yamaguchi Kiyoshi、Furukawa Yoichi、Koseki Haruhiko、Shimoda Kazuya、Tanaka Tomoaki、Sashida Goro、Iwama Atsushi
- Journal Title
  
  Leukemia
  
  Volume: 36 Issue: 2 Pages: 452-463
- DOI
  10.1038/s41375-021-01402-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-20K21625, KAKENHI-PROJECT-20K17370, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-19H03708, KAKENHI-PROJECT-20H03713, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-21K19398, KAKENHI-PROJECT-19H04355, KAKENHI-PROJECT-20K07563
[Journal Article] PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome2020
- Author(s)
  Aoyama K, Shinoda D, Suzuki E, Nakajima-Takagi Y, Oshima M, Koide S, Rizq O, Si S, Tara S, Sashida G, Iwama A.
- Journal Title
  
  Leukemia
  
  Volume: 4 Issue: 4 Pages: 1156-1165
- DOI
  10.1038/s41375-020-01023-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17370, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-21K08366
[Presentation] Hematopoietic aging is regulated by the balance between two distinct hematopoietic stem cell populations2023
- Author(s)
  Shuhei Koide, Motohiko Oshima, Akira Nishiyama, Koichi Murakami, Yuta Yamada, Zhiqian Zheng, Yaeko Nakajima-Takagi, Tomohiko Tamura, Atsushi Iwama
- Organizer
  ISEH2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16298
[Presentation] Two distinctive hematopoietic stem cell populations coordinate hematopoietic aging2023
- Author(s)
  Shuhei Koide, Motohiko Oshima, Akira Nishiyama, Koichi Murakami, Naoki Itokawa, Yuta Yamada, Yaeko Nakajima-Takagi, Zhiqian Zheng, Tomohiko Tamura, Atsushi Iwama
- Organizer
  第20回幹細胞シンポジウム
- Data Source
  KAKENHI-PROJECT-22K16298
[Presentation] Dysfunctional Clusterin-Positive Hematopoietic Stem Cells Expand with Aging2022
- Author(s)
  Shuhei Koide, Motohiko Oshima, Akira Nishiyama, Koichi Murakami, Naoki Itokawa, Yaeko Nakajima-Takagi, Zhiqian Zheng, Nozomi Yusa, Kazuaki Yokoyama, Arinobu Tojo, Tomohiko Tamura, Atsushi Iwama
- Organizer
  64th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16298
[Presentation] Single-cell analysis reveals that Clusterin-positive hematopoietic stem cells with impaired stemness expand with aging2022
- Author(s)
  Shuhei Koide, Motohiko Oshima, Akira Nishiyama, Koichi Murakami, Zhiqian Zheng, Naoki Itokawa, Nakajima Yaeko, Nozomi Yusa, Kazuaki Yokoyama, Arinobu Tojo, Tomohiko Tamura, Atsushi Iwama
- Organizer
  ISEH 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16298
[Presentation] Clu-positive hematopoietic stem cells show decreased stemness and expand the number with aging2022
- Author(s)
  Shuhei Koide
- Organizer
  Hemato-Retreat 2022
- Invited
- Data Source
  KAKENHI-PROJECT-22K16298
[Presentation] Clu-positive hematopoietic stem cells show decreased stemness and expand with aging2022
- Author(s)
  小出周平、大島基彦、西山晃、村上紘一、テイシセン、中島やえ子、遊佐希、横山和明、東條有伸、田村智彦、岩間厚志
- Organizer
  第84回日本血液学会
- Data Source
  KAKENHI-PROJECT-22K16298
[Presentation] Unraveling heterogeneity of aged hematopoietic stem cells by single-cell RNA sequence analysis2021
- Author(s)
  Shuhei Koide
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17370

1. OHSHIMA Motohiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. SEIMIYA Masanori

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# of Collaborated Products: 1 results
3. HARADA Yuka

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4. 白髭克彦

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5. 小林央

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6. 小沼貴晶

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7. 久枝一

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8. 岩間厚志

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# of Collaborated Products: 1 results
9. 山崎聡

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10. 中島やえ子

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11. 原田浩徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koide Shuhei 小出 周平

Research Projects

Research Products

Co-Researchers

Deciphering Hematopoietic Stem Cell Aging via the New Marker Clusterin and Establishing Control StrategiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the principles of hematopoietic stem cells in aging and overcoming aging-related diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Mechanism of Functional Decline of Aged Hematopoietic Stem Cells and Attempts to Restore Their Function.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Histone H3.3 variant plays a critical role on zygote-to-oocyst development in malaria parasites2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mesenchymal loss of p53 alters stem cell capacity and models human soft tissue sarcoma traits.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] UTX inactivation in germinal center B cells promotes the development of multiple myeloma with extramedullary disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The pathogenetic significance of exhausted T cells in a mouse model of mature B cell neoplasms2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A culture platform to study quiescent hematopoietic stem cells following genome editing2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD244 expression represents functional decline of murine hematopoietic stem cells after in vitro culture2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Noncanonical EZH2 drives retinoic acid resistance of variant acute promyelocytic leukemias2022

Author(s)

Journal Title

Koide Shuhei 小出周平