Kikuchi Koichi 菊地晃一

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KIKUCHI Koichi 菊地晃一

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Researcher Number	10845259
Other IDs
Affiliation (Current)	2023: 東北大学, 大学病院, 非常勤講師
Affiliation (based on the past Project Information) *help	2023: 東北大学, 大学病院, 助教 2021: 東北大学, 大学病院, 助教 2020: 東北大学, 東北メディカル・メガバンク機構, 助教 2019: 東北大学, 東北メディカル・メガバンク機構, 非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / 0904:Internal medicine of the bio-information integration and related fields
Keywords	Principal Investigator 腸内細菌 / 腸腎連関 / フェニル硫酸 / 糖尿病性腎臓病 / 尿毒素 / 腸内細菌叢 / PS産生亢進 / 腸内細菌叢の変容 / TPL阻害剤 / バイオマーカー / 末期腎不全 / チロシンフェノールリアーゼ

糖尿病性腎臓病の新規バイオマーカーの確立と腸腎連関メカニズムの解明Principal Investigator
- Principal Investigator
  
  菊地晃一
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Tohoku University
糖尿病性腎臓病における腸腎連関の解明と新規DKDバイオマーカーの確立Principal Investigator
- Principal Investigator
  
  菊地晃一
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Tohoku University
The clinical application of a novel biomarker and therapeutic strategy in diabetic kidney diseasePrincipal Investigator
- Principal Investigator
  
  KIKUCHI Koichi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0904:Internal medicine of the bio-information integration and related fields
- Research Institution
  Tohoku University

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] (+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis.2022
- Author(s)
  16.Oikawa D, Yamashita S, Takahashi S, Waki T, Kikuchi K, Abe T, Katayama T, Nakayama T.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 590 Pages: 158-162
- DOI
  10.1016/j.bbrc.2021.12.088
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K16178
[Journal Article] SGLT‐1‐specific inhibition ameliorates renal failure and alters the gut microbial community in mice with adenine‐induced renal failure2021
- Author(s)
  Ho Hsin‐Jung、Kikuchi Koichi、Oikawa Daiki、Watanabe Shun、Kanemitsu Yoshitomi、Kagawa Yoshiteru、その他19名
- Journal Title
  
  Physiological Reports
  
  Volume: 9 Issue: 24 Pages: 15092-15092
- DOI
  10.14814/phy2.15092
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K11527, KAKENHI-PROJECT-21K08270, KAKENHI-PROJECT-21K16178, KAKENHI-PROJECT-20KK0363
[Journal Article] Fibromuscular dysplasia with recurrence after "long-term" following percutaneous transcatheter renal angioplasty: two case reports with a review of 26 patients2021
- Author(s)
  Oribe S, Toyohara T, Mishima E, Suzuki T, Kikuchi K, Watanabe S, Morita Y, Ota H, Seiji K, Miyazaki M, Takase K, Abe T
- Journal Title
  
  BMC Nephrol
  
  Volume: 22 Issue: 1 Pages: 187-187
- DOI
  10.1186/s12882-021-02342-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03613, KAKENHI-PROJECT-21K08245, KAKENHI-PROJECT-21K16178
[Journal Article] CE-MS-Based Identification of Uremic Solutes Specific to Hemodialysis Patients2021
- Author(s)
  Akiyama Yasutoshi、Kikuchi Koichi、Toyohara Takafumi、Mishima Eikan、Suzuki Chitose、Suzuki Takehiro、Nakayama Masaaki、Tomioka Yoshihisa、Soga Tomoyoshi、Abe Takaaki
- Journal Title
  
  Toxins
  
  Volume: 13 Issue: 5 Pages: 324-324
- DOI
  10.3390/toxins13050324
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08245, KAKENHI-PROJECT-21K08270, KAKENHI-PROJECT-21K16178
[Journal Article] Kidney enlargement effect of angioplasty for nonatherosclerotic renovascular disease: reversibility of ischemic kidney2020
- Author(s)
  Iwasaki Tomoyuki、Mishima Eikan、Suzuki Takehiro、Kikuchi Koichi、Toyohara Takafumi、Seiji Kazumasa、Takase Kei、Miyazaki Mariko、Harigae Hideo、Ito Sadayoshi、Abe Takaaki
- Journal Title
  
  Hypertension Research
  
  Volume: 43 Issue: 11 Pages: 1214-1221
- DOI
  10.1038/s41440-020-0473-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08198, KAKENHI-PROJECT-19K23933, KAKENHI-PROJECT-19K23994, KAKENHI-PROJECT-20H03613
[Journal Article] Germ-free conditions modulate host purine metabolism, exacerbating adenine-induced kidney damage.2020
- Author(s)
  Mishima E, Ishijo M, Kawabe T, Kikuchi K, Akiyama Y, Toyohara T, Suzuki C, Asao A, Ishii N, Fukuda S, Abe T
- Journal Title
  
  Toxins
  
  Volume: 12 Issue: 9 Pages: 547-547
- DOI
  10.3390/toxins12090547
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08766, KAKENHI-PROJECT-20K16272, KAKENHI-PROJECT-18K08198, KAKENHI-PROJECT-18K08199, KAKENHI-PROJECT-19K23933, KAKENHI-PROJECT-19K23994
[Journal Article] Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers2019
- Author(s)
  Mishima Eikan、Sato Emiko、Ito Junya、Yamada Ken-ichi、Suzuki Chitose、Oikawa Yoshitsugu、Matsuhashi Tetsuro、Kikuchi Koichi、Toyohara Takafumi、Suzuki Takehiro、Ito Sadayoshi、Nakagawa Kiyotaka、Abe Takaaki
- Journal Title
  
  Journal of the American Society of Nephrology
  
  Volume: 31 Issue: 2 Pages: 280-296
- DOI
  10.1681/asn.2019060570
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08198, KAKENHI-PROJECT-18K08199, KAKENHI-PROJECT-17H03977, KAKENHI-PROJECT-18K19405, KAKENHI-PROJECT-19K23994
[Journal Article] The guanylate cyclase C agonist linaclotide ameliorates the gut?cardio?renal axis in an adenine-induced mouse model of chronic kidney disease2019
- Author(s)
  Nanto-Hara F、Kanemitsu Y、Fukuda S、Kikuchi K、Asaji K、Saigusa D、Iwasaki T、Ho H、Mishima E、Suzuki T、Suzuki C、Tsukimi T、Matsuhashi T、Oikawa Y、Akiyama Y、Kure S、Owada Y、Tomioka Y、Soga T、Ito S, Abe T
- Journal Title
  
  Nephrology Dialysis Transplantation
  
  Volume: 35 Pages: 250-264
- DOI
  10.1093/ndt/gfz126
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08198, KAKENHI-PROJECT-18K08199, KAKENHI-PROJECT-19K09065, KAKENHI-PROJECT-17K00856, KAKENHI-PROJECT-18K19723, KAKENHI-PROJECT-19H04026, KAKENHI-PROJECT-19K23994
[Presentation] 12.Urinary phenyl sulfate predict the 2-year ACR deterioration in a DKD cohort.2022
- Author(s)
  Koichi Kikuchi, Ryota Kujirai, Yotaro Matsumoto, Koki Mise, Tomohiro Nakamura, Jun Wada, Yoshihisa Tomioka and Takaaki Abe
- Organizer
  The 11th Scientific Meeting of the Chronic Kidney Disease Frontier.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16178
[Presentation] he gut microbiome-derived phenyl sulfate is a novel predictive marker and cause of albuminuria in diabetic kidney disease.2021
- Author(s)
  Koichi Kikuchi, Takaaki Abe.
- Organizer
  American Society of Nephrology Kidney Week 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16178
[Presentation] 糖尿病性腎症の発症・進展予測マーカーとしてのフェニル硫酸の有用性2020
- Author(s)
  菊地晃一、三枝大輔、金光祥臣、松本洋太郎、三瀬広記、中村智洋、三島英換、豊原敬文、鈴木健弘、寳澤篤、和田淳、富岡佳久、阿部高明
- Organizer
  第63回日本腎臓学会総会
- Data Source
  KAKENHI-PROJECT-19K23994
[Presentation] Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease2020
- Author(s)
  Koichi Kikuchi, Daisuke Saigusa, Matsumoto Yotaro, Mise Koki, Tomohiro, Nakamura, Eikan Mishima, Takafumi Toyohara, Takehiro Suzuki, Atsushi Hozawa, Jun Wada, Yoshihisa Tomioka, Takaaki Abe
- Organizer
  第80回米国糖尿病学会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23994
[Presentation] The clinical importance of gut microbiome-derived phenyl sulfate as a predictive marker of albuminuria in diabetic kidney disease2020
- Author(s)
  菊地晃一
- Organizer
  9th CKD frontier meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23994
[Presentation] The clinical importance of gut microbiome-derived phenyl sulfate as a predictive marker of albuminuria in diabetic kidney disease2020
- Author(s)
  Koichi Kikuchi, Daisuke Saigusa, Yoshitomi Kanemitsu, Yotaro Matsumoto, Koki Mise, Tomohiro Nakamura, Atsushi Hozawa, Jun Wada, Yoshihisa Tomioka, Takaaki Abe
- Organizer
  9th CKD frontier meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23994
[Presentation] 糖尿病性腎臓病の新規発症、進展予測マーカーとしてのフェニル硫酸の意義2020
- Author(s)
  菊地晃一、三枝大輔、金光祥臣、松本洋太郎、中村智洋、三瀬広記、寶澤篤、和田淳、富岡佳久、阿部高明
- Organizer
  第63回　日本糖尿病学会年次集会
- Data Source
  KAKENHI-PROJECT-19K23994
[Presentation] 腸内細菌酵素由来のフェニル硫酸は糖尿病性腎臓病のアルブミン尿増悪の原因物質かつ進展予測マーカーである2019
- Author(s)
  菊地晃一
- Organizer
  第31回糖尿病性腎症研究会
- Data Source
  KAKENHI-PROJECT-19K23994
[Presentation] Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease (Part 1, Basic)2019
- Author(s)
  菊地晃一
- Organizer
  第52回米国腎臓学会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23994
[Presentation] 糖尿病性腎症の新規発症・進展予測マーカーとしてのフェニル硫酸の有用性の臨床検討2019
- Author(s)
  菊地晃一
- Organizer
  第10回腎不全研究会
- Data Source
  KAKENHI-PROJECT-19K23994

1. 三島英換

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 石井直人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 香川慶輝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 清治和将

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 高瀬圭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 豊原敬文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kikuchi Koichi 菊地 晃一

KIKUCHI Koichi 菊地 晃一

Research Projects

Research Products

Co-Researchers

糖尿病性腎臓病の新規バイオマーカーの確立と腸腎連関メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

糖尿病性腎臓病における腸腎連関の解明と新規DKDバイオマーカーの確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The clinical application of a novel biomarker and therapeutic strategy in diabetic kidney diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] (+)-Sesamin, a sesame lignan, is a potent inhibitor of gut bacterial tryptophan indole-lyase that is a key enzyme in chronic kidney disease pathogenesis.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SGLT‐1‐specific inhibition ameliorates renal failure and alters the gut microbial community in mice with adenine‐induced renal failure2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fibromuscular dysplasia with recurrence after "long-term" following percutaneous transcatheter renal angioplasty: two case reports with a review of 26 patients2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CE-MS-Based Identification of Uremic Solutes Specific to Hemodialysis Patients2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kidney enlargement effect of angioplasty for nonatherosclerotic renovascular disease: reversibility of ischemic kidney2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Germ-free conditions modulate host purine metabolism, exacerbating adenine-induced kidney damage.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Drugs Repurposed as Antiferroptosis Agents Suppress Organ Damage, Including AKI, by Functioning as Lipid Peroxyl Radical Scavengers2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The guanylate cyclase C agonist linaclotide ameliorates the gut?cardio?renal axis in an adenine-induced mouse model of chronic kidney disease2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 12.Urinary phenyl sulfate predict the 2-year ACR deterioration in a DKD cohort.2022

Author(s)

Organizer

Data Source

[Presentation] he gut microbiome-derived phenyl sulfate is a novel predictive marker and cause of albuminuria in diabetic kidney disease.2021

Author(s)

Organizer

Data Source

[Presentation] 糖尿病性腎症の発症・進展予測マーカーとしてのフェニル硫酸の有用性2020

Author(s)

Organizer

Data Source

[Presentation] Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease2020

Author(s)

Organizer

Data Source

[Presentation] The clinical importance of gut microbiome-derived phenyl sulfate as a predictive marker of albuminuria in diabetic kidney disease2020

Kikuchi Koichi 菊地晃一

KIKUCHI Koichi 菊地晃一