Ushimaru Richiro 牛丸理一郎

Researcher Number	10873648
Other IDs
Affiliation (Current)	2023: 東京大学, 大学院薬学系研究科(薬学部), 助教
Affiliation (based on the past Project Information) *help	2020 – 2023: 東京大学, 大学院薬学系研究科(薬学部), 助教
Review Section/Research Field	Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / 0801:Pharmaceutical sciences and related fields Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Transformative Research Areas, Section (II)
Keywords	Principal Investigator 生合成 / 天然物生合成 / 天然物化学 / 鉄酵素 / 非ヘム鉄酵素 / シクロプロパン / 非典型アミノ酸 / 酵素 / 天然物 / 酵素反応機構 / ヌクレオシド天然物 … More Except Principal Investigator … More 合成生物学 / 生合成工学 / 酵素 / 生合成 / 薬用天然物 / 遷移状態 / 酵素の精密構造機能解析 / 予知生合成化学 / 中国南西部 / 生物多様性 / 生合成マシナリー / 天然物生合成 / 創薬資源採集調査 / 天然物化学 / 酵素工学 Less

薬用天然物の複雑骨格構築を担う新奇生合成酵素を用いた革新的次世代型天然物創薬
- Principal Investigator
  
  阿部郁朗
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
微生物由来メチル基転移酵素阻害剤の生合成機構解明と物質生産への応用Principal Investigator
- Principal Investigator
  
  牛丸理一郎
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  The University of Tokyo
酵素機能発掘と合成生物学による次世代型物質生産系の構築
- Principal Investigator
  
  淡川孝義
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Institute of Physical and Chemical Research
  The University of Tokyo
シクロプロパン環含有アミノ酸を構築する非ヘム鉄酵素の触媒機構解明Principal Investigator
- Principal Investigator
  
  牛丸理一郎
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  The University of Tokyo
複雑骨格天然物生合成酵素の精密構造機能解析に基づく合成生物学と創薬
- Principal Investigator
  
  阿部郁朗
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Investigation into the heteroatom incorporation into nucleoside natural productsPrincipal Investigator
- Principal Investigator
  
  Ushimaru Richiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
新たな創薬資源の採集調査と新奇天然物生合成マシナリーの探索と解明
- Principal Investigator
  
  阿部郁朗
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo

All 2022 2021 2020

All Journal Article Presentation

[Journal Article] Stereodivergent Nitrocyclopropane Formation during Biosynthesis of Belactosins and Hormaomycins2021
- Author(s)
  Shimo Shotaro、Ushimaru Richiro、Engelbrecht Alicia、Harada Mei、Miyamoto Kazunori、Kulik Andreas、Uchiyama Masanobu、Kaysser Leonard、Abe Ikuro
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 44 Pages: 18413-18418
- DOI
  10.1021/jacs.1c10201
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22700, KAKENHI-PROJECT-17H06173, KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-21K14744, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-16H06276
[Journal Article] Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI2021
- Author(s)
  Mori Takahiro、Zhai Rui、Ushimaru Richiro、Matsuda Yudai、Abe Ikuro
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 4417-4417
- DOI
  10.1038/s41467-021-24685-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15703, KAKENHI-PROJECT-20K22700, KAKENHI-PROJECT-21K14744, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-16H06276
[Journal Article] Studies of lincosamide formation complete the biosynthetic pathway for lincomycin A2020
- Author(s)
  Wang Shao-An、Lin Chia-I、Zhang Jiawei、Ushimaru Richiro、Sasaki Eita、Liu Hung-wen
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 40 Pages: 24794-24801
- DOI
  10.1073/pnas.2009306117
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22700
[Journal Article] Identification of the Enzymes Mediating the Maturation of the Seryl‐tRNA Synthetase Inhibitor SB‐217452 during the Biosynthesis of Albomycins2020
- Author(s)
  Ushimaru Richiro、Chen Zhang、Zhao Houyuan、Fan Po‐hsun、Liu Hung‐wen
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 59 Issue: 9 Pages: 3558-3562
- DOI
  10.1002/anie.201915275
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] 非ヘム鉄酵素が触媒するシクロプロパン化反応の立体化学解析2022
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] 天然物生合成における新規ラジカル環化酵素の同定と反応機構解明2022
- Author(s)
  牛丸理一郎
- Organizer
  日本化学会第102春季年会若い世代の特別講演会
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 非ヘム鉄酵素が触媒するシクロプロパン化反応の立体化学解析2022
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 薬用トロパンアルカロイド生合成酵素の反応機構解析2022
- Author(s)
  牛丸理一郎
- Organizer
  日本薬学会第142年会薬用植物化学研究の新展開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] 薬用トロパンアルカロイド生合成酵素の反応機構解析2022
- Author(s)
  牛丸理一郎
- Organizer
  日本薬学会第142年会薬用植物化学研究の新展開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 天然物生合成における新規ラジカル環化酵素の同定と反応機構解明2022
- Author(s)
  牛丸理一郎
- Organizer
  日本化学会第102春季年会若い世代の特別講演会
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] Mechanistic Investigation of the H6H-catalyzed oxidation reactions using substrate analogues2021
- Author(s)
  Richiro Ushimaru, Ri-dao Chen, Xiao Liu, Po-shun Fan, and Hung-wen Liu
- Organizer
  4th European Conference on Natural Products
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] ホルマオマイシンの生合成におけるニトロシクロプロパン環の形成2021
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  2021年度(第35回)日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] ホルマオマイシンの生合成におけるニトロシクロプロパン環の形成2021
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  2021年度(第35回)日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] ホルマオマイシンの生合成におけるニトロシクロプロパン環の形成2021
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  日本生薬学会第67回年会
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 薬用トロパンアルカロイド生合成酵素の反応機構解析2021
- Author(s)
  牛丸理一郎
- Organizer
  日本生薬学会第67回年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] Assembly of the Peptidyl Thionucleoside during the Biosynthesis of Albomycins2021
- Author(s)
  Richiro Ushimaru
- Organizer
  The 3nd Lijiang International Forum on Pharmaceutical Sciences
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] Assembly of the Peptidyl Thionucleoside during the Biosynthesis of Albomycins2021
- Author(s)
  Richiro Ushimaru
- Organizer
  The 3nd Lijiang International Forum on Pharmaceutical Sciences
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] Mechanistic Investigation of the H6H-catalyzed oxidation reactions using substrate analogues2021
- Author(s)
  Richiro Ushimaru, Ri-dao Chen, Xiao Liu, Po-shun Fan, and Hung-wen Liu
- Organizer
  4th European Conference on Natural Products
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] チオヌクレオチド天然物の生合成2021
- Author(s)
  牛丸理一郎
- Organizer
  第23回　天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] 薬用トロパンアルカロイド生合成酵素の反応機構解析2021
- Author(s)
  牛丸理一郎
- Organizer
  日本生薬学会第67回年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] ホルマオマイシンを構成する3-(trans-2-ニトロシクロプロピル)アラニンの生合成2021
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  第23回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] ホルマオマイシンの生合成におけるニトロシクロプロパン環の形成2021
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  日本生薬学会第67回年会
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] ホルマオマイシンの生合成におけるニトロシクロプロパン環の形成2021
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] チオヌクレオチド天然物の生合成2021
- Author(s)
  牛丸理一郎
- Organizer
  第23回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] ホルマオマイシンを構成する3-(trans-2-ニトロシクロプロピル)アラニンの生合成2021
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  第23回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] Albomycin生合成におけるセリルtRNA合成酵素阻害剤SB-217452の形成2020
- Author(s)
  牛丸理一郎、Zhang Chen、Houyuan Zhao、Po-hsun Fan、Hung-wen Liu
- Organizer
  第62回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-20K22700

1. 阿部郁朗 (40305496)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 淡川孝義 (80609834)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. 森貴裕 (60734564)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results

Ushimaru Richiro 牛丸 理一郎

Research Projects

Research Products

Co-Researchers

薬用天然物の複雑骨格構築を担う新奇生合成酵素を用いた革新的次世代型天然物創薬

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

微生物由来メチル基転移酵素阻害剤の生合成機構解明と物質生産への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

酵素機能発掘と合成生物学による次世代型物質生産系の構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

シクロプロパン環含有アミノ酸を構築する非ヘム鉄酵素の触媒機構解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

複雑骨格天然物生合成酵素の精密構造機能解析に基づく合成生物学と創薬

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation into the heteroatom incorporation into nucleoside natural productsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新たな創薬資源の採集調査と新奇天然物生合成マシナリーの探索と解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Stereodivergent Nitrocyclopropane Formation during Biosynthesis of Belactosins and Hormaomycins2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Studies of lincosamide formation complete the biosynthetic pathway for lincomycin A2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of the Enzymes Mediating the Maturation of the Seryl‐tRNA Synthetase Inhibitor SB‐217452 during the Biosynthesis of Albomycins2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 非ヘム鉄酵素が触媒するシクロプロパン化反応の立体化学解析2022

Author(s)

Organizer

Data Source

[Presentation] 天然物生合成における 新規ラジカル環化酵素の同定と反応機構解明2022

Author(s)

Organizer

Data Source

[Presentation] 非ヘム鉄酵素が触媒するシクロプロパン化反応の立体化学解析2022

Author(s)

Organizer

Data Source

[Presentation] 薬用トロパンアルカロイド生合成酵素の 反応機構解析2022

Author(s)

Ushimaru Richiro 牛丸理一郎

[Presentation] 天然物生合成における新規ラジカル環化酵素の同定と反応機構解明2022

[Presentation] 薬用トロパンアルカロイド生合成酵素の反応機構解析2022

[Presentation] 薬用トロパンアルカロイド生合成酵素の反応機構解析2022

[Presentation] 天然物生合成における新規ラジカル環化酵素の同定と反応機構解明2022

[Presentation] 薬用トロパンアルカロイド生合成酵素の反応機構解析2021

[Presentation] 薬用トロパンアルカロイド生合成酵素の反応機構解析2021