Uchihara Yuki 内原脩貴

Researcher Number	10883712
Other IDs
Affiliation (based on the past Project Information) *help	2023 – 2024: 慶應義塾大学, 薬学部(芝共立), 助教 2021 – 2022: 群馬大学, 未来先端研究機構, 研究員
Review Section/Research Field	Principal Investigator Basic Section 63020:Radiation influence-related / Transformative Research Areas, Section (III)
Keywords	Principal Investigator DNA損傷修復 / クロマチン動態 / 53BP1 / 非典型的翻訳 / 次世代シーケンス解析 / HLAクラスI / 修復ナノドメイン / DNA二本鎖切断修復 / DNA二本鎖切断 / 超高解像度解析 / DNA修復

放射線誘発DNA二本鎖切断部位近傍における修復ナノドメインの構築原理と機能解明Principal Investigator
- Principal Investigator
  
  内原脩貴
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Keio University
DNA損傷依存的な非典型的翻訳産物の同定とその生理的意義の解明Principal Investigator
- Principal Investigator
  
  内原脩貴
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Keio University
Analysis of 53BP1 foci using super-resolution microscopy in response to radiation-induced DNA double-strand breaksPrincipal Investigator
- Principal Investigator
  
  Uchihara Yuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 63020:Radiation influence-related
- Research Institution
  Keio University
  Gunma University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Characterization of the signal transduction cascade for inflammatory gene expression in fibroblasts with ATM-ATR deficiencies after Ionizing radiation2024
- Author(s)
  Haruna Shunji、Okuda Ken、Shibata Akiko、Isono Mayu、Tateno Kohei、Sato Hiro、Oike Takahiro、Uchihara Yuki、Kato Yu、Shibata Atsushi
- Journal Title
  
  Radiotherapy and Oncology
  
  Volume: 194 Pages: 110198-110198
- DOI
  10.1016/j.radonc.2024.110198
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18232, KAKENHI-PROJECT-22K07659, KAKENHI-PROJECT-21K17888, KAKENHI-PUBLICLY-23H04247, KAKENHI-PROJECT-23K21749
[Journal Article] Inhibition of intracellular ATP synthesis impairs the recruitment of homologous recombination factors after ionizing radiation2024
- Author(s)
  Hayashi Ryota、Okumura Hikaru、Isono Mayu、Yamauchi Motohiro、Unami Daiki、Lusi Rahmartani Tania、Yamamoto Masamichi、Kato Yu、Uchihara Yuki、Shibata Atsushi
- Journal Title
  
  Journal of Radiation Research
  
  Volume: － Issue: 3 Pages: 263-271
- DOI
  10.1093/jrr/rrae005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18232, KAKENHI-PROJECT-21K17888, KAKENHI-PUBLICLY-23H04247, KAKENHI-PROJECT-23K21749
[Journal Article] Calreticulin Upregulation in Cervical Cancer Tissues From Patients After 10 Gy Radiation Therapy2023
- Author(s)
  Okada Kohei、Sato Hiro、Kumazawa Takuya、Mori Yasumasa、Permata Tiara Bunga Mayang、Uchihara Yuki、Noda Shin-ei、Suzuki Keiji、Ikota Hayato、Yokoo Hideaki、Gondhowiardjo Soehartati、Nakano Takashi、Ohno Tatsuya、Shibata Atsushi
- Journal Title
  
  Advances in Radiation Oncology
  
  Volume: 8 Issue: 3 Pages: 101159-101159
- DOI
  10.1016/j.adro.2022.101159
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17888, KAKENHI-PUBLICLY-21H05504, KAKENHI-PROJECT-20K21536, KAKENHI-PROJECT-23K21749
[Journal Article] 放射線照射により惹起されるHLAクラスⅠ提示の分子機構2022
- Author(s)
  内原脩貴、柴田淳史
- Journal Title
  
  放射線生物研究
  
  Volume: 57 Pages: 265-284
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K17888
[Journal Article] DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production2022
- Author(s)
  Uchihara Yuki、Permata Tiara Bunga Mayang、Sato Hiro、Kawabata-Iwakawa Reika、Katada Sayako、Gu Wenchao、Kakoti Sangeeta、Yamauchi Motohiro、Kato Reona、Gondhowiardjo Soehartati、Hosen Naoki、Yasuhara Takaaki、Shibata Atsushi
- Journal Title
  
  Molecular Cell
  
  Volume: 82 Issue: 14 Pages: 2557-2570.e7
- DOI
  10.1016/j.molcel.2022.04.030
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17888, KAKENHI-PUBLICLY-21H05504, KAKENHI-PROJECT-20K06875, KAKENHI-PROJECT-20K21536, KAKENHI-PROJECT-23K21749
[Journal Article] RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair2022
- Author(s)
  Yasuhara Takaaki、Kato Reona、Yamauchi Motohiro、Uchihara Yuki、Zou Lee、Miyagawa Kiyoshi、Shibata Atsushi
- Journal Title
  
  Cell Reports
  
  Volume: 38 Issue: 5 Pages: 110335-110335
- DOI
  10.1016/j.celrep.2022.110335
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04713, KAKENHI-PUBLICLY-20H04879, KAKENHI-PROJECT-20J12698, KAKENHI-PROJECT-20K21536, KAKENHI-PROJECT-21K17888, KAKENHI-PROJECT-20KK0339, KAKENHI-PUBLICLY-21H05504, KAKENHI-PROJECT-23K21749, KAKENHI-PROJECT-23K21750
[Journal Article] High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells2021
- Author(s)
  Permata Tiara Bunga Mayang、Sato Hiro、Gu Wenchao、Kakoti Sangeeta、Uchihara Yuki、Yoshimatsu Yukihiko、Sato Itaru、Kato Reona、Yamauchi Motohiro、Suzuki Keiji、Oike Takahiro、Tsushima Yoshito、Gondhowiardjo Soehartati、Ohno Tatsuya、Yasuhara Takaaki、Shibata Atsushi
- Journal Title
  
  Journal of Radiation Research
  
  Volume: 62 Issue: 5 Pages: 773-781
- DOI
  10.1093/jrr/rrab050
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08195, KAKENHI-PROJECT-17H04713, KAKENHI-PUBLICLY-20H04879, KAKENHI-PROJECT-20K21536, KAKENHI-PROJECT-21K17888, KAKENHI-PUBLICLY-21H05504, KAKENHI-PROJECT-23K21749, KAKENHI-PROJECT-23K21750
[Journal Article] Expression of non-homologous end joining factor, Ku80, is negatively correlated with PD-L1 expression in cancer cells after X-ray irradiation2021
- Author(s)
  Kumazawa Takuya、Mori Yasumasa、Sato Hiro、Permata Tiara、Uchihara Yuki、Noda Shin-Ei、Okada Kohei、Kakoti Sangeeta、Suzuki Keiji、Ikota Hayato、Yokoo Hideaki、Gondhowiardjo Soehartati、Nakano Takashi、Ohno Tatsuya、Shibata Atsushi
- Journal Title
  
  Oncology Letters
  
  Volume: 23 Issue: 1 Pages: 29-29
- DOI
  10.3892/ol.2021.13147
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08195, KAKENHI-PROJECT-17H04713, KAKENHI-PUBLICLY-20H04879, KAKENHI-PROJECT-20K21536, KAKENHI-PROJECT-21K17888, KAKENHI-PUBLICLY-21H05504, KAKENHI-PROJECT-23K21749
[Journal Article] Modulation of immune responses by DNA damage signaling2021
- Author(s)
  Uchihara Yuki、Permata Tiara Bunga Mayang、Sato Hiro、Shibata Atsushi
- Journal Title
  
  DNA Repair
  
  Volume: 104 Pages: 103135-103135
- DOI
  10.1016/j.dnarep.2021.103135
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04713, KAKENHI-PUBLICLY-20H04879, KAKENHI-PROJECT-20K21536, KAKENHI-PROJECT-21K17888, KAKENHI-PUBLICLY-21H05504, KAKENHI-PROJECT-23K21749
[Presentation] 53BP1およびRAP80による放射線誘発DNA二本鎖切断部位の高次クロマチン構造制御2023
- Author(s)
  内原脩貴、宇波大輝、林僚汰、奥村光遥、堅田明子、磯野真由、宮成悠介、安原崇哲、山内基弘、加藤優、柴田淳史
- Organizer
  日本放射線影響学会第66回大会
- Data Source
  KAKENHI-PUBLICLY-23H04247
[Presentation] 53BP1およびRAP80を介したDNA二本鎖切断部位の高次クロマチン構造制御2023
- Author(s)
  内原脩貴、柴田淳史
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K17888
[Presentation] 53BP1およびRAP80による放射線誘発DNA二本鎖切断部位の高次クロマチン構造制御2023
- Author(s)
  内原脩貴、宇波大輝、林僚汰、奥村光遥、堅田明子、磯野真由、宮成悠介、安原崇哲、山内基弘、加藤優、柴田淳史
- Organizer
  日本放射線影響学会第66回大会
- Data Source
  KAKENHI-PROJECT-21K17888
[Presentation] 53BP1およびRAP80を介したDNA二本鎖切断部位の高次クロマチン構造制御2023
- Author(s)
  内原脩貴、柴田淳史
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-23H04247
[Presentation] DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production2023
- Author(s)
  Yuki Uchihara, Tiara Bunga Mayang Permata, Hiro Sato, Reika Kawabata-Iwakawa, Sayako Katada, Wenchao Gu, Sangeeta Kakoti, Motohiro Yamauchi, Reona Kato, Soehartati Gondhowiardjo, Naoki Hosen, Takaaki Yasuhara, Atsushi Shibata
- Organizer
  The International Ataxia-Telangiectasia Workshop 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K17888
[Presentation] DNA損傷応答シグナル伝達を介したHLAクラスIの抗原提示2023
- Author(s)
  内原脩貴, Permata Tiara Bunga Mayang, 佐藤浩央, 川端麗香, 堅田明子, Gu Wenchao, Kakoti Sangeeta, 山内基弘, 加藤玲於奈, Gondhowiardjo Soehartati, 保仙直毅, 安原崇哲, 柴田淳史
- Organizer
  第143回日本薬学会年会
- Data Source
  KAKENHI-PROJECT-21K17888
[Presentation] DNA損傷が惹起するHLAクラスIの抗原提示の分子機構2022
- Author(s)
  内原脩貴, Permata Tiara, Bunga Mayang, 佐藤浩央, 川端麗香, 堅田明子, Gu Wenchao, Kakoti Sangeeta, 山内基弘, 加藤玲於奈, Gondhowiardjo Soehartati, 保仙直毅, 安原崇哲, 柴田淳史
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K17888
[Presentation] DNA損傷が惹起するATR-AKT-mTORC1-S6Kシグナル伝達経路を介したHLAクラスIの提示2022
- Author(s)
  内原脩貴, 柴田淳史
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K17888
[Presentation] DNA損傷シグナルに伴い活性化されるHLAクラスI提示の分子機構2022
- Author(s)
  内原脩貴, 柴田淳史
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K17888
[Presentation] DNA損傷シグナルによるHLAクラスIの抗原提示の分子メカニズム2022
- Author(s)
  内原脩貴, Permata Tiara Bunga Mayang, 佐藤浩央, 川端麗香, 堅田明子, Gu Wenchao, Kakoti Sangeeta, 山内基弘, 加藤玲於奈, Gondhowiardjo Soehartati, 保仙直毅, 安原崇哲, 柴田淳史
- Organizer
  2022年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-21K17888
[Presentation] 放射線照射により促進されるパイオニアラウンド翻訳を介したHLAクラスIの提示2022
- Author(s)
  内原脩貴, Permata Tiara Bunga Mayang, 佐藤浩央, 川端麗香, 堅田明子, Gu Wenchao, Kakoti Sangeeta, 山内基弘, 加藤玲於奈, Gondhowiardjo Soehartati, 保仙直毅, 安原崇哲, 柴田淳史
- Organizer
  日本放射線影響学会第65回大会
- Data Source
  KAKENHI-PROJECT-21K17888
[Presentation] DNA損傷が惹起するナンセンス変異依存mRNA分解機構を介した抗原産生およびHLAクラスIの提示2021
- Author(s)
  内原脩貴, Permata Tiara, Bunga Mayang, 佐藤浩央, 川端麗香, 堅田明子, Gu Wenchao, Kakoti Sangeeta, 山内基弘, 加藤玲於奈, Gondhowiardjo Soehartati, 保仙直毅, 安原崇哲, 柴田淳史
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K17888
[Presentation] 放射線照射により促進されるHLAクラスIの抗原提示の分子機構2021
- Author(s)
  内原脩貴, Permata Tiara, Bunga Mayang, 佐藤浩央, 川端麗香, 堅田明子, Gu Wenchao, Kakoti Sangeeta, 山内基弘, 加藤玲於奈, Gondhowiardjo Soehartati, 保仙直毅, 安原崇哲, 柴田淳史
- Organizer
  日本放射線影響学会第64回大会
- Data Source
  KAKENHI-PROJECT-21K17888

1. 柴田淳史

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
2. 佐藤浩央

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Uchihara Yuki 内原 脩貴

Research Projects

Research Products

Co-Researchers

放射線誘発DNA二本鎖切断部位近傍における修復ナノドメインの構築原理と機能解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

DNA損傷依存的な非典型的翻訳産物の同定とその生理的意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of 53BP1 foci using super-resolution microscopy in response to radiation-induced DNA double-strand breaksPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Characterization of the signal transduction cascade for inflammatory gene expression in fibroblasts with ATM-ATR deficiencies after Ionizing radiation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of intracellular ATP synthesis impairs the recruitment of homologous recombination factors after ionizing radiation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calreticulin Upregulation in Cervical Cancer Tissues From Patients After 10 Gy Radiation Therapy2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 放射線照射により惹起されるHLAクラスⅠ提示の分子機構2022

Author(s)

Journal Title

Data Source

[Journal Article] DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of non-homologous end joining factor, Ku80, is negatively correlated with PD-L1 expression in cancer cells after X-ray irradiation2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Modulation of immune responses by DNA damage signaling2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] 53BP1およびRAP80による放射線誘発DNA二本鎖切断部位の高次クロマチン構造制御2023

Author(s)

Organizer

Data Source

[Presentation] 53BP1およびRAP80を介したDNA二本鎖切断部位の高次クロマチン構造制御2023

Author(s)

Organizer

Data Source

[Presentation] 53BP1およびRAP80による放射線誘発DNA二本鎖切断部位の高次クロマチン構造制御2023

Author(s)

Organizer

Data Source

[Presentation] 53BP1およびRAP80を介したDNA二本鎖切断部位の高次クロマチン構造制御2023

Author(s)

Uchihara Yuki 内原脩貴