Yokoi Yuki 横井友樹

Researcher Number	10895824
Other IDs
Affiliation (Current)	2025: 北海道大学, 先端生命科学研究院, 助教
Affiliation (based on the past Project Information) *help	2025: 北海道大学, 先端生命科学研究院, 助教 2023: 北海道大学, 先端生命科学研究院, 助教 2021 – 2022: 北海道大学, 先端生命科学研究院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 59040:Nutrition science and health science-related / Basic Section 49070:Immunology-related
Keywords	Principal Investigator α-defensin / Paneth細胞 / うつ病 / 腸内細菌 / 腸脳相関 / 細胞間情報伝達 / 自然免疫 / 腸管粘膜免疫

「腸上皮－腸内細菌叢－脳」軸の理解に基づく食によるうつ病予防戦略の確立Principal Investigator
- Principal Investigator
  
  横井友樹
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Hokkaido University
Understanding the intestinal mucosal immune system through revealing mechanisms of Paneth cell secretionPrincipal Investigator
- Principal Investigator
  
  Yokoi Yuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Hokkaido University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Effects of exposure to the neonicotinoid pesticide clothianidin on α-defensin secretion and gut microbiota in mice2024
- Author(s)
  YONOICHI Sakura、HARA Yukako、ISHIDA Yuya、SHODA Asuka、KIMURA Mako、MURATA Midori、NUNOBIKI Sarika、ITO Makiko、YOSHIMOTO Ayano、MANTANI Youhei、YOKOYAMA Toshifumi、HIRANO Tetsushi、IKENAKA Yoshinori、YOKOI Yuki、AYABE Tokiyoshi、NAKAMURA Kiminori、HOSHI Nobuhiko
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 86 Issue: 3 Pages: 277-284
- DOI
  10.1292/jvms.23-0514
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K19846, KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-23K25004
[Journal Article] Decreased Paneth cell α-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiota2023
- Author(s)
  Nakamura Shunta、Nakamura Kiminori、Yokoi Yuki、Shimizu Yu、Ohira Shuya、Hagiwara Mizu、Song Zihao、Gan Li、Aizawa Tomoyasu、Hashimoto Daigo、Teshima Takanori、Ouellette Andre J.、Ayabe Tokiyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 3953-3953
- DOI
  10.1038/s41598-023-30997-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08409, KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-22KJ0054, KAKENHI-PROJECT-20K21610, KAKENHI-PROJECT-22K16009, KAKENHI-PROJECT-23K21439
[Journal Article] Antimicrobial Properties and Mode of Action of Cryptdin-4, a Mouse α-Defensin Regulated by Peptide Redox Structures and Bacterial Cultivation Conditions2023
- Author(s)
  Wang Yi、Song Yuchi、Yan Shaonan、Hiramine Rina、Ohnishi Yuki、Yokoi Yuki、Nakamura Kiminori、Kikukawa Takashi、Ayabe Tokiyoshi、Aizawa Tomoyasu
- Journal Title
  
  Antibiotics
  
  Volume: 12 Issue: 6 Pages: 1047-1047
- DOI
  10.3390/antibiotics12061047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-21H02891
[Journal Article] A Basic Study of the Effects of Mulberry Leaf Administration to Healthy C57BL/6 Mice on Gut Microbiota and Metabolites2023
- Author(s)
  Gan Li、Inamura Yuga、Shimizu Yu、Yokoi Yuki、Ohnishi Yuki、Song Zihao、Kumaki Yasuhiro、Kikukawa Takashi、Demura Makoto、Ito Masaaki、Ayabe Tokiyoshi、Nakamura Kiminori、Aizawa Tomoyasu
- Journal Title
  
  Metabolites
  
  Volume: 13 Issue: 9 Pages: 1003-1003
- DOI
  10.3390/metabo13091003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K04849, KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-21H02891
[Journal Article] Shorter sleep time relates to lower human defensin 5 secretion and compositional disturbance of the intestinal microbiota accompanied by decreased short-chain fatty acid production2023
- Author(s)
  Shimizu Yu、Yamamura Ryodai、Yokoi Yuki、Ayabe Tokiyoshi、Ukawa Shigekazu、Nakamura Koshi、Okada Emiko、Imae Akihiro、Nakagawa Takafumi、Tamakoshi Akiko、Nakamura Kiminori
- Journal Title
  
  Gut Microbes
  
  Volume: 15 Issue: 1 Pages: 2190306-2190306
- DOI
  10.1080/19490976.2023.2190306
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-22K16009, KAKENHI-PROJECT-21H02891
[Journal Article] Application of Benchtop NMR for Metabolomics Study Using Feces of Mice with DSS-Induced Colitis2023
- Author(s)
  Song Zihao、Ohnishi Yuki、Osada Seiji、Gan Li、Jiang Jiaxi、Hu Zhiyan、Kumeta Hiroyuki、Kumaki Yasuhiro、Yokoi Yuki、Nakamura Kiminori、Ayabe Tokiyoshi、Yamauchi Kazuo、Aizawa Tomoyasu
- Journal Title
  
  Metabolites
  
  Volume: 13 Issue: 5 Pages: 611-611
- DOI
  10.3390/metabo13050611
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-21H02891
[Journal Article] Hemodynamic response to intestinal pH stimulation measured with spectroscopic video imaging2022
- Author(s)
  Funane Tsukasa、Yokoi Yuki、Kikuchi Masashi、Shinozaki Ryuga、Ayabe Tokiyoshi、Atsumori Hirokazu、Nishimura Ayako、Nakamura Kiminori、Kandori Akihiko
- Journal Title
  
  Biomedical Physics & Engineering Express
  
  Volume: 9 Issue: 1 Pages: 017001-017001
- DOI
  10.1088/2057-1976/aca20a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-22KJ0033
[Journal Article] Efficient and simple genetic engineering of enteroids using mouse isolated crypts for investigating intestinal functions2022
- Author(s)
  Ohira Shuya、Yokoi Yuki、Ayabe Tokiyoshi、Nakamura Kiminori
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 637 Pages: 153-160
- DOI
  10.1016/j.bbrc.2022.11.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19120, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-22KJ0054
[Journal Article] Intestinal commensal microbiota and cytokines regulate Fut2 <sup>+</sup> Paneth cells for gut defense2022
- Author(s)
  Kamioka Mariko、Goto Yoshiyuki、Nakamura Kiminori、Yokoi Yuki、Sugimoto Rina、Ohira Shuya、Kurashima Yosuke、Umemoto Shingo、Sato Shintaro、Kunisawa Jun、Takahashi Yu、Domino Steven E.、Renauld Jean-Christophe、Nakae Susumu、Iwakura Yoichiro、Ernst Peter B.、Ayabe Tokiyoshi、Kiyono Hiroshi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 3 Pages: 1-10
- DOI
  10.1073/pnas.2115230119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03702, KAKENHI-PROJECT-20H03176, KAKENHI-PROJECT-20H04098, KAKENHI-PROJECT-21H02394, KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-21H02963, KAKENHI-PROJECT-20J11528, KAKENHI-PROJECT-21K15460, KAKENHI-PROJECT-21K19494, KAKENHI-PROJECT-19K17452, KAKENHI-PROJECT-18H05280
[Journal Article] Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model2021
- Author(s)
  Suzuki Kosuke、Nakamura Kiminori、Shimizu Yu、Yokoi Yuki、Ohira Shuya、Hagiwara Mizu、Wang Yi、Song Yuchi、Aizawa Tomoyasu、Ayabe Tokiyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 9915-9915
- DOI
  10.1038/s41598-021-89308-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02891, KAKENHI-PROJECT-21K15460
[Presentation] Selective Paneth cell granule secretion in response to pathogenic and commensal bacteria in enteric mucosal immunity2024
- Author(s)
  Yuki Yokoi, Shuya Ohira, Haruto Matsuoka, Shota Takemi, Tokiyoshi Ayabe, Kiminori Nakamura
- Organizer
  The 52nd Annual Meeting of the Japanese Society for Immunology
- Data Source
  KAKENHI-PROJECT-21K15460
[Presentation] 小腸上皮細胞機能の分子メカニズム解明に向けた高効率かつ簡便な遺伝子改変enteroidの作製法の確立2023
- Author(s)
  松下稜, 横井友樹, 大平修也, 松岡温音, 竹見祥大, 中村公則
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K15460
[Presentation] 病原菌と共生菌に対する選択的なPaneth細胞顆粒分泌調節による自然免疫と共生のメカニズム2023
- Author(s)
  横井友樹, 大平修也, 綾部時芳, 中村公則
- Organizer
  令和４年度北大細胞生物研究集会
- Data Source
  KAKENHI-PROJECT-21K15460
[Presentation] 食品が誘導するPaneth細胞αディフェンシンによる免疫と共生2022
- Author(s)
  綾部時芳, 横井友樹, 高桑明子, 中村公則
- Organizer
  第18回日本食品免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-21K15460
[Presentation] High-efficient genetic engineering of enteroids using mouse isolated crypts revealing the intestinal function2022
- Author(s)
  Shuya Ohira, Yuki Yokoi, Yuito Kaibori, Yu Shimizu, Tokiyoshi Ayabe, Kiminori Nakamura
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15460
[Presentation] 抗菌ペプチドαディフェンシンによる腸内細菌制御と健康2022
- Author(s)
  綾部時芳、横井友樹、清水由宇、中村公則
- Organizer
  日本食品・機械研究会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15460
[Presentation] Regulation of Paneth cell granule secretion by selective sensing of pathogenic and commensal bacteria in intestinal homeostasis2022
- Author(s)
  横井友樹, 大平修也, 松岡温音, 海堀唯人, 篠崎竜我, 綾部時芳, 中村公則
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K15460
[Presentation] 抗菌ペプチドから粘膜免疫を理解する2021
- Author(s)
  綾部時芳、横井友樹、中村公則
- Organizer
  第58回日本消化器免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15460
[Presentation] The mechanism of acetylcholine-induced Paneth cell secretory responses in innate enteric immunity2021
- Author(s)
  Yuki Yokoi、Shuya Ohira、Mani Kikuchi、Tokiyoshi Ayabe、Kiminori Nakamura
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K15460
[Presentation] ER Stress-Associated Misfolding of Paneth cell α-defensin Induces Dysbiosis and Ileitis in a Murine Model of Crohn’s disease2021
- Author(s)
  Yu Shimizu、Kiminori Nakamura、Aki Yoshii、Yuki Yokoi、Mani Kikuchi、Ryuga Shinozaki、Shunta Nakamura、Shuya Ohira、Rina Sugimoto、Tokiyoshi Ayabe
- Organizer
  World Microbe Forum 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15460
[Presentation] Paneth細胞顆粒分泌応答からみた食機能評価系の確立2021
- Author(s)
  横井友樹、中村公則、高桑明子、菊池摩仁、綾部時芳
- Organizer
  第17回日本食品免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-21K15460
[Presentation] Dynamics of Paneth Cell Granule Secretory Responses to Bacteria in Innate Enteric Immunity2021
- Author(s)
  Yuki Yokoi、Kiminori Nakamura、Shuya Ohira、Ryuga Shinozaki、Mani Kikuchi、Tokiyoshi Ayabe
- Organizer
  World Microbe Forum 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15460
[Presentation] The mechanism for effects of maternal high-fat diet on the development of Paneth cells in offspring2021
- Author(s)
  八塚夏美、杉本理菜、大平修也、横井友樹、菊池摩仁、綾部時芳、中村公則
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K15460
[Presentation] Simple and efficient genetic engineering of enteroids by using mouse isolated crypts2021
- Author(s)
  大平修也、横井友樹、菊池摩仁、八塚夏美、綾部時芳、中村公則
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K15460

1. ITO Masaaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. SATO Shintaro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 橋本大吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 綾部時芳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 中村公則

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results

Yokoi Yuki 横井 友樹

Research Projects

Research Products

Co-Researchers

「腸上皮－腸内細菌叢－脳」軸の理解に基づく食によるうつ病予防戦略の確立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Understanding the intestinal mucosal immune system through revealing mechanisms of Paneth cell secretionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Effects of exposure to the neonicotinoid pesticide clothianidin on α-defensin secretion and gut microbiota in mice2024

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Decreased Paneth cell α-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiota2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antimicrobial Properties and Mode of Action of Cryptdin-4, a Mouse α-Defensin Regulated by Peptide Redox Structures and Bacterial Cultivation Conditions2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Basic Study of the Effects of Mulberry Leaf Administration to Healthy C57BL/6 Mice on Gut Microbiota and Metabolites2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Shorter sleep time relates to lower human defensin 5 secretion and compositional disturbance of the intestinal microbiota accompanied by decreased short-chain fatty acid production2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Application of Benchtop NMR for Metabolomics Study Using Feces of Mice with DSS-Induced Colitis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hemodynamic response to intestinal pH stimulation measured with spectroscopic video imaging2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient and simple genetic engineering of enteroids using mouse isolated crypts for investigating intestinal functions2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intestinal commensal microbiota and cytokines regulate Fut2 <sup>+</sup> Paneth cells for gut defense2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decrease of α-defensin impairs intestinal metabolite homeostasis via dysbiosis in mouse chronic social defeat stress model2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] Selective Paneth cell granule secretion in response to pathogenic and commensal bacteria in enteric mucosal immunity2024

Author(s)

Organizer

Data Source

[Presentation] 小腸上皮細胞機能の分子メカニズム解明に向けた高効率かつ簡便な遺伝子改変enteroidの作製法の確立2023

Author(s)

Organizer

Data Source

[Presentation] 病原菌と共生菌に対する選択的なPaneth細胞顆粒分泌調節による自然免疫と共生のメカニズム2023

Author(s)

Organizer

Data Source

Yokoi Yuki 横井友樹