AKIYAMA Takahiko 秋山貴彦

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Akiyama Takahiko 秋山貴彦

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Researcher Number	10897052
Affiliation (Current)	2026: 熊本大学, 病院, 医員
Affiliation (based on the past Project Information) *help	2026: 熊本大学, 病院, 医員 2023 – 2024: 公益財団法人がん研究会, 有明病院大腸外科, 医員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator 腫瘍免疫 / がん関連線維芽細胞 / 免疫チェックポイント阻害薬 / 免疫チェックポイント阻害薬 / 骨髄由来免疫抑制細胞 / 線維化腫瘍 / 腫瘍微小環境 / 癌関連線維芽細胞

大腸癌における腫瘍間質構成因子としての細胞外マトリックスと癌関連線維芽細胞の意義Principal Investigator
- Principal Investigator
  
  秋山貴彦
- Project Period (FY)
  2026 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University
Elucidation of tumor immune microenvironment remodeling mechanisms targeting cancer-associated fibroblastsPrincipal Investigator
- Principal Investigator
  
  Akiyama Takahiko
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Japanese Foundation for Cancer Research

All 2024 2023 2022

All Journal Article

[Journal Article] Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment2024
- Author(s)
  Yonemura A、Semba T、Zhang J、Fan Y、Yasuda-Yoshihara N、Wang H、Uchihara T、Yasuda T、Nishimura A、Fu L、Hu X、Wei F、Kitamura F、Akiyama T、Yamashita K、Eto K、Iwagami S、Iwatsuki M、Miyamoto Y、Matsusaki K、Yamasaki J、Nagano O、Saya H、Song S、Tan P、Baba H、Ajani Jaffer A.、Ishimoto T
- Journal Title
  
  Cell Reports
  
  Volume: 43 Issue: 1 Pages: 113613-113613
- DOI
  10.1016/j.celrep.2023.113613
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K14572, KAKENHI-PROJECT-23K08113, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23H00410, KAKENHI-PROJECT-21H02766, KAKENHI-PROJECT-23K14621, KAKENHI-PROJECT-23K27689, KAKENHI-PROJECT-23K08051
[Journal Article] Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer2023
- Author(s)
  Kitamura F、Semba T、Yasuda-Yoshihara N、Yamada K、Nishimura A、Yamasaki J、Nagano O、Yasuda T、Yonemura A、Tong Y、Wang H、Akiyama T、Matsumura K、Uemura N、Itoyama R、Bu L、Fu L、Hu X、Wei F、Mima K、Imai K、Hayashi H、Yamashita Y、Miyamoto Y、Baba H、Ishimoto T
- Journal Title
  
  JCI Insight
  
  Volume: 8 Issue: 20
- DOI
  10.1172/jci.insight.163022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14572, KAKENHI-PROJECT-23K14621, KAKENHI-PROJECT-22K08756, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-22K16537, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27463, KAKENHI-PROJECT-23K27689, KAKENHI-PROJECT-21H02766
[Journal Article] The colon inflammatory index score can predict the survival outcome after resection of colorectal cancer: a retrospective multicentre study2023
- Author(s)
  Akiyama T, Miyamoto Y, Matsuda A, Tokunaga R, Ogawa K, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Sonoda H, Yamada T, Yoshida H, Baba H
- Journal Title
  
  Journal of Cancer Research and Clinical Oncology
  
  Volume: 149 Issue: 10 Pages: 7887-7894
- DOI
  10.1007/s00432-023-04770-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K14621
[Journal Article] Extracellular water to total body water ratio, a novel predictor of recurrence in patients with colorectal cancer2023
- Author(s)
  Horino Taichi、Tokunaga Ryuma、Miyamoto Yuji、Akiyama Takahiko、Daitoku Nobuya、Sakamoto Yuki、Ohuchi Mayuko、Ogawa Katsuhiro、Yoshida Naoya、Baba Hideo
- Journal Title
  
  Annals of Gastroenterological Surgery
  
  Volume: 8 Issue: 1 Pages: 98-106
- DOI
  10.1002/ags3.12728
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K14621, KAKENHI-PROJECT-22K07284
[Journal Article] A novel tdTomato transgenic mouse model to visualize FAP‐positive cancer‐associated fibroblasts2023
- Author(s)
  Wei F , Uchihara T , Yonemura A , Yasuda-Yoshihara N , Yasuda T , Semba T , Fukuda M , Akiyama T , Kitamura F , Kariya R , Yamasaki J , Aihara K , Yamashita K , Nagano O , Okada S , Baba H , Ishimoto T
- Journal Title
  
  The FEBS Journal
  
  Volume: - Issue: 10 Pages: 2604-2615
- DOI
  10.1111/febs.16712
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-20K08961, KAKENHI-PROJECT-21K19535, KAKENHI-PROJECT-23K14621, KAKENHI-PROJECT-23K06745, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27463
[Journal Article] Prognostic Significance of Systemic Inflammation Indices by KRAS Status in Patients with Metastatic Colorectal Cancer.2022
- Author(s)
  Miyamoto Y, Akiyama T, Kato R, Sawayama H, Ogawa K, Yoshida N, Baba H.
- Journal Title
  
  Dis Colon Rectum.
  
  Volume: － Issue: 8 Pages: e809-e817
- DOI
  10.1097/dcr.0000000000002392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08851, KAKENHI-PROJECT-23K14621

1. MIYAMOTO yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 山崎淳太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
3. 澤山浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

AKIYAMA Takahiko 秋山 貴彦

Akiyama Takahiko 秋山 貴彦

Research Projects

Research Products

Co-Researchers

大腸癌における腫瘍間質構成因子としての細胞外マトリックスと癌関連線維芽細胞の意義Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of tumor immune microenvironment remodeling mechanisms targeting cancer-associated fibroblastsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Mesothelial cells with mesenchymal features enhance peritoneal dissemination by forming a protumorigenic microenvironment2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The colon inflammatory index score can predict the survival outcome after resection of colorectal cancer: a retrospective multicentre study2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular water to total body water ratio, a novel predictor of recurrence in patients with colorectal cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel tdTomato transgenic mouse model to visualize FAP‐positive cancer‐associated fibroblasts2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic Significance of Systemic Inflammation Indices by KRAS Status in Patients with Metastatic Colorectal Cancer.2022

Author(s)

Journal Title

DOI

Data Source

AKIYAMA Takahiko 秋山貴彦

Akiyama Takahiko 秋山貴彦