Amagai Ryo 天貝諒

Researcher Number	10982390
Affiliation (Current)	2026: 東北大学, 医学系研究科, 非常勤講師
Affiliation (based on the past Project Information) *help	2025: 東北大学, 医学系研究科, 非常勤講師 2023 – 2024: 東北大学, 大学病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related / 0901:Oncology and related fields
Keywords	Principal Investigator 皮膚T細胞性リンパ腫 / ヒアルロン酸 / 菌状息肉症 / 細胞外マトリックス / 腫瘍関連マクロファージ / マトリックスメタロプロテアーゼ / 腫瘍随伴性M2マクロファージ / MMP1 / CXCL5 / ベキサロテン … More / 腫瘍随伴マクロファージ / PAI-1 / MMP-9 / LL-37 Less

The Hyaluronan Pathway in the Pathogenesis and Treatment of Cutaneous T-Cell LymphomaPrincipal Investigator
- Principal Investigator
  
  天貝諒
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Tohoku University
Elucidating the role of LL-37/matrix metalloproteinases signaling in mycosis fungoides mass formationPrincipal Investigator
- Principal Investigator
  
  天貝諒
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Tohoku University

All 2025 2024 2023

All Journal Article Presentation

[Journal Article] Two cases of advanced melanoma with <scp>BRAF L597</scp> mutation: Options for systemic treatment2025
- Author(s)
  Amagai Ryo、Fujimura Taku、Kambayashi Yumi、Takahashi‐Watanabe Manami、Yamazaki Emi、Tamabuchi Erika、Oka Kenta、Muto Yusuke、Hashimoto Akira、Asano Yoshihide
- Journal Title
  
  The Journal of Dermatology
  
  Volume: - Issue: 6 Pages: 1090-1093
- DOI
  10.1111/1346-8138.17718
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K19525
[Journal Article] Impact of Hyaluronic Acid on the Cutaneous T-Cell Lymphoma Microenvironment: A Novel Anti-Tumor Mechanism of Bexarotene2025
- Author(s)
  Ikawa Tetsuya、Yamazaki Emi、Amagai Ryo、Kambayashi Yumi、Sekine Mana、Takahashi Takuya、Asano Yoshihide、Fujimura Taku
- Journal Title
  
  Cancers
  
  Volume: 17 Issue: 2 Pages: 324-324
- DOI
  10.3390/cancers17020324
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08399, KAKENHI-PROJECT-23K19525
[Journal Article] An Evaluation of Prognostic Factors in Cutaneous Squamous Cell Carcinoma: A Single-Center Study of 237 Japanese Cases2025
- Author(s)
  Yamazaki Emi、Fujimura Taku、Takahashi-Watanabe Manami、Amagai Ryo、Tamabuchi Erika、Oka Kenta、Kambayashi Yumi、Hashimoto Akira、Omori Ryoko、Takahashi Takehiro、Asano Yoshihide
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 14 Issue: 4 Pages: 1243-1243
- DOI
  10.3390/jcm14041243
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08399, KAKENHI-PROJECT-23K15260, KAKENHI-PROJECT-23K19525, KAKENHI-PROJECT-24K11466
[Journal Article] Successful Treatment of Unresectable BRCA1 L63*-Mutated Basal Cell Carcinoma Invading the Parietal Bone with Cisplatin and Fluorouracil: A Case Report2024
- Author(s)
  Yoshida-Akai Saaya、Fujimura Taku、Amagai Ryo、Kambayashi Yumi、Hashimoto Akira、Terui Hitoshi、Oka Kenta、Watanabe-Takahashi Manami、Yamazaki Emi、Ohuchi Kota、Asano Yoshihide
- Journal Title
  
  Case Reports in Oncology
  
  Volume: 17 Issue: 1 Pages: 1050-1054
- DOI
  10.1159/000541160
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19525
[Journal Article] The Evaluation of Immune Checkpoint Inhibitors and BRAF/MEK Inhibitors in Different Therapy Lines for Metastatic Melanoma: A Retrospective Study2024
- Author(s)
  Okuda-Hiwatashi Saki、Amagai Ryo、Fujimura Taku、Kambayashi Yumi、Watanabe-Takahashi Manami、Yamazaki Emi、Tamabuchi Erika、Itabashi Chisato、Hashimoto Akira、Asano Yoshihide
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 13 Issue: 18 Pages: 5560-5560
- DOI
  10.3390/jcm13185560
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K19525
[Journal Article] Possible effects of plasminogen activator inhibitor‐1 on promoting angiogenesis through matrix metalloproteinase 9 in advanced mycosis fungoides2024
- Author(s)
  Fujimura Taku、Ohuchi Kentaro、Ikawa Tetsuya、Kambayashi Yumi、Amagai Ryo、Furudate Sadanori、Asano Yoshihide
- Journal Title
  
  Hematological Oncology
  
  Volume: 42 Issue: 1
- DOI
  10.1002/hon.3244
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K19525, KAKENHI-PROJECT-21K08318, KAKENHI-PROJECT-22K16275, KAKENHI-PROJECT-22K08399
[Journal Article] Decreased interleukin 4 serum levels correlate with plasminogen activator inhibitor-1 inhibitor TM5614 efficacy?in patients with malignant melanoma?refractory to anti-programmed cell death protein-1 antibodies: post hoc study of the TM5614-MM trial2024
- Author(s)
  Yamazaki Emi、Fujimura Taku、Takahashi-Watanabe Manami、Tada Satsuki、Kitayama Chisako、Amagai Ryo、Kambayashi Yumi、Watanabe Masahiro、Maekawa Masamitsu、Mano Nariyasu、Asano Yoshihide
- Journal Title
  
  British Journal of Dermatology
  
  Volume: 192 Issue: 1 Pages: 167-169
- DOI
  10.1093/bjd/ljae343
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08399, KAKENHI-PROJECT-23K19525, KAKENHI-PROJECT-24K11466
[Journal Article] Steroid-resistant Vogt-Koyanagi-Harada-like uveitis due to BRAF/MEK inhibitor, successfully treated with adalimumab2024
- Author(s)
  Takahashi-Watanabe Manami、Fujimura Taku、Amagai Ryo、Yamazaki Emi、Tamabuchi Erika、Akai Saaya、Kambayashi Yumi、Hashimoto Akira、Hashimoto Kazuki、Asano Yoshihide
- Journal Title
  
  European Journal of Dermatology
  
  Volume: 34 Issue: 4 Pages: 442-444
- DOI
  10.1684/ejd.2024.4730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K19525
[Journal Article] CIC-DUX4 Rearranged Sarcoma Presenting in the Skin: Case Report2024
- Author(s)
  Amagai Ryo、Fujimura Taku、Hashimoto Akira、Yoshida Shinichirou、Asano Yoshihide
- Journal Title
  
  Case Reports in Oncology
  
  Volume: 17 Issue: 1 Pages: 681-685
- DOI
  10.1159/000539501
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19525
[Journal Article] A phase II multicentre study of plasminogen activator inhibitor-1 inhibitor (TM5614) plus nivolumab for treating anti-programmed cell death 1 antibody-refractory malignant melanoma: TM5614-MM trial2024
- Author(s)
  Fujimura Taku、Yoshino Koji、Kato Hiroshi、Fukushima Satoshi、Ishizuki Shoichiro、Otsuka Atsushi、Matsushita Shigeto、Amagai Ryo、Muto Yusuke、Yamazaki Emi、Kambayashi Yumi、Yahata Takashi、Miyata Toshio、Fujisawa Yasuhiro、Asano Yoshihide
- Journal Title
  
  British Journal of Dermatology
  
  Volume: 191 Issue: 5 Pages: 691-697
- DOI
  10.1093/bjd/ljae231
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08399, KAKENHI-PROJECT-23K19525, KAKENHI-PROJECT-23K21386, KAKENHI-PROJECT-24K11466
[Journal Article] Radiation‐induced cutaneous squamous cell carcinoma showing a significant response to pembrolizumab: A case report2024
- Author(s)
  Takahashi‐Watanabe Manami、Fujimura Taku、Amagai Ryo、Ohuchi Kentaro、Yamazaki Emi、Tamabuchi Erika、Kuroki Shigeru、Kambayashi Yumi、Hashimoto Akira、Asano Yoshihide
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 51 Issue: 11 Pages: 1500-1503
- DOI
  10.1111/1346-8138.17221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K19525
[Journal Article] Three-Year Analysis of Adjuvant Therapy in Postoperative Melanoma including Acral and Mucosal Subtypes2024
- Author(s)
  Muto Yusuke、Kambayashi Yumi、Kato Hiroshi、Mizuhashi Satoru、Ito Takamichi、Maekawa Takeo、Ishizuki Shoichiro、Uchi Hiroshi、Matsushita Shigeto、Yamamoto Yuki、Yoshino Koji、Fujisawa Yasuhiro、Amagai Ryo、Ohuchi Kentaro、Hashimoto Akira、Fukushima Satoshi、Asano Yoshihide、Fujimura Taku
- Journal Title
  
  Cancers
  
  Volume: 16 Issue: 15 Pages: 2755-2755
- DOI
  10.3390/cancers16152755
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08399, KAKENHI-PROJECT-23K19525
[Journal Article] <scp>Vogt‐Koyanagi‐Harada</scp> disease‐like uveitis after drug therapy including <scp>BRAF</scp>/<scp>MEK</scp> inhibitors in melanoma patients with <scp>HLA‐DRB1</scp>*042023
- Author(s)
  Amagai Ryo、Fujimura Taku、Yamazaki Emi、Takahashi Manami、Tamabuchi Erika、Kambayashi Yumi、Hashimoto Akira、Hashimoto Kazuki、Asano Yoshihide
- Journal Title
  
  The Journal of Dermatology
  
  Volume: Online ahead of print Issue: 6 Pages: 17082-17082
- DOI
  10.1111/1346-8138.17082
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K19525
[Journal Article] CD25 expression could be a prognostic marker of bexarotene monotherapy for cutaneous T‐cell lymphomas2023
- Author(s)
  Yamamoto Jun、Ohuchi Kentaro、Amagai Ryo、Roh Yuna、Endo Junko、Chiba Hiromu、Tamabuchi Erika、Kambayashi Yumi、Hashimoto Akira、Asano Yoshihide、Fujimura Taku
- Journal Title
  
  Skin Health and Disease
  
  Volume: 3 Issue: 3
- DOI
  10.1002/ski2.222
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K19525, KAKENHI-PROJECT-22K08399
[Journal Article] LL-37 might promote local invasion of melanoma by activating melanoma cells and tumor-associated macrophages.2023
- Author(s)
  2.Ohuchi K, Ikawa T, Amagai R,Takahashi T, Roh Y, Endo J, Kambayashi Y, Asano Y, Fujimura T.
- Journal Title
  
  Cancers
  
  Volume: 15 Issue: 6 Pages: 1678-1678
- DOI
  10.3390/cancers15061678
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08318, KAKENHI-PROJECT-22K08399, KAKENHI-PROJECT-23K19525
[Presentation] デニロイキンジフチトクスで加療した皮膚T細胞性リンパ腫の４例2024
- Author(s)
  天貝諒、藤村卓、渡邉愛美、山﨑絵美、赤井紗彩、玉渕恵里佳、神林由美、橋本彰、浅野善英
- Organizer
  第123回日本皮膚科学会総会
- Data Source
  KAKENHI-PROJECT-23K19525
[Presentation] BRAF L597変異を有する根治切除不能悪性黒色腫2例の治療経験2024
- Author(s)
  天貝　諒、藤村　卓、神林由美、渡邉愛美、山崎絵美、岡　謙太、赤井紗彩、玉渕恵里佳、橋本　彰、浅野善英
- Organizer
  第88回日本皮膚科学会東部支部学術大会
- Data Source
  KAKENHI-PROJECT-23K19525
[Presentation] 当科における進行期メラノーマに対するニボルマブ+イピリムマブ併用療法の治療経験2023
- Author(s)
  天貝諒, 藤村卓, 板橋知怜, 千葉広夢, 大内謙太郎, 玉渕恵里佳, 神林由美, 橋本彰, 浅野善英
- Organizer
  日本皮膚悪性腫瘍学会学術大会　第39回
- Data Source
  KAKENHI-PROJECT-23K19525

1. 神林由美

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
2. 藤村卓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Amagai Ryo 天貝 諒

Research Projects

Research Products

Co-Researchers

The Hyaluronan Pathway in the Pathogenesis and Treatment of Cutaneous T-Cell LymphomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the role of LL-37/matrix metalloproteinases signaling in mycosis fungoides mass formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Two cases of advanced melanoma with <scp>BRAF L597</scp> mutation: Options for systemic treatment2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of Hyaluronic Acid on the Cutaneous T-Cell Lymphoma Microenvironment: A Novel Anti-Tumor Mechanism of Bexarotene2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An Evaluation of Prognostic Factors in Cutaneous Squamous Cell Carcinoma: A Single-Center Study of 237 Japanese Cases2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Successful Treatment of Unresectable BRCA1 L63*-Mutated Basal Cell Carcinoma Invading the Parietal Bone with Cisplatin and Fluorouracil: A Case Report2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Evaluation of Immune Checkpoint Inhibitors and BRAF/MEK Inhibitors in Different Therapy Lines for Metastatic Melanoma: A Retrospective Study2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Possible effects of plasminogen activator inhibitor‐1 on promoting angiogenesis through matrix metalloproteinase 9 in advanced mycosis fungoides2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decreased interleukin 4 serum levels correlate with plasminogen activator inhibitor-1 inhibitor TM5614 efficacy?in patients with malignant melanoma?refractory to anti-programmed cell death protein-1 antibodies: post hoc study of the TM5614-MM trial2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Steroid-resistant Vogt-Koyanagi-Harada-like uveitis due to BRAF/MEK inhibitor, successfully treated with adalimumab2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CIC-DUX4 Rearranged Sarcoma Presenting in the Skin: Case Report2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A phase II multicentre study of plasminogen activator inhibitor-1 inhibitor (TM5614) plus nivolumab for treating anti-programmed cell death 1 antibody-refractory malignant melanoma: TM5614-MM trial2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Radiation‐induced cutaneous squamous cell carcinoma showing a significant response to pembrolizumab: A case report2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Three-Year Analysis of Adjuvant Therapy in Postoperative Melanoma including Acral and Mucosal Subtypes2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <scp>Vogt‐Koyanagi‐Harada</scp> disease‐like uveitis after drug therapy including <scp>BRAF</scp>/<scp>MEK</scp> inhibitors in melanoma patients with <scp>HLA‐DRB1</scp>*042023

Author(s)

Journal Title

DOI

Amagai Ryo 天貝諒

[Presentation] デニロイキンジフチトクスで加療した皮膚T細胞性リンパ腫の４例2024