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MISHIMA Hiromu
三嶋 弘
Connect your ORCID iD
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Researcher Number
20034100
Other IDs
External Links
Affiliation (based on the past Project Information)
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2005: 広島大学, 大学院・医歯薬総合研究科, 教授
2004 – 2005: 広島大学, 大学院・医歯薬学総合研究科, 教授
2002: Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授
1996 – 2001: Hiroshima Univ.Sch.of Med.Professor, 医学部, 教授
1995: 広島大学, 医学部, 助教授
1988 – 1993: 広島大学, 医学部, 助教授
Review Section/Research Field
Principal Investigator
Ophthalmology
/
Ophthalmology
Except Principal Investigator
Ophthalmology
Keywords
Principal Investigator
網膜神経節細胞 / グルタミン酸 / 毛様体上皮 / 眼圧 / 培養網膜 / 神経細胞死 / VIP / PACAP / 神経保護 / 一酸化窒素
…
More
/ 一酸化窒素合成酵素 / 網膜 / nitric oxide / nitric oxide synthase / 緑内障 / BDNF / Wnt14 / Caspase-3 / cyclic AMP / griseolic acid / cyclic AMP系 / プロテインキナ-ゼC / イノシト-ル燐脂質代謝回転系 / 情報伝達系のクロ-スト-ク / 培養毛様体上皮 / プロテインキナ-ゼ C / プロテインキナ-ゼC(PKC) / イノシト-ル1、4、5ー三燐酸(IP3) / 眼圧調整機構 / Adenosine 3' : 5'-cyclic monophosphate (cAMP) / Protein kinase C (PKC) / Inositol phospholipid turnover system / Cross-talk between cellular signalling systems / Cultured ciliary epithelia (CE) / プロスタグランディン / 細胞内情報伝達系 / イノシトール1,4,5-三燐酸(IP_3) / サイクリックAMP(cAMP) / 血液眼房水柵 / イノシトール1,4,5・三燐酸(IP_3) / Prostaglandins / Intra-cellular signaling system / Inositol triphospholipid (IP_3) / Cyclic AMP (_cAMP) / Ciliary epithelia / Blood aqueous barrier / Intraocular pressure / カルシウムイオン / パッチクランプ法 / アシドーシス / プロテインキナーゼC / 血管作動性腸管ペプチド / Retinal culture / Neuronal death / Glutamate / Calcium ion / Patch-clamp / Acidosis / 磁気細胞分離システム / Thy-1 / 細胞培養 / 逆行性標識 / glutamate / retinal ganglion cell / magnetic cell sorter / 細胞内カルシウム濃度 / 発生 / 新規遺伝子 / differential display / retinal ganglion / glutamate neurotoxity / intracellular Ca^<2+> concentration / glutamate receptor / cDNA microarray / novel gene / 網膜神経節細胞死 / SAMマウス / NMDA受容体 / 抗体 / 神経節細胞死 / NOS / グルタミン酸受容体 / 網膜分化 / ODAG / glaucoma / retinal ganglion cell death / SAM mouse / NMDA receptor / antibody / 神経 / プロテオミクス / PDGFR / プロテオミクス解析 / 家鶏胚 / R28細胞 / 神経保護作用 / マススペストロメトリー / 組み合わせプロテオミクス解析 / cell-sorting system / 3次元培養 / protemiomcs / chick embryo / retina / R28 cells / neuroprotection / グリセオ-ル酸 / CAMP分解酵素阻害剤 / 形態学的変化 / 房水質循環動態 / 眼内移行 / メラニン色素 / cAMP分解酵素阻害剤 / 房水循環動態 / CAMP-poshodi esterase阻害剤 / 眼圧下降 / cAMP-phosphodiesterase inhibitor / intraocular pressure / Morphological change / aqueous humor dynamics / ocular penetration / melanin
…
More
Except Principal Investigator
RAD51B / 神経系 / 遺伝子損傷修復 / ノックアウトマウス / 胚性幹細胞 / 相同組み換え / Rad51B / ES細胞(胚性幹細胞) / 細胞周期 / Nervous system / recombinational repair / knockout mouse / embryonal stem cell / homologous recombination
Less
Research Projects
(
9
results)
Research Products
(
1
results)
Co-Researchers
(
12
People)
Project Start Year (Newest)
Project Start Year (Oldest)
Protein screening and analysis for the retina degeneration
Principal Investigator
Principal Investigator
MISHIMA Hiromu
Project Period (FY)
2004 – 2005
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Ophthalmology
Research Institution
HIROSHIMA UNIVERSITY
Molecular biological and molecular genetic studies in apoptosis of retinal ganglion cells and retinal differentiation.
Principal Investigator
Principal Investigator
MISHIMA Hiromu
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Ophthalmology
Research Institution
HIROSHIMA UNIVERSITY
Research of RAD51B in the pathogenesis of ocular vascular occlusive disease
Principal Investigator
MINAMOTO Atsushi
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Ophthalmology
Research Institution
HIROSHIMA UNIVERSITY
Neuroprotection for Cell Death of Retinal Ganglion Cells and Molecular Biological Study for Nervi-Regeneration
Principal Investigator
Principal Investigator
MISHIMA Hiromu
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Ophthalmology
Research Institution
Hiroshima University
Neurophysiological study for excitatory amino acids-induced neurotoxicity and apoptosis in cultured retinal neurons.
Principal Investigator
Principal Investigator
MISHIMA Hiromu
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Ophthalmology
Research Institution
HIROSHIMA UNIVERSITY
Neurophysiological examination in relationship of glaucomatous neurodegeneration and glutamate neurotoxicity
Principal Investigator
Principal Investigator
MISHIMA Hiromu
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Ophthalmology
Research Institution
HIROSHIMA UNIVERSITY
Ocular hypotensive effect and intra-cellular signal transduction system of prostaglardins.
Principal Investigator
Principal Investigator
MISHIMA Hiromu
Project Period (FY)
1992 – 1993
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Ophthalmology
Research Institution
HIROSHIMA UNIVERSITY
Roll of cellular Signalling systems on intraocular pressure regulation mechanisms.
Principal Investigator
Principal Investigator
MISHIMA Hiromu
Project Period (FY)
1990 – 1991
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Ophthalmology
Research Institution
Hiroshima University
Experimental Study on Changes of Intraocular Pressure by the Application of Griseolic Acid
Principal Investigator
Principal Investigator
MISHIMA Hiromu
Project Period (FY)
1988 – 1989
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Ophthalmology
Research Institution
HIROSHIMA UNIVERSITY
All
2005
All
Journal Article
[Journal Article] Neuroprotective effects of erythropoietin on glutamate and nitric oxide toxicity in primary cultured retinal ganglion cells.
2005
Author(s)
Yamasaki M, Mishima HK, et al.
Journal Title
Brain Research 1050
Pages
: 15-26
Data Source
KAKENHI-PROJECT-16591756
# of Projects (Dsc)
# of Projects (Asc)
1.
MINAMOTO Atushi
(10253072)
# of Collaborated Projects:
4 results
# of Collaborated Products:
0 results
2.
KIUCHI Yoshiaki
(40214738)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
3.
FURUMOTO Atsuhito
(80238691)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
4.
KOSAKA Toshiya
(50253084)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
5.
OKADA Koji
(80294578)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
6.
広田 篤
(10243560)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
7.
NIKAIDO Hirotoshi
(80237651)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
8.
KANAMOTO Takashi
(20359889)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
9.
SHIMADA Sigeaki
(30196480)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
10.
NAKANO Kensuke
(30164247)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
11.
鈴木 雅信
(40206529)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
12.
永田 淳士
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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