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MISHIMA Hiromu  三嶋 弘

ORCIDConnect your ORCID iD *help
Researcher Number 20034100
Other IDs
External Links
Affiliation (based on the past Project Information) *help 2005: 広島大学, 大学院・医歯薬総合研究科, 教授
2004 – 2005: 広島大学, 大学院・医歯薬学総合研究科, 教授
2002: Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授
1996 – 2001: Hiroshima Univ.Sch.of Med.Professor, 医学部, 教授
1995: 広島大学, 医学部, 助教授
1988 – 1993: 広島大学, 医学部, 助教授
Review Section/Research Field
Principal Investigator
Ophthalmology / Ophthalmology
Except Principal Investigator
Ophthalmology
Keywords
Principal Investigator
網膜神経節細胞 / グルタミン酸 / 毛様体上皮 / 眼圧 / 培養網膜 / 神経細胞死 / VIP / PACAP / 神経保護 / 一酸化窒素 … More / 一酸化窒素合成酵素 / 網膜 / nitric oxide / nitric oxide synthase / 緑内障 / BDNF / Wnt14 / Caspase-3 / cyclic AMP / griseolic acid / cyclic AMP系 / プロテインキナ-ゼC / イノシト-ル燐脂質代謝回転系 / 情報伝達系のクロ-スト-ク / 培養毛様体上皮 / プロテインキナ-ゼ C / プロテインキナ-ゼC(PKC) / イノシト-ル1、4、5ー三燐酸(IP3) / 眼圧調整機構 / Adenosine 3' : 5'-cyclic monophosphate (cAMP) / Protein kinase C (PKC) / Inositol phospholipid turnover system / Cross-talk between cellular signalling systems / Cultured ciliary epithelia (CE) / プロスタグランディン / 細胞内情報伝達系 / イノシトール1,4,5-三燐酸(IP_3) / サイクリックAMP(cAMP) / 血液眼房水柵 / イノシトール1,4,5・三燐酸(IP_3) / Prostaglandins / Intra-cellular signaling system / Inositol triphospholipid (IP_3) / Cyclic AMP (_cAMP) / Ciliary epithelia / Blood aqueous barrier / Intraocular pressure / カルシウムイオン / パッチクランプ法 / アシドーシス / プロテインキナーゼC / 血管作動性腸管ペプチド / Retinal culture / Neuronal death / Glutamate / Calcium ion / Patch-clamp / Acidosis / 磁気細胞分離システム / Thy-1 / 細胞培養 / 逆行性標識 / glutamate / retinal ganglion cell / magnetic cell sorter / 細胞内カルシウム濃度 / 発生 / 新規遺伝子 / differential display / retinal ganglion / glutamate neurotoxity / intracellular Ca^<2+> concentration / glutamate receptor / cDNA microarray / novel gene / 網膜神経節細胞死 / SAMマウス / NMDA受容体 / 抗体 / 神経節細胞死 / NOS / グルタミン酸受容体 / 網膜分化 / ODAG / glaucoma / retinal ganglion cell death / SAM mouse / NMDA receptor / antibody / 神経 / プロテオミクス / PDGFR / プロテオミクス解析 / 家鶏胚 / R28細胞 / 神経保護作用 / マススペストロメトリー / 組み合わせプロテオミクス解析 / cell-sorting system / 3次元培養 / protemiomcs / chick embryo / retina / R28 cells / neuroprotection / グリセオ-ル酸 / CAMP分解酵素阻害剤 / 形態学的変化 / 房水質循環動態 / 眼内移行 / メラニン色素 / cAMP分解酵素阻害剤 / 房水循環動態 / CAMP-poshodi esterase阻害剤 / 眼圧下降 / cAMP-phosphodiesterase inhibitor / intraocular pressure / Morphological change / aqueous humor dynamics / ocular penetration / melanin … More
Except Principal Investigator
RAD51B / 神経系 / 遺伝子損傷修復 / ノックアウトマウス / 胚性幹細胞 / 相同組み換え / Rad51B / ES細胞(胚性幹細胞) / 細胞周期 / Nervous system / recombinational repair / knockout mouse / embryonal stem cell / homologous recombination Less
  • Research Projects

    (9 results)
  • Research Products

    (1 results)
  • Co-Researchers

    (12 People)
  •  Protein screening and analysis for the retina degenerationPrincipal Investigator

    • Principal Investigator
      MISHIMA Hiromu
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Molecular biological and molecular genetic studies in apoptosis of retinal ganglion cells and retinal differentiation.Principal Investigator

    • Principal Investigator
      MISHIMA Hiromu
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Ophthalmology
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Research of RAD51B in the pathogenesis of ocular vascular occlusive disease

    • Principal Investigator
      MINAMOTO Atsushi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Neuroprotection for Cell Death of Retinal Ganglion Cells and Molecular Biological Study for Nervi-RegenerationPrincipal Investigator

    • Principal Investigator
      MISHIMA Hiromu
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Hiroshima University
  •  Neurophysiological study for excitatory amino acids-induced neurotoxicity and apoptosis in cultured retinal neurons.Principal Investigator

    • Principal Investigator
      MISHIMA Hiromu
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Neurophysiological examination in relationship of glaucomatous neurodegeneration and glutamate neurotoxicityPrincipal Investigator

    • Principal Investigator
      MISHIMA Hiromu
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Ocular hypotensive effect and intra-cellular signal transduction system of prostaglardins.Principal Investigator

    • Principal Investigator
      MISHIMA Hiromu
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  Roll of cellular Signalling systems on intraocular pressure regulation mechanisms.Principal Investigator

    • Principal Investigator
      MISHIMA Hiromu
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Hiroshima University
  •  Experimental Study on Changes of Intraocular Pressure by the Application of Griseolic AcidPrincipal Investigator

    • Principal Investigator
      MISHIMA Hiromu
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      HIROSHIMA UNIVERSITY

All 2005

All Journal Article

  • [Journal Article] Neuroprotective effects of erythropoietin on glutamate and nitric oxide toxicity in primary cultured retinal ganglion cells.2005

    • Author(s)
      Yamasaki M, Mishima HK, et al.
    • Journal Title

      Brain Research 1050

      Pages: 15-26

    • Data Source
      KAKENHI-PROJECT-16591756
  • 1.  MINAMOTO Atushi (10253072)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 2.  KIUCHI Yoshiaki (40214738)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  FURUMOTO Atsuhito (80238691)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  KOSAKA Toshiya (50253084)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  OKADA Koji (80294578)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  広田 篤 (10243560)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  NIKAIDO Hirotoshi (80237651)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  KANAMOTO Takashi (20359889)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  SHIMADA Sigeaki (30196480)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  NAKANO Kensuke (30164247)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  鈴木 雅信 (40206529)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  永田 淳士
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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