KODAMA Hiroshi 児玉洋

Researcher Number	20091449
Other IDs
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Affiliation (based on the past Project Information) *help	2011: 大阪府立大学, 大学院・生命環境科学研究科, 教授 2011: 大阪府立大学, 生命環境科学研究科, 教授 2010: 大阪府立大学, 生命環境研究科, 教授 2009: Osaka Prefecture University, 生命環境科学研究科, 教授 2005 – 2007: Osaka Prefecture University, Graduate School of Life & Environmental Sciences, Professor, 生命環境科学研究科, 教授 … More 2004: 大阪府立大学, 農学生命科学研究科, 教授 1992 – 1994: 大阪府立大学, 農学部, 助教授 1991: Hokkaido Univ. Fac. of Vet. Med. Asso. Professor, 獣医学部, 助教授 1990: Univ, of Osaka Prefecture, College of Agr, Asso, Prof., 農学部, 助教授 1988 – 1989: Fac. Vet. Med., Hokkaido Univ., 獣医学部, 助教授 1986 – 1987: 北海道大学, 獣医学部, 助手 Less
Review Section/Research Field	Principal Investigator 基礎獣医学 / Applied veterinary science / Applied veterinary science / Basic veterinary science/Basic zootechnical science Except Principal Investigator 基礎獣医学 / Applied veterinary science
Keywords	Principal Investigator ニジマス / CRP / Aeromonas salmonicida / マクロファージ / C反応性蛋白 / 穴あき病 / インネートイムニティー / 感染防御 / サイトカイン / ビブリオ病 … More / M-CSF / SAP / Lactococcus garvieae / ワクチン / レンサ球菌症 / Flavobacterium psychrophilum / Cー反応性蛋白 / 急性期蛋白 / マクロファ-ジ / 補体 / 血清アミロイドP成分 / ムラミルジペプチド / MDP / 細胞障害 / 共棲発酵微生物 / 粘液胞子虫性やせ病 / Enteromyxum leei / やせ病 / 粘液胞子虫 / 共棲発酵細菌 / 細菌内毒素 / Vibrio anguillarum / 造血幹細胞刺激因子 / ボツリヌスC_2毒素 / アクチン / 急性期蛋白質 / マクロファージコロニー刺激因子 / ADPリボシル化 / 増殖刺激因子 / 頭腎細胞 / マクロファージコロニー / 血清 / hematopoietic cell-stimulating factor / macrophage / botulinum C_2 toxin / actin / acute phase protein / 連鎖球菌症 / ブリ / 細菌結合性 / 糖脂質 / リポソーム / 酸性糖脂質 / 粘膜感染 / 腸管粘膜 / Lactococcus disease / Yellowtail / Bacterial adherence / glycosphingolipids / Fish vaccine / Protective immunity / Liposome / 非定型Aeromonas salmonicida / 冷水病 / 腐植物質 / 防御免疫 / 疾病予防 / アユ / コイ / innate immunity / ulcer disease / atypical Aeromonas salmonicida / cold water disease / humic substance / protective immunity / サケ科魚類 / ヘルペスウイルス / 病原性 / 腫瘍 / DNA-DNAハイブリダイゼーション / 制限酵素切断パターン / サケ科魚ヘルペスウイルス / H-83株 / OMV / ヘルペスウイルスサルモニス / 腫瘍原性 / salmonids / herpesvirus / pathogenicity / tumor / DNA-DNA hybridization / 伝染性造血器壊死症 / ヘルペスウイルス感染症 / 上皮嚢腫症 / 類結節症 / せっそう病 / アエロモナス・ハイドロフィラ感染症 / 伝染性造血器壊症 / 魚病 / ビブリオ / エロモナス / アジュバント / レンサ球菌 / エピテリオシスチス / Infectious hematopoietic necrosis / Herpesvirus infection / Epitheliocystis / Streptococcosis / Pasteurellosis / Vibriosis / Furunculosis / Aeromonas hydrophila infection … More Except Principal Investigator Vibrio Anguillarum / Aeromonas Salmonicida / ニュ-カッスル病ウイルス / バキュロウイルス / サケ科魚類 / C反応性蛋白 / ヘモアグルチニンーノイラミニダ-ゼ / 膜融合蛋白 / リコンビニナントワクチニアクウイルス / リコンビニナント鶏痘ウイルス / 感染防御 / 病原性 / 膜融合(下)蛋白 / F蛋白前駆体 / リコンビナントワクチニアウイルス / リコンビナント鶏痘ウイルス / バキユロウイルス / Newcastle disease virus / hemagglutinin-neuraminidase / fusion protein / recombinant vaccinia virus / recombinant fowlpox virus / baculovirus / protection / pathogenicity / ニジマスマクロファージ / ニジマスC反応性蛋白 / マダイ上皮嚢腫症 / ビブリオ属 / コイマクロファージ / Jov-1ウイルス / ニジマスELISA / エロモナス属 / 魚類の防御免疫機構 / 水生病原微生物の疫学 / ニジマスの防御免疫 / コイの防御免疫 / 腸炎ビブリオの疫学 / 養殖貝類の微生物汚染 / ELISA / タイの上皮嚢腫症 / Rainbow trout macrophage / Rainbow trout C reactive protein / Red sea bream epitheliocystis / Vibrio sp / Aeromonas sp / Carp macrophage / JOV-1 virus / ボツリヌス神経毒素 / 神経伝達機構 / アセチルコリンの放出阻害 / シナプトゾーム / 毒性発現機構 / 細胞内侵入 / 細胞内代謝応答 / ADP-リボシル化反応 / シサプトゾーム / 毒性発現機序 / Boutulinum nerotoxin / Neurotransmitter system / Inhibition of acetylcholine release / Synaptosomes / Development mechanism of toxicity / マクロファージ / 化学発光 / 補体活性化 / 細菌内毒素 / 防御免疫機構 / Vibrio anguillarum / 魚類のビブリオ病 / エンドトキシン / Salmonids / Macrophage / Chemiluminescence / C-Reactive Protein / Activation of Complement / リコンビナントウイルス / 鶏痘ウイルス / 七面鳥ヘルペスウイルス / チミジンキナ-ゼ / マレック病ウイルス / ヘマグルチニンノイラミニダ-ゼ / カイコ多核体ウイルス / チミジンキナーゼ / ニューカッスル病ウイルス / ヘマグルチニンノイラミニダーゼ / 家禽病リコンビナントワクチン / 遺伝子組み換え / 鶏痘ウィルス / 七面鳥ヘルペスウィルス / Recombinant Virus / Fowl Pox Virus / Herpesvirus of Turkey / Thymidine Kinase / Newcastle Disease Virus / Marek's Disease Virus / Baculovirus / マレック病 / 腫瘍免疫 / 胎仔性抗原 / Tリンパ球表面抗原 / マレック病腫瘍付随表面抗原 / 可移植性マレック病腫瘍 / 栓球抗原 / 単クロ-ン性抗体 / MATSA / 単クローン性抗体 / Marek's disease / Tumor immunity / fetal antigen / T lymphocyte antigen / Marek's disease tumor associated antigen / transplantable Marek's disease tumor / thrombocyte antigen / monoclonal antibody Less

Protection of infectious diseases of fish by co-cultured microbial productPrincipal Investigator
- Principal Investigator
  
  KODAMA Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Osaka Prefecture University
Induction of innate immunity in fish by humus extract and its protective effectPrincipal Investigator
- Principal Investigator
  
  KODAMA Hiroshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Osaka Prefecture University
Innate immunity and protective immune responses in yellowtail induced by liposome-type Lactococcus garvieae vaccinePrincipal Investigator
- Principal Investigator
  
  KODAMA Hiroshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Osaka Prefecture University
Production of immune regulatory humoral factor in fish and role in protective immune reaclionsPrincipal Investigator
- Principal Investigator
  
  KODAMA Hiroshi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  University of Osaka Prefecture
魚類の感染防御免疫における免疫応答調節因子の役割Principal Investigator
- Principal Investigator
  
  児玉洋
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  基礎獣医学
- Research Institution
  Osaka Prefecture University
魚類のC反応性蛋白質遺伝子の発現と防御免疫における役割Principal Investigator
- Principal Investigator
  
  児玉洋
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  基礎獣医学
- Research Institution
  Osaka Prefecture University
Studies of the ecology and pathogenicity of Newcastle disease virus.
- Principal Investigator
  
  MIKAMI Takeshi
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Applied veterinary science
- Research Institution
  The university of Tokyo
魚類の免疫特性に関する研究エンドトキシンに対する抵抗性機序Principal Investigator
- Principal Investigator
  
  児玉洋
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  基礎獣医学
- Research Institution
  Hokkaido University
Studies on the protective mechanisms of fish against microbialdiseases. with special references on the development of vaccinesPrincipal Investigator
- Principal Investigator
  
  KODAMA H.
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Applied veterinary science
- Research Institution
  Hokkaido University
The Role of Tumor-Associated Antigen in Tumor Immunity
- Principal Investigator
  
  MIKAMI Takeshi
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  基礎獣医学
- Research Institution
  The University of Tokyo
Basic Research on the Development of Recombinant Vaccines for Animals by Genetic Engineering
- Principal Investigator
  
  SATO Fumiaki
- Project Period (FY)
  1987 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  基礎獣医学
- Research Institution
  Hokkaido University
ACTION OF BOTULINUM NEUROTOXIN ON ACETYLCHOLINE RELEASE FROM SYNAPTOSOMES
- Principal Investigator
  
  伊沢久夫, KUBO SHUICHIRO
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  基礎獣医学
- Research Institution
  Hokkaido University
Basic and practical studies on the immunological prevention of salmonids against bacterial diseases
- Principal Investigator
  
  IZAWA Hisao
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Hokkaido University
Oncogenicity of fish herpesvirus and protective immune mechanisms of fishPrincipal Investigator
- Principal Investigator
  
  KODAMA Hiroshi
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Applied veterinary science
- Research Institution
  Hokkaido University
Studies on mechanisms of protective immunity of fish and dissemination of pathogenic microorganisms in aquatic environment.
- Principal Investigator
  
  IZAWA Hisao
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  基礎獣医学
- Research Institution
  Hokkaido University

All 2011 2010 2007 2006 Other

All Journal Article Presentation

[Journal Article] Protection against atypical Aeromonas salmonicida infection in common carpby oral administration of a mixed microbial culture of Lactobacillus paracasei, Pithia membranifaciens and Saccharomyces cereviciae.2011
- Author(s)
  Kodama, H., Nakamura, H., Kashima, M., Iwasaki, T. and Togase, H.
- Journal Title
  
  J. Vet. Med. Sci.
  
  Volume: 73 Pages: 1319-1325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580378
[Journal Article] トラフグの粘液胞子虫性やせ病の病態と,酵母・乳酸菌共棲発酵培養物による予防2011
- Author(s)
  児玉洋
- Journal Title
  
  MPアグロジャーナル
  
  Volume: 第6号 Pages: 20-24
- NAID
  40020266650
- Data Source
  KAKENHI-PROJECT-21580378
[Journal Article] Protection against atypical Aeromonas salmonicida infection in common carp by oral administration of a mixed microbial culture of Lactobacillus paracasei, Pichia membranifaciens and Saccharomyces cereviciae2011
- Author(s)
  Kodama, H., et al
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 73 Pages: 1319-1325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21580378
[Journal Article] Protection against atypical Aeromonas salmonicida infection in carp by oral administration of humus extract2007
- Author(s)
  Kodama, H., Denso and Nakagawa, T.
- Journal Title
  
  Journal of Veterinary Medical Science 69
  
  Pages: 405-408
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580311
[Journal Article] In vitro enhancement of CpG ODN of phagocytic activity of rainbow trout head kidney phagocytes against fish pathogen Vibrio ordalii, but not against polystyrene particles2007
- Author(s)
  Nakatani, M., Iwasaki, T., Watarai, S. and Kodama, H.
- Journal Title
  
  J. Vet. Med. Sci. 69
  
  Pages: 1287-1290
- NAID
  110006569954
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580311
[Journal Article] Antitumor effect of humus extract on murine transplantable L1210 leukemia2007
- Author(s)
  Kodama, H. and Denso
- Journal Title
  
  Journal of Veterinary Medical Science 69
  
  Pages: 1069-1071
- NAID
  110006418728
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580311
[Journal Article] Antitumor effect of humus extract on murine transplantable L1210 leukemia2007
- Author(s)
  Kodama, H., Denso
- Journal Title
  
  Joural of Veterinary Medical Science 69
  
  Pages: 1069-1071
- NAID
  110006418728
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580311
[Journal Article] Protection against atypical Aeromonas salmonicida infection in carp by oral administration of humus extract2007
- Author(s)
  Kodama, H., Donso, Nakagawa, T.
- Journal Title
  
  Journal of Veterinary Medical Science 69・4
  
  Pages: 405-408
- Data Source
  KAKENHI-PROJECT-18580311
[Journal Article] Protection against atypical Aeromonas salmonicida infection in carp by oral administration of humus extract2007
- Author(s)
  Kodama, H., Denso, Nakagawa, T
- Journal Title
  
  Joural of Veterinary Medical Science 69
  
  Pages: 405-408
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580311
[Journal Article] In vitro Enhancement of CpG ODN of phagocytic activity of rainbow trout head kidney phagocytes against fish pathogen Vibrio ordalii, but not against polystylene particles2007
- Author(s)
  Nakatani, M., Iwasaki, T., Watarai, S., Kodama, H
- Journal Title
  
  Joural of Veterinary Medical Science 69
  
  Pages: 1287-1290
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18580311
[Journal Article] Protection against atypical Aeromonas salmonicida infection in carp by oral administration of humus extract2007
- Author(s)
  Kodama, H., Denso and Nakagawa, T.
- Journal Title
  
  J. Vet. Med. Sci. 69
  
  Pages: 405-408
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580311
[Journal Article] Antitumor effect of humus extract on murine transplantable L1210 leukemia2007
- Author(s)
  Kodama, H. and Denso
- Journal Title
  
  J. Vet. Med. Sci. 69
  
  Pages: 1069-1071
- NAID
  110006418728
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18580311
[Journal Article] Adherence of Lactococcus garvieae to the intestinal and brain gangliosides of the yellowtail2006
- Author(s)
  Shima, T., Kodama, H., Iwasaki, T., Watarai, S., Asagi, M.
- Journal Title
  
  Journal of Fish Diseases 29
  
  Pages: 249-253
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580254
[Journal Article] Adherence of Lactococcus garvieae to the intestinal and brain gangliosides of the yellowtail
- Author(s)
  Shima, T., Kodama, H., Iwasaki, T., Watarai, S., Asagi, M.
- Journal Title
  
  Journal of Fish Diseases (In press)
- Data Source
  KAKENHI-PROJECT-16580254
[Presentation] トラフグにおける粘液胞子虫性やせ病の病態と血液性状値解析2011
- Author(s)
  大谷健太, 矢賀部和也, 岩崎忠, 児玉洋, 堀谷勇介, 竹中重雄, 栂瀬英夫
- Organizer
  第152回日本獣医学会
- Place of Presentation
  堺
- Year and Date
  2011-09-20
- Data Source
  KAKENHI-PROJECT-21580378
[Presentation] 酵母・乳酸菌混合培養物による非特異免疫応答増強2010
- Author(s)
  児玉祥, 加島実, 中村秀顕, 岩崎忠, 栂瀬英夫
- Organizer
  第149回日本獣医学会
- Place of Presentation
  武蔵野
- Year and Date
  2010-03-26
- Data Source
  KAKENHI-PROJECT-21580378
[Presentation] 酵母・乳酸菌混合培養物による非特異免疫応答増強効果2010
- Author(s)
  児玉洋, 加島実, 中村秀顕, 岩崎忠, 栂瀬英夫
- Organizer
  第149回日本獣医学会
- Place of Presentation
  武蔵野
- Year and Date
  2010-03-26
- Data Source
  KAKENHI-PROJECT-21580378
[Presentation] Protection against fish infectious diseases by oral administration of a co-cultured product of bacteria and yeast2010
- Author(s)
  Kodama, H., Nakamura, H., Kashima, M., Iwasaki, T. and Togase, H.
- Organizer
  9th Int. Vet. Immunol. Symp.
- Place of Presentation
  Tokyo
- Year and Date
  2010-08-16
- Data Source
  KAKENHI-PROJECT-21580378
[Presentation] Protection against fish infectious diseases by oral administration of a co-cultured product of bacteria and yeast2010
- Author(s)
  Kodama, H., Nakamura, H., Kashima, M., Iwasaki, T., Togase, H.
- Organizer
  9^<th> Int.Vet.Immunol.Symp.
- Place of Presentation
  Tokyo
- Year and Date
  2010-08-16
- Data Source
  KAKENHI-PROJECT-21580378

1. MIKAMI Takeshi (20091506)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. IZAWA Hisao (50072351)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. KIDA Hiroshi (10109506)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. ONUMA Misao (70109510)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. BABA Tsuyoshi (30081540)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. HIRAI Katsuya (30021702)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KUBO SHUICHIRO (40001515)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. MATSUURA Yoshiharu (50157252)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KAWAKITA Masao (00012740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAGAI Yoshiyuki (20022874)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAGABAYASHI Toshihiko (10106700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KUMAZAWA Norichika H. (00039926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SYUTO BUNEI (60001533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SATO Fumiaki (10162471)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HAYASHI Masanobu (10130337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KUWABARA Mikinori (10002081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 遠藤大二 (40168828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KITAO T. (60094075)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. AZUMA I. (50028411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. ITAKURA C. (30021695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. TOHYA Yukinobu (20180119)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. AZETAKA Masayuki (10134503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. TAKAHASHI Eiji (50183439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. TAKAHASHI Michio (30011943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KODAMA Hiroshi 児玉 洋

Research Projects

Research Products

Co-Researchers

Protection of infectious diseases of fish by co-cultured microbial productPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Induction of innate immunity in fish by humus extract and its protective effectPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Innate immunity and protective immune responses in yellowtail induced by liposome-type Lactococcus garvieae vaccinePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Production of immune regulatory humoral factor in fish and role in protective immune reaclionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

魚類の感染防御免疫における免疫応答調節因子の役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

魚類のC反応性蛋白質遺伝子の発現と防御免疫における役割Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies of the ecology and pathogenicity of Newcastle disease virus.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

魚類の免疫特性に関する研究 エンドトキシンに対する抵抗性機序Principal Investigator

Principal Investigator

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Studies on the protective mechanisms of fish against microbialdiseases. with special references on the development of vaccinesPrincipal Investigator

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The Role of Tumor-Associated Antigen in Tumor Immunity

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Basic Research on the Development of Recombinant Vaccines for Animals by Genetic Engineering

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ACTION OF BOTULINUM NEUROTOXIN ON ACETYLCHOLINE RELEASE FROM SYNAPTOSOMES

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Basic and practical studies on the immunological prevention of salmonids against bacterial diseases

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KODAMA Hiroshi 児玉洋

魚類の免疫特性に関する研究エンドトキシンに対する抵抗性機序Principal Investigator