Onozaki Kikuo 小野嵜菊夫

… Alternative Names

ONOZAKI Kikuo 小野嵜菊夫

小野崎菊夫オノザキキクオ

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Researcher Number	20101313
Affiliation (Current)	2025: 名古屋市立大学, 大学院薬学研究科, 教授
Affiliation (based on the past Project Information) *help	2007 – 2010: 名古屋市立大学, 大学院・薬学研究科, 教授 2005 – 2006: 名古屋市立大学, 大学院薬学研究科, 教授 2002 – 2005: 名古屋市立大学, 大学院・薬学研究科, 教授 2002: Grad. Sch. Pharm. Sci., Prof., 薬学研究科, 教授 1999 – 2001: 名古屋市立大学, 薬学部, 教授 … More 1992 – 1997: 名古屋市立大学, 薬学部, 教授 1989 – 1990: 名古屋市立大学, 薬学部, 教授 1986: 筑波大学, 基礎医学系, 助教授 Less
Review Section/Research Field	Principal Investigator Biological pharmacy / Biological Sciences / Biological pharmacy / Environmental pharmacy Except Principal Investigator Environmental pharmacy / Biological pharmacy / Environmental pharmacy / Biological pharmacy / Immunology / Science and Engineering
Keywords	Principal Investigator IL-1 / サイトカイン / ODC / cytokine / TLR / メラノーマ / インターロイキン1 / アンチザイム / IL-1レセプター / CHOP … More / IL-1 receptor / melanoma / interleukin 1 / IL-6 / TGFβ / antizyme / 細胞増殖 / IL-1Ra / signal transduction / タバコ / 化学物質 / 関節リウマチ / シアル酸 / TNF / TRB3 / sialic acid / インターロイキンレセプター / エストロゲン / Sp1 / IL-1R / arteficial glycoprotein / glycotechnology / neoglycoprotein / 糖 / インターロイキン / 人工糖蛋白 / 糖鎖工学 / ネオグリコプロテイン / polyamine / cell growth / interleukin 1 receptor / Interleukin 1 / レセプター / インターロイギン1 / ポリアミン / シグナル伝達 / インターロイキン1レセプター / active oxygens / interleukin6 / cell growth inhibition / マクロファージ / 活性酸素 / インターロイキン6 / 細胞増殖抑制 / amniotic fluid / cell cycle / myeloid leukemia cell / myeloma cell / growth regulation / インタ-ロイキン6 / プロスタグランジンE_2 / 増殖分化 / インタ-ロイキン1 / 細胞周期 / 羊水 / プロスタグランジン / cAMP / 骨髄性白血病細胞 / 増殖・分化 / インタ-ロイキシン1 / 自己免疫 / 性ホルモン / 炎症性サイトカイン / 多環芳香属化合物 / 多環芳香族化合物 / IL-8 / ネオグライコプロテイン / 癌 / TNFα / 細胞傷害性 / 細胞障害性 / ワクチン / 毒力 / 抗酸菌 … More Except Principal Investigator サイトカイン / インターロイキン1 / 結核菌 / Smad / TGFβ / p300 / ATF4 / CHOP / TRB3 / toll like receptor / proteasome / E3 ligase / Smurf / cAMP / 病原性 / ワクチン / プロテアソーム / Vaccine / Antibiotics / Drug resistance / Interleukin / Cytokine / Cytotoxicity / Pathogenesis, Virulence / Mycobacterium tuberculosis / 一酸化窒素 / 抗菌剤 / 薬剤耐性 / インターロイキン / 細胞障害 / neurodegenerative diseases / diabetes / apoptosis / endoplasmic reticulum stress / Akt / ネガティブ・フィードバック / 神経変性疾患 / 糖尿病 / アポトーシス / 小胞体ストレス / cytokine / fibroblast / interleukin 1 / tuberculosis / スクリーニング / 抗結核薬 / toll like reseptors / toll like reccptors / IL-1R関連レセプター / 抗酸菌 / 線維芽細胞 / acetylation / ubiquitination / Roc1 / smurf / タンパク分解 / ユビキチンリカーゼ / smad3 / phosphorylation / ubiquitin / TGFbeta / アセチル化 / ユビキチン化 / signal transduction / astrocytes / IL-8 / IL-6 / IL-1 / コレラトキシン / IL6 / IL1 / 情報伝達機構 / アストロサイト / ILー8 / ILー6 / ILー1 / 骨髄性白血病細胞 / ヒトメラノーマ細胞 / 感染症学 / 微生物 / endocrine disrupters / arylhydrocarbon receptor / synoviocyte / promoter / HIV-1 / Interleukin 1 / estrogen receptor / estradiol / 転写 / HIV / Sp1 / エストロゲン受容体 / 関節リウマチ / 内分泌攪乱物質 / リン酸化 / BMP / 癌原性 / 細胞接着分子 / インターロイキン6 / メラノーマ Less

Regulatory mechanism of the induction and function of IL-1Principal Investigator
- Principal Investigator
  
  ONOZAKI Kikuo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagoya City University
Relation of the cytotoxic effect of Mycobacterium tuberculosis on host cells and the signal transduction from interlukin 1 (IL-1) receptor and IL-1R related receptors
- Principal Investigator
  
  TAKII Takemasa
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Nagoya City University
関節リウマチと化学物質に関する研究Principal Investigator
- Principal Investigator
  
  小野嵜菊夫 (小野崎菊夫)
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Environmental pharmacy
- Research Institution
  Nagoya City University
Analysis of the cytotoxicity of virulent Mycobacterium tuberculosis to human fibroblast cells
- Principal Investigator
  
  TAKII Takemasa
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University
抗腫瘍活性の増強と毒性軽減を示す糖鎖結合TNFαの作用機構の解析Principal Investigator
- Principal Investigator
  
  小野嵜菊夫
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya City University
Molecular mechanism of CHOP dependent cell death induced by extracellular stresses
- Principal Investigator
  
  HAYASHI Hidetoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagoya City University
内分泌攪乱物質による免疫応答の攪乱撹乱作用
- Principal Investigator
  
  林秀敏
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Nagoya City University
Study on the action mechanism of IL-1 and its regulationPrincipal Investigator
- Principal Investigator
  
  ONOZAKI Kikuo
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagoya City University
Regulation of signal transduction through toll like receptors (interleukin-1 receptor related) by stimulation of live Mycobacterium tuberculosis
- Principal Investigator
  
  TAKII Takemasa
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  Nagoya City University
BCGワクチン、結核菌毒力の新しい評価法の開発Principal Investigator
- Principal Investigator
  
  小野嵜菊夫
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagoya City University
Control of TGFβ signaling by degradation of Smads, TGFβ signal transducers
- Principal Investigator
  
  HAYASHI Hidetoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagoya City University
腫瘍細胞におけるインターロイキン1の作用発現制御に関する研究Principal Investigator
- Principal Investigator
  
  小野嵜菊夫
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagoya City University
担癌状態におけるTGFβを介した免疫抑制作用の基礎的研究
- Principal Investigator
  
  林秀敏
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Nagoya City University
The mechanism and its regulation of interleukin 1 biological activitiesPrincipal Investigator
- Principal Investigator
  
  ONOZAKI Kikuo
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Faculty of Pharmaceutical Sciences, Nagoya City University
Study on interleukin 1 signal transductionPrincipal Investigator
- Principal Investigator
  
  ONOZAKI Kikuo
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Faculty of Pharmaceutical Sciences, Nagoya City University
Development of IL-1 with selective activities by introduction of carbohydratesPrincipal Investigator
- Principal Investigator
  
  ONOZAKI Kikuo
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Faculty of Pharmaceutical Sciences, Nagoya City University
インターロイキン1の構成的産生ヒトメラノーマ細胞の癌原性及び転移能に関する研究
- Principal Investigator
  
  HAYASHI Hidetoshi
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Nagoya City University
Study on the interleukin-1 signalingPrincipal Investigator
- Principal Investigator
  
  ONOZAKI Kikuo
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagoya City University
The mechanism of the acquired resistance to the anti-proliferative effect of IL-1 on human melanoma cells.Principal Investigator
- Principal Investigator
  
  ONOZAKI Kikuo
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagoya City University
Study on the IL-1-Mediated Signal Transduction System
- Principal Investigator
  
  KASAHARO Tadashi
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Jichi Medical School
Study on the Interleukin 1 Growth-Regulatory Activity.Principal Investigator
- Principal Investigator
  
  ONOZAKI Kikuo
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Fac of Pharmaceutical Sciences, Nagoya City University
精製ヒト・インターロイキン1の制癌への応用の試み
- Principal Investigator
  
  橋本逹一郎
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  University of Tsukuba

All 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2000

All Journal Article Presentation Patent

[Journal Article] Interleukin 1(IL-1) alpha, beta, IL-1受容体とIL-1受容体アンタゴニスト2011
- Author(s)
  林秀敏、小野嵜菊夫
- Journal Title
  
  日本臨床
  
  Volume: 68 Pages: 662-66
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Etiological role of cigarette smoking in rheumatoid arthritis : Nasal exposure to cigarette smoke condensate extracts augments the development of collagen-induced arthritis in mice.2011
- Author(s)
  Okamoto S, Adachi M, Chujo S, Yamada K, Akita K, Itoh S, Takii T, Hayakawa K, Onozaki K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 404(4) Pages: 1088-92
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Etiological role of cigarette smoking in rheumatoid arthritis : Nasal exposure to cigarette smoke condensate extracts augments the development of collagen-induced arthritis in mice.2011
- Author(s)
  Okamoto S, Adachi M, Chujo S, Yamada K, Akita K, Itoh S, Takii T, Hayakawa K, Onozaki K.
- Journal Title
  
  Biochem Biophys Res Commun. 404(4)
  
  Pages: 1088-1092
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives.2011
- Author(s)
  Horita Y, Takii T, Kuroishi R, Chiba T, Ogawa K, Kremer L, Sato Y, Lee Y, Hasegawa T, Onozaki K.
- Journal Title
  
  Bioorg Med Chem Lett. 21(3)
  
  Pages: 899-903
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Staphylococcal superantigen-like protein 10 (SSL10) binds to human immune-Globulin G(IgG) and inhibits complement activation via the classical pathway.2010
- Author(s)
  Itoh S, Hamada E, Kamoshida G, Yokoyama R, Takii T, Onozaki K, Tsuji T.
- Journal Title
  
  Mol Immunol. 47(4)
  
  Pages: 932-938
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Staphylococcal superantigen-like protein 10 (SSL10) binds to human immunoglobulin G (IgG) and inhibits complement activation via the classical pathway.2010
- Author(s)
  Itoh S, Hamada E, Kamoshida G, Yokoyama R, Takii T, Onozaki K, Tsuji T.
- Journal Title
  
  Mol Immunol. 47(4)
  
  Pages: 932-8
- Data Source
  KAKENHI-PROJECT-19590122
[Journal Article] Anaphase-promoting complex/cyclosomecdh 1 mediates the ubiquitination and degradation of TRB3.2010
- Author(s)
  Ohoka N, Sakai S, Onozaki K, Nakanishi M, Hayashi H.
- Journal Title
  
  Biochem Biophys Res Commun. 92(3)
  
  Pages: 289-294
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Biochemical characteristics among Mycobacterium bovis BCG substrains.2010
- Author(s)
  Hayashi D, Takii T, Mukai T, Makino M, Yasuda E, Horita Y, Yamamoto R, Fujiwara A, Kanai K, Kondo M, Kawarazaki A, Yano I, Yamamoto S, Onozaki K
- Journal Title
  
  FEMS Microbiol Lett. 306(2)
  
  Pages: 103-109
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] IL-1-induced ERK1/2 activation up-regulates p21(Waf1/Cip1) protein by inhibition of degradation via ubiquitin-independent pathway in human melanoma cells A375.2010
- Author(s)
  Arakawa T, Hayashi H, Itoh S, Takii T, Onozaki K
- Journal Title
  
  Biochem Biophys Res Commun. 392(3)
  
  Pages: 369-372
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3.2010
- Author(s)
  Ohoka N, Sakai S, Onozaki K, Nakanishi M, Hayashi H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 392(3) Pages: 289-294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Dual mode of regulation of cell division cycle 25 A protein by TRB3.2010
- Author(s)
  Sakai S, Ohoka N, Onozaki K, Kitagawa M, Nakanishi M, Hayashi H.
- Journal Title
  
  Biol Pharm Bull. 33(7)
  
  Pages: 1112-1116
- NAID
  130000300272
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Dual mode of regulation of cell division cycle 25 A protein by TRB3.2010
- Author(s)
  Sakai S, Ohoka N, Onozaki K, Kitagawa M, Nakanishi M, Hayashi H.
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 33(7) Pages: 1112-6
- NAID
  130000300272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Cigarette smoke condensate extracts augment collagen-induced arthritis in mice.2010
- Author(s)
  Chujo S, Okamoto S, Sunahara R, Adachi M, Yamada K, Hayashi H, Taakii T, Hayakawa K, Onozaki K
- Journal Title
  
  Int Immunopharmacol. 10(10)
  
  Pages: 1194-1199
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Halophilic beta-lactama as a new solubility-and folding-enhancing tag protein : production of native human interleukin 1 alpha and human neutrophil alpha-defensin.2010
- Author(s)
  Tokunaga H, Saito S, Sakai K, Yamaguchi R, Katsuyama I, Arakawa T, Onozaki K Arakawa T, Tokunaga M.
- Journal Title
  
  Appl Microbiol Biotechnol. 86(2)
  
  Pages: 649-658
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] IL-1-induced ERK1/2 activation up-regulates p21(Waf1/Cip1) protein by inhibition of degradation via ubiquitin-independent pathway in human melanoma cells A375.2010
- Author(s)
  Arakawa T, Hayashi H, Itoh S, Takii T, Onozaki K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 392(3) Pages: 369-372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] IL-1-induced ERK1/2 activation up-regulates p21(Waf1/Cip1) protein by inhibition of degradation via ubiquitin-independent pathway in human melanoma cells A375.2010
- Author(s)
  Arakawa T, Hayashi H, Itoh S, Takii T, Onozaki K.
- Journal Title
  
  Biochem Biophys Res Commun. 392(3)
  
  Pages: 369-72
- Data Source
  KAKENHI-PROJECT-19590122
[Journal Article] Staphylococcal superantigen-like protein 10(SSL10) binds to human immunoglobulin G(IgG) and inhibits complement activation via the classical pathway.2010
- Author(s)
  Itoh S, Hamada E, Kamoshida G, Yokoyama R, Takii T, Onozaki K, Tsuji T.
- Journal Title
  
  Mol Immunol.
  
  Volume: 47(4) Pages: 932-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Effectiveness of BCG vaccination to aged mice2010
- Author(s)
  Ito T, Takii T, Mitsuo Maruyama M, Daisuke Hayashi D, Takeshi Wako T, Azusa Asai A, Yasuhiro, Horita Y, Taniguchi K, Yano I, Yamamoto S, Onozaki K
- Journal Title
  
  Immunity & Ageing 7
  
  Pages: 12-15
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] An environmental sensor, TRPV4 is a novel regulator of intracellular Ca^<2+> in human, synoviocytes.2009
- Author(s)
  Itoh Y, Hatano N, Hayashi H, Onozaki K, Miyazawa K, Muraki K.
- Journal Title
  
  Am J Physiol Cell Physiol. 297(5)
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis2009
- Author(s)
  Horita Y, Takii T, Chiba T, Kuroishi R, Maeda Y, Kurono Y, Inagaki E, Nishimura K, Yamamoto Y, Abe C, Mori M, Onozaki K.
- Journal Title
  
  Bioorg Med Chem Lett. 19(22)
  
  Pages: 6313-6316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590122
[Journal Article] Population is a Critical Factor for Global Carbon Dioxide Increase2009
- Author(s)
  Onozaki K
- Journal Title
  
  J Health Sci 55(1)
  
  Pages: 125-127
- NAID
  110007055902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Population is a Critical Factor for Global Carbon Dioxide Increase.2009
- Author(s)
  Onozaki K
- Journal Title
  
  J. Health Sci. 55(1)
  
  Pages: 125-127
- NAID
  110007055902
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Staphylococcal superantigen-like protein 10(SSL10)binds to human immunoglobulin G(IgG)and inhibits complement activation via the classical pathway2009
- Author(s)
  Itoh S, Hamada E, Kamoshida G, Yokoyama R, Takii T, Onozaki K, Tsuji T
- Journal Title
  
  Mol Immunol 74(4)
  
  Pages: 932-938
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis.2009
- Author(s)
  Horita Y, Takii T, Chiba T, Kuroishi R, Maeda Y, Kurono Y, Inagaki E, Nishimura K, Yamamoto Y, Abe C, Mori M, Onozaki K.
- Journal Title
  
  Bioorg Med Chem Lett. 19(22)
  
  Pages: 6313-6
- Data Source
  KAKENHI-PROJECT-19590122
[Journal Article] Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Guerin(BCG)substrains2009
- Author(s)
  Hayashi D, Takii T, Fujiwara N, Fujita Y, Yano I, Yamamoto S, Kondo M, Yasuda E, Inagaki E, Kanai K, Fujiwara A, Kawarazaki A, Chiba T, Onozaki K.
- Journal Title
  
  FEMS Immunol Med Microbiol. 56(2)
  
  Pages: 116-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590122
[Journal Article] An environmental sensor, TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes2009
- Author(s)
  Itoh Y, Hatano N, Hayashi H, Onozaki K, Miyazawa K, Muraki K.
- Journal Title
  
  Am J Physiol Cell Physiol 297(5)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis2009
- Author(s)
  Horita Y, Takii T, Chiba T, Kuroishi R, Maeda Y, Kurono Y, Inagaki E, Nishimura K, Yamamoto Y, Abe C, Mori M, Onozaki K.
- Journal Title
  
  Bioorg Med Chem Lett. 15;19(22)
  
  Pages: 6313-6316
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Guerin (BCG) substrains.2009
- Author(s)
  Hayashi D, Takii T, Fujiwara N, Fujita Y, Yano I, Yamamoto S, Kondo M, Yasuda E, Inagaki E, Kanai K, Fujiwara A, Kawarazaki A, Chiba T, Onozaki K.
- Journal Title
  
  FEMS Immunol Med Microbiol. 56(2)
  
  Pages: 116-128
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB32009
- Author(s)
  Ohoka N, Sakai S, Onozaki K, Nakanishi M, Hayashi H
- Journal Title
  
  Biochem Biophys Res Commun 392(3)
  
  Pages: 289-294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Etiological and biological aspects of cigarette smoking in rheumatoid arthritis.2009
- Author(s)
  Onozaki K.
- Journal Title
  
  Inflamm Allergy Drug Targets. 8(5)
  
  Pages: 364-368
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] IL-1-induced ERK1/2 activation up-regulates p21(Wafl/Cip1)protein by inhibition of degradation via ubiquitin-independent pathway in human melanoma cells A3752009
- Author(s)
  Arakawa T, Hayashi H, Itoh S, Takii T, Onozaki K
- Journal Title
  
  Biochem Biophys Res Commun 392(3)
  
  Pages: 369-372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Guerin (BCG) substrains.2009
- Author(s)
  Hayashi D, Takii T, Fujiwara N, Fujita Y, Yano I, Yamamoto S, Kondo M, Yasuda E, Inagaki E, Kanai K, Fujiwara A, Kawarazaki A, Chiba T, Onozaki K.
- Journal Title
  
  FEMS Immunol Med Microbiol. 56(2)
  
  Pages: 116-28
- Data Source
  KAKENHI-PROJECT-19590122
[Journal Article] Etiological and biological aspects of cigarette smoking in rheumatoid arthritis2009
- Author(s)
  Onozaki K
- Journal Title
  
  Inflamm Allergy Drug Targets 8(5)
  
  Pages: 364-368
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Cigarette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line.2008
- Author(s)
  Shizu M, Itoh Y, Sunahara R, Chujo S, Hayashi H, Ide Y, Takii T, Koshiko M, Chung SW, Hayakawa K, Miyazawa K, Hirose K. Onozaki K
- Journal Title
  
  Journal of Interferon Cytokine Research 28・8
  
  Pages: 509-521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590122
[Journal Article] Contribution of extracellular signal-regulated kinases to the IL-1-induced growth inhibition of human melanoma cells A375.2008
- Author(s)
  T. Arakawa, T. Yamamura, T. Hattori, H. Hayashi, A. Mori, A. Yoshida, C. Uchida, M. Kitagawa, K. Onozaki
- Journal Title
  
  Int Immunopharmacol. 8(1)
  
  Pages: 80-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Cigarette smoke condensate up-regulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line.2008
- Author(s)
  Shizu M, Itoh Y, Sunahara R, Chujo S, Hayashi H, Ide Y, Takii T, Koshiko M, Chung SW, Hayakawa K, Miyazawa K, Hirose K, Onozaki K.
- Journal Title
  
  J.Interferon Cytokine Res. 28
  
  Pages: 509-522
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] The interaction with Spl and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1 alpha in human melanoma cells.2008
- Author(s)
  Enya K, Hayashi H, Takii T, Ohoka N, Kanata S, Okamoto T, Onozaki K.
- Journal Title
  
  J. Leukoc. Biol. 83・1
  
  Pages: 190-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590122
[Journal Article] The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1 alpha in human melanoma cells.2008
- Author(s)
  Enya K, Hayashi H, Takii T, Ohoka N, Kanata S, Okamoto T, Onozaki K.
- Journal Title
  
  J Leukoc Biol. 83(1)
  
  Pages: 190-9
- Data Source
  KAKENHI-PROJECT-19590122
[Journal Article] Inhibition of Human Immunodeficiency Virus Type 1 Replication by Blocking I{kappa}B Kinase with Noraristeromycin.2008
- Author(s)
  Asamitsu K, Yamaguchi T, Nakata K, Hibi Y, Victoriano AF, Imai K, Onozaki K, Kitade Y, Okamoto T.
- Journal Title
  
  J.Biochem. 144(5)
  
  Pages: 581-589
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1α in human melanoma cells.2008
- Author(s)
  Enya K, Hayashi H, Takii T, Ohoka N, Kanata S, Okamoto T, Onozaki K.
- Journal Title
  
  J.Leuk.Biol. 83(1)
  
  Pages: 190-199
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] The interaction with Spl and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1 alpha in human melanoma cells2008
- Author(s)
  Enya K, Hayashi H, Takii T, Ohoka N, Kanata S, Okamoto T, Onozaki K.
- Journal Title
  
  Journal of Leukocyte Biology 83・1
  
  Pages: 190-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590122
[Journal Article] Cigarette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line.2008
- Author(s)
  Shizu M, Itoh Y, Sunahara R, Chujo S, Hayashi H, Ide Y, Takii T, Koshiko M, Chung SW, Hayakawa K, Miyazawa K, Hirose K, Onozaki K.
- Journal Title
  
  J Interferon Cytokine Res. 28(8)
  
  Pages: 509-21
- Data Source
  KAKENHI-PROJECT-19590122
[Journal Article] Contribution of extracellular signal-regulated kinases to the IL-1-induced growth inhibition of human melanoma cells A375.2008
- Author(s)
  Arakawa T, Yamamura T, Hattori T, Hayashi H, Mori A, Yoshida A, Uchida C, Kitagawa M, Onozaki K.
- Journal Title
  
  Int Immunopharmacol. 8(1)
  
  Pages: 80-89
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] The interaction with Spl and reduction in the activity of histone deacetylase l are critical for the constitutive gene expression of IL-1α in human melanoma cells.2008
- Author(s)
  K. Enya, H. Hayashi, T. Takii, N. Ohoka, S. Kanata, T. Okamoto, K. Onozaki
- Journal Title
  
  J. Leuk. Biol. 83(1)
  
  Pages: 190-199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590064
[Journal Article] Synthesis of new sugar derivatives from Stachys sieboldi Miq and antibacterial evaluation against Mycobacterium tuberculosis, Mycobacterium avium, and Staphylococcus aureus.2007
- Author(s)
  Chiba T, Takii T, Nishimura K, Yamamoto Y, Morikawa H, Abe C, K. Onozaki
- Journal Title
  
  Bioorg Med Chem Lett. 17
  
  Pages: 2487-2491
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590105
[Journal Article] Synthesis of glycosylated human tumor necrosis factor a coupled with N-acetylneuramnic acid.2007
- Author(s)
  A.Hayashi, T.Chiba, H.Hayashi, S.Sasayama, T.Ishiguro, K.Onozaki
- Journal Title
  
  Cancer Immuno. Immunother. 56・4
  
  Pages: 545-553
- Data Source
  KAKENHI-PROJECT-17659037
[Journal Article] Dihydroteststerone inhibits tumor necrosis factor alpha induced interleukin-l alpha mRNA expression in rheumatoid fibroblast-like synovial cells.2007
- Author(s)
  Itoh, Y., Hayashi, H., Xu, J., Takii, T., Miyazawa, K., Ariga, H., Akahoshi, T., Waguri-Nagaya, Y., Otsuka, T., Okamoto T., K.Onozaki
- Journal Title
  
  Biol. Pharm. Bull. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590105
[Journal Article] Symthesis of new sugar derivatives from Stachys sieboldi Miq and antibacterial evaluation against Mycobacteriu tuberculosis, Mycobacterium avium, and Staphylococcus aureus.2007
- Author(s)
  Chiba T, Takai T, Nishimura K, Yamamoto Y, Morikawa H, Abe C, Onozaki K
- Journal Title
  
  Bioorg Med Chem Lett. 17・9
  
  Pages: 2487-2791
- Data Source
  KAKENHI-PROJECT-17590105
[Journal Article] Synthesis of new sugar derivatives from Stachys sieboldi Miq and antibacterial evaluation against Mycobacterium tuberculosis, Mycobacterium avium, and Staphylococcus aureus.2007
- Author(s)
  Chiba T, Teki T, Nishimura K, Yamamoto Y, Morikawa H, Abe C, K. Onozaki
- Journal Title
  
  Bioorg Med Chem Lett. 17(9)
  
  Pages: 2487-2491
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590105
[Journal Article] Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cells.2007
- Author(s)
  Itoh Y, Hayashi H, Xu J, Takii T, Miyazawa K, Ariga H, Akahoshi T, Waguri-Nagaya Y, Otsuka T, Okamoto T, Onozaki K.
- Journal Title
  
  Biol Pharm Bull. 30(6)
  
  Pages: 1140-3
- NAID
  120005350115
- Data Source
  KAKENHI-PROJECT-19590122
[Journal Article] Synthesis of new sugar derivatives from Stachys sieboldi Miq and antibacterial evaluation against Mycobacterium tuberculosis, Mycobacterium avium, and Staphylococcus aureus.2007
- Author(s)
  Chiba T, Takii T, Nishimura K, Yamamoto Y, Morikawa H, Abe C, Onozaki K.
- Journal Title
  
  Bioorg Med Chem Lett. 17(9)
  
  Pages: 2487-91
- Data Source
  KAKENHI-PROJECT-19590122
[Journal Article] 17β-Estradiol Induces IL-1α Gene Expression in Rheumatoid Fibroblast-Like Synovial Cells through Estrogen Receptor α (ERα) and Augmentation of Transcriptional Activity of Sp1 by Dissociating Histone Deacetylase 2 from ERα.2007
- Author(s)
  Y.Itoh, H.Hayashi, K.Miyazawa, S.Kojima, T.Akahoshi, K.Onozaki
- Journal Title
  
  J.Immunol. 178・5
  
  Pages: 3059-3066
- Data Source
  KAKENHI-PROJECT-17659037
[Journal Article] Study of susceptibility to nitric oxide among Mycobacterium bovis BCG strains and analysis of inducing activity of nitric oxide.2007
- Author(s)
  Teki, T., Konodo, M., Kanai, K., Fujiwara, A., Yamamoto, S., Onozaki, K.
- Journal Title
  
  BCG・BRM-ryoho-kennkyuukai-kaishi 29
  
  Pages: 3-8
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590105
[Journal Article] Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-lalphamRNA expression in rheumatoid fibroblast-like synovial cells.2007
- Author(s)
  Itoh Y, Hayashi H, Xu J, Takii T, Miyazawa K, Ariga H, Akahoshi T, Waguri-Nagaya Y, Otsuka T, Okamoto T, Onozaki K.
- Journal Title
  
  Biol. Pharm. Bull. 30・6
  
  Pages: 1140-1143
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590122
[Journal Article] Synthesis of new sugar derivatives from Stachys sieboldi Miq and antibacterial evaluation against Mycobacterium tuberculosis, Mycobacterium avium, and Staphylococcus aureus.2007
- Author(s)
  Chiba T, Takii T, Nishimura K, Yamamoto Y, Morikawa H, Abe C, Onozaki K.
- Journal Title
  
  Bioorg Med Chem Lett. 17・9
  
  Pages: 2487-2791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590122
[Journal Article] N-acetylneuraminic acid coupled human recombinant TNFa exhibits enhanced anti-tumor activity against Meth-A fibrosarcoma and reduced toxicity.2007
- Author(s)
  A.Hayashi, H.Hayashi, T.Chiba, S.Sasayama, K.Onozaki
- Journal Title
  
  Cancer Immuno.Immunother. 56・4
  
  Pages: 555-562
- Data Source
  KAKENHI-PROJECT-17659037
[Journal Article] Dihydroteststerone inhibits tumor necrosis factor alpha induced interleukin-1 alpha mRNA expression in rheumatoid fibroblast-like synovial cells.2007
- Author(s)
  Itoh, Y., Hayashi, H., Xu, J., Takii, T., Miyazawa, K., Ariga, H., Akahoshi, T., Waguri-Nagaya, Y., Otsuka, T., Okamoto T., Onozaki K.
- Journal Title
  
  Biol. Pharm. Bull. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590105
[Journal Article] Mycobacterium bovis BCG亜株間の一酸化窒素(NO)感受性とNO産生誘導能の差異に関する研究2006
- Author(s)
  瀧井猛将, 近藤真紀, 金井啓太, 藤原綾希子, 山本三郎, 小野嵜菊夫
- Journal Title
  
  BCG・BRM療法研究会会誌 (In Press)
- Data Source
  KAKENHI-PROJECT-17590105
[Journal Article] Estrogen Stimulates Transcription of Human Immunodeficiency Virus Type 1 (HIV-1)2006
- Author(s)
  D.Katagiri, H.Hayashi, A.F.B.Victoriano, T.Okamoto, K.Onozaki
- Journal Title
  
  Int.Immunopharmacol 8(2)
  
  Pages: 171-181
- Data Source
  KAKENHI-PROJECT-17659037
[Journal Article] CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation.2006
- Author(s)
  K.Shirakawa, S.Maeda, T.Gotoh, M.Hayashi, K.Shinomiya, S.Ehata, R.Nishimura, M.Mori, K.Onozaki, H.Hayashi, S.Uematsu, S.Akira, E.Ogata, K.Miyazono, T.Imamura
- Journal Title
  
  Mol.Cell Biol. 26・16
  
  Pages: 6105-6116
- Data Source
  KAKENHI-PROJECT-17659037
[Journal Article] Smad3 is acetylated by p300/CBP to regulate its transactivation activity.2006
- Author(s)
  Y.Inoue, Y.Itoh, K.Abe, T.Okamoto, H.Daitoku, A.Fukamizu, K.Onozaki, H.Hayashi
- Journal Title
  
  Oncogene 5・64
  
  Pages: 235-237
- Data Source
  KAKENHI-PROJECT-17659037
[Journal Article] Estrogen stimulates transcription of human immunodeficiency virus type 1 (HIV-1).2006
- Author(s)
  D.Katagiri, H.Hayashi, A.F.B, Victoriano, T.Okamoto, K.Onozaki
- Journal Title
  
  International Immunopharmacology 6(1)
  
  Pages: 170-181
- Data Source
  KAKENHI-PROJECT-16590057
[Journal Article] Estrogen Stimulates Transcription of Human Immunodeficiency Virus Type 1 (HIV-1)2006
- Author(s)
  D.Katagiri, H.Hayashi, A.F.B.Victoriano, T.Okamoto, K.Onozaki
- Journal Title
  
  Int.Immunopharmacol 8・2
  
  Pages: 171-181
- Data Source
  KAKENHI-PROJECT-17659037
[Journal Article] Simple fibroblast-based assay to test the pyrazinamide susceptibility to Mycobacterium tuberculosis.2005
- Author(s)
  Takii, T., Hamasaki, S., Hirano., K.Abe, C., K.Onozaki
- Journal Title
  
  Antimicrobial Agents and Chemotherapy 49・2
  
  Pages: 804-807
- Data Source
  KAKENHI-PROJECT-17590105
[Journal Article] Mycobacterium bovis BCG亜株間の一酸化窒素(NO)感受性とNO産生誘導能の差異に関する研究2005
- Author(s)
  瀧井猛将, 近藤真紀, 金井啓太, 藤原綾希子, 山本三郎, 小野嵜菊夫
- Journal Title
  
  BCG ・ BRM療法研究会会誌 29
  
  Pages: 3-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590105
[Journal Article] TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.2005
- Author(s)
  N.Ohoka, S.Yoshii, T.Hattori, K.Onozaki, H.Hayashi
- Journal Title
  
  EMBO J. 26(4)
  
  Pages: 1243-1255
- Data Source
  KAKENHI-PROJECT-17659037
[Journal Article] TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOF pathway and involved in cell death.2005
- Author(s)
  N.Ohoka, S.Yoshii, T.Hattori, K.Onozaki, H.Hayashi
- Journal Title
  
  EMBO Journal 24(6)
  
  Pages: 1243-1255
- Data Source
  KAKENHI-PROJECT-16590057
[Journal Article] Pyrazinamic acid susceptibility test of Mycobacterium tuberculosis by simple fibroblast assay2005
- Author(s)
  Takii.T., Hamasaki, S., Hirano, K., Abe, C., K.Onozaki
- Journal Title
  
  Antimicrob. Agents Chemother. 49(2)
  
  Pages: 804-807
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572111
[Journal Article] Interleukin 1(IL-1)alpha, beta, IL-1受容体とIL-1受容体アンタゴニスト2005
- Author(s)
  林秀敏, 小野嵜菊夫
- Journal Title
  
  日本臨床 63
  
  Pages: 60-64
- Data Source
  KAKENHI-PROJECT-17659037
[Journal Article] Simple fibroblast-based assay to test the pyrazinamide susceptibility of Mycobacterium tuberculosis.2005
- Author(s)
  Takii T, Hamasaki S, Hirano K, Abe C, Onozaki K
- Journal Title
  
  Antimicrob Agents Chemother 49・2
  
  Pages: 804-807
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572111
[Journal Article] Simple fibroblast-based assay to test the pyrazinamide susceptibility of Mycobacterium tuberculosis.2005
- Author(s)
  Takii T, Hamasaki S, Hirano K, Abe C, Onozaki K.
- Journal Title
  
  Antimicrob Agents Chemother 49(2)
  
  Pages: 804-807
- Data Source
  KAKENHI-PROJECT-14572111
[Journal Article] Pyrazinamic acid susceptibility test of Mycobacterium tuberculosis by simple fibroblast assay.2005
- Author(s)
  T.Takii, S.Hamasaki, K.Hirano, C.Abe, K.Onozaki
- Journal Title
  
  Antimicrob.Agents Chemother. 49(2)
  
  Pages: 804-807
- Data Source
  KAKENHI-PROJECT-17659037
[Journal Article] TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and involved in cell death.2005
- Author(s)
  N.Ohoka, S.Yoshii, T.Hattori, K.Onozaki, H.Hayashi
- Journal Title
  
  EMBO Journal (in press)
- Data Source
  KAKENHI-PROJECT-16590057
[Journal Article] TGF-beta down-regulates IL-1alpha-induced TLR2 expression in murine hepatocytes.2004
- Author(s)
  Matsumura T, Hayashi H, Takii T, Thorn CF, Whitehead AS, Inoue J, Onozaki K
- Journal Title
  
  J Leukocyto Biology 75・6
  
  Pages: 1056-1061
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572111
[Journal Article] TGFβ down-regulates IL-1α-induced functional TLR2 expression in murine hepatocytes.2004
- Author(s)
  T.Matsumura, H.Hayashi, T.Takii, C.F Thorn, A.S.Whitehead, J.Inoue, K.Onozaki
- Journal Title
  
  Journal of Leukocyte Biology 75・6
  
  Pages: 1056-1061
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] Polyaromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor2004
- Author(s)
  Ayako Tyamaki, Hidetoshi Hayashi, Hironori Nakajima, Takemasa Takii, Daichi Katagiri, Keiji Miyzazawa, Kunitaka Hirose, Kikuo Onozaki
- Journal Title
  
  Biol. Pharm. Bull. 27(3)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] Contribution of the constitutive and inducible degradation of Smad3 by the ubiquitin-proteasome.2004
- Author(s)
  Y.Inoue, M.Kitagawa, K.Onozaki, Hayashi
- Journal Title
  
  Journal of Interferon and Cytokine Research 24・1
  
  Pages: 43-54
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] Polyaromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor.2004
- Author(s)
  A.Tamaki, H.Hayashi, H.Nakajima, T.Takii, D.Katagiri, K.Miyazawa, K.Hirose, K.Onozaki
- Journal Title
  
  Biology and Pharmaceutical Bulletin 27・3
  
  Pages: 407-410
- Data Source
  KAKENHI-PROJECT-16023260
[Journal Article] TGFβ down-regulates IL-1α-induced functional TLR2 expression in murine hepatocytes.2004
- Author(s)
  T.Matsumura, H.Hayashi, T.Takii, C.F.Thorn, A.S.Whitehead, J.Inoue, K.Onozaki
- Journal Title
  
  Journal of Leukocyt Biology 75・6
  
  Pages: 1056-1061
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] TGF-β down-regulates IL-1α-induced TLR2 expression in murine hepatocytes2004
- Author(s)
  Matsumura, T., Hayashi, H., Takii, T., Thom, C.F., Whitehead, A.S., Inoue, J., K.Onozaki
- Journal Title
  
  J. Leuko. Biol. 75(6)
  
  Pages: 1056-1061
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572111
[Journal Article] Contribution of the constitutive and inducible degradation of Smad3 by the ubiquitin-proteasome.2004
- Author(s)
  Y.Inoue, M.Kitagawa, K.Onozaki, H.Hayashi
- Journal Title
  
  Journal of Interferon and Cytokine Research 24・1
  
  Pages: 43-54
- Data Source
  KAKENHI-PROJECT-16023260
[Journal Article] Polyaromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor.2004
- Author(s)
  A.Tyamaki, H.Hayashi, H.Nakajima, T.Takii, D.Katagiri, K.Miyazawa, K.Hirose, K.Onozaki
- Journal Title
  
  Biology and Pharmaceutical Bulletin 27・3
  
  Pages: 407-410
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] Polyaromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor.2004
- Author(s)
  A.Tyamaki, H.Hayashi, H.Nakajima, T.Takii, D.Katagiri, K.Miyzazawa, K.Hirose, K.Onozaki
- Journal Title
  
  Biology and Pharmaceutical Bulletin 27・3
  
  Pages: 407-410
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] Synthesis and biological activities in vitro and in vivo of glycosylated human interleukin-1α.2004
- Author(s)
  M.Ootsubo, T.Chiba, Y.Kobayashi, H.Hayashi, A.Hayashi, K.Onozaki
- Journal Title
  
  Glycoconjugate Journal 20・2
  
  Pages: 119-131
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] TGF-beta down-regulates IL-1alpha-induced TLR2 expression in murine hepatocytes.2004
- Author(s)
  Matsumura T, Hayashi H, Takii T, Thorn CF, Whitehead AS, Inoue J, Onozaki K.
- Journal Title
  
  J Leukocyto Biology 75(6)
  
  Pages: 1056-1061
- Data Source
  KAKENHI-PROJECT-14572111
[Journal Article] Contribution of the constitutive and inducible degradation of Smad3 by ubiquitin-proteasome pathway to TGFβ signaling.2004
- Author(s)
  Y.Inoue, M.Kitagawa, K.Onozaki, H.Hayashi
- Journal Title
  
  Journal of Interferon and Cytokine Research 24(1)
  
  Pages: 43-54
- Data Source
  KAKENHI-PROJECT-16590057
[Journal Article] TGFβ down-regulates IL- Iα-induced functional TLR2 expression in murine hepatocytes2004
- Author(s)
  Takayuki Matsumura, Hidetoshi Hayashi, Takemasa Takii, Caroline F Thorn, Alexander S. Whitehead, Jun-ichiro Inoue, Kikuo Onozaki
- Journal Title
  
  J. Leuk. Biol. 75(6)
  
  Pages: 1056-1061
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] Contribution of the constitutive and inducible degradation of Smad3 by the ubiquitin-proteasome pathway to transforming growth factorβ signailing2004
- Author(s)
  Yasumichi Inoue, Masatoshi Kitagawa, Kikuo Onozaki, Hidetoshi Hayashi
- Journal Title
  
  J. Interferon Cytokine Res. 24
  
  Pages: 43-54
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] TGFβ down-regulates IL-1α-induced functional TLR2 expression in murine hepatocytes.2004
- Author(s)
  T.Matsumura, H.Hayashi, T.Takii, C.F Thorn, A.S.Whitehead, J.Inoue, K.Onozaki
- Journal Title
  
  Journal of Leukocyt Biology 75・6
  
  Pages: 1056-1061
- Data Source
  KAKENHI-PROJECT-16023260
[Journal Article] Synthesis and biological activities in vitro and in vivo of glycosylated human interleukin-1α.2004
- Author(s)
  M.Ootsubo, T.Chiba, Y.Kobayashi, H.Hayashi, A.Hayashi, K.Onozaki
- Journal Title
  
  Glycoconjugate Journal 20・2
  
  Pages: 119-131
- Data Source
  KAKENHI-PROJECT-16023260
[Journal Article] Synthesis and biological activities in vitro and in vivo of glycosylated human interleukin-la neoglyco IL-1α. coupled with N-acetylneuraminyl-galactose2004
- Author(s)
  Masaaki Ootsubo, Taku Chiba, Yutaka Kobayashi, Hidetoshi Hayashi, Akiko Hayashi, Kikuo Onozaki
- Journal Title
  
  Glycoconjugate J. 20(2)
  
  Pages: 119-131
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] Polycyclic aromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor.2004
- Author(s)
  Tamaki A, Hayashi H, Nakajima H, Takii T, Katagiri D, Miyazawa K, Hirose K, Onozaki K
- Journal Title
  
  Biol Pharm Bull 27・3
  
  Pages: 407-410
- NAID
  110003608772
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572111
[Journal Article] Polycyclic aromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor2004
- Author(s)
  Tarnaki, A., Hayashi, H., Nakajima, H., Takii, T., Katagiri, D., Miyazawa, K., Hirose, K., K.Onozaki
- Journal Title
  
  Biol. Pharm. Bull. 27(3)
  
  Pages: 407-410
- NAID
  110003608772
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572111
[Journal Article] TRAF6-NF-kappaB pathway is essential for interleukin-1-induced TLR2 expression and its functional response to TLR2 ligand in murine hepatocytes.2003
- Author(s)
  Matsumura T, Degawa T, Takii T, Hayashi H, Okamoto T, Inoue J, Onozaki K
- Journal Title
  
  Immunology 109・1
  
  Pages: 127-136
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572111
[Journal Article] TRAF6-NF-kB Pathway is Essential for IL-1-induced TLR2 Expression and Its Functional Response to TLR2 Ligand in Murine Hepatocytes2003
- Author(s)
  Takayuki Matsumura, Takahiro Degawa, Takemasa Takii, Hidetoshi Hayashi, Takashi Okamoto, Jun-ichiro Inoue, Kikuo Onozaki
- Journal Title
  
  Immunology 109(1)
  
  Pages: 127-136
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL-6 isoform2003
- Author(s)
  Takayuki Hattori, Nobumichi Ohoka, Hidetoshi Hayashi, Kikuo Onozaki
- Journal Title
  
  FEBS Letters 541(1-3)
  
  Pages: 33-39
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer2003
- Author(s)
  Takayuki Hattori, Nobumichi Ohoka, Yasumichi Inoue, Hidetoshi Hayashi, Kikuo Onozaki
- Journal Title
  
  Oncogenes 22(9)
  
  Pages: 1273-1280
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] TGFβ down-regulates IFN-γ production in IL-18 treated NK cell line LNK5E62003
- Author(s)
  Hidetoshi Hayashi, Yasumichi Inoue, Hiroko Tsutsui, Haruki Okamura, Kenji Nakanishi, Kikuo Onozaki
- Journal Title
  
  Biochem. Biophys. Res. Commun. 300(4)
  
  Pages: 980-985
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] TRAF-6-NF-kB pathway is essential for IL-1-induced TLR2 expression and its functional response to TLR2 ligand in murine hepatocytes2003
- Author(s)
  Matsumura, T., Degawa, T., Takii, T., Hayashi, H., Okamoto, T., Inoue, J., K.Onozaki
- Journal Title
  
  Immunology 109(1)
  
  Pages: 127-136
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572111
[Journal Article] Multiple mechanisms involved in the inhibition of proinflammatory cytokine production2003
- Author(s)
  Takemasa Takii, Sachiko Kawashima, Taku Chiba, Hidetoshi Hayashi, Masaru Hayashi, Hiroyuki Hiroma, Hiroaki Kimura, Takashi Inukai, Yayoi Shibata, Akito Nagatsu, Jinsaku Sakakibara, Yasuo Oomoto, Kunitaka Hirose, Kikuo Onozaki
- Journal Title
  
  Int. Immunopharmacol. 3(2)
  
  Pages: 273-277
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] 3-Methylcholanthrene Activates Human Immunodeficiency Virus Type I Replication via Aryl Hydrocarbon Receptor2003
- Author(s)
  Hirokazu Ohata, Toshifumi Tetsuka, Hidetoshi Hayashi, Kikuo Onozaki, Takashi Okamoto
- Journal Title
  
  Microbilo. Immunol. 47(5)
  
  Pages: 363-370
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370750
[Journal Article] Multiple mechanisms involved in the inhibition of proinflammatory cytokine production from human monocytes by N-(p-coumaroyl)serotonin and its derivatives.2003
- Author(s)
  Takii T, Kawashima S, Chiba T, Hayashi H, Hayashi M, Hiroma H, Kimura H, Inukai Y, Shibata Y, Nagatsu A, Sakakibara J, Oomoto Y, Hirose K, Onozaki K
- Journal Title
  
  Int Immunopharmacol 3・2
  
  Pages: 273-277
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572111
[Journal Article] Multiple mechanisms involved in the inhibition of proinflammatory cytokine production from human monocytes by N (p-coumaroyl)serotonin and its derivatives2003
- Author(s)
  Takii, T., Kawashima, S., Chiba, T., Hayashi, H., Hayashi, M., Hiroma, H., Kimura, H., Inukai, Y., Shibata, Y., Nagatsu, A., Sakakibara, J., Oomoto, Y., Hirose, K., K.Onozaki
- Journal Title
  
  Inter. Immunopharmacology 3(2)
  
  Pages: 273-277
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572111
[Journal Article] Simple fibroblast-based assay for screening of new antimicrobial drugs against Mycobacterium tuberculosis2002
- Author(s)
  Takii T, Yamamoto Y, Chiba T, Abe C, Belisle JT, Brennan PJ, Onozaki K
- Journal Title
  
  Antimicrob Agents Chemother 46・8
  
  Pages: 2533-2539
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14572111
[Journal Article] Simple fibroblast-based assay for screening of new antimicrobial drugs against Mycobacterium tuberculosis2002
- Author(s)
  Takii, T., Yamamoto, Y., Chiba, T., Abe, C., Belisle, J.T., Brennan, P.J., K.Onozaki
- Journal Title
  
  Antimicrob. Agents Chemother 46(8)
  
  Pages: 2533-2539
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14572111
[Journal Article] Contribution of the constitutive and inducible degradation of Smad3 by the ubiquitin-proteasome.2000
- Author(s)
  Y.Inoue, M.Kitagawa, K.Onozaki, H.Hayashi
- Journal Title
  
  Journal of Interferon and Cytokine Research 24・1
  
  Pages: 43-54
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370750
[Patent] 抗結核薬及びその用途2009
- Inventor(s)
  瀧井猛将, 堀田康弘, 稲垣衣美, 小野嵜菊夫
- Industrial Property Rights Holder
  名古屋市立大学
- Industrial Property Number
  2009-021026
- Filing Date
  2009-01-31
- Data Source
  KAKENHI-PROJECT-19590122
[Patent] 抗結核化合物及びその用途2009
- Inventor(s)
  瀧井猛将, 堀田康弘, 稲垣衣美, 小野嵜菊夫
- Industrial Property Rights Holder
  名古屋市立大学
- Industrial Property Number
  2009-021026
- Filing Date
  2009-01-31
- Data Source
  KAKENHI-PROJECT-19590122
[Patent] 抗結核化合物及びその利用2008
- Inventor(s)
  瀧井猛将, 堀田康弘, 小野嵜菊夫, 千葉拓, 森雅美
- Industrial Property Rights Holder
  名古屋市立大学
- Industrial Property Number
  2008-059903
- Filing Date
  2008-03-10
- Data Source
  KAKENHI-PROJECT-19590122
[Presentation] Mycobacterium bovis BCGの免疫持続に関する研究2011
- Author(s)
  谷口恵一, 瀧井猛将, 林大介, 丸山光生, 小野嵜菊夫
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] 2-acetamide-2-deoxy-β-D-glucopyranosylN,N-dimethyldithiocarbamate(OCT313)の抗結核作用についての検討2011
- Author(s)
  長谷川倫宏, 瀧井猛将, 堀田康弘, 千葉拓, 黒石隆司, 小野嵜菊夫
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] 黄色ブドウ球菌分泌タンパク質SSL6はficolin-βに結合する2011
- Author(s)
  横山領介, 伊藤佐生智, 鴨志田剛, 瀧井猛将, 辻勉, 小野嵜菊夫
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] マウス関節炎の発症増強作用を示すタバコ成分に関する研究2011
- Author(s)
  秋田邦彦, 岡本翔佑, 中条里美, 足達実季, 山田恭平, 伊藤佐生智, 瀧井猛将, 早川和一, 小野嵜菊夫
- Organizer
  日本薬学会第131回年会 p253
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] タバコ抽出物によるマウス関節炎の増強作用2011
- Author(s)
  足達実季, 岡本翔佑, 中條里美, 山田恭平, 秋田邦彦, 伊藤佐生智, 瀧井猛将, 早川和一, 小野嵜菊夫
- Organizer
  日本薬学会第131回年会 p253
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] ジチオカルバメート誘導体の抗結核作用の機序についての検討2011
- Author(s)
  堀田康弘, 瀧井猛将, 千葉拓, 藤原永年, 小川賢二, 黒石隆司, 稲垣衣美, 小野嵜菊夫
- Organizer
  日本薬学会第131回年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-30
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] 男性ホルモンによる関節リウマチ滑膜細胞からの炎症性サイトカインの産生抑制2010
- Author(s)
  許鍵, 伊藤友香, 瀧井猛将, 林秀敏, 小野嵜菊夫
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-19590122
[Presentation] 男性ホルモンによる関節リウマチ滑膜細胞からの炎症性サイトカインの産生抑制 0P-pm0352010
- Author(s)
  許鍵, 伊藤友香, 瀧井猛将, 林秀敏, 小野嵜菊夫
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] 抗酒薬ジスルフィラムの抗結核作用についての検討2010
- Author(s)
  堀田康弘, 瀧井猛将, 小川賢二, 稲垣衣美, 小野嵜菊夫
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-19590122
[Presentation] トリ型結核菌亜種のアンモニア産生におけるArginine deiminaseの関与2010
- Author(s)
  山本龍二, 瀧井猛将, 堀田康弘, 小川賢二, 小野嵜菊夫
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-19590122
[Presentation] インターロイキン1によるヒトメラノーマ細胞増殖抑制機構の解析2010
- Author(s)
  荒川友博, 林秀敏, 伊藤佐生智, 瀧井猛将, 小野嵜菊夫
- Organizer
  フォーラム2010 衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] Rheumatoid arthritis patient-derived synoviocytes are more sensitive to cigarette smoke condensate extracts-induced IL-1 beta expression through NF-κB activation than OA patient-derived synoviocytes, human lung fibroblasts and human lung epithelial cells2010
- Author(s)
  K.Onozaki, S.Okamoto, M.Yokoyama, T.Arakawa, M.Adachi, K.Yamada, K.Akita, S.Itoh, T.Takii, Y.Wagur i-Nagaya, T.Otsuka, K.Hayakawa
- Organizer
  18th International Symposium on Molecular Cell Biology of Macrophages 2010
- Place of Presentation
  熊本
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] インターロイキン-1によるヒトメラノーマ細胞増殖抑制機構の解析2010
- Author(s)
  荒川友博, 林秀敏, 伊藤佐生智, 瀧井猛将, 小野嵜菊夫
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-28
- Data Source
  KAKENHI-PROJECT-19590122
[Presentation] Rheumatoid arthritis patient-derived synoviocytes are more sensitive to cigarette smoke condensate extracts-induced IL-1 beta mRNA expression through NF-・B activation than OA patient-derived synoviocytes2010
- Author(s)
  小野嵜菊夫, 岡本翔佑, 伊藤佐生智, 瀧井猛将
- Organizer
  human lung fibroblasts and human lung epithelial cells 14th International Congress of Immunology 2010 PP-036-13
- Place of Presentation
  Kobe, Japan
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] Staphylococcal superantigen-like protein 6 (SSL6)はブタフィコリンβに結合する2010
- Author(s)
  横山領介, 伊藤佐生智, 鴨志田剛, 瀧井猛将, 辻勉, 小野嵜菊夫
- Organizer
  第56回日本薬学会東海支部総会・大会
- Place of Presentation
  岐阜
- Year and Date
  2010-07-03
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] 黄色ブドウ球菌のスーパー抗原様タンパク質SSL10はヒトIgGに結合し古典経路による補体活性化を抑制する2010
- Author(s)
  伊藤佐生智, 濱田恵里, 鴨志田剛, 横山領介, 瀧井猛将, 小野嵜菊夫, 辻勉
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-19590122
[Presentation] タバコと関節リウマチに関する研究2010
- Author(s)
  足達実季, 岡本翔佑, 中條里美, 山田恭平, 秋田邦彦, 伊藤佐生智, 瀧井猛将, 早川和一, 小野嵜菊夫
- Organizer
  フォーラム2010 衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] タバコと関節リウマチに関する研究2010
- Author(s)
  岡本翔佑, 中條里美, 瀧井猛将, 林秀敏, 早川和一, 小野嵜菊夫
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-19590122
[Presentation] トリ型結核菌亜種のアンモニア産生におけるArginine deiminaseの関与2010
- Author(s)
  山本龍二、瀧井猛将、堀田康弘、小川賢二、小野嵜菊夫
- Organizer
  第9回次世代を担う若手ファーマ・バイオフォーラム2010
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] Staphylococcal superantigen-like protein 10 binds to human immunoglobulin G and inhibits the classical complement activation pathway2010
- Author(s)
  S.Itoh, E.Hamada, G.Kamoshida, T.Takii, K.Onozaki, T.Tsuji
- Organizer
  14th International Congress of Immunology 2010
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] Rheumatoid arthritis patient-derived synoviocytes are more sensitive to cigarette smoke condensate extracts-induced IL-1 beta mRNA expression through NF-κB activation than OA patient-derived synoviocytes, human lung fibroblasts and human lung epithelial cells2010
- Author(s)
  K.Onozaki, S.Okamoto, S.Itoh, T.Takii
- Organizer
  14th International Congress of Immunology 2010
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] BCG亜株の抗原提示能の差異およびBCGワクチンの有効性に関する研究2010
- Author(s)
  谷口恵一、瀧井猛将、林大介、矢野郁也、山本三郎、丸山光生、小野嵜菊夫
- Organizer
  第22回微生物シンポジウム
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] Mycobacterium bovis BCGの宿主細胞内生存能と抗原性の発現に関する研究2010
- Author(s)
  谷口恵一, 瀧井猛将, 安田恵実, 林大介, 向井徹, 山本三郎, 小野嵜菊夫
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-19590122
[Presentation] 黄色ブドウ球菌スーパー抗原様分泌タンパク質SSLファミリーによる補体活性化抑制作用2010
- Author(s)
  伊藤佐生智, 濱田恵里, 鴨志田剛, 横山領介, 瀧井猛将, 小野嵜菊夫, 辻勉
- Organizer
  フォーラム2010 衛生薬学・環境トキシコロジー
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] タバコと関節リウマチに関する研究2009
- Author(s)
  岡本翔佑, 中条里美, 瀧井猛将, 林秀敏, 早川和一, 小野嵜菊夫
- Organizer
  フォーラム2009:衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] 小胞体ストレス誘導性細胞死における pseudokinase TRB3の役割2009
- Author(s)
  中田佳宏, 酒井聡, 大岡伸通, 小野嵜菊夫, 林秀敏
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] Staphylococcal superantigen-like protein 5(SSL5)inhibits matrix metalloproteinase(MMP)-9 and impairs trafficking of neutrophils2009
- Author(s)
  伊藤佐生智, 横山領介, 辻勉, 瀧井猛将, 小野崎菊夫
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] Mycobacterium bovis BCG亜株の生化学的性状と宿主細胞内生存能の差異2009
- Author(s)
  林大介, 安田恵実, 瀧井猛将, 矢野郁也, 山本三郎, 小野嵜菊夫
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] Cigarette smoke condensate extracts induce proinflammatory cytokines from synovial cells and exacerbate collagen-induced arthritis in mice2009
- Author(s)
  小野嵜菊夫, 他7名
- Organizer
  Tri-Society Annual Conference 2009 of the Society for Leukocyte Biology, International Cytokine Society, & International Society for Interferon and Cytokine Research
- Place of Presentation
  Lisbon,(ポルトガル)
- Year and Date
  2009-11-21
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] 喫煙と関節リウマチ:たばこの煙抽出物は滑膜細胞から炎症性サイトカインの産生を誘導し、コラーゲン誘導性関節炎の発症を増強する2009
- Author(s)
  岡本翔佑, 林秀敏, 瀧井猛将, 小野嵜菊夫
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-19590122
[Presentation] ユビキチンリガーゼAPC/C Cdh1による pseudokinase TRB3の発現制御機構の解明2009
- Author(s)
  酒井聡, 大岡伸通, 北川雅敏, 中西真, 小野嵜菊夫, 林秀敏
- Organizer
  第82回日本生化学会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] 老齢マウスにおける結核症に対するBCG免疫能に関する研究2009
- Author(s)
  伊藤司, 林大介, 瀧井猛将, 丸山光生, 小野嵜菊夫
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] Cigarette smoking and rheumatoid arthritis : Cigarette smoke condensate extracts induce proinflammatory cytokines from synovial cells and exacerbate collagen-induced arthritis in mice2009
- Author(s)
  岡本翔佑, 林秀敏, 瀧井猛将, 小野嵜菊夫
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-12-04
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] 滑膜細胞における浸透圧センサーTRPV4のケモカイン産生に及ぼす影響2009
- Author(s)
  伊藤友香, 波多野紀行, 林秀敏, 小野嵜菊夫, 村木克彦
- Organizer
  フォーラム2009:衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] G2/M期でのストレス誘導性 pseudokinase TRB3の役割2009
- Author(s)
  酒井聡, 大岡伸通, 小野嵜菊夫, 中西真, 林秀敏
- Organizer
  フォーラム2009:衛生薬学・環境トキシコロジー
- Place of Presentation
  沖縄
- Year and Date
  2009-11-05
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] トリ型結核菌亜種の酸耐性メカニズムの差異に関する研究2009
- Author(s)
  山本龍二, 堀田康弘, 小川賢二, 小野嵜菊夫, 瀧井猛将
- Organizer
  第21回微生物シンポジウム
- Place of Presentation
  広島
- Year and Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] Cigarette smoke condensate extracts induce proinflammatory cytokines from synovial cells and exacerbate collagen-induced arthritis in mice Tri-Society Annual Conference 2009 of the Society for Leukocyte Biology2009
- Author(s)
  Onozaki K, Chujo S, Okamoto S, Sunahara R, Itoh Y, Hayashi H, Takii T, Hayakawa K
- Organizer
  International Cytokine Society, & International Society for Interferon and Cytokine Research
- Place of Presentation
  Lisbon
- Year and Date
  2009-11-21
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] 黄色ブドウ球菌スーパー抗原様タンパク質SSL5はMMP-9の活性を抑制し, 好中球の浸潤を阻害する2009
- Author(s)
  伊藤佐生智, 横山領介, 辻勉, 瀧井猛将, 小野崎菊夫
- Organizer
  第39回日本免疫学会総会・学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-04-12
- Data Source
  KAKENHI-PROJECT-19590122
[Presentation] 多剤耐性結核菌に有効な新規糖化合物の探索2009
- Author(s)
  堀田康弘, 瀧井猛将, 千葉拓, 黒石隆司, 小野嵜菊夫
- Organizer
  第8回次世代を担う若手ファーマ・バイオフォーラム2009
- Place of Presentation
  名古屋
- Year and Date
  2009-11-14
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] インターロイキン1によるヒトメラノーマ細胞増殖抑制機構へのERK1/2経路の関与2008
- Author(s)
  荒川友博, 林秀敏, 瀧井猛将, 小野嵜菊夫
- Organizer
  平成20年度日本薬学会東海支部例会
- Place of Presentation
  静岡
- Year and Date
  2008-12-06
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] ポリオウイルスベクターを用いた新規結核ワクチンの開発2008
- Author(s)
  D. Hayashi, T. Takii, T. Ito, M. Okada, K. Onozaki
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] インターロイキン1によるヒトメラノーマ細胞増殖抑制機構へのERK1/2経路の関与2008
- Author(s)
  荒川友博, 林秀敏, 瀧井猛将, 小野嵜菊夫
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-20590064
[Presentation] ストレス誘導性pseudokinase TRB3のT細胞分化に及ぼす影響2008
- Author(s)
  H. Hayashi, K. Onozaki
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-20590064

1. HAYASHI Hidetoshi (80198853)

# of Collaborated Projects: 15 results

# of Collaborated Products: 34 results
2. TAKII Takemasa (80244573)

# of Collaborated Projects: 13 results

# of Collaborated Products: 53 results
3. CHIBA Taku (10094385)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. KASAHARO Tadashi (60049096)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YAMAGUCHI Yuji (00220286)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YAGISAWA Hitoshi (40192380)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 橋本逹一郎 (90015975)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FURUTANI Taiji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KUWASHIMA Junji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Onozaki Kikuo 小野嵜 菊夫

ONOZAKI Kikuo 小野嵜 菊夫

小野崎 菊夫 オノザキ キクオ

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Regulatory mechanism of the induction and function of IL-1Principal Investigator

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関節リウマチと化学物質に関する研究Principal Investigator

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抗腫瘍活性の増強と毒性軽減を示す糖鎖結合TNFαの作用機構の解析Principal Investigator

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Study on the action mechanism of IL-1 and its regulationPrincipal Investigator

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BCGワクチン、結核菌毒力の新しい評価法の開発Principal Investigator

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腫瘍細胞におけるインターロイキン1の作用発現制御に関する研究Principal Investigator

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The mechanism and its regulation of interleukin 1 biological activitiesPrincipal Investigator

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Onozaki Kikuo 小野嵜菊夫

ONOZAKI Kikuo 小野嵜菊夫

小野崎菊夫オノザキキクオ