Hoshino Tsutomu 星野力

Researcher Number	20102709
Affiliation (based on the past Project Information) *help	2016: 新潟大学, 自然科学系, フェロー 2013 – 2015: 新潟大学, 自然科学系, 教授
Review Section/Research Field	Principal Investigator Bioorganic chemistry
Keywords	Principal Investigator トリテルペン / βーアミリン / オキシドスクアレン / 部位特異的変異実験 / 基質アナログ / 酵素反応 / ホペン / βアミリン

Research Projects
(1 results)
Research Products
(45 results)

Triterpene cyclases: catalytic mechanism and substrate recognition by evaluating activities and subsrate analogsPrincipal Investigator
- Principal Investigator
  
  Hoshino Tsutomu
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bioorganic chemistry
- Research Institution
  Niigata University

All 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 第2版マクマリー生物有機化学　基礎化学編2015
- Author(s)
  星野　力
- Total Pages
  382
- Publisher
  丸善株式会社
- Data Source
  KAKENHI-PROJECT-25450150
[Book] 第４版マクマリー生物有機化学～基礎化学編～2015
- Author(s)
  星野　力、青木　伸、秋澤宏行、生方　信、江頭　港、桑原重文、三田明弘、菅原二三男、堀内　要、轟　泰司、渡辺修治
- Publisher
  丸善出版
- Data Source
  KAKENHI-PROJECT-25450150
[Journal Article] βーAmyrin biosynthesis: catalytic mechanism and substrate recognition2017
- Author(s)
  T. Hoshino
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 15 Pages: 2869-2891
- DOI
  10.1039/c7ob00238f
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450150
[Journal Article] β-Amyrin Biosynthesis: Effect of Steric Bulk at the 6-, 10- and 15-Positions in the 2,3-Oxidosqualene Backbone on Polycyclisation Cascades2017
- Author(s)
  Y. Terasawa, Y. Sasaki, Y. Yamaguchi, K. Takahashi and T. Hoshino
- Journal Title
  
  European Journal of Organic Chemistry
  
  Volume: 2017 Pages: 287-295
- DOI
  10.1002/ejoc.201601306
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450150
[Journal Article] β-Amyrin synthase from Euphorbia tirucalli L. functional analyses of the highly conserved aromatic residues Phe413, Tyr259 and Trp257 disclose the importance of the appropriate steric bulk, and cation-π and CH-π interactions for the efficient catalytic action of the polyolefin cyclization cascade.2017
- Author(s)
  R. Ito, C. Nakada and T. Hoshino
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 15 Pages: 177-188
- DOI
  10.1039/c6ob02539k
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450150
[Journal Article] Further Insight into Polycyclization Cascades of Acyclic Geranylfarnesol and its Acetate by Squalene-hopene Cyclase from Alicyclobacillus acidocaldarius.2016
- Author(s)
  Cheng J, Nakano C, Shi GL, Hoshino T.
- Journal Title
  
  Natural Product Communications
  
  Volume: 11
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25450150
[Journal Article] β-Amyrin Biosynthesis: Promiscuity for Steric Bulk at Position 23 in the Oxidosqualene Substrate and the Significance of Hydrophobic Interaction between the Methyl Group at Position 30 and the Binding Site.2016
- Author(s)
  I. Kaneko and T. Hoshino
- Journal Title
  
  The Journal of Organic Chemistry
  
  Volume: 81 Pages: 6657-6671
- DOI
  10.1021/acs.joc.6b01313
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450150
[Journal Article] β-Amyrin Biosynthesis: The Methyl-30 Group of (3S)-2,3-Oxidosqualene Is More Critical to Its Correct Folding To Generate the Pentacyclic Scaffold than the Methyl-24 Group.2015
- Author(s)
  Hoshino T, Miyahara Y, Hanaoka M, Takahashi K, Kaneko I.
- Journal Title
  
  Chemistry-A European Journal
  
  Volume: 21 Pages: 15769-15784
- DOI
  10.1002/chem.201502389
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450150
[Journal Article] Identification of a new diterpene biosynthetic gene cluster that produces O-methylkolavelool in Herpetosiphon aurantiacus.2015
- Author(s)
  Nakano C, Oshima M, Kurashima N, Hoshino T.
- Journal Title
  
  ChemBioChem
  
  Volume: 16 Pages: 772-781
- DOI
  10.1002/cbic.201402652
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450150
[Journal Article] β-Amyrin biosynthesis: the critical role of steric volume at C-19 of 2,3-oxidosqualene for its correct folding to generate the pentacyclic scaffold.2014
- Author(s)
  Tsutomu HOSHINO, Yuki YAMAGUCHI , Kazunari TAKAHASHI, and Ryousuke ITO
- Journal Title
  
  Organic Letters
  
  Volume: 16 Pages: 3548-3551
- DOI
  10.1021/ol501498q
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450150
[Journal Article] β-Amyrin synthase from Euphorbia tirucalli. Steric bulk, not the π-electrons of Phe, at position 474 has a key role in affording the correct folding of the substrate to complete the normal polycyclization cascade.2014
- Author(s)
  Ito R, Masukawa Y, Nakada C, Amari K, Nakano C, Hoshino T.
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 12 Pages: 3836-3846
- DOI
  10.1039/c4ob00064a
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25450150
[Journal Article] Purification, kinetics, inhibitors and CD for recombinant β-amyrin synthase from Euphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases.2013
- Author(s)
  Ito R, Masukawa Y, Hoshino T.
- Journal Title
  
  FEBS J
  
  Volume: 280 Pages: 1267-1280
- DOI
  10.1111/febs.12119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450150
[Journal Article] Effect of cation-π interactions and steric bulk on the catalytic action of oxidosqualene cyclase: a case study of Phe728 of β-amyrin synthase from Euphorbia tirucalli L.2013
- Author(s)
  Ito R, Hashimoto I, Masukawa Y, Hoshino T.
- Journal Title
  
  Chem. Eur. J
  
  Volume: 19 Pages: 17150-17158
- DOI
  10.1002/chem.201301917
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] β―アミリン合成酵素：W534, L734及びY736残基の機能解析～CH-π相互作用の可能性について～2017
- Author(s)
  相場悠圭里、渡辺拓海、星野力、寺沢有里、仲野千秋
- Organizer
  日本農芸化学会
- Place of Presentation
  京都府、京都市東山区今熊野、京都女子大
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] β-Amyrin bosynthesis: catalytic function of the highly conserved aromatic amino acid residues2016
- Author(s)
  T. Hoshino, C. Nakada and I. Kaneko
- Organizer
  47th International symposium on essential oils
- Place of Presentation
  Nice, France
- Year and Date
  2016-09-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] ホペンとβ―アミリン合成酵素：基質（オキシド）スクアレンの23位メチル基の認識機構の比較について2016
- Author(s)
  寺澤有里・金子一輝・星野　力
- Organizer
  第60回香料・テルペンおよび精油化学に関する討論会要旨集
- Place of Presentation
  北海道、網走市、東京農業大オホーツク校
- Year and Date
  2016-10-29
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] Herpetosiphon aurantiacus 由来の新規ジテルペン環化酵素の機能解析2016
- Author(s)
  仲野千秋、倉嶋のどか、井出夕貴、星野力
- Organizer
  日本農芸化学会
- Place of Presentation
  北海道札幌市、札幌教育文化会館
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] スクアレンからアンブレインへの一段階酵素合成2016
- Author(s)
  奥野琴音、上田大次郎、星野力、佐藤努
- Organizer
  日本農芸化学会
- Place of Presentation
  北海道札幌市、札幌教育文化会館
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] 27-ノルオキシドスクアレンとホペン環化酵素による酵素反応生成物の同定（口頭発表）2016
- Author(s)
  渡辺拓海・南野　舞・仲野千秋・星野　力
- Organizer
  第60回香料・テルペンおよび精油化学に関する討論会要旨集
- Place of Presentation
  北海道、網走市、東京農業大オホーツク校
- Year and Date
  2016-10-29
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] β-アミリン合成酵素：基質末端メチル基の疎水性相互作用による環化制御2016
- Author(s)
  金子一輝、笹川智弘、仲野千秋、星野力
- Organizer
  日本農芸化学会
- Place of Presentation
  北海道札幌市、札幌教育文化会館
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] β―アミリン合成酵素：環化開始部位の近傍残基V483, W612とY736の機能解析2016
- Author(s)
  相場悠圭里・中川和也・伊藤大地・仲野千秋・星野　力
- Organizer
  第60回香料・テルペンおよび精油化学に関する討論会要旨集
- Place of Presentation
  北海道、網走市、東京農業大オホーツク校
- Year and Date
  2016-10-29
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] Herpetosiphon aurantiacus由来の新規ジテルペン環化酵素の機能解析2016
- Author(s)
  倉嶋のどか・仲野千秋・井出夕貴・J. S. DickSchat・星野　力
- Organizer
  第60回香料・テルペンおよび精油化学に関する討論会要旨集
- Place of Presentation
  北海道、網走市、東京農業大オホーツク校
- Year and Date
  2016-10-29
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] スクアレンーホペン環化酵素：末端メチル基をヒドロキシメチル基に置換した基質アナログの酵素反2016
- Author(s)
  寺澤有里、金子一輝、仲野千秋、星野力
- Organizer
  日本農芸化学会
- Place of Presentation
  北海道札幌市、札幌教育文化会館
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] スクアレン-ホペン環化酵素による27-noroxidosqualene の酵素反応産物2016
- Author(s)
  仲野千秋、渡辺拓海、南野舞、星野力
- Organizer
  日本農芸化学会
- Place of Presentation
  北海道札幌市、札幌教育文化会館
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] Cyclization of squalene from both termini:identification of an onoceroid synthase and enzymatic synthesis of ambrein2015
- Author(s)
  Daijiro UEDA, Tsutomu HOSHINO, Tsutomu SATO
- Organizer
  Pacifichem2015
- Place of Presentation
  ホノルル (アメリカ、ハワイ州）
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] β-Amyrin biosynthesis. Enzymatic reactions of the substrate analogs modified at the terminus2015
- Author(s)
  Ikki KANEKO, Yuri MIYAHARA, Masaki HANAOKA,Kazunari TAKAHASHI, Chiaki NAKANO, Ryousuke ITO,Tsutomu HOSHINO
- Organizer
  KAAB International Symposium 2015
- Place of Presentation
  Niigata University、新潟市
- Year and Date
  2015-09-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] Cation/π interaction as the catalytic mechanism found in beta-amyrin sythase2015
- Author(s)
  Chika NAKADA, Kanako AMARI, Ryosuke ITO, Tsutomu Hoshino
- Organizer
  40ｔｈ FEBS Congress
- Place of Presentation
  Berlin　（ドイツ）
- Year and Date
  2015-07-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] イネ由来のパルケオール合成酵素Y257残基の役割について2014
- Author(s)
  鈴木明日香、相川侑子、伊藤遼介、星野力
- Organizer
  日本農芸化学会
- Place of Presentation
  明治大学、農学部
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] スクアレン-ホペン環化酵素による10(15)位がエチル基に置換したスクアレン基質の環化反応2014
- Author(s)
  佐々木勇輔, 南野舞, 仲野千秋, 星野力
- Organizer
  日本農芸化学会
- Place of Presentation
  明治大学、農学部
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] b-アミリン合成酵素：基質の19位に位置するアルキル基のサイズが環化反応に及ぼす影響2014
- Author(s)
  髙橋一成、山口雄生、千葉彬文、阿部奈緒美、星野　力
- Organizer
  日本農芸化学会
- Place of Presentation
  明治大学、農学部
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] ミドリサンゴ β-アミリン合成酵素のY259及びW257の機能解析2014
- Author(s)
  仲田知佳, 天利佳奈子, 伊藤遼介, 星野力
- Organizer
  日本農芸化学会
- Place of Presentation
  明治大学,農学部
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] β−アミリン合成酵素のF474残基の機能解析2014
- Author(s)
  伊藤遼介、増川友夏里、仲田知佳、天利佳奈子、仲野千秋、星野力
- Organizer
  日本農芸化学会
- Place of Presentation
  明治大学、農学部
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] β–アミリン合成酵素　　基質の23位に位置するアルキル基のサイズが環化反応に及ぼす影響2014
- Author(s)
  金子一輝宮原悠里花岡正樹　星野　力
- Organizer
  日本農芸化学会
- Place of Presentation
  明治大学、農学部
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] β-アミリン合成酵素F728残基の更なる機能解析2013
- Author(s)
  伊藤遼介・増川友夏里・橋本一平・星野力
- Organizer
  第57回香料・テルペンおよび精油化学に関する討論会
- Place of Presentation
  埼玉大学,大学院理工学研究科
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] トリテルペン環化酵素：基質のメチル基が環化フォールデングや多環化反応へ及ぼす影響～ラノステロール及びβ―アミリン合成酵素を中心として2013
- Author(s)
  星野　力、千葉彬文、阿部奈緒美、花岡正樹、
- Organizer
  第55回天然有機化合物討論会講演要旨集
- Place of Presentation
  京都、同志社大学　寒梅館
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] Characterization of b-amyrin synthase from Euphorbia tirucalli L2013
- Author(s)
  R. Ito, Y. Masukawa and T. Hoshino
- Organizer
  Terpnet2013
- Place of Presentation
  Greece, Crete
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] スクアレンーホペン環化酵素：基質スクアレン19 位の立体サイズが環化反応に及ぼす影響
- Author(s)
  高橋一成、渡辺拓海、仲野千秋、星野力
- Organizer
  日本農芸化学会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-26 – 2015-03-30
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] β－アミリン合成酵素における基質末端のバルクサイズが環化反応に与える影響
- Author(s)
  金子一輝・宮原悠里・花岡正樹・仲野千秋・星野力
- Organizer
  第 58 回香料・テルペン回香料・テルペン回香料・テルペン回香料・テルペンおよび精油化学に関すおよび精油化学に関すおよび精油化学に関すおよび精油化学に関する討論会講演要旨集る討論会講演要旨集
- Place of Presentation
  和歌山大学
- Year and Date
  2014-09-20 – 2014-09-22
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] β－アミリン生合成：基質の19位のバルクサイズが環化反応に及ぼす影響について
- Author(s)
  高橋一成・山口雄生・伊藤遼介・星野力
- Organizer
  第58回香料・テルペンおよび精油化学に関する討論会
- Place of Presentation
  和歌山大学
- Year and Date
  2014-09-20 – 2014-09-22
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] β-アミリン合成酵素：基質の19 位に位置するアルキル基のサイズが環化反応に及ぼす影響
- Author(s)
  高橋一成・山口雄生・千葉彬史・阿部奈緒美・星野力
- Organizer
  日本農芸化学会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-26 – 2015-03-30
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] 病原性結核菌に特異的に存在するRv3378c のX 線構造解析とその触媒機構
- Author(s)
  Hsiu-Chien Chan、Xinxin Feng、Tzu-Ping Ko、仲野千秋、星野力、Eric Oldfield、Rey-Ting
- Organizer
  日本農芸化学会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-26 – 2015-03-30
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] スクアレン-ホペン環化酵素：基質スクアレン23 位の立体サイズが環化反応に及ぼす影響
- Author(s)
  金子一輝、宮原悠里、佐々木勇輔、仲野千秋、星野力
- Organizer
  日本農芸化学会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-26 – 2015-03-30
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] β-アミリン合成酵素：L734 およびV483 部位のかさ高さが環化反応に及ぼす影響
- Author(s)
  中川和也、仲田知佳、伊藤遼介、仲野千秋、星野力
- Organizer
  日本農芸化学会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-26 – 2015-03-30
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] β-アミリン合成酵素：M729 部位のかさ高さが環化反応に及ぼす影響
- Author(s)
  仲田知佳、中川和也、伊藤遼介、天利佳奈子、仲野千秋、星野力
- Organizer
  日本農芸化学会
- Place of Presentation
  岡山大学
- Year and Date
  2015-03-26 – 2015-03-30
- Data Source
  KAKENHI-PROJECT-25450150
[Presentation] β-アミリン合成酵素：10 位、15 位のエチル基置換体及び26-ノルオキシドスクアレンの環化反応
- Author(s)
  寺澤有里、高橋一成、佐々木勇輔、仲野千秋、星野力
- Organizer
  日本農芸化学会
- Place of Presentation
  和歌山大学
- Year and Date
  2015-03-26 – 2015-03-30
- Data Source
  KAKENHI-PROJECT-25450150

Hoshino Tsutomu 星野 力

Research Projects

Research Products

Triterpene cyclases: catalytic mechanism and substrate recognition by evaluating activities and subsrate analogsPrincipal Investigator

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[Book] 第2版マクマリー生物有機化学 基礎化学編2015

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[Book] 第４版マクマリー生物有機化学～基礎化学編～2015

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[Journal Article] βーAmyrin biosynthesis: catalytic mechanism and substrate recognition2017

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[Journal Article] β-Amyrin Biosynthesis: Effect of Steric Bulk at the 6-, 10- and 15-Positions in the 2,3-Oxidosqualene Backbone on Polycyclisation Cascades2017

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[Journal Article] Further Insight into Polycyclization Cascades of Acyclic Geranylfarnesol and its Acetate by Squalene-hopene Cyclase from Alicyclobacillus acidocaldarius.2016

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[Journal Article] β-Amyrin Biosynthesis: Promiscuity for Steric Bulk at Position 23 in the Oxidosqualene Substrate and the Significance of Hydrophobic Interaction between the Methyl Group at Position 30 and the Binding Site.2016

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[Journal Article] β-Amyrin Biosynthesis: The Methyl-30 Group of (3S)-2,3-Oxidosqualene Is More Critical to Its Correct Folding To Generate the Pentacyclic Scaffold than the Methyl-24 Group.2015

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[Journal Article] Identification of a new diterpene biosynthetic gene cluster that produces O-methylkolavelool in Herpetosiphon aurantiacus.2015

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[Journal Article] β-Amyrin biosynthesis: the critical role of steric volume at C-19 of 2,3-oxidosqualene for its correct folding to generate the pentacyclic scaffold.2014

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[Journal Article] β-Amyrin synthase from Euphorbia tirucalli. Steric bulk, not the π-electrons of Phe, at position 474 has a key role in affording the correct folding of the substrate to complete the normal polycyclization cascade.2014

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[Journal Article] Purification, kinetics, inhibitors and CD for recombinant β-amyrin synthase from Euphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases.2013

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[Journal Article] Effect of cation-π interactions and steric bulk on the catalytic action of oxidosqualene cyclase: a case study of Phe728 of β-amyrin synthase from Euphorbia tirucalli L.2013

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[Presentation] β―アミリン合成酵素：W534, L734及びY736残基の機能解析～CH-π相互作用の可能性について～2017

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Place of Presentation

Year and Date

Data Source

[Presentation] β-Amyrin bosynthesis: catalytic function of the highly conserved aromatic amino acid residues2016

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Organizer

Hoshino Tsutomu 星野力

[Book] 第2版マクマリー生物有機化学　基礎化学編2015