Kobayashi Shinichi 小林真一

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KOBAYASHI Shinichi 小林真一

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Researcher Number	20129836
Other IDs
Affiliation (Current)	2025: 昭和医科大学, 大学共同利用機関等の部局等, 特任教授
Affiliation (based on the past Project Information) *help	2004 – 2010: 聖マリアンナ医科大学, 医学部, 教授 1989 – 1990: 昭和大学, 医学部, 助教授
Review Section/Research Field	Principal Investigator Applied pharmacology Except Principal Investigator Digestive surgery / General pharmacology
Keywords	Principal Investigator DPD / ハプロタイプ / トランスポーター / 薬物代謝酵素 / 遺伝子多型 / 抗癌薬 / テーラーメード医療 / Haplotype / Transporter / Drug metabolizing enzymes / Gene polymorphism / Anti-cancer drugs / Tailor made therapy … More Except Principal Investigator … More Proteomics / Ischemia reperfusion / Zucker rat / Ischemic preconditioning / Steatohepatitis / ミトコンドリア蛋白 / mitochondria / 2D-DIGE / ischemic preconditioning / 脂肪肝 / プロテオミクス / Mitochoindrial protein / ミトコンドリア内膜電位 / 還元型グルタチオン比 / 酸化型 / 虚血再灌流障害 / ischemia reperfusion injury / proteomics / homozygous Zucker rat / Mitochondrial protein / Mitochoindria / Steatotic liver / 2-cystine peroxidase / superoxide dismutase 2 / ubiquinol cytochrome C reductase core protein I / 70%肝切除術 / JC-1 / 脂肪肝Zuckerラット / extrapolation / debrisoquine / trimethadione / antipyrine / model substrates / polymorphism / drug metabolizing enzymes / ラット / チトクロ-ムPー450 / エノキサシン / 外挿 / デブリソキン / トリメタジオン / アンチピリン / 指標薬物 / 多様性 / 肝薬物代謝酵素 / Oxaliplatin / Peroxiredoxin6 / Aldehyde dehydrogenase / オキザリプラチン / ジヌソイド閉塞症候群 / 化学療法関連肝障害 / Peroxiredoxin 6 / Blue liver / 肝障害 / 術前化学療法 / 肝切除 / 大腸癌肝転移 / sphingosine 1 phosphate / glutathione S-transferase M1 / sinusoidal obstruction syndrome / oxaliplatin-based chermotherapy / 大腸癌肝転移術前化学療法 Less

Proteomics analysis of a mechanism of sinusoidal endothelial cell injury after receiving oxaliplatin-based chemotherapy in colorectal liver metastases.
- Principal Investigator
  
  NAKANO Hiroshi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  St. Marianna University School of Medicine
The Practical Use Study of Tailor made medicine : Accerelate of genotyping System and Feedback System to Primary DoctorPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Shinichi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  St.Marianna University School of Medicine
The Tailor Made Therapy of Anti-Cancer DrugsPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Shinichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  St.Marianna University School of Medicine
Therapeutic approach against surgical injury of diseased liver : Proteomics approach
- Principal Investigator
  
  NAKANO Hiroshi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  St.Marianna University School of Medicine
Modification of the Hepatic Mitochondrial Proteome in Response to Ischemic Preconditioning Following Ischemia-Reperfusion Injury of the Rat Steatotic Liver.
- Principal Investigator
  
  NAKANO Hiroshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  St.Marianna University School of Medicine
Polymorphism of Hepatic Dung Metabolizing Enzymes and Extrapolation of its Data from Animal to Human
- Principal Investigator
  
  YASUHARA Hajime
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Showa University

All 2011 2009 2005

All Journal Article

[Journal Article] Comparative Study of Culture Conditions for Maintaining CYP3A4 and ATP-Binding Cassette Transporters Activity in Primary Cultured Human Hepatocytes.2011
- Author(s)
  Yuko Takeba, Naoki Matsumoto, Sachiko Takenoshita-Nakaya, Yoshie Harimoto, Toshio Kumai, Yuichi Kinoshita, Hiroshi Nakano, Takehito Ohtsubo, Shinichi Kobayashi
- Journal Title
  
  Journal of Pharmacological Sciences. vol.115、No.4
  
  Pages: 516-524
- NAID
  10029893533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590549
[Journal Article] Comparative study of culture conditions for maintaining CYP3A4 and ATP-binding cassette transporters activity in primary cultured human hepatocytes.2011
- Author(s)
  Takeba Y, Matsumoto N, Nakano H, Kobayashi S, et al.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 115 (4) Pages: 516-524
- NAID
  10029893533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591509
[Journal Article] Potential of lansoprazole as a novel probe for cytochrome P450 3A activity by measuring lansoprazole sulfone in human liver microsomes.2009
- Author(s)
  Yanagida Y, Watanabe M, Takeba Y,Kumai T, Matsumoto N, Hayashi M, Suzuki S, Kinoshita Y, Kobayashi S
- Journal Title
  
  Biol Pharm Bull. vol.32、No.8
  
  Pages: 1422-1426
- NAID
  130000117258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590549
[Journal Article] Utilization of human liver microsomes to explain individual differences in naclitaxel metabolism by CYP2C8 and CYP3A4.2005
- Author(s)
  小林真一, 他
- Journal Title
  
  J Pharmacol Sci. 97(1)
  
  Pages: 83-90
- Data Source
  KAKENHI-PROJECT-16591367

1. NAKANO Hiroshi (10241035)

# of Collaborated Projects: 5 results

# of Collaborated Products: 2 results
2. KUMAI Toshio (40139671)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. TANAKA Masami (00171801)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TAKENOSHITA Sachiko (10386948)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. YASUHARA Hajime (70053999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. UEDA Takako (00175499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kobayashi Shinichi 小林 真一

KOBAYASHI Shinichi 小林 真一

Research Projects

Research Products

Co-Researchers

Proteomics analysis of a mechanism of sinusoidal endothelial cell injury after receiving oxaliplatin-based chemotherapy in colorectal liver metastases.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Practical Use Study of Tailor made medicine : Accerelate of genotyping System and Feedback System to Primary DoctorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Tailor Made Therapy of Anti-Cancer DrugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Therapeutic approach against surgical injury of diseased liver : Proteomics approach

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modification of the Hepatic Mitochondrial Proteome in Response to Ischemic Preconditioning Following Ischemia-Reperfusion Injury of the Rat Steatotic Liver.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Polymorphism of Hepatic Dung Metabolizing Enzymes and Extrapolation of its Data from Animal to Human

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Comparative Study of Culture Conditions for Maintaining CYP3A4 and ATP-Binding Cassette Transporters Activity in Primary Cultured Human Hepatocytes.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Comparative study of culture conditions for maintaining CYP3A4 and ATP-binding cassette transporters activity in primary cultured human hepatocytes.2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Potential of lansoprazole as a novel probe for cytochrome P450 3A activity by measuring lansoprazole sulfone in human liver microsomes.2009

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Utilization of human liver microsomes to explain individual differences in naclitaxel metabolism by CYP2C8 and CYP3A4.2005

Author(s)

Journal Title

Data Source

Kobayashi Shinichi 小林真一

KOBAYASHI Shinichi 小林真一