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Kobayashi Shinichi  小林 真一

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KOBAYASHI Shinichi  小林 真一

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Researcher Number 20129836
Other IDs
Affiliation (Current) 2025: 昭和大学, 大学共同利用機関等の部局等, 特任教授
Affiliation (based on the past Project Information) *help 2004 – 2010: 聖マリアンナ医科大学, 医学部, 教授
1989 – 1990: 昭和大学, 医学部, 助教授
Review Section/Research Field
Principal Investigator
Applied pharmacology
Except Principal Investigator
Digestive surgery / General pharmacology
Keywords
Principal Investigator
DPD / ハプロタイプ / トランスポーター / 薬物代謝酵素 / 遺伝子多型 / 抗癌薬 / テーラーメード医療 / Haplotype / Transporter / Drug metabolizing enzymes / Gene polymorphism / Anti-cancer drugs / Tailor made therapy … More
Except Principal Investigator
… More Proteomics / Ischemia reperfusion / Zucker rat / Ischemic preconditioning / Steatohepatitis / ミトコンドリア蛋白 / mitochondria / 2D-DIGE / ischemic preconditioning / 脂肪肝 / プロテオミクス / Mitochoindrial protein / ミトコンドリア内膜電位 / 還元型グルタチオン比 / 酸化型 / 虚血再灌流障害 / ischemia reperfusion injury / proteomics / homozygous Zucker rat / Mitochondrial protein / Mitochoindria / Steatotic liver / 2-cystine peroxidase / superoxide dismutase 2 / ubiquinol cytochrome C reductase core protein I / 70%肝切除術 / JC-1 / 脂肪肝Zuckerラット / extrapolation / debrisoquine / trimethadione / antipyrine / model substrates / polymorphism / drug metabolizing enzymes / ラット / チトクロ-ムPー450 / エノキサシン / 外挿 / デブリソキン / トリメタジオン / アンチピリン / 指標薬物 / 多様性 / 肝薬物代謝酵素 / Oxaliplatin / Peroxiredoxin6 / Aldehyde dehydrogenase / オキザリプラチン / ジヌソイド閉塞症候群 / 化学療法関連肝障害 / Peroxiredoxin 6 / Blue liver / 肝障害 / 術前化学療法 / 肝切除 / 大腸癌肝転移 / sphingosine 1 phosphate / glutathione S-transferase M1 / sinusoidal obstruction syndrome / oxaliplatin-based chermotherapy / 大腸癌肝転移術前化学療法 Less
  • Research Projects

    (6 results)
  • Research Products

    (4 results)
  • Co-Researchers

    (6 People)
  •  Proteomics analysis of a mechanism of sinusoidal endothelial cell injury after receiving oxaliplatin-based chemotherapy in colorectal liver metastases.

    • Principal Investigator
      NAKANO Hiroshi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      St. Marianna University School of Medicine
  •  The Practical Use Study of Tailor made medicine : Accerelate of genotyping System and Feedback System to Primary DoctorPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Shinichi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      St.Marianna University School of Medicine
  •  The Tailor Made Therapy of Anti-Cancer DrugsPrincipal Investigator

    • Principal Investigator
      KOBAYASHI Shinichi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied pharmacology
    • Research Institution
      St.Marianna University School of Medicine
  •  Therapeutic approach against surgical injury of diseased liver : Proteomics approach

    • Principal Investigator
      NAKANO Hiroshi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      St.Marianna University School of Medicine
  •  Modification of the Hepatic Mitochondrial Proteome in Response to Ischemic Preconditioning Following Ischemia-Reperfusion Injury of the Rat Steatotic Liver.

    • Principal Investigator
      NAKANO Hiroshi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      St.Marianna University School of Medicine
  •  Polymorphism of Hepatic Dung Metabolizing Enzymes and Extrapolation of its Data from Animal to Human

    • Principal Investigator
      YASUHARA Hajime
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General pharmacology
    • Research Institution
      Showa University

All 2011 2009 2005

All Journal Article

  • [Journal Article] Comparative Study of Culture Conditions for Maintaining CYP3A4 and ATP-Binding Cassette Transporters Activity in Primary Cultured Human Hepatocytes.2011

    • Author(s)
      Yuko Takeba, Naoki Matsumoto, Sachiko Takenoshita-Nakaya, Yoshie Harimoto, Toshio Kumai, Yuichi Kinoshita, Hiroshi Nakano, Takehito Ohtsubo, Shinichi Kobayashi
    • Journal Title

      Journal of Pharmacological Sciences. vol.115、No.4

      Pages: 516-524

    • NAID

      10029893533

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590549
  • [Journal Article] Comparative study of culture conditions for maintaining CYP3A4 and ATP-binding cassette transporters activity in primary cultured human hepatocytes.2011

    • Author(s)
      Takeba Y, Matsumoto N, Nakano H, Kobayashi S, et al.
    • Journal Title

      J Pharmacol Sci

      Volume: 115 (4) Pages: 516-524

    • NAID

      10029893533

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591509
  • [Journal Article] Potential of lansoprazole as a novel probe for cytochrome P450 3A activity by measuring lansoprazole sulfone in human liver microsomes.2009

    • Author(s)
      Yanagida Y, Watanabe M, Takeba Y,Kumai T, Matsumoto N, Hayashi M, Suzuki S, Kinoshita Y, Kobayashi S
    • Journal Title

      Biol Pharm Bull. vol.32、No.8

      Pages: 1422-1426

    • NAID

      130000117258

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590549
  • [Journal Article] Utilization of human liver microsomes to explain individual differences in naclitaxel metabolism by CYP2C8 and CYP3A4.2005

    • Author(s)
      小林 真一, 他
    • Journal Title

      J Pharmacol Sci. 97(1)

      Pages: 83-90

    • Data Source
      KAKENHI-PROJECT-16591367
  • 1.  NAKANO Hiroshi (10241035)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 2 results
  • 2.  KUMAI Toshio (40139671)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 3.  TANAKA Masami (00171801)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 4.  TAKENOSHITA Sachiko (10386948)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  YASUHARA Hajime (70053999)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  UEDA Takako (00175499)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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