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AZUMA Hiroshi  東 洋

ORCIDConnect your ORCID iD *help
Researcher Number 20134736
Other IDs
Affiliation (based on the past Project Information) *help 2007 – 2008: 東京医科歯科大学, 生体材料工学研究所, 教授
2004: Institute of Biomaterials and Bioengineering, Department of Biosystem Regulation, Professor, 生体材料工学研究所, 教授
2002 – 2004: 東京医科歯科大学, 生体材料工学研究所, 教授
2003: Tokyo Medical and Dental University, Professor
2000 – 2001: 東京医科歯科大学, 生体工学研究所・分子設計部門, 助教授 … More
1999 – 2001: 東京医科歯科大学, 生体材料工学研究所, 助教授
1998: Ph.D., associate professor, Institute for Medical and Dental Engineering, Tokyo, 医学器材研究所, 助教授
1998: 東京医科歯科大学, 医用機材研究所, 助教授
1995 – 1998: 東京医科歯科大学, 医用器材研究所, 助教授
1996: TOKYO MEDICAL AND DENTAL UNIVERSITY,MEDICAL CHEMISTRY,FACULTY OF MEDICINE AND IN, 医用機材研究所, 助教授
1994: 東京医科歯科大学, 医用機材研究所, 助教授 Less
Review Section/Research Field
Principal Investigator
応用薬理学・医療系薬学
Except Principal Investigator
Urology / Pediatrics / Obstetrics and gynecology / Cerebral neurosurgery
Keywords
Principal Investigator
Aldose reductase / endothelin-1 / Ornithine aminotransferase / Ornithine decarboxylase / Polyamines / Endogenous NOS inhibitors / Enhanced arginase activity / Hyperglycemia / polyol pathway / 高血糖 … More / 内膜肥厚 / 内因性NOS阻害物質 / Endogenous arginase inhibitor / Acceleration of intimal hyperplasia / Vascular remodeling / Proline / Nitric oxide / Nitric oxide synthase / L-Arginine / Polyamine / OAT / ODC / Ornithine / DDAH / Arginase / NO synthase / omithine decarboxvlase (ODC) / putrescine / N^G-hydroxy-L-arginine / arginase活性亢進 / 内膜肥厚増悪 / Accelerated intimal hyperplasia / sorbitol / nitric oxide / hvperglycemia / endogenous NOS inhibitors / augmentation of intimal hvperplasia / alloxan / 内膜剥離術 / aldose reductase inhibitor (ARI) / ソルビトール / ポリオール経路 / 一酸化窒素 / エンドセリン-1 / 内膜肥厚の増悪 / アルドース還元酵素 / Extracellular matrices / Growth of smooth muscle cells / Endothelial cells / Vascular injury / Intimal hyperplasia / Inhibitors for NO synthesis / ADMA / L-NMMA / EDRF / p-53遺伝子発現 / p-53蛋白 / 内因性阻害物質 / NO合成酸素(NOS) / 動脈硬化 / 細胞外マトリックス / 高血圧 / 急性腎症 / 遠近調節 / 毛様体筋 / 細胞増殖 / NO … More
Except Principal Investigator
arginase / K^+ ion / EDHF / 一酸化窒素合成酵素(NOS) / 一酸化窒素(NO) / nitric oxide / cyclic GMP / penile erection / 陰茎海綿体 / 陰茎勃起 / 一酸化窒素 / エンドセリン / VIP / PACAP / prolonged QT / monocrotaline induced pulmonary artery hypertension model rats / in vivo electrophysiological studies / 心臓電気生理学的検査 / 病理的心筋リモデリング / 電気的心筋リモデリング / 肺高血圧ラット / QT延長 / モノクロタリン誘発肺高血圧ラット / 臨床心臓電気生理学的検査 / dimenthylarginine dimethylaminohydrolase (DDAH) / L-arginine / ornithine decarboxylase (ODC) / endogenos NOS inhibitors / nitric oxide synthase (NOS) / pulmonary vascular remodeling / pulmonary hypertension (PH) / DDAH / ODC / 内因性NO合成酵素阻害物質 / eNOS / 肺高血圧 / ジメチルアルギニン・ジメチルアミノハイドロラーゼ(DDAH) / L-アルギニン / オルニチン・デカルボキシラーゼ(ODC) / 内因性NO合成酵素阻害物質(NOS inhibitors) / アルギナーゼ / 肺血管リモデリング / 肺高血圧(PH) / metabolite(s) of P_<450> mono-oxygenase / CCh-induced relaxation / Hind-limb perfusion model / 内皮依存性過分極因子(EDHF) / 末梢血管 / H_2O_2 / 下肢還流モデル / 末梢血管抵抗 / 妊娠 / K^+ / 内皮依存性脱分極因子(EDHF) / ラットの下肢潅流モデル / ラット下肢潅流モデル / P_<450> mono-oxygenase代謝産物 / CCh誘発弛緩 / 後枝潅流モデル / endogenous NOS inhibitors / hyperglylcemia / ischemia / nitric oxide svnthase / corpus cavernosum / erectile dysfunction(ED) / 陰茎海面体 / guanylate cyclase / NOS / 勃起障害 / 内因性NOS阻害物質 / 高血糖 / 虚血 / nitric oxide synthase / impotence / vasoactive intestinal polypeptide (VIP) / pituitary adenylate activation polypeptide (PACAP) / neuropeptide / neurotransmitter / 精管 / アドレナリン受容体 / 尿道 / ムスカリン受容体 / インポテンス / 神経ペプチド / 神経伝達物質 / 子宮筋弛緩 / 子宮筋収縮 / ENDOTHELIN / INSULIN-LIKE GROWTH FACTOR (IGF) / ANDROGEN / PROSTATE / 培養細胞 / 成長因子 / アンドロジェン / パラクリン / IGF-II / エントセリン / インスリン様成長因子 / アンドロゲン / 前立腺 / 新生内膜増殖性病変 / 肺動脈性高血圧 / PAHモデルラット / 肺小動脈理モデリング / 血管内皮細胞増殖因子受容体阻害剤 / 精巣・卵巣摘出 / 性ステロイド / 性差 / 血管内皮細胞増殖因子受容体阻害剤SU-5416 / 肺細小動脈新生内膜増殖性変化 / 肺動脈性肺高血圧 / mRNA / SAH Less
  • Research Projects

    (12 results)
  • Research Products

    (13 results)
  • Co-Researchers

    (20 People)
  •  Effects of sex steroids on pulmonary hypertension-From the standpoint of sex difference in idiopathic pulmonary arterial hypertension-

    • Principal Investigator
      DOI Shouzaburou
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Tokyo Medical and Dental University
  •  Research for the clarification of the modulating mechanisms of pulmonary vascular remodeling associated with pulmonary hypertension

    • Principal Investigator
      DOI Shozaburo
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Tokyo Medical and Dental University
  •  Interaction Between Electrical and Pathological Myocardial Remodeling Induced by Right and Left Ventricular Pressure Overload

    • Principal Investigator
      WAKIMOTO Hiroko
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Tokyo Medical and Dental University
  •  Acceleration of intinul hyperplasia by the enhanced arginase activity due to hyperglycemiaPrincipal Investigator

    • Principal Investigator
      AZUMA Hiroshi
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tokyo Medical and Dental University
  •  Research for the role of endothelium-dependent relaxation in the change of maternal circulation during pregnancy

    • Principal Investigator
      SAKAMOTO Shuichi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Tokyo Medical and Dental University
  •  Possible involvement of facilitated aldose reductase activity in the accelerated vascular remodeling in rabbits with alloxan-induced hyperglycemiaPrincipal Investigator

    • Principal Investigator
      AZUMA Hiroshi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tokyo Medical and Dental University
  •  Role of endogenous nitric oxide synthase inhibitors in penile erection and their potential use in the treatment of erectile dysfunction.

    • Principal Investigator
      TSUJII Toshihiko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Dokkyo University School of Medicine
      Tokyo Medical and Dental University
  •  PACAPによる脳幹部機能異常の調節に関する研究

    • Principal Investigator
      ISOTANI Eiji
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Tokyo Medical and Dental University
  •  Study of the role of pituitary adenylate cyclase activating polypeptide (PACAP) as a neurotransmitter in the urogenital organs.

    • Principal Investigator
      TSUJII Toshihiko
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Tokyo Medical and Dental University School of Medicine
  •  子宮筋における各種収縮・弛緩因子の相互作用による収縮弛緩調節に関する研究

    • Principal Investigator
      ASO Takeshi
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Tokyo Medical and Dental University
  •  Regulation of NOS activity by the endogenous inhibitors and modification of hyperplastic vascular diseases with the inhibitors.Principal Investigator

    • Principal Investigator
      AZUMA Hiroshi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tokyo Medical & Dental University
  •  REGULATION OF PROSTATIC GROWTH AND FUNCTION BY EPITHELIAL-STROMAL INTERACTION AND TESTICULAR FACTOR.

    • Principal Investigator
      ISHIZAKA Kazuhiro
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      TOKYO MEDICAL AND DENTAL UNIVERSITY

All 2005 2004 2003 2002

All Journal Article

  • [Journal Article] Accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity attenuated dimethylarginine dimethylaminohydrolase activity and2005

    • Author(s)
      Loyaga-Rendon RY, Sakamoto S, Beppu M, Aso T, Azuma H
    • Journal Title

      Atherosclerosis 178

      Pages: 231-239

    • Data Source
      KAKENHI-PROJECT-14572152
  • [Journal Article] Involvement of accumulated endogenous NOS inhibitors and accelerated arginase activity in impairing the NO production in pulmonary arterial hypertension of the rat.2005

    • Author(s)
      Sasaki A, Doi S, Wakimoto H, Takahashi R, Azuma H.
    • Journal Title

      American Journal of Respiratory and Critical Care Medicine Vol 2

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591090
  • [Journal Article] Involvement of accumulated endogenous NOS inhibitors and accelerated arginase activity in impairing the NO production in pulmonary arterial hypertension of the Rat.2005

    • Author(s)
      Sasaki A, Doi S, Wakimoto H, Takahashi R, Azuma H.
    • Journal Title

      American Journal of Respiratory and Critical Care Medicine 171(7)

    • Data Source
      KAKENHI-PROJECT-15591090
  • [Journal Article] Mediators involved in decreasing peripheral vascular resistance with carbachol in the rat hind limb perfusion model.2005

    • Author(s)
      Loyaga-Rendon RY, Sakamoto S, Aso T, Iwasaki-Kurashige, Takahashi R, Azuma H.
    • Journal Title

      Journal of Pharmacological Science (in press)

    • NAID

      10025728953

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14572152
  • [Journal Article] Involvement of accumulated endogenous NOS inhibitors and accelerated arginase activity in impairing the NO production in pulmonary arterial hypertension of the rat2005

    • Author(s)
      Sasaki A, Doi S, Wakimoto H, Takahashi R, Azuma H
    • Journal Title

      American Thoracic Society 2005 San Diego International Conference Abstracts Issue Volume 2

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591090
  • [Journal Article] Accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, attenuated dimethylarginine dimethylaminohydrolase activity and intimal hyperplasia in premenopausal human uterine arteries2005

    • Author(s)
      Loyaga-Rendon RY, Sakamoto S, Beppu M, Aso T, Ishizaka M, Takahashi R, Azuma H.
    • Journal Title

      Atherosclerosis 178

      Pages: 231-239

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14572152
  • [Journal Article] Involvement of increased arginase activity in the impaired cavernosal relaxation with aging in the rabbit2004

    • Author(s)
      Sakai Y, Masuda H, Kihara K, Kurosaki E., Yamauchi Y, Azuma H
    • Journal Title

      Journal of Pharmacological Sciencee 94(Suppl I)

      Pages: 182-182

    • Data Source
      KAKENHI-PROJECT-14572152
  • [Journal Article] Modulation of NO production by arginase in the rabbit lower urinary tract2004

    • Author(s)
      Yano M, Masuda H, Kawano K, Sakai Y, Kihara K, Azuma H
    • Journal Title

      Journal of Pharmacological Science 94(Suppl I)

      Pages: 264-264

    • Data Source
      KAKENHI-PROJECT-14572152
  • [Journal Article] Roles of endogenous NOS inhibitors and endothelin-1 for regulating myometrial contractions during gestation of the rat.2004

    • Author(s)
      Momohara Y, Sakamoto S, Obayashi S, Aso T, Ooto M, Azuma H.
    • Journal Title

      Molecular Human Reproduction 10

      Pages: 505-512

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14572152
  • [Journal Article] Possible involvement of facilitated polyol pathway in augmentation of intimal hyperplasia in rabbits with alloxan-induced hyperglycemia2003

    • Author(s)
      Goto M, Yamauchi Y, Kurosaki E, Azuma H.
    • Journal Title

      Journal of Cardiovascular Pharmacology 41

      Pages: 265-227

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14572152
  • [Journal Article] Possible involvement of facilitated polyol pathway in augmentation of intimal hyperplasia in rabbits with alloxan-induced hyperglycemia.2003

    • Author(s)
      Goto M, Yamauchi Y, Kurosaki E, Azuma H.
    • Journal Title

      Journal of Cardiovascular Pharmacology 41

      Pages: 265-275

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14572152
  • [Journal Article] Changes in the responsiveness of peripheral resistant vessels during pregnancy of the rat.2002

    • Author(s)
      R.Loyaga, S.Sakamoto, T.Aso, Y.Yamauchi, H.Azuma
    • Journal Title

      Proceedings of 54^th Annual Congress of the Japan Society of Obstetrics and Gynecology

      Pages: 39-44

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13671700
  • [Journal Article] Changes in the responsiveness of peripheral resistant vessels during pregnancy of the rat2002

    • Author(s)
      R.Loyaga, S.Sakamoto, T.Aso, Y.Yamauchi, H.Azuma
    • Journal Title

      Proceedings of 54^<th> Annual Congress of the Japan Society of Obstetrics and Gynecology

      Pages: 39-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13671700
  • 1.  DOI Shouzaburou (80262195)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 3 results
  • 2.  OBAYASHI Satoshi (10262180)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 1 results
  • 3.  TSUJII Toshihiko (90217307)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  ISOTANI Eiji (90251529)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  ASO Takeshi (60093176)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 6.  KUBOTA Toshiro (50126223)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  KAGEYAMA Yukio (10211153)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  WAKIMOTO Hiroko (60345296)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 9.  ISHIZAKA Kazuhiro (60168218)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  KITAHARA Satoshi (10186257)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KIHARA Kazunori (40161541)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  MORITA Takashi (10006819)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  MASUDA Hitoshi (80301167)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 14.  SAKAMOTO Shuichi (90242198)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 15.  FURUKAWA Tetsushi (80251552)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  今村 公俊 (40422472)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  佐々木 章人 (20328454)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  己斐 秀樹 (20280969)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  増田 均 (60323680)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  鈴木 龍太
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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