KITADE Yukio 北出幸夫

… Alternative Names

KITADE YUKIO 北出幸夫

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Researcher Number	20137061
Other IDs
External Links
Affiliation (Current)	2025: 愛知工業大学, 工学部, 教授
Affiliation (based on the past Project Information) *help	2017: 愛知工業大学, 工学部, 教授 2012 – 2014: 岐阜大学, 工学部, 教授 2001 – 2007: 岐阜大学, 工学部, 教授 1998 – 2000: 岐阜大学, 工学部, 助教授 1994 – 1995: 岐阜大学, 工学部, 助教授 … More 1992 – 1993: 岐阜薬科大学, 薬学部, 助手 1988 – 1989: 岐阜薬科大学, 薬学部, 助手 1986: Gifu Pharm. Univ., Faculty of Pharmacy, Assistant, 薬学部, 助手 Less
Review Section/Research Field	Principal Investigator Biological Sciences / 医薬分子機能学 / Drug development chemistry Except Principal Investigator Chemical pharmacy / Drug development chemistry
Keywords	Principal Investigator SAH hydrolase / 抗マラリア薬 / 抗ウイルス薬 / 遺伝子組換え酵素 / 炭素環ヌクレオシド / アシクロヌクレオシド / 2-5A / antisense / acyclonucleoside / 有機化学 … More / 生理活性 / 酵素 / 感染症 / ゲノム / messenger RNA / oligomer / ribonuclease / 2-5A-antisense / メッセンジャーRNA / 核酸オリゴマー / リボヌクレアーゼ / 2-5A-アンチセンス / アンチセンス核酸 / anti-viral drug / 2-5A-antisense chimera / Rnase L / interferon / 2-5A system / 抗ウイルス作用 / RNaseL / アンチセンス / 2-5Aアンチセンス・キメラ / RNase L / インターフェロン / 2-5Aシステム / inhibitor of protein synthesis / carbocyclic nucleoside / affinity-labeling probe / mechanism-based inhibitor / recombinant enzyme / anti-viral agent / 遺伝子組換酵素 / 抗ウィルス薬 / タンパク質合成阻害 / アフィニティーラベル化プローブ / 機構依存型阻害剤 / purine nucleoside / diisobutylaluminum hydride / reduction / antiviral agent / 水素化ジイソブチルアルミニウム / プリンヌクレオシド / 水素化ジイリブチルアルミニウム / 還元反応 / ＰＥＴプローブ / ラベル標識 / ＲＮＡ創薬 / ドラッグデリバリー / バイオイメージング / PETプローブ / 薬物動態 / ラベル標識化 / クリック反応 / オリゴヌクレオチド / RNA創薬 / 大腸がん / miRNA / 人工核酸 / がん治療 / RNA / 医薬品開発 / X線結晶構造解析 / 酵素阻害薬 / マラリア / ノルアリステロマイシン / ネプラノシンA / 酵素阻害剤 / 熱帯熱マラリア原虫 / mRNAのキャップ構造 / 抗癌薬 / SAHase … More Except Principal Investigator 核酸医薬 / 複素環N-オキシド / DNA鎖切断反応 / 水酸ラジカル / 光酸化反応 / 生理活性 / 有機化学 / 薬学 / 効率的合成 / ポスト修飾 / CuAAC / 簡便合成 / 分解酵素耐性 / 環境応答 / 機能性短鎖RNA / Functional molecule / Photo-induced single-electron transfer / Chemical model / Pyrimidopteridine N-oxide / Dehydrogenation / Oxygenation / Photooxidation / Heterocyclic N-oxide / 生体内代謝の化学モデル / 光化学反応機構 / 光化学的酸素原子添加反応 / 含窒素複素環Nーオキシド・ピリミド[54ーg]プテリジンーNーオキシド / 機能的分子 / 光誘起電子移動 / 生体反応モデル / ピリミドプテリジンN-オキシド / 機能性分子 / 光励起電子移動 / 化学モデル / ピリミドプテリジンNーオキシド / 脱水素反応 / 酸素原子添加反応 / 光化学的酸化 / 複素環Nーオキシド / antibacterial activity / regio-selective chemical modification / transition-state analogs / <beta> -lactam antibiotics / β-ラクタマーゼ阻害作用 / 抗菌作用 / 位置選択的な化学修飾 / 遷移状態類似体 / β-ラクタム系抗生物質 / オリゴ核酸修飾 / siRNA / 蛋白質障害 / 核酸障害 / プリンヌクレオシド / 一電子移動反応 / 機能性複素環N-オキシド Less

Development of sophisticated small RNAs utilizing the properties of functional groups
- Principal Investigator
  
  KITAMURA Yoshiaki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu University
Owing to the development of RNA medicine, discovery of practical RNA molecules and synthesis of nucleic acid PET probesPrincipal Investigator
- Principal Investigator
  
  KITADE Yukio
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu University
Novel modification method of oligonucleotides for siRNA medicine
- Principal Investigator
  
  KITAMURA Yoshiaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu University
がん治療を指向する高機能性マイクロRNAの開発Principal Investigator
- Principal Investigator
  
  北出幸夫
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
X線結晶構造解析を基盤とする熱帯熱マラリア原虫酵素の特異的阻害薬の開発Principal Investigator
- Principal Investigator
  
  北出幸夫
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
Development of a new generation of 2-5A-antisense and its property for the regulation of gene expression.Principal Investigator
- Principal Investigator
  
  KITADE Yukio
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu University
ゲノム情報に基づく耐性マラリアの新規化学療法薬の開発研究Principal Investigator
- Principal Investigator
  
  北出幸夫
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
ゲノム情報に基づく耐性マラリアの新規化学療法薬の開発研究Principal Investigator
- Principal Investigator
  
  北出幸夫
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Gifu University
STUDY ON DRUG-DESIGN AND SYNTHESIS OF NOVEL 2-5A-ANTISENSE CHIMERASPrincipal Investigator
- Principal Investigator
  
  KITADE Yukio
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  GIFU UNIVERSITY
組換えSAHaseを標的とするマラリア治療薬の開発研究Principal Investigator
- Principal Investigator
  
  北出幸夫
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gifu University
SAHaseの触媒機能探索と医薬品開発を指向するリード化合物の分子設計Principal Investigator
- Principal Investigator
  
  北出幸夫
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gifu University
STUDY ON CATALYTIC REACTION MECHANISM OF ADENOSYLHOMOCYSTEINE HYDRLASE AND SYNTHESIS OF THEIR MECANISM -BASED INHIBITORSPrincipal Investigator
- Principal Investigator
  
  KITADE Yukio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  GIFU UNIVERSITY
A New Method for the Preparation of Acyclonucleosides as a Potential Antiviral AgentsPrincipal Investigator
- Principal Investigator
  
  KITADE Yukio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  GIFU UNIVERSITY
複素環N-オキシドを用いる高効率水酸ラジカル発生法の開発とその応用
- Principal Investigator
  
  牧敬文
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Gifu Pharmaceutical University
機能性複素環N-オキシドによる生体物質及び外来物質の光酸化反応
- Principal Investigator
  
  MAKI Yoshifumi
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Gifu Pharmaceutical University
Construction of Heterocyclic N-oxides possessing Highly Photooxidative Capacity and its Application
- Principal Investigator
  
  MAKI Yoshifumi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Gifu Pharmaceutical University
Synthesis of Transition-state Analogs of Penicillin and their Biological Activity
- Principal Investigator
  
  MAKI Yoshifumi
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Gifu Pharmaceutical University

All 2018 2017 2016 2015 2014 2013 2012 2011 2007 Other

All Journal Article Presentation Patent

[Journal Article] Nucleobase azide-ethynylribose click chemistry contributes to stabilizing oligonucleotide duplexes and stem-loop structures2017
- Author(s)
  Yoshiaki Kitamura, Ryo Asakura, Koki Terazawa, Aya Shibata, Masato Ikeda, Yukio Kitade
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 27 Issue: 12 Pages: 2655-2658
- DOI
  10.1016/j.bmcl.2017.04.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18911
[Journal Article] Introduction of 2-O-benzyl abasic nucleosides to the 3'-overhang regions of siRNAs greatly improves nuclease resistance2017
- Author(s)
  Yuki Nagaya, Yoshiaki Kitamura, Aya Shibata, Masato Ikeda, Yukihiro Akao, Yukio Kitade
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 27 Issue: 24 Pages: 5454-5456
- DOI
  10.1016/j.bmcl.2017.10.070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18911
[Journal Article] Practical modification of peptides using ligand-free copper-catalyzed azide-alkyne cycloaddition2016
- Author(s)
  Yoshiaki Kitamura, Ryo Sakamoto, Takao Shiraishi, Haruka Oguri, Satoshi Ohno, Yukio Kitade
- Journal Title
  
  Tetrahedron
  
  Volume: 72 Issue: 27-28 Pages: 4016-4021
- DOI
  10.1016/j.tet.2016.05.029
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K18911
[Journal Article] Bioenergetics and Gene Silencing Approaches for Unraveling Nucleotide Recognition by the Human EIF2C2/Ago2 PAZ Domain2014
- Author(s)
  Mahmoud Kandeel, Abdullah Al-Taher, Remi Nakashima, Tomoya Sakaguchi, Ali Kandeel, Yuki Nagaya, Yoshiaki Kitamura, Yukio Kitade
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 5 Pages: e94538-e94538
- DOI
  10.1371/journal.pone.0094538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390025
[Journal Article] Synthesis of ethynylbenzene-substituted glycol as a versatile probe for labeling oligonucleotides2014
- Author(s)
  Qin Ren, Kana Tsunaba, Yoshiaki Kitamura, Remi Nakashima, Aya Shibada, Masato Ikeda, Yukio Kitade.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 24 Issue: 6 Pages: 1519-1522
- DOI
  10.1016/j.bmcl.2014.01.082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390025
[Journal Article] Cu/HP20-Catalyzed Solvent-Free Huisgen Cycloaddition at Ordinary Temperatures2014
- Author(s)
  Yoshiaki Kitamura, Kazumi Taniguchi, Tomohiro Maegawa, Yasunari Monguchi, Yukio Kitade, Hironao Sajiki
- Journal Title
  
  HETEROCYCLES
  
  Volume: 88 Issue: 1 Pages: 233-243
- DOI
  10.3987/com-13-s(s)6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390025
[Journal Article] In silico molecular docking analysis of the human Argonaute2 PAZ domain reveals insights into RNA interference2013
- Author(s)
  M. Kandeel, Y. Kitade
- Journal Title
  
  Journal of computer-aided molecular design
  
  Volume: 27 Issue: 7 Pages: 605-614
- DOI
  10.1007/s10822-013-9665-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390025
[Journal Article] Chemically Modified Synthetic microRNA-205 Inhibits the Growth of Melanoma Cells In Vitro and In Vivo.2013
- Author(s)
  Noguchi, S., Iwasaki, J., Kumazaki, M., Mori, T., Maruo, K., Saka,i H., Yamada, N., Shimada, K., Naoe, T., Kitade, Y., and Akao, Y.
- Journal Title
  
  Mol. Ther.
  
  Volume: 21 Issue: 6 Pages: 1204-1211
- DOI
  10.1038/mt.2013.70
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23580439, KAKENHI-PROJECT-24390025, KAKENHI-PROJECT-24580459
[Journal Article] Synthesis of oligonucleotides with glucosamine at the 3'-position and evaluation of their biological activity2013
- Author(s)
  Xiong Luo, Takahiro Sugiura, Remi Nakashima, Yoshiaki Kitamura, Yukio Kitade
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 23 Issue: 14 Pages: 4157-4161
- DOI
  10.1016/j.bmcl.2013.05.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390025
[Journal Article] Computational Analysis of siRNA Recognition by the Ago2 PAZ Domain and Identification of the Determinants of RNA-Induced Gene Silencing2013
- Author(s)
  Kandeel Mahmoud, Kitade, Yukio
- Journal Title
  
  PLOS ONE
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390025
[Journal Article] Chemically modified siRNAs and miRNAs bearing urea/thioures-bridged aromatic compounds at their 3'-end for RNAi therapy2013
- Author(s)
  Yoshiaki Kitamura, Yuki Masegi, Shunsuke Ogawa, Remi Nakashima, Yukihiro Akao, Yoshihito Ueno, Yukio Kitade
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 21 Issue: 15 Pages: 4494-4501
- DOI
  10.1016/j.bmc.2013.05.046
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24390025
[Journal Article] Synthesis and biological properties of chemically modified siRNAs bearing 1-deoxy-D-ribofuranose in their 3'-overhang region2012
- Author(s)
  Kazumi Taniho, Remi Nakashima, Mahmoud Kandeel, Yoshiaki Kitamura, Yukio Kitade
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 22 Issue: 7 Pages: 2518-2521
- DOI
  10.1016/j.bmcl.2012.01.132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790107
[Journal Article] Stereoselective synthesis of 1-deoxy-1-ethynyl-β-D-ribofuranose as a versatile scaffold2012
- Author(s)
  Yoshiaki Kitamura, Kana Edayoshi, Yukio Kitade
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 53 Issue: 51 Pages: 6987-6989
- DOI
  10.1016/j.tetlet.2012.10.053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790107, KAKENHI-PROJECT-24390025
[Journal Article] Synthesis and biological properties of chemically modified siRNAs bearing 1-deoxy-D-ribofuranose in their 3′-overhang region2012
- Author(s)
  Kazumi Taniho、Remi Nakashima、Mahmoud Kandeel、 Yoshiaki Kitamura、 Yukio Kitade
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 22 Pages: 2518-2521
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790107
[Patent] ｵﾘｺﾞﾇｸﾚｵﾁﾄﾞ誘導体及びそれを用いたｵﾘｺﾞﾇｸﾚｵﾁﾄﾞ構築物並びにそれらの製造方法2015
- Inventor(s)
  北出　幸夫、柴田　綾
- Industrial Property Rights Holder
  国立大学法人岐阜大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2015-060689
- Filing Date
  2015-03-24
- Data Source
  KAKENHI-PROJECT-24390025
[Patent] RNA干渉剤、その製造方法及びその利用2013
- Inventor(s)
  北出幸夫　中島礼美
- Industrial Property Rights Holder
  国立大学法人岐阜大学
- Industrial Property Rights Type
  特許
- Filing Date
  2013-11-29
- Overseas
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] 塩基部欠損ヌクレオシド類を 3’末端に有する siRNA の合成と性質評価2018
- Author(s)
  長屋優貴, 喜多村徳昭, 柴田綾, 池田将, 赤尾幸博, 北出幸夫
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K18911
[Presentation] Nucleobase azide-ethynylribose click chemistry: stabilizing oligonucleotide duplexes and stem-loop structures2017
- Author(s)
  Yoshiaki Kitamura, Ryo Asakura, Koki Terazawa, Aya Shibata, Masato Ikeda, Yukio Kitade
- Organizer
  第44回国際核酸化学シンポジウム（ISNAC2017）・日本核酸化学会第1回年会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18911
[Presentation] リボース誘導体を母核とする新規traceless型リンカーの開発2017
- Author(s)
  寺澤康輝, 喜多村徳昭, 長屋優貴, 柴田綾, 池田将, 北出幸夫
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2017
- Data Source
  KAKENHI-PROJECT-16K18911
[Presentation] Nucleobase azide-ethynylribose click chemistry contributes to stabilizing oligonucleotide duplexes and stem-loop　structures2017
- Author(s)
  Yoshiaki Kitamura, Ryo Asakura, Koki Terazawa, Aya Shibata, Masato Ikeda, Yukio Kitade
- Organizer
  第26回国際複素環化学会議（26th ISHC Congress）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18911
[Presentation] Synthesis of chemically modified siRNAs bearing high affinity molecules for human Argonaute 2 PAZ domain and their biological properties2016
- Author(s)
  Yoshiaki Kitamura, Yuki Nagaya, Kazuhito Kondo, Ryo Asakura, Qin Ren, Mahmoud Kandeel, Aya Shibata, Masato Ikeda, Yukio Kitade
- Organizer
  第43回国際核酸化学シンポジウム（ISNAC2016）
- Place of Presentation
  熊本大学（熊本）
- Year and Date
  2016-09-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18911
[Presentation] トリアゾール環形成による二本鎖核酸の安定化2016
- Author(s)
  朝倉領、喜多村徳昭、柴田綾、池田将、北出幸夫
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2016
- Place of Presentation
  長良川国際会議場（岐阜）
- Year and Date
  2016-10-30
- Data Source
  KAKENHI-PROJECT-16K18911
[Presentation] グルコサミン結合型 RNA 分子の合成とその機能2015
- Author(s)
  柴田綾、溝口真帆代、喜多村徳昭、池田将、北出幸夫
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸学院大学
- Year and Date
  2015-03-26
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] 生体親和性グルコサミン結合型RNA分子の合成2014
- Author(s)
  溝口真帆代、柴田綾、喜多村徳昭、池田将、北出幸夫
- Organizer
  第45回中部化学関係学協会支部連合秋季大会
- Place of Presentation
  中部大学
- Year and Date
  2014-11-30
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] オフターゲット効果の回避を目指した3'末端化学修飾siRNAの合成とその評価2014
- Author(s)
  河出美和、中島礼美、喜多村徳昭、北出幸夫
- Organizer
  日本薬学会　第134年会
- Place of Presentation
  熊本市総合体育館
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] ＲＮＡ医薬の開発を目指した3’-末端修飾ＲＮＡの合成と機能評価2014
- Author(s)
  喜多村徳昭、小川俊介、Mohmoud Kandeel、北出幸夫
- Organizer
  第60 回日本薬学会東海支部総会・大会2014
- Place of Presentation
  鈴鹿医療科学大学白子キャンパス
- Year and Date
  2014-07-10
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] クリック反応によるＰＥＴラベル化ＲＮＡ合成と評価2014
- Author(s)
  牧野洋平、仁欽、喜多村徳昭、北出幸夫
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2014（第24回日本病院薬剤師会東海ブロック学術大会・平成26年度日本薬学会東海支部例会）
- Place of Presentation
  静岡県立大学
- Year and Date
  2014-11-09
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] Synthesis of oligonucleotides possessing ethynyl groups and rapid ligand-free click reaction for PET labeling2014
- Author(s)
  Yoshiaki Kitamura, Qin Ren, Kana Tsunaba, Aya Shibata, Masato Ikeda, Yukio Kitade
- Organizer
  第41回国際核酸化学シンポジウム
- Place of Presentation
  北九州国際会議場
- Year and Date
  2014-11-05
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] 化学修飾siRNAの合成とそのオフターゲット効果2014
- Author(s)
  河出美和、中島礼美、喜多村徳昭、北出幸夫
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2014（第24回日本病院薬剤師会東海ブロック学術大会・平成26年度日本薬学会東海支部例会）
- Place of Presentation
  静岡県立大学
- Year and Date
  2014-11-09
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] Synthesis and properties of modified siRNAs bearing 1,2-dideoxy-D-ribofuranose in their 3’-dangling end2013
- Author(s)
  Yuki Nagaya, Kazumi Taniho, Ayaka Kobayashi, Mahoyo Mizoguchi, Yoshiaki Kitamura, Remi Nakashima, Masato Ikeda, Yukio Kitade
- Organizer
  第40回　国際核酸化学シンポジウム
- Place of Presentation
  神奈川大学
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] Chemical modifications at the 3’-terminus of siRNA for suppressing off-target effects2013
- Author(s)
  Remi Nakashima, Miwa Kawade, Yoshiaki Kitamura, Masato Ikeda, Yukio Kitade
- Organizer
  第40回　国際核酸化学シンポジウム
- Place of Presentation
  神奈川大学
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] エチニルベンゼン置換型グリコールを導入した核酸オリゴマーの合成とその性質2013
- Author(s)
  仁欽、綱場佳奈、喜多村徳昭、柴田綾、池田将、北出幸夫
- Organizer
  第59回　日本薬学会東海支部総会・大会
- Place of Presentation
  名城大学
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] Synthesis of the chemically modified miRNAs and their anticancer activities2013
- Author(s)
  Yukio Kitade
- Organizer
  MicroRNAs Europe 2013 Symposium
- Place of Presentation
  ケンブリッジ大学（イギリス）
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] Synthesis and evaluation of the chemically modified dangling ends on double-stranded RNA: an RNA interference investigation2013
- Author(s)
  Shunsuke Ogawa, Remi Nakashima, Mahmoud Kandeel, Yoshiaki Kitamura, Masato Ikeda, Yukio Kitade
- Organizer
  第40回　国際核酸化学シンポジウム
- Place of Presentation
  神奈川大学
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] RNA創薬を目指す塩基部欠損型デオキシリボヌクレオシドの合成2013
- Author(s)
  長屋優貴、中島礼美、喜多村徳昭、池田将、北出幸夫
- Organizer
  第59回　日本薬学会東海支部総会・大会
- Place of Presentation
  名城大学
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] Stereoselective synthesis of 1-deoxy-1-ethynyl-β-D-ribofuranose and its applications2012
- Author(s)
  Kana Edayoshi 、 Yoshiaki Kitamura、Masato Ikeda 、 Yukio Kitade
- Organizer
  第39回国際核酸化学シンポジウム
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22790107
[Presentation] Synthesis of urea-substituted microRNAs possessing nuclease-resistance and their anticancer activities2012
- Author(s)
  北出幸夫
- Organizer
  第20回国際ヌクレオシド, ヌクレオチド, 核酸ラウンドテーブル
- Place of Presentation
  モントリオール(カナダ)
- Year and Date
  2012-08-05
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] 1-Deoxy-1-ethynyl-β-D-ribofuranoseの立体選択的合成2012
- Author(s)
  枝吉佳奈、喜多村徳昭、北出幸夫
- Organizer
  平成 24 年度日本薬学会東海支部例会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-22790107
[Presentation] Synthesis of 1-deoxy-D-ribofuranose and its application for RNAi studies2011
- Author(s)
  Kazumi Taniho, Yoshiaki Kitamura, Yukio Kitade
- Organizer
  第38回国際核酸化学シンポジウム(ISNAC2011)
- Place of Presentation
  北海道大学(札幌)
- Year and Date
  2011-11-09
- Data Source
  KAKENHI-PROJECT-22790107
[Presentation] 塩基部欠損型ヌクレオシドを導入した2-5Aアナログの合成とその生物活性2011
- Author(s)
  谷保和美、喜多村徳昭、北出幸夫
- Organizer
  平成23年度日本薬学会東海支部例会
- Place of Presentation
  金城学院大学(名古屋)
- Year and Date
  2011-07-09
- Data Source
  KAKENHI-PROJECT-22790107
[Presentation] Synthesis of 1-deoxy-D-ribo- furanose and its application for RNAi studies2011
- Author(s)
  Kazumi Taniho、Yoshiaki Kitamura、Yukio Kitade
- Organizer
  第38回国際核酸化学シンポジウム
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22790107
[Presentation] 高機能性RNA分子の創製とその生物活性2007
- Author(s)
  北出幸夫
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜パシフィコ
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-18015021
[Presentation] 1-Deoxy-1-ethynyl-β-D-ribofuranoseの立体選択的合成
- Author(s)
  枝吉佳奈, 喜多村徳昭, 北出幸夫
- Organizer
  平成24年度日本薬学会東海支部例会
- Place of Presentation
  静岡県立大学（静岡）
- Data Source
  KAKENHI-PROJECT-22790107
[Presentation] SYNTHESIS OF OLIGONUCLEOTIDES POSSESSING ETHYNYLBENZENE GLYCOL AND THEIR APPLICATION FOR PET-LABELING
- Author(s)
  Yukio Kitade, Qin Ren, Yoshiaki Kitamura, Remi Nakashima, Aya Shibata and Masato Ikeda
- Organizer
  21st International Roundtable on Nucleosides, Nucleotides and Nucleic Acids - Chemical Biology of Nucleic Acids
- Place of Presentation
  PoznanUniversity(ポーランド）
- Year and Date
  2014-08-24 – 2014-08-28
- Data Source
  KAKENHI-PROJECT-24390025
[Presentation] Stereoselective synthesis of 1-deoxy-1-ethynyl-β-D-ribofuranose and its applications
- Author(s)
  Kana Edayoshi, Yoshiaki Kitamura, Masato Ikeda, Yukio Kitade
- Organizer
  第39回国際核酸化学シンポジウム（ISNAC2012）
- Place of Presentation
  名古屋大学（名古屋）
- Data Source
  KAKENHI-PROJECT-22790107

1. NAKANISHI Masayuki (00281048)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
2. HIROTA Kosaku (90082982)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. MAKI Yoshifumi (00082959)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. SAKO Magoichi (10137060)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. KITAMURA Yoshiaki (10503659)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
6. UENO Yoshihito (20250467)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. IKEDA Masato (20432867)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
8. AYA SHIBATA (50462693)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
9. 田中信忠 (00286866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KITADE Yukio 北出 幸夫

KITADE YUKIO 北出 幸夫

Research Projects

Research Products

Co-Researchers

Development of sophisticated small RNAs utilizing the properties of functional groups

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Owing to the development of RNA medicine, discovery of practical RNA molecules and synthesis of nucleic acid PET probesPrincipal Investigator

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Novel modification method of oligonucleotides for siRNA medicine

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がん治療を指向する高機能性マイクロRNAの開発Principal Investigator

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X線結晶構造解析を基盤とする熱帯熱マラリア原虫酵素の特異的阻害薬の開発Principal Investigator

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Development of a new generation of 2-5A-antisense and its property for the regulation of gene expression.Principal Investigator

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ゲノム情報に基づく耐性マラリアの新規化学療法薬の開発研究Principal Investigator

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ゲノム情報に基づく耐性マラリアの新規化学療法薬の開発研究Principal Investigator

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STUDY ON DRUG-DESIGN AND SYNTHESIS OF NOVEL 2-5A-ANTISENSE CHIMERASPrincipal Investigator

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組換えSAHaseを標的とするマラリア治療薬の開発研究Principal Investigator

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SAHaseの触媒機能探索と医薬品開発を指向するリード化合物の分子設計Principal Investigator

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STUDY ON CATALYTIC REACTION MECHANISM OF ADENOSYLHOMOCYSTEINE HYDRLASE AND SYNTHESIS OF THEIR MECANISM -BASED INHIBITORSPrincipal Investigator

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A New Method for the Preparation of Acyclonucleosides as a Potential Antiviral AgentsPrincipal Investigator

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KITADE Yukio 北出幸夫

KITADE YUKIO 北出幸夫