OTANI Yoshihide 大谷吉秀

Researcher Number	20168983
External Links
Affiliation (based on the past Project Information) *help	2005: Saitama Medical School, Department of Surgery, Professor, 医学部, 教授 1999 – 2004: Keio University, School of Medicine, Assistant Professor, 医学部, 専任講師 1998: 慶應義塾大学, 医学部, 助手 1994 – 1995: 慶應義塾大学, 医学部・外科学教室, 助手 1990: Keio University School of medicine, resident, 医学部, 助手 1989: 慶應義塾大学, 医学部・外科学教室, 助手 1988: 慶應義塾大学, 医学部外科学教室, 助手
Review Section/Research Field	Principal Investigator Digestive surgery / Digestive surgery / General surgery Except Principal Investigator Digestive surgery
Keywords	Principal Investigator MMP / 転移 / peritoneal dissemination / 腹膜播種 / 胃癌 / metastasis / 消化器癌 / gastric cancer / invasion / 浸潤 … More / マトリックス分解酵素 / G1 arrest / flavonoid / フラボノイド / tumor / 腫瘍 / collagen / collagenase / in situ hybridization / apoptosis / synergistic effect / 併用効果 / アポトーシス / matrix metalloproteinase / GI cancer / G1 block / MTT assay / ノビレチン / G. I. tract cancer / matrix metalloproteinased / metartasis / G.I.tract cancer / matrix metalloproteinases / Gastric cancer / extracellular matrix / mesenchymal cell / GI tract cancer / colldgen / colldgenase / Collagen / 細胞外マトリックス / 間葉系細胞 / Collagenase … More Except Principal Investigator TIMP / 3-Hydroxyproline / Type IV Collagen Degrading Enzyme / Interstitial Collagenase / Prolylhydroxylase / Collagen / Degree of Biological Malignancy / Cancer / 尿中3ーhydroxyproline / IV型コラーゲン / 基底膜 / IV型コラゲナーゼ / I型コラゲナーゼ / 胃癌 / 癌の転移 / IV型コラゲナ-ゼ / 蛋白分解酵素 / 癌の進展 / 3ーhydroxyproline / IV型コラ-ゲン分解酵素 / 間質コラゲナ-ゼ / prolylhydroxylase / コラ-ゲン / 生物学的悪性度 / 癌 Less

Establishment of novel therapeutic modalities for gastric cancer by using flavonoidPrincipal Investigator
- Principal Investigator
  
  OTANI Yoshihide
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Saitama Medical School
  Keio University
Establishment of novel therapeutic modality for peritoneal dissemination of gastric carcinoma with citrus flavonoidPrincipal Investigator
- Principal Investigator
  
  OTANI Yoshihide
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  KEIO UNIVERSITY
Nobel antimetastatic therapy by MMP inhibitor for peritoneal dissemination of gastric carcinomaPrincipal Investigator
- Principal Investigator
  
  OTANI Yoshihide
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Keio University
Antimetastatic therapy by matrix metalloproteinase inhibitorsPrincipal Investigator
- Principal Investigator
  
  OTANI Yoshihide
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Keio University
Analysis of gene expression of matrix metalloproteinases cluring the metastasis of gastrointestinal tract cancerPrincipal Investigator
- Principal Investigator
  
  OTANI Yoshihide
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Keio University
Production and Degradation of Collagen of Gastric Cancer as Determined by Histochemistry and Zymography of Cell Culture Soup
- Principal Investigator
  
  YOSHINO Keiichi
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Keio University

All 2005 2004

All Journal Article

[Journal Article] 胃癌に対する化学療法・放射線療法の現状2005
- Author(s)
  才川義朗, 吉田昌, 大谷吉秀他
- Journal Title
  
  臨床外科 60・6
  
  Pages: 735-741
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] 集学的治療により長期生存を得た腹膜播種を伴う4型胃癌の1例2005
- Author(s)
  才川義朗, 大谷吉秀他
- Journal Title
  
  胃と腸 40・7
  
  Pages: 1027-1030
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] センチネルリンパ節生検による新しい早期胃癌治療への試み2005
- Author(s)
  大谷吉秀他
- Journal Title
  
  胃と腸 40・1
  
  Pages: 112-118
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] Tyrosine kinase inhibitor SU6668 inhibits pertoneal dissemination of gastric cancer via suppression of tumor angiogenesis.2005
- Author(s)
  Tokuyama J, Kubota T, Saikawa Y, Otani Y, et al.
- Journal Title
  
  Anticancer Res 25
  
  Pages: 17-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] 集学的治療により長期生存を得た腹膜播種を伴う4型胃癌の1例2005
- Author(s)
  才川義朗, 大谷吉秀, 他
- Journal Title
  
  胃と腸 40・7
  
  Pages: 1027-30
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] 胃癌に対する化学療法・放射線療法の現状2005
- Author(s)
  才川義朗, 吉田昌, 大谷吉秀, 他
- Journal Title
  
  臨床外科 60・6
  
  Pages: 735-41
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] Tyrosine kinase inhibitor SU6668 inhibits peritoneal dissemination of gastric cancer via suppression of tumor angiogenesis.2005
- Author(s)
  Tokuyama J, Kubota T, Saikawa Y, Otani Y, et al.
- Journal Title
  
  Anticancer Res 25
  
  Pages: 17-22
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] A novel human monoclonal antibody derived from tumor-infiltrating lymphocytes in lung cancer inhibits cancer cell growth with morphological changes.2005
- Author(s)
  Aoki M, Saikawa Y, Otani Y, et al.
- Journal Title
  
  Anticancer Res 25
  
  Pages: 3791-8
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] Is chemoradiation effective or harmful for stage VI gastric cancer patients?2005
- Author(s)
  Saikawa Y, Kubota T, Otani Y, et al.
- Journal Title
  
  Oncol Rep 13・5
  
  Pages: 865-70
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] Is chemoradiation effective of harmful for stage VI gastric cancer patients?2005
- Author(s)
  Saikawa Y, Kubota T, Otani Y, et al.
- Journal Title
  
  Oncol Rep 13 (5)
  
  Pages: 865-870
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] Thymidylate synthetase (TS) genotype and TS/dihydropyrimidine dehydrogenase mRNA level as an indicator in determining chemosensitivity to 5-fluorouracil in advanced gastric carcinoma.2004
- Author(s)
  Toriumi F, Kubota T, Saikawa Y, Yoshida M, Otani Y, et al.
- Journal Title
  
  Anticancer Res 24
  
  Pages: 2455-2464
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] 消化器癌における血管新生の意義-臨床試験の現状2004
- Author(s)
  大谷吉秀, 久保田哲朗, 才川義朗, 他
- Journal Title
  
  G.I.Research 12・5
  
  Pages: 393-400
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] Anti-tumor effects of nobiletin, a citrus flavonoid, on gastric cancer include-antiproliferative effects, induction of apoptosis and cell cycle deregulation - implications for combination therapy with anticancer drugs.2004
- Author(s)
  Yoshimizu N, Otani Y, et al.
- Journal Title
  
  Aliment Pharmacol Therapeut 20(supple 1)
  
  Pages: 95-101
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] 消化器癌における血管新生の意義-臨床試験の現状-2004
- Author(s)
  大谷吉秀, 他
- Journal Title
  
  G. I. Research 12・5
  
  Pages: 393-400
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] Clinical and Pathological disappearance of peritoneal dissemination in a patient with advanced gastric cancer receiving chemotherapy with S-1 and low dose cisplatin.2004
- Author(s)
  Akatsu Y, Saikawa Y, Kubota T, Otani Y, et al.
- Journal Title
  
  Gastric Cancer 7・1
  
  Pages: 128-133
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] Differences between scirrhous and non-scirrhous human gastric carcinomas from the aspect of proMMP-2 activation regulated by TIMP-3.2004
- Author(s)
  Yokoyama T, Nakamura H, Otani Y, et al.
- Journal Title
  
  Clinical and Experimental Metastasis 21・3
  
  Pages: 223-233
- Data Source
  KAKENHI-PROJECT-16591351
[Journal Article] Docetaxel enhances the cytotoxicity of cisplatin to gastric cancer cells by modification of intracellular platinum metabolism.2004
- Author(s)
  Maeda S, Sugiura T, Saikawa Y, Kubota T, Otani Y, et al.
- Journal Title
  
  Cancer Sci 95・8
  
  Pages: 679-684
- Data Source
  KAKENHI-PROJECT-16591351

1. KAMEYAMA Kaori (10245467)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. SAKURAI Yoshiko (90245514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. YOSHINO Keiichi (10101982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. FUKASE Tatsu (90199159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. SUZUKI Fumio (50179248)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KATAI Hitoshi (20169460)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KUBOUCHI Kiyoshi (10146607)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SHIMADA Atsushi (30216056)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. MATSUI Hideo (50209483)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. AIZAWA Kenichiro (20202442)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OTANI Yoshihide 大谷 吉秀

Research Projects

Research Products

Co-Researchers

Establishment of novel therapeutic modalities for gastric cancer by using flavonoidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of novel therapeutic modality for peritoneal dissemination of gastric carcinoma with citrus flavonoidPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Nobel antimetastatic therapy by MMP inhibitor for peritoneal dissemination of gastric carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Antimetastatic therapy by matrix metalloproteinase inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of gene expression of matrix metalloproteinases cluring the metastasis of gastrointestinal tract cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Production and Degradation of Collagen of Gastric Cancer as Determined by Histochemistry and Zymography of Cell Culture Soup

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 胃癌に対する化学療法・放射線療法の現状2005

Author(s)

Journal Title

Data Source

[Journal Article] 集学的治療により長期生存を得た腹膜播種を伴う4型胃癌の1例2005

Author(s)

Journal Title

Data Source

[Journal Article] センチネルリンパ節生検による新しい早期胃癌治療への試み2005

Author(s)

Journal Title

Data Source

[Journal Article] Tyrosine kinase inhibitor SU6668 inhibits pertoneal dissemination of gastric cancer via suppression of tumor angiogenesis.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] 集学的治療により長期生存を得た腹膜播種を伴う4型胃癌の1例2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] 胃癌に対する化学療法・放射線療法の現状2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Tyrosine kinase inhibitor SU6668 inhibits peritoneal dissemination of gastric cancer via suppression of tumor angiogenesis.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] A novel human monoclonal antibody derived from tumor-infiltrating lymphocytes in lung cancer inhibits cancer cell growth with morphological changes.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Is chemoradiation effective or harmful for stage VI gastric cancer patients?2005

Author(s)

Journal Title

OTANI Yoshihide 大谷吉秀