KOMATSU Takayuki 小松孝行

… Alternative Names

小松孝行コマツタカユキ

小松孝幸コマツタカユキ

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Researcher Number	20215388
Other IDs
External Links
Affiliation (Current)	2025: 愛知医科大学, 愛知医科大学, 客員教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 愛知医科大学, 医学部, 教授 2017 – 2021: 愛知医科大学, 医学部, 准教授 2008: 愛知医科大学, 医学部, 講師 2003 – 2005: University of Fukui, Faculty of Medical Sciences, Associate Professor, 医学部, 助手 2001 – 2002: 福井医科大学, 医学部, 助手 1992: 福井医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 54030:Infectious disease medicine-related / Virology Except Principal Investigator Biological Sciences / Basic Section 54030:Infectious disease medicine-related / Virology / Virology / 内分泌・代謝学
Keywords	Principal Investigator 自然免疫 / アクセサリー蛋白質 / インターフェロン / メタニューモウイルス / パラインフルエンザウイルス / インフラマソーム / パラミクソウイルス / MAVS / TRIM25 / RIG-I … More / RSウイルス / モノネガウイルス / ニューモウイルス / 抗ウイルス薬 / ワクチン / ウイルス / NLRP3インフラマソーム / IL-1β … More Except Principal Investigator インターフェロン / C蛋白質 / アクセサリー蛋白質 / STAT1 / センダイウイルス / 免疫回避 / STATs / 自然免疫 / シグナル伝達 / パラミクソウイルス / STAT2 / ヒトメタニューモウイルス / V蛋白質 / パラインフルエンザウイルス / 生ワクチン / 抗インターフェロン / TLR7/9 / RIG-I / phosphorylation / signaling / Interferon / accessory proteins / C protein / Sendai virus / GAS / GAF / リン酸化 / インターフィロン / ウイルス / pDC / 9 / TLR7 / 呼吸器感染症 / M2-2 / Toll-like receptor / IRF7 / 免疫応答 / 病原性 / 脱リン酸化 / STAT / PKR / MDA5 / 抗インターフェロン蛋白質 / NF-κB / IRF-3 / インターフェロン産生 / リンパ球抗原 / NODマウス / p120 / 糖尿 / 糖尿病 / Insulitis / NOD Less

モノネガウイルスに保存された抗インターフェロン機構の解明と治療薬の研究Principal Investigator
- Principal Investigator
  
  小松孝行
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Aichi Medical University
抗インターフェロン能を欠失させた新規ヒトメタニューモウイルスワクチンの研究
- Principal Investigator
  
  田中幸枝
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  University of Fukui
Study on new vaccine and therapy using the parmyxovirus lacking inflammasome antagonismPrincipal Investigator
- Principal Investigator
  
  Komatsu Takayuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  Aichi Medical University
Is inflammasome antagonism of the paramyxovirus V protein important for the pathogenicity ?Principal Investigator
- Principal Investigator
  
  KOMATSU Takayuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Aichi Medical University
Human metapneumovirus pathogenicity and its interferon antagonism
- Principal Investigator
  
  GOTOH Bin
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Shiga University of Medical Science
パラインフルエンザウイルスの抗インターフェロン蛋白質
- Principal Investigator
  
  後藤敏
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Fukui
パラインフルエンザウイルスのインターフェロン産生制御機構
- Principal Investigator
  
  後藤敏
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  福井医科大学
パラミクソウイルスの自然免疫回避機構
- Principal Investigator
  
  後藤敏
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  福井医科大学
パラミクソウイルスの自然免疫回避機構
- Principal Investigator
  
  GOTOH Bin
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  福井医科大学
Mechanism by which Sendai virus inhibits interferon signaling
- Principal Investigator
  
  GOTOH Bin
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  福井医科大学
I型糖尿病モデル動物であるNODマウスに特異的に発現しているリンパ球抗原
- Principal Investigator
  
  海藤敏雄
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Fukui Prefectural University
  Hamamatsu University School of Medicine

All 2022 2021 2020 2019 2018 2008 2007 2006 2004

All Journal Article Presentation

[Journal Article] SeV C Protein Plays a Role in Restricting Macrophage Phagocytosis by Limiting the Generation of Intracellular Double-Stranded RNA2022
- Author(s)
  Morita Naoko、Tanaka Yukie、Takeuchi Kenji、Kitagawa Yoshinori、Sakuma Ryusuke、Koide Naoki、Komatsu Takayuki
- Journal Title
  
  Frontiers in Microbiology
  
  Volume: 13 Pages: 1-13
- DOI
  10.3389/fmicb.2022.780534
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07354, KAKENHI-PROJECT-20K08830, KAKENHI-PROJECT-20K17463, KAKENHI-PROJECT-20K17474, KAKENHI-PROJECT-20K08838
[Journal Article] Sendai virus C protein affects macrophage function, which plays a critical role in modulating disease severity during Sendai virus infection in mice2022
- Author(s)
  Sakuma R, Morita N, Tanaka Y, Koide N, Komatsu T（責任著者）.
- Journal Title
  
  Microbiol Immunol.
  
  Volume: 66 Issue: 3 Pages: 124-134
- DOI
  10.1111/1348-0421.12956
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08830, KAKENHI-PROJECT-20K17463, KAKENHI-PROJECT-20K17474
[Journal Article] Human metapneumovirus M2-2 protein inhibits RIG-I signaling by preventing TRIM25-mediated RIG-I ubiquitination2022
- Author(s)
  Tanaka Y, Morita N, Kitagawa Y, Bin Gotoh, Komatsu T（責任著者）.
- Journal Title
  
  Front Immunol.
  
  Volume: 22 Pages: 1-15
- DOI
  10.3389/fimmu.2022.970750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08830, KAKENHI-PROJECT-20K17463, KAKENHI-PROJECT-20K17474, KAKENHI-PROJECT-20K08838
[Journal Article] Sendai virus V protein decreases nitric oxide production by inhibiting RIG-I signaling in infected RAW264.7 macrophages.2020
- Author(s)
  Morita N, Tanaka Y, Odkhuu E, Naiki Y, Komatsu T, Koide N.
- Journal Title
  
  Microbes Infect.
  
  Volume: - Issue: 8 Pages: 322-330
- DOI
  10.1016/j.micinf.2020.01.005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08866, KAKENHI-PROJECT-20K08830, KAKENHI-PROJECT-20K17463, KAKENHI-PROJECT-20K17474
[Journal Article] Eligibility of Feline Calicivirus for a Surrogate of Human Norovirus in Comparison with Murine Norovirus, Poliovirus and Coxsackievirus2018
- Author(s)
  OHMINE TAKAHITO、NARAI SEIKA、MATSUBARA TOSHIKI、NOMURA TOSHIHITO、ODA KOSUKE、FUKUSHI MASAYA、IRIE TAKASHI、KOMATSU TAKAYUKI、TOHYA YUKINOBU、SAKAGUCHI TAKEMASA
- Journal Title
  
  Biocontrol Science
  
  Volume: 23 Issue: 3 Pages: 145-149
- DOI
  10.4265/bio.23.145
- NAID
  130007485669
- ISSN
  1342-4815, 1884-0205
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08866, KAKENHI-PROJECT-17K19560, KAKENHI-PROJECT-16H05197
[Journal Article] NF-κB inhibitor DHMEQ inhibits titanium dioxide nanoparticle-induced interleukin-1β production: Inhibition of the PM2.5-induced inflammation model.2018
- Author(s)
  Fukatsu H, Koide N, Tada-Oikawa S, Izuoka K, Ikegami A, Ichihara S, Ukaji T, Morita N, Naiki Y, Komatsu T, Umezawa K.
- Journal Title
  
  Mol Med Rep
  
  Volume: 18 Pages: 5279-5285
- DOI
  10.3892/mmr.2018.9533
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K00937, KAKENHI-PROJECT-17K01967, KAKENHI-PROJECT-17K08866, KAKENHI-PROJECT-26305023
[Journal Article] Sendai virus C protein limits NO production in infected RAW264.7 macrophages2018
- Author(s)
  Odkhuu Erdenezaya、Komatsu Takayuki、Koide Naoki、Naiki Yoshikazu、Takeuchi Kenji、Tanaka Yukie、Tsolmongyn Bilegtsaikhan、Jambalganiin Ulziisaikhan、Morita Naoko、Yoshida Tomoaki、Gotoh Bin、Yokochi Takashi
- Journal Title
  
  Innate Immunity
  
  Volume: 24 Issue: 7 Pages: 430-438
- DOI
  10.1177/1753425918796619
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08866
[Journal Article] Sendai Virus V Protein Inhibits the Secretion of Interleukin-1β by Preventing NLRP3 Inflammasome Assembly2018
- Author(s)
  Komatsu Takayuki、Tanaka Yukie、Kitagawa Yoshinori、Koide Naoki、Naiki Yoshikazu、Morita Naoko、Gotoh Bin、Yokochi Takashi
- Journal Title
  
  Journal of Virology
  
  Volume: 92 Issue: 19
- DOI
  10.1128/jvi.00842-18
- NAID
  120006694166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08866
[Journal Article] Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA2008
- Author(s)
  Kenji Takeuchi, Takayuki Komatsu, Yoshinori Kitagawa, Kiyonao Sada, Bin Gotoh
- Journal Title
  
  Journal of Virology 82(20)
  
  Pages: 10102-10110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590446
[Journal Article] Bovine parainfluenza virus type 3 accessory proteins that suppress betainterferonproduction2007
- Author(s)
  Takayuki Komatsu
- Journal Title
  
  Microbes and Infection 9
  
  Pages: 954-962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590446
[Journal Article] Bovine parainfluenza virus type 3 accessory proteins that suppress beta interferon production2007
- Author(s)
  Takayuki Komatsu, Kenji Takeuchi, Bin Gotoh
- Journal Title
  
  Microbes and Infection 9(8)
  
  Pages: 954-962
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590446
[Journal Article] C and V proteins of Sendai virus target signaling pathways leading to IRF-3 activation for the negative regulation of interferon-β production2004
- Author(s)
  Komatsu, T.
- Journal Title
  
  Virology 325
  
  Pages: 137-148
- Data Source
  KAKENHI-PROJECT-16017236
[Presentation] ヒトメタニューモウイルスM2-2蛋白質のインターフェロン-βシグナル抑制機構.2022
- Author(s)
  田中幸枝，森田奈央子，小松孝行
- Organizer
  細菌学会中部支部総会（金沢）
- Data Source
  KAKENHI-PROJECT-20K08830
[Presentation] Human metapneumovirus M2-2 protein inhibits RIG-I signaling by preventing TRIM25-mediated RIG-I ubiquitination.2022
- Author(s)
  Tanaka Y, Morita N, Kitagawa Y, Gotoh B, Komatsu T.
- Organizer
  The 70 th Annual Meeting of the Japanese Society for Virology
- Data Source
  KAKENHI-PROJECT-20K08830
[Presentation] センダイウイルスV蛋白質はRIG-Iシグナルを阻害することで一酸化窒素の産生を抑制する2021
- Author(s)
  森田奈央子，田中幸枝，小松孝行
- Organizer
  日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-20K08830
[Presentation] C gene knockout Sendai virus activates the phagocytosis in infected RAW264.7 macrophages.2019
- Author(s)
  Morita N, Tanaka Y, Takeuchi K, Naiki Y, Koide N, Komatsu T.
- Organizer
  The 67th Annual Meeting of the Japanese Society of Virology. Oct.29-31, 2019, Tokyo.
- Data Source
  KAKENHI-PROJECT-17K08866
[Presentation] C gene knockout Sendai virus induces the secretion of IL-1β by facilitating NLRP3 inflammasome assembly2019
- Author(s)
  Komatsu T, Tanaka Y, Takeuchi K, Morita N, Naiki Y, Koide N.
- Organizer
  The 67th Annual Meeting of the Japanese Society of Virology. Oct.29-31, 2019, Tokyo.
- Data Source
  KAKENHI-PROJECT-17K08866
[Presentation] パラミクソウイルのNLRP3インフラマソーム抑制機構の解析2019
- Author(s)
  小松孝行，内記良一，森田奈央子，小出直樹
- Organizer
  第48回　東海乳酸菌研究会　研究報告会
- Data Source
  KAKENHI-PROJECT-17K08866
[Presentation] Inflammasome antagonism by murine parainfluenza virus type1 V protein.2019
- Author(s)
  Tanaka Y, Komatsu T, Morita N, Naiki Y, Koide N.
- Organizer
  The 84rd Annual Meeting of the Japanese Society of Interferon & Cytokine Research
- Data Source
  KAKENHI-PROJECT-17K08866
[Presentation] V gene knockout Sendai virus induces the secretion of IL-1β by facilitating NLRP3 inflammasome assembly.2018
- Author(s)
  Komatsu T, Tanaka Y, Morita N, Naiki Y, Koide N.
- Organizer
  The 66th Annual Meeting of the Japanese Society for Virology. Oct. 28-30, 2018 Kyoto.
- Data Source
  KAKENHI-PROJECT-17K08866
[Presentation] Knockout of the Sendai virus V gene reduces the viral ability to prevent the macrophage phagocytosis.2018
- Author(s)
  Morita N, Tanaka Y, Takeuchi K, Naiki Y, Koide N, Komatsu T.
- Organizer
  The 66th Annual Meeting of the Japanese Society for Virology. Oct. 28-30, 2018 Kyoto.
- Data Source
  KAKENHI-PROJECT-17K08866
[Presentation] ヒトメタニューモウイルスゲノムCdnaからのウイルス回収系2008
- Author(s)
  周敏、北川善紀、山口まゆ、小松孝行、竹内健司、伊藤正恵、後藤敏
- Organizer
  第56回日本ウイルス学会学術集会
- Place of Presentation
  岡山
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-18590446
[Presentation] センダイウイルスC蛋白質の新しい役割 : 二重鎖RNA生成の抑制2008
- Author(s)
  竹内健司、小松孝行、北川善紀、定清直、後藤敏
- Organizer
  第56回日本ウイルス学会学術集会
- Place of Presentation
  岡山
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-18590446
[Presentation] ヒトメタニューモウイルスミニゲノム系を利用したM2-2蛋白質の転写複製調節の解析2008
- Author(s)
  北川善紀、山口まゆ、周敏、小松孝行、竹内健司、西尾真智子、伊藤正恵、後藤敏
- Organizer
  第56回日本ウイルス学会学術集会
- Place of Presentation
  岡山
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-18590446
[Presentation] ニパウイルスと局所感染型パラミクソウイルスのTLR7/9経路阻害能2008
- Author(s)
  北川善紀、山口まゆ、周敏、小松孝行、竹内健司、西尾真智子、伊藤正恵、後藤敏
- Organizer
  第56回日本ウイルス学会学術集会
- Place of Presentation
  岡山
- Year and Date
  2008-10-26
- Data Source
  KAKENHI-PROJECT-18590446
[Presentation] ヒトメタニューモウイルスの宿主IFN-α産生シグナル阻害機構2007
- Author(s)
  北川善紀、小松孝行、竹内健司、周敏、伊藤正恵、後藤敏
- Organizer
  第55回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2007-10-22
- Data Source
  KAKENHI-PROJECT-18590446
[Presentation] ヒトRSウイルスとTLR7/9依存性IFN-α産生シグナル2007
- Author(s)
  小松孝行、竹内健司、北川善紀、定清直、後藤敏
- Organizer
  第55回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2007-10-23
- Data Source
  KAKENHI-PROJECT-18590446
[Presentation] RSウイルスのインターフェロンアンタゴニズム2006
- Author(s)
  小松孝行、竹内健司、後藤敏
- Organizer
  第54回日本ウイルス学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2006-10-20
- Data Source
  KAKENHI-PROJECT-18590446
[Presentation] センダイウイルスのインターフェロン抵抗性:第三の機構2006
- Author(s)
  竹内健司、小松孝行、後藤敏
- Organizer
  第54回日本ウイルス学会学術集会
- Place of Presentation
  名古ろ屋
- Year and Date
  2006-10-20
- Data Source
  KAKENHI-PROJECT-18590446
[Presentation] ヒトメタニューモウイルスとインターフェロン対抗能2006
- Author(s)
  後藤敏、小松孝行、竹内健司、北川善紀
- Organizer
  第54回日本ウイルス学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2006-10-21
- Data Source
  KAKENHI-PROJECT-18590446

1. GOTOH Bin (00211920)

# of Collaborated Projects: 6 results

# of Collaborated Products: 11 results
2. TAKEUCHI Kenji (40236419)

# of Collaborated Projects: 6 results

# of Collaborated Products: 12 results
3. 田中幸枝 (10197486)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
4. 森田奈央子 (20815881)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
5. KITAGAWA Yoshinori (00444448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
6. 海藤敏雄 (80185701)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 小出幸夫 (30126809)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OIKAWA Saeko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOMATSU Takayuki 小松 孝行

小松 孝行 コマツ タカユキ

小松 孝幸 コマツ タカユキ

Research Projects

Research Products

Co-Researchers

モノネガウイルスに保存された抗インターフェロン機構の解明と治療薬の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

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Study on new vaccine and therapy using the parmyxovirus lacking inflammasome antagonismPrincipal Investigator

Principal Investigator

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Review Section

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Is inflammasome antagonism of the paramyxovirus V protein important for the pathogenicity ?Principal Investigator

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Principal Investigator

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Principal Investigator

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Principal Investigator

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Principal Investigator

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Principal Investigator

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[Journal Article] SeV C Protein Plays a Role in Restricting Macrophage Phagocytosis by Limiting the Generation of Intracellular Double-Stranded RNA2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sendai virus C protein affects macrophage function, which plays a critical role in modulating disease severity during Sendai virus infection in mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human metapneumovirus M2-2 protein inhibits RIG-I signaling by preventing TRIM25-mediated RIG-I ubiquitination2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sendai virus V protein decreases nitric oxide production by inhibiting RIG-I signaling in infected RAW264.7 macrophages.2020

KOMATSU Takayuki 小松孝行

小松孝行コマツタカユキ

小松孝幸コマツタカユキ

[Presentation] ヒトメタニューモウイルスM2-2蛋白質のインターフェロン-βシグナル抑制機構.2022