Igarashi Hironaka 五十嵐博中

… Alternative Names

IGARASHI Hironaka 五十嵐博中

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Researcher Number	20231128
Other IDs
Affiliation (Current)	2025: 新潟大学, 脳研究所, 教授
Affiliation (based on the past Project Information) *help	2011 – 2025: 新潟大学, 脳研究所, 教授 2010: 新潟大学, 脳研究所, 准教授 2009: 新潟大学, 脳研究所, 教授 2007 – 2008: 新潟大学, 脳研究所, 准教授 2000 – 2002: 日本医科大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Medium-sized Section 52:General internal medicine and related fields / Basic Section 52040:Radiological sciences-related / Radiation science / Neurology / Neurology Except Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Basic Section 52020:Neurology-related / Neurology / Basic Section 56010:Neurosurgery-related / Medium-sized Section 52:General internal medicine and related fields / Rehabilitation science/Welfare engineering / Neuroscience in general
Keywords	Principal Investigator MRI / CEST / CMRO2 / NMR / MRS / 脳虚血 / 磁気共鳴学 / 神経機能画像学 / 創薬 / 治療 … More / アクアポリン4 / 水頭症 / 脳浮腫 / グリンファティック・システム / 認知予備脳 / シナプス / 認知予備能 / アルツハイマー病 / 磁気共鳴イメージング / 薬剤モニタリング / brain metabolism / CMRglu / rCBV / rCBF / 糖代謝 / 13C / coupling / CMRGLU / 脳代謝 / 脳循環 / 脳血液量 / 脳酸素消費量 / 脳血流量 / 出血性梗塞 / 19F … More Except Principal Investigator 体性感覚過敏 / 視覚過敏 / PPPD / 持続性知覚性姿勢誘発めまい / 視神経脊髄炎 / 多発性硬化症 / VEGF / 血栓溶解療法 / ラット / 脳虚血 / 顆粒球 / 好中球 / 細胞外DNAトラップ / 病態 / 7T-MRI / 微小環境 / 組織透明化 / グリオーマ / 新規治療法開発 / 摘出脳組織透明化 / 3次元病理解析 / 7T-MRI詳細画像 / 腫瘍微小環境 / 脳機能画像 / 感覚代行 / 検査 / 前庭 / 体性感覚 / 視覚 / めまい / 認知症 / リンパ管 / 脳小血管 / 脳小血管病 / フィブロネクチン / 細胞外基質 / カンデサルタン / 血管 / 老化 / neural repair / IEL / 腸内細菌叢 / マウス / 腸管上皮細胞 / 脳梗塞モデル / distal MCA / 脳梗塞 / 抗生物質 / 腸内細菌 / mice / ischemic stroke / gut microbiota / 血液脳関門 / t-PA / 神経分子病態学 / 超候磁場 / magnetic resonance spectroscopy / 機能画像 / hyperpolarization / MR spectroscopy / 超高磁場 / 解剖学的解像度 / MR microscopy / 7テスラ / MRI / 脳・神経 / 抗体療法 / 血管内皮細胞増殖因子 / 組織型プラスミノゲン・アクチベーター / 神経病態薬理学・脳虚血 Less

筋委縮性側索硬化症における多層的MRIバイオマーカーによる早期診断と病態進行可視化Principal Investigator
- Principal Investigator
  
  五十嵐博中
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Niigata University
持続性知覚性姿勢誘発めまい：客観的診断法と病態に基づく新規治療法の開発
- Principal Investigator
  
  堀井新
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Niigata University
自己免疫性グリア病における免疫細胞由来「細胞外DNAトラップ」の生物学的意義の解明
- Principal Investigator
  
  河内泉
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Niigata University
PPPD: diagnostic test batteries and novel treatment strategy based on pathophysiology
- Principal Investigator
  
  Horii Arata
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Niigata University
Visualization of microenvironments of malignant glioma utilizing 7T-MRI and 3D tissue clearing technology
- Principal Investigator
  
  Fujii Yukihiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Niigata University
Spatiotemporal dynamics of immune cells with ability of neural repair in the CNS of autoimmune gliopathy
- Principal Investigator
  
  Kawachi Izumi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Niigata University
Development of a Novel Treatment for Normal Pressure Hydrocephalus with an Aquaporin-4 ModulatorPrincipal Investigator
- Principal Investigator
  
  Igarashi Hironaka
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Niigata University
Approach to neurodegenerative disorders by elucidation of the excretion pathway of the brain.
- Principal Investigator
  
  ONODERA OSMAU
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Niigata University
Development of a method to assess cognitive reserve in Alzheimer's disease using chemical exchange saturation transfer MRI.Principal Investigator
- Principal Investigator
  
  Igarashi Hironaka
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Niigata University
Effects of Gut Microbiota Regulation on Cerebral Ischemic Lesion Expansion and Neurological Function
- Principal Investigator
  
  Nishiyama Yasuhiro
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Nippon Medical School
Development of in vivo drug monitoring precedure using CESt MRIPrincipal Investigator
- Principal Investigator
  
  Igarashi Hironaka
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Niigata University
Development of MMP specific 19F-MRS tracer to assess the disruption of neuro vascular unit in brainPrincipal Investigator
- Principal Investigator
  
  Igarashi Hironaka
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Magnetic Resonance Molecular Microimaging
- Principal Investigator
  
  NAKADA Tsutomu
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Neuroscience in general
- Research Institution
  Niigata University
Establishment of selective VEGF inhibition treatment as a novel therapeutic strategy against ischemic stroke
- Principal Investigator
  
  SHIMOHATA Takayoshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Analysis of the neurovascular protection by the novel therapeutic agent, Bevacizumab
- Principal Investigator
  
  SHIMOHATA Takayoshi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Energy source in brain activation monitored by nuclear magnetic resonancePrincipal Investigator
- Principal Investigator
  
  IGARASHI Hironaka
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Nippon Medical School

[Book] 小脳と運動失調、小脳はなにをしているのか2013
- Author(s)
  五十嵐　博中(分担)、西澤正豊（編）
- Total Pages
  336
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-25461310
[Book] 小脳と運動失調、小脳はなにをしているのか2013
- Author(s)
  西澤正豊、五十嵐　博中(分担)
- Total Pages
  336
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-21220007
[Book] 磁気共鳴スペクトルの医学応用2012
- Author(s)
  五十嵐　博中（分担）
- Total Pages
  300
- Publisher
  インナービジョン
- Data Source
  KAKENHI-PROJECT-21220007
[Journal Article] Stage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: a role for netting neutrophils with resident memory T cells in situ2024
- Author(s)
  Nakajima A, Yanagimura F, Saji E, Shimizu H, Toyoshima Y, Yanagawa K, Arakawa M, Hokari M, Yokoseki A, Wakasugi T, Okamoto K, Takebayashi H, Fujii C, Itoh K, Takei YI, Ohara S, Yamada M, Takahashi H, Nishizawa M, Igarashi H, Kakita A, Onodera O, Kawachi I.
- Journal Title
  
  Acta Neuropathologica
  
  Volume: 147 Issue: 1 Pages: 76-76
- DOI
  10.1007/s00401-024-02725-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K06923, KAKENHI-PROJECT-21K07412
[Journal Article] Changes in functional connectivity among vestibulo-visuo-somatosensory and spatial cognitive cortical areas in persistent postural-perceptual dizziness: resting-state fMRI studies before and after visual stimulation2023
- Author(s)
  Yagi Chihiro、Morita Yuka、Yamagishi Tatsuya、Ohshima Shinsuke、Izumi Shuji、Takahashi Kuniyuki、Watanabe Masaki、Itoh Kosuke、Suzuki Yuji、Igarashi Hironaka、Horii Arata
- Journal Title
  
  Frontiers in Neurology
  
  Volume: 14 Pages: 1215004-1215004
- DOI
  10.3389/fneur.2023.1215004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20514, KAKENHI-PROJECT-23K08979, KAKENHI-PROJECT-21H03084
[Journal Article] Gaze instability after exposure to moving visual stimuli in patients with persistent postural-perceptual dizziness2022
- Author(s)
  Yagi Chihiro、Morita Yuka、Yamagishi Tatsuya、Ohshima Shinsuke、Izumi Shuji、Takahashi Kuniyuki、Itoh Kosuke、Suzuki Yuji、Igarashi Hironaka、Horii Arata
- Journal Title
  
  Frontiers in Human Neuroscience
  
  Volume: 16 Pages: 1056556-1056556
- DOI
  10.3389/fnhum.2022.1056556
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20514, KAKENHI-PROJECT-18H02762, KAKENHI-PROJECT-21H03084, KAKENHI-PROJECT-19K18799
[Journal Article] Correction to: JNK1?Dependent Phosphorylation of GAP?43 Serine 142 is a Novel Molecular Marker for Axonal Growth2022
- Author(s)
  Okada Masayasu、Kawagoe Yosuke、Takasugi Toshiyuki、Nozumi Motohiro、Ito Yasuyuki、Fukusumi Hayato、Kanemura Yonehiro、Fujii Yukihiko、Igarashi Michihiro
- Journal Title
  
  Neurochemical Research
  
  Volume: 47 Issue: 9 Pages: 2683-2683
- DOI
  10.1007/s11064-022-03639-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H03042
[Journal Article] Cerebral cortical processing time is elongated in human brain evolution2022
- Author(s)
  Itoh Kosuke、Konoike Naho、Nejime Masafumi、Iwaoki Haruhiko、Igarashi Hironaka、Hirata Satoshi、Nakamura Katsuki
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 1103-1103
- DOI
  10.1038/s41598-022-05053-w
- NAID
  120007185936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02762, KAKENHI-PUBLICLY-21H00304, KAKENHI-PLANNED-18H05524, KAKENHI-PROJECT-23K21414
[Journal Article] SWI by 7T MR Imaging for the Microscopic Imaging Diagnosis of Astrocytic and Oligodendroglial Tumors2022
- Author(s)
  Natsumeda M.、Matsuzawa H.、Watanabe M.、Motohashi K.、Gabdulkhaev R.、Tsukamoto Y.、Kanemaru Y.、Watanabe J.、Ogura R.、Okada M.、Kurabe S.、Okamoto K.、Kakita A.、Igarashi H.、Fujii Y.
- Journal Title
  
  American Journal of Neuroradiology
  
  Volume: 43 Issue: 11 Pages: 1575-1581
- DOI
  10.3174/ajnr.a7666
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K20514, KAKENHI-PROJECT-18H02762, KAKENHI-PROJECT-21H03042
[Journal Article] JNK1-Dependent Phosphorylation of GAP-43 Serine 142 is a Novel Molecular Marker for Axonal Growth2022
- Author(s)
  Okada M, Kawagoe Y, Takasugi T, Nozumi M, Ito Y, Fukusumi H, Kanemura Y, Fujii Y, Igarashi M.
- Journal Title
  
  Neurochem Res
  
  Volume: 印刷中 Issue: 9 Pages: 2668-2682
- DOI
  10.1007/s11064-022-03580-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10888, KAKENHI-PROJECT-17KK0144, KAKENHI-PROJECT-18H04013, KAKENHI-PROJECT-21K19305, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-21H03042
[Journal Article] GlyCEST: Magnetic Resonance Imaging of Glycine - Distribution in the Normal Murine Brain and Alterations in 5xFAD Mice2021
- Author(s)
  Ken Ohno,Masaki Ohkubo, Bingwen Zheng, Masaki Watanabe, Tsuyoshi Matsuda, Ingrid L. Kwee, Hironaka Igarashi
- Journal Title
  
  Contrast Media & Molecular Imaging
  
  Volume: eCollection Pages: 8988762-8988762
- DOI
  10.1155/2021/8988762
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02762, KAKENHI-PROJECT-20K16774
[Journal Article] Visual outcome of aquaporin-4 antibody-positive optic neuritis with maintenance therapy.2021
- Author(s)
  Ueki S, Hatase T, Kiyokawa M, Kawachi I, Saji E, Onodera O, Fukuchi T, Igarashi H.
- Journal Title
  
  Jpn J Ophthalmol.
  
  Volume: 65 Issue: 5 Pages: 699-703
- DOI
  10.1007/s10384-021-00858-0
- NAID
  40022680433
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09399, KAKENHI-PROJECT-20K07899, KAKENHI-PROJECT-21K07412
[Journal Article] Candesartan prevents arteriopathy progression in cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy model2021
- Author(s)
  Kato T, Manabe RI, Igarashi H, Kametani F, Hirokawa S, Sekine Y, Fujita N, Saito S, Kawashima Y, Hatano Y, Ando S, Nozaki H, Sugai A, Uemura M, Fukunaga M, Sato T, Koyama A, Saito R, Sugie A, Toyoshima Y, Kawata H, Murayama S, Matsumoto M, Kakita A, Hasegawa M, Ihara M, Kanazawa M, Nishizawa M, Tsuji S, Onodera O.
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 131 Issue: 22
- DOI
  10.1172/jci140555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-20H05930, KAKENHI-PROJECT-19H01043, KAKENHI-PROJECT-20K21386, KAKENHI-PROJECT-16H06280, KAKENHI-PROJECT-20K07880
[Journal Article] Longitudinal GluCEST MRI Changes and Cerebral Blood Flow in 5xFAD Mice2020
- Author(s)
  Igarashi Hironaka、Ueki Satoshi、Kitaura Hiroki、Kera Tae、Ohno Ken、Ohkubo Masaki、Terumitsu-Tsujita Mika、Kakita Akiyoshi、Kwee Ingrid L
- Journal Title
  
  Contrast Media & Molecular Imaging
  
  Volume: 2020 Pages: 1-12
- DOI
  10.1155/2020/8831936
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16774, KAKENHI-PROJECT-18H02762, KAKENHI-PROJECT-19H03542
[Journal Article] Vascular Hyperintensity on Fluid-Attenuated Inversion Recovery Indicates the Severity of Hypoperfusion in Acute Stroke2020
- Author(s)
  Nomura Toshiharu、Okamoto Kouichirou、Igarashi Hironaka、Watanabe Masato、Hasegawa Hitoshi、Oishi Makoto、Fujii Yukihiko
- Journal Title
  
  Journal of Stroke and Cerebrovascular Diseases
  
  Volume: 29 Issue: 2 Pages: 104467-104467
- DOI
  10.1016/j.jstrokecerebrovasdis.2019.104467
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02762, KAKENHI-PROJECT-17K10888
[Journal Article] Auditory T-Complex Reveals Reduced Neural Activities in the Right Auditory Cortex in Musicians With Absolute Pitch2019
- Author(s)
  Matsuda Masato、Igarashi Hironaka、Itoh Kosuke
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 13 Pages: 1-1
- DOI
  10.3389/fnins.2019.00809
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-19H05309, KAKENHI-PROJECT-18H02762, KAKENHI-PROJECT-17K00202, KAKENHI-PROJECT-19H01770
[Journal Article] Automaticity of pitch class-color synesthesia as revealed by a Stroop-like effect2019
- Author(s)
  Itoh Kosuke、Sakata Honami、Igarashi Hironaka、Nakada Tsutomu
- Journal Title
  
  Consciousness and Cognition
  
  Volume: 71 Pages: 86-91
- DOI
  10.1016/j.concog.2019.04.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H02762, KAKENHI-PROJECT-19H01770
[Journal Article] Visualizing the Distribution of Matrix Metalloproteinases in Ischemic Brain Using In Vivo 19F-Magnetic Resonance Spectroscopic Imaging2019
- Author(s)
  Huber Vincent J.、Igarashi Hironaka、Ueki Satoshi、Terumitsu-Tsujita Mika、Nito Chikako、Ohno Ken、Suzuki Yuji、Itoh Kosuke、Kwee Ingrid L.、Nakada Tsutomu
- Journal Title
  
  Contrast Media & Molecular Imaging
  
  Volume: 2019 Pages: 1-8
- DOI
  10.1155/2019/8908943
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02762, KAKENHI-PROJECT-16K15574, KAKENHI-PROJECT-16K15643, KAKENHI-PROJECT-17H02191
[Journal Article] Aquaporin-4 facilitator TGN-073 promotes interstitial fluid circulation within the blood?brain barrier2018
- Author(s)
  Huber Vincent J.、Igarashi Hironaka、Ueki Satoshi、Kwee Ingrid L.、Nakada Tsutomu
- Journal Title
  
  NeuroReport
  
  Volume: 29 Issue: 9 Pages: 697-703
- DOI
  10.1097/wnr.0000000000000990
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02762, KAKENHI-PROJECT-16K15574
[Journal Article] Reliable diagnosis of IDH-mutant glioblastoma by 2-hydroxyglutarate detection: a study by 3-T magnetic resonance spectroscopy.2018
- Author(s)
  Natsumeda M, Motohashi K, Igarashi H, Nozawa T, Abe H, Tsukamoto Y, Ogura R, Okada M, Kobayashi T, Aoki H, Takahashi H, Kakita A, Okamoto K, Nakada T, Fujii Y.
- Journal Title
  
  Neurosurg Rev
  
  Volume: 41 Issue: 2 Pages: 641-647
- DOI
  10.1007/s10143-017-0908-y
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10888, KAKENHI-PROJECT-17K16632, KAKENHI-PROJECT-18H02762, KAKENHI-PROJECT-16K15574
[Journal Article] Sleep Apnea in Multiple System Atrophy of Cerebellar Type: A 3.0 T MRS/Volumetry Pilot Study2017
- Author(s)
  Takado Y, Terajima K, Shimohata T, Nakayama H, Watanabe M, Okamoto K, Ozawa T, Nishizawa M, Kwee IL, Igarashi H, .Nakada T
- Journal Title
  
  eNeurologicalSci
  
  Volume: 6 Pages: 6-8
- DOI
  10.1016/j.ensci.2016.10.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15574
[Journal Article] Slow Accumulations of Neural Activities in Multiple Cortical Regions Precede Self-Initiation of Movement: An Event-Related fMRI Study2017
- Author(s)
  Sakata H, Itoh K, Suzuki Y, Nakamura K, Watanabe M, Igarashi H, Nakada T.
- Journal Title
  
  eNeuro.
  
  Volume: 4 Issue: 5 Pages: ENEURO.0183-17.2017
- DOI
  10.1523/eneuro.0183-17.2017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15574
[Journal Article] Aquaporin-4 Functionality and Virchow-Robin Space Water Dynamics: Physiological Model for Neurovascular Coupling and Glymphatic Flow2017
- Author(s)
  Nakada Tsutomu、Kwee Ingrid、Igarashi Hironaka、Suzuki Yuji
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 18 Issue: 8 Pages: 1798-1798
- DOI
  10.3390/ijms18081798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15574, KAKENHI-PROJECT-16K15643, KAKENHI-PROJECT-17H02191
[Journal Article] Maturational decrease of glutamate in the human cerebral cortex from childhood to young adulthood: A 1H-MR spectroscopy study2017
- Author(s)
  Shimizu M, Suzuki Y, Yamada K, Ueki S, Watanabe M, Igarashi H, Nakada T
- Journal Title
  
  Pediatr Res
  
  Volume: 27 Issue: 1 Pages: 29-32
- DOI
  10.1111/jon.12380
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15574, KAKENHI-PROJECT-16K15643
[Journal Article] Maturational decrease of glutamate in the human cerebral cortex from childhood to young adulthood: a 1H-MR spectroscopy study.2017
- Author(s)
  Shimizu M, Suzuki Y, Yamada K, Ueki S, Watanabe M, Igarashi H, Nakada T.
- Journal Title
  
  Pediatr Res
  
  Volume: 82 Issue: 5 Pages: 749-752
- DOI
  10.1038/pr.2017.101
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10049, KAKENHI-PROJECT-16K15574, KAKENHI-PROJECT-16K15643, KAKENHI-PROJECT-17H02191
[Journal Article] Magnetic Resonance Imaging of Neurotransmitter-Related Molecules2017
- Author(s)
  Igarashi Hironaka、Ueki Satoshi、Ohno Ken、Ohkubo Masaki、Suzuki Yuji
- Journal Title
  
  Journal of Nippon Medical School
  
  Volume: 84 Issue: 4 Pages: 160-164
- DOI
  10.1272/jnms.84.160
- NAID
  130006140098
- ISSN
  1345-4676, 1347-3409
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15574, KAKENHI-PROJECT-16K15643, KAKENHI-PROJECT-17H02191
[Journal Article] Reduced CSF water influx in Alzheimer's disease supporting the b-amyloid clearance hypothesis.2015
- Author(s)
  Suzuki Y, Nakamura Y, Yamada K, Igarashi H, Kasuga K, Yokoyama Y, Ikeuchi T, Nishizawa M, Kwee IL, Nakada T
- Journal Title
  
  PLoS ONE
  
  Volume: 10 Issue: 5 Pages: e0123708-e0123708
- DOI
  10.1371/journal.pone.0123708
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15335, KAKENHI-PROJECT-25461310
[Journal Article] Multiple therapeutic effects of progranulin on experimental acute ischemic stroke.2015
- Author(s)
  Kanazawa K, Kawamura K, Takahashi T, Miura M, Tanaka Y, Koyama M, Toriyabe M, Igarashi H, Nakada T, Nishihara M, Nishizawa M, Shimohata T
- Journal Title
  
  Brain
  
  Volume: 79 Issue: 7 Pages: 1-17
- DOI
  10.1093/brain/awv079
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J03307, KAKENHI-PROJECT-25860702, KAKENHI-PROJECT-26430066, KAKENHI-PROJECT-23228004, KAKENHI-PROJECT-25461310
[Journal Article] N-acetylaspartate Decrease in Acute Stage of Ischemic Stroke:A Perspective from Experimental and Clinical Studies2015
- Author(s)
  Igarashi H, Suzuki Y, Huber VJ, Ida M, Nakada T.
- Journal Title
  
  MRMS
  
  Volume: 14 Issue: 1 Pages: 13-24
- DOI
  10.2463/mrms.2014-0039
- NAID
  130004935515
- ISSN
  1347-3182, 1880-2206
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461310
[Journal Article] Diffuse brain abnormalities in myotonic dystrophy type 1 detected by 3.0 T proton magnetic resonance spectroscopy2015
- Author(s)
  Takado Y, Terajima K, Ohkubo M, Okamoto K, Shimohata T, Nishizawa M, Igarashi H, Nakada T
- Journal Title
  
  Eur Neurol
  
  Volume: 73 Issue: 3-4 Pages: 247-256
- DOI
  10.1159/000371575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461310, KAKENHI-PROJECT-25462817
[Journal Article] Accumulation of 2-hydroxyglutarate in gliomas correlates with survival: a study by 3.0-tesla magnetic resonance spectroscopy.2014
- Author(s)
  Natsumeda M, Igarashi H, Nomura T, Ogura R, Tsukamoto Y, Kobayashi T, Aoki H, Okamoto K, Kakita A, Takahashi H, Nakada T, Fujii Y.
- Journal Title
  
  Acta Neuropathol Commun.
  
  Volume: 2 Pages: 158-158
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461310
[Journal Article] Water influx into cerebrospinal fluid is significantly reduced in senile plaque bearing transgenic mice, supporting beta-amyloid clearance hypothesis of Alzheimer's disease.2014
- Author(s)
  Igarashi H, Suzuki Y, Kwee IL, Nakada T.
- Journal Title
  
  Neurol Res.
  
  Volume: 36 Issue: 12 Pages: 1094-1098
- DOI
  10.1179/1743132814y.0000000434
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461310
[Journal Article] Water influx into cerebrospinal fluid is primarily controlled by aquaporin-4, not by aquaporin-1 : 17O JJVCPE MRI study in knockout mice2014
- Author(s)
  Igarashi H, Tsujita M, Kwee IL, Nakada T
- Journal Title
  
  Neuroreport
  
  Volume: 25巻 Issue: 1 Pages: 39-43
- DOI
  10.1097/wnr.0000000000000042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220007, KAKENHI-PROJECT-25461310
[Journal Article] Ligand-based molecular MRI;0-17 JJVCPE amyloid imaging in transgenic mice2014
- Author(s)
  Suzuki K, Igarashi H, Huber VJ, Kitaura H, Kwee IL, Nakada T
- Journal Title
  
  J Neuroimaging
  
  Volume: (受理済, 電子出版済) Issue: 6 Pages: 595-598
- DOI
  10.1111/jon.12091
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21220007, KAKENHI-PROJECT-25461310, KAKENHI-PROJECT-25870252
[Journal Article] Effects of angiopoietin-1 on hemorrhagic transformation and cerebral edema after tissue plasminogen activator treatment for ischemic stroke in rats.2014
- Author(s)
  Kawamura K, Takahashi T, Kanazawa M, Igarashi H, Nakada T, Nishizawa M, Shimohata T
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 6 Pages: e98639-e98639
- DOI
  10.1371/journal.pone.0098639
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25430063, KAKENHI-PROJECT-25461310
[Journal Article] Inhibition of aquaporin-4 significantly increases regional cerebral blood flow2013
- Author(s)
  Igarashi H, Tsujita M, Suzuki Y, Kwee IL, Nakada T
- Journal Title
  
  Neuroreport
  
  Volume: 24巻 Issue: 6 Pages: 324-328
- DOI
  10.1097/wnr.0b013e32835fc827
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220007, KAKENHI-PROJECT-25461310
[Journal Article] In vivo monitoring of arterially transplanted bone marrow mononuclear cells in a rat transient focal brain ischemia model using magnetic resonance imaging2013
- Author(s)
  Kamiya N, Ueda M, Igarashi H, Nishiyama Y, Suda S, Okubo S, Inaba T, Katayama Y
- Journal Title
  
  Neurol Res
  
  Volume: 35 Issue: 6 Pages: 573-579
- DOI
  10.1179/1743132813y.0000000171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220007, KAKENHI-PROJECT-25461310
[Journal Article] Spontaneous middle cerebral artery dissection demonstrated by high-resolution T1-weighted 3D image2013
- Author(s)
  Uemura M, Akaiwa Y, Toriyabe M, Mashima T, Terajima K, Shimohata T, Igarashi H, Nakada T, Nishizawa M
- Journal Title
  
  Cerebrovasc Dis
  
  Volume: 36 Issue: 3 Pages: 243-244
- DOI
  10.1159/000353873
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220007, KAKENHI-PROJECT-25461310
[Journal Article] In vivo monitoring of arterially transplanted bone marrow mononuclear cells in a rat transient focal brain ischemia model using magnetic resonance imaging.2013
- Author(s)
  Kamiya N, Ueda M, Igarashi H, Nishiyama Y, Suda S, Okubo S, Inaba T, Katayama Y.
- Journal Title
  
  Neurol Res.
  
  Volume: Epub Ahead of print
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220007
[Journal Article] Inhibition of VEGF signaling pathway attenuates hemorrhage after tPA treatment2011
- Author(s)
  Kanazawa M, Igarashi H, Kawamura K, Teikahashi T, Kakita A, Takahashi H, Nakada T, Nishizawa M, Shimohata T
- Journal Title
  
  J Cereb Blood Flow Metab
  
  Volume: 31 Pages: 1461-1474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220007
[Journal Article] Biochemical and histopathological alterations in TAR DNA-binding protein-43 after acute ischemic stroke in rats2011
- Author(s)
  Kanazawa M, Kakita A, Igarashi H, Takahashi T, Kawamura K, Takahashi H, Nakada T, Nishizawa M, Shimohata T
- Journal Title
  
  J Neurochem.
  
  Volume: Vol.116, No.6 Pages: 957-965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591073
[Journal Article] Expansion of Corticomedullary Junction High-Susceptibility Region (CMJ-HSR) with Aging : A Clue in the Pathogenesis of Alzheimer's Disease?2011
- Author(s)
  Nakada T, Matsuzawa H, Igarashi H, Kwee IL
- Journal Title
  
  J Neuroimaging
  
  Volume: 22 Issue: 4 Pages: 379-383
- DOI
  10.1111/j.1552-6569.2011.00607.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220007
[Journal Article] Inhibition of VEGF signaling pathway attenuates hemorrhage after tPA treatment2011
- Author(s)
  Kanazawa M, Igarashi H, Kawamura K, Takahashi T, Kakita A, Takahashi H, Nakada T, Nishizawa M, Shimohata T
- Journal Title
  
  J Cereb Blood Flow Metab
  
  Volume: Vol.31, No.6 Pages: 1461-1674
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591073
[Journal Article] Separation of perfusion signals from diffusion-weighted image series enabled by independent component analysis2011
- Author(s)
  Suzuki K, Igarashi H, Watanabe M, Nakamura Y, Nakada T
- Journal Title
  
  J Neuroimaging
  
  Volume: 21 Pages: 384-394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220007
[Journal Article] Brainstem metabolites in multiple system atrophy of cerebellar type : 3.0-T magnetic resonance spectroscopy study2011
- Author(s)
  Takado Y, Igarashi H, Terajima K, Shimohata T, Ozawa T, Okamoto K, Nishizawa M, Nakada T
- Journal Title
  
  Mov Disord
  
  Volume: 26 Pages: 1297-1302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220007
[Journal Article] Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema.2010
- Author(s)
  Igarashi H, Huber VJ, TsujitaM, Nakada T.
- Journal Title
  
  Neurol Sci
  
  Volume: 32 Pages: 113-116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220007
[Journal Article] Separation of Perfusion Signals from Diffusion-Weighted Image Series Enabled by Independent Component Analysis2010
- Author(s)
  Suzuki K, Igarashi H, Watanabe M, Nakamura Y, Nakada T.
- Journal Title
  
  J Neuroimaging
  
  Volume: (Epub ahead of print.)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21220007
[Presentation] 星細胞腫及び乏突起膠腫の鑑別、悪性度診断における7T MRI-SWIの有用性2023
- Author(s)
  棗田学、松澤等、塚本佳広、小倉良介、岡本浩一郎、五十嵐博中、藤井幸彦
- Organizer
  第45回日本脳神経CI学会
- Data Source
  KAKENHI-PROJECT-21H03042
[Presentation] 星細胞腫及び乏突起膠腫の鑑別、悪性度診断における7T MRI SWIの有用性2022
- Author(s)
  棗田学、松澤等、塚本佳広、小倉良介、岡本浩一郎、柿田明美、五十嵐博中、中田力、藤井幸彦
- Organizer
  第81回日本脳神経外科学会学術総会
- Data Source
  KAKENHI-PROJECT-21H03042
[Presentation] Proton Magnetic Resonance Spectroscopy ―過去・現在・未来―2022
- Author(s)
  五十嵐　博中
- Organizer
  日本ヒト脳機能マッピング学会
- Invited
- Data Source
  KAKENHI-PROJECT-18H02762
[Presentation] glyCESTイメージングの開発と応用2021
- Author(s)
  大野健、大久保正樹、渡辺将樹、五十嵐博中
- Organizer
  脳循環代謝学会
- Data Source
  KAKENHI-PROJECT-18H02762
[Presentation] 19F-Magnetic Resonance Spectroscopic Imaging visualizes the distribution of Matrix metalloproteinases in ischemic brain using in vivo2019
- Author(s)
  Igarashi H
- Organizer
  BRAIN & BRAIN PET 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02762
[Presentation] MMP特異的19Fトレーサーの開発と虚血性脳血管障害モデルへの応用2019
- Author(s)
  五十嵐　博中
- Organizer
  脳卒中学会
- Data Source
  KAKENHI-PROJECT-16K15574
[Presentation] Alzheimer patients show significant disturbance in water influx into CSF space2014
- Author(s)
  Nakada T, Igarashi H, Suzuki Y, Kwee IL
- Organizer
  66回アメリカ神経学会
- Place of Presentation
  米国・フィラデルフィア
- Year and Date
  2014-05-01
- Data Source
  KAKENHI-PROJECT-21220007
[Presentation] Dynamics of water in brain : focuse on ischemic edema2012
- Author(s)
  Igarashi H
- Organizer
  第42回生理研国際シンポジウム生理研・新潟脳研合同シンポジウム
- Place of Presentation
  岡崎(招待講演)
- Year and Date
  2012-03-07
- Data Source
  KAKENHI-PROJECT-21220007
[Presentation] VEGFシグナル阻害はtPAによる血栓溶解療法後の脳出血を抑制する2011
- Author(s)
  下畑享良,金澤雅人,五十嵐博中,高橋哲哉,川村邦雄,柿田明美,高橋均,中田力,西澤正豊
- Organizer
  日本神経学会学術集会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-21591073
[Presentation] Brainstem Myoinositol as a Biomarker of Disease Severity in MSA-C : A3TIH-MRS Study2010
- Author(s)
  Takado Y, Igarashi H, Nakada T, et al.
- Organizer
  American Academy of Neurology 62nd AnnualMeeting
- Place of Presentation
  カナダ、トロント
- Year and Date
  2010-04-15
- Data Source
  KAKENHI-PROJECT-21220007
[Presentation] TDP43 may contribute to the protective effects of hypothermia against rat focal cerebral ischemia2009
- Author(s)
  Kanazawa M, Kakita A, Igarashi H, Takahashi T, Takahashi H, Nishizawa M, Nakada T, Shimohata T
- Organizer
  International stroke conference 2009
- Place of Presentation
  サン・ディエゴ
- Year and Date
  2009-02-19
- Data Source
  KAKENHI-PROJECT-19590982
[Presentation] ラット中大脳動脈塞栓モデルにおける血管内皮細胞のVEGF発現2008
- Author(s)
  金澤雅人, 五十嵐博中, 柿田明美, 高橋均, 西澤正豊, 下畑享良
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19590982
[Presentation] TDP43 may contribute to the protective effects of hypothermia against rat focal cerebral ischemia2008
- Author(s)
  Kanazawa M, Kakita A, Igarashi H, Takahashi T, Nishizawa M, Nakada T, and Shimohata T
- Organizer
  International Stroke conference 2008
- Place of Presentation
  SanDiego
- Year and Date
  2008-02-19
- Data Source
  KAKENHI-PROJECT-19590982
[Presentation] ラット中大脳動脈塞栓モデルにおける血管内皮細胞のVEGF発現2008
- Author(s)
  金澤雅人, 五十嵐博中, 柿田明美, 高橋均, 西澤正豊, 下畑享良
- Organizer
  日本神経学会総会
- Year and Date
  2008-05-20
- Data Source
  KAKENHI-PROJECT-19590982
[Presentation] 高磁場MRS；マウスからヒトへ
- Author(s)
  五十嵐博中
- Organizer
  第41回日本磁気共鳴医学会大会
- Place of Presentation
  徳島
- Invited
- Data Source
  KAKENHI-PROJECT-25461310
[Presentation] Alzheimer Patients Show Significant Disturbance in Water Influx into CSF Space Strongly Supporting β-amyloid Clearance Hypothesis
- Author(s)
  Nakada T, Igarashi H, Suzuki Y, Kwee IL
- Organizer
  66th Annual Meeting of the American Academy of Neurology
- Place of Presentation
  米国、フィラデルフィア
- Data Source
  KAKENHI-PROJECT-21220007
[Presentation] 高磁場MRSの展望
- Author(s)
  五十嵐　博中
- Organizer
  第26回日本王循環代謝学会
- Place of Presentation
  岡山
- Year and Date
  2014-11-21 – 2014-11-22
- Invited
- Data Source
  KAKENHI-PROJECT-25461310
[Presentation] 超高磁場MRIの現状と日本の将来
- Author(s)
  五十嵐博中
- Organizer
  第15回日本ヒト脳機能マッピング学会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25461310

1. KAKITA Akiyoshi (80281012)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
2. HUBER Vincent (40422620)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. SHIMOHATA Takayoshi (60361911)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
4. NAKADA Tsutomu (50281720)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
5. FUJII Yukihiko (40283014)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
6. TSUJITA Mika (60397180)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. SUZUKI Kiyotaka (40303169)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
8. Kawachi Izumi (40432083)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. Horii Arata (30294060)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 和田森直 (60303179)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. NISHIZAWA Masatoyo (80198457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
12. TAKAHASHI Tetsuya (20515663)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
13. Nishiyama Yasuhiro (20350077)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ONODERA OSMAU (20303167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 若林あや子 (30328851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 大久保真樹 (10203738)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. 上村昌寛 (00836710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 今野卓哉 (20837372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 加藤泰介 (30598496)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 清水宏 (40608767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 金澤雅人 (80645101)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
22. 棗田学 (00515728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
23. 田井中一貴 (80506113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 園部元康 (50455169)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 佐治越爾 (00706418)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
26. KWEE L Ingrid

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
27. ZHANG Bingwen

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. 池内健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 春日健作

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 伊藤浩介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 福地健郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 鈴木雄治

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
33. 山田謙一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
34. 大野健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 松本雅記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Igarashi Hironaka 五十嵐 博中

IGARASHI Hironaka 五十嵐 博中

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筋委縮性側索硬化症における多層的MRIバイオマーカーによる早期診断と病態進行可視化Principal Investigator

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Development of a Novel Treatment for Normal Pressure Hydrocephalus with an Aquaporin-4 ModulatorPrincipal Investigator

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Development of a method to assess cognitive reserve in Alzheimer's disease using chemical exchange saturation transfer MRI.Principal Investigator

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Development of in vivo drug monitoring precedure using CESt MRIPrincipal Investigator

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Development of MMP specific 19F-MRS tracer to assess the disruption of neuro vascular unit in brainPrincipal Investigator

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Igarashi Hironaka 五十嵐博中

IGARASHI Hironaka 五十嵐博中