Gemma Akihiko 弦間昭彦

… Alternative Names

GENMA Akihiko 弦間昭彦

GEMMA Akihiko 弦間昭彦

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Researcher Number	20234651
Other IDs
Affiliation (Current)	2025: 日本医科大学, 大学院医学研究科, 大学院教授
Affiliation (based on the past Project Information) *help	2018 – 2019: 日本医科大学, 大学院医学研究科, 大学院教授 2017: 日本医科大学, 医学部, 教授 2016: 日本医科大学, 大学院医学研究科, 大学院教授 2012 – 2015: 日本医科大学, 医学(系)研究科(研究院), 教授 2014: 日本医科大学, 大学院医学研究科, 教授 … More 2008 – 2011: Nippon Medical School, 大学院・医学研究科, 教授 2007: Nippon Medical School, Department of Internal Medicine, Associate Prof 2006: 日本医科大学, 医学部, 助教授 2004: NIPPON MEDICAL SCHOOL, 4^<TH> DEPT OF INTERNAL MED, ASSOCIATE PROF., 医学部, 助教授 1998 – 2003: 日本医科大学, 医学部, 講師 1995: 日本医科大学, 医学部, 講師 1994 – 1995: 日本医科大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine Except Principal Investigator Respiratory organ internal medicine / Respiratory organ internal medicine / Pathological medical chemistry
Keywords	Principal Investigator 肺癌 / cDNA array / 転移 / SiRNA / Galectin-1 / Gene Expression / Macroarray / Microarray / Metastasis / Lung Cancer … More / マクロアレイ / 遺伝子発現 / VEGFR / EGFR / 2D-DIGE / 抗体アレイ / イメージング / プロテオーム / PROTEOME / METASTASIS / LUNG CANCER / CGH array / EST クローン / expression profile / 発現プロファイル / CDNA array / Macro array / Micro array / マイクロアレイ / p53 / driver gene 変異 / 転写因子 / アポトーシス / cancer stem cell / セカンドアタック / ドライバー遺伝子 / シグナル情報 / 網羅的解析 / 感受性予測 / 分子標的治療 / 肺癌薬剤感受性プロテオーム / "D-DIGE / バイオイメージング / 分子標的薬 / 薬物療法 / 薬剤感受性 … More Except Principal Investigator 肺癌 / EMT / TGF-β / cDNA array / Smad4 / hMAD2 / MMAC1 / allelic loss / PTH2 / PTEN / マイクロRNA / Sox2 / がん化学療法 / がんの再発 / グルコース代謝 / O-GlcNAc修飾 / STAT3 / がんの再発防止 / がん微小環境 / 肺がん / OCT4 / SOX2 / リプログラミング / p53 / 薬剤スクリーニング / PRMT5 / MEP50 / GLI1 / O-GlcNAcylation / IL-8 / がん治療 / がん幹細胞 / IPF / Lung cancer / Chronic epithelium damage / 2D-DIGE / 抗体アレイ / cDNA / 発癌分子機構 / 特発性肺線維症 / 慢性上皮傷害 / Transcriptional disorder / Carcinogenesis / Idiopathic pulmonary fibrosis / 遺伝子発現異常 / 遺伝子異常 / 発がん / 転写異常 / CDNA array / 発癌 / 肺線維症 / Genomic structure / Insulin-like growth factor 2 receptor / Insulin-like qrowth factor 2 Receptor / insulin-like growth factor 2 Receptor / hHAD2 / MHAC1 / ゲノム構造 / Insulin-like growth factor 2 Receptor / Integrin / Invasion / Adhesion / Nude mouse / Highly metastatic cell line / Metastases / Cell Line / Lung Cancer / ヒト肺癌細胞株 / インテグリン / 浸潤 / 接着 / ヌードマウス / 高転移株 / 転移 / 培養細胞 / 肺カルチノイド / 融合遺伝子 / 遺伝子変異 / 肺神経内分泌腫瘍 / 次世代シーケンサー / トランスレーショナルリサーチ / 血清 / エクソソーム / 薬剤感受性 Less

Generation and maintenance mechanism of cancer stem cells in tumor microenvironment, involved in lung cancer development and reocurrence.
- Principal Investigator
  
  Tanaka Nobuyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nippon Medical School
Identification of the genomic landscape in pulmonary neuroendocrine tumor
- Principal Investigator
  
  MIYANAGA AKIHIKO
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
Finishing blow therapy in lung cancer with driver gene mutationPrincipal Investigator
- Principal Investigator
  
  Gemma Akihiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
Identification of serum exosomal microRNA in lung cancer
- Principal Investigator
  
  SEIKE MASAHIRO
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
Development of molecular predictive model for molecular targeted therapy in lung cancer using pathway analysisPrincipal Investigator
- Principal Investigator
  
  GEMMA Akihiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
Prediction of drug sensitivity and development of a therapeutic strategy by microRNAs in lung cancer
- Principal Investigator
  
  SEIKE Masahiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
Identification of chemosensitivity predictive factors in lung cancer cells and chemosensitivity prediction by imagePrincipal Investigator
- Principal Investigator
  
  GENMA Akihiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
Carcinogenesis in chronic epithelial damage of the lung
- Principal Investigator
  
  KUDOH Shoji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
The mechanisms of highly metastetic capasity in highly metastatic subpopulations of lung adenocarcinoma cell line and these clinical applicationsPrincipal Investigator
- Principal Investigator
  
  GEMMA Akihiko
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
The mechanisms of pulmonary carciniogenesis in idiopathic pulmonary fibrosis
- Principal Investigator
  
  KUDOH Shoji
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
The mechanisms of the highly metastatic property using human lung cancer sublines with highly metastatic potential established and the expolation of the molecular targets for lung cancer therapyPrincipal Investigator
- Principal Investigator
  
  GEMMA Akihiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
Study of mechanisms of the highly metastatic feature using human lung cancer sublines with highly metastatic property establishedPrincipal Investigator
- Principal Investigator
  
  GEMMA Akihiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School
Determination of full-length cDNA and genomic structure of the tumor suppressor gene candidates in lung cancer and screening for their mutations
- Principal Investigator
  
  KUDOH Shoji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  NIPPON MEDICAL SCHOOL
Establishment of a highly metastatic human lung cancer cell line and investigaion of mechanism associating with the highly metastatic ability
- Principal Investigator
  
  KUDOH Shoji
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Nippon Medical School

All 2018 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2004

All Journal Article Presentation Book

[Book] オンコロジークリニカルガイド「肺癌化学療法」2014
- Author(s)
  弦間昭彦
- Total Pages
  432
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-25461172
[Book] 分子標的治療薬マスターガイド2014
- Author(s)
  弦間昭彦
- Total Pages
  255
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-25461172
[Book] 呼吸器疾患診療　最新ガイドライン2014
- Author(s)
  弦間昭彦
- Total Pages
  395
- Publisher
  総合医学社
- Data Source
  KAKENHI-PROJECT-25461172
[Book] 肺癌診療Q＆A2013
- Author(s)
  弦間昭彦
- Total Pages
  421
- Publisher
  中外出版社
- Data Source
  KAKENHI-PROJECT-25461172
[Book] 肺癌診療Q&A2011
- Author(s)
  弦間昭彦, 他
- Total Pages
  343
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-21591006
[Book] 分子標的治療薬の副作用マネージメント2011
- Author(s)
  弦間昭彦, 他
- Total Pages
  225
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-21591006
[Book] 抗癌剤の効果予測因子としてのバイオマーカー2010
- Author(s)
  清家正博、弦間昭彦
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-21591008
[Book] 抗がん剤d. 間質性肺炎医薬品副作用ハンドブック(高橋隆一編集)2008
- Author(s)
  弦間昭彦
- Publisher
  日本臨床社(東京)
- Data Source
  KAKENHI-PROJECT-19590919
[Book] 分子呼吸器病2007
- Author(s)
  清家正博、弦間昭彦
- Total Pages
  4
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590869
[Book] 2.薬効群別副作用14)抗がん剤d.間質性肺炎医薬品副作用学-薬品の安全使用 Update-(高橋隆一編集)2007
- Author(s)
  弦間昭彦
- Publisher
  日本臨床社(東京)
- Data Source
  KAKENHI-PROJECT-19590919
[Book] 医学の歩み呼吸器疾患-state of arts2007
- Author(s)
  岡野哲也, 弦間昭彦
- Total Pages
  5
- Publisher
  医歯薬出版株式会社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590869
[Book] 第12章癌緊急対応と支持療法4抗癌剤による間質性肺炎(ゲフィチニブ、ボルテゾミブを含む)「Cancer Treatment Navigator」(中川和彦編集)2007
- Author(s)
  弦間昭彦
- Publisher
  メディカルビュー社(東京)
- Data Source
  KAKENHI-PROJECT-19590919
[Book] 総合臨床2007
- Author(s)
  弦間昭彦
- Total Pages
  2
- Publisher
  文光堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590869
[Book] IX.分子標的治療CE.薬剤性肺障害。肺癌のすべて(江口研二、横井香平、弦間昭彦編集)2007
- Author(s)
  弦間昭彦
- Publisher
  文光堂(東京)
- Data Source
  KAKENHI-PROJECT-19590919
[Book] 腫瘍性疾患3非小細胞肺癌の集学的治療呼吸器疾患最新の治療2007-2009(工藤翔二、中田紘一郎、貫和敏博編集)2007
- Author(s)
  峯岸裕司、弦間昭彦
- Publisher
  南江堂(東京)
- Data Source
  KAKENHI-PROJECT-19590919
[Book] Annual Review 呼吸器 20072007
- Author(s)
  弦間昭彦
- Total Pages
  5
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-18590869
[Book] 第1部5章総論1薬物療法E抗癌薬。「呼吸器専門医テキスト」(工藤翔二、中田紘一郎、永井厚志、大田健編集)2007
- Author(s)
  篠田欣也、弦間昭彦
- Publisher
  南江堂(東京)
- Data Source
  KAKENHI-PROJECT-19590919
[Book] 肺癌のすべて2007
- Author(s)
  弦間昭彦
- Total Pages
  9
- Publisher
  文光堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590869
[Book] II.肺癌の分子生物学3.癌の生物学と臨床応用の現状。肺癌のすべて(江口研二、横井香平、弦間昭彦編集)2007
- Author(s)
  弦間昭彦
- Publisher
  文光堂(東京)
- Data Source
  KAKENHI-PROJECT-19590919
[Book] 医薬品副作用学-薬品の安全使用Update2007
- Author(s)
  弦間昭彦
- Total Pages
  5
- Publisher
  日本臨床社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590869
[Book] 「発見診断」肺癌を合併しやすい呼吸器疾患。MOOK「肺癌の臨床2006-2007」(監修加藤治文、西條長宏、福岡正博、小林紘一、海老原善郎、井内康輝、早川和重)2007
- Author(s)
  弦間昭彦
- Publisher
  篠原出版新社(東京)
- Data Source
  KAKENHI-PROJECT-19590919
[Book] 第2章診断法ー現況と最新の進歩肺癌診療におけるDNA診断。医学の歩み呼吸器疾患-state of arts-Ver.5.(北村諭、工藤翔二、石井芳樹編集)2007
- Author(s)
  岡野哲也, 弦間昭彦
- Publisher
  医歯薬出版株式会社(東京)
- Data Source
  KAKENHI-PROJECT-19590919
[Book] Annual Review呼吸器20072007
- Author(s)
  弦間昭彦
- Total Pages
  5
- Publisher
  中外医学社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590869
[Book] MOOK「肺癌の臨床2006-2007」2007
- Author(s)
  弦間昭彦
- Total Pages
  5
- Publisher
  篠原出版新社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590869
[Book] II疾患の病因と病態8肺の線維化と発癌 Annual Review 呼吸器 2007(工藤翔二、土屋了介、金沢実、大田健編集)2007
- Author(s)
  弦間昭彦
- Publisher
  中外医学社(東京)
- Data Source
  KAKENHI-PROJECT-19590919
[Journal Article] Identification of haptoglobin peptide as a novel serum biomarker for lung squamous cell carcinoma by serum proteome and peptidome profiling.2016
- Author(s)
  Okano T, Seike M, Kuribayashi H, Soeno C, Ishii T, Kida K, Gemma A.
- Journal Title
  
  Int J Oncol.
  
  Volume: 48(3) Issue: 3 Pages: 945-52
- DOI
  10.3892/ijo.2016.3330
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461172
[Journal Article] Unique intravascular tumor microenvironment predicting recurrence of lung squamous cell carcinoma.2016
- Author(s)
  Hisakane K, Saruwatari K, Fujii S, Kirita K, Umemura S, Matsumoto S, Yoh K, Niho S, Ohmatsu H, Kuwata T, Ochiai A, Gemma A, Tsuboi M, Goto K, Ishii G.
- Journal Title
  
  J Cancer Res Clin Oncol.
  
  Volume: 142(3) Issue: 3 Pages: 593-600
- DOI
  10.1007/s00432-015-2068-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461172
[Journal Article] Cisplatin-induced apoptosis in non-small-cell lung cancer cells is dependent on Bax- and Bak-induction pathway and synergistically activated by BH3-mimetic ABT-263 in p53 wild-type and mutant cells.2016
- Author(s)
  Matsumoto M, Nakajima W, Seike M, Gemma A, Tanaka N.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 473(2) Issue: 2 Pages: 490-6
- DOI
  10.1016/j.bbrc.2016.03.053
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-26670164, KAKENHI-PROJECT-16K11161
[Journal Article] miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells.2016
- Author(s)
  Nishijima N, Seike M, Soeno C, Chiba M, Miyanaga A, Noro R, Sugano T, Matsumoto M, Kubota K, Gemma A.
- Journal Title
  
  Int J Oncol.
  
  Volume: 48(3) Issue: 3 Pages: 937-44
- DOI
  10.3892/ijo.2016.3331
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-16K09561
[Journal Article] Identification of adverse events that have a negative impact on quality of life in a clinical trial comparing docetaxel versus S-1 with cisplatin in lung cancer.2016
- Author(s)
  Aotani E, Hamano T, Gemma A, Takeuchi M, Takebayashi T, Kobayashi K.
- Journal Title
  
  Int J Clin Oncol.
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461172
[Journal Article] Prognostic significance of PIK3CA and SOX2 in Asian patients with lung squamous cell carcinoma.2015
- Author(s)
  Iijima Y, Seike M, Noro R, Ibi T, Takeuchi S, Mikami I, Koizumi K, Usuda J, Gemma A.
- Journal Title
  
  Int J Oncol.
  
  Volume: 46(2) Issue: 2 Pages: 505-12
- DOI
  10.3892/ijo.2014.2742
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461172
[Journal Article] MiR-379/411 cluster regulates IL-18 and contributes to drug resistance in malignant pleural mesothelioma.2015
- Author(s)
  Yamamoto K, Seike M, Takeuchi S, Soeno C, Miyanaga A, Noro R, Minegishi Y, Kubota K, Gemma A.
- Journal Title
  
  Oncol Rep.
  
  Volume: 32(6) Issue: 6 Pages: 2365-72
- DOI
  10.3892/or.2014.3481
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461172
[Journal Article] Podoplanin-expressing cancer-associated fibroblasts inhibit small cell lung cancer growth.2015
- Author(s)
  Takahashi A, Ishii G, Neri S, Yoshida T, Hashimoto H, Suzuki S, Umemura S, Matsumoto S, Yoh K, Niho S, Goto K, Ohmatsu H, Nagai K, Gemma A, Ohe Y, Ochiai A.
- Journal Title
  
  Oncotarget.
  
  Volume: 6(11) Pages: 9531-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461172
[Journal Article] Inhibition of ABCB1 Overcomes Cancer Stem Cell-like Properties and Acquired Resistance to MET Inhibitors in Non-Small Cell Lung Cancer.2015
- Author(s)
  Sugano T, Seike M, Noro R, Soeno C, Chiba M, Zou F, Nakamichi S, Nishijima N, Matsumoto M, Miyanaga A, Kubota K, Gemma A.
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: 14(11) Issue: 11 Pages: 2433-40
- DOI
  10.1158/1535-7163.mct-15-0050
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461172
[Journal Article] Nintedanib modulates surfactant protein-D expression in A549 human lung epithelial cells via the c-Jun N-terminal kinase-activator protein-1 pathway.2015
- Author(s)
  Kamio K, Usuki J, Azuma A, Matsuda K, Ishii T, Inomata M, Hayashi H, Kokuho N, Fujita K, Saito Y, Miya T, Gemma A.
- Journal Title
  
  Pulm Pharmacol Ther.
  
  Volume: 5539(15) Pages: 00036-00036
- DOI
  10.1016/j.pupt.2015.03.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-15K19433
[Journal Article] MET FISH-positive status predicts short progression-free survival and overall survival after gefitinib treatment in lung adenocarcinoma with EGFR mutation.2015
- Author(s)
  Noro R, Seike M, Zou F, Soeno C, Matsuda K, Sugano T, Nishijima N, Matsumoto M, Kitamura K, Kosaihira S, Minegishi Y, Yoshimura A, Kubota K, Gemma A.
- Journal Title
  
  BMC Cancer
  
  Volume: 15(1) Pages: 31-31
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461172
[Journal Article] Factors associated with a poor response to gefitinib in the NEJ002 study: Smoking and the L858R mutation.2015
- Author(s)
  Fukuhara T, Yoshizawa H et al.
- Journal Title
  
  Lung Cancer
  
  Volume: 88 Issue: 2 Pages: 181-6
- DOI
  10.1016/j.lungcan.2015.02.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591156, KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-26461175, KAKENHI-PROJECT-15K09164, KAKENHI-PROJECT-15K09237, KAKENHI-PROJECT-15K15320
[Journal Article] Efficacy of chemotherapy after first-line gefitinib therapy in EGFR mutation-positive advanced non-small cell lung cancer-data from a randomized Phase III study comparing gefitinib with carboplatin plus paclitaxel (NEJ002)2015
- Author(s)
  Miyauchi E, Inoue A, Kobayashi K, Maemondo M, Sugawara S, Oizumi S, Isobe H, Gemma A, Saijo Y, Yoshizawa H, Hagiwara K, Nukiwa T; North-East Japan Study Group
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 45 Issue: 7 Pages: 670-6
- DOI
  10.1093/jjco/hyv054
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09164, KAKENHI-PROJECT-15K15320, KAKENHI-PROJECT-25461172
[Journal Article] Phase II study of carboplatin, docetaxel and bevacizumab for chemotherapy-naive patients with advanced non-squamous non-small cell lung cancer.2015
- Author(s)
  Takiguchi, Y., Iwasawa, S., Minato, K., Miura, Y., Gemma, A., Noro, R., Yoshimori, K., Shingyoji, M., Hino, M., Ando, M. and Okamoto, H.
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 20 Issue: 4 Pages: 659-667
- DOI
  10.1007/s10147-014-0755-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461182, KAKENHI-PROJECT-25461172
[Journal Article] A randomized phase III trial of oral S-1 plus cisplatin versus docetaxel plus cisplatin in Japanese patients with advanced non-small-cell lung cancer: TCOG0701 CATS trial.2015
- Author(s)
  Kubota, K., Sakai, H., Katakami, N., Nishio, M., Inoue, A., Okamoto, H., Isobe, H., Kunitoh, H., Takiguchi, Y., Kobayashi, K., Nakamura, Y., Ohmatsu, H., Sugawara, S., Minato, K., Fukuda, M., Yokoyama, A., Takeuchi, M., Michimae, H., Gemma, A. and Kudoh, S.
- Journal Title
  
  Annals of Oncology
  
  Volume: 26 Issue: 7 Pages: 1401-1408
- DOI
  10.1093/annonc/mdv190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26461182, KAKENHI-PROJECT-25461172
[Journal Article] Randomized phase II study of concurrent versus sequential alternating gefitinib and chemotherapy in previously untreated non-small cell lung cancer with sensitive EGFR mutations: NEJ005/TCOG0902.2015
- Author(s)
  Sugawara S, Oizumi S, Minato K, Harada T, Inoue A, Fujita Y, Maemondo M, Yoshizawa H, Ito K, Gemma A, Nishitsuji M, Harada M, Isobe H, Kinoshita I, Morita S, Kobayashi K, Hagiwara K, Kurihara M, Nukiwa T; North East Japan Study Group and Tokyo Cooperative Oncology Group
- Journal Title
  
  Ann Oncol.
  
  Volume: 26(5) Issue: 5 Pages: 888-94
- DOI
  10.1093/annonc/mdv063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-26461175, KAKENHI-PROJECT-15K09164
[Journal Article] First-line gefitinib for elderly patients with advanced NSCLC harboring EGFR mutations. A combined analysis of North-East Japan Study Group studies.2015
- Author(s)
  Morikawa N, Minegishi Y, Inoue A, Maemondo M, Kobayashi K, Sugawara S, Harada M, Hagiwara K, Okinaga S, Oizumi S, Nukiwa T, Gemma A; North-East Japan Study Group.
- Journal Title
  
  Expert Opin Pharmacother.
  
  Volume: 16(4) Issue: 4 Pages: 465-72
- DOI
  10.1517/14656566.2015.1002396
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-15K09164
[Journal Article] Effective Crizotinib schedule for an elderly patient with ALK rearranged non-small-cell lung cancer: a case report.2015
- Author(s)
  Fukuizumi A, Miyanaga A, Seike M, Kato Y, Nakamichi S, Chubachi K, Matsumoto M, Noro R, Minegishi Y, Kunugi S, Kubota K, Gemma A
- Journal Title
  
  BMC Res Notes.
  
  Volume: 8 Issue: 1 Pages: 165-165
- DOI
  10.1186/s13104-015-1126-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461204, KAKENHI-PROJECT-25461172
[Journal Article] Control of the MYC-eIF4E axis plus mTOR inhibitor treatment in small cell lung cancer.2015
- Author(s)
  Matsumoto M, Seike M, Noro R, Soeno C, Sugano T, Takeuchi S, Miyanaga A, Kitamura K, Kubota K, Gemma A.
- Journal Title
  
  BMC Cancer
  
  Volume: 15(1) Pages: 241-241
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461172
[Journal Article] Hippo Pathway Gene Mutations in Malignant Mesothelioma, Revealed by RNA and Targeted Exon Sequencing2015
- Author(s)
  Miyanaga A, Masuda M, Tsuta K, Kawasaki K, Nakamura Y, Sakuma T, Asamura H, Gemma A, Yamada T.
- Journal Title
  
  J Thorac Oncol
  
  Volume: 10(5) Issue: 5 Pages: 844-851
- DOI
  10.1097/jto.0000000000000493
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461168, KAKENHI-PROJECT-25461172
[Journal Article] A phase II study of erlotinib monotherapy in pre-treated non-small cell lung cancer without EGFR gene mutation who have never/light smoking history: Re-evaluation of EGFR gene status (NEJ006/TCOG0903)2014
- Author(s)
  Matsumoto Y, Maemondo M, Ishii Y, Okudera K, Demura Y, Takamura K, Kobayashi K, Morikawa N, Gemma A, Ishimoto O, Usui K, Harada M, Miura S, Fujita Y, Sato I, Saijo Y;
- Journal Title
  
  Lung Cancer
  
  Volume: 86 Issue: 2 Pages: 195-200
- DOI
  10.1016/j.lungcan.2014.08.019
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591184, KAKENHI-PROJECT-25461172
[Journal Article] Clinical features, anti-cancer treatments and outcomes of lung cancer patients with combined pulmonary fibrosis and emphysema.2014
- Author(s)
  Minegishi Y, Kokuho N, Miura Y, Matsumoto M, Miyanaga A, Noro R, Saito Y, Seike M, Kubota K, Azuma A, Kida K, Gemma A.
- Journal Title
  
  Lung Cancer
  
  Volume: 85(2) Issue: 2 Pages: 258-63
- DOI
  10.1016/j.lungcan.2014.05.016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461172
[Journal Article] Nestin regulates proliferation, migration, invasion and stemness of lung adenocarcinoma2014
- Author(s)
  Narita K, Matsuda Y, Seike M, Naito Z, Gemma A, Ishiwata T
- Journal Title
  
  Int J Oncol
  
  Volume: 44(4) Issue: 4 Pages: 1118-30
- DOI
  10.3892/ijo.2014.2278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590477, KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-25462127
[Journal Article] Bortezomib therapy-related lung disease in Japanese patients with multiple myeloma: incidence, mortality and clinical characterization.2014
- Author(s)
  Yoshizawa K, Mukai HY, Miyazawa M, Miyao M, Ogawa Y, Ohyashiki K, Katoh T, Kusumoto M, Gemma A, Sakai F, Sugiyama Y, Hatake K, Fukuda Y, Kudoh S.
- Journal Title
  
  Cancer Sci.
  
  Volume: 105(2) Issue: 2 Pages: 195-201
- DOI
  10.1111/cas.12335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461172
[Journal Article] Significance of osteopontin in the sensitivity of malignant pleural mesothelioma to pemetrexed.2014
- Author(s)
  Takeuchi S, Seike M, Noro R, Soeno C, Sugano T, Zou F, Uesaka H, Nishijima N, Matsumoto M, Minegishi Y, Kubota K, Gemma A.
- Journal Title
  
  Int J Oncol.
  
  Volume: 44(6) Issue: 6 Pages: 1886-94
- DOI
  10.3892/ijo.2014.2370
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461172
[Journal Article] Final safety and efficacy of erlotinib in the phase 4 POLARSTAR surveillance study of 10 708 Japanese patients with non-small-cell lung cancer.2014
- Author(s)
  Gemma A, Kudoh S, Ando M, Ohe Y, Nakagawa K, Johkoh T, Yamazaki N, Arakawa H, Inoue Y, Ebina M, Kusumoto M, Kuwano K, Sakai F, Taniguchi H, Fukuda Y, Seki A, Ishii T, Fukuoka M.
- Journal Title
  
  Cancer Sci.
  
  Volume: 105(12) Issue: 12 Pages: 1584-90
- DOI
  10.1111/cas.12550
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461172
[Journal Article] Effectiveness of gefitinib against non-small-cell lung cancer with the uncommon EGFR mutations G719X and L861Q.2014
- Author(s)
  Watanabe S, Yoshizawa H et al.
- Journal Title
  
  J Thorac Oncol.
  
  Volume: 11 Issue: 2 Pages: 189-94
- DOI
  10.1097/jto.0000000000000048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591156, KAKENHI-PROJECT-25461172
[Journal Article] MiR-134/487b/655 cluster regulates TGF-β-induced　epithelial-mesenchymal transition and drug resistance to gefitinib by targeting MAGI2 in lung　adenocarcinoma cells2014
- Author(s)
  Kitakura K, Seike M, Okano T et.al
- Journal Title
  
  Molecular Cancer Therapeutic
  
  Volume: 13(2) Issue: 2 Pages: 444-453
- DOI
  10.1158/1535-7163.mct-13-0448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591179, KAKENHI-PROJECT-25461172
[Journal Article] Panitumumab in Japanese patients with unresectable colorectal cancer: a post-marketing surveillance study of 3085 patients.2014
- Author(s)
  Boku N, Sugihara K, Kitagawa Y, Hatake K, Gemma A, Yamazaki N, Muro K, Hamaguchi T, Yoshino T, Yana I, Ueno H, Ohtsu A.
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 44(3) Issue: 3 Pages: 214-23
- DOI
  10.1093/jjco/hyt196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461172
[Journal Article] A descriptive analysis of post-chemotherapy development of interstitial lung disease using spontaneous reporting data in Japan.2014
- Author(s)
  Hirakawa A, Yonemori K, Kuwatsuka Y, Kodaira M, Yamamoto H, Yunokawa M, Hamada A, Shimizu C, Tamura K, Gemma A, Fujiwara Y.
- Journal Title
  
  Curr Drug Saf.
  
  Volume: 9(3) Pages: 220-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461172
[Journal Article] Randomized Phase II Trial Comparing Carboplatin Plus Weekly Paclitaxel and Docetaxel Alone in Elderly Patients With Advanced Non-Small Cell Lung Cancer: North Japan Lung Cancer Group Trial 08012014
- Author(s)
  Maemondo M, Inoue A, Sugawara S, Harada T, Minegishi Y, Usui K, Miwa K, Morikawa N, Kambe M, Ube K, Watanabe K, Ishimoto O, Sakakibara T, Gemma A, Nukiwa T
- Journal Title
  
  Oncologist
  
  Volume: 19 Issue: 4 Pages: 352-353
- DOI
  10.1634/theoncologist.2013-0411
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591184, KAKENHI-PROJECT-25461145, KAKENHI-PROJECT-25461172
[Journal Article] Incidence and clinical features of drug-induced lung injury in patients with advanced colorectal cancer receiving cetuximab: results of a prospective multicenter registry.2014
- Author(s)
  Satoh T, Gemma A, Kudoh S, Sakai F, Yamaguchi K, Watanabe T, Ishiguro M, Inoshiri S, Izawa M, Sugihara K, Sakata Y.
- Journal Title
  
  Jpn J Clin Oncol.
  
  Volume: 44(11) Issue: 11 Pages: 1032-9
- DOI
  10.1093/jjco/hyu128
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-25670577
[Journal Article] Distinct outcome of stage I lung adenocarcinoma with ACTN4 cell motility gene amplification.2013
- Author(s)
  Noro R1, Honda K, Tsuta K, Ishii G, Maeshima AM, Miura N, Furuta K, Shibata T, Tsuda H, Ochiai A, Sakuma T, Nishijima N, Gemma A, Asamura H, Nagai K, Yamada T.
- Journal Title
  
  Ann Oncol
  
  Volume: Oct;24(10): Issue: 10 Pages: 2594-600
- DOI
  10.1093/annonc/mdt293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-25461172, KAKENHI-PROJECT-25670868
[Journal Article] Activity of EGFR-tyrosine kinase and ALK inhibitors for EML4-ALK-rearranged non-small-cell lung cancer harbored coexisting EGFR mutation.2013
- Author(s)
  Miyanaga A, et al. 18人中14番目
- Journal Title
  
  BMC Cancer
  
  Volume: 13 Issue: 1 Pages: 262-262
- DOI
  10.1186/1471-2407-13-262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25250020, KAKENHI-PROJECT-25461172
[Journal Article] MiR-23a regulates TGF-β-induced epithelial-mesenchymal transition by targeting E-cadherin in lung cancer cells2012
- Author(s)
  Mengru C, Seike M, Soeno C, Mizutani H, Kitamura K, Minegishi Y, Noro R, Yoshimura A, Gemma A
- Journal Title
  
  Int J Oncol
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591008
[Journal Article] Enzastaurin has anti-tumour effects in lung cancers with overexpressed JAK pathway molecules2012
- Author(s)
  Shimokawa T, Seike M, Soeno C, Uesaka H, Miyanaga A, Mizutani H, Kitamura K, Minegishi Y, Noro R, Okano T, Yoshimura A, Gemma A
- Journal Title
  
  Br J Cancer
  
  Volume: 106(5) Issue: 5 Pages: 867-75
- DOI
  10.1038/bjc.2012.7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006, KAKENHI-PROJECT-21591008, KAKENHI-PROJECT-22590874
[Journal Article] Fatal Pneumonia Associated with Temozolomide Therapy in Patients with Malignant Glioma2012
- Author(s)
  Hayashi H, Saito Y, Kokuho N, Morimoto T, Kobayashi K, Tanaka T, Abe S, Fujita K, Azuma A, Gemma A
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: (Epub ahead of print) Issue: 7 Pages: 632-636
- DOI
  10.1093/jjco/hys058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006
[Journal Article] Quality of Life with Gefitinib in Patients with EGFR-Mutated Non-Small Cell Lung Cancer : Quality of Life Analysis of North East Japan Study Group 002 Trial2012
- Author(s)
  Oizumi S, Kobayashi K, Inoue A, Maemondo M, Sugawara S, Yoshizawa H, Isobe H, Harada M, Kinoshita I, Okinaga S, Kato T, Harada T, Gemma A, Saijo Y, Yokomizo Y, Morita S, Hagiwara K, Nukiwa T.
- Journal Title
  
  Oncologist
  
  Volume: 17 Issue: 6 Pages: 863-70
- DOI
  10.1634/theoncologist.2011-0426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006, KAKENHI-PROJECT-22790746, KAKENHI-PROJECT-24591156, KAKENHI-PROJECT-24591184, KAKENHI-PROJECT-24659396
[Journal Article] Fetal Heart Rate Classification Proposed by the Perinatology Committee of the Japan Society of Obstetrics and Gynecology: Reproducibility and Clinical Usefulness2012
- Author(s)
  Usuki J, Matsuda K, Azuma A, Kudoh S, Gemma A
- Journal Title
  
  Journal of Nippon Medical School
  
  Volume: 79 Issue: 1 Pages: 60-68
- DOI
  10.1272/jnms.79.60
- NAID
  130004147139
- ISSN
  1345-4676, 1347-3409
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006
[Journal Article] Reduction in serum high mobility group box-1 level by polymyxin B-immobilized fiber column in patients with idiopathic pulmonary fibrosis with acute exacerbation2011
- Author(s)
  Abe S, Hayashi H, Seo Y, Matsuda K, Kamio K, Saito Y, Usuki J, Azuma A, Kudo S, Gemma A
- Journal Title
  
  Blood Purif
  
  Volume: 32(4) 2 Issue: 4 Pages: 310-6
- DOI
  10.1159/000330325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006
[Journal Article] The safety and efficacy of weekly paclitaxel in combination with carboplatin for advanced non-small cell lung cancer with idiopathic interstitial pneumonias2011
- Author(s)
  Minegishi Y, Sudoh J, Kuribayasi H, Mizutani H, Seike M, Azuma A, Yoshimura A, Kudoh S, Gemma A
- Journal Title
  
  Lung Cancer
  
  Volume: 71(1) Issue: 1 Pages: 70-4
- DOI
  10.1016/j.lungcan.2010.04.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006
[Journal Article] Lung injury associated with bortezomib therapy in Japan2011
- Author(s)
  Mukai H, Ohyashiki K, Katoh T, Kusumoto M, Gemma A, Sakai H, Sugiyama Y, Hatake K, Fukuda Y, Kudoh S
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 52(12) Pages: 1859-69
- NAID
  10030462599
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006
[Journal Article] The feasibility study of Carboplatin plus Etoposide for advanced small cell lung cancer with idiopathic interstitial pneumonias2011
- Author(s)
  Minegishi Y, Kuribayashi H, Kitamura K, Mizutani H, Kosaihira S, Okano T, Seike M, Azuma A, Yoshimura A, Kudoh S, Gemma A
- Journal Title
  
  J Thorac Oncol
  
  Volume: 6(4) Issue: 4 Pages: 801-7
- DOI
  10.1097/jto.0b013e3182103d3c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006, KAKENHI-PROJECT-22590874
[Journal Article] Low-dose gefitinib treatment for patients with advanced non-small cell lung cancer harboring sensitive epidermal growth factor receptor mutations2011
- Author(s)
  Satoh H, Inoue A, Kobayashi K, Maemondo M, Oizumi S, Isobe H, Gemma A, Saijo Y, Yoshizawa H, Hagiwara K, Nukiwa T
- Journal Title
  
  J Thorac Oncol
  
  Volume: 6(8) Issue: 8 Pages: 1413-7
- DOI
  10.1097/jto.0b013e31821d43a8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006, KAKENHI-PROJECT-22659160, KAKENHI-PROJECT-22790746
[Journal Article] Clarification of clinical features of interstitial lung disease induced by irinotecan based on postmarketing surveillance data and spontaneous reports2011
- Author(s)
  Yoshii N, Suzuki T, Nagashima M, Kon A, Kakihata K, Gemma A
- Journal Title
  
  Anticancer Drugs
  
  Volume: 22(6) Issue: 6 Pages: 563-8
- DOI
  10.1097/cad.0b013e3283473f28
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006
[Journal Article] Frequency of and variables associated with the EGFR mutation and its subtypes2010
- Author(s)
  Tanaka T, Matsuoka M, Sutani A, Gemma A, Maemondo M, Inoue A, Okinaga S, Nagashima M, Oizumi S, Uematsu K, Nagai Y, Moriyama G, Miyazawa H, Ikebuchi K, Morita S, Kobayashi K, Hagiwara K
- Journal Title
  
  Int J Cancer
  
  Volume: 126(3) Issue: 3 Pages: 651-5
- DOI
  10.1002/ijc.24746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006
[Journal Article] HSP27 modulates epithelial to mesenchymal transition of lung cancer cells in a Smad-independent manner2010
- Author(s)
  Mizutani H, Okano T, Minegishi Y, Matsuda K, Sudoh J, Kitamura K, Noro R, Soeno C, Yoshimura A, Seike M, Gemma A
- Journal Title
  
  Oncology Letter
  
  Volume: 1 Issue: 6 Pages: 1011-1016
- DOI
  10.3892/ol.2010.190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591008
[Journal Article] North-East Japan Study Group. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR2010
- Author(s)
  Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, Fujita Y, Okinaga S, Hirano H, Yoshimori K, Harada T, Ogura T, Ando M, Miyazawa H, Tanaka T, Saijo Y, Hagiwara K, Morita S, Nukiwa T
- Journal Title
  
  N Engl J Med
  
  Volume: 362(25) Issue: 25 Pages: 2380-8
- DOI
  10.1056/nejmoa0909530
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006, KAKENHI-PROJECT-22659160
[Journal Article] Neutrophil adsorption by polymyxin B-immobilized fiber column for acute exacerbation in patients with interstitial pneumonia : a pilot study2010
- Author(s)
  Abe S, Seo Y, Hayashi H, Matsuda K, Usuki J, Azuma A, Kudoh S, Gemma A
- Journal Title
  
  Blood Purif
  
  Volume: 29(4) Issue: 4 Pages: 321-6
- DOI
  10.1159/000287232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006
[Journal Article] Histone deacetylase inhibitor enhances sensitivity of non-small-cell lung cancer cells to 5-FU/S-1 via down-regulation of thymidylate synthase expression and up-regulation of p21(waf1/cip1) expression2010
- Author(s)
  Noro R, Miyanaga A, Minegishi Y, Okano T, Seike M, Soeno C, Kataoka K, Matsuda KYoshimura A, Gemma A
- Journal Title
  
  Cancer Sci
  
  Volume: 101(6) Issue: 6 Pages: 1424-30
- DOI
  10.1111/j.1349-7006.2010.01559.x
- NAID
  10026593453
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006
[Journal Article] Phase I/II study of docetaxel and S-1, an oral fluorinated pyrimidine, for untreated advanced non-small cell lung cancer2010
- Author(s)
  Takiguchi Y, Tada Y, Gemma A, Kudoh S, Hino M, Yoshimori K, Yoshimura A, Nagao K, Niitani H
- Journal Title
  
  Lung Cancer
  
  Volume: 68(3) Issue: 3 Pages: 409-14
- DOI
  10.1016/j.lungcan.2009.08.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006, KAKENHI-PROJECT-22590850
[Journal Article] Pooled analysis of S-1 trials in non-small cell lung cancer according to histological type2010
- Author(s)
  Yamamoto N, Yamanaka T, Ichinose Y, Kubota K, Sakai H, Gemma A, Saijo N, Fukuoka M, Niitani H
- Journal Title
  
  Anticancer Res, Erratum in : Anticancer Res
  
  Volume: 30(7), 30(9)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006
[Journal Article] Exacerbation of idiopathic interstitial pneumonias associated with lung cancer therapy.2009
- Author(s)
  Minegishi Y, Takenaka K, Mizutani H, Sudoh J, Noro R, Okano T, Azuma A, Yoshimura A, Ando M, Tsuboi E, Kudoh S, Gemma A.
- Journal Title
  
  Intern Med. 48(9)
  
  Pages: 665-72
- NAID
  130000122480
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590919
[Journal Article] Exacerbation of Idiopathic Interstitial Pneumonias Associated with Lung Cancer Therapy2009
- Author(s)
  Minegishi Y, Takenaka K, Mizutani H, Sudoh J, Noro R, Okano T, Azuma A, Yoshimura A, Ando M, Tsuboi E, Kudoh S, Gemma A
- Journal Title
  
  Intern. Med.
  
  Volume: 48 Issue: 9 Pages: 665-672
- DOI
  10.2169/internalmedicine.48.1650
- NAID
  130000122480
- ISSN
  0918-2918, 1349-7235
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006
[Journal Article] North East Japan Gefitinib Study Group. First-line gefitinib for patients with advanced non-small-cell lung cancer harboring epidermal growth factor receptor mutations without indication for chemotherapy.2009
- Author(s)
  Inoue A, Kobayashi K, Usui K, Maemondo M, Okinaga S, Mikami I, Ando M, Yamazaki K, Saijo Y, Gemma A, Miyazawa H, Tanaka T, Ikebuchi K, Nukiwa T, Morita S, Hagiwara K
- Journal Title
  
  J Clin Oncol. 27(9)
  
  Pages: 1394-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590919
[Journal Article] MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers2009
- Author(s)
  Seike M, Goto A, Okano T, Bowman ED, Schetter AJ, Horikawa I, Mathe EA, Jen J, Yang P, Sugimura H, Gemma A, Kudoh S, Croce CM, Harris CC.
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 106(29) Issue: 29 Pages: 12085-90
- DOI
  10.1073/pnas.0905234106
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006
[Journal Article] Clinicopathological analysis of primary lung carcinoma with heterotopic ossification.2009
- Author(s)
  Kuribayashi H, Tsuta K, Mizutani E, Maeshima AM, Yoshida Y, Gemma A, Kudoh S, Asamura H, Matsuno Y
- Journal Title
  
  Lung Cancer. 64(2)
  
  Pages: 160-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590919
[Journal Article] Phase II study of nimustine hydrochloride(ACNU) plus paclitaxel for refractory small cell lung cancer2009
- Author(s)
  Isobe K, Kobayashi K, Kosaihira S, Kurimoto F, Sakai H, Uchida Y, Nagai Y, Yamaguchi T, Miyanaga A, Ando M, Mori G, Hino M, Gemma A
- Journal Title
  
  Lung Cancer
  
  Volume: 66(3) Issue: 3 Pages: 350-4
- DOI
  10.1016/j.lungcan.2009.03.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591006
[Journal Article] Antitumor activity of histone deacetylase inhibitors in non-small cell lung cancer cells : development of a molecular predictive model.2008
- Author(s)
  Miyanaga A, Gemma A, Noro R, Kataoka K, Matsuda K, Nara M, Okano T, Seike M, Yoshimura A, Kawakami A, Uesaka H, Nakae H, Kudoh S.
- Journal Title
  
  Mol Cancer Ther.
  
  Pages: 1923-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590919
[Journal Article] Predominant infiltration of macrophages and CD8(+)T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer.2008
- Author(s)
  Kawai O, Ishii G, Kubota K, Murata Y, Naito Y, Mizuno T, Aokage K, Saijo N, Nishiwaki Y, Gemma A, Kudoh S, Ochiai A.
- Journal Title
  
  Cancer 113(6)
  
  Pages: 1387-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590919
[Journal Article] PTEN inactivation in lung cancercells and the effect of its recovery on treatment with epidermal growth factor receptor tyrosine kinase inhibitors.2007
- Author(s)
  Noro R, Gemma A, Miyanaga A, Kosaihira S, Minegishi Y, Nara M, Kokubo Y, Seike M, Kataoka K, Matsuda K, Okano T, Yoshimura A, Kudoh S.
- Journal Title
  
  Int J Oncol. 31(5)
  
  Pages: 1157-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590919
[Journal Article] Use of a cytokine gene expression signature in lung adenocarcinoma and the surrounding tissue as a prognostic classifier.2007
- Author(s)
  Seike M, Yanaihara N, Bowman ED, Zanetti KA, Budhu A, Kumamoto K, Mechanic LE, Matsumoto S, Yokota J, Shibata T, Sugimura H, Gemma A, Kudoh S, Wang XW, Harris CC.
- Journal Title
  
  J Natl Cancer Inst 99(16)
  
  Pages: 1257-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590919
[Journal Article] Gemcitabine resistance in a highly metastatic subpopulation of a pulmonary adenocarcinoma cell line resistant to gefitinib.2007
- Author(s)
  Takemura A, Gemma A, Shibuya M, Matsuda K, Okano T, Nara M, Noro R, Minegishi Y, Yoshimura A, Kudoh S.
- Journal Title
  
  Int J Oncol. 31(6)
  
  Pages: 1325-32
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590919
[Journal Article] In vitro simulation study of individualized chemotherapy in lung cancer.2007
- Author(s)
  Li C, Gemma A, Minegishi Y, Matsuda K, Seike Y, Noro R, Shionoya A, Kawakami A, Ogawa N, Kudoh S
- Journal Title
  
  J Nippon Med Sch. 74(3)
  
  Pages: 217-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590919
[Journal Article] Anticancer drug clustering in lung cancer based on gene expression profiles and sensitivity database2006
- Author(s)
  Akihiko, Gemma, et. al.
- Journal Title
  
  BMC Cancer 6
  
  Pages: 174-174
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590869
[Journal Article] Anticancer drug clustering in lung cancer based on gene expression profiles and sensitivity database2006
- Author(s)
  Akihiko Gemma, et. al.
- Journal Title
  
  BMC Cancer 6
  
  Pages: 174-174
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590869
[Journal Article] Anticancer drug clustering in lung cancer based on gene expression profiles and sensitivity database.2006
- Author(s)
  Akihiko Gemma et al.
- Journal Title
  
  BMC Cancer, 6
  
  Pages: 174-174
- Data Source
  KAKENHI-PROJECT-18590869
[Journal Article] Mutational analysis of the macrophage scavenger receptor 1(MSR1) gene in primary lung cancer.2004
- Author(s)
  Yoshimura A, Gemma A, Kataoka K, Hosoya Y, Noro R, Seike M, Kokubo Y, Watanabe M, Kudoh S.
- Journal Title
  
  J Nippon Med Sch. 71(2)
  
  Pages: 99-104
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590831
[Presentation] PRMT5 Mediated Gli1 Activation Pathway Maintains Cancer Stem Cells in Non-Small Cell Lung Cancer.2018
- Author(s)
  Yoshinori Abe, Susumu Takeuchi, Masahiko Seike, Akihiko Gemma, Nobuyuki Tanaka
- Organizer
  The 6th JCA-AACR Special Joint Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04054
[Presentation] miR-23aはSmad依存的にTGFβ誘導上皮間葉移行(EMT)を制御する2011
- Author(s)
  清家正博、野呂林太郎、峯岸裕司、添野千絵、吉村明修、弦間昭彦
- Organizer
  第70回日本癌学会総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21591008
[Presentation] 薬剤性間質性肺炎の管理2010
- Author(s)
  弦間昭彦
- Organizer
  日本臨床腫瘍学会
- Place of Presentation
  東京
- Year and Date
  2010-03-19
- Data Source
  KAKENHI-PROJECT-21591006
[Presentation] Gene expression profiles in lung cancer cells cooperated with drug sensitivity to PKC inhibitor enzastaurin2010
- Author(s)
  Seike M, Smimokawa T, Soeno C, Okano T, Minegishi Y, Yoshimura A and Gemma A
- Organizer
  101st AACR Annual Meeting
- Place of Presentation
  Washington DC
- Year and Date
  2010-04-06
- Data Source
  KAKENHI-PROJECT-21591008
[Presentation] 肺がん細胞の薬剤感受性に関与するマイクロRNA発現プロファイル2010
- Author(s)
  清家正博、岡野哲也、添野千絵、峯岸裕司、野呂林太郎、吉村明修、弦間昭彦
- Organizer
  第69回日本癌学会総会
- Place of Presentation
  大阪
- Year and Date
  2010-10-24
- Data Source
  KAKENHI-PROJECT-21591008
[Presentation] MicroRNA expression profiles modulate the drug sensitivity of lung cancer cells2009
- Author(s)
  Seike M, Noro R, Soeno C, Shimokawa T, Miyanaga A, Yoshimura A and Gemma A
- Organizer
  100th AACR Annual Meeting
- Place of Presentation
  Denver
- Year and Date
  2009-04-19
- Data Source
  KAKENHI-PROJECT-21591008
[Presentation] 非喫煙者肺癌およびEGFR-TKI感受性に関与するmiR-21の役割2009
- Author(s)
  清家正博、岡野哲也、吉村明修、弦間昭彦
- Organizer
  第68回日本癌学会総会
- Year and Date
  2009-10-02
- Data Source
  KAKENHI-PROJECT-21591008
[Presentation] 非喫煙者肺癌およびEGFR-TKI感受性に関与するmiR-21の役割2009
- Author(s)
  清家正博、岡野哲也、吉村明修、弦間昭彦
- Organizer
  第50回日本肺癌学会総会
- Year and Date
  2009-11-13
- Data Source
  KAKENHI-PROJECT-21591008
[Presentation] 抗癌剤のリスクとベネフィットーイレッサを中心に2007
- Author(s)
  弦間昭彦
- Organizer
  特別シンポジウム「呼吸器領域におけるリスクアセスメントとリスクコミュニケーション」第47回日本呼吸器学会
- Data Source
  KAKENHI-PROJECT-19590919
[Presentation] (in Japanese)2006
- Author(s)
  Akihiko, Gemma, et. al.
- Organizer
  Japan LCS
- Place of Presentation
  Tokyo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590869
[Presentation] TS-1特定使用成績調査(間質性肺炎)の検討結果について2006
- Author(s)
  弦間昭彦
- Organizer
  第44回日本癌治療学会総会
- Place of Presentation
  東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590869

1. KUDOH Shoji (40256912)

# of Collaborated Projects: 8 results

# of Collaborated Products: 9 results
2. SEIKE Masahiro (30366687)

# of Collaborated Projects: 6 results

# of Collaborated Products: 30 results
3. SHIBUYA Masahiko (50142534)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. UEMATSU Kazutsugu (10297880)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. OKANO Tetsuya (00339376)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. MINEGISHI Yuji (80386234)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
7. TANAKA Nobuyuki (80222115)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
8. MIYANAGA AKIHIKO (00591281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. YAMADA Tesshi (30221659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. AOYAMA Akinori (60089688)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. YOSHIMURA Akinobu (00230805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 清水幹容 (00774358)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 竹中圭

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. YOSHIZAWA Hirohisa

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. OIZUMI Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. TAKIGUCHI Yuuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. NAITO Zenya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. ISHIWATA Toshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
19. MATSUDA Yoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. WATANABE Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 前門戸任

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
22. 本田一文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 岩澤俊一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 功刀しのぶ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Gemma Akihiko 弦間 昭彦

GENMA Akihiko 弦間 昭彦

GEMMA Akihiko 弦間 昭彦

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Finishing blow therapy in lung cancer with driver gene mutationPrincipal Investigator

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Development of molecular predictive model for molecular targeted therapy in lung cancer using pathway analysisPrincipal Investigator

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Identification of chemosensitivity predictive factors in lung cancer cells and chemosensitivity prediction by imagePrincipal Investigator

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The mechanisms of highly metastetic capasity in highly metastatic subpopulations of lung adenocarcinoma cell line and these clinical applicationsPrincipal Investigator

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The mechanisms of the highly metastatic property using human lung cancer sublines with highly metastatic potential established and the expolation of the molecular targets for lung cancer therapyPrincipal Investigator

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Study of mechanisms of the highly metastatic feature using human lung cancer sublines with highly metastatic property establishedPrincipal Investigator

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Gemma Akihiko 弦間昭彦

GENMA Akihiko 弦間昭彦

GEMMA Akihiko 弦間昭彦

[Book] 呼吸器疾患診療　最新ガイドライン2014