Hiroi Tomoko 廣井朋子

… Alternative Names

廣井朋子ヒロイトモコ

HIROI Tomoko 廣井朋子

Less

Researcher Number	20238398
Other IDs
External Links
Affiliation (Current)	2025: 聖マリアンナ医科大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 聖マリアンナ医科大学, 医学研究科, 講師 2006 – 2007: St. Marianna University School of Medicine, Department of Medicine, Lecturer, 医学部, 講師 2004 – 2005: 聖マリアンナ医科大学, 医学部, 助手 1998 – 2002: 聖マリアンナ医科大学, 医学部, 助手 1993 – 1994: 聖マリアンナ医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator 動物生理・代謝 / Medium-sized Section 63:Environmental analyses and evaluation and related fields / Medium-sized Section 51:Brain sciences and related fields Except Principal Investigator Psychiatric science / Psychiatric science / Basic Section 30010:Crystal engineering-related
Keywords	Principal Investigator 副腎皮質 / ミトコンドリア / ATP依存性プロテアーゼ / リアルタイムPCR / 放射線影響 / 内部被ばく / ハウスキーピング遺伝子 / DNAトランスフェクション / リアルタイムRT-PCR / 中枢型トリプトファン水酸化酵素 … More / TPH2 / 翻訳抑制 / エクソン・スキップ / 活性酸素 / Thioredoxin reductase / Alkyl hydroperoxide reductase / 酸化ストレス / cDNA / システイン … More Except Principal Investigator CREB / AP-2 / NF-Y / 選択的スプライシング / 脱溶媒和 / 分子動力学 / 脱水和 / 放射性同位元素 / RI実験 / 結晶成長 / MDシミュレーション / Histone deacetylase / Neuron-restrictive silencer element / Neuron-restrictive silencer factor / Rat serotonergic cell line RN46A / Transcriptional regulation region / Tryptophan hydroxylase 1 / Tryptophan hydroxylase 2 / セロトニン系神経細胞特異的転写因子 / ラット縫線由来RN46A細胞 / ヒト抹消型トリプトファン水酸化酵素 / ヒト脳型トリプトファン水酸化酵素 / セロトニン神経特異的転写因子 / ヒト神経芽細胞腫SH-SY5Y細胞 / ヒト肺小細胞癌HSP-77細胞 / ヒストンデアセチラーゼ / 神経特異的抑制配列 / 神経特異的抑制因子 / ラット縫線核由来RN46A細胞 / 転写制御領域 / トリプトファン水酸化酵素1 / トリプトファン水酸化酵素2 / Antidepressant / Transcriptional repression / Glucocorticoid receptor / β1-adrenergic receptor / デキサメサゾン / β1アドレナリン受容体遺伝子 / 抗うつ薬 / 転写抑制 / グルココルチコイド受容体 / β_1アドレナリン受容体遺伝子 / アデニル酸シクラーゼ / セロトニン4L受容体 / セロトニン4S受容体 / セロトニン受容体 / 5-HT_4受容体遺伝子 / 5-HT_4受容体 / 2'-0-Met RNA / モルフォリノオリゴヌクレオチド / エクソンスプライシング抑制配列 / エクソンスプライシング促進配列 / エクソンスキッピング / βアミロイド蛋白質前駆体遺伝子 / アルツハイマー病 Less

放射性同位元素標識プラスミドを用いた低線量内部被ばく影響の数値化Principal Investigator
- Principal Investigator
  
  廣井朋子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 63:Environmental analyses and evaluation and related fields
- Research Institution
  St. Marianna University School of Medicine
結晶成長における脱水和・脱溶媒和の影響
- Principal Investigator
  
  大滝正訓
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 30010:Crystal engineering-related
- Research Institution
  St. Marianna University School of Medicine
Removal of translation repression of tryptophan hydroxylase 2 and drug discovery by exon skipping strategyPrincipal Investigator
- Principal Investigator
  
  Hiroi Tomoko
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 51:Brain sciences and related fields
- Research Institution
  St. Marianna University School of Medicine
アルツハイマー病新規治療戦略:前駆体遺伝子エクソン17破断によるAβ生成抑制機構
- Principal Investigator
  
  MATSUI Hiroaki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  St.Marianna University School of Medicine
Structural, functional and pormorphic analysis of the regulatory regions necessary for the expression of the human neuronal tryptophan hydroxylase gene.
- Principal Investigator
  
  MATSUI Hiroaki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  St. Marianna University School of Medicine
The transcriptional regulation of the human β1-adrenergic receptor gene by stress-related transcription molecules
- Principal Investigator
  
  MATSUI Hiroaki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  St. Marianna University School of Medicine
アデニル酸シクラーゼ促進性ヒト5-HT4受容体の遺伝子構造ならびに機能調節機構
- Principal Investigator
  
  松井宏晃
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  St. Marianna University School of Medicine
ミトコンドリアATP依存性プロテアーゼの特異的基質SP-22の調節と生理機能Principal Investigator
- Principal Investigator
  
  廣井朋子
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  動物生理・代謝
- Research Institution
  St. Marianna University School of Medicine
ミトコンドリアATP依存性プロテアーゼの特異的基質SP25の細胞における分化役割-ヒト赤白血病細胞およびマウス副腎皮質培養細胞株Y-1におけるcDNAクローニングおよび発現調節Principal Investigator
- Principal Investigator
  
  廣井朋子
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  動物生理・代謝
- Research Institution
  St. Marianna University School of Medicine

All 2023 2021 2008 2005 2004

All Journal Article Presentation

[Journal Article] Regulation of the tryptophan hydroxylase-2 gene promoter activity in immortalized serotonergic RN46A cells.2008
- Author(s)
  Tomoko Hiroi
- Journal Title
  
  Fundamental Clinical Pharmacology 22(Suppl. 2)
  
  Pages: 124-125
- Data Source
  KAKENHI-PROJECT-19659294
[Journal Article] 放射性同位元素定期教育訓練時のアンケート結果の解析2005
- Author(s)
  廣井朋子ら
- Journal Title
  
  日本放射線安全管理学会誌 4(1)
  
  Pages: 50-53
- Data Source
  KAKENHI-PROJECT-16591170
[Journal Article] Regulation of the basic promoter activity of the human 5-HT4 receptor gene by Sp family transcription factors in human neuroblastoma SY5Y cells2004
- Author(s)
  T.Hiroi et al.(7名)
- Journal Title
  
  Fundamental ＆ Clinical Pharmacology 18
  
  Pages: 146-146
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591170
[Journal Article] Regulation of the basic promoter activity of the human 5-HT4 receptor gene by Sp family transcription factors in human neuroblastoma SY5Y cells.2004
- Author(s)
  T.Hiroi et al.
- Journal Title
  
  Fundamental ＆ Clinical Pharmacology 18
  
  Pages: 146-146
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591170
[Presentation] 標識化合物の放射線が遺伝子発現量測定の実験系に寄与する割合2023
- Author(s)
  大滝正訓, 廣井朋子, 立浪忍, 小林司, 太田有紀, 武半優子, 木田圭亮, 飯利太朗, 佐藤知雄, 松本直樹
- Organizer
  日本放射線安全管理学会第 22 回学術大会
- Data Source
  KAKENHI-PROJECT-20K05350
[Presentation] 標識化合物の放射線が遺伝子発現量測定の実験系に寄与する割合2023
- Author(s)
  大滝正訓、廣井朋子、立浪忍、小林司、太田有紀、武半優子、木田圭亮、飯利太朗、佐藤知雄、松本直樹
- Organizer
  日本放射線安全管理学会第22回学術大会
- Data Source
  KAKENHI-PROJECT-22K19852
[Presentation] ヒト中枢型トリプトファン水酸化酵素(TPH2)のexon 3には75塩基対の翻訳抑制配列が存在する2023
- Author(s)
  廣井朋子
- Organizer
  日本薬学会第147年会
- Data Source
  KAKENHI-PROJECT-19K22581
[Presentation] 培養細胞におけるハウスキーピング遺伝子発現量に対するＲＩ標識化合物の影響2023
- Author(s)
  廣井朋子、金子英恵、大滝正訓、那和雪乃、坪野谷真朗、立浪忍、松本直樹、佐藤知雄
- Organizer
  日本放射線安全管理学会第22回学術大会
- Data Source
  KAKENHI-PROJECT-22K19852
[Presentation] トリチウム水を用いた蒸気拡散法における水分子の定量的評価2021
- Author(s)
  ○大滝正訓, 廣井朋子, 太田有紀, 武半優子, 渡辺実, 小林司, 木田圭亮, 飯利太朗, 佐藤知雄, 松本直樹
- Organizer
  第３回日本放射線安全管理学会・日本保健物理学会合同大会
- Data Source
  KAKENHI-PROJECT-20K05350
[Presentation] Structure prediction of the N-terminal regulatory domain of the human tryptophan hydroxylase 22021
- Author(s)
  Ootaki Masanori, Hiroi Tomoko, Ohta Yuki, Takeba Yuko, Kida Keisuke, Matsui Hiroaki, Naoki Matsumoto
- Organizer
  第94回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K05350

1. MATSUI Hiroaki (90181685)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. 大滝正訓 (20612683)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
3. ASAKURA Mikio (70103504)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 那和雪乃 (10549786)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. OSADA Kenichi (20233504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 長谷川浩 (80288183)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 伊野美幸 (20203218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 太田有紀 (60387066)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. 立浪忍 (70197383)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Hiroi Tomoko 廣井 朋子

廣井 朋子 ヒロイ トモコ

HIROI Tomoko 廣井 朋子

Research Projects

Research Products

Co-Researchers

放射性同位元素標識プラスミドを用いた低線量内部被ばく影響の数値化Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

結晶成長における脱水和・脱溶媒和の影響

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Removal of translation repression of tryptophan hydroxylase 2 and drug discovery by exon skipping strategyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アルツハイマー病新規治療戦略:前駆体遺伝子エクソン17破断によるAβ生成抑制機構

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural, functional and pormorphic analysis of the regulatory regions necessary for the expression of the human neuronal tryptophan hydroxylase gene.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The transcriptional regulation of the human β1-adrenergic receptor gene by stress-related transcription molecules

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アデニル酸シクラーゼ促進性ヒト5-HT4受容体の遺伝子構造ならびに機能調節機構

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ミトコンドリアATP依存性プロテアーゼの特異的基質SP-22の調節と生理機能Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ミトコンドリアATP依存性プロテアーゼの特異的基質SP25の細胞における分化役割-ヒト赤白血病細胞およびマウス副腎皮質培養細胞株Y-1におけるcDNAクローニングおよび発現調節Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Regulation of the tryptophan hydroxylase-2 gene promoter activity in immortalized serotonergic RN46A cells.2008

Author(s)

Journal Title

Data Source

[Journal Article] 放射性同位元素定期教育訓練時のアンケート結果の解析2005

Author(s)

Journal Title

Data Source

[Journal Article] Regulation of the basic promoter activity of the human 5-HT4 receptor gene by Sp family transcription factors in human neuroblastoma SY5Y cells2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Regulation of the basic promoter activity of the human 5-HT4 receptor gene by Sp family transcription factors in human neuroblastoma SY5Y cells.2004

Author(s)

Journal Title

Description

Data Source

[Presentation] 標識化合物の放射線が遺伝子発現量測定の実験系に寄与する割合2023

Author(s)

Hiroi Tomoko 廣井朋子

廣井朋子ヒロイトモコ

HIROI Tomoko 廣井朋子

[Presentation] ヒト中枢型トリプトファン水酸化酵素(TPH2)のexon 3には75塩基対の翻訳抑制配列が存在する2023