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Shin-ya Kazuo  新家 一男

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SHIN-YA Kazuo  新家 一男

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Researcher Number 20251481
Other IDs
Affiliation (Current) 2025: 国立研究開発法人産業技術総合研究所, 生命工学領域, 副研究部門長
Affiliation (based on the past Project Information) *help 2023 – 2024: 国立研究開発法人産業技術総合研究所, 生命工学領域, 総括研究主幹
2022 – 2023: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究副部門長
2017 – 2023: 国立研究開発法人産業技術総合研究所, 生命工学領域, 研究グループ長
2016: 国立研究開発法人産業技術総合研究所, その他部局等, 研究員
2015: 国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 上級主任研究員 … More
2014: 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 上級主任研究員
2013: 独立行政法人産業技術総合研究所, バイオメディカル研究部門, 研究グループ長
2012: 独立行政法人産業技術総合研究所, バイオメディシナル情報研究センター, 上級主任研究員
2008 – 2011: National Institute of Advanced Industrial Science and Technology, バイオメディシナル情報研究センター, 主任研究員
2008: 独立行政法人産業技術総合研究所, 生物情報解析研究センター, 主任研究員
2006 – 2008: 産業技術総合研究所, 生物情報解析研究センター, 主任研究員
2006 – 2007: 産業総合技術研究所, 生物情報解析センター, チームリーダー
2004 – 2005: 東京大学, 分子細胞生物学研究所, 助手
2001 – 2002: 東京大学, 分子細胞生物学研究所, 助手
1994 – 1999: 東京大学, 分子細胞生物学研究所, 助手
1997: Tokyo Univ.Inst.of Mol and Cell., Assistant Prof., 分子細胞生物学研究所, 助教授 Less
Review Section/Research Field
Principal Investigator
Bioproduction chemistry/Bioorganic chemistry / Bioproduction chemistry/Bioorganic chemistry / Broad Section F / Medium-sized Section 37:Biomolecular chemistry and related fields / Biological Sciences
Except Principal Investigator
Bioproduction chemistry/Bioorganic chemistry / Basic Section 40040:Aquatic life science-related / Applied molecular and cellular biology / Drug development chemistry / Science and Engineering
Keywords
Principal Investigator
kaitocephalin / グルタミン酸毒性 / 天然化合物 / AMPA / 脳虚血疾患 / halxazone / NMDA / スクリーニング / 海馬神経細胞 / 天然物化学 … More / バイオものづくり / 放線菌 / ポリケタイド / 化合物ライブラリー / コンビナトリアル生合成 / 構造生物学 / 合成生物学 / 異種発現生産 / 難培養性微生物 / 異種発現解析 / 異種発現 / メタゲノミクス / 海洋生物 / 生合成遺伝子 / 難培養微生物 / oxidative stress / ER STRESS / neuro-protective substances / Alzheimer / Parkinson / versipelostatin / 抗酸化活性 / L-DOPA / Halxazone / Par-4 / PC12細胞 / 中枢神経疾患 / アポトーシス / パーキソン病 / 酸化ストレス / ERストレス / 神経保護物質 / アルツハイマー病 / パーキンソン病 / versipelostain / CaィイD12+ィエD1 influx / slice culture / hippocampus / kainate / brain ischemia / ラット海馬神経細胞 / Kaitocephalin / Ca^<2+> / 海馬スライス / カイニン酸 / 脳卒中 / sphere特異的細胞死 / sphere形成 / がん幹細胞 / 膠芽腫グリオブラストーマ / 相同組み換え / スプライソソーム / マイトトキシン / 代謝拮抗剤 / 発がんプロモーター / マクロライド系化合物 / 抗腫瘍物質 / p27癌抑制遺伝子 / スプラシング阻害 / 天然物 / 抗がん剤 / スプライシング / 遺伝子組み換え / 遺伝子修復 / オキサゾール環 / ALT / リアゾリン環 / 細胞老化 / G-quadruplex / テロメラーゼ / テロメア / Telomestatin / KAアンタゴニスト / 4-demethoxymichigazone / lavanduquinocin / aestivophoenin / 微生物代謝産物 / 神経細胞 … More
Except Principal Investigator
BE-40644 / TANGO-HMBC / 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol / 3-hydroxy-3-methylglutaryl coenzyme A reductase / 2-C-methyl-D-erythritol 2,4-cyclodiphosphate / novobiocin / HMG CoA reductase / carquinostatin / longestin / 非メバロン酸経路 / メバロン酸経路 / D-HMBC / decoupled-HMBC / グルタミン酸レセプター / 難培養微生物 / メタゲノミクス / 共生微生物 / 海綿 / 生合成遺伝子 / 海洋天然物 / メタゲノム / 異種発現生産 / 細胞分化調節 / X線結晶構造解析 / 分子間相互作用 / 合成致死遺伝子 / エピジェネティクス / 標的分子 / 天然生理活性物質 / nonmevalonate pathway / mevalonate pathway / 1- deoxyxylulose 5-phosphate reductoisomerase / 2-phospho-4-(cytidine 5' -diphospho)-2-C-methyl-D-erythritol / 2-C-methyl-D-erythritol 4-phosphate / 1-deoxyxylulose 5-phosphate reductoisomerase / 2-C-methylerythritol / ノボビオシン / 1-deoxyxylulose / 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol / 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase / 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase / 2-C-methyl-D-erythriitol 4-phosphate / 1-deoxyxylulose5-phosphate reductoisomerase / 2-phospho-4-(cytidine5'-diphospho)-2-C-methyl-D-erythritol / 4-(cytidine5'-diphospho)-2-C-methyl-D-erythritol / 2-C-methyl-D-erythritol4-phosphate / 3-hydroxy-3-methylglutaryl coezyme A reductase / Streptomyces aureouvifer / HMG Co-A reductase / non-mevalonate pathway / ロンゲスチンの生合成研究 / Streptomyces argenteolus / メナキノンの生合成 / ナフテルピンの生合成 / Streptomyces aeriouvifer / HMG CoAreducatase / Streptomyces aeriouvider / テルペノイド化合物の生合成 / BE-40644の生合成 / naphterpin / analysis of stereo-structures by computer calculation / MolSkop / コンピュータによる立体構造解析 / セコスリキサイド / ゲニンチオシン / プロモチオシン / スタキボシン / プロモインドシン / コンピューターによる立体構造解析 / モルスコープ / チオアミド / がん遺伝子 / アデノウイルス / アポトーシス / 呼吸阻害剤 / 固形癌 / Tolypocladium / prunustatin A / レポーターアッセイ / 構造活性相関 / 立体異性体 / tyroscherin / IGF / ammocidin / thioviridamide / efrapeptin / piericidin / versipelostatin / アデノウイルスがん遺伝子 / GRP78 / 分子シャペロン / 小胞体ストレス / アンダゴニスト / 立体選択的合成 / アンタゴニスト / カイトセファリン / 神経細胞毒性 / グルタミンレセプター / 神経細胞保護 / テロメア / テロメラーゼ / ビオチン化 / Telomestatin / Kaitocephalin Less
  • Research Projects

    (18 results)
  • Research Products

    (91 results)
  • Co-Researchers

    (22 People)
  •  Studies on innovative technology for modification of structural skeleton of natural products and production of artificial novel natural compoundsPrincipal Investigator

    • Principal Investigator
      新家 一男
    • Project Period (FY)
      2023 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section F
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  メタゲノミクスによる海綿における天然有機化合物生産機構の解明

    • Principal Investigator
      末永 光
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 40040:Aquatic life science-related
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Fermentative production of rare natural compounds found in marine organisms living in the seas of ThailandPrincipal Investigator

    • Principal Investigator
      新家 一男
    • Project Period (FY)
      2019 – 2024
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 37:Biomolecular chemistry and related fields
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Development of novel methods for target identification of natural products and chemical epigenetics

    • Principal Investigator
      Yoshida Minoru
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Applied molecular and cellular biology
    • Research Institution
      Institute of Physical and Chemical Research
  •  Studies on screening for substances which act on cancer stem cells established from tumors surgically excised from brain tumor patients.Principal Investigator

    • Principal Investigator
      SHIN-YA Kazuo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Studies on screening for bioactive compounds targeting gene repair, recombination and splicing systems.Principal Investigator

    • Principal Investigator
      SHINYA Kazuo
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      National Institute of Advanced Industrial Science and Technology
  •  Screening for microbial metabolites that regulate cellular stress response

    • Principal Investigator
      早川 洋一
    • Project Period (FY)
      2005 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Drug development chemistry
    • Research Institution
      Tokyo University of Science
  •  グルタミン酸毒性の発現・抑制機講解明を指向したカイトセファリンの合成と応用研究

    • Principal Investigator
      渡邉 秀典
    • Project Period (FY)
      2002 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Science and Engineering
    • Research Institution
      The University of Tokyo
  •  微生物由来のテロメラーゼ阻害物質telomestatinに関する研究Principal Investigator

    • Principal Investigator
      新家 一男
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  BIAcoreを用いた標識化低分子化合物をプローブとした複合タンパク質の探索研究

    • Principal Investigator
      HAYAKAWA Yoichi
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      The University of Tokyo
  •  Studies on apoptosis regulators substances of microbial origin aiming at neuroprotectionPrincipal Investigator

    • Principal Investigator
      SHIN-YA Kazuo
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      The University of Tokyo
  •  Biosynthetic studies on terpenoids produced by Actinomycetes by focusing on the nonmevalonate pathway

    • Principal Investigator
      SETO Haruo
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      The University of Tokyo
  •  Studies on substances of microbial origin which protect central nervous systemPrincipal Investigator

    • Principal Investigator
      SHIN-YA Kazuo
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      The University of Tokyo
  •  微生物の生産する脳中枢神経細胞保護物質に関する研究Principal Investigator

    • Principal Investigator
      新家 一男
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      The University of Tokyo
  •  Biosynthetic Studies of terpenoids produced by actinomycetes

    • Principal Investigator
      SETO Haruo
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      The University of Tokyo
  •  脳中枢神経細胞保護物質の微生物からの探索研究Principal Investigator

    • Principal Investigator
      新家 一男
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      The University of Tokyo
  •  中枢神経細胞保護物質の微生物からの探索研究Principal Investigator

    • Principal Investigator
      新家 一男
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      The University of Tokyo
  •  DEVELOPMENT OF NEW NMR TECHNIQUES AND THEIR APPLICATION TO STRUCTURAL ANALYSIS OF NATURAL PRODUCTS

    • Principal Investigator
      SETO Haruo
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Bioproduction chemistry/Bioorganic chemistry
    • Research Institution
      INSTITUTE OF MOLECULAR AND CELLULAR BIOSCIENCES,UNIVERSITY OF TOKYO

All 2024 2023 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation

  • [Journal Article] Capability of a large bacterial artificial chromosome clone harboring multiple biosynthetic gene clusters for the production of diverse compounds2024

    • Author(s)
      Kudo Kei、Nishimura Takehiro、Izumikawa Miho、Kozone Ikuko、Hashimoto Junko、Fujie Manabu、Suenaga Hikaru、Ikeda Haruo、Satoh Nori、Shin-ya Kazuo
    • Journal Title

      The Journal of Antibiotics

      Volume: 77 Issue: 5 Pages: 288-298

    • DOI

      10.1038/s41429-024-00711-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-23H04569, KAKENHI-PROJECT-23H05474
  • [Journal Article] Pseudoalteropeptide A, a novel lipopeptide from the marine bacterium Pseudoalteromonas piscicida SWA4_PA4 isolated from marine seaweed2021

    • Author(s)
      Reiko Ueoka, Naoya Shinzato, Noritaka Kagaya, Hikaru Suenaga, Kazuo Shin-ya
    • Journal Title

      The Journal of Antibiotics

      Volume: 74 Issue: 2 Pages: 105-110

    • DOI

      10.1038/s41429-020-00377-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K23671, KAKENHI-PROJECT-20H03080
  • [Journal Article] Mechanism of Action of Prethioviridamide, an Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptide with a Polythioamide Structure2019

    • Author(s)
      Takase Shohei、Kurokawa Rumi、Kondoh Yasumitsu、Honda Kaori、Suzuki Takehiro、Kawahara Teppei、Ikeda Haruo、Dohmae Naoshi、Osada Hiroyuki、Shin-ya Kazuo、Kushiro Tetsuo、Yoshida Minoru、Matsumoto Ken
    • Journal Title

      ACS Chemical Biology

      Volume: 14 Issue: 8 Pages: 1819-1828

    • DOI

      10.1021/acschembio.9b00410

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K05366, KAKENHI-PLANNED-16H06447, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-26221204
  • [Journal Article] Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay2019

    • Author(s)
      Murashima Akihiro、Shinjo Keiko、Katsushima Keisuke、Onuki Tetsuo、Kondoh Yasumitsu、Osada Hiroyuki、Kagaya Noritaka、Shin-ya Kazuo、Kimura Hiroshi、Yoshida Minoru、Murakami Shingo、Kondo Yutaka.
    • Journal Title

      The Journal of Biochemistry

      Volume: - Issue: 1 Pages: 1-10

    • DOI

      10.1093/jb/mvz007

    • NAID

      40021952184

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H03582, KAKENHI-PROJECT-17K14995, KAKENHI-PROJECT-18K05366, KAKENHI-PLANNED-17H06412, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-26221204
  • [Journal Article] 1.Neothioviridamide, a Polythioamide Compound Produced by Heterologous Expression of a Streptomyces sp. Cryptic RiPP Biosynthetic Gene Cluster.2018

    • Author(s)
      Kawahara T, Izumikawa M, Kozone I, Hashimoto J, Kagaya N, Koiwai H, Komatsu M, Fujie M, Sato N, Ikeda H, Shin-Ya K.
    • Journal Title

      J. Nat. Prod.

      Volume: 81 Issue: 2 Pages: 264-269

    • DOI

      10.1021/acs.jnatprod.7b00607

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K07674, KAKENHI-PLANNED-16H06447, KAKENHI-PROJECT-26221204
  • [Journal Article] JBIR-150, a novel 20-membered polyene macrolactam from marine-derived Streptomyces sp. OPMA000712018

    • Author(s)
      Kawahara T, Fujiwara T, Kagaya N, Shin-ya K
    • Journal Title

      J. Antibiot.

      Volume: 71 Issue: 3 Pages: 390-392

    • DOI

      10.1038/s41429-017-0010-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26221204
  • [Journal Article] Novel arginine-containing peptides MBJ-0173 and MBJ-0174 from Mortierella alpina f28740.2017

    • Author(s)
      Kawahara T, Itoh M, Kozone I, Izumikawa M, Sakata N, Tsuchida T, Shin-ya K.
    • Journal Title

      J. Antibiot.

      Volume: 70 Issue: 2 Pages: 226-229

    • DOI

      10.1038/ja.2016.116

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221204
  • [Journal Article] JBIR-76 and JBIR-77, modified naphthoquinones from Streptomyces sp. RI-77.2016

    • Author(s)
      Motohashi K, Izumikawa M, Kagaya N, Takagi M, Shin-ya K.
    • Journal Title

      J. Antibiot.

      Volume: 69 Issue: 9 Pages: 707-708

    • DOI

      10.1038/ja.2015.135

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26221204
  • [Journal Article] MBJ-0110, a novel cyclopeptide isolated from the fungus Penicillium sp. f252672016

    • Author(s)
      Kawahara, T., Itoh, M., Kozone, I., Izumikawa, M., Sakata, N., Tsuchida, T., and Shin-ya, K.
    • Journal Title

      J. Antibiot.

      Volume: 69 Issue: 1 Pages: 66-68

    • DOI

      10.1038/ja.2015.78

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26221204
  • [Journal Article] Novel thioviridamide derivative-JBIR-140: heterologous expression of the gene cluster for thioviridamide biosynthesis.2015

    • Author(s)
      Izumikawa M, Kozone I, Hashimoto J, Kagaya N, Takagi M, Koiwai H, Komatsu M, Fujie M, Satoh N, Ikeda H, Shin-Ya K.
    • Journal Title

      The Journal of Antibiotics

      Volume: 印刷中 Issue: 8 Pages: 533-536

    • DOI

      10.1038/ja.2015.20

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25450112, KAKENHI-PROJECT-26221204
  • [Journal Article] Foxo3a Inhibitors of Microbial Origin, JBIR-141 and JBIR-1422015

    • Author(s)
      Teppei Kawahara, Noritaka Kagaya, Yuichi Masuda, Takayuki Doi, Miho Izumikawa, Kumiko Ohta, Atsushi Hirao, Kazuo Shin-ya
    • Journal Title

      Organic letters

      Volume: 17 Issue: 21 Pages: 5476-5479

    • DOI

      10.1021/acs.orglett.5b02842

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19548, KAKENHI-PROJECT-26850068, KAKENHI-PUBLICLY-15H01509, KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-15H02361
  • [Journal Article] Pyrrolidine-containing peptides, JBIR-126, -148 and -149, from Streptomyces sp. NBRC 1112282015

    • Author(s)
      Izumikawa, M., Kawahara, T., Kagaya, N., Yamamura, H., Hayakawa, M., Takagi, M., Yoshida, M., Doi, T., and Shin-ya, K.
    • Journal Title

      Tetrahedron Lett.

      Volume: 56 Issue: 39 Pages: 5333-5336

    • DOI

      10.1016/j.tetlet.2015.07.080

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26221204
  • [Journal Article] New hydroxamate metabolite, MBJ-0003, from Micromonospora2014

    • Author(s)
      Teppei Kawahara, Masashi Itoh, Miho Izumikawa, Ikuko Kozone, Noriaki Sakata, Toshio Tsuchida and Kazuo Shin-ya
    • Journal Title

      J. Antibiot

      Volume: 67 (3)(sp. 29867) Issue: 3 Pages: 261-263

    • DOI

      10.1038/ja.2013.124

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23380067
  • [Journal Article] New chaetoglobosin derivatives, MBJ-0038, MBJ-0039 and MBJ-0040, isolated from the fungus Chaetomium2013

    • Author(s)
      Teppei Kawahara, Masashi Itoh, Miho Izumikawa, Noriaki Sakata, Toshio Tsuchida and Kazuo Shin-ya
    • Journal Title

      J. Antibiot

      Volume: 66 (12)(sp. F24230) Issue: 12 Pages: 727-730

    • DOI

      10.1038/ja.2013.75

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23380067
  • [Journal Article] Cytotoxic sesquiterpenoids MBJ-0009 and MBJ-0010 from a saprobic fungus Nectria2013

    • Author(s)
      Teppei Kawahara, Masashi Itoh, Miho Izumikawa, Noriaki Sakata, Toshio Tsuchida and Kazuo Shin-ya
    • Journal Title

      J. Antibiot

      Volume: 66 (9)(sp. F26111) Issue: 9 Pages: 567-569

    • DOI

      10.1038/ja.2013.45

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23380067
  • [Journal Article] JBIR-129 and -139, cytotoxic 34-membered polyol macrolides of microbial origin2012

    • Author(s)
      Teppei Kawahara, Ji-Hwan Hwang, Miho Izumikawa, Junko Hashimoto, Motoki Takagi and Kazuo Shin-ya
    • Journal Title

      J. Nat. Prod

      Volume: 133 (10) Issue: 10 Pages: 1638-1641

    • DOI

      10.1021/np3004358

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23380067
  • [Journal Article] JBIR-137 and JBIR-138, new secondary metabolites from Aspergillus2012

    • Author(s)
      Teppei Kawahara, Aya Nagai, Motoki Takagi and Kazuo Shin-ya
    • Journal Title

      J. Antibiot

      Volume: 65 (10)(sp.fA75J) Issue: 10 Pages: 535-538

    • DOI

      10.1038/ja.2012.64

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23380067
  • [Journal Article] A new cyclizidine analog-JBIR-102-from Saccharopolyspora sp. RL78 isolated from mangrove soil2012

    • Author(s)
      Miho Izumikawa, Takahiro Hosoya, Motoki Takagi and Kazuo Shin-ya
    • Journal Title

      J. Antibiot

      Volume: 65 (1) Issue: 1 Pages: 41-43

    • DOI

      10.1038/ja.2011.99

    • NAID

      10030641114

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23380067
  • [Journal Article] Relative configuration of JBIR-129, a cytotoxic 34-membered glycosidic polyol macrolide from Streptomyces2012

    • Author(s)
      Teppei Kawahara, Miho Izumikawa Motoki Takagi and Kazuo Shin-ya
    • Journal Title

      Org. Lett

      Volume: 14 (17)(sp.RK74) Issue: 17 Pages: 4434-4437

    • DOI

      10.1021/ol301940q

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23380067
  • [Journal Article] New angucycline C-glycosides from Streptomyces2011

    • Author(s)
      Jun-ya Ueda, Miho Izumikawa, Akira Mukai, Aya Nagai, Ji-Hwan Hwang, Motoki Takagi and Kazuo Shin-ya
    • Journal Title

      J. Antibiot

      Volume: 64(5)(sp.RI33) Issue: 5 Pages: 367-372

    • DOI

      10.1038/ja.2011.8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23380067
  • [Journal Article] JBIR-97, -98 and -99, obtained from marine sponge-derived fungus Tritirachium sp.SpB081112MEf2.2010

    • Author(s)
      J.Ueda, M.Takagi, K.Shin-ya
    • Journal Title

      J.Antibiot.

      Volume: 63(10) Pages: 627-629

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] JBIR-69, a new peptide metabolite from Streptomyces sp.OG05.2010

    • Author(s)
      Takeshi Fujiwara, Aya Nagai, Motoki Takagi, Kazuo Shin-ya
    • Journal Title

      J.Antibiot. 63

      Pages: 95-96

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] Anti-influenza virus compound from Streptomyces sp.RI18.2010

    • Author(s)
      M.Takagi, K.Motohashi, A.Nagai, M.Izumikawa, M.Tanaka, S.Fuse, T.Doi, K.Iwase, A.Kawaguchi, K.Nagata, T.Takahashi, K.Shin-ya
    • Journal Title

      Org.Lett.

      Volume: 12(20) Pages: 4664-4666

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] A new angucycline and a new butenolide isolated from lichen-derived Streptomyces spp.2010

    • Author(s)
      Keiichiro Motohashi, Motoki Takagi, Hideki Yamamura, Masayuki Hayakawa, Kazuo Shin-ya.
    • Journal Title

      J.Antibiot. 63(9)

      Pages: 545-548

    • NAID

      10030710013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] New xanthoquinodin-like compounds, JBIR-97, -98 and -99, obtained from marine sponge-derived fungus Tritirachium sp.SpB081112MEf2.2010

    • Author(s)
      Jun-ya Ueda, Motoki Takagi, Kazuo Shin-ya
    • Journal Title

      J.Antibiot. 63(10)

      Pages: 615-618

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] JBIR-69, a new peptide metabolite from Streptomyces sp.OG05.2010

    • Author(s)
      Takeshi Fujiwara, Aya Nagai, Motoki Takagi, Kazuo Shin-ya.
    • Journal Title

      J.Antibiot. 63(2)

      Pages: 95-96

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] A new angucycline and a new butenolide isolated from lichen-derived Streptomyces spp.2010

    • Author(s)
      K.Motohashi, M.Takagi, H.Yamamura, M.Hayakawa, K.Shin-ya
    • Journal Title

      J.Antibiot.

      Volume: 63(9) Pages: 545-548

    • NAID

      10030710013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] JBIR-23 and -24, novel anticancer agents from Streptomyces sp. AK-AB272009

    • Author(s)
      K. Motohashi, J. -H. Hwang, M. Takagi, K Shin-ya
    • Journal Title

      Org. Lett. 11

      Pages: 285-288

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin.2009

    • Author(s)
      Junichi Matsuo, Yoshinori Tsukumo, Junko Sakurai, Satomi Tsukahara, Hae-Ryong Park, Kazuo Shin-ya, Toshiki Watanabe, Takashi Tsuruo, Akihiro Tomida.
    • Journal Title

      Cancer Sci. 100(2)

      Pages: 327-333

    • NAID

      10025142654

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] JBIR-52, a novel antimycin-like compound, from Streptomyces sp.ML552009

    • Author(s)
      Ikuko Kozone, Jun-ya Ueda, Motoki Takagi, Kazuo Shin-ya
    • Journal Title

      J.Antibiot. 62

      Pages: 593-595

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] New glycosylated derivatives of versipelostatin, the GRP78/Bip molecular chaperone down-regulator, from Streptomyces versipellis 4083-SVS62009

    • Author(s)
      P. Zhao, J. Ueda, I. Kozone, S. Chijiwa, M. Takagi, F. Kudo, M. Nishiyama, K. Shin-ya, T. Kuzuyama
    • Journal Title

      Org. Biomol. Chem. 7

      Pages: 1454-1460

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp2009

    • Author(s)
      Murakami, R., Shinozaki, J., Kajiura, T., Kozone, I., Takagi, M., Shin-ya, K., Seto, H., Hayakawa, Y.
    • Journal Title

      AJ9571. J. Antibiot. 62

      Pages: 123-127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390031
  • [Journal Article] JBIR-17, a novel trichostatin analogue from Streptomyces sp.26634.2009

    • Author(s)
      Jun-ya Ueda, Ji-Hwan Hwang, Taira Kato, Atsushi Ochiai, Kunio Isshiki, Motoki Takagi, Kazuo Shin-ya.
    • Journal Title

      J.Antibiot. 62(5)

      Pages: 283-285

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea.2009

    • Author(s)
      Takeshi Fujiwara, Ji-Hwan Hwang, Akihiko Kanamoto, Hiroshi Nagai, Motoki Takagi, Kazuo Shin-ya.
    • Journal Title

      J.Antibiot. 62(7)

      Pages: 393-395

    • NAID

      10030635826

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] New glycosylated derivatives of versipelostatin, the GRP78/Bipmolecular chaperone down-regulator, from Streptomyces versipellis 4083-SVS6.2009

    • Author(s)
      Ping Zhao, Jun-ya Ueda, Ikuko Kozone, Shuhei Chijiwa, Motoki Takagi,Fumitaka Kudo, Makoto Nishiyama, Kazuo Shin-ya, Tomohisa Kuzuyama.
    • Journal Title

      Org.Biomol.Chem. 7(7)

      Pages: 144-1460

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] JBIR-52, a novel antimycin-like compound, from Streptomyces sp.ML55.2009

    • Author(s)
      Ikuko Kozone, Jun-ya Ueda, Motoki Takagi, Kazuo Shin-ya.
    • Journal Title

      J.Antibiot. 62(10)

      Pages: 593-595

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] JBIR-23 and -24, novel anticancer agents from Streptomyces sp. AK-AB27.2009

    • Author(s)
      Keiichiro Motohashi, Ji-Hwan Hwang, Motoki Takagi, Kazuo Shin-ya.
    • Journal Title

      Org.Lett. 11(2)

      Pages: 285-288

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] JBIR-44, a new bromotyrosine compound from a marine sponge Psammaplysilla purpurea.2009

    • Author(s)
      Takeshi Fujiwara, Ji-Hwan Hwang, Akihiko Kanamoto, Hiroshi Nagai, Motoki Takagi, Kazuo Shin-ya
    • Journal Title

      J.Antibiot. 62

      Pages: 393-395

    • NAID

      10030635826

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] JBIR-17, a novel trichostatin analogue from Streptomyces sp.266342009

    • Author(s)
      Jun-ya Ueda, Ji-Hwan Hwang, Taira Kato, Atsushi Ochiai, Kunio Isshiki, Motoki Takagi, Kazuo Shin-ya
    • Journal Title

      J.Antibiot. 62

      Pages: 283-285

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] A novel versipelostatin analogue, versipelostatin F isolated from Streptomyces versipellis 4083-SVS6.2008

    • Author(s)
      Jun-ya Ueda, Shuhei Chijiwa, Motoki Takagi, Kazuo Shin-ya.
    • Journal Title

      J.Antibiot. 61(12)

      Pages: 752-755

    • NAID

      10024825100

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] Macrocyclic hexaoxazoles as sequence- and mode-selective G-quadruplex binders2008

    • Author(s)
      M. Tera, H. Ishizuka, M. Takagi, M. Suganuma, K. Shin-ya, K. Nagasawa
    • Journal Title

      Angew. Chem. Int. Ed 47

      Pages: 5557-5560

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells.2008

    • Author(s)
      R. Betous, N. Puget, J. Selves, D. S. Biard, K. Shin-ya, K. M. Vasquez, C. Cazaux, J. -S. Hoffmann, et al.
    • Journal Title

      Mol. Carcinog. 48

      Pages: 369-378

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] FANCJ helicase defective in Fanconia anemia and breast cancer unwinds G-quadruplex DNA to defend genomic stability2008

    • Author(s)
      Y. Wu, K. Shin-ya, R. M. Brosh, Jr.
    • Journal Title

      Mol. Cell Biol. 28

      Pages: 4116-4128

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] Efrapeptin J, a new down-regulator of the molecular chaperone GRP78 from a marine Tolypocladium sp.2008

    • Author(s)
      Y. Hayakawa, Y. Hattori, T. Kawasaki, K. Kanoh, K. Adachi, Y. Shizuri, K. Shin-ya
    • Journal Title

      J. Antibiot. 28

      Pages: 365-371

    • NAID

      10021927947

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] A novel versipelostatin analogue, versipelostatin F isolated from Streptomyces versipellis 4083-SVS62008

    • Author(s)
      J. Ueda, S. Chijiwa, M. Takagi, K. Shin-ya
    • Journal Title

      J. Antibiot 61

      Pages: 725-755

    • NAID

      10024825100

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] Efrapeptin J, a new down-regulator of the molecular chaperone GRP78 from a marine Tolypocladium sp2008

    • Author(s)
      Hayakawa, Y., Hattori, Y., Kawasaki, T., Kanoh, K., Adachi, K., Shizuri, Y., Shin-ya, K.
    • Journal Title

      J. Antibiot. 61

      Pages: 365-371

    • NAID

      10021927947

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390031
  • [Journal Article] JBIR-26, a novel natural compound from Streptomyces sp. AK-AH76, regulates mammalian circadian clock.2008

    • Author(s)
      Miho Izumikawa, Hideki Ukai, Motoki Takagi, Hiroki R. Ueda, Kazuo Shin-ya.
    • Journal Title

      J.Antibiot. 61(12)

      Pages: 756-758

    • NAID

      10024825110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] Macrocyclic hexaoxazoles as sequence-and mode-selective G-quadruplex binders.2008

    • Author(s)
      Masayuki. Tera, Hiromichi Ishizuka, Motoki Takagi, Masami Suganuma, Kazuo Shin-ya, Kazuo Nagasawa.
    • Journal Title

      Angew.Chem.Int.Ed. 47(30)

      Pages: 5557-5560

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] Studying telomere replication by Q-CO-FISH : the effect of telomestatin, a potent G-quadruplex ligand2008

    • Author(s)
      N. Arnoult, K. Shin-ya, J. -A. Londono-Vallejo
    • Journal Title

      Cytogenet. Genome Res. 122

      Pages: 229-236

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin2008

    • Author(s)
      J. Matsuo, Y. Tsukumo, J. Sakurai, S. Tsukahara, H. -R. Park, K. Shin-ya, T. Watanabe, T. Tsuruo, A. Tomida
    • Journal Title

      Cancer Sci. 100

      Pages: 327-333

    • NAID

      10025142654

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] JBIR-26, a novel natural compound from Streptomyces sp. AK-AH76, regulates mammalian circadian clock2008

    • Author(s)
      M. Izumikawa, H. Ukai, M. Takagi, H. Ueda, K. Shin-ya
    • Journal Title

      J. Antibiot 61

      Pages: 326-329

    • NAID

      10024825110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Journal Article] Relative and absolute configuration of versipelostatin, a down-regulator of molecular chaperone GRP78 expression2007

    • Author(s)
      Park, H.-R., Chijiwa, S., Furihata, K., Hayakawa, Y., Shin-ya, K.
    • Journal Title

      Org. Lett. 9

      Pages: 1457-1460

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390031
  • [Journal Article] Burkholone, a new cytotoxic antibiotic against IGF-I dependent cells from Burkholderia sp2007

    • Author(s)
      Mori, T., Yamashita, T., Furihata, K., Nagai, K., Suzuki, K., Hayakawa, Y., Shin-ya, K.
    • Journal Title

      J. Antibiot. 60

      Pages: 713-716

    • NAID

      10019972488

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390031
  • [Journal Article] Structure of thioviridamide, a novel apoptosis inducer from Streptomyces olivoviridis2006

    • Author(s)
      Hayakawa, Y., Sasaki, K., Nagai, K., Shin-ya, K., Furihata, K.
    • Journal Title

      J. Antibiot. 59

      Pages: 6-10

    • NAID

      10017147062

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390031
  • [Journal Article] Thioviridamide, a novel apoptosis inducer in transformed cells from Streptomyces olivoviridis2006

    • Author(s)
      Hayakawa, Y., Sasaki, K., Adachi, H., Furihata, K., Nagai, K., Shin-ya, K.
    • Journal Title

      J. Antibiot. 59

      Pages: 1-5

    • NAID

      10017147044

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390031
  • [Journal Article] Mevashuntin, a novel metabolite produced by inhibition of the mevalonate pathway in Streptomyces prunicolor2005

    • Author(s)
      Shin-ya, K., Umeda, Y., Chijiwa, S., Furihata, K., Furihata, K., Hayakawa, Y., Seto, H.
    • Journal Title

      Tetrahedron Lett. 46

      Pages: 1273-1276

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390031
  • [Journal Article] Novel antitumor and neuroprotective substances discovered by characteristic screenings based on specific molecular targets.2005

    • Author(s)
      Kazuo Shin-ya
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry 69・5

      Pages: 867-872

    • NAID

      130000030314

    • Data Source
      KAKENHI-PROJECT-17390031
  • [Presentation] I型ポリケタイド合成酵素の精密改変による 次世代天然物化学2023

    • Author(s)
      工藤慧、新家一男
    • Organizer
      第75回 日本生物工学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-23H05474
  • [Presentation] BIOSYNTHESIS APPLICATION OF MODULE EDITING TECHNIQUE ON MODULAR PKS FOR THE PRODUCTION OF BIOACTIVE DERIVATIVES2023

    • Author(s)
      新家一男
    • Organizer
      Japan-German Joint Symposium on Natural Product Biosynthesis Kyoto, 2023
    • Invited
    • Data Source
      KAKENHI-PROJECT-23H05474
  • [Presentation] Application of the heterologous expression technology for the derivatization of type-I PKS and NRPS compound2023

    • Author(s)
      新家一男
    • Organizer
      2023 KMB Annual Meeting & International Symposium
    • Invited
    • Data Source
      KAKENHI-PROJECT-23H05474
  • [Presentation] Application of the heterologous expression technology for the derivatization of type-I PKS2023

    • Author(s)
      新家一男
    • Organizer
      KAIST Special Symposium on Engineering Biology Distinguished Profs Seminar
    • Invited
    • Data Source
      KAKENHI-PROJECT-23H05474
  • [Presentation] 微生物二次代謝産物生合成遺伝子を応用した工業基幹物質生産2023

    • Author(s)
      新家一男
    • Organizer
      天然物創薬研究会 Study Group on Natural Products (SNAP) Drug Discovery 2023
    • Invited
    • Data Source
      KAKENHI-PROJECT-23H05474
  • [Presentation] 海洋性難培養微生物が生産する有用物質の異種生産技術に関する研究2020

    • Author(s)
      工藤 慧、西田 みち代、酒井 紀子、末永 光、池田 治生、新家 一男
    • Organizer
      日本農芸化学会2020年度大会
    • Data Source
      KAKENHI-PROJECT-19KK0146
  • [Presentation] E1A発現細胞選択的細胞死を誘導するJBIR-140の作用機構解析2019

    • Author(s)
      高瀬 翔平、堂前 直、新家 一男、長田 裕之、伊藤 昭博、吉田 稔
    • Organizer
      第23回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-26221204
  • [Presentation] JBIR-140の細胞増殖抑制機構の解析 / Analysis of the mode of action of an apoptosis inducer JBIR-1402018

    • Author(s)
      松本 健、高瀬翔平、近藤恭光、鈴木健裕、堂前 直、新家一男、長田裕之、久城哲夫、吉田 稔
    • Organizer
      日本ケミカルバイオロジー学会第13回年会
    • Data Source
      KAKENHI-PROJECT-26221204
  • [Presentation] HP1αクロモドメインを用いたヒストンH3修飾の蛍光プローブの開発とクロマチン動態観察2018

    • Author(s)
      佐々木和樹、鈴木律裕、新家一男、中尾洋一、吉田稔
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-26221204
  • [Presentation] Application of advanced technology of natural product chemistry for drug discovery2017

    • Author(s)
      Kazuo Shin-ya
    • Organizer
      APAC DAEWG Events at Bio Japan 2017
    • Invited
    • Data Source
      KAKENHI-PROJECT-26221204
  • [Presentation] Cloning and heterologous expression of bacterial secondary metabolites produced in actinomycetes and Pseudomonas hosts2017

    • Author(s)
      Kazuo Shin-ya
    • Organizer
      China/Japan Symposium on Natural Product Biosynthesis
    • Invited
    • Data Source
      KAKENHI-PROJECT-26221204
  • [Presentation] Heterologous expression of large biosynthetic gene clusters originated from actinomycetes and Pseudomonas2017

    • Author(s)
      Kazuo Shin-ya
    • Organizer
      U.S./Japan Seminar on Natural Product Biosynthesis Enzymology, Structural Biology, Drug Discovery, and Genome Mining
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26221204
  • [Presentation] Continued Efforts to Discover New Drugs using Natural Resources2017

    • Author(s)
      Kazuo Shin-ya
    • Organizer
      日本製薬工業協会、第6回アジア製薬団体連携会議; Asia Partnership Conference of Pharmaceutical Associations (APAC), 創薬連携 (Drug Discovery Alliances;DA)
    • Invited
    • Data Source
      KAKENHI-PROJECT-26221204
  • [Presentation] 巨大生合成遺伝子クラスターを応用した異種発現システムの開発2017

    • Author(s)
      新家 一男
    • Organizer
      「生合成リデザイン」第3回公開シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-26221204
  • [Presentation] 世界最大の天然物ライブラリーを用いたハイスループットランダムスクリーニング2013

    • Author(s)
      新家 一男
    • Organizer
      第31回 日本ヒト細胞学会学術集会
    • Place of Presentation
      埼玉県、所沢
    • Invited
    • Data Source
      KAKENHI-PROJECT-23380067
  • [Presentation] 世界最大級の天然物 ライブラリーの大規模HTSへの応用2013

    • Author(s)
      新家 一男
    • Organizer
      第333回CBI学会研究講演会 (招待講演)
    • Place of Presentation
      東京都、東京大学
    • Invited
    • Data Source
      KAKENHI-PROJECT-23380067
  • [Presentation] 世界最大級の天然物 ライブラリーの大規模HTS への応用2013

    • Author(s)
      新家 一男
    • Organizer
      第333回CBI 学会研究講演会
    • Place of Presentation
      東京, 東京大学山上会館
    • Year and Date
      2013-01-22
    • Data Source
      KAKENHI-PROJECT-23380067
  • [Presentation] 世界最大の天然物ライブラリーを用いたハイスループットランダムスクリーニング2013

    • Author(s)
      新家 一男
    • Organizer
      第31回日本ヒト細胞学会学術集会
    • Place of Presentation
      埼玉県, 所沢市民文化センター
    • Year and Date
      2013-08-10
    • Data Source
      KAKENHI-PROJECT-23380067
  • [Presentation] 天然物のハイスループットランダムスクリーニングへの応用2012

    • Author(s)
      新家一男
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      神奈川県、慶應義塾大学(招待講演)
    • Year and Date
      2012-03-25
    • Data Source
      KAKENHI-PROJECT-23380067
  • [Presentation] 天然物のハイスル-プットランダムスクリーニングへの応用2012

    • Author(s)
      新家 一男
    • Organizer
      日本化学会 第92 春季年会
    • Place of Presentation
      神奈川県, 慶應義塾大学キャンパス
    • Year and Date
      2012-03-20
    • Data Source
      KAKENHI-PROJECT-23380067
  • [Presentation] 海綿由来の放線菌より単離した新規anthracycline2010

    • Author(s)
      本橋慶一郎、高木基樹、新家一男
    • Organizer
      2010年日本農芸化学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Presentation] JBIR-23, a novel compound of microbial origin, induces cytotoxicity against malignant mesothelioma cells by tubulin polymerization and apoptosis2010

    • Author(s)
      高木基樹、村上秀樹、Hwang Ji-Hwan、関戸好孝、新家一男
    • Organizer
      AACR Cell Death Mechanisms and Cancer Therapy
    • Place of Presentation
      San Diego
    • Year and Date
      2010-02-03
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Presentation] 新規GRP78発現抑制物質JBIR-52に関する研究2010

    • Author(s)
      小曽根郁子、上田純也、高木基樹、新家一男
    • Organizer
      2010年日本農芸化学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Presentation] JBIR-23, a novel compound of microbial origin, induces cytotoxicity against malignant mesothelioma cells by tubulin polymerization and apoptosis2010

    • Author(s)
      新家一男、村上秀樹、Hwang Ji-Hwan、関戸好孝、高木基樹
    • Organizer
      8th AACR-JCA Joint meeting
    • Place of Presentation
      Waikoloa, Hawaii
    • Year and Date
      2010-02-09
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Presentation] プロテアソーム形成を阻害する化合物JBIR-22に関する研究2010

    • Author(s)
      泉川美穂、橋本絢子、広川貴次、杉本聡、加藤平、高木基樹、新家一男
    • Organizer
      2010年日本農芸化学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Presentation] 新種のStreptomyces属から単離された新規化合物に関する研究2009

    • Author(s)
      本橋慶一郎、Tabrez Shams Khan、小牧久幸、小曽根育子、向井啓、高木基樹、新家一男
    • Organizer
      天然有機化合物討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-10-08
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Presentation] 新規化合物JBIR-23の中皮腫細胞に対する殺細胞活性発現メカニズムに関する報告2009

    • Author(s)
      J. -H. Hwang, 本橋慶一郎, 関戸好孝, 高木基樹, 新家一男
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Presentation] 新規抗酸化化合物JBIR-12に関する研究2009

    • Author(s)
      泉川美穂, 永井文, 土井隆行, 高木基樹, 新家一男
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Presentation] 新規化合物JBIR-23の中皮腫細胞に対する殺細胞活性発現メカニズムに関する報告2009

    • Author(s)
      Hwang Ji-Hwan、本橋慶一郎、関戸好孝、高木基樹、新家一男
    • Organizer
      2009年日本農芸化学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Presentation] 中皮腫細胞に対して抗がん活性を示す化合物のスクリーニング2009

    • Author(s)
      本橋慶一郎、Hwang Ji-Hwan、関戸好孝、高木基樹、新家一男
    • Organizer
      2009年日本農芸化学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Presentation] 中皮腫細胞に対して抗癌活性を示す化合物のスクリーニング2009

    • Author(s)
      本橋慶一郎, J. -H. Hwang, 関戸好孝, 高木基樹, 新家一男
    • Organizer
      日本農芸化学会2009年度大会
    • Place of Presentation
      福岡
    • Year and Date
      2009-03-28
    • Data Source
      KAKENHI-PROJECT-20380070
  • [Presentation] アデノウィルス癌遺伝子導入細胞に対して選択的アポトーシスを誘導するthioviridamideの研究2006

    • Author(s)
      早川洋一、佐々木佳穂里、足立久、新家一男、降旗一夫、永井浩二
    • Organizer
      日本農芸化学会
    • Data Source
      KAKENHI-PROJECT-17390031
  • [Presentation] 放線菌二次代謝産物異種発現生産の大規模検証

    • Author(s)
      新家 一男
    • Organizer
      生物工学会第66回大会 シンポジウム「天然物生合成研究の最前線」
    • Place of Presentation
      北海道札幌市白石区(札幌コンベンションセンター)
    • Year and Date
      2014-09-09 – 2014-09-11
    • Invited
    • Data Source
      KAKENHI-PROJECT-26221204
  • [Presentation] 世界最大級の天然物ライブラリーを用いたハイスループットランダムスクリーニング

    • Author(s)
      新家 一男
    • Organizer
      第20回天然薬物の開発と応用シンポジウム薬学セミナー
    • Place of Presentation
      東京都文京区(東京大学 弥生講堂一条ホール)
    • Year and Date
      2014-11-05 – 2014-11-06
    • Invited
    • Data Source
      KAKENHI-PROJECT-26221204
  • 1.  HAYAKAWA Yoichi (20208606)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 8 results
  • 2.  SETO Haruo (10013335)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  FURIHATA Kazuo (20219091)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  末永 光 (90357252)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 5.  KAWASAKI Takashi (00408733)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  KUZUYAMA Tomohisa (30280952)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  工藤 慧 (80828161)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 8.  FURIHATA Keiko
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  Yoshida Minoru (80191617)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 10.  渡邉 秀典 (00202416)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  石神 健 (70292787)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  中尾 洋一 (60282696)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  今井 賢一郎 (80442573)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  FUJITA Ken-ich
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  HIGUCHI Keiichiro
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  降旗 圭子
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  KOMATSU Mamoru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 18.  上岡 麗子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  近藤 恭光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  近藤 豊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  平尾 敦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  大田 久美子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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