TOMINAGA Kaoru 冨永薫

… Alternative Names

Tominaga Kaoru 冨永薫

TOMINAGA KAORU 冨永薫

冨永薫トミナガカオル

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Researcher Number	20265242
Other IDs
Affiliation (Current)	2025: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2025: 自治医科大学, 医学部, 教授 2020 – 2023: 自治医科大学, 医学部, 教授 2017 – 2019: 自治医科大学, 医学部, 准教授 2012 – 2015: 自治医科大学, 医学部, 准教授 1995 – 1996: 自治医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 48010:Anatomy-related / Bacteriology (including Mycology) / General anatomy (including histology/embryology) / epigenetics Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Bacteriology (including Mycology)
Keywords	Principal Investigator ヒストンアセチル化 / 神経幹細胞 / クロマチン / 転写制御 / 神経発生 / マウスモデル / エピジェネティクス / リポ多糖 / 神経分化 / モデルマウス … More / 遺伝子発現 / 細胞増殖 / NF-κB / MAPキナーゼ / マクロファージ / HeJマウス / C3H / 線維芽細胞 / IL-6 … More Except Principal Investigator BCL-2 / ミトコンドリア / カルニチン / CPT1 / ベネトクラクス / 白血病 / 脂肪酸 / nitric oxide production / lipopolysaccharide / BCG-infection / scavenger-gene knockout mice / scavenger receptor / LPS(リポ多糖) / 感染防御 / ノックアウトマウス / スカベンジャー受容体 Less

神経幹細胞の運命と機能的な脳構築を牽引するミトコンドリア機能の解明Principal Investigator
- Principal Investigator
  
  冨永薫
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Jichi Medical University
Targeting mitochondrial fatty acid transportation as novel therapy for Bcl-2 inhibitor resistant leukemia
- Principal Investigator
  
  佐藤一也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Jichi Medical University
Investigation of chromatin regulation network for fate decision of neural stem cells and establishment of functional brain structurePrincipal Investigator
- Principal Investigator
  
  冨永薫
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48010:Anatomy-related
- Research Institution
  Jichi Medical University
The role of epigenetic regulator in neural stem cell maintenance and differentiationPrincipal Investigator
- Principal Investigator
  
  Tominaga Kaoru
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General anatomy (including histology/embryology)
- Research Institution
  Jichi Medical University
Mechanism of neural stem cell maintenance by chromatin regulatorPrincipal Investigator
- Principal Investigator
  
  TOMINAGA KAORU
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  epigenetics
- Research Institution
  Jichi Medical University
リポ多糖(LPS)によるマウスマクロファージ及び線維芽細胞の活性比に関する研究Principal Investigator
- Principal Investigator
  
  冨永薫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Jichi Medical University
THE ROLE OF SCAVENGER RECEPTORS ON MURINE MACROPHAGES AGAINST INFECTION
- Principal Investigator
  
  NAKANO Masyasu
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  JICHI MEDICAL SCHOOL
リポ多糖(LPS)低応答性C3H/HeJマウス由来細胞株の樹立Principal Investigator
- Principal Investigator
  
  富永薫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Jichi Medical University

All 2024 2023 2022 2021 2019 2017 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Fatty Acids Play a Critical Role in Mitochondrial Oxidative Phosphorylation in Effector T Cells in Graft-versus-Host Disease2024
- Author(s)
  Nakano Hirofumi、Sato Kazuya、Izawa Junko、Takayama Norihito、Hayakawa Hiroko、Ikeda Takashi、Kawaguchi Shin-Ichiro、Mashima Kiyomi、Umino Kento、Morita Kaoru、Ito Ryoji、Ohno Nobuhiko、Tominaga Kaoru、Endo Hitoshi、Kanda Yoshinobu
- Journal Title
  
  ImmunoHorizons
  
  Volume: 8 Issue: 3 Pages: 228-241
- DOI
  10.4049/immunohorizons.2300115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07576, KAKENHI-PROJECT-21K06760, KAKENHI-PROJECT-22K16309
[Journal Article] Tip60/KAT5 Histone Acetyltransferase Is Required for Maintenance and Neurogenesis of Embryonic Neural Stem Cells2023
- Author(s)
  Tominaga Kaoru、Sakashita Eiji、Kasashima Katsumi、Kuroiwa Kenji、Nagao Yasumitsu、Iwamori Naoki、Endo Hitoshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 3 Pages: 2113-2113
- DOI
  10.3390/ijms24032113
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06760, KAKENHI-PROJECT-19H03139, KAKENHI-PROJECT-20K07576
[Journal Article] Dimethyl fumarate ameliorates graft‐versus‐host disease by inhibiting T‐cell metabolism and immune responses through a reactive oxygen species‐dependent mechanism2022
- Author(s)
  Mashima Kiyomi、Sato Kazuya、Ikeda Takashi、Izawa Junko、Takayama Norihito、Hayakawa Hiroko、Kawaguchi Shin‐Ichiro、Nakano Hirofumi、Nagayama Takashi、Umino Kento、Morita Kaoru、Tominaga Kaoru、Endo Hitoshi、Kanda Yoshinobu
- Journal Title
  
  British Journal of Haematology
  
  Volume: 00 Issue: 6 Pages: 1-5
- DOI
  10.1111/bjh.18082
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17841, KAKENHI-PROJECT-20K07576, KAKENHI-PROJECT-21K06760, KAKENHI-PROJECT-22K08463
[Journal Article] Mesenchymal stromal cells inhibit aerobic glycolysis in activated T-cells by negatively regulating hexokinase II activity through PD-1/PD-L1 interaction.2021
- Author(s)
  Kawasaki, Y., Sato, K., Mashima, K., Nakano, H., Ikeda, T., Umino, K., Morita, K., Izawa, J., Takayama, N., Hayakawa, H., Tominaga, K., Endo, H., Kanda, Y.
- Journal Title
  
  Biology of Blood and Marrow Transplantation
  
  Volume: 27 Issue: 3 Pages: 231.e1-231.e8
- DOI
  10.1016/j.jtct.2020.11.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07576, KAKENHI-PROJECT-17K08497, KAKENHI-PROJECT-17K11248, KAKENHI-PROJECT-19K17841
[Journal Article] Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers the activation of the integral stress response in vivo2021
- Author(s)
  Kuroda Rintaro、Tominaga Kaoru、Kasashima Katsumi、Kuroiwa Kenji、Sakashita Eiji、Hayakawa Hiroko、Kouki Tom、Ohno Nobuhiko、Kawai Kensuke、Endo Hitoshi
- Journal Title
  
  PLOS ONE
  
  Volume: 16 Issue: 7 Pages: 1-21
- DOI
  10.1371/journal.pone.0255355
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07576, KAKENHI-PROJECT-21K06760
[Journal Article] Comprehensive Metabolomic Analysis of IDH1(R132H) Clinical Glioma Samples Reveals Suppression of β-oxidation Due to Carnitine Deficiency.2019
- Author(s)
  Miyata S, Tominaga K*, Sakashita E, Urabe M, Onuki Y, Gomi A, Yamaguchi T, Mieno M, Mizukami H, Kume A, Ozawa K, Watanabe E, Kawai K, Endo H.
- Journal Title
  
  Sci Rep.
  
  Volume: 9 Issue: 1 Pages: 9787-9787
- DOI
  10.1038/s41598-019-46217-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08497, KAKENHI-PROJECT-17K11248
[Journal Article] The emerging role of senescent cells in tissue homeostasis and pathophysiology2015
- Author(s)
  Tominaga, K.
- Journal Title
  
  Pathobiol Aging Age Relat Dis
  
  Volume: 5 Issue: 1 Pages: 27743-27743
- DOI
  10.3402/pba.v5.27743
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24613006
[Journal Article] The emerging role of senescent cells in tissue homeostasis and pathophysiology.2015
- Author(s)
  Tominaga, K.
- Journal Title
  
  Pathobiol Aging Age Relat Dis.
  
  Volume: 5
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24613006
[Journal Article] Rapid selection of XO embryonic stem cells using Y chromosome-linked GFP transgenic mice.2014
- Author(s)
  Yamamoto, S., Nagao, Y., Kuroiwa, K., Hakamata, Y., Ichida, M., Saito-Ohara, F., Tominaga, K., and Endo, H.
- Journal Title
  
  Transgenic Res.
  
  Volume: 23 Issue: 5 Pages: 757-765
- DOI
  10.1007/s11248-014-9813-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24613006
[Journal Article] Paraneoplastic cerebellar degeneration associated with an onconeural antibody against creatine kinase, brain-type2013
- Author(s)
  Tetsuka, S. Tominaga, K. Ohta, E. Kuroiwa, K. Sakashita, E. Kasashima, K. Hamamoto, T. Namekawa, M. Morita, M. Natsui, S. Morita, T. Tanaka, K. Takiyama, Y. Nakano, I. Endo, H.
- Journal Title
  
  J Neurol Sci
  
  Volume: 335 Issue: 1-2 Pages: 48-57
- DOI
  10.1016/j.jns.2013.08.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249048, KAKENHI-PROJECT-23500455, KAKENHI-PROJECT-24613006, KAKENHI-PROJECT-24790324
[Journal Article] The role of chromatin reorganization in the process of cellular senescence2012
- Author(s)
  冨永　薫
- Journal Title
  
  Curr Drug Targets
  
  Volume: 13 Pages: 1593-1602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24613006
[Presentation] 変異型イソクエン酸脱水素酵素1 (IDH1)を有するグリオーマ臨床検体における低カルニチンと脂肪酸酸化の抑制2019
- Author(s)
  冨永　薫、宮田　五月、坂下　英司、澤口　武尊、黒田　林太郎、川合　謙介、遠藤　仁司
- Organizer
  がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-17K08497
[Presentation] 変異型イソクエン酸脱水素酵素1 (IDH1) を持つグリオーマは、低カルニチンによりβ酸化が抑制されている2017
- Author(s)
  冨永　薫、宮田　五月、坂下　英司、澤口　武尊、黒田　林太郎、川合　謙介、遠藤　仁司
- Organizer
  生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K08497
[Presentation] 発達段階特異的RNA結合蛋白質Drb1の細胞質封入体形成機構の解析2015
- Author(s)
  益子貴史、坂下英司、笠嶋克巳、黒岩憲二、冨永薫、松浦徹、遠藤仁司
- Organizer
  日本分子生物学会、日本生化学会
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-24613006
[Presentation] Rapid selection of XO embryonic stem cells using Y chromosome-linked GFP transgenic mice2015
- Author(s)
  遠藤仁司、山本智、長尾泰光、黒岩憲二、市田勝、冨永薫
- Organizer
  日本分子生物学会、日本生化学会
- Place of Presentation
  神戸ポートアイランド（神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-24613006
[Presentation] ヒストン修飾によるスプライシング制御が精子形成過程を制御する2015
- Author(s)
  岩森巨樹、冨永薫、岩森督子、佐藤哲也、大川恭行、小野悦路、Martin Matzuk
- Organizer
  日本エピジェネティクス研究会
- Place of Presentation
  学術総合センター　一橋講堂（東京都千代田区）
- Year and Date
  2015-05-25
- Data Source
  KAKENHI-PROJECT-24613006
[Presentation] Chromatin regulator MRG15 is required for spermatogenesis in mice
- Author(s)
  Kaoru Tominaga
- Organizer
  The 10th Nikko International Symposium 2013
- Place of Presentation
  Jichi Medical University, Tochigi, JAPAN
- Invited
- Data Source
  KAKENHI-PROJECT-24613006

1. NAKANO Masyasu (70048958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. KIRIKAE Teruo (50192563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KII Michisato (00012766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 佐藤一也 (60382917)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 神田善伸 (30334379)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 遠藤仁司 (50221817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
7. TANAKA Keiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 森田薫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TOMINAGA Kaoru 冨永 薫

Tominaga Kaoru 冨永 薫

TOMINAGA KAORU 冨永 薫

冨永 薫 トミナガ カオル

Research Projects

Research Products

Co-Researchers

神経幹細胞の運命と機能的な脳構築を牽引するミトコンドリア機能の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting mitochondrial fatty acid transportation as novel therapy for Bcl-2 inhibitor resistant leukemia

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of chromatin regulation network for fate decision of neural stem cells and establishment of functional brain structurePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of epigenetic regulator in neural stem cell maintenance and differentiationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of neural stem cell maintenance by chromatin regulatorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

リポ多糖(LPS)によるマウスマクロファージ及び線維芽細胞の活性比に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

THE ROLE OF SCAVENGER RECEPTORS ON MURINE MACROPHAGES AGAINST INFECTION

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

リポ多糖(LPS)低応答性C3H/HeJマウス由来細胞株の樹立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Fatty Acids Play a Critical Role in Mitochondrial Oxidative Phosphorylation in Effector T Cells in Graft-versus-Host Disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tip60/KAT5 Histone Acetyltransferase Is Required for Maintenance and Neurogenesis of Embryonic Neural Stem Cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dimethyl fumarate ameliorates graft‐versus‐host disease by inhibiting T‐cell metabolism and immune responses through a reactive oxygen species‐dependent mechanism2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mesenchymal stromal cells inhibit aerobic glycolysis in activated T-cells by negatively regulating hexokinase II activity through PD-1/PD-L1 interaction.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Loss of mitochondrial transcription factor A in neural stem cells leads to immature brain development and triggers the activation of the integral stress response in vivo2021

Author(s)

Journal Title

DOI

Data Source

TOMINAGA Kaoru 冨永薫

Tominaga Kaoru 冨永薫

TOMINAGA KAORU 冨永薫

冨永薫トミナガカオル