Sakamaki Kazuhiro 酒巻和弘

… Alternative Names

SAKAMAKI Kazuhiro 酒巻和弘

酒巻和宏サカマキカズヒロ

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Researcher Number	20271017
Other IDs
Affiliation (Current)	2025: 京都大学, 生命科学研究科, 准教授 2025: 京都大学, 医学研究科, 研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 京都大学, 生命科学研究科, 准教授 2012: 京都大学, 大学院・生命科学研究科, 准教授 2008 – 2011: Kyoto University, 生命科学研究科, 准教授 2001 – 2006: 京都大学, 生命科学研究科, 助教授 2003: 京都大学, 大学院・生命科学研究科, 助教授 … More 1998 – 2001: 京都大学, ウイルス研究所, 助教授 1998 – 1999: 京都大学, ウィルス研究所, 助教授 1995 – 1997: 京都大学, ウイルス研究所, 助手 1988: Researcher, Department of Molecular Biology, Osaka Bioscience Institute, 第1研究部, 特別研究員 Less
Review Section/Research Field	Principal Investigator Biological Sciences / Developmental biology / Basic Section 38030:Applied biochemistry-related / Functional biochemistry Except Principal Investigator Biological Sciences / Pathological medical chemistry / Laboratory animal science / Cell biology / Immunology / System genome science
Keywords	Principal Investigator 細胞死 / アポトーシス / カスパーゼ / デスレセプター / Cre / Caspase-8 / MC159 / FADD / トランスジェニックカエル / 偽プロテアーゼ … More / 分子進化 / フェロプトーシス / 鉄硫黄タンパク質 / Fenton反応 / 二価鉄イオン / c-FLIP / 鉄結合タンパク質 / 擬プロテアーゼ / loxP / fluorescent protein / Xenopus / Transgenic / 3次元画像 / DsRed / GFP / Death Effector Domain / apoptosis / デス-エフェクター・ドメイン / デス・エフェクター・ドメイン / caspase-8 / デス-エフェクター-ドメイン / イメージング / 可視化 / モニター分子 / アフリカツメガエル / 胚発生 / 発生遺伝 / プロテアーゼ / タンパク質構造 / 分子系統 / ノックアウトマウス / キメラマウス / ミトコンドリア / Fas … More Except Principal Investigator アポトーシス / Fas / Tax / カスパーゼ / FLASH / caspase / Ras / 細胞死 / recombination / LoxP / Cre / TAT / HIV / 自己免疫疾患 / マップキナーゼ / gldマウス / 卵巣 / Fas抗原(Fas) / MST / Neutrophil / Proliferaton and differentiaton / Myeloid leukemia / Granulocyte colony-stimulating factor / Haemopoiesis / 細胞の増殖と分化 / 遺伝子工学 / 多能性幹細胞 / 好酸球 / ミエルペルオキシダーゼ / 受容体 / 血球の増殖と分化 / 増殖・分化因子 / 骨髄性白血病細胞 / 好酸球ペルオキシダーゼ / ミエロペルオキシダーゼ / 顆粒球コロニー刺激因子 / マウス / トランスジェニック / コンデショナル / 遺伝子組み換え / MAP kinase / apoptosis / cell death / アデノウイルスE1B / glomerulonephritis / Rheumatold arthritis / Autoimmune disease / gld mouse / Transgenic mouse / Apoptosis / Fas Antigen (Fas) / 劇症肝炎 / lprマウス / 胸腺 / 糸球体腎炎 / リウマチ様関節炎 / トランスジェニックマウス / 細胞内シグナル / プロテインカイネース / 蛋白ライブラリー / プロテアーゼ / 蛋白質代謝 / カスパーゼ3 / 無細胞蛋白質合成系 / Alpha Screen / AlphaScreen / コムギ胚芽 / プロテインアレイ / 切断 / タンパク質 / プロテオリシス / 無細胞タンパク質合成 / 蛋白質ネットワーク / シグナル伝達 / 細胞・組織 / 癌 / 遺伝子 / 異種移植 / 細胞内シグナル伝達阻害因子 / 細胞死受容体 / 選択的死滅 / 卵胞 / 哺乳類 / TRAF / リンパ球 / FADD / caspsae-8 / TIFA / NFκB / CD40 / TRAF6 / CSCL16 / SR-PSOX / カスパーゼ8 / RAS / マデノウイルスE1B / lymphopadenopathy / HTLV-1(成人T細胞白血病ウイルス) / ras / プロテインキナーゼ Less

Structural analysis of cFLIP as an iron-binding protein and elucidation of a new physiological functionPrincipal Investigator
- Principal Investigator
  
  Sakamaki Kazuhiro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Kyoto University
Comprehensive identification of caspase-dependent signal transduction pathway using cell-free protein array
- Principal Investigator
  
  SAWASAKI Tatsuya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  System genome science
- Research Institution
  Ehime University
In vivo imaging of embryonic cell death in the new model animal and its molecular analysisPrincipal Investigator
- Principal Investigator
  
  SAKAMAKI Kazuhiro
- Project Period (FY)
  2009 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Kyoto University
比較ゲノム情報に基づくアポトーシス実行因子の普遍性と多様性の解析Principal Investigator
- Principal Investigator
  
  酒巻和弘
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Study for the cell lineage and tissue specificity in embryonic cells using transgenic Xenopus frogsPrincipal Investigator
- Principal Investigator
  
  SAKAMAKI Kazuhiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Developmental biology
- Research Institution
  Kyoto University
Fasを介するアポトーシスシグナル抑制による細胞がん化分子機構の解析
- Principal Investigator
  
  米原伸
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Studies on In Vivo gene modification by injection of TAT-Cre fusion protein and establishment of the practical technique.
- Principal Investigator
  
  YAMADA Shuichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Kyoto University
遺伝子欠損マウスを用いたアポトーシス抑制に伴う発癌機構の解明Principal Investigator
- Principal Investigator
  
  酒巻和弘
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
アポトーシス実行因子カスパーゼ8のがん抑制因子としての機能解析Principal Investigator
- Principal Investigator
  
  酒巻和弘
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
哺乳類卵胞の選択的死滅制御機構とその人為支配による潜在的卵巣卵の利用
- Principal Investigator
  
  眞鍋昇
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  The University of Tokyo
  Kyoto University
アポトーシスの情報伝達制御
- Principal Investigator
  
  米原伸
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
デスレセプターを介したアポトーシス誘導に関与するカスパーゼの機能解析Principal Investigator
- Principal Investigator
  
  酒巻和弘
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Analysis of intracellular regulatory signaling for apoptosis induction
- Principal Investigator
  
  YONEHARA Shin
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Cell biology
- Research Institution
  KYOTO UNIVERSITY
Fasを介するアポトーシスの分子機構と生理機能の解析
- Principal Investigator
  
  米原伸
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
Analysis of the structure and interaction of apoptotic signaling molecules via FasPrincipal Investigator
- Principal Investigator
  
  SAKAMAKI Kazuhiro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  KYOTO UNIVERSITY
細胞および生体レベルにおけるFas抗原の作用機構
- Principal Investigator
  
  YONEHARA Shin
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
In vivo function of Fas antigen in the immune system
- Principal Investigator
  
  YONEHARA Shin
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  KYOTO UNIVERSITY
Proliferation and differentiation of granulocytes
- Principal Investigator
  
  NAGATA Shigekazu
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka Bioscience Institute

All 2022 2012 2011 2010 2009 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] The Ovary (2nd edition) Chapter 21 : Follicle selection in mammalian ovaries : Regulatory mechanisms of granulosa cell apoptosis during follicular atresia.(Leung PCR, Adashi E eds)(pp 369-385)2004
- Author(s)
  Noboru Manabe, Naoko Inoue, Takashi Miyano, Kazuhiro Sakamaki, Miki Sugimoto, Hajime Miyamoto
- Total Pages
  664
- Publisher
  Academic Press/Elsevier, New York, USA
- Data Source
  KAKENHI-PROJECT-13GS0008
[Journal Article] Multiple functions of FADD in apoptosis, NF- κB-related signaling, and heart development in Xenopus embryos2012
- Author(s)
  Kazuhiro Sakamaki、Chiyo Takagi、Atsushi Kitayama 、 Tomoko Kurata 、 Takamasa S. Yamamoto、 Kumiko Chiba、 Katsuya Kominami、Sang-Kee Jung、 Katsuya Okawa、 Masami Nozaki、Hiroshi Y. Kubota 、Naoto Ueno
- Journal Title
  
  Genes to Cells
  
  Volume: 17巻 Issue: 11 Pages: 875-896
- DOI
  10.1111/gtc.12004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570223
[Journal Article] The molecular mechanism of apoptosis upon caspase-8 activation: Quantitative experimental validation of a mathematical model2012
- Author(s)
  Kominami K, Nakabayashi J, Nagai T, Tsujimura Y, Chiba K, Kimura H, Miyawaki A, Sawasaki T, Yokota H, Manabe N, Sakamaki K
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1823 Pages: 1825-1840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310127
[Journal Article] Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling.2011
- Author(s)
  Akagi T, Shimizu K, Takahama S, Iwasaki T, Sakamaki K, Endo Y, Sawasaki T
- Journal Title
  
  FEBS Lett.
  
  Volume: 585 Pages: 1835-1840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22310127
[Journal Article] Caspases : evolutionary aspects of their functions in vertebrates2009
- Author(s)
  Kazuhiro Sakamaki, Yutaka Satou
- Journal Title
  
  Journal of Fish Biology 74
  
  Pages: 727-753
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20017016
[Journal Article] A transgenic Xenopus laevis strain expressing Crerecombinase in muscle cells.2006
- Author(s)
  Waldner, C., Sakamaki, K., Ueno, N., Turan, G., Ryffel, G.U.
- Journal Title
  
  Developmental Dynamics 235・8
  
  Pages: 2220-2228
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570176
[Journal Article] A transgenic Xenopus laevis strain expressing Cre recombinase in muscle cells2006
- Author(s)
  Waldner, C., Sakamaki, K., Ueno, N., Turan, G., Ryffel, G.U.
- Journal Title
  
  Developmental Dynamics 235
  
  Pages: 2220-2228
- Data Source
  KAKENHI-PROJECT-17570176
[Journal Article] Characteristics of initiation and early events for muscle development in the Xenopus limb bud.2005
- Author(s)
  Satoh, A., Sakamaki, K., Ide, H., Tamura, K.
- Journal Title
  
  Developmental Dynamics 234・4
  
  Pages: 846-857
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17570176
[Journal Article] The adaptor molecule FADD from Xenopus laevis demonstrates evolutionary conservation of its pro-apoptotic activity.2005
- Author(s)
  Kazuhiro Sakamaki, Chiyo Takagi, Katsuya Kominami, Shin-ichi Sakata, Yoshio Yaoita, Hiroshi Y. Kubota, Masami Nozaki, Shin Yonehara, Naoto Ueno
- Journal Title
  
  Genes to Cells 9・5
  
  Pages: 1249-1264
- Data Source
  KAKENHI-PROJECT-13GS0008
[Journal Article] Characteristics of initiation and early events for muscle development in the Xenopus limb bud.2005
- Author(s)
  Satoh A., Sakamaki K., Ide H., Tamura K.
- Journal Title
  
  Developmenta Dynamics 234
  
  Pages: 846-857
- Data Source
  KAKENHI-PROJECT-13GS0008
[Journal Article] Characteristics of initiation and early events for muscle development in the Xenopus limb bud.2005
- Author(s)
  Satoh, A., Sakamaki, K., Ide, H., Tamura, K.
- Journal Title
  
  Developmental Dynamics 234
  
  Pages: 846-857
- Data Source
  KAKENHI-PROJECT-17570176
[Journal Article] A caspase-8-independent signalling pathway activated by Fas ligation leads to exposure of Bax N-terminus.2005
- Author(s)
  Lilin Zhang, Shigeomi Shimizu, Kazuhiro, Sakamaki, Shin Yonehara, Yoshihide Tsujimoto
- Journal Title
  
  Journal of Biological Chemistry 279・10
  
  Pages: 33865-33874
- Data Source
  KAKENHI-PROJECT-13GS0008
[Journal Article] Xenografting of bovine secondary follicles into ovariectomized Regulation mechanism of selective atresia in porcine follicles : regulation of granulosa cell apoptosis during atresia.2004
- Author(s)
  Noboru Manabe, Yasufumi Goto, Fuko Matsuda-Minehata, Naoko Inoue, Akihisa Maeda, Miki Sugimoto, Kazuhiro Sakamaki, Takashi Miyano
- Journal Title
  
  Journal of Reproduction and Development 50・5
  
  Pages: 493-514
- Data Source
  KAKENHI-PROJECT-13GS0008
[Journal Article] Age-related thymic involution is mediated by Fas on thymic epithelial cells.2004
- Author(s)
  Nobuyuki Yajima, Kazuhiro Sakamaki, Shin Yonehara
- Journal Title
  
  International Immunology 16・5
  
  Pages: 1027-1035
- NAID
  10013292015
- Data Source
  KAKENHI-PROJECT-13GS0008
[Journal Article] Regulation of endothelial cell death and its role in angiogenesis and vascular regression.2004
- Author(s)
  Kazuhiro Sakamaki
- Journal Title
  
  Current Neurovascular Research 1・1
  
  Pages: 305-315
- Data Source
  KAKENHI-PROJECT-13GS0008
[Presentation] A functional analysis of a pseudoenzyme protein, cFLIP2022
- Author(s)
  Rhea Sarah DSouza, Yusuke Nakasone, Naoyuki Iwabe, Jin Sakamoto, Kentaro Tomii, Kazuhiro Sakamaki
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K05380
[Presentation] Analysis of programmed cell death in Xenoupus embryos using a FRET-based caspase biosensor2012
- Author(s)
  Kazuhiro Sakamaki、 Makoto Suzuki、 Chiyo Takagi 、Yusuke Hara 、Katsuya Kominami 、Kumiko Chiba、 Hiroshi Y. Kubota、 Naoto Ueno
- Organizer
  第45回日本発生生物学会
- Place of Presentation
  神戸
- Year and Date
  2012-05-31
- Data Source
  KAKENHI-PROJECT-21570223
[Presentation] 細胞死誘導アダプター分子 FADD の胚発生における機能解析2010
- Author(s)
  酒巻和弘、高木知世、木村春奈、鄭祥基、大川克也、上野直人
- Organizer
  第43回日本発生生物学会
- Place of Presentation
  京都
- Year and Date
  2010-06-21
- Data Source
  KAKENHI-PROJECT-21570223
[Presentation] 細胞死誘導アダプター分子FADDの胚発生における機能解析2010
- Author(s)
  酒巻和弘、高木知世、木村春奈、鄭祥基、大川克也、上野直人
- Organizer
  第43回日本発生生物学会
- Place of Presentation
  京都
- Year and Date
  2010-06-21
- Data Source
  KAKENHI-PROJECT-21570223
[Presentation] 細胞死に伴う小胞形成の時系列的変動の解析2010
- Author(s)
  酒巻和弘,坂本尚久,河村拓馬,千場久美子,澤崎達也,小山田耕二
- Organizer
  BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-22310127
[Presentation] カスパーゼ8及び類似分子の特異性に関する分子系統学的・タンパク質構造学的解析2009
- Author(s)
  酒巻和弘, 野崎正美, 芳本美智, 加藤博章, 後藤修
- Organizer
  日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20017016
[Presentation] Analysis of programmed cell death in Xenoupus embryos using a FRET-based caspase biosensor
- Author(s)
  Kazuhiro Sakamaki
- Organizer
  第45回日本発生生物学会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-21570223

1. YONEHARA Shin (00124503)

# of Collaborated Projects: 10 results

# of Collaborated Products: 0 results
2. LEE Kyung-won (50303912)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. UENO Naoto (40221105)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. SAWASAKI Tatsuya (50314969)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. YAMADA Shuichi (20261133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KONDO Sinae (40314182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. GOTO Kazuo (00205593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YOKOTA Hideo (00261206)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. NAGATA Shigekazu (70114428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. FUKUNAGA Rikiro (40189965)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KAZIRO Yoshito (90012690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 井上純一郎 (70176428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 眞鍋昇 (80243070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. 宮野隆 (80200195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 若山照彦 (40360672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 杉本実紀 (20243074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. 富井健太郎 (40357570)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
18. 中山瑞穂

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Sakamaki Kazuhiro 酒巻 和弘

SAKAMAKI Kazuhiro 酒巻 和弘

酒巻 和宏 サカマキ カズヒロ

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Research Products

Co-Researchers

Structural analysis of cFLIP as an iron-binding protein and elucidation of a new physiological functionPrincipal Investigator

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In vivo imaging of embryonic cell death in the new model animal and its molecular analysisPrincipal Investigator

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比較ゲノム情報に基づくアポトーシス実行因子の普遍性と多様性の解析Principal Investigator

Principal Investigator

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Review Section

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Study for the cell lineage and tissue specificity in embryonic cells using transgenic Xenopus frogsPrincipal Investigator

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Principal Investigator

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遺伝子欠損マウスを用いたアポトーシス抑制に伴う発癌機構の解明Principal Investigator

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アポトーシス実行因子カスパーゼ8のがん抑制因子としての機能解析Principal Investigator

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デスレセプターを介したアポトーシス誘導に関与するカスパーゼの機能解析Principal Investigator

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Sakamaki Kazuhiro 酒巻和弘

SAKAMAKI Kazuhiro 酒巻和弘

酒巻和宏サカマキカズヒロ