MATSUSHIMA Yoshitaka 松島芳隆

… Alternative Names

Matsushima Yoshitaka 松島芳隆

松島芳隆マツシマヨシタカ

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Researcher Number	20282816
Other IDs
Affiliation (Current)	2025: 東京農業大学, 応用生物科学部, 教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 東京農業大学, 応用生物科学部, 教授 2014 – 2016: 東京農業大学, 応用生物科学部, 教授 2009 – 2012: Hamamatsu University School of Medicine, 医学部, 准教授 2006 – 2007: Hamamatsu University School of Medicine, 医学部, 准教授 2005: 浜松医科大学, 医学部, 助教授 1999 – 2000: 東京工業大学, 大学院・理工学研究科, 助手
Review Section/Research Field	Principal Investigator Basic Section 38040:Bioorganic chemistry-related / Experimental pathology / Radiation science / Bioproduction chemistry/Bioorganic chemistry / Bioproduction chemistry/Bioorganic chemistry Except Principal Investigator Radiation science
Keywords	Principal Investigator 有機合成 / 抗トリパノソーマ原虫活性 / 殺ダニ活性 / 抗菌剤 / β-コスト酸 / ゼアレキシン / フィトアレキシン / トウモロコシ / 生物活性物質 / 窒素官能基 … More / タキソール / bis-イミダート / 窒素官能基の導入法 / 側鎖アミノ酸 / アミノアルコール / アミノアルコール / Cytoxazone / Amicoumacin / タキソールの側鎖アミノ酸 / 分子内共役付加反応 / 分子内環化 / 窒素官能基の導入 / トリクロロアセトイミダート / 塩基除去修復酵素 / 合成 / 脂質酸化物 / 塩基除去修復酵素 / がん / アミダイト / アダクトーム / DNA付加体 / PET / アルツハイマー / Sharpless asymmetric dihydroxylation / tolyposamine / vicenisamine / iodocyclisation / ristosamine / acosamine / daunosamine / trichloroacetimidate / intramolecular conjugate addition / antitumor antibiotic / vancomycin / vancosamine / dihydrooxazine / oxazoline / trichoroacetimidate / intramolecular conjugate additon / antibiotic / deoxyamino sugar / アミノ糖 / マクロラクタム / ケダロサミン / マイカロース / ビセニスタチンM / 抗腫瘍抗生物質 / ビセニサミン / ビセニスタチン … More Except Principal Investigator アポトーシス / 分子イメージング / 放射性薬品 / イメージングプローブ / ミトコンドリア膜電位 / ミトコンドリア / SPECT / PET / 腫瘍 / 放射性医薬品 Less

Synthetic studies on maize phytoalexins oriented towards antimicrobial applications.Principal Investigator
- Principal Investigator
  
  松島芳隆
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Tokyo University of Agriculture
Development of reactions based on trichloroacetimidate and synthetic studies of bioactive compoundsPrincipal Investigator
- Principal Investigator
  
  Matsushima Yoshitaka
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38040:Bioorganic chemistry-related
- Research Institution
  Tokyo University of Agriculture
Synthetic studies of DNA adducts and its amidites for DNA adductome analysis.Principal Investigator
- Principal Investigator
  
  Matsushima Yoshitaka
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo University of Agriculture
development of a novel imaging method for cancer therapy based on alteration of mitochondriafunction
- Principal Investigator
  
  MAGATA Yasuhiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  Hamamatsu University School of Medicine
Synthesis of a novel imaging agent aimed for preclinical diagnosisPrincipal Investigator
- Principal Investigator
  
  MATSUSHIMA Yoshitaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Hamamatsu University School of Medicine
抗生物質に見られるデオキシアミノ糖類の効率的合成法の確立と医薬創製への応用Principal Investigator
- Principal Investigator
  
  松島芳隆
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Hamamatsu University School of Medicine
新規抗腫瘍抗生物質ビセニスタチンの全合成およびその作用機構の解明Principal Investigator
- Principal Investigator
  
  松島芳隆
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Bioproduction chemistry/Bioorganic chemistry
- Research Institution
  Tokyo Institute of Technology

All 2024 2023 2022 2021 2017 2014 2012 2011 2010 2008 2006 2005

All Journal Article Presentation Patent

[Journal Article] Gram-scale synthesis of cytoxazone via dihydrooxazine formation through SiO2-promoted intramolecular substitution of a trichloroacetimidate2023
- Author(s)
  Matsushima Yoshitaka、Otsuka Kota、Ishikawa Moe、Akita Shu
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 131 Pages: 154786-154786
- DOI
  10.1016/j.tetlet.2023.154786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05867
[Journal Article] Concise synthesis of amino acid component of amicoumacins via dihydrooxazine formation through intramolecular conjugate addition2022
- Author(s)
  Matsushima Yoshitaka、Ogawa Yukako、Nishi Katsuya、Nakata Kyosuke
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 87 Issue: 2 Pages: 131-137
- DOI
  10.1093/bbb/zbac182
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05867
[Journal Article] Concise synthesis of the Taxol side chain and demethoxy-4-epi-cytoxazone via oxazoline formation through intramolecular benzylic substitution of a bis-trichloroacetimidate2021
- Author(s)
  Y. Matsushima, and M. Orita
- Journal Title
  
  Tetrahedron Letters
  
  Volume: 73 Pages: 153095-153095
- DOI
  10.1016/j.tetlet.2021.153095
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K05867
[Journal Article] Influence of GSH S-transferase on the mutagenicity induced by dichloromethane and 1,2-dichloropropane2017
- Author(s)
  N Akiba, K Shiizaki, Y Matsushima, O Endo, K Inaba and Y Totsuka
- Journal Title
  
  Mutagenesis
  
  Volume: 32 Issue: 4 Pages: 455-462
- DOI
  10.1093/mutage/gex014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460469, KAKENHI-PROJECT-15K06849
[Journal Article] Human DNA glycosylase enzyme TDG repairs thymine mispaired with exocyclic etheno-DNA adducts2014
- Author(s)
  Goto M, Shinmura K, Matsushima Y, Ishino K, Yamada H, Totsuka Y, Matsuda T, Nakagama H, Sugimura H
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 76 Pages: 136-146
- DOI
  10.1016/j.freeradbiomed.2014.07.044
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460476, KAKENHI-PROJECT-26460469, KAKENHI-PROJECT-26670187
[Journal Article] Robust quantitative assessments of cytosine modifications and changes in the expressions of related enzymes in gastric cancer.2014
- Author(s)
  Du C, Kurabe N, Matsushima Y, Suzuki M, Kahyo T, Ohnishi I, Tanioka F, Tajima S, Goto M, Yamada H, Tao H, Shinmura K, Konno H, Sugimura H.
- Journal Title
  
  Gastric Cancer.
  
  Volume: 14 Issue: 3 Pages: 409-409
- DOI
  10.1007/s10120-014-0409-4
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26670187, KAKENHI-PROJECT-26460469
[Journal Article] Novel Concise Synthesis of(±)-Noviose and L-(+)-Noviose by Palladium-Catalyzed Epoxide Opening Reaction2011
- Author(s)
  Y. Matsushima and J. Kino
- Journal Title
  
  SYNTHESIS
  
  Pages: 1290-1294
- Data Source
  KAKENHI-PROJECT-21591555
[Journal Article] Genetic susceptibility to lung cancer2011
- Author(s)
  H.Sugimura, H.Tao, M.Suzuki, H.Mori, M.Tsuboi, S.Matsuura, M.Goto, K.Shimnura, T.Ozawa, F.Tanioka, N.Sato, Yoshitaka Matsushima, S.Kageyama, K.Funai, P.-H.Chou, T.Matsuda
- Journal Title
  
  Front.Biosci.(Schol.Ed.)
  
  Volume: S3 Issue: 1 Pages: 1463-1477
- DOI
  10.2741/237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591555, KAKENHI-PROJECT-22790378, KAKENHI-PROJECT-221S0001
[Journal Article] Novel Concise Synthesis of (±)-Noviose and L-(+)-Noviose by Palladium-Catalyzed Epoxide Ooenine Reaction.2011
- Author(s)
  Yoshitaka Matsushima, J.Kino
- Journal Title
  
  SYNTHESIS
  
  Pages: 1290-1294
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591555
[Journal Article] Genetic susceptibility to lung cancer2011
- Author(s)
  H. Sugimura, H. Tao, M. Suzuki, H. Mori, M. Tsuboi, S. Matsuura, M. Goto, K. Shinmura, T. Ozawa, F. Tanioka, N. Sato, Y. Matsushima, S. Kageyama, K. Funai, P.-H. Chou, T. Matsuda
- Journal Title
  
  Front. Biosci
  
  Pages: 1463-1477
- Data Source
  KAKENHI-PROJECT-21591555
[Journal Article] Synthesis of N-Bz-Protected D-Daunosamine and D-Ristosamine by Silica Gel Promoted Intramolecular Conjugate Addition of Trichloroacetimidates obtained from Osmundalactone and its Epimer2010
- Author(s)
  Y. Matsushima and J. Kino
- Journal Title
  
  Eur. J. Org. Chem
  
  Pages: 2206-2210
- Data Source
  KAKENHI-PROJECT-21591555
[Journal Article] Synthesis and evaluation of new imaging agent for central nicotinic acetylcholine receptor α7 subtype.2010
- Author(s)
  M.Ogawa, S.Nishiyama, H.Tsukada, K.Hatano, T.Fuchigami, H.Yamaguchi, Yoshitaka Matsushima, K.Ito, Y.Magata
- Journal Title
  
  Nucl.Med.Biol.
  
  Volume: 37 Pages: 347-355
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591555
[Journal Article] Crystal Structures of Two Vancomycin Complexes with Phosphate and N-Acetyl-D-Ala. Structural Comparison between Low-Affinity and High-Affinity Ligand Complexes of Vancomycin2010
- Author(s)
  T. Kikuchi, S. Karki, I. Fujisawa, Y. Matsushima, Y. Nitanai, K. Aoki
- Journal Title
  
  Bull. Chem. Soc. Jpn
  
  Volume: 83 Pages: 391-400
- NAID
  10027173418
- Data Source
  KAKENHI-PROJECT-21591555
[Journal Article] Synthesis and evaluation of new imaging agent for central nicotinic acetylcholine receptorα7 subtype2010
- Author(s)
  M. Ogawa, S. Nishiyama, H. Tsukada, K. Hatano, T. Fuchigami, H. Yamaguchi, Y. Matsushima, K. Ito, Y. Magata
- Journal Title
  
  Nucl. Med. Biol
  
  Volume: 37 Pages: 347-355
- Data Source
  KAKENHI-PROJECT-21591555
[Journal Article] Synthesis of N-Bz-Protected D-Daunosamine and D-Ristosamine by Silica Gel Promoted Intramolecular Conjugate Addition of Trichloroacetimidates obtained from Osmundalactone and its Epimer2010
- Author(s)
  Y.Matsushima, J.Kino
- Journal Title
  
  Eur.J.Org.Chem.
  
  Pages: 2206-2201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591555
[Journal Article] Crystal Structures of Two Vancomycin Complexes with Phosphate and N-Acetyl-D-Ala. Structural Comparison between Low-Affinity and High-Affinity Ligand Complexes of Vancomycin2010
- Author(s)
  T.Kikuchi, S.Karki, I.Fujisawa, Y.Matsushima, Y.Nitanai, K.Aoki
- Journal Title
  
  Bull.Chem.Soc.Jpn. 83
  
  Pages: 391-400
- NAID
  10027173418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591555
[Journal Article] Intramolecular conjugate addition of γ-and δ-trichloroacetimidoyloyloxy-α,β-unsaturated esters in an acyclic systm2008
- Author(s)
  Yoshitaka Matsushima and Jun Kino
- Journal Title
  
  Tetrahedron 64
  
  Pages: 3943-3952
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17780089
[Journal Article] An intramolecular conjugate addition of γ-trichloroacetimidoyloxy-α, β-unsaturated esters: a very concise route to daunosamine, acosamine, ristosamine and 3-epi-daunosamine precursors2006
- Author(s)
  Yoshitaka Matsushima and Jun Kino
- Journal Title
  
  Tetrahedron Letters 47・49
  
  Pages: 8777-8780
- Data Source
  KAKENHI-PROJECT-17780089
[Journal Article] A new simple route to deoxyamino sugars from non-sugar material : synthesis of D-tolyposamine and 4-epi-D-tolyposamine and formal synthesis of D-vicenisamine2005
- Author(s)
  Yoshitaka Matsushima, Jun Kino
- Journal Title
  
  Tetrahedron Letters 46・49
  
  Pages: 8609-8612
- Data Source
  KAKENHI-PROJECT-17780089
[Patent] β－コストール及びβ－コスト酸の製造方法2023
- Inventor(s)
  松島芳隆、岩田幸介
- Industrial Property Rights Holder
  松島芳隆、岩田幸介
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-128996
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-23K05062
[Patent] オキサゾリン化合物の製法2006
- Inventor(s)
  松島芳隆
- Industrial Property Rights Holder
  浜松医科大学
- Industrial Property Number
  2006-206123
- Filing Date
  2006-07-28
- Data Source
  KAKENHI-PROJECT-17780089
[Patent] 診断用薬剤2006
- Inventor(s)
  間賀田泰寛、小川美香子、松島芳隆、塚田秀夫、籏野健太郎
- Industrial Property Rights Holder
  浜松医科大学
- Industrial Property Number
  2006-232386
- Filing Date
  2006-08-29
- Data Source
  KAKENHI-PROJECT-17780089
[Presentation] トウモロコシが産生するフィトアレキシンzealexin類の合成研究2024
- Author(s)
  栗原洸、石井航平、飯島章太、松島芳隆
- Organizer
  日本農芸化学会2024年度大会（東京）
- Data Source
  KAKENHI-PROJECT-23K05062
[Presentation] トリクロロアセトイミダートを用いた cytoxazone のグラムスケール合成2023
- Author(s)
  大塚皓太、石川萌、秋田柊、松島芳隆
- Organizer
  日本農芸化学会 2023年度（令和5年度）大会（広島）
- Data Source
  KAKENHI-PROJECT-20K05867
[Presentation] トリクロロアセトイミダートを用いた cytoxazone のグラムスケール合成2023
- Author(s)
  大塚皓太、石川萌、秋田柊、松島芳隆
- Organizer
  日本農芸化学会 2023年度大会（広島）
- Data Source
  KAKENHI-PROJECT-20K05867
[Presentation] トリクロロアセトイミダートを用いた cytoxazone の新規合成法の開発2022
- Author(s)
  大塚皓太、石川萌、秋田柊、松島芳隆
- Organizer
  日本農芸化学会関東支部 2022年度支部大会
- Data Source
  KAKENHI-PROJECT-20K05867
[Presentation] カーバマートのヨード環化反応を用いたデオキシアミノ糖類の新規合成法の開発2012
- Author(s)
  松島芳隆、記野順
- Organizer
  日本農芸化学会大会
- Place of Presentation
  京都(京都女子大学)
- Year and Date
  2012-03-24
- Data Source
  KAKENHI-PROJECT-21591555
[Presentation] カーバマートのヨード環化反応を用いたデオキシアミノ糖類の新規合成法の開発2012
- Author(s)
  松島芳隆、記野順
- Organizer
  日本農芸化学会大会
- Place of Presentation
  京都
- Year and Date
  2012-03-24
- Data Source
  KAKENHI-PROJECT-21591555
[Presentation] アミノクマリン系抗生物質ノボビオシンの構成デオキシ糖ノビオースの効率的合成2011
- Author(s)
  松島芳隆、記野順
- Organizer
  日本農芸化学会大会(東日本大震災の影響で直前に中止となったが、発表自体は成立している。)
- Place of Presentation
  京都(京都女子大学)
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-21591555
[Presentation] アミノクマリン系抗生物質ノボビオシンの構成デオキシ糖ノビオースの効率的合成2011
- Author(s)
  松島芳隆、記野順
- Organizer
  日本農芸化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-03-26
- Data Source
  KAKENHI-PROJECT-21591555
[Presentation] トリクロロアセトイミダートの分子内共役付加反応を用いたデオキシアミノ糖の合成2010
- Author(s)
  松島芳隆, 記野順
- Organizer
  日本農芸化学会大会
- Place of Presentation
  東京 (東京大学駒場キャンパス)
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21591555
[Presentation] トリクロロアセトイミダートの分子内共役付加反応を用いたデオキシアミノ糖の合成2010
- Author(s)
  松島芳隆、記野順
- Organizer
  日本農芸化学会大会
- Place of Presentation
  東京
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21591555
[Presentation] トリクロロアセトイミダートを基盤とした分子内共役付加反応2008
- Author(s)
  松島芳隆, 記野順
- Organizer
  日本農芸化学会2008年度大会
- Place of Presentation
  名城大学
- Year and Date
  2008-03-28
- Data Source
  KAKENHI-PROJECT-17780089

1. MAGATA Yasuhiro (20209399)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. KINO Jun (40262810)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
3. SAKAHARA Harumi (10187031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. OGAWA Mikako (20344351)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TAKASHIMA Misato (70525592)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SUGIMURA haruhiko (00196742)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 新村和也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MATSUSHIMA Yoshitaka 松島 芳隆

Matsushima Yoshitaka 松島 芳隆

松島 芳隆 マツシマ ヨシタカ

Research Projects

Research Products

Co-Researchers

Synthetic studies on maize phytoalexins oriented towards antimicrobial applications.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of reactions based on trichloroacetimidate and synthetic studies of bioactive compoundsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Synthetic studies of DNA adducts and its amidites for DNA adductome analysis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

development of a novel imaging method for cancer therapy based on alteration of mitochondriafunction

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis of a novel imaging agent aimed for preclinical diagnosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

抗生物質に見られるデオキシアミノ糖類の効率的合成法の確立と医薬創製への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

新規抗腫瘍抗生物質ビセニスタチンの全合成およびその作用機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Gram-scale synthesis of cytoxazone via dihydrooxazine formation through SiO2-promoted intramolecular substitution of a trichloroacetimidate2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Concise synthesis of amino acid component of amicoumacins via dihydrooxazine formation through intramolecular conjugate addition2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Concise synthesis of the Taxol side chain and demethoxy-4-epi-cytoxazone via oxazoline formation through intramolecular benzylic substitution of a bis-trichloroacetimidate2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Influence of GSH S-transferase on the mutagenicity induced by dichloromethane and 1,2-dichloropropane2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Human DNA glycosylase enzyme TDG repairs thymine mispaired with exocyclic etheno-DNA adducts2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Robust quantitative assessments of cytosine modifications and changes in the expressions of related enzymes in gastric cancer.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel Concise Synthesis of(±)-Noviose and L-(+)-Noviose by Palladium-Catalyzed Epoxide Opening Reaction2011

Author(s)

MATSUSHIMA Yoshitaka 松島芳隆

Matsushima Yoshitaka 松島芳隆

松島芳隆マツシマヨシタカ