KOKUBO Kenichi 小久保謙一

… Alternative Names

Researcher Number	20287965
Other IDs
External Links
Affiliation (Current)	2022: 北里大学, 医療衛生学部, 准教授
Affiliation (based on the past Project Information) *help	2022: 北里大学, 医療衛生学部, 准教授 2011 – 2020: 北里大学, 医療衛生学部, 准教授 2015: 北里大学, 医療衛生部, 准教授 2009 – 2010: Kitasato University, 医療衛生学部, 講師 1997: 早稲田大学, 理工学部, 助手
Review Section/Research Field	Principal Investigator Kidney internal medicine Except Principal Investigator Respiratory organ internal medicine / Basic Section 55060:Emergency medicine-related / Embryonic/Neonatal medicine / 生物・生体工学 / Emergency medicine
Keywords	Principal Investigator 生体適合性 / 血液透析膜 / 人工透析学 / 一酸化窒素ガス / 血小板活性化 / マウス透析システム / 超小型透析システム / アルブミン結合毒素 / 効率的除去 / インドキシル硫酸 … More Except Principal Investigator 水素 / 活性酸素 / 一酸化窒素 / 水素ガス / 人工腎臓 / ECMO（人工肺） / 非閉塞性肺疾患癌 / 肺線維症 / 呼吸器感染症 / その他・酸素障害 / 酸素障害 / 肺障害 / 酸素 / 活性酵素 / 一酸化窒素ガス / 吸入療法 / ARDS / 新生児低酸素性虚血性脳症 / 低体温療法 / 近赤外線分光法 / 脳血液量 / 脳内Hb酸素飽和度 / 新生仔豚 / 新生児仮死 / 近赤外光 / 脳内Ｈｂ酸素飽和度 / エダラボン / 低酸素性虚血性脳症 / 新生児 / 動物モデル / 脳波 / 透析 / 尿素 / イオン / 電気透析 / 抽出 / 界面活性剤 / キレート / Artificial kidney / Dialysis / Urea / Ion / Electrodialysis / Extraction / Surfactant / Chelate / 救命 / 救急医学 / 災害医学 / 集中治療 / 血液浄化 / 人工臓器 / ECMO / NO / 生体適合性 / 一酸化窒素（NO） / 抗凝固作用 / 臓器障害 Less

ECMOモデルにおける一酸化窒素および水素ガス添加による臓器障害の改善効果の検討
- Principal Investigator
  
  小林こず恵
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kitasato University
一酸化窒素（ＮＯ）による人工肺膜表面の生体適合性の改善
- Principal Investigator
  
  小林こず恵
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Kitasato University
Development of next-generation module for blood purification that can control antithrombotic properties by nitric oxide releasing material.Principal Investigator
- Principal Investigator
  
  Kokubo Kenichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kitasato University
Challenge to a portable blood purification system
- Principal Investigator
  
  MATSUDA Kenichi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Emergency medicine
- Research Institution
  University of Yamanashi
Ameliorating effects of nitric oxide and/or hydrogen gas inhalation on ARDS
- Principal Investigator
  
  KOBAYASHI Hirosuke
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kitasato University
The effects of hydrogen gas inhalation for hypoxic-ischemic encephalopathy in piglets.
- Principal Investigator
  
  Kusaka Takashi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Kagawa University
Removal of albumin-bound toxin and albumin refolding by electrical dialysis and artificial chaperonPrincipal Investigator
- Principal Investigator
  
  KOKUBO Kenichi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kitasato University
The effects of hydrogen gas breathing on the lung injury induced by hyperoxia
- Principal Investigator
  
  KOBAYASHI Hirosuke
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kitasato University
Improvement of biocompatibility of dialysis membrane by nitric oxide or hydrogenPrincipal Investigator
- Principal Investigator
  
  KOKUBO Kenichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Kitasato University
Ion Selective Transport Across Liquid Membrane Mimicking Renal Tubule Function
- Principal Investigator
  
  SAKAI Kiyotaka
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  生物・生体工学
- Research Institution
  Waseda University

All 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Other

All Journal Article Presentation Book Patent

[Book] 各種治療モードとその特徴2012
- Author(s)
  小久保謙一, 酒井清孝, 峰島三千男
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-21591060
[Book] 生体と医用材料の相互作用,臨床工学講座生体物性・医用材料工学2010
- Author(s)
  小久保謙一.氏平政伸, 中島章夫
- Publisher
  医歯薬
- Data Source
  KAKENHI-PROJECT-21591060
[Book] 血液透析の原理と構成2010
- Author(s)
  小久保謙一.竹澤慎吾, 出渕靖志
- Publisher
  医歯薬
- Data Source
  KAKENHI-PROJECT-21591060
[Journal Article] 血液浄化器と治療法の変遷2017
- Author(s)
  8.小久保謙一, 小林こず恵, 小林弘祐, 松田兼一, 酒井清孝
- Journal Title
  
  人工臓器
  
  Volume: 46 Pages: 42-49
- NAID
  130006078655
- Data Source
  KAKENHI-PROJECT-15H05005
[Journal Article] Support for Dialysis Therapy in Vietnam, Cambodia, and Myanmar by Japanese Societies in the Field of Blood Purification2017
- Author(s)
  Kokubo Kenichi、Kobayashi Kozue、Urabe Sunichiro、Matsubara Hirokazu、Naramura Tomotaka、Wakai Haruki、Naganuma Toshihide、Nakajima Fumitaka、Shibahara Nobuhisa、Hyodo Toru、Matsuda Kenichi、Yoshida Kazunari、Yamashita Akihiro C.、Kawanishi Hideki
- Journal Title
  
  Blood Purification
  
  Volume: 44 Pages: 55-61
- DOI
  10.1159/000479621
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05005
[Journal Article] 可搬型小型血液浄化システム．2016
- Author(s)
  松田兼一,森口武史,菅原久徳,後藤順子,山根隆志,小久保謙一,栗原佳孝,小林こず恵,山本健一郎，丸山修
- Journal Title
  
  救急医学
  
  Volume: 40 Pages: 1439-1446
- Data Source
  KAKENHI-PROJECT-15H05005
[Journal Article] Challenge to the next stage of artificial kidney.2016
- Author(s)
  Matsuda K, Moriguchi T, Yamane T, Kokubo K, Yamamoto K
- Journal Title
  
  Int J Artif Organs
  
  Volume: 39 Pages: 323-323
- Data Source
  KAKENHI-PROJECT-15H05005
[Journal Article] 細径化したファイバを用いたヘモフィルタの開発2015
- Author(s)
  栗原佳孝, 小久保謙一, 小林こず恵, 後田洋輔, 塚尾浩, 柳沢政彦, 後藤順子, 針井則一, 森口武史, 松田兼一, 小林弘祐
- Journal Title
  
  医工学治療
  
  Volume: 27 Pages: 44-47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H05005
[Journal Article] Breathing Nitric Oxide plus Hydrogen Gas Reduces Ischemia-Reperfusion Injury and Nitrotyrosine Production in Murine Heart.2013
- Author(s)
  Shinbo T, Kokubo K, Sato Y, Hagiri S, Hataishi R, Hirose M, Kobayashi H
- Journal Title
  
  Am J Physiol Heart Circ Physiol.
  
  Volume: 4
- DOI
  10.1152/ajpheart.00844.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461166
[Journal Article] Ectopic expression of a T-box transcription factor, eomesodermin, renders CD4+Th cells cytotoxic by activating both perforin-and FasLpathways2012
- Author(s)
  Eshima E, Chiba S, Suzuki H, Kokubo K, Kobayashi H, Iizuka M, Iwabuchia K, Shinohara N
- Journal Title
  
  Immunology Letters
  
  Volume: 144 Pages: 7-15
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591002
[Journal Article] X-ray radiation causes electromagnetic interference in implantable cardiac pacemakers2010
- Author(s)
  Hirose M, Tachikawa K, Ozaki M, Umezawa N, Shinbo T, Kokubo K, Kobayashi H
- Journal Title
  
  Pacing Clin Electrophysiol
  
  Volume: 33 Pages: 1174-1181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591002
[Journal Article] Removal of an endotoxin fragment(Lipid A) by an endotoxin-retentive filter2010
- Author(s)
  Kokubo K, Futatsugi K, Tsukao H, Shinbo T, Hirose M, Kobayashi H
- Journal Title
  
  Desalination and Water Treatment
  
  Volume: 17 Pages: 25-30
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591002
[Journal Article] Respiratory Rhythms in Healthy Subjects and Patients2010
- Author(s)
  Shimane M, Tomita Y, Shinbo T, Kokubo K, Hirose M, Hataishi R, Kubota M, Masuda N, Kobayashi H
- Journal Title
  
  Advances in Experimental Medicine & Biology
  
  Volume: 662 Pages: 133-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591002
[Journal Article] Potential utility of HOP homeobox gene promoter methylation as a marker of tumor aggressiveness in gastric cancer2010
- Author(s)
  Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Kokubo K, KobayashiH, Kim M S, Sidransky D, Watanabe M
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 3263-327
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591002
[Journal Article] Macrophages that survive hyperoxia exposure have higher superoxide dismutase activities in their mitochondria2010
- Author(s)
  Kokubo K, Soeda S, Shinbo T, Hirose M, Fuku N, Nishigaki Y, Tanaka M, Kobayashi H
- Journal Title
  
  Adv Exp Med Biol
  
  Volume: 662 Pages: 63-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591002
[Journal Article] Clinical score and transcript abundance patterns identify Kawasaki disease patients who may benefit from addition of methylprednisolone2009
- Author(s)
  Ogata S, Ogihara Y, Nomoto K, Akiyama K, Nakahata Y, Sato K, Minoura K, Kokubo K, Kobayashi H, Ishii M
- Journal Title
  
  Pediatric Research
  
  Volume: 66 Pages: 577-584
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591002
[Journal Article] Low frequency oscillometry parameters in COPD patients are less variable during inspiration than during expiration2009
- Author(s)
  Kubota M, Shirai G, Nakamori T, Kokubo K, Masuda N, Kobayashi H
- Journal Title
  
  Respir Physiol Neurobiol.
  
  Volume: 166 Pages: 73-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591002
[Patent] 血液浄化器2017
- Inventor(s)
  松田兼一，小久保謙一，小林弘祐，春原隆司，野田澤俊介，福島浩
- Industrial Property Rights Holder
  国立大学法人山梨大学、学校法人北里研究所、ニプロ株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2017-02-03
- Overseas
- Data Source
  KAKENHI-PROJECT-15H05005
[Patent] 血液浄化器2017
- Inventor(s)
  松田兼一，小久保謙一，小林弘祐，春原隆司，野田澤俊介，福島浩
- Industrial Property Rights Holder
  国立大学法人山梨大学、学校法人北里研究所、ニプロ株式会社
- Industrial Property Rights Type
  特許
- Filing Date
  2017-01-06
- Overseas
- Data Source
  KAKENHI-PROJECT-15H05005
[Patent] アルブミン結合毒素除去装置2014
- Inventor(s)
  小久保謙一, 小林弘祐, 小林こず恵
- Industrial Property Rights Holder
  学校法人北里研究所
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-091968
- Filing Date
  2014-04-25
- Data Source
  KAKENHI-PROJECT-24591238
[Patent] 虚血再潅流障害軽減用治療剤および治療装置2010
- Inventor(s)
  小林弘祐,小久保謙一,新保年弘
- Industrial Property Rights Holder
  学校法人北里研究所
- Industrial Property Number
  2010-053405
- Filing Date
  2010-03-10
- Data Source
  KAKENHI-PROJECT-21591002
[Patent] 虚血再潅流障害軽減用治療剤および治療装置2010
- Inventor(s)
  小林弘祐、小久保謙一、新保年弘
- Industrial Property Rights Holder
  学校法人北里研究所
- Industrial Property Number
  2010-053405
- Filing Date
  2010-03-10
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] SUPPRESSION OF BLOOD COAGULATION ON THE SURFACE OF A DIALYSIS MEMBRANE USING A NITRIC OXIDE-CONTAINING DIALYSATE2019
- Author(s)
  Kenichi Kokubo, Kozue Kobayashi, Kenya Kohagura, Yuhei Yoshida, Hirosuke Kobayashi
- Organizer
  56th Congress of the European Renal Association (ERA) and European Dialysis and Transplant Association (EDTA)
- Data Source
  KAKENHI-PROJECT-16K09653
[Presentation] 私の考えるHPM：長期間使用可能な人工膜という側面から2018
- Author(s)
  小久保謙一
- Organizer
  ハイパフォーマンス・メンブレン研究会
- Data Source
  KAKENHI-PROJECT-16K09653
[Presentation] 透析液に付加した一酸化窒素による血液透析膜の表面の抗血栓性の改善2018
- Author(s)
  古波蔵賢弥, 吉田裕平, 小林こず恵, 小久保謙一, 小林弘祐
- Organizer
  第45回日本血液浄化技術学会学術大会・総会
- Data Source
  KAKENHI-PROJECT-16K09653
[Presentation] 可搬型小型血液浄化システムへの挑戦2017
- Author(s)
  20.松田兼一，森口武史，菅原久徳，後藤順子，小久保謙一，栗原佳孝，植木駿一，小林こず恵，守田憲崇，山根隆志，湯浅若菜，多儀篤真，山本健一郎
- Organizer
  第55回日本人工臓器学会大会
- Data Source
  KAKENHI-PROJECT-15H05005
[Presentation] 可搬型・小型血液浄化システムの臨床応用への挑戦（第2報）2016
- Author(s)
  松田兼一，森口武史，山根隆志，小久保謙一，山本健一郎
- Organizer
  第38回日本呼吸療法医学会学術集会
- Place of Presentation
  名古屋国際会議場（愛知県，名古屋市）
- Year and Date
  2016-07-07
- Invited
- Data Source
  KAKENHI-PROJECT-15H05005
[Presentation] Challenge to the Next Stage of Artificial Kidney．2016
- Author(s)
  Matsuda K, Moriguchi T, Yamane T, Kokubo K, Yamamoto K
- Organizer
  43rd Annual Congress of ESAO in Warsaw
- Place of Presentation
  ワルシャワ（ポーランド）
- Year and Date
  2016-09-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05005
[Presentation] 細径化した中空糸を使用したヘモフィルタの特性2016
- Author(s)
  栗原佳孝, 植木駿一, 渡部紗己, 後田洋輔, 塚尾浩, 小林こず恵, 小久保謙一, 森口武史, 松田兼一, 小林弘祐
- Organizer
  日本医工学治療学会第32回学術大会
- Place of Presentation
  山梨県甲府市
- Year and Date
  2016-03-19
- Invited
- Data Source
  KAKENHI-PROJECT-15H05005
[Presentation] 可搬型血液浄化システムの実現に向けて．2016
- Author(s)
  松田兼一，森口武史，菅原久徳，後藤順子，山根隆志，小久保謙一，栗原佳孝，小林こず恵，山本健一郎
- Organizer
  第54回日本人工臓器学会大会
- Place of Presentation
  米子コンベンションセンター（鳥取県，米子市）
- Year and Date
  2016-11-25
- Invited
- Data Source
  KAKENHI-PROJECT-15H05005
[Presentation] Effects of nitric oxide and hydrogen gas on mitochondrial respiration after anoxiareoxygenation.2016
- Author(s)
  Ikeda R, Hoshi A, Shimoda J, Kobayashi K, Kokubo K, Kobayashi H.
- Organizer
  The 9th Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  宮城県仙台市（仙台国際センター）
- Year and Date
  2016-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461166
[Presentation] Challenge to implantable blood purification equipment development.2016
- Author(s)
  Matsuda K, Moriguchi T, Yamane T, Kokubo K, Yamamoto K
- Organizer
  34th Congress of the International Society of Blood Purification
- Place of Presentation
  広島国際会議場（広島県，広島市）
- Year and Date
  2016-09-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05005
[Presentation] 可搬型小型血液浄化装置開発への挑戦2015
- Author(s)
  松田兼一，山根隆志，小久保謙一，峰島三千男，山本健一郎
- Organizer
  第37回日本呼吸療法医学会学術集会
- Place of Presentation
  京都府京都市
- Year and Date
  2015-07-17
- Invited
- Data Source
  KAKENHI-PROJECT-15H05005
[Presentation] 細径の中空糸を用いた小型血液浄化器の長時間安定施行条件の検討2015
- Author(s)
  栗原佳孝, 渡部紗己, 後田洋輔, 塚尾浩, 小林こず恵, 小久保謙一, 柳沢政彦, 後藤順子, 針井則一, 森口武史, 松田兼一, 小林弘祐
- Organizer
  第42回血液浄化技術学会学術大会・総会
- Place of Presentation
  東京都新宿区
- Year and Date
  2015-04-25
- Data Source
  KAKENHI-PROJECT-15H05005
[Presentation] Optimum filtration flow rate of newly developed 100-micron hollow fibre hemofilter2015
- Author(s)
  栗原佳孝，小久保謙一，小林こず恵，塚尾浩，森口武史，松田兼一，小林弘祐
- Organizer
  42th Annual EASO Conference
- Place of Presentation
  ベルギー，ルーベン
- Year and Date
  2015-09-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H05005
[Presentation] インドキシル硫酸のアルブミンへの吸着動態解析2014
- Author(s)
  鈴木駿平, 小林こず恵, 小久保謙一, 栗原佳孝, 塚尾浩, 小林弘祐
- Organizer
  第59回日本透析医学会学術集会・総会
- Place of Presentation
  神戸国際会議場(兵庫県神戸市)
- Data Source
  KAKENHI-PROJECT-24591238
[Presentation] インドキシル硫酸のアルブミンへの吸着動態解析2014
- Author(s)
  鈴木駿平, 小久保謙一, 栗原佳孝, 塚尾浩, 小林弘祐
- Organizer
  第29回ハイパフォーマンスメンブレン研究会
- Place of Presentation
  日本消防会館ニッショーホール( 東京都港区)
- Data Source
  KAKENHI-PROJECT-24591238
[Presentation] ﾏｳｽ心筋虚血、再灌流障害ﾓﾃﾞﾙに対する水素、一酸化窒素同時吸入の保護効果2013
- Author(s)
  佐藤友理、新保年弘、小久保謙一、羽切慎太郎、畑石隆治、益田典幸、小林弘祐
- Organizer
  第13回日本NO学会
- Place of Presentation
  沖縄県医師会館（沖縄県南風原町）
- Data Source
  KAKENHI-PROJECT-25461166
[Presentation] 誤嚥性肺炎ﾏｳｽﾓﾃﾞﾙにおける肺障害の水素吸入による低減2013
- Author(s)
  西川優希、小久保謙、畑石隆治、益田典幸、小林弘祐
- Organizer
  第4回分子状水素医学ｼﾝﾎﾟｼﾞｳﾑ
- Place of Presentation
  きゅりあん小ホール（東京都品川区）
- Data Source
  KAKENHI-PROJECT-25461166
[Presentation] 電気透析法および電気泳動法を利用したアルブミン結合毒素の効率的な除去2012
- Author(s)
  小久保謙一、園部富裕、白鳥貴恵、鈴木英行、喜渡純平、塚尾浩、新保年弘、廣瀬稔、小林弘祐
- Organizer
  第39回日本血液浄化技術学会学術大会・総会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-24591238
[Presentation] Dialysate containing nitric oxide suppresses platelet activation on the surface of dialysis membrane2012
- Author(s)
  Kokubo K, Urabe S, Hanada S, Ebine T, Tsukao H, Shinbo T, Hirose M, Kobayashi H
- Organizer
  7th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  Edinburgh, UK
- Data Source
  KAKENHI-PROJECT-21591060
[Presentation] 心筋虚血-再灌流障害に対する水素・一酸化窒素併用吸入の効果2012
- Author(s)
  佐藤友理, 新保年弘, 畑石隆治, 小久保謙一, 廣瀬稔, 小林弘祐
- Organizer
  第2回分子状水素医学シンポジウム
- Place of Presentation
  北里大学白金キャンパス(東京)
- Year and Date
  2012-02-11
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Suppression of platelet activation on the surface of dialysis membrane using nitric oxide containing dialysate2011
- Author(s)
  Urabe S, Kokubo K, Tsukao H, Shinbo T, Hirose M, Kobayashi H
- Organizer
  47th ERA-EDTA Congress
- Place of Presentation
  Prague, Czech republic
- Data Source
  KAKENHI-PROJECT-21591060
[Presentation] 一酸化窒素供与体を用いた血液透析における血小板凝集の抑制2011
- Author(s)
  浦辺俊一郎, 小久保謙一, 塚尾浩, 新保年弘, 廣瀬稔, 小林弘祐
- Organizer
  日本医工学治療学会第27回学術大会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21591060
[Presentation] 一酸化窒素供与体を用いた血液透析における血小板凝集の抑制2011
- Author(s)
  浦辺俊一郎, 小久保謙一, 塚尾浩, 新保年弘, 廣瀬稔, 小林弘祐
- Organizer
  日本医工学治療学会第27回学術大会
- Place of Presentation
  岡山コンベンションセンター(岡山)
- Data Source
  KAKENHI-PROJECT-21591060
[Presentation] 誤嚥性肺炎マウスモデルにおける肺障害および遠隔臓器障害への水素吸入の効果2011
- Author(s)
  畑石隆治, 西川優希, 新保年弘, 佐藤友里, 野田健太郎, 小久保謙一, 益田典幸, 小林弘祐
- Organizer
  第5回iPUC-II (Integrated Pulmonary Circulation Research-II)
- Place of Presentation
  東京ステーションコンファレンス(東京)
- Year and Date
  2011-06-25
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Increased surface coverage area of polyvinylpyrrolidone on polysulfone hemofilter membrane improves biocompatibility by suppressing cell adhesion during continuous hemofiltration2011
- Author(s)
  Kurihara Y, Kokubo K, Tsukao H, Shinbo T, Hirose M, Kobayashi H
- Organizer
  16th International Conference on Continuous Renal Replacement Therapies CRRT2001
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Suppression of platelet activation on the surface of dialysis membrane using nitric oxide containing dialysate2011
- Author(s)
  Urabe S, Kokubo K, Tsukao H, Shinbo T, Hirose M, Kobayashi H
- Organizer
  47^<th> ERA-EDTA Congress
- Place of Presentation
  Prague Congress Centre (Prague, Czech republic)
- Data Source
  KAKENHI-PROJECT-21591060
[Presentation] Urea concentrating ability of artificial renal tubule based on countercurrent multiplier system using electrodialysis, dialysis and filtration2010
- Author(s)
  Harashima T, Otani Y, Kokubo K, Tsukao H, Shinbo T, Hirose M, Sakai K, Kobayashi H
- Organizer
  World Conference on portable-wearable and miniaturized systems for dialysis and ultrafiltration and 3rd Annual Congress of the International Society for hemodialysis
- Place of Presentation
  Vicenza, Italy
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Comparison of the effects of the dilution mode on inflammation and lymphocyte function between predilution and postdilution hemodiafiltration2010
- Author(s)
  Sakurai K, Saito T, Kokubo K, Asahi D, Yamauchi F, Hosoya H, Maruyama N, Kobayashi H
- Organizer
  47th ERA-EDTA Congress
- Place of Presentation
  Munich
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Simultaneous inhalation of nitric oxide and hydrogen reduces infarct size in the mouse model of myocardial ischemia-reperfusion injury2010
- Author(s)
  Shinbo T, Sato Y, Hataishi R, Kokubo K, Hirose M, Kobayashi H
- Organizer
  6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Dialysis membrane releasing nitric oxide from dialysate side increases cyclic guanosine monophosphate in platelets and suppresses the activation of platelets on the surface2010
- Author(s)
  Kokubo K, Urabe S, Tsukao H, Shinbo T, Hirose M, Kobayashi H
- Organizer
  6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Dialysis membrane releasing nitric oxide from dialysate side increases cyclic guanosine monophosphate in platelets and suppresses the activation of platelets on the surface.2010
- Author(s)
  Kenichi Kokubo, Shunichiro Urabe, Hiroshi Tsukao, Toshihiro Shinbo, Minoru Hirose, Hirosuke Kobayashi
- Organizer
  6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  国立京都国際会館,京都
- Data Source
  KAKENHI-PROJECT-21591060
[Presentation] Activation of platelets in contact with oxidized vitamin E-coated surface2010
- Author(s)
  Tsukao H, Kokubo K, Nagasato M, Shinbo T, Hirose M, Kobayashi H
- Organizer
  47th ERA-EDTA Congress
- Place of Presentation
  Munich
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Inhaled hydrogen during mechanical ventilation and hydrogen generated by enterobacterial flora reduce infarct size in the mouse model of myo-cardial ischemia-reperfusion injury.2010
- Author(s)
  Sato Y, Shinbo T, Hataishi R, Kokubo K, Hirose M, Kobayashi H.
- Organizer
  European Respiratory Society Annual Congress 2010
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Suppression of platelet Activation on the surface of dialysis membrane releasing nitric oxide from the dialysate2010
- Author(s)
  Urabe S, Kokubo K, Tsukao H, Shinbo T, Hirose M, Kobayashi H
- Organizer
  47th ERA-EDTA Congress
- Place of Presentation
  Munich
- Data Source
  KAKENHI-PROJECT-21591060
[Presentation] Simultaneous inhalation of nitric oxide and hydrogen reduces infarct size in the mouse model of myocardial ischemia- reperfusion injury.2010
- Author(s)
  Shinbo T, Sato Y, Hataishi R, Kokubo K, Hirose M, Kobayashi H
- Organizer
  6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  国際会館(Kyoto)
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Dialysate-based perfusate of low viscosity is suitable for normothermic ex vivo lung perfusion2010
- Author(s)
  Noda K, Kokubo K, Shinbo T, Hirose M, Kobayashi H
- Organizer
  ERS Annual Congress 2010
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Differentiation of side population cells isolated from human amniotic mesenchymal cell into vascular endothelial cells under hypoxic condition2010
- Author(s)
  Maruyama N, Nishikubo Y, Kokubo K, Shinbo T, Hirose M, Kobayashi M, Sakuragawa N, Kobayashi H
- Organizer
  Tissue Engineering & Regenerative Medicine International Society 2010 Asia Pacific meeting, TERMIS-AP 2010 Annual Conference
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Dialysis membrane releasing nitric oxide from dialysate side increases cyclic guanosine monophosphate in platelets and suppresses the activation of platelets on the surface2010
- Author(s)
  Kokubo K, Urabe S, Tsukao H, Shinbo T, Hirose M, Kobayashi H
- Organizer
  6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-21591060
[Presentation] Temporal changes in gene expressions and cytokine productions caused by stretching of normal human pulmonary artery endothelial cells2010
- Author(s)
  Kobayashi K, Tanaka M, Inaoka H, Nebuya S, Fukuoka Y, Kokubo K, Kobayashi H, Noshiro M
- Organizer
  European Respiratory Society Annual Congress 2010
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Differentiation into neural cells from human amniotic mesenchymal cell in serum free medium2010
- Author(s)
  Nishikubo Y, Maruyama N, Kokubo K, Shinbo T, Hirose M, Kobayashi M, Sakuragawa N, Kobayashi H
- Organizer
  Tissue Engineering & Regenerative Medicine International Society 2010 Asia Pacific meeting, TERMIS-AP 2010 Annual Conference
- Place of Presentation
  Sydney, Australia
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Hydrogen protects alveolar epithelial cells(A549)against injury induced by reactive oxygen species in vitro.2010
- Author(s)
  Kokubo K, Yamashita K, Shinbo T, Hirose M, Kobayashi H.
- Organizer
  European Respiratory Society Annual Congress 2010
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Inhaled hydrogen during mechanical ventilation and hydrogen generated by enterobacterial flora reduce infarct size in the mouse model of myocardial ischemia-reperfusion injury2010
- Author(s)
  Sato Y, Shinbo T, Hataishi R, Kokubo K, Hirose M, Kobayashi H
- Organizer
  European Respiratory Society Annual Congress 2010
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Suppression of platelet Activation on the surface of dialysis membrane releasing nitric oxide from the dialysate2010
- Author(s)
  Urabe S, Kokubo K, Tsukao H, Shinbo T, Hirose M, Kobayashi H
- Organizer
  47th ERA-EDTA Congress
- Place of Presentation
  Munich
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Hydrogen protects alveolar epithelial cells(A549) against injury induced by reactive oxygen species in vitro2010
- Author(s)
  Kokubo K, Yamashita K, Shinbo T, Hirose M, Kobayashi H
- Organizer
  European Respiratory Society Annual Congress 2010
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-21591002
[Presentation] Suppression of platelet Activation on the surface of dialysis membrane releasing nitric oxide from the dialysate.2010
- Author(s)
  Shunichiro Urabe, Kenichi Kokubo, Hiroshi Tsukao, Toshihiro Shinbo, Minoru Hirose, Hirosuke Kobayashi
- Organizer
  47^<th> ERA-EDTA Congress
- Place of Presentation
  International Congress Centre Munich, Munich, Germany
- Data Source
  KAKENHI-PROJECT-21591060
[Presentation] Hydrogen concentration in expiratory gas after taking indigestible sugars.
- Author(s)
  Kokubo K, Aoki M, Kobayashi K, Shimouchi A, Kobayashi H.
- Organizer
  The 19th Congress of Asian Pacific Society of Respirology (APSR),
- Place of Presentation
  ﾇｻﾄﾞｳｱ、ｺﾝﾍﾞﾝｼｮﾝｾﾝﾀｰ(Bali,Indonesia)
- Year and Date
  2014-11-13 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-25461166
[Presentation] Hydrogen gas inhalation ameliorates direct lung injury and indirect contralateral lung injury in a murine aspiration pneumonia model
- Author(s)
  Nishikawa Y, Kokubo K, Kobayashi K, Hataishi R, Shinbo T, Hirose M, Kobayashi H.
- Organizer
  The 19th Congress of Asian Pacific Society of Respirology (APSR), 2014.11.13-16, Bali, Indonesia)
- Place of Presentation
  ﾇｻﾄﾞｳｱ、ｺﾝﾍﾞﾝｼｮﾝｾﾝﾀｰ(Bali,Indonesia)
- Year and Date
  2014-11-13 – 2014-11-16
- Data Source
  KAKENHI-PROJECT-25461166
[Presentation] ミトコンドリアの酸素消費速度に及ぼす水素ガスの影響
- Author(s)
  小久保謙一, 下田純平, 栗原佳孝, 小林こず恵, 小林弘祐
- Organizer
  第5回分子状水素医学シンポジウム
- Place of Presentation
  ウインクあいち（名古屋）
- Year and Date
  2015-03-21 – 2015-03-22
- Data Source
  KAKENHI-PROJECT-25461166

1. KOBAYASHI Hirosuke (70153632)

# of Collaborated Projects: 6 results

# of Collaborated Products: 47 results
2. 小林こず恵 (60448975)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. SHINBO Toshihiro (10406910)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
4. KUBOTA Masaru (00234500)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. HIROSE Minoru (50286382)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
6. HATAISHI Ryuji (20276124)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
7. FUJII Shigemoto (00325333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. AKAIKE Takaaki (20231798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Kusaka Takashi (50274288)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SAKAI Kiyotaka (00063727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MATSUDA Kenichi (60282480)

# of Collaborated Projects: 1 results

# of Collaborated Products: 14 results
12. 安田真之 (00380155)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 久保井徹 (00437683)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 小谷野耕佑 (20437685)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 岡田仁 (30253272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 三木崇範 (30274294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 岩瀬孝志 (30284368)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 上野正樹 (30322267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 中村信嗣 (30437686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 岡崎薫 (40648614)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 山本健一郎 (00434316)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
22. 山根隆志 (10358278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
23. 森口武史 (60422680)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
24. 後藤順子 (60530102)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
25. 菅原久徳 (70746776)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
26. 針井則一 (80377522)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
27. 柳沢政彦 (90597022)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
28. 塚尾浩 (10584972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOKUBO Kenichi 小久保 謙一

小久保 謙一 コクボ ケンイチ

Research Projects

Research Products

Co-Researchers

ECMOモデルにおける一酸化窒素および水素ガス添加による臓器障害の改善効果の検討

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

一酸化窒素（ＮＯ）による人工肺膜表面の生体適合性の改善

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of next-generation module for blood purification that can control antithrombotic properties by nitric oxide releasing material.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Challenge to a portable blood purification system

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ameliorating effects of nitric oxide and/or hydrogen gas inhalation on ARDS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effects of hydrogen gas inhalation for hypoxic-ischemic encephalopathy in piglets.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Removal of albumin-bound toxin and albumin refolding by electrical dialysis and artificial chaperonPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effects of hydrogen gas breathing on the lung injury induced by hyperoxia

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Improvement of biocompatibility of dialysis membrane by nitric oxide or hydrogenPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Ion Selective Transport Across Liquid Membrane Mimicking Renal Tubule Function

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 各種治療モードとその特徴2012

Author(s)

Publisher

Data Source

[Book] 生体と医用材料の相互作用,臨床工学講座生体物性・医用材料工学2010

Author(s)

Publisher

Data Source

[Book] 血液透析の原理と構成2010

Author(s)

Publisher

Data Source

[Journal Article] 血液浄化器と治療法の変遷2017

Author(s)

Journal Title

KOKUBO Kenichi 小久保謙一

小久保謙一コクボケンイチ