INOUE Hiroshi 井上寛

Researcher Number	20294639
External Links
Affiliation (based on the past Project Information) *help	2014: 徳島大学, 疾患プロテオゲノム研究センター, 講師 2013 – 2014: 徳島大学, 学内共同利用施設等, 講師 2011 – 2012: 徳島大学, 疾患プロテオゲノム研究センター, 学術研究員 2011: 徳島大学, 疾患ゲノム研究センター, 特任教授 2008: 徳島大学, 疾患ゲノム研究センター, 准教授 … More 2007: 徳島大学, ゲノム機能研究センター, 准教授 2004 – 2006: 徳島大学, ゲノム機能研究センター, 助教授 1997 – 2001: 山口大学, 医学部・附属病院, 助手 2000: 山口大, 医学部附属病院, 助手 1998: 山口大学, 医学部附属病院, 助手 Less
Review Section/Research Field	Principal Investigator Pediatrics / Metabolomics Except Principal Investigator Metabolomics / Metabolomics / Bacteriology (including Mycology) / Pathological medical chemistry / 内分泌・代謝学 / Pediatrics / Endocrinology
Keywords	Principal Investigator GWAS / 下垂体特異的転写因子Pit-1 / GH放出ホルモン受容体遺伝子 / グレリン受容体遺伝子 / 遺伝子変異 / 低身長症 Except Principal Investigator QTL / インスリン / 糖尿病 / 疾患感受性遺伝子 … More / 2型糖尿病 / small RNA / fat pad weight / animal model of diabetes / susceptibility gene / congenic mice / 内臓脂肪量 / 動物モデル / コンジェニックマウス / Lepr^<db>マウス / PDK1 / Akt1 / GLUT4 / 遺伝子 / 難聴 / HNF-1α / 小胞体 / 視神経萎縮 / Wolfram症候群 / persistent hyperinsulinemic hypoglycemia of infancy / Wolfram syndrome / glucose transport / insulin / diabetes mellitus / インスリン分泌 / 新生児低血糖症 / PI3キナーゼ / 糖輸送 / アデノウイルスベクター / 遺伝子変異 / ERストレス / feeding volume / type 2 diabetes / Lepr^<db> mice / 内蔵脂肪量 / 高脂肪食負荷 / 節餌量 / 糖尿病動物モデル / virulence factor / post transcriptional regulation / translation / Vibrio parahaemolyticus / 病原因子 / 翻訳後調節 / 翻訳 / 腸炎ビブリオ / congenic sub-line / type 2 diabetes mellitus / Lep^<db> mice / 修飾遺伝子 / サブコンジェニックマウス / Optic Atrophy / ER stress / Mutation / Endoplasmic Reticulum / Diabetes Mellitus / Wolfram Syndrome / in situ hybridization / PI3 kinase / Insulin / PH domain / Akt / endoplasmic reticulum / PAX-4 / optic atrophy / MODY / 転写因子 / Wolframの症候群 / Pax4 / sulfonylurea receptor / PI3-kinase / adenovirus vector / ウイルスベクター / アデノウイルス / グリセロリン酸シャトル / GKラット / 遺伝子治療 / hepatocyte nuclear factor / 遺伝子導入 / 膵β細胞 / ウオルフラム症候群 / スルフォニル尿素受容体 / GH放出ホルモン受容体遺伝子 / グレリン受容体遺伝子 / 低身長症 / 細胞内局在 / 遺伝子導入法 / 遺伝子発現量 / ENDOG遺伝子 / アポトーシス / ポリクローナル抗体 / 遣伝子発現量 / ミトコンドリア / ENDOGL1遺伝子 / 疾患感受性候補遺伝子 Less

Genetic identification and functional analysis in Japanese families with a short stature
- Principal Investigator
  
  ITAKURA Mitsuo
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokushima
日本人小児低身長症の疾患関連遺伝子同定と分子機構の解明Principal Investigator
- Principal Investigator
  
  井上寛
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  The University of Tokushima
Functional analysis of theENDOGL1 gene as a candidate disease susceptibility gene for T2D by rentivirus vector
- Principal Investigator
  
  ITAKURA Mitsuo
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Endocrinology
- Research Institution
  The University of Tokushima
Regulatory mechanisms of production of virulence factor in Vibrio parahaemolyticus
- Principal Investigator
  
  TAKAHASHI Akira
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  The University of Tokushima
Mapping of susceptibility genes to diabetes by high fat diet following QTL analysis of diabetic db mice
- Principal Investigator
  
  MORITANI Maki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokushima
Identification of type 2 diabetes mellitus susceptibility candidate genes in loci detected by QTL analysis of diabetic db mice,
- Principal Investigator
  
  ITAKURA Mitsuo
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  The University of Tokushima
Wolfram症候群における神経細胞・膵β細胞の"選択的な死"の機構の解明Principal Investigator
- Principal Investigator
  
  井上寛
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Yamaguchi University
Molecular approach for the mechanism of insulin-stimulated glucose transport
- Principal Investigator
  
  OKA Yoshitomo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Metabolomics
- Research Institution
  Yamaguchi University
Elucidation of molecular pathophysiology and development of the methods for molecular diagnosis of the disease associated with WFS1 gene mutations.
- Principal Investigator
  
  TANIZAWA Yukio
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Yamaguchi University
Regulation of Pacreatic β-cell Function by Transcription Factors.
- Principal Investigator
  
  TANIZAWA Yukio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Yamaguchi University
treatment using adenovirus vector
- Principal Investigator
  
  OKA Yoshitomo
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Yamaguchi University

All 2014 2013 2012 2011 2008 2007

All Journal Article Presentation

[Journal Article] TMEM16E (GDD1) exhibits protein instability and distinct characteristics in chloride channel/pore forming ability.2014
- Author(s)
  Tran TT, Tobiume K, Hirono C, Fujimoto S, Mizuta K, Kubozono K, Inoue H, Itakura M, Sugita M, Kamata N.
- Journal Title
  
  J Cell Physiol.
  
  Volume: 229(2) Issue: 2 Pages: 181-190
- DOI
  10.1002/jcp.24431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592734, KAKENHI-PROJECT-24591514, KAKENHI-PROJECT-24659826, KAKENHI-PROJECT-25463085
[Journal Article] Novel compound heterozygous mutations of the growth hormone-releasing hormone receptor gene in a case of isolated growth hormone deficiency.2013
- Author(s)
  Soneda A, Adachi M, Muroya K, Asakura Y, Takagi M, Hasegawa T, Inoue H, Itakura M
- Journal Title
  
  Growth Horm IGF Res.
  
  Volume: 23 Issue: 4 Pages: 89-97
- DOI
  10.1016/j.ghir.2013.03.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591514
[Journal Article] Identification of a novel mutation in the exon 2 splice donor site of the POU1F1/PIT-1 gene in Japanese identical twins with mild combined pituitary hormone deficiency2012
- Author(s)
  H.Inoue, T.Mukai, Y.Sakamoto, C.Kimura, T.Ogata, et al
- Journal Title
  
  Clin.Endocrinol.
  
  Volume: 76 Issue: 1 Pages: 78-87
- DOI
  10.1111/j.1365-2265.2011.04165.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22227002, KAKENHI-PROJECT-22590997, KAKENHI-PROJECT-23591499
[Journal Article] Analysis of expression and structure of the rat GH secretagogue/ghrelin receptor (Ghsr) gene : roles of epigenetic modifications in transcriptional regulation2011
- Author(s)
  H.Inoue, Y.Sakamoto, N.Kangawa, C.Kimura, T.Ogata, et al
- Journal Title
  
  Mol.Cell.Endocrinol.
  
  Volume: 345 Issue: 1-2 Pages: 1-15
- DOI
  10.1016/j.mce.2011.06.034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22227002, KAKENHI-PROJECT-23591499
[Journal Article] Identification and functional analysis of novel human growth hormone-releasing hormone receptor (GHRHR) gene mutations in Japanese subjects with short stature2011
- Author(s)
  H.Inoue, N.Kangawa, A.Kinouchi, Y.Sakamoto, T.Ogata, et al
- Journal Title
  
  Clin.Endocrinol.
  
  Volume: 74 Issue: 2 Pages: 223-233
- DOI
  10.1111/j.1365-2265.2010.03911.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22227002, KAKENHI-PROJECT-23591499
[Journal Article] Identification and functional analysis of novel human growth hormone secretagogue receptor (GHSR) gene mutations in Japanese subjects with short stature2011
- Author(s)
  H.Inoue, N.Kangawa, A.Kinouchi, Y.Sakamoto, T.Ogata, et al
- Journal Title
  
  J.Clin.Endocrinol.Metab.
  
  Volume: 96 Issue: 2 Pages: 373-378
- DOI
  10.1210/jc.2010-1570
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22227002, KAKENHI-PROJECT-22590997, KAKENHI-PROJECT-23591499
[Journal Article] Single nucleotide polymorphisms in genes encoding LKB1(STK11), TORC2(CRTC2) and AMPK alpha2-subunit(PRKAA2)and risk of type 2 diabetes2008
- Author(s)
  Keshavarz P, Inoue H, Itakura M, 他3名
- Journal Title
  
  Mol. Genet. Metab 9
  
  Pages: 200-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591080
[Journal Article] Transgenic expression of a utated cyclin-dependent kinase 4 (CDK4/R24C)in pancreatic beta-cells prevents progression of diabetes in db/dbmice2008
- Author(s)
  Miyatvaki K, Inoue H, Itakura M, 他7名
- Journal Title
  
  Diabetes, Res. Clin. Pract 82
  
  Pages: 33-41
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591080
[Journal Article] Genetic association between the PRKCH gene encoding protein kinase Cetaisozyme and rheumatoid arthritis in the Japanese population2007
- Author(s)
  Takata Y, Inoue H, Itakura M, 他11名
- Journal Title
  
  Arthritis Rheum 56
  
  Pages: 30-42
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591080
[Presentation] 日本人小児低身長症におけるGHRHR遺伝子の新規3変異の同定2011
- Author(s)
  井上寛
- Organizer
  第84回日本内分泌学会学術総会
- Place of Presentation
  神戸国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-23591499

1. ITAKURA Mitsuo (60134227)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
2. TANIZAWA Yukiko (00217142)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. MORITANI Maki (50301312)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KUNIKA Kiyoshi (30396254)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. OKA Yoshitomo (70175256)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. YAMASHITA Yukiko (40532502)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. AOKI Minoru (70304475)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KATAGIRI Hideki

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. YOSHIMOTO Katsuhiko (90201863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OYADOMARI Seiichi (90502534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. EMOTO Masahiro (50294640)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. MASUJIMA Tsutomu (10136054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MATSUBARA Atsushi (40311815)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. UEDA Kohei (50325221)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. TAKAHASHI Akira (90304047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NAKANO Masayuki (60398005)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MAWATARI Kazuaki (40352372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 棚橋俊仁 (30380067)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 寒川奈津美 (50597599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 亀井信二 (30314800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. INUKAI Kouichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. SAKAKI Terumasa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. NAKAI Kazuaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. TANAKA Keiji

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 0HTA Yasuharu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. TAKEDA Komei

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 野見山淳

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. OGATA Tsutomu

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
29. MIZUTA Kuniko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
30. 飛梅圭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
31. 鎌田伸之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

INOUE Hiroshi 井上 寛

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日本人小児低身長症の疾患関連遺伝子同定と分子機構の解明Principal Investigator

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Wolfram症候群における神経細胞・膵β細胞の"選択的な死"の機構の解明Principal Investigator

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[Journal Article] TMEM16E (GDD1) exhibits protein instability and distinct characteristics in chloride channel/pore forming ability.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel compound heterozygous mutations of the growth hormone-releasing hormone receptor gene in a case of isolated growth hormone deficiency.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of a novel mutation in the exon 2 splice donor site of the POU1F1/PIT-1 gene in Japanese identical twins with mild combined pituitary hormone deficiency2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of expression and structure of the rat GH secretagogue/ghrelin receptor (Ghsr) gene : roles of epigenetic modifications in transcriptional regulation2011

Author(s)

Journal Title

DOI

INOUE Hiroshi 井上寛