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INOUE Hiroshi  井上 寛

ORCIDConnect your ORCID iD *help
Researcher Number 20294639
External Links
Affiliation (based on the past Project Information) *help 2014: 徳島大学, 疾患プロテオゲノム研究センター, 講師
2013 – 2014: 徳島大学, 学内共同利用施設等, 講師
2011 – 2012: 徳島大学, 疾患プロテオゲノム研究センター, 学術研究員
2011: 徳島大学, 疾患ゲノム研究センター, 特任教授
2008: 徳島大学, 疾患ゲノム研究センター, 准教授 … More
2007: 徳島大学, ゲノム機能研究センター, 准教授
2004 – 2006: 徳島大学, ゲノム機能研究センター, 助教授
1997 – 2001: 山口大学, 医学部・附属病院, 助手
2000: 山口大, 医学部附属病院, 助手
1998: 山口大学, 医学部附属病院, 助手 Less
Review Section/Research Field
Principal Investigator
Pediatrics / Metabolomics
Except Principal Investigator
Metabolomics / Metabolomics / Bacteriology (including Mycology) / Pathological medical chemistry / 内分泌・代謝学 / Pediatrics / Endocrinology
Keywords
Principal Investigator
GWAS / 下垂体特異的転写因子Pit-1 / GH放出ホルモン受容体遺伝子 / グレリン受容体遺伝子 / 遺伝子変異 / 低身長症
Except Principal Investigator
QTL / インスリン / 糖尿病 / 疾患感受性遺伝子 … More / 2型糖尿病 / small RNA / fat pad weight / animal model of diabetes / susceptibility gene / congenic mice / 内臓脂肪量 / 動物モデル / コンジェニックマウス / Lepr^<db>マウス / PDK1 / Akt1 / GLUT4 / 遺伝子 / 難聴 / HNF-1α / 小胞体 / 視神経萎縮 / Wolfram症候群 / persistent hyperinsulinemic hypoglycemia of infancy / Wolfram syndrome / glucose transport / insulin / diabetes mellitus / インスリン分泌 / 新生児低血糖症 / PI3キナーゼ / 糖輸送 / アデノウイルスベクター / 遺伝子変異 / ERストレス / feeding volume / type 2 diabetes / Lepr^<db> mice / 内蔵脂肪量 / 高脂肪食負荷 / 節餌量 / 糖尿病動物モデル / virulence factor / post transcriptional regulation / translation / Vibrio parahaemolyticus / 病原因子 / 翻訳後調節 / 翻訳 / 腸炎ビブリオ / congenic sub-line / type 2 diabetes mellitus / Lep^<db> mice / 修飾遺伝子 / サブコンジェニックマウス / Optic Atrophy / ER stress / Mutation / Endoplasmic Reticulum / Diabetes Mellitus / Wolfram Syndrome / in situ hybridization / PI3 kinase / Insulin / PH domain / Akt / endoplasmic reticulum / PAX-4 / optic atrophy / MODY / 転写因子 / Wolframの症候群 / Pax4 / sulfonylurea receptor / PI3-kinase / adenovirus vector / ウイルスベクター / アデノウイルス / グリセロリン酸シャトル / GKラット / 遺伝子治療 / hepatocyte nuclear factor / 遺伝子導入 / 膵β細胞 / ウオルフラム症候群 / スルフォニル尿素受容体 / GH放出ホルモン受容体遺伝子 / グレリン受容体遺伝子 / 低身長症 / 細胞内局在 / 遺伝子導入法 / 遺伝子発現量 / ENDOG遺伝子 / アポトーシス / ポリクローナル抗体 / 遣伝子発現量 / ミトコンドリア / ENDOGL1遺伝子 / 疾患感受性候補遺伝子 Less
  • Research Projects

    (11 results)
  • Research Products

    (10 results)
  • Co-Researchers

    (31 People)
  •  Genetic identification and functional analysis in Japanese families with a short stature

    • Principal Investigator
      ITAKURA Mitsuo
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The University of Tokushima
  •  日本人小児低身長症の疾患関連遺伝子同定と分子機構の解明Principal Investigator

    • Principal Investigator
      井上 寛
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      The University of Tokushima
  •  Functional analysis of theENDOGL1 gene as a candidate disease susceptibility gene for T2D by rentivirus vector

    • Principal Investigator
      ITAKURA Mitsuo
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Endocrinology
    • Research Institution
      The University of Tokushima
  •  Regulatory mechanisms of production of virulence factor in Vibrio parahaemolyticus

    • Principal Investigator
      TAKAHASHI Akira
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      The University of Tokushima
  •  Mapping of susceptibility genes to diabetes by high fat diet following QTL analysis of diabetic db mice

    • Principal Investigator
      MORITANI Maki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      The University of Tokushima
  •  Identification of type 2 diabetes mellitus susceptibility candidate genes in loci detected by QTL analysis of diabetic db mice,

    • Principal Investigator
      ITAKURA Mitsuo
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      The University of Tokushima
  •  Wolfram症候群における神経細胞・膵β細胞の"選択的な死"の機構の解明Principal Investigator

    • Principal Investigator
      井上 寛
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Yamaguchi University
  •  Molecular approach for the mechanism of insulin-stimulated glucose transport

    • Principal Investigator
      OKA Yoshitomo
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Metabolomics
    • Research Institution
      Yamaguchi University
  •  Elucidation of molecular pathophysiology and development of the methods for molecular diagnosis of the disease associated with WFS1 gene mutations.

    • Principal Investigator
      TANIZAWA Yukio
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Yamaguchi University
  •  Regulation of Pacreatic β-cell Function by Transcription Factors.

    • Principal Investigator
      TANIZAWA Yukio
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Yamaguchi University
  •  treatment using adenovirus vector

    • Principal Investigator
      OKA Yoshitomo
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Yamaguchi University

All 2014 2013 2012 2011 2008 2007

All Journal Article Presentation

  • [Journal Article] TMEM16E (GDD1) exhibits protein instability and distinct characteristics in chloride channel/pore forming ability.2014

    • Author(s)
      Tran TT, Tobiume K, Hirono C, Fujimoto S, Mizuta K, Kubozono K, Inoue H, Itakura M, Sugita M, Kamata N.
    • Journal Title

      J Cell Physiol.

      Volume: 229(2) Issue: 2 Pages: 181-190

    • DOI

      10.1002/jcp.24431

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592734, KAKENHI-PROJECT-24591514, KAKENHI-PROJECT-24659826, KAKENHI-PROJECT-25463085
  • [Journal Article] Novel compound heterozygous mutations of the growth hormone-releasing hormone receptor gene in a case of isolated growth hormone deficiency.2013

    • Author(s)
      Soneda A, Adachi M, Muroya K, Asakura Y, Takagi M, Hasegawa T, Inoue H, Itakura M
    • Journal Title

      Growth Horm IGF Res.

      Volume: 23 Issue: 4 Pages: 89-97

    • DOI

      10.1016/j.ghir.2013.03.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591514
  • [Journal Article] Identification of a novel mutation in the exon 2 splice donor site of the POU1F1/PIT-1 gene in Japanese identical twins with mild combined pituitary hormone deficiency2012

    • Author(s)
      H.Inoue, T.Mukai, Y.Sakamoto, C.Kimura, T.Ogata, et al
    • Journal Title

      Clin.Endocrinol.

      Volume: 76 Issue: 1 Pages: 78-87

    • DOI

      10.1111/j.1365-2265.2011.04165.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22227002, KAKENHI-PROJECT-22590997, KAKENHI-PROJECT-23591499
  • [Journal Article] Analysis of expression and structure of the rat GH secretagogue/ghrelin receptor (Ghsr) gene : roles of epigenetic modifications in transcriptional regulation2011

    • Author(s)
      H.Inoue, Y.Sakamoto, N.Kangawa, C.Kimura, T.Ogata, et al
    • Journal Title

      Mol.Cell.Endocrinol.

      Volume: 345 Issue: 1-2 Pages: 1-15

    • DOI

      10.1016/j.mce.2011.06.034

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22227002, KAKENHI-PROJECT-23591499
  • [Journal Article] Identification and functional analysis of novel human growth hormone-releasing hormone receptor (GHRHR) gene mutations in Japanese subjects with short stature2011

    • Author(s)
      H.Inoue, N.Kangawa, A.Kinouchi, Y.Sakamoto, T.Ogata, et al
    • Journal Title

      Clin.Endocrinol.

      Volume: 74 Issue: 2 Pages: 223-233

    • DOI

      10.1111/j.1365-2265.2010.03911.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22227002, KAKENHI-PROJECT-23591499
  • [Journal Article] Identification and functional analysis of novel human growth hormone secretagogue receptor (GHSR) gene mutations in Japanese subjects with short stature2011

    • Author(s)
      H.Inoue, N.Kangawa, A.Kinouchi, Y.Sakamoto, T.Ogata, et al
    • Journal Title

      J.Clin.Endocrinol.Metab.

      Volume: 96 Issue: 2 Pages: 373-378

    • DOI

      10.1210/jc.2010-1570

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22227002, KAKENHI-PROJECT-22590997, KAKENHI-PROJECT-23591499
  • [Journal Article] Single nucleotide polymorphisms in genes encoding LKB1(STK11), TORC2(CRTC2) and AMPK alpha2-subunit(PRKAA2)and risk of type 2 diabetes2008

    • Author(s)
      Keshavarz P, Inoue H, Itakura M, 他3名
    • Journal Title

      Mol. Genet. Metab 9

      Pages: 200-209

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591080
  • [Journal Article] Transgenic expression of a utated cyclin-dependent kinase 4 (CDK4/R24C)in pancreatic beta-cells prevents progression of diabetes in db/dbmice2008

    • Author(s)
      Miyatvaki K, Inoue H, Itakura M, 他7名
    • Journal Title

      Diabetes, Res. Clin. Pract 82

      Pages: 33-41

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591080
  • [Journal Article] Genetic association between the PRKCH gene encoding protein kinase Cetaisozyme and rheumatoid arthritis in the Japanese population2007

    • Author(s)
      Takata Y, Inoue H, Itakura M, 他11名
    • Journal Title

      Arthritis Rheum 56

      Pages: 30-42

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591080
  • [Presentation] 日本人小児低身長症におけるGHRHR遺伝子の新規3変異の同定2011

    • Author(s)
      井上寛
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Data Source
      KAKENHI-PROJECT-23591499
  • 1.  ITAKURA Mitsuo (60134227)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 4 results
  • 2.  TANIZAWA Yukiko (00217142)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 3.  MORITANI Maki (50301312)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  KUNIKA Kiyoshi (30396254)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  OKA Yoshitomo (70175256)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  YAMASHITA Yukiko (40532502)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  AOKI Minoru (70304475)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  KATAGIRI Hideki
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  YOSHIMOTO Katsuhiko (90201863)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  OYADOMARI Seiichi (90502534)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  EMOTO Masahiro (50294640)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  MASUJIMA Tsutomu (10136054)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  MATSUBARA Atsushi (40311815)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  UEDA Kohei (50325221)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  TAKAHASHI Akira (90304047)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  NAKANO Masayuki (60398005)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  MAWATARI Kazuaki (40352372)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  棚橋 俊仁 (30380067)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  寒川 奈津美 (50597599)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  亀井 信二 (30314800)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  INUKAI Kouichi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  SAKAKI Terumasa
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  NAKAI Kazuaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  TANAKA Keiji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  0HTA Yasuharu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  TAKEDA Komei
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  野見山 淳
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  OGATA Tsutomu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 29.  MIZUTA Kuniko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  飛梅 圭
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  鎌田 伸之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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