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Higuchi Hajime  樋口 肇

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HAJIME Higuchi  樋口 肇

HIGUCHI Hajime  樋口 肇

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Researcher Number 20306682
Other IDs
Affiliation (Current) 2025: 国際医療福祉大学, 医学部, 主任教授
Affiliation (based on the past Project Information) *help 2018 – 2023: 国際医療福祉大学, 医学部, 主任教授
2012 – 2014: 慶應義塾大学, 医学部, 講師
2007 – 2010: Keio University, School of Medicine, Instructor
2007: Keio University, School of Medicine, Assistant Professor
2004 – 2006: 慶應義塾大学, 医学部, 助手
Review Section/Research Field
Principal Investigator
Gastroenterology / Basic Section 53010:Gastroenterology-related
Except Principal Investigator
Gastroenterology
Keywords
Principal Investigator
膵癌 / apoptosis / cancer stem cell / interferon / caspase / Death Receptor / TRAIL / cyclooxygenase-2 / hepatocellular carcinoma / side population … More / アポトーシス / 癌幹細胞 / マイクロダイセクション / 多領域シーケンス / ゲノムシーケンス / EUS-FNA / ゲノム医療 / クリニカルシーケンス / EUS-TA / オルガノイド / epithelial to mesenchymal transition / invation / EGFシグナル / interfreon / 三次元培養 / 膵臓学 / 胆道学 / 3次元培養 / 膵癌幹細胞 / 間葉系幹細胞 / CD44 / 上皮間葉転換 / FMT / Spheroid / EMT / mesenchymal stem cell / epithelial-to-mesenchymal transition … More
Except Principal Investigator
siRNA / Mcl-1 / side population / アポトーシス Less
  • Research Projects

    (6 results)
  • Research Products

    (27 results)
  • Co-Researchers

    (5 People)
  •  Utilization of organoid culture system for pancreatic cancer genome analysisPrincipal Investigator

    • Principal Investigator
      Higuchi Hajime
    • Project Period (FY)
      2018 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      International University of Health and Welfare
  •  Investigation of primary culture system for pancreatic cancer stem cellsPrincipal Investigator

    • Principal Investigator
      HAJIME Higuchi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Analysis of biological characteristic features in cancer stem cell in digestive organsPrincipal Investigator

    • Principal Investigator
      HIGUCHI Hajime
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Analysis of mechanisms of apoptosis resistance in pancreatic cancer cellsPrincipal Investigator

    • Principal Investigator
      HIGUCHI Hajime
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Identification of apoptosis sensitivity regulating molecules in gastrointestinal cancer cells

    • Principal Investigator
      TAKAISHI Hiromasa
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University
  •  Identification of Interferon Responsive Apoptosis Regulating Genes in Hepatocellular CarcinomaPrincipal Investigator

    • Principal Investigator
      HIGUCHI Hajime
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Keio University

All 2023 2022 2021 2019 2013 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

  • [Journal Article] オルガノイド培養系と膵癌個別化治療への応用2019

    • Author(s)
      樋口 肇
    • Journal Title

      BIO Clinica

      Volume: 34 Pages: 85-88

    • Data Source
      KAKENHI-PROJECT-18K07918
  • [Journal Article] Mesenchymal Stem Cells Regulate Epithelial-to-Mesenchymal Transition and Tumor Progression of Pancreatic Cancer Cells.2013

    • Author(s)
      Kabashima-Niibe A, Higuchi H, Takaishi H, Masugi Y, Matsuzaki Y, Mabuchi Y, Funakoshi S, Adachi M, Hamamoto Y, Kawachi S, Aiura K, Kitagawa Y, Sakamono M, Hibi T.
    • Journal Title

      Cancer Sci.

      Volume: 104(2) Pages: 157-164

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591017
  • [Journal Article]2010

    • Author(s)
      Satoshi Kurita, Hajime Higuchi, Yoshimasa Saito, Nobuhiro Nakamoto, Hiromasa Takaishi, Shinichiro Tada, Hidetsugu Saito, Gregory J. Gores, Toshifumi Hibi
    • Journal Title

      Cancer Sci 101

      Pages: 1431-1439

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590809
  • [Journal Article] Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion.2009

    • Author(s)
      Kabashima A, Higuchi H, Takaishi H, Matsuzaki Y, Suzuki S, Tzumiya M, Sakai G, Hozawa S, Azuma T, Hibi T
    • Journal Title

      Tnt J Cancer 124

      Pages: 2771-2779

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590809
  • [Journal Article] Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion.2009

    • Author(s)
      Ayano Kabashima, Hajime Higuchi, Hiromasa Takaishi, Yumi Matsuzaki, Sadafumi Suzuki, Motoko Izumiya, Hideko Iizuka, Gen Sakai, Shigenari Hozawa, Toshifumi Azuma, Toshifumi Hibi
    • Journal Title

      Int-J-Cancer 124

      Pages: 2771-2779

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590809
  • [Journal Article] Cyclooxygenase (COX)-2 inhibitor and interferon-beta synergistically induce apoptosis in human hepatoma cells in vitro and in vivo2006

    • Author(s)
      Nobuhiro Nakamoto, Hajime Higuchi, Hideaki Kanamori, Hitomi Horikawa, Satoshi Kurita, Tetsuya Masuda, Shinichiro Tada, Hiromasa Takaishi, Kyoko Toda, Takaya Yamada, Naoki Kumagai, Hidetsugu Saito, Toshifumi Hibi
    • Journal Title

      Int-J-Cancer (印刷中)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590632
  • [Journal Article] Cyclooxygenase (COX)-2 inhibitor and interferon-beta synergistically induce apoptosis in human hepatoma cells in vitro and in vivo2006

    • Author(s)
      Nobuhiro Nakamoto, Hajime Higuchi, Hideaki Kanamori, Hitomi Horikawa, Satoshi Kurita, Tetsuya Masuda, Shinichiro Tada, Hiromasa Takaishi, Kyoko Toda, Takaya Yamada, Naoki Kumagai, Hidetsugu Saito, Toshifumi Hibi
    • Journal Title

      Int J Cancer (In Press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590632
  • [Journal Article] Cyclooxygenase (COX)-2 inhibitor and interferon-beta synergistically induce apoptosis in human hepatoma cells in vitro and in vivo

    • Author(s)
      Nobuhiro Nakamoto, Hajime Higuchi, Hideaki Kanamori, Hitomi Horikawa, Satoshi Kurita, Tetsuya Masuda, Shinichiro Tada, Tiromasa Takaishi, Kyoko Toda, Takaya Yamada, Naoki Kumagai, Hidetsugu Saito, Toshifumi Hibi
    • Journal Title

      Int-J-Cancer (投稿中)(印刷中)

    • Data Source
      KAKENHI-PROJECT-16590632
  • [Presentation] AYA世代のがん患者の緩和ケア介入の現状と課題2023

    • Author(s)
      三浦 美和子, 星野 奈月, 船越 信介, 星野 晴彦, 樋口 肇
    • Organizer
      第28回日本緩和医療学会
    • Data Source
      KAKENHI-PROJECT-18K07918
  • [Presentation] 胃癌腹膜播種病変による通過障害に対する外科的介入の意義についての検討2023

    • Author(s)
      島田 理子, 平野祐樹, 大山 隆史, 張 舜凱, 田村 卓也, 皆川 卓也, 石田 隆, 鶴田 雅士, 星本 相淳, 篠田 昌宏, 樋口 肇, 板野 理
    • Organizer
      第95回日本胃癌学会総会
    • Data Source
      KAKENHI-PROJECT-18K07918
  • [Presentation] 便秘を契機に発見されたirAE腸炎の一例2023

    • Author(s)
      菅原 ゆたか, 小林 桃子, 山下 健太郎, 島田 理子, 大山 隆史, 小無田 美菜, 森 一郎, 林 雄一郎, 海老沼 浩利, 板野 理, 樋口 肇
    • Organizer
      第377回日本消化器by府尾学会関東支部例会
    • Data Source
      KAKENHI-PROJECT-18K07918
  • [Presentation] Genetic abnormalities and aberrant expression of genes involved in chromosome segregation and mitosis in patients with chromosomally unstable malignant soft tissue tumors haboring extensive somatic loss-of-heterozygosity (LOH).2022

    • Author(s)
      Katsuhito Takahashi, Yasutomo Miyaji, Hajime Higuchi, Yoshihiro Komohara, Jun Yashima, Hiromasa Yamamoto, Ken Suzawa, Yuko Takahashi, Shinichi Toyooka, Hiroyuki Narahara, Junko Yotsumoto, Yu Oyama, Yasuo Ono, Satoshi Teraoka, Shinsuke Aida
    • Organizer
      American Society of Clinical Oncology (ASCO) 2022 annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07918
  • [Presentation] Gemcitabine plus nab-paclitaxel versus gemcitabine alone in elderly patients aged 76 years or older with unresectable pancreatic cancer: A propensity score-matched multicenter prospective observational study.2021

    • Author(s)
      1.Satoshi Kobayashi, Motoko Suzuki ,Makoto Ueno, Yuta Maruki ,Junji Furuse, Akiko Todaka, Masato Ozaka, Kunihiro Tsuji, Kazuhiko Shioji, Keitaro Doi, Yasushi Kojima, Hidetaka Tsumura, Kazunari Tanaka, Hajime Higuchi, Ken Kawabe, Takeharu Yamanaka, Hiroshi Ishii.
    • Organizer
      American Society of Clinical Oncology (ASCO) 2021 annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07918
  • [Presentation] Mesenchymal stem cells mediate epithelial-to-mesenchymal transition (EMT)2013

    • Author(s)
      A. Kabashima-Niibe, H. Higuchi, Y. Matsuzaki, et. al.
    • Organizer
      American Association for Cancer Research 104th Annual Meeting,
    • Place of Presentation
      Washington D.C
    • Data Source
      KAKENHI-PROJECT-24591017
  • [Presentation] Mesenchymal stem cells induce epithelial-to-mesenchymal transition (EMT) in metastatic SP cells in pancreatic cancer.2010

    • Author(s)
      Ayano Kabashima, Hajime Higuchi, Yumi Matsuzaki, Shinsuke Funakoshi, Masayuki Adachi, Motoko Izumiya, Gen Sakai, Toru Igarashi, Shoko Nakamura, Hiromasa Takaishi, Toshifumi Hibi
    • Organizer
      AACR meeting abstract 2010, 387 101st American Association for Cancer Research
    • Place of Presentation
      Washington
    • Data Source
      KAKENHI-PROJECT-20590809
  • [Presentation] Wnt signaling contributes to the maintenance of cancer stem cell-like populations in Huh7 hepatocellular carcinoma cell line : Role of hepatic stellate cells.2010

    • Author(s)
      Masayuki Adachi, Hajime Higuchi, Ayano Kabashima, Shinsuke Funakoshi, Shoko Nakamura, Hiromasa Takaishi, Toshifumi Hibi
    • Organizer
      AACR meeting abstract 2010, 203
    • Place of Presentation
      Washington
    • Data Source
      KAKENHI-PROJECT-20590809
  • [Presentation] Cancer stem cell like properties of 5-fluorouracil resistant Panc2010

    • Author(s)
      Motoko Izumiya, Hajime Higuchi, Ayano Kabashima, Toru Igarashi, Shoko Nakamura, Shinsuke Funakoshi, Masayuki Adachi, Hiromasa Takaishi, Toshifumi Hibi
    • Organizer
      AACR meeting abstract 2010, 335 101^<st> American Association for Cancer Research
    • Place of Presentation
      Washington
    • Data Source
      KAKENHI-PROJECT-20590809
  • [Presentation] Isolation and identification of Notch signal positive cells in pancreatic cancer cell line.2009

    • Author(s)
      Gen Sakai, Hajime Higuchi, Hiromasa Takaishi, Motoko Izumiya, Masaya Adachi, Ayano Kabashima, Shouko Nakamura, Toshifumi Hibi
    • Organizer
      AACR meeting abstract 2009, 193 100^<th> American Association for Cancer Research.
    • Place of Presentation
      Denver
    • Data Source
      KAKENHI-PROJECT-20590809
  • [Presentation] ヒト膵癌細胞株由来side population細胞はTGF-betaによる浸潤・FMTへ高井反応性を持つ.2008

    • Author(s)
      樺嶋彩乃, 樋口肇, 松崎有未, 泉谷幹子, 飯塚秀子, 酒井元, 高石官均, 日比紀文
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Data Source
      KAKENHI-PROJECT-20590809
  • [Presentation] Transforming growth factor(TGF)-bate induces pancreatic cancer cell invasion and epithelial to mesenchymal(EMT)in side-population(SP)cells but not in non SP cells2007

    • Author(s)
      Kabashima A, Higuchi H, Matsuzaki Y, Hasegawa G, Kuriyama N, Takaishi H, Izumiya M, Iizuka H, Sakai G, and Hibi T.
    • Organizer
      2007 AACR Annual Meeting
    • Place of Presentation
      Los Angeles,CA
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590747
  • [Presentation] Transforming growth factor(TGF)-bate induces pancreatic cancer cell invasion and epithelial to mesenchymal (EMT)in side-population(SP)cells but not in non SP cells.2007

    • Author(s)
      Kabashima, A., Higuchi, H., Matsuzaki, Y., Hasegawa, G., Kuriyama, N., Takaishi, H., Izumiya, M., Iizuka, H., Sakai, G., Hibi, T
    • Organizer
      2007 AACR Annual Meeting
    • Place of Presentation
      Los Angeles, CA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590745
  • [Presentation] Mcl-1 depletion sensitizes the apoptosis of gastrointestinal cancer cells mediated by anti-cancer drugs2007

    • Author(s)
      Iizuka H, Higuchi H, Suminmoto H, Kabashima A, Kuriy ama N, Sakai G, Izumiya M, Ymagishi Y, Takaishi H, Kawakami Y, Mizoeuchi H. and Hibi T.
    • Organizer
      2007 AACR Annual Meeting
    • Place of Presentation
      Los Angeles,CA
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590745
  • [Presentation] Transforming growth factor(TGF)-bate induces pancreatic cancer cell invasion and epithelial to mesenchymal(EMT)in side-population(SP)cells but not in non SP cells2007

    • Author(s)
      Kabashima A, Higuchi H, Matsuzaki Y, Hasegawa G, Kuriyama N, Takaishi H, Izumiya M, izuka H, Sakai G, and Hibi T.
    • Organizer
      2007 AACR Annual Meeting
    • Place of Presentation
      Los Angeles,CA
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590745
  • [Presentation] Mcl-1 depletion sensitizes the apoptosis of gastrointestinal cancer cells mediated by anti-cancer drugs2007

    • Author(s)
      Iizuka H, Higuchi H, Sumimoto H, Kabashima A, Kuriyama N, Sakai G, Izumiya M, Ymagishi Y, Takaishi H, Kawakami Y, Mizoguchi H, and Hibi T.
    • Organizer
      2007 AACR Annual Meeting
    • Place of Presentation
      Los Angeles,CA
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590747
  • [Presentation] Transforming growth factor (TGF)-bate induces pancreatic cancer cell invasion and epithelial to mesenchymal (EMT) in side-population (SP) cells but not in non SP cells.2007

    • Author(s)
      Kabashima, A., Higuchi, H., Matsuzaki, Y., Hasegawa, G., Kuriyama, N., Takaishi, H., Izumiya, M., Iizuka, H., Sakai, G., Hibi, T
    • Organizer
      2007 AACR Annual Meeting
    • Place of Presentation
      Los Angeles, CA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590747
  • [Presentation] Mcl-l depletion sensitizes the apoptosis of gastrointestinal cancer cells mediated by anti-cancer drugs.2007

    • Author(s)
      Iizuka, H., Higuchi, H., Sumimoto, H., Kabashima, A., Kuriyama, N., Sakai, G., Izumiya M., Ymagishi, Y., Takaishi, H., Kawakami Y, Mizoguchi, H., Hibi T
    • Organizer
      2007 AACR Annual Meeting
    • Place of Presentation
      Los Angeles, CA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590745
  • [Presentation] Mcl-1 depletion sensitizes the apoptosis of gastrointestinal cancer cells mediated by anti-cancer drugs.2007

    • Author(s)
      Iizuka, H., Higuchi, H., Sumimoto, H., Kabashima, A., Kuriyama, N., Sakai, G., Izumiya, M., Ymagishi, Y., Takaishi, H., Kawakami, Y., Mizoguchi, H., Hibi, T
    • Organizer
      2007 AACR Annual Meeting
    • Place of Presentation
      Los Angeles, CA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590747
  • 1.  TAKAISHI Hiromasa (80286468)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 8 results
  • 2.  SATO Toshiro (70365245)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  IZUMIYA Motoko (70342657)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 4 results
  • 4.  高橋 克仁 (40211338)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  潮見 隆之 (80348797)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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