Higuchi Hajime 樋口肇

… Alternative Names

HAJIME Higuchi 樋口肇

HIGUCHI Hajime 樋口肇

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Researcher Number	20306682
Other IDs
Affiliation (Current)	2025: 国際医療福祉大学, 医学部, 主任教授
Affiliation (based on the past Project Information) *help	2025: 国際医療福祉大学, 医学部, 主任教授 2018 – 2023: 国際医療福祉大学, 医学部, 主任教授 2012 – 2014: 慶應義塾大学, 医学部, 講師 2007 – 2010: Keio University, School of Medicine, Instructor 2007: Keio University, School of Medicine, Assistant Professor 2004 – 2006: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 59010:Rehabilitation science-related / Gastroenterology
Keywords	Principal Investigator 膵癌 / apoptosis / cancer stem cell / interferon / caspase / Death Receptor / TRAIL / cyclooxygenase-2 / hepatocellular carcinoma / side population … More / アポトーシス / 癌幹細胞 / マイクロダイセクション / 多領域シーケンス / ゲノムシーケンス / EUS-FNA / ゲノム医療 / クリニカルシーケンス / EUS-TA / オルガノイド / epithelial to mesenchymal transition / invation / EGFシグナル / interfreon / 三次元培養 / 膵臓学 / 胆道学 / 3次元培養 / 膵癌幹細胞 / 間葉系幹細胞 / CD44 / 上皮間葉転換 / FMT / Spheroid / EMT / mesenchymal stem cell / epithelial-to-mesenchymal transition … More Except Principal Investigator siRNA / Mcl-1 / 歩行解析 / 高齢者機能評価 / 消化器がん / 高齢がん患者 / がんロコモ / side population / アポトーシス Less

高齢消化器がん患者の歩行特徴に基づいたがんロコモ予防プログラムの開発
- Principal Investigator
  
  島田理子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  International University of Health and Welfare
Utilization of organoid culture system for pancreatic cancer genome analysisPrincipal Investigator
- Principal Investigator
  
  Higuchi Hajime
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  International University of Health and Welfare
Investigation of primary culture system for pancreatic cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  HAJIME Higuchi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Analysis of biological characteristic features in cancer stem cell in digestive organsPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Hajime
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Analysis of mechanisms of apoptosis resistance in pancreatic cancer cellsPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Hajime
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Identification of apoptosis sensitivity regulating molecules in gastrointestinal cancer cells
- Principal Investigator
  
  TAKAISHI Hiromasa
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
Identification of Interferon Responsive Apoptosis Regulating Genes in Hepatocellular CarcinomaPrincipal Investigator
- Principal Investigator
  
  HIGUCHI Hajime
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University

All 2023 2022 2021 2019 2013 2010 2009 2008 2007 2006 Other

All Journal Article Presentation

[Journal Article] オルガノイド培養系と膵癌個別化治療への応用2019
- Author(s)
  樋口　肇
- Journal Title
  
  BIO Clinica
  
  Volume: 34 Pages: 85-88
- Data Source
  KAKENHI-PROJECT-18K07918
[Journal Article] Mesenchymal Stem Cells Regulate Epithelial-to-Mesenchymal Transition and Tumor Progression of Pancreatic Cancer Cells.2013
- Author(s)
  Kabashima-Niibe A, Higuchi H, Takaishi H, Masugi Y, Matsuzaki Y, Mabuchi Y, Funakoshi S, Adachi M, Hamamoto Y, Kawachi S, Aiura K, Kitagawa Y, Sakamono M, Hibi T.
- Journal Title
  
  Cancer Sci.
  
  Volume: 104(2) Pages: 157-164
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591017
[Journal Article]2010
- Author(s)
  Satoshi Kurita, Hajime Higuchi, Yoshimasa Saito, Nobuhiro Nakamoto, Hiromasa Takaishi, Shinichiro Tada, Hidetsugu Saito, Gregory J. Gores, Toshifumi Hibi
- Journal Title
  
  Cancer Sci 101
  
  Pages: 1431-1439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590809
[Journal Article] Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion.2009
- Author(s)
  Kabashima A, Higuchi H, Takaishi H, Matsuzaki Y, Suzuki S, Tzumiya M, Sakai G, Hozawa S, Azuma T, Hibi T
- Journal Title
  
  Tnt J Cancer 124
  
  Pages: 2771-2779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590809
[Journal Article] Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion.2009
- Author(s)
  Ayano Kabashima, Hajime Higuchi, Hiromasa Takaishi, Yumi Matsuzaki, Sadafumi Suzuki, Motoko Izumiya, Hideko Iizuka, Gen Sakai, Shigenari Hozawa, Toshifumi Azuma, Toshifumi Hibi
- Journal Title
  
  Int-J-Cancer 124
  
  Pages: 2771-2779
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590809
[Journal Article] Cyclooxygenase (COX)-2 inhibitor and interferon-beta synergistically induce apoptosis in human hepatoma cells in vitro and in vivo2006
- Author(s)
  Nobuhiro Nakamoto, Hajime Higuchi, Hideaki Kanamori, Hitomi Horikawa, Satoshi Kurita, Tetsuya Masuda, Shinichiro Tada, Hiromasa Takaishi, Kyoko Toda, Takaya Yamada, Naoki Kumagai, Hidetsugu Saito, Toshifumi Hibi
- Journal Title
  
  Int-J-Cancer (印刷中)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16590632
[Journal Article] Cyclooxygenase (COX)-2 inhibitor and interferon-beta synergistically induce apoptosis in human hepatoma cells in vitro and in vivo2006
- Author(s)
  Nobuhiro Nakamoto, Hajime Higuchi, Hideaki Kanamori, Hitomi Horikawa, Satoshi Kurita, Tetsuya Masuda, Shinichiro Tada, Hiromasa Takaishi, Kyoko Toda, Takaya Yamada, Naoki Kumagai, Hidetsugu Saito, Toshifumi Hibi
- Journal Title
  
  Int J Cancer (In Press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590632
[Journal Article] Cyclooxygenase (COX)-2 inhibitor and interferon-beta synergistically induce apoptosis in human hepatoma cells in vitro and in vivo
- Author(s)
  Nobuhiro Nakamoto, Hajime Higuchi, Hideaki Kanamori, Hitomi Horikawa, Satoshi Kurita, Tetsuya Masuda, Shinichiro Tada, Tiromasa Takaishi, Kyoko Toda, Takaya Yamada, Naoki Kumagai, Hidetsugu Saito, Toshifumi Hibi
- Journal Title
  
  Int-J-Cancer (投稿中)(印刷中)
- Data Source
  KAKENHI-PROJECT-16590632
[Presentation] AYA世代のがん患者の緩和ケア介入の現状と課題2023
- Author(s)
  三浦美和子, 星野奈月, 船越信介, 星野晴彦, 樋口肇
- Organizer
  第28回日本緩和医療学会
- Data Source
  KAKENHI-PROJECT-18K07918
[Presentation] 胃癌腹膜播種病変による通過障害に対する外科的介入の意義についての検討2023
- Author(s)
  島田理子, 平野祐樹, 大山隆史, 張舜凱, 田村卓也, 皆川卓也, 石田隆, 鶴田雅士, 星本相淳, 篠田昌宏, 樋口肇, 板野理
- Organizer
  第95回日本胃癌学会総会
- Data Source
  KAKENHI-PROJECT-18K07918
[Presentation] 便秘を契機に発見されたirAE腸炎の一例2023
- Author(s)
  菅原ゆたか, 小林桃子, 山下健太郎, 島田理子, 大山隆史, 小無田美菜, 森一郎, 林雄一郎, 海老沼浩利, 板野理, 樋口肇
- Organizer
  第377回日本消化器ｂｙ府尾学会関東支部例会
- Data Source
  KAKENHI-PROJECT-18K07918
[Presentation] Genetic abnormalities and aberrant expression of genes involved in chromosome segregation and mitosis in patients with chromosomally unstable malignant soft tissue tumors haboring extensive somatic loss-of-heterozygosity (LOH).2022
- Author(s)
  Katsuhito Takahashi, Yasutomo Miyaji, Hajime Higuchi, Yoshihiro Komohara, Jun Yashima, Hiromasa Yamamoto, Ken Suzawa, Yuko Takahashi, Shinichi Toyooka, Hiroyuki Narahara, Junko Yotsumoto, Yu Oyama, Yasuo Ono, Satoshi Teraoka, Shinsuke Aida
- Organizer
  American Society of Clinical Oncology (ASCO) 2022 annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07918
[Presentation] Gemcitabine plus nab-paclitaxel versus gemcitabine alone in elderly patients aged 76 years or older with unresectable pancreatic cancer: A propensity score-matched multicenter prospective observational study.2021
- Author(s)
  1.Satoshi Kobayashi, Motoko Suzuki ,Makoto Ueno, Yuta Maruki ,Junji Furuse, Akiko Todaka, Masato Ozaka, Kunihiro Tsuji, Kazuhiko Shioji, Keitaro Doi, Yasushi Kojima, Hidetaka Tsumura, Kazunari Tanaka, Hajime Higuchi, Ken Kawabe, Takeharu Yamanaka, Hiroshi Ishii.
- Organizer
  American Society of Clinical Oncology (ASCO) 2021 annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07918
[Presentation] Mesenchymal stem cells mediate epithelial-to-mesenchymal transition (EMT)2013
- Author(s)
  A. Kabashima-Niibe, H. Higuchi, Y. Matsuzaki, et. al.
- Organizer
  American Association for Cancer Research 104th Annual Meeting,
- Place of Presentation
  Washington D.C
- Data Source
  KAKENHI-PROJECT-24591017
[Presentation] Mesenchymal stem cells induce epithelial-to-mesenchymal transition (EMT) in metastatic SP cells in pancreatic cancer.2010
- Author(s)
  Ayano Kabashima, Hajime Higuchi, Yumi Matsuzaki, Shinsuke Funakoshi, Masayuki Adachi, Motoko Izumiya, Gen Sakai, Toru Igarashi, Shoko Nakamura, Hiromasa Takaishi, Toshifumi Hibi
- Organizer
  AACR meeting abstract 2010, 387 101st American Association for Cancer Research
- Place of Presentation
  Washington
- Data Source
  KAKENHI-PROJECT-20590809
[Presentation] Wnt signaling contributes to the maintenance of cancer stem cell-like populations in Huh7 hepatocellular carcinoma cell line : Role of hepatic stellate cells.2010
- Author(s)
  Masayuki Adachi, Hajime Higuchi, Ayano Kabashima, Shinsuke Funakoshi, Shoko Nakamura, Hiromasa Takaishi, Toshifumi Hibi
- Organizer
  AACR meeting abstract 2010, 203
- Place of Presentation
  Washington
- Data Source
  KAKENHI-PROJECT-20590809
[Presentation] Cancer stem cell like properties of 5-fluorouracil resistant Panc2010
- Author(s)
  Motoko Izumiya, Hajime Higuchi, Ayano Kabashima, Toru Igarashi, Shoko Nakamura, Shinsuke Funakoshi, Masayuki Adachi, Hiromasa Takaishi, Toshifumi Hibi
- Organizer
  AACR meeting abstract 2010, 335 101^<st> American Association for Cancer Research
- Place of Presentation
  Washington
- Data Source
  KAKENHI-PROJECT-20590809
[Presentation] Isolation and identification of Notch signal positive cells in pancreatic cancer cell line.2009
- Author(s)
  Gen Sakai, Hajime Higuchi, Hiromasa Takaishi, Motoko Izumiya, Masaya Adachi, Ayano Kabashima, Shouko Nakamura, Toshifumi Hibi
- Organizer
  AACR meeting abstract 2009, 193 100^<th> American Association for Cancer Research.
- Place of Presentation
  Denver
- Data Source
  KAKENHI-PROJECT-20590809
[Presentation] ヒト膵癌細胞株由来side population細胞はTGF-betaによる浸潤・FMTへ高井反応性を持つ.2008
- Author(s)
  樺嶋彩乃, 樋口肇, 松崎有未, 泉谷幹子, 飯塚秀子, 酒井元, 高石官均, 日比紀文
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20590809
[Presentation] Transforming growth factor(TGF)-bate induces pancreatic cancer cell invasion and epithelial to mesenchymal(EMT)in side-population(SP)cells but not in non SP cells2007
- Author(s)
  Kabashima A, Higuchi H, Matsuzaki Y, Hasegawa G, Kuriyama N, Takaishi H, Izumiya M, Iizuka H, Sakai G, and Hibi T.
- Organizer
  2007 AACR Annual Meeting
- Place of Presentation
  Los Angeles,CA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590747
[Presentation] Transforming growth factor(TGF)-bate induces pancreatic cancer cell invasion and epithelial to mesenchymal (EMT)in side-population(SP)cells but not in non SP cells.2007
- Author(s)
  Kabashima, A., Higuchi, H., Matsuzaki, Y., Hasegawa, G., Kuriyama, N., Takaishi, H., Izumiya, M., Iizuka, H., Sakai, G., Hibi, T
- Organizer
  2007 AACR Annual Meeting
- Place of Presentation
  Los Angeles, CA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590745
[Presentation] Mcl-1 depletion sensitizes the apoptosis of gastrointestinal cancer cells mediated by anti-cancer drugs2007
- Author(s)
  Iizuka H, Higuchi H, Suminmoto H, Kabashima A, Kuriy ama N, Sakai G, Izumiya M, Ymagishi Y, Takaishi H, Kawakami Y, Mizoeuchi H. and Hibi T.
- Organizer
  2007 AACR Annual Meeting
- Place of Presentation
  Los Angeles,CA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590745
[Presentation] Transforming growth factor(TGF)-bate induces pancreatic cancer cell invasion and epithelial to mesenchymal(EMT)in side-population(SP)cells but not in non SP cells2007
- Author(s)
  Kabashima A, Higuchi H, Matsuzaki Y, Hasegawa G, Kuriyama N, Takaishi H, Izumiya M, izuka H, Sakai G, and Hibi T.
- Organizer
  2007 AACR Annual Meeting
- Place of Presentation
  Los Angeles,CA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590745
[Presentation] Mcl-1 depletion sensitizes the apoptosis of gastrointestinal cancer cells mediated by anti-cancer drugs2007
- Author(s)
  Iizuka H, Higuchi H, Sumimoto H, Kabashima A, Kuriyama N, Sakai G, Izumiya M, Ymagishi Y, Takaishi H, Kawakami Y, Mizoguchi H, and Hibi T.
- Organizer
  2007 AACR Annual Meeting
- Place of Presentation
  Los Angeles,CA
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590747
[Presentation] Transforming growth factor (TGF)-bate induces pancreatic cancer cell invasion and epithelial to mesenchymal (EMT) in side-population (SP) cells but not in non SP cells.2007
- Author(s)
  Kabashima, A., Higuchi, H., Matsuzaki, Y., Hasegawa, G., Kuriyama, N., Takaishi, H., Izumiya, M., Iizuka, H., Sakai, G., Hibi, T
- Organizer
  2007 AACR Annual Meeting
- Place of Presentation
  Los Angeles, CA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590747
[Presentation] Mcl-l depletion sensitizes the apoptosis of gastrointestinal cancer cells mediated by anti-cancer drugs.2007
- Author(s)
  Iizuka, H., Higuchi, H., Sumimoto, H., Kabashima, A., Kuriyama, N., Sakai, G., Izumiya M., Ymagishi, Y., Takaishi, H., Kawakami Y, Mizoguchi, H., Hibi T
- Organizer
  2007 AACR Annual Meeting
- Place of Presentation
  Los Angeles, CA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590745
[Presentation] Mcl-1 depletion sensitizes the apoptosis of gastrointestinal cancer cells mediated by anti-cancer drugs.2007
- Author(s)
  Iizuka, H., Higuchi, H., Sumimoto, H., Kabashima, A., Kuriyama, N., Sakai, G., Izumiya, M., Ymagishi, Y., Takaishi, H., Kawakami, Y., Mizoguchi, H., Hibi, T
- Organizer
  2007 AACR Annual Meeting
- Place of Presentation
  Los Angeles, CA
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590747

1. TAKAISHI Hiromasa (80286468)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
2. SATO Toshiro (70365245)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. IZUMIYA Motoko (70342657)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. 高橋克仁 (40211338)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 潮見隆之 (80348797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 島田理子 (30627138)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 角田亘 (00453788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 篠田昌宏 (50286499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 板野理 (90265827)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Higuchi Hajime 樋口 肇

HAJIME Higuchi 樋口 肇

HIGUCHI Hajime 樋口 肇

Research Projects

Research Products

Co-Researchers

高齢消化器がん患者の歩行特徴に基づいたがんロコモ予防プログラムの開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Utilization of organoid culture system for pancreatic cancer genome analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of primary culture system for pancreatic cancer stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of biological characteristic features in cancer stem cell in digestive organsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of mechanisms of apoptosis resistance in pancreatic cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of apoptosis sensitivity regulating molecules in gastrointestinal cancer cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of Interferon Responsive Apoptosis Regulating Genes in Hepatocellular CarcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] オルガノイド培養系と膵癌個別化治療への応用2019

Author(s)

Journal Title

Data Source

[Journal Article] Mesenchymal Stem Cells Regulate Epithelial-to-Mesenchymal Transition and Tumor Progression of Pancreatic Cancer Cells.2013

Author(s)

Journal Title

Data Source

[Journal Article]2010

Author(s)

Journal Title

Data Source

[Journal Article] Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion.2009

Author(s)

Journal Title

Data Source

[Journal Article] Side population of pancreatic cancer cells predominates in TGF-beta-mediated epithelial to mesenchymal transition and invasion.2009

Author(s)

Journal Title

Data Source

[Journal Article] Cyclooxygenase (COX)-2 inhibitor and interferon-beta synergistically induce apoptosis in human hepatoma cells in vitro and in vivo2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Cyclooxygenase (COX)-2 inhibitor and interferon-beta synergistically induce apoptosis in human hepatoma cells in vitro and in vivo2006

Author(s)

Journal Title

Description

Data Source

[Journal Article] Cyclooxygenase (COX)-2 inhibitor and interferon-beta synergistically induce apoptosis in human hepatoma cells in vitro and in vivo

Author(s)

Higuchi Hajime 樋口肇

HAJIME Higuchi 樋口肇

HIGUCHI Hajime 樋口肇