Ohshima Toshio 大島登志男

… Alternative Names

OOSHIMA Toshio 大島登志男

大島登志雄オオシマトシオ

大島登志男オオシマトシオ

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Researcher Number	20311334
Other IDs
Affiliation (Current)	2026: 早稲田大学, 理工学術院, 教授
Affiliation (based on the past Project Information) *help	2018 – 2025: 早稲田大学, 理工学術院, 教授 2014 – 2016: 早稲田大学, 理工学術院, 教授 2008 – 2011: 早稲田大学, 理工学術院, 教授 2007: The Institute of Physical and Chemical Research, Laboratory for Developmental Neurobiology, Visiting Researcher 2007: 理化学研究所, 発生神経生物研究チーム, 副チームリーダー … More 2007: The Institute of Physical and Chemical Research, 発生神経生物研究チーム, 客員研究員 2006: 横浜市立大学, 理化学研究所・発生神経生物研究チーム, 副チームリーダー 2004 – 2006: 独立行政法人理化学研究所, 発生神経生物研究チーム, 副チームリーダー 2005: 理化学研究所, 発生神経生物研究チーム, 副チームリーダー 2003: 独立行政法人理化学研究所, 発生神経生物研究チーム, 研究員 1999 – 2000: 理化学研究所, 発生神経生物研究チーム, 研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 46020:Anatomy and histopathology of nervous system-related / Neurochemistry/Neuropharmacology / Nerve anatomy/Neuropathology / Biological Sciences / Nerve anatomy/Neuropathology Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Biological Sciences
Keywords	Principal Investigator 神経再生 / Dab1 / Cdk5 / リン酸化 / キナーゼ / CRMP / stathmin / GSK3β / 脊髄損傷 / コンディショナルKO … More / Reelin / セリン・スレオニンキナーゼ / 神経回路形成 / 神経損傷 / モデルマウス / パーキンソン病 / マウスモデル / 神経変性疾患 / MS analysis / mutant mice / 2D-DIGE / proteomics / protein phosphorvlation / 変異マウス / 質量分析 / 2次元電気泳動 / プロテオーム解析 / タンパク質リン酸化 / Alzheimer's disease / tubulin / cyclin-dependent kinase / threonine kinase / serine / phosphorylation / 細胞移動 / 大脳皮質 / アルツハイマー病 / リーリン / チュブリン / サイクリン依存性キナーゼ / 神経発達 / 神経発生 / スパイン形成 / 樹状突起形成 / 大脳皮質形成 / LTD / LTP / CaMKII / tamoxifen / Cre recombinase / マウス / mouse / neuron / migration / kinase / Pak1 / p35 / 神経特異的 … More Except Principal Investigator Th17細胞 / 甲状腺ホルモン / Eomes陽性Th細胞 / EAE / 神経・内分泌・免疫制御 / 神経・免疫・内分泌連関 / 中枢神経慢性炎症 / 神経・免疫・内分泌相関 / 内分泌性制御因子 / Eomes+ Th細胞 / プロラクチン / 環境因子 / 内分泌性免疫制御因子 / 免疫性神経疾患 / ノックアウトマウス / 軸索ガイダンス / 皮質 / 細胞移動 / Slit / Vab-8 / axonal transport / UNC-51 / Netrin / Sema3A / 軸索ガイダンス分子 / 組織構築 / 神経ガイダンス / プレキシン / セマフォリン / CRMP Less

神経炎症とCRMPの関連の解明と神経疾患治療への応用Principal Investigator
- Principal Investigator
  
  大島登志男
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Waseda University
Study on the role of CRMP2 phosphorylation in neural circuit formation and regenerationPrincipal Investigator
- Principal Investigator
  
  Ohshima Toshio
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Waseda University
Study to develop therapeutic strategy of neurodegenerative disorders by targeting on CRMPPrincipal Investigator
- Principal Investigator
  
  Ohshima Toshio
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 46020:Anatomy and histopathology of nervous system-related
- Research Institution
  Waseda University
Cross-talk between endocrine and environmental factors in neuroimmune disorders
- Principal Investigator
  
  Yamamura Takashi
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  National Center of Neurology and Psychiatry
Elucidation of roles of CRMP in neural circuit formation and regeneration and application for the treatment of spinal cord injuryPrincipal Investigator
- Principal Investigator
  
  Ohshima Toshio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Waseda University
Functional analysis of Cdk5 by using conditional KO of its activating subunit p35Principal Investigator
- Principal Investigator
  
  OHSHIMA Toshio
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Waseda University
誘導型コンディショナルKOを用いたCdk5の脳機能における役割の解明Principal Investigator
- Principal Investigator
  
  大島登志男
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The Institute of Physical and Chemical Research
Proteomics of phospho-proteins during brain development using mutant micePrincipal Investigator
- Principal Investigator
  
  OHSHIMA Toshio
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  The Institute of Physical and Chemical Research
The role of CRMP family proteins in the establishment of neural tissue architectures
- Principal Investigator
  
  GOSHIMA Yoshio
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Yokohama City University
Identification and functional analysis of Cdk5-mediated phosphorylation of the proteins that are related to brain formation and developmentPrincipal Investigator
- Principal Investigator
  
  OHSHIMA Toshio
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  RIKEN
神経特異的サイクリン依存性キナーゼ(cdk5)の個体レベルでの機能解析Principal Investigator
- Principal Investigator
  
  大島登志男
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  The Institute of Physical and Chemical Research

[Book] 神経特異的キナーゼCdk5の神経発達と神経変性への関与. Brain Science Review 20102010
- Author(s)
  大島登志男
- Publisher
  クバプロ
- Data Source
  KAKENHI-PROJECT-21500356
[Journal Article] CRMP2 and its phosphorylation prevent axonal misrouting of the corticospinal tract2025
- Author(s)
  Takizawa Satohiro、Nakanishi Yurika、Koga Yumeno、Yamazaki Yuki、Kolattukudy Papachan、Goshima Yoshio、Ohshima Toshio
- Journal Title
  
  Neuroscience Letters
  
  Volume: 855 Pages: 138231-138231
- DOI
  10.1016/j.neulet.2025.138231
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06464
[Journal Article] Inhibition of CRMP2 Phosphorylation Suppresses Microglia Activation in the Retina and Optic Nerve and Promotes Optic Nerve Regeneration After Optic Nerve Injury2024
- Author(s)
  Wang Yuebing、Harada Sayaka、Goshima Yoshio、Ohshima Toshio
- Journal Title
  
  NeuroMolecular Medicine
  
  Volume: 26 Issue: 1 Pages: 37-37
- DOI
  10.1007/s12017-024-08805-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06464
[Journal Article] Drug Treatment Attenuates Retinal Ganglion Cell Death by Inhibiting Collapsin Response Mediator Protein 2 Phosphorylation in Mouse Models of Normal Tension Glaucoma2024
- Author(s)
  Wang Yuebing、Brahma Musukha Mala、Takahashi Kazuya、Hernandez Alessandra Nolia Blanco、Ichikawa Koki、Minami Syuntaro、Goshima Yoshio、Harada Takayuki、Ohshima Toshio
- Journal Title
  
  NeuroMolecular Medicine
  
  Volume: 26 Issue: 1 Pages: 13-13
- DOI
  10.1007/s12017-024-08778-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06464, KAKENHI-PROJECT-21K18279, KAKENHI-PROJECT-21H02819
[Journal Article] Unraveling the Nexus: The Role of Collapsin Response Mediator Protein 2 Phosphorylation in Neurodegeneration and Neuroregeneration2024
- Author(s)
  Wang Yuebing、Ohshima Toshio
- Journal Title
  
  NeuroMolecular Medicine
  
  Volume: 26 Issue: 1 Pages: 45-45
- DOI
  10.1007/s12017-024-08814-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06464
[Journal Article] Genetic inhibition of collapsin response mediator protein‐2 phosphorylation ameliorates retinal ganglion cell death in normal‐tension glaucoma models2022
- Author(s)
  Brahma Musukha Mala、Takahashi Kazuya、Namekata Kazuhiko、Harada Takayuki、Goshima Yoshio、Ohshima Toshio
- Journal Title
  
  Genes to Cells
  
  Volume: 27 Issue: 8 Pages: 526-536
- DOI
  10.1111/gtc.12971
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18279, KAKENHI-PROJECT-19KK0229, KAKENHI-PROJECT-21H02819, KAKENHI-PROJECT-20K07751, KAKENHI-PROJECT-22K06464
[Journal Article] Loss of Collapsin Response Mediator Protein 4 Attenuates 6-Hydroxydopamine-Induced Impairments in a Mouse Model of Parkinson’s Disease2020
- Author(s)
  Li Wenting、Goshima Yoshio、Ohshima Toshio
- Journal Title
  
  Neurochemical Research
  
  Volume: 45 Issue: 10 Pages: 2286-2301
- DOI
  10.1007/s11064-020-03086-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06511
[Journal Article] Lanthionine ketimine ester improves outcome in an MPTP-induced mouse model of Parkinson's disease via suppressions of CRMP2 phosphorylation and microglial activation2020
- Author(s)
  Togashi Kentaro、Hasegawa Masaya、Nagai Jun、Kotaka Ken、Yazawa Arina、Takahashi Miyuki、Masukawa Daiki、Goshima Yoshio、Hensley Kenneth、Ohshima Toshio
- Journal Title
  
  Journal of the Neurological Sciences
  
  Volume: 413 Pages: 116802-116802
- DOI
  10.1016/j.jns.2020.116802
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06511
[Journal Article] Genetic suppression of CRMP2 phosphorylation improves outcome in MPTP-induced Parkinson’s model mice2019
- Author(s)
  Togashi K, Hasegawa M, Nagai J, Tonouchi A, Masukawa D, Hensley K, Goshima Y, Ohshima T.
- Journal Title
  
  Genes to Cells
  
  Volume: 24 Issue: 1 Pages: 31-40
- DOI
  10.1111/gtc.12651
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06511
[Journal Article] Genetic inhibition of CRMP2 phosphorylation delays Wallerian degeneration after optic nerve injury2019
- Author(s)
  Kinoshita Y, Kondo S, Takahashi K, Nagai J, Wakatsuki S, Araki T, Goshima Y, Ohshima T
- Journal Title
  
  BBRC
  
  Volume: 514 Issue: 4 Pages: 1037-1039
- DOI
  10.1016/j.bbrc.2019.05.060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06511, KAKENHI-PROJECT-17K19945
[Journal Article] Genetic inhibition of CRMP2 phosphorylation at serine 522 promotes axonal regeneration after optic nerve injury2019
- Author(s)
  Kondo S, Takahashi K, Kinoshita Y, Nagai J, Wakatsuki S, Araki T, Goshima Y, Ohshima T
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 7188-7188
- DOI
  10.1038/s41598-019-43658-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06511, KAKENHI-PROJECT-17K19945
[Journal Article] Lanthionine ketimine ester promotes locomotor recovery after spinal cord injury by reducing neuroinflammation and promoting axon growth2017
- Author(s)
  Kotaka K, Nagai J, Hensley K, Ohshima T
- Journal Title
  
  BBRC
  
  Volume: 483 Issue: 1 Pages: 759-764
- DOI
  10.1016/j.bbrc.2016.12.069
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430043
[Journal Article] CRMP1 and CRMP4 are required for proper orientation of dendrites of cerebral pyramidal neurons in the developing mouse brain2017
- Author(s)
  Takaya R, Nagai J, Piao W. Niisato E, Nakabayashi T, Yamazaki Y, Nakamura F, Yamashita N, Kolattukudy P. Goshima Y, Ohshima T
- Journal Title
  
  Brain Res
  
  Volume: 1655 Pages: 161-167
- DOI
  10.1016/j.brainres.2016.11.003
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430043
[Journal Article] Inhibition of CRMP2 phosphorylation repairs CNS by regulating neurotrophic and inhibitory responses.2016
- Author(s)
  Nagai, J., Owada, K., Kitamura, Y., Goshima, Y., Ohshima, T.
- Journal Title
  
  Exp Neurol
  
  Volume: 277 Pages: 283-95
- DOI
  10.1016/j.expneurol.2016.01.015
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-13J05321, KAKENHI-PROJECT-26430043
[Journal Article] Deletion of Crmp4 attenuates CSPG-induced inhibition of axonal growth and induces nociceptive recovery after spinal cord injury.2016
- Author(s)
  Nagai J, Takaya R, Piao W, Goshima Y, Ohshima T.
- Journal Title
  
  Mol Cell Neurosci.
  
  Volume: 74 Pages: 42-48
- DOI
  10.1016/j.mcn.2016.03.006
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-13J05321, KAKENHI-PROJECT-26430043
[Journal Article] Phosphorylation of CRMP2 by Cdk5 regulates dendritic spine development of cortical neuron in the mouse hippocampus2016
- Author(s)
  Jin X, Sasamoto K, Nagai J, Yamazaki Y, Saito K, Goshima Y, Inoue T, Ohshima T.
- Journal Title
  
  Neural Plasticity
  
  Volume: - Pages: 1-7
- DOI
  10.1155/2016/6790743
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430043
[Journal Article] Crmp4 deletion promotes recovery from spinal cord injury by neuroprotection and limited scar formation.2015
- Author(s)
  Nagai, J., Kitamura, Y., Owada, K., Yamashita, N., Takei, K., Goshima, Y., Ohshima, T.
- Journal Title
  
  Sci. Rep.
  
  Volume: 5 Issue: 1 Pages: 8269-8269
- DOI
  10.1038/srep08269
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J05321, KAKENHI-PUBLICLY-26111718, KAKENHI-PROJECT-26290024, KAKENHI-PROJECT-26430043
[Journal Article] Phosphorylation of CRMP2 is involved in proper dendritic field organization2012
- Author(s)
  Yamashita N, Ohshima T, Goshima Y., et al
- Journal Title
  
  J.Neurosci.
  
  Volume: 32 Pages: 1360-1365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500356
[Journal Article] Phosphorylation of CRMP2 is involved in proper dendritic field organization2012
- Author(s)
  Yamashita N, Ohshima T, Nakamura F, Kolattukudy P, Honnorat J, Mikoshiba K, Goshima Y
- Journal Title
  
  J. Neurosci
  
  Volume: 32 Pages: 1360-1365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500356
[Journal Article] Hypomyelination Phenotype Caused by Impaired Differentiation of Oligodendrocytes in Emx1-cre Mediated Cdk5 Conditional Knockout Mice2011
- Author(s)
  He X, Takahashi S, Suzuki H, Hashikawa, T, Kulkarni AB, Mikoshiba K, Ohshima T
- Journal Title
  
  Neurochem Res
  
  Volume: 36 Pages: 1293-1303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500356
[Journal Article] Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emxlcre mediated Cdk5 conditional knockout mice2011
- Author(s)
  He X, Takahashi S, Ohshima T., et al
- Journal Title
  
  Neurochem Res
  
  Volume: 36 Pages: 1293-1303
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500356
[Journal Article] Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation2010
- Author(s)
  Tsutsumi K, Takano T, Endo R, Fukuda M, Ohshima T, Tomomura M, Hisanaga S
- Journal Title
  
  PLoS ONE
  
  Volume: 5(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500356
[Journal Article] Commitment of 1-methyl-4-phenylpyrinidinium ion-induced neuronal cell death by proteasome-mediated degradation of p35 Cyclin-dependent kinase 5 activator2009
- Author(s)
  Endo R, Saito T, Asada A, Kawahara H, Ohshima T, Hisanaga S
- Journal Title
  
  J. Biol. Chem
  
  Volume: 284 Pages: 26029-39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500356
[Journal Article] Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.2009
- Author(s)
  Nakamura F, Ugajin K, Yamashita N, Okada T, Uchida Y, Taniguchi M, Ohshima T, Goshima Y.
- Journal Title
  
  J Comp Neurol 516
  
  Pages: 360-375
- Data Source
  KAKENHI-PROJECT-17082006
[Journal Article] Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.2009
- Author(s)
  Uchida Y, Ohshima T, Yamashita N, Ogawara M, Sasaki Y, Nakamura F, Goshima Y.
- Journal Title
  
  J Biol Chem. 284(40)
  
  Pages: 27393-27401
- Data Source
  KAKENHI-PROJECT-17082006
[Journal Article] Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice2009
- Author(s)
  Nakamura F, Ugajin K, Yamashita N, Okada T, Uchida Y, Taniguchi M, Ohshima T, Goshima Y
- Journal Title
  
  J. Comp. Neurol
  
  Volume: 516 Pages: 360-375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500356
[Journal Article] Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration2009
- Author(s)
  Takahashi S, Ohshima T, Hirasawa M, Pareek TK, Bugge TH, Morozov A, Fujieda K, Brady RO, Kulkarni AB
- Journal Title
  
  American J. Pathology
  
  Volume: 176 Pages: 320-329
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500356
[Journal Article] Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32.2009
- Author(s)
  Uchida Y, Ohshima T, Yamashita N, Ogawara M, Saski Y, Nakamura F, Goshima Y.
- Journal Title
  
  J Biol Chem 284
  
  Pages: 27393-27401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082006
[Journal Article] Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.2009
- Author(s)
  Nakamura F, Ugajin K, Yamashita N, Okada T, Uchida Y, Taniguchi M, Ohshima T, Goshima Y.
- Journal Title
  
  J Comp Neuro1 516
  
  Pages: 360-375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17082006
[Journal Article] Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration and proper dendrite development of pyramidal neurons in the cerebral cortex.2007
- Author(s)
  Toshio Ohshima
- Journal Title
  
  Development 134
  
  Pages: 2273-2282
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18022050
[Journal Article] Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1.2007
- Author(s)
  Yamashita N, Morita A, Uchida Y, Nakamura F, Usui H, Ohshima T, Taniguchi M, Honnorat J, Thomasset N, Takei K, Takahashi T, Kolattukudy P, Goshima Y.
- Journal Title
  
  J Neuroscience 27
  
  Pages: 12546-12554
- Data Source
  KAKENHI-PROJECT-17082006
[Journal Article] Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1.2007
- Author(s)
  Yamashita N, Morita A, Uchida Y, Nakamura F, Usui H, Ohshima T, Taniguchi M, Honnorat J, Thomasset N, Takei K, Takahashi T, Kolattukudy P, Goshima Y.
- Journal Title
  
  J Neuroscience 27巻46号
  
  Pages: 12546-54
- Data Source
  KAKENHI-PROJECT-17082006
[Journal Article] Modulation of Reelin signaling by Cyclin-dependent kinase 52007
- Author(s)
  Toshio Ohshima
- Journal Title
  
  Brain Res. 1140
  
  Pages: 84-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500305
[Journal Article] Modulation of Reeling signaling by Cyclin-dependent kinase 52007
- Author(s)
  Toshio Ohshima
- Journal Title
  
  Brain Res. 1140
  
  Pages: 84-95
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500305
[Journal Article] Modulation of Reelin signaling by Cyclin-dependent kinase 52006
- Author(s)
  T.Ohshimaら
- Journal Title
  
  Brain Research (in press)
- Data Source
  KAKENHI-PROJECT-15500273
[Journal Article] Modulation of Reelin signaling by Cyclin-dependent kinase 5.2006
- Author(s)
  Ohshima, T., Suzuki, H., Morimura, T., Ogawa, M., Mikoshiba, K.
- Journal Title
  
  Brain Res. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500273
[Journal Article] Phosphorylation of the tubulin binding protein, stathmin by Cdk5 and MAP kinase in the brain.2006
- Author(s)
  Hayashi, K., Pan, Y., Shu, H., Ohshima, T., Kansy, W. J., White, CL., Tamminga, C. A., Sobel, A., Curmi, P. A., Mikoshiba, K., Bibb J. A.
- Journal Title
  
  J. Neurochem. 99
  
  Pages: 237-250
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500305
[Journal Article] Collapsin response mediator protein 1 mediates reelin signaling in cortical neuronal migration.2006
- Author(s)
  Yamashita N, Uchida Y, Ohshima T, Hirai S, Nakamura F, Taniguchi M, Mikoshiba K, Honnorat J, Kolattukudy P, Thomasset N, Takei K, Takahashi T, Goshima Y
- Journal Title
  
  J Neurosci 26・51
  
  Pages: 13357-13362
- Data Source
  KAKENHI-PROJECT-17082006
[Journal Article] Modulation of Reelin signaling by Cyclin-dependent kinase 52006
- Author(s)
  T.Ohshima ら
- Journal Title
  
  Brain Reserch (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500273
[Journal Article] Collapsin Response Mediator Protein 1 Mediates Reelin Signaling in Cortical Neuronal Migration.2006
- Author(s)
  Yamashita N, Uchida Y, Ohshima T, Hirai S, Nakamura F, Taniguchi M, Mikoshiba K, Honnorat J, Kolattukudy P, Thomasset N, Takei K, Takahashi T, Goshima Y.
- Journal Title
  
  J. Neurosci. 26
  
  Pages: 13357-13362
- Data Source
  KAKENHI-PROJECT-17082006
[Journal Article] Semaphorin-3A signaling is mediated via sequential Cdk5-GSK3β phosphorylation of CRMP2 : implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease.2005
- Author(s)
  Uchida, Y., Ohshima, T., Sasaki, Y., Suzuki, H., Yanai, S., Yamashita, N., Nakamura, F., Takei, K., Ihara, Y., Mikoshiba, K., Kolattukudy, P., Honnorat, J., Goshima, Y.
- Journal Title
  
  Genes to Cells 10
  
  Pages: 165-179
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500273
[Journal Article] Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice2005
- Author(s)
  T.Ohshimaら
- Journal Title
  
  J.Neurochem. 94
  
  Pages: 917-925
- Data Source
  KAKENHI-PROJECT-15500273
[Journal Article] Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice.2005
- Author(s)
  Ohshima, T., Ogura, H., Tomizawa, K., Hayashi, K., Suzuki, H., Saito, T., Kamei, H., Nishi, A., Bibb, J.A., Hisanaga, S, Matsui, H., Mikoshiba, K.
- Journal Title
  
  J Neurochem. 94
  
  Pages: 917-925
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15500273
[Journal Article] Impairment of hippocampal long-term depression and defective spatial learning and memory in p35 mice2005
- Author(s)
  T.Ohshima ら
- Journal Title
  
  J. Neurochem. 94
  
  Pages: 917-925
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15500273
[Presentation] ランチオニンケチミンエステルによる神経炎症抑制と軸索伸長を介した脊髄損傷後の後肢運動機能の向上2016
- Author(s)
  小高謙, Kenneth Hensley, 大島登志男
- Organizer
  第39回日本分子生物学年会
- Place of Presentation
  横は野
- Data Source
  KAKENHI-PROJECT-26430043
[Presentation] Dephosphorylation of CRMP2 enhances recovery after spinal cord injury2015
- Author(s)
  Jun Nagai, Kazuki Owada, Yoshiteru Kitamura, Yoshio Goshima, Toshio Ohshima
- Organizer
  SfN Annual Meeting “Neuroscience 2015"
- Place of Presentation
  シカゴ・USA
- Year and Date
  2015-10-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430043
[Presentation] CRMP2 dephosphorylation induces locomotor and sensory recovery after spinal cord injury2015
- Author(s)
  Jun Nagai, Kazuki Owada, Yoshiteru Kitamura, Yoshio Goshima, Toshio Ohshima
- Organizer
  BMB2015
- Place of Presentation
  神戸
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-26430043
[Presentation] Genetic modifications of Crmp enhance axonal regrowth after spinal cord injury by reducing cytoskeletal destabilization and inflammatory responses2014
- Author(s)
  J. Nagai, Y. Kitamura, K. Owasa, Y. Goshima, T. Ohshima
- Organizer
  SFN Neuroscience meeting 2014
- Place of Presentation
  Washijgton D.C., USA
- Year and Date
  2014-11-18
- Data Source
  KAKENHI-PROJECT-26430043
[Presentation] Collapsin response mediator proteins regulate bifurcation of apical dendrites in hippocampal CA1 pyramidal neurons during the brain development2011
- Author(s)
  Niisato E, Nagai, J, Yamashita N, Nakamura F, Goshima Y, and Ohshima T
- Organizer
  2011 SFN annual meeting
- Place of Presentation
  Washington DC, USA
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-21500356
[Presentation] Role of collapsin response mediator proteins for dendritic development in hippocampal CA1 pyramidal neurons2010
- Author(s)
  Niisato E, Yamashita N, Nakamura F, Goshima Y, Ohshima T
- Organizer
  Neuro 2010
- Data Source
  KAKENHI-PROJECT-21500356
[Presentation] Hypomyelination phenotype caused by impaired differentiation of oligodendrocytes in Emx1-cre mediated Cdk5 conditional knockout mice2010
- Author(s)
  He X, Takahashi S, Suzuki H, Hashikawa T, Kulkarni AB, Mikoshiba K, Ohshima T
- Organizer
  BMB 2010
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-12-07
- Data Source
  KAKENHI-PROJECT-21500356
[Presentation] Sema3A regulates apical dendritic growth of hippocampal CA1 pyramidal neurons2009
- Author(s)
  Nakamura F, Ugajin N, Yamashita M, Taniguchi M, Ohshima T, Goshima Y
- Organizer
  32th Japan Neuroscience Society Meeting
- Place of Presentation
  東京
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-17082006
[Presentation] Cdk5 is required for multipolar-to-bipolar transition during radial neuronal migration in the cerebral cortex.2007
- Author(s)
  Toshio Ohshima
- Organizer
  Neuro2007
- Place of Presentation
  Yokohama
- Year and Date
  2007-09-10
- Data Source
  KAKENHI-PROJECT-18022050
[Presentation] CRMP1 regulates spine maturation through mediating Semaphorin3A signaling in vivo.2007
- Author(s)
  Yamashita N, Morita A, Uchida Y, Ohshima T, Nakamura F, Usui H, Honnorat J, Kolattukudy P, Thomasset N, Goshima Y
- Organizer
  Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-17082006
[Presentation] Role of Cdk5 in brain development and function2007
- Author(s)
  Ohshima T.
- Organizer
  Croucher Symposium The Roles of Cdk5 in Neuronal development, Synaptic Plasticity & Neurodegenerative diseases
- Place of Presentation
  HongKong, China
- Year and Date
  2007-01-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500305
[Presentation] Role of Cdk5 in brain development and function2007
- Author(s)
  Toshio Ohshima
- Organizer
  Croucher Symposium "The Roles of Cdk5 in Neuronal development, Synaptic Plasticity & Neurodegenerative diseases"
- Place of Presentation
  Hong Kong, China
- Year and Date
  2007-01-09
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500305

1. GOSHIMA Yoshio (00153750)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. Yamamura Takashi (90231670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 中村史雄 (10262023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
4. 鈴木厚 (00264606)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 大木伸司 (50260328)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 北條浩彦 (60238722)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 林幼偉 (80392439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 佐藤和貴郎 (90469990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 服部正平 (70175537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 土居芳充 (20597174)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. NAGAI Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
12. 内田穣

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 原田高幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 行方和彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohshima Toshio 大島 登志男

OOSHIMA Toshio 大島 登志男

大島 登志雄 オオシマ トシオ

大島 登志男 オオシマ トシオ

Research Projects

Research Products

Co-Researchers

神経炎症とCRMPの関連の解明と神経疾患治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the role of CRMP2 phosphorylation in neural circuit formation and regenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study to develop therapeutic strategy of neurodegenerative disorders by targeting on CRMPPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Cross-talk between endocrine and environmental factors in neuroimmune disorders

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of roles of CRMP in neural circuit formation and regeneration and application for the treatment of spinal cord injuryPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of Cdk5 by using conditional KO of its activating subunit p35Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

誘導型コンディショナルKOを用いたCdk5の脳機能における役割の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Proteomics of phospho-proteins during brain development using mutant micePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of CRMP family proteins in the establishment of neural tissue architectures

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification and functional analysis of Cdk5-mediated phosphorylation of the proteins that are related to brain formation and developmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経特異的サイクリン依存性キナーゼ(cdk5)の個体レベルでの機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 神経特異的キナーゼCdk5の神経発達と神経変性への関与. Brain Science Review 20102010

Author(s)

Publisher

Data Source

[Journal Article] CRMP2 and its phosphorylation prevent axonal misrouting of the corticospinal tract2025

Author(s)

Journal Title

Ohshima Toshio 大島登志男

OOSHIMA Toshio 大島登志男

大島登志雄オオシマトシオ

大島登志男オオシマトシオ