Takahashi Tomoyuki 高橋知之

… Alternative Names

TAKAHASHI Tomoyuki 高橋知之

高橋智之タカハシトモユキ

高橋和之タカハシカズユキ

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Researcher Number	20332687
Other IDs
External Links
Affiliation (Current)	2025: 久留米大学, 付置研究所, 教授 2025: 久留米大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2024: 久留米大学, 付置研究所, 教授 2023: 久留米大学, 医学部, 教授 2023: 久留米大学, 高次脳疾患研究所, 教授 2009 – 2023: 久留米大学, 医学部, 准教授 2008: Kurume University, 高次脳疾患研究所, 准教授 … More 2007: Kurume University, 医学部, 准教授 2004 – 2006: 久留米大学, 医学部, 助教授 2001 – 2003: 岐阜大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Pediatrics / Circulatory organs internal medicine / Basic Section 52050:Embryonic medicine and pediatrics-related / Circulatory organs internal medicine Except Principal Investigator Pediatrics / Basic Section 52050:Embryonic medicine and pediatrics-related / Pediatrics / Circulatory organs internal medicine / Circulatory organs internal medicine
Keywords	Principal Investigator レット症候群 / Rett症候群 / MeCP2 / 再生療法 / 心筋発生・分化 / ヒトES細胞 / 心臓 / 注意欠如・多動症 / 自閉スペクトラム症 / 神経発達症 … More / rett症候群 / Mecp2 / 再生医学 / 疾患モデル / iPS細胞 / レット症候群(RTT) / Rett 症候群 / 心筋分化・発生 / 心臓病態学 / 発生・分化 / 胚性幹細胞 / 分化 / アクチン細胞骨格 / サルコメア / LIMキナーゼ … More Except Principal Investigator レット症候群 / iPS細胞 / 不整脈 / ES細胞 / グレリン / モデル動物 / トランスレーショナルリサーチ / 自律神経 / 振戦 / ジストニア / 肺炎 / MECP2遺伝子 / Rett症候群 / Regenerative medicine / 再生医学 / 心筋細胞 / ghrelin / 心臓分化 / SHANK3遺伝子 / 発達障害 / 遺伝子 / １型インターフェロン / 自然免疫 / ミクログリア / Ⅰ型インターフェロン / Aicardi-Goutieres症候群 / MDA5 / IFIH1 / Type I interferonopathy / エカルディ・グティエール症候群 / G欠損狂犬病ウイルストレーシング法 / 三次元画像再構築 / 分化転換 / 自律神経機能障害 / 心交感神経 / 体タンパク質 / ｍTOC1 / オルニチン / アルギニン / グルタミノリシス / グルタミン酸 / ジメチルa-ケトグルタル酸 / 尿素サイクル / アンモニア / α-ケトグルタル酸Na / 治療 / タンパク質合成 / mTORC1 / α-ケトグルタル酸 / 高アンモニア血症 / 突然死 / ホルター心電計 / 睡眠 / 神経伝達物質 / 自律神経症状 / バイオマーカー / 全エキソーム解析 / 自閉症スペクトラム / MECP2 / HDAC8遺伝子 / STXBP1遺伝子 / 自閉症スペクトラム障害 / Transplantation / Development and differentiation / Gene / 移植・再生医療 / 発生・分化 / Cardiomyocyte / Gene expression / Adenoviral vector / Congenital disease / Vector / Gene transfer / ES cell / 遺伝子発現 / アデノウイルスベクター / 先天疾患 / ベクター / 遺伝子導入 / ATP-sensitive K channel / metabolic inhibition / myocyte / differentiation and induction / embryonic stem cell / 超微形態 / L型Caチャネル / パッチクランプ法 / イオンチャネル / ATP感受性Kチャネル / 代謝抑制 / 分化誘導 / 初代培養細胞 / 骨髄移植 / レット症候群モデル動物 / 成長 / イオンチャンネル / QT延長 / IGF-1 / モデルマウス / MeCP2 / 遺伝子治療 / 細胞移植 / リモデリング / 心筋梗塞 / Remodeling / Myocardial infarction / Integrins / Heart failure / Cell therapy / 脳神経疾患 / 生理活性 / Translational Research / 脳神経科学 / 遺伝子解析 / ペプチドホルモン / 神経内分泌 / 脳発達 / デカノイルグレリン / 臨床応用 / 摂食障害 / 神経内分泌ホルモン / 神経内分泌調節 / Rett 症候群 / 発達小児科学 / 病因 / 医療・福祉 / ケモカイン / サイトカイン / 樹状細胞 / 川崎病 / バイオテクノロジー / 癌 / ウイルス Less

Analysis of developmental disorder phenotypes in mouse models of Rett Syndrome for drug discoveryPrincipal Investigator
- Principal Investigator
  
  高橋知之
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kurume University
Elucidation of pathophysiology of Aicardi-Goutieres syndrome by cellular engineering technology
- Principal Investigator
  
  西小森隆太
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kurume University
Novel therapeutic strategy for hyperammonemia based on nitrogen repositioning by the use of low molecular biological compounds
- Principal Investigator
  
  芳野信
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kurume University
Does neurotransmitter switch of autonomic nerve lead to disturb heart-brain interaction of Rett syndrome?
- Principal Investigator
  
  原宗嗣
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kurume University
Analysis of sleep disorder phenotypes in mouse models of Rett Syndrome for drug discoveryPrincipal Investigator
- Principal Investigator
  
  Takahashi Tomoyuki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kurume University
Basic and clinical research to esatblsh biological markers for Rett syndrome
- Principal Investigator
  
  Matsuishi Toyojiro
- Project Period (FY)
  2018 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Kurume University
Development of innovative therapies for Rett syndrome with cell transplantation and functions control of microgliaPrincipal Investigator
- Principal Investigator
  
  Takahashi Tomoyui
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Basic and clinical research for clarify the pathophysiology and development of new terapeutic trial for Rett syndrome
- Principal Investigator
  
  Matsuishi Toyojiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Glial cells differentiation of MeCP2 deficient ES/iPS cells and pathophysiology of Rett syndromePrincipal Investigator
- Principal Investigator
  
  TAKAHASHI TOMOYUKI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Reinforcement of infarct scar by targeted transplantation of myofibroblasts reverses postinfarction cardiac remodeling
- Principal Investigator
  
  GENZOU Takemura
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Asahi University
  Gifu University
Basic and clinical research for innovated biological marker and new treatment strategy inpatients with Rett syndrome
- Principal Investigator
  
  TOYOJIRO MATSUISHI
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Generation of iPS cells derived form an Rett syndrome model mouse and drug screening for Rett syndrome using MeCP2 deficient iPS cellsPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Tomoyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Clinical and basic studies on the dynamics of ghrelin in Rett syndrome (RTT) together with a pilot-study on the clinical implication of ghrelin for the treatment of RTT-patients.
- Principal Investigator
  
  NISHI Yoshihiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Involvement of dendritic cells in pathophysiology of the acute phase of Kawasaki disease
- Principal Investigator
  
  SUDA Kenji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
Development of innovative gene therapy of conditionally regulating adenovirus for treating pediatric solid cancer
- Principal Investigator
  
  KOSAI Kenichirou
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kagoshima University
A novel biotechnology of gene therapy and human embryonic stem cells for regenerative medicinePrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Tomoyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kurume University
ヒトES細胞による心筋発生・分化機構の解明と再生療法の開発Principal Investigator
- Principal Investigator
  
  高橋知之
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kurume University
Development of innovative regenerative medicine for pediatric heart diseases using human ES cell and gene therapy technology
- Principal Investigator
  
  KOSAI Kenichiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kagoshima University
  Kurume University
新しい目的細胞同定法による胚性幹細胞由来心筋細胞の特性解析と細胞移植療法の開発Principal Investigator
- Principal Investigator
  
  高橋知之
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kurume University
  Gifu University
Ion channel property and ultrastructure in myocyte differentiated and induced from embryonic stem cells.
- Principal Investigator
  
  TSUCHIYA Kunihiko
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  GIFU UNIVERSITY
Development of novel regenerative medicine for congenital diseases using gene therapy biotechnology and embryonic stem cell
- Principal Investigator
  
  KOSAI Ken-ichiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kurume University
  Gifu University
LIMキナーゼ遺伝子の心臓発生過程における機能的役割の解析Principal Investigator
- Principal Investigator
  
  高橋知之 (高橋和之)
- Project Period (FY)
  2001 – 2002
- Research Category
  
  若手研究(B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Gifu University

[Book] 7.HGF 急性/劇症肝炎.「細胞増殖因子と再生医療」(199-204)2006
- Author(s)
  高橋知之
- Total Pages
  401
- Publisher
  メディカルレビュー社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591126
[Book] "急性/劇症肝炎"7.HGF 細胞増殖因子と再生医療2006
- Author(s)
  高橋知之
- Publisher
  メディカルレビュー社(in press)
- Data Source
  KAKENHI-PROJECT-17790509
[Book] 7.HGF 急性/劇症肝炎.「細胞増殖因子と再生医療」(199-204)2006
- Author(s)
  高橋知之
- Total Pages
  401
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-17591126
[Book] ES細胞再生医学の新技術開発- ヒトES細胞と遺伝子治療技術- 再生医療 5巻1号,43-512006
- Author(s)
  高橋知之
- Total Pages
  155
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-17591126
[Book] "急性/劇症肝炎"7.HGF細胞増殖因子と再生医療2006
- Author(s)
  高橋知之, 他
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-17790509
[Book] 再生医療(日本再生医療学会雑誌)5(1) : 43-512006
- Author(s)
  高橋知之
- Total Pages
  155
- Publisher
  ES細胞再生医学の新技術開発- ヒトES細胞と遺伝子治療技術-
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591126
[Journal Article] Moving towards a novel therapeutic strategy for hyperammonemia that targets glutamine metabolism2022
- Author(s)
  Fukui K, Takahashi T, Matsunari H, Uchikura A, Watanabe M, Nagashima H, Ishihara N, Kakuma T, Watanabe Y, Yamashita Y, Yoshino M
- Journal Title
  
  J Inherit Metab Dis
  
  Volume: 46(6) Issue: 6 Pages: 1059-1069
- DOI
  10.1002/jimd.12540
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08198, KAKENHI-PROJECT-21K07811
[Journal Article] Perampanel markedly improved clinical seizures in a patient with a Rett-like phenotype and 960-kb deletion on chromosome 9q34.11 including the STXBP12022
- Author(s)
  4.Yoshida S., Amamoto M., Takahashi T., Tomita I., Yuge K., Hara M., Iwama K., Matsumoto N., Matsuishi T.
- Journal Title
  
  Clin Case Rep
  
  Volume: in press Issue: 5 Pages: 1-7
- DOI
  10.1002/ccr3.5811
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08198, KAKENHI-PROJECT-18K07893, KAKENHI-PROJECT-21K07858, KAKENHI-PROJECT-22K15952
[Journal Article] Early diagnosis of MECP2 duplication syndrome: Insights from a nationwide survey in Japan.2021
- Author(s)
  Takeguchi R, Takahashi S, Akaba Y, Tanaka R, Nabatame S, Kurosawa K, Matsuishi T, Itoh M.
- Journal Title
  
  J Neurol Sci
  
  Volume: 422 Pages: 117321-117321
- DOI
  10.1016/j.jns.2021.117321
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08322, KAKENHI-PROJECT-18K07893
[Journal Article] Optimization of Adenoviral Gene Transfer in Human Pluripotent Stem Cells2021
- Author(s)
  Mitsui K., Takahashi T., Ide K., Matsuda E., Kosai K.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 541 Pages: 78-83
- DOI
  10.1016/j.bbrc.2021.01.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08198, KAKENHI-PROJECT-20K21580, KAKENHI-PROJECT-19K08562, KAKENHI-PROJECT-20H03645
[Journal Article] Case Report: Rituximab Improved Epileptic Spasms and EEG Abnormalities in an Infant with West Syndrome and Anti-NMDAR Encephalitis Associated With APECED2021
- Author(s)
  Kawano G, Yokochi T, Nishikomori R, Watanabe Y, Ohbu K, Takahashi Y, Shintaku H, Matsuishi T
- Journal Title
  
  Front Neurol
  
  Volume: 12
- DOI
  10.3389/fneur.2021.679164
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07893, KAKENHI-PROJECT-21K07788
[Journal Article] Meaningful word acquisition is associated with walking ability over 10 years in Rett syndrome2020
- Author(s)
  Saikusa T, Kawaguchi M, Tanioka T, Nabatame S, Takahashi S, Yuge K, Nagamitsu S, Takahashi T, Yamashita Y, Kobayashi Y, Hirayama C, Kakuma T, Matsuishi T, Itoh M.
- Journal Title
  
  Brain Dev
  
  Volume: 42(10) Issue: 10 Pages: 705-712
- DOI
  10.1016/j.braindev.2020.06.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08198, KAKENHI-PROJECT-18K15692
[Journal Article] レット症候群の病態とMeCP2の多様な役割．総説―医学・医療の最前線シリーズ2018
- Author(s)
  高橋知之，弓削康太郎，松石豊次郎，山下裕史朗
- Journal Title
  
  久留米医学会雑誌
  
  Volume: 81 Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07893
[Journal Article] レット症候群の病態とMeCP2の多様な役割2018
- Author(s)
  高橋知之・弓削康太郎・松石豊次郎・山下裕史朗
- Journal Title
  
  久留米医学会雑誌
  
  Volume: Vol.81 No.11,12 Pages: 265-272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10002
[Journal Article] Cervical dystonia in Parkinson's disease: Retrospective study of later-stage clinical features2018
- Author(s)
  Kida H., Miura S., Yamanishi Y., Takahashi T., Kamada T., Yorita A., Ayabea M., Kida H., Hoshino T., Taniwaki T.
- Journal Title
  
  Neurol Asia
  
  Volume: 23(3) Pages: 245-251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10002
[Journal Article] Pathogenesis of Lethal Aspiration Pneumonia in Mecp2-null Mouse Model for Rett Syndrome.2017
- Author(s)
  Hiroshi Kida, Tomoyuki Takahashi, Yuki Nakamura, Takashi Kinoshita, Munetsugu Hara, Masaki Okamoto, Satoko Okayama, Keiichiro Nakamura, Ken-ichiro Kosai, Takayuki Taniwaki, Yushiro Yamashita, Toyojiro Matsuishi
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 12293-12298
- DOI
  10.1038/s41598-017-12293-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09365, KAKENHI-PROJECT-16K00934, KAKENHI-PROJECT-16K10002, KAKENHI-PROJECT-15K19642, KAKENHI-PROJECT-16H01880, KAKENHI-PROJECT-15K09608
[Journal Article] Viral Vector-Based Innovative Approaches to Directly Abolishing Tumorigenic Pluripotent Stem Cells for Safer Regenerative Medicine.2017
- Author(s)
  Mitsui K, Ide K, Takahashi T, Kosai K.
- Journal Title
  
  Mol Ther Methods Clin Dev
  
  Volume: 5 Pages: 51-58
- DOI
  10.1016/j.omtm.2017.03.002
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293234, KAKENHI-PROJECT-16K10002, KAKENHI-PROJECT-15K19389
[Journal Article] Intravenous Administration of Endothelial Colony-Forming Cells Overexpressing Integrin β1 Augments Angiogenesis in Ischemic Legs2016
- Author(s)
  Goto K., Takemura G., Takahashi T., Okada H., Kanamori H., Kawamura I., Watanabe T., Morishita K., Tsujimoto A., Miyazaki N., Ushikoshi H., Kawasaki M., Mikami A., Kosai K., Minatoguchi S.
- Journal Title
  
  Stem Cells Transl Med
  
  Volume: 5 Issue: 2 Pages: 218-226
- DOI
  10.5966/sctm.2015-0096
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25461568, KAKENHI-PROJECT-25670194, KAKENHI-PROJECT-25293234, KAKENHI-PROJECT-16K10002
[Journal Article] Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2-null mice to arrhythmias.2015
- Author(s)
  Hara M, Takahashi T, Mistumasu C, Igata S, Takano M, Minami T, Yasukawa H, Okayama S, Nakamura K, Okabe Y, Tanaka E, Takemura G, Kosai K, Yamashita Y, Matsuishi T.
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 11204-11204
- DOI
  10.1038/srep11204
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461137, KAKENHI-PROJECT-25461568, KAKENHI-PROJECT-25670194, KAKENHI-PROJECT-26670292, KAKENHI-PROJECT-26860832, KAKENHI-PROJECT-24300145, KAKENHI-PROJECT-25293234
[Journal Article] Disturbance of cardiac gene expression and cardiomyocyte structure predisposes Mecp2－nu11 mice to arrhythmias2015
- Author(s)
  Hara M,Takahashi T,Mitsumasu C,Igata S,Takano M,Minami T,Yasukawa H,Okayama S,Nakamura K,Okabe Y,Tanaka E,Takemura G,Kosai K,Yamashita Y,Matsuishi T
- Journal Title
  
  Cientific Reports
  
  Volume: 5 Pages: 11204-11204
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K09608
[Journal Article] Disruption of MeCP2 attenuates circadian rhythm in CRISPR/Cas9-based Rett syndrome model mouse.2015
- Author(s)
  Tsuchiya Y., Minami Y., Umemura Y., Watanabe H., Ono D., Nakamura W., Takahashi T., Honma S., Kondoh G., Matsuishi T. & Yagita K.
- Journal Title
  
  Genes to Cells
  
  Volume: 20 Issue: 12 Pages: 992-1005
- DOI
  10.1111/gtc.12305
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08212, KAKENHI-PROJECT-15K09608, KAKENHI-PROJECT-26462809, KAKENHI-PROJECT-15K21098, KAKENHI-PROJECT-26860156, KAKENHI-PLANNED-24119004, KAKENHI-PROJECT-25250012, KAKENHI-PROJECT-15H04683, KAKENHI-PROJECT-25461568
[Journal Article] Intramuscular injection of adenoviral hepatocyte growth factor at a distal site ameliorates dextran sodium sulfate-induced colitis in mice2014
- Author(s)
  Yuge K, Takahashi T, Khai NC, Goto K, Fujiwara T, Fujiwara H, Kosai K
- Journal Title
  
  Int J Mol Med
  
  Volume: 33(5) Issue: 5 Pages: 1064-1074
- DOI
  10.3892/ijmm.2014.1686
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659159, KAKENHI-PROJECT-25293234, KAKENHI-PROJECT-25461568, KAKENHI-PROJECT-25670194
[Journal Article] Involvement of circulating myeloid dendritic cells in the pathogenesis of acute Kawasaki disease in human.2013
- Author(s)
  Suda K, Kishimoto S, Nishino H, Takahashi, T, Okamura H, Teramachi Y, Yokoyama T, Yasukawa H, Imaizumi T, Matsuishi T.
- Journal Title
  
  J Clin Exp Cardiology
  
  Volume: 4 Issue: 10 Pages: 272-272
- DOI
  10.4172/2155-9880.1000272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591094, KAKENHI-PROJECT-24730613, KAKENHI-PROJECT-25461568
[Journal Article] Two neonatal cholestsis patients with mutations in the SRD5B1 (AKR1D1) gene: diagnosis and bile acid profiles during chenodeoxycholic acid treatment.2013
- Author(s)
  Seki, Y., Mizuochi, T., Kimura, A., Takahashi T., Ohtake, A., Hayashi, S., Morimura, T., Ohno, Y., Hoshina, T., Ihara, K., Takei, H., Nittono H., Kurosawa T., Homma K., Hasegawa T., Matsuishi T.
- Journal Title
  
  J Inherit Metab Dis
  
  Volume: 36(3) Issue: 3 Pages: 565-573
- DOI
  10.1007/s10545-012-9526-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591144, KAKENHI-PROJECT-22791008, KAKENHI-PROJECT-24591531, KAKENHI-PROJECT-25461568
[Journal Article] Alterations of Gene Expression and Glutamate Clearance in Astrocytes Derived from an MeCP2-null Mouse Model of Rett Syndrome2012
- Author(s)
  Okabe Y., Takahashi T., et al
- Journal Title
  
  PLoS One
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591144
[Journal Article] Alterations of Gene Expression and Glutamate Clearance in Astrocytes Derived from an MeCP2-null Mouse Model of Rett Syndrome2012
- Author(s)
  Okabe Y, Takahashi T, Mitsumasu C, Kosai K, MD, Tanaka E, Matsuishi T
- Journal Title
  
  PLoS ONE
  
  Volume: 7(4) Issue: 4 Pages: e35354-e35354
- DOI
  10.1371/journal.pone.0035354
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390210, KAKENHI-PROJECT-22591144, KAKENHI-PROJECT-23590269, KAKENHI-PROJECT-23659159, KAKENHI-PROJECT-24591531, KAKENHI-PROJECT-24591532
[Journal Article] Rett症候群の病態に関する神経生化学的研究"特集2:自閉症スペクトラム障害の脳機能病態、査読無2011
- Author(s)
  山下裕史朗・原宗嗣・高橋知之・松石豊次郎
- Journal Title
  
  日本生物学的精神医学会誌
  
  Volume: Vol.22No.1 Pages: 45-49
- Data Source
  KAKENHI-PROJECT-22591144
[Journal Article] Rett syndrome : The state of clinical basic research, and future perspectives.2011
- Author(s)
  Matsuishi T., Takahashi T., et al.
- Journal Title
  
  Brain Dev
  
  Volume: (in press)
- NAID
  10031121966
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591144
[Journal Article] Rett syndrome : The state of clinical basic research, and future perspectives2011
- Author(s)
  Matsuishi T., Takahashi T., et al
- Journal Title
  
  Brain Dev
  
  Volume: 33(8) Pages: 627-631
- NAID
  10031121966
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591144
[Journal Article] Ghrelin levels are reduced in Rett syndrome with eating difficulties.2011
- Author(s)
  Hara M, Nishi Y, Yamashita Y, Yoh J, Takahashi S, Nagamitsu S, Kakuma T, Hosoda H, Kangawa K, Kojima M, Matsuishi T.
- Journal Title
  
  International Journal of Develop-mental Neuroscience
  
  Volume: 29 Pages: 899-902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591145
[Journal Article] The state of clinical basic research, and future perspectives.2011
- Author(s)
  Matsuishi T., Yamashita Y., Takahashi T., Nagamitsu S.Rett syndrome
- Journal Title
  
  Brain Dev
  
  Volume: 33(8) Issue: 8 Pages: 627-631
- DOI
  10.1016/j.braindev.2010.12.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591144, KAKENHI-PROJECT-22591145
[Journal Article] Increased Plasma Type B Natriuretic Peptide in The Acute Phase of Kawasaki Disease2011
- Author(s)
  Kishimoto S., Takahashi T., et al
- Journal Title
  
  Pediatr Int
  
  Volume: 53(5) Pages: 736-741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591144
[Journal Article] Increased Plasma Type B Natriuretic Peptide in The Acute Phase of Kawasaki Disease.2011
- Author(s)
  Kishimoto S., Takahashi T., et al.
- Journal Title
  
  Pediatr Int
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591144
[Journal Article] Increased plasma type B natriuretic peptide in the acute phase of Kawasaki disease2011
- Author(s)
  Kishimoto S, Suda K, Teramachi Y, Nishino H, Kudo Y, Ishii H, Iemura M, Takahashi T, Okamura H, Matsuishi T.
- Journal Title
  
  Pediatr Int
  
  Volume: 53 Issue: 5 Pages: 736-41
- DOI
  10.1111/j.1442-200x.2011.03351.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591401, KAKENHI-PROJECT-22591144
[Journal Article] Anti-Fas Gene Therapy Prevents Doxorubicin-induced Acute Cardiotoxicity through Mechanisms Independent of Apoptosis2010
- Author(s)
  Miyata S, Takemura G, Kosai KI, Takahashi T, Esaki M, Li L, Kanamori H, Maruyama R, Goto K, Tsujimoto A, Takeyama T, Kawaguchi T, Ohno T, Nishigaki K, Fujiwara T, Fujiwara H, Minatoguchi S.
- Journal Title
  
  The American Journal of PATHOLOGY 176(2)
  
  Pages: 687-698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390286
[Journal Article] Molecular genetics and bile acid profiles of 3beta-hydroxy-delta 5-C27-steroid dehydrogenase/isomerase deficiency in 2 Japanise patients.2010
- Author(s)
  Mizuochi T., Takahashi T., et al.
- Journal Title
  
  Pediatr Res
  
  Volume: 68 Pages: 258-263
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591144
[Journal Article] Anti-Fas Gene Therapy Prevents Doxorubicin-induced Acute Cardiotoxicity through Mechanisms Independent of Apoptosis2010
- Author(s)
  Miyata S, Takemura G, Kosai K, Takahashi T, Esaki M, Li L, Kanamori H, Maruyama R, Goto K, Tsujimoto A, Takeyama T, Kawaguchi T, Ohno T, Nishigaki K, Fujiwara T, Fujiwara H, Minatoguchi S
- Journal Title
  
  Am J Pathol
  
  Volume: 176(2) Issue: 2 Pages: 687-98
- DOI
  10.2353/ajpath.2010.090222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390210, KAKENHI-PROJECT-22591144
[Journal Article] These authors were equally contributed to this work.)Neural Development ofMethyl-CpG-Binding Protein 2 Null Embryonic Stem Cells: A System for Studying Rett Syndrome.2010
- Author(s)
  *Okabe Y., *Kusaga A., * Takahashi T., Mitsumasu C., Murai Y., Tanaka E., Higashi H., Matsuishi T., Kosai K.
- Journal Title
  
  Brain Res
  
  Volume: 1360 Pages: 17-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591144
[Journal Article] Molecular genetics and bile acid profiles of 3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase deficiency in 2 Japanise patients.2010
- Author(s)
  Mizuochi T., Kimura A., Ueki I., Takahashi T., Hashimoto T., Takao A., Seki Y., Takei H., Nittono H., Kurosawa T., Matsuishi T.
- Journal Title
  
  Pediatr Res
  
  Volume: 68(3) Pages: 258-263
- DOI
  10.1203/00006450-201011001-00505
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591144, KAKENHI-PROJECT-22791008
[Journal Article] Neural Development of Methyl-CpG-Binding Protein 2 Null Embryonic Stem Cells : A System for Studying Rett Syndrome.2010
- Author(s)
  Okabe Y, Takahashi T., et al.
- Journal Title
  
  Brain Res
  
  Volume: 1360 Pages: 17-27
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591144
[Journal Article] Postinfarction gene therapy with adenoviral vector expressing decorin mitigates cardiac remodeling and dysfunction2009
- Author(s)
  Li L, Okada H, Takemura G, Kosai KI, Kanamori H, Esaki M, Takahashi T, Goto K, Tsujimoto A, Maruyama R, Kawamura I, Kawaguchi T, Takeyama T, Fujiwara T, Fujiwara H, Minatoguchi S.
- Journal Title
  
  American journal of physiology : Heart and circulatory physiology 294(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390286
[Journal Article] Combined therapy with cardioprotective cytokine administration and antiapoptotic gene transfer in postinfarction heart failure.2009
- Author(s)
  Okada H., Takemura G., Kosai KI., Tsujimoto A., Esaki M., Takahashi T., Nagano S., Kanamori H., Miyata S., Li Y., Ohno T., Maruyama R., Ogino A., Li L., Nakagawa M., Nagashima K., Fujiwara T., Fujiwara H., Minatoguchi S.
- Journal Title
  
  Am J Physiol : Heart and Circulatory Physiology 296(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790547
[Journal Article] Combined therapy with cardioprotective cytokine administration and anti-apoptotic gene transfer in postinfarction heart failure2009
- Author(s)
  Okada M., Takemura G., Kosai K., Takahashi T., et.al.
- Journal Title
  
  Am J Physiol : Heart and Circulatory Physiology 296(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790547
[Journal Article] Treatment with an adenoviral vector encoding hepatosyte growth factor mitigates established cardiac dysfunction in doxorubicin -induced cardiotnyopathy.2008
- Author(s)
  Esaki M, Takemura G, Kosai KI, Takahashi T, Miyata S, Li L, Goto K, Maruyama R, Okada H, Kanamori, H, Ogino A, Ushikoshi H, Minatoguchi S, Fujiwara T, Fujiwara H.
- Journal Title
  
  Am J Physiol Heart Circ Physiol. 294(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390286
[Journal Article] Treatment with an adenoviral vector encoding hepatocyte growth factor mitigates est ablished cardiac dysfunction in doxorubicin-induced cardiomyopathy2008
- Author(s)
  Esaki M., Takemure G., Kosai K., Takahashi T., et. al.
- Journal Title
  
  Am J Physiol: Heart and Circulatory Physiology 294(2)
  
  Pages: 1048-1057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790547
[Journal Article] Application of an adenoviral vector encoding soluble transforming growth factor-betatype II receptor to the treatment of diabetic nephropathy in mice2008
- Author(s)
  Kondo T., Takemura G., Kosai K., Ohno T., Takahashi T., et.al.
- Journal Title
  
  Clin Exp Pharmacol Physiol. 35(11)
  
  Pages: 1288-1293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790547
[Journal Article] Application of an adenoviral vector encoding soluble transforming growth factor-beta type II receptor to the treatment of diabetic nephropathy in mice2008
- Author(s)
  Kondo T., Takemura G., Kosai K., Ohno T., Takahashi T., Esaki M.,Goto K., Maruyama R., Murata I., Minatoguchi S., Fujiwara T., Fujiwara H.
- Journal Title
  
  Clin Exp Pharmacol Physiol 35(11)
  
  Pages: 1288-1293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790547
[Journal Article] Treatment with an adenoviral vector encoding hepatosyte growth factor mitigates established cardiac dysfunction in doxorubicin-induced cardiomyopathy.2008
- Author(s)
  Esaki M, Takemura G, KosaiKI, Takahashi T, Miyata S, Li L, Goto K, Maruyama R, Okada H, Kanamori H, Ogino A, Ushikoshi H, Minatoguchi S, Fujiwara T, Fujiwara H.
- Journal Title
  
  Am J Physiol Heart Circ Physiol. 294(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390286
[Journal Article] Treatment with an adenoviral vector encoding hepatocyte growth factor mitigates established cardiac dysfunction in doxorubicin-induced cardiomyopathy2008
- Author(s)
  Esaki M., Takemura G., Kosai K., Takahashi T., Miyata S., Li L., Goto K., Maruyama R., Okada H., Kanamori H., Ogino A., Ushikoshi H., Minatoguchi S., Fujiwara T., Fujiwara H.
- Journal Title
  
  Am J Physiol : Heart and Circulatory Physiology 294(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790547
[Journal Article] Treatment with an adenoviral vector encoding hepatocyte growth factor mitigates established cardiac dysfunction in doxorubicin-induced cardiomyopathy2008
- Author(s)
  Esaki M., Takemura G., Kosai K., Takahashi T., et.al.
- Journal Title
  
  Am J Physiol : Heart and Circulatory Physiology 294(2)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790547
[Journal Article] In vivo hepatocyte growth factor gene transfer reduces myocardial ischemiareperfusion injury through its multiple actions.2007
- Author(s)
  Chen XH, Minatoguchi S, Kosai K, Yuge K, Takahashi T, Arai M, Wang N, Misao Y, Lu C, Onogi H, Kobayashi H, Yasuda S, Ezaki M, Ushikoshi H, Takemura G, Fujiwara T, Fujiwara H.
- Journal Title
  
  J Card Fail. 13(10)
  
  Pages: 874-883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390286
[Journal Article] In vivo hepatocyte growth factor factor gene transfer reduces myocardial sichemia-reperfusi on injury through its multiple actions2007
- Author(s)
  Chen XH., Minatogichi S., Kosai K., Yuge K., Takahashi T., et. al.
- Journal Title
  
  J Card Fail. 13(10)
  
  Pages: 874-883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790547
[Journal Article] In vivo hepatocyte growth factor gene transfer reduces myocardial ischemiareperfusion injury through its multiple actions.2007
- Author(s)
  Chen XH., Minatogichi S., Kosai K., Yuge K., Takahashi T., Arai M., Wang N., Misao Y., Lu. C., Onogi H., Kobayashi H., Yasuda S., Ezaki M., Ushikoshi H., Takemura G., Fujiwara T., Fujiwara H.
- Journal Title
  
  J Card Fail. 13(10)
  
  Pages: 874-883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790547
[Journal Article] Identification and isolation of embryonic stem cell-derived target cells by adenoviral conditional targeting.2006
- Author(s)
  Takahashi T
- Journal Title
  
  Molecular Therapy 14(5)
  
  Pages: 673-683
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591126
[Journal Article] Identification and isolation of embryonic stem cell-derived target cells by adenoviral conditional targeting.2006
- Author(s)
  Takahashi T
- Journal Title
  
  Melecular Therapy 14・5
  
  Pages: 673-683
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591126
[Journal Article] "3.ES細胞と遺伝子治療技術"特集:I.ヒトおよびサルのES細胞2006
- Author(s)
  高橋知之
- Journal Title
  
  再生医療日本再生医療学会雑誌 5
  
  Pages: 61-69
- Data Source
  KAKENHI-PROJECT-17790509
[Journal Article] Identification and isolation of embryonic stem cell-derived target cells by adenoviral conditional targeting2006
- Author(s)
  Takahashi T., et al.
- Journal Title
  
  Mol. Ther. 14(5)
  
  Pages: 673-683
- Data Source
  KAKENHI-PROJECT-17790509
[Journal Article] Identification and isolation of embryonic stem cell-derived target cells by adenoviral conditional targeting.2006
- Author(s)
  Takahashi T
- Journal Title
  
  Molecular Therapy 14・5
  
  Pages: 673-683
- Data Source
  KAKENHI-PROJECT-17591126
[Journal Article] "3.ES細胞と遺伝子治療技術"特集 : I.ヒトおよびサルのES細胞2006
- Author(s)
  高橋知之, 他
- Journal Title
  
  再生医療日本再生医療学会雑誌 5(1)
  
  Pages: 43-51
- Data Source
  KAKENHI-PROJECT-17790509
[Journal Article] Postinfarction gene therapy against transforming growth factor-beta signal modulates infarct tissue dynamics and attenuates left ventricular remodeling and heart failure.2005
- Author(s)
  Okada-H, takemura-G, Kosai-K, Li-Y, Takahashi-T, et al.
- Journal Title
  
  Circulation 未定(in press)
- Data Source
  KAKENHI-PROJECT-15790380
[Journal Article] Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma.2005
- Author(s)
  Yuge-K, Takahashi-T, et al.
- Journal Title
  
  Int. J Oncol. 26(in press)
- Data Source
  KAKENHI-PROJECT-15790380
[Journal Article] "ES細胞の心筋分化と再生医学への技術開発"幹細胞生物学の新たな展開 -ES細胞の分化-2005
- Author(s)
  高橋知之
- Journal Title
  
  最新医学 60
  
  Pages: 1688-1694
- Data Source
  KAKENHI-PROJECT-17790509
[Journal Article] ES細胞の心筋分化と再生医学への技術開発. ES細胞の分化.「幹細胞生物学の新たな展開」2005
- Author(s)
  高橋知之
- Journal Title
  
  最新医学 60
  
  Pages: 28-34
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591126
[Journal Article] Efficient cardiomyogenic differentiation of embryonic stem cell by fibroblast growth facfor 2 and bone morphogenelic factor 2.2004
- Author(s)
  Kawai-T, Takahashi-T, et al.
- Journal Title
  
  Circ. J. 68
  
  Pages: 691-702
- Data Source
  KAKENHI-PROJECT-15790380
[Journal Article] Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction grantlocyte colony-stimulating factor treatment.2004
- Author(s)
  Minatoguchi-S, Takamura-G, Takahashi-T, et al.
- Journal Title
  
  Circulation 109
  
  Pages: 2572-2580
- Data Source
  KAKENHI-PROJECT-15790380
[Journal Article] Critical Roles for the Fas/Fas Ligand System in Postinfarction Ventricular Remodeling and Heart Failure.2004
- Author(s)
  Li-Y, Takemura-G, Kosai-K, Takahashi-T, et al.
- Journal Title
  
  Circ. Res. 95
  
  Pages: 627-636
- Data Source
  KAKENHI-PROJECT-15790380
[Journal Article] A definitive role of RhoC in metastasis of orthotopic lung cancer in mice.2004
- Author(s)
  Ikoma-T, Takahashi-T, et al.
- Journal Title
  
  Clin Cancer Res. 10
  
  Pages: 1192-1200
- Data Source
  KAKENHI-PROJECT-15790380
[Journal Article] Molecular Mechanisms of Non-apoptosis by Fas Stimulation Alone versus Apoptosis with an Additional Actinomycin D in Cultured Cardiomyocytes.2002
- Author(s)
  Aoyama, T., Takemura, G., Maruyama, R., Kosai, K., Takahashi, T., et ai.
- Journal Title
  
  Cardiovasc Res. 55
  
  Pages: 787-798
- Data Source
  KAKENHI-PROJECT-13770348
[Journal Article] Functional Involvemnt of LIM-kinases in Progeression of Oocyte Maturation.2001
- Author(s)
  Takahashi, T., Koshimizu, U., Abe, H., Obinata, T., Nak.amura, T.
- Journal Title
  
  Dev.Biol. 229
  
  Pages: 554-567
- Data Source
  KAKENHI-PROJECT-13770348
[Journal Article] Molecular Cloning and Characterization of Kremen, a Novel Kringle-containing Transmembrane Protein.2001
- Author(s)
  Nakamura, T., Aoki, S., Kitajima, K., Takahashi, T., et al.
- Journal Title
  
  Biochimca et Biophysics Acta 1518
  
  Pages: 63-72
- Data Source
  KAKENHI-PROJECT-13770348
[Journal Article] Increased plasma type B natriuretic peptide in the acute phase of Kawasaki disease.
- Author(s)
  Kishimoto S, Suda K, Teramachi Y, Nishino H, Kudo Y, Ishii H, Iemura M, Takahashi T, Okamura H, Matsuishi T.
- Journal Title
  
  Pediatr Int (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591291
[Patent] 高アンモニア血症を治療するための医薬組成物2019
- Inventor(s)
  芳野信、高橋知之、福井香織、石原直忠、長嶋比呂志
- Industrial Property Rights Holder
  芳野信、高橋知之、福井香織、石原直忠、長嶋比呂志
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-16K10002
[Patent] 高アンモニア血症を治療するための医薬組成物2019
- Inventor(s)
  芳野信、高橋知之、福井香織、石原直忠、長嶋比呂志
- Industrial Property Rights Holder
  芳野信、高橋知之、福井香織、石原直忠、長嶋比呂志
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-16K10002
[Patent] ヒトES/iPS細胞における遺伝子発現方法2012
- Inventor(s)
  小戝健一郎、三井薫、高橋知之
- Industrial Property Rights Holder
  小戝健一郎、三井薫、高橋知之
- Industrial Property Number
  2012-117128
- Filing Date
  2012-05-23
- Data Source
  KAKENHI-PROJECT-22591144
[Patent] ヒトＥＳ／ｉＰＳ細胞における遺伝子発現方法2012
- Inventor(s)
  小戝健一郎、三井薫、高橋知之
- Industrial Property Rights Holder
  小戝健一郎、三井薫、高橋知之
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-117128
- Filing Date
  2012-05-23
- Data Source
  KAKENHI-PROJECT-22591144
[Patent] 胚性幹細胞から分化した目的細胞の選別的単離又は可視化方法及び単離又は可視化用キット2010
- Inventor(s)
  小戝健一郎、高橋知之
- Industrial Property Rights Holder
  小戝健一郎
- Acquisition Date
  2010-11-12
- Data Source
  KAKENHI-PROJECT-19390286
[Patent] ヘパリン結合性上皮増殖因子様増殖因子の新規医薬用途2005
- Inventor(s)
  小戝健一郎, ニン・チン・カイ, 高橋知之
- Industrial Property Rights Holder
  久留米大学
- Industrial Property Number
  2005-283085
- Filing Date
  2005-09-28
- Data Source
  KAKENHI-PROJECT-17790509
[Patent] ヘパリン結合性上皮増殖因子様増殖因子の新規医薬用途
- Inventor(s)
  小戝健一郎, ニンチンカイ, 高橋知之
- Industrial Property Rights Holder
  久留米大学
- Industrial Property Number
  2005-283085
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591126
[Presentation] Moving towards a novel therapeutic strategy for hyperammonemia that targets glutamine metabolism2023
- Author(s)
  Fukui K, Takahashi T, Matsunari H, Uchikura A, Watanabe M, Nagashima H, Kakuma T, Watanabe Y, Yamashita Y, Yoshino M
- Organizer
  6th Asian Congress on Inherited Metabolic Diseases
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07811
[Presentation] レット症候群モデルマウスにおける睡眠・覚醒病態とオレキシンシグナル伝達の異常2022
- Author(s)
  弓削康太郎、高橋知之、河原幸江、坂井勇介、佐藤貴弘、児島将康、西昭徳、松石豊次郎、山下裕史朗
- Organizer
  第49回日本脳科学学会
- Data Source
  KAKENHI-PROJECT-18K07893
[Presentation] グルタミノリシスを標的とする高アンモニア血症の新規治療戦略2022
- Author(s)
  福井香織、高橋知之、松成ひとみ、内倉鮎子、渡邊將人、長嶋比呂志、石原直忠、角間辰之、山下裕史朗、渡邊順子、芳野信
- Organizer
  125回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08198
[Presentation] グルタミノリシスを標的とする高アンモニア血症の新規治療戦略2022
- Author(s)
  福井香織、高橋知之、松成ひとみ、内倉鮎子、渡邊将人、長嶋比呂志、石原直忠、角間辰之、渡邊順子、山下裕史朗、芳野　信
- Organizer
  第125回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07811
[Presentation] A novel therapeutic strategy for hyperammonemia that targets glutaminolysis2022
- Author(s)
  Fukui K, Takahashi T, Matsunari H, Uchikura A, Watanabe M, Nagashima H,3 Ishihara N, Kakuma T, Watanabe Y, Yamashita Y, Yoshino M
- Organizer
  The 125 Annual Meeting of the Japan Pediatric Society
- Data Source
  KAKENHI-PROJECT-21K07811
[Presentation] Study of Sleep Disturbances In Rett Syndrome By Mecp2-Deficient Mice2022
- Author(s)
  Kotaro Yuge, Munetsugu Hara, Tomoyuki Takahashi, Toyojiro Matsuishi, Yushiro Yamashita
- Organizer
  17th International child Neurology Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08198
[Presentation] MeCP2欠損マウスによるレット症候群の睡眠障害に関する研究2021
- Author(s)
  弓削康太郎、高橋知之、松石豊次郎、山下裕史朗
- Organizer
  第63回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08198
[Presentation] MeCP2欠損マウスによるレット症候群の睡眠障害に関する研究2021
- Author(s)
  弓削康太郎、高橋知之、松石豊次郎、山下裕史朗
- Organizer
  第63回日本小児神経学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07893
[Presentation] ジメチルα-ケトグルタル酸はグルタミン酸デヒドロゲナーゼのフラックス抑制によりアンモニアを低下させる2021
- Author(s)
  福井香織、高橋知之、渡邊順子、芳野信
- Organizer
  第62回日本先天代謝異常学会総会
- Data Source
  KAKENHI-PROJECT-20K08198
[Presentation] レット症候群モデルマウスを用いた病態解明と治療応用への展望2021
- Author(s)
  高橋知之
- Organizer
  第63回日本小児神経学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K08198
[Presentation] ジメチルα-ケトグルタル酸はグルタミン酸デヒドロゲナーゼのフラックス抑制によりアンモニアを低下させる2021
- Author(s)
  福井香織、高橋知之、渡邊順子、芳野　信
- Organizer
  第62回日本先天代謝異常学会
- Data Source
  KAKENHI-PROJECT-21K07811
[Presentation] A NOVEL THERAPEUTIC STRATEGY FOR HYPERAMMONEMIA TARGETING GLUTAMINOLYSIS2021
- Author(s)
  福井香織、高橋知之、松成ひとみ、内倉鮎子、長嶋比呂志、石原直忠、角間辰之、山下裕史朗、渡邊順子、芳野信
- Organizer
  5th International Symposium on Urea Cycle Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08198
[Presentation] A novel therapeutic strategy for hyperammonemia that targets glutaminolysis2021
- Author(s)
  Fukui K, Takahashi T, Matsunari H, Uchikura A, Watanabe M, Nagashima H, Ishihara N, Kakuma T, Watanabe Y, Yamashita Y, Yoshino M.
- Organizer
  5th International Symposium on Urea Cycle Disorders
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07811
[Presentation] レット症候群のジストニアにグレリンは有効か？2019
- Author(s)
  松石豊次郎、弓削康太郎、織本健司、高橋知之、池田恭
- Organizer
  第 34 回日本大脳基底核研究会
- Data Source
  KAKENHI-PROJECT-16K10002
[Presentation] 高アンモニア血症の新規治療法の開発2019
- Author(s)
  芳野信、高橋知之、福井香織、渡邊順子、石原直忠、松成ひとみ、板倉鮎子、長嶋比呂志
- Organizer
  第1回ファーマラボEXPO
- Data Source
  KAKENHI-PROJECT-16K10002
[Presentation] レット症候のジストニアにグレリンは有効か？-多施設共同研究を目指した評価指標の検討と問題点-2019
- Author(s)
  松石豊次郎、弓削康太郎、織本健司、高橋知之、池田恭
- Organizer
  第34回日本大脳基底核研究会
- Data Source
  KAKENHI-PROJECT-18K07893
[Presentation] A novel therapeutic strategy for hyperammonemia2019
- Author(s)
  Kaori Fukui, Tomoyuki Takahashi, Yoriko Watanabe, Yushiro Yamashita, Naotada Ishihara, Hitomi Matsunari, Ayuko Uchikura, Hiroshi Nagashima and Makoto Yoshino
- Organizer
  第61回日本先天代謝異常学会総会
- Data Source
  KAKENHI-PROJECT-16K10002
[Presentation] グレリンによるレット症候群の新規治療法の開発2018
- Author(s)
  松石豊次郎、弓削康太郎、高橋知之、永光信一郎、山下裕史朗
- Organizer
  第60回日本小児神経学会学術集会
- Data Source
  KAKENHI-PROJECT-16K10002
[Presentation] Lung abnormalities in Mecp2-null mouse model of Rett syndrome2017
- Author(s)
  Kida H., Takahashi T., Nakamura Y., Kinoshita T., Okayama S., Nakamura K., Taniwaki T., Yamashita Y., Matsuishi T.
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10002
[Presentation] Pathogenesis of Lung Injury in Mecp2-null Mouse Model for Rett Syndrome2017
- Author(s)
  貴田浩志、高橋知之、中村祐樹、木下隆、岡山聡子、中村桂一郎、小戝健一郎、谷脇考恭、山下裕史朗、松石豊次郎
- Organizer
  Conbio2017生命科学系学会合同年次大会（第90回日本生化学会大会）
- Data Source
  KAKENHI-PROJECT-16K10002
[Presentation] Pathogenesis of lung injury in Mecp2-null mouse model for Rett syndrome2017
- Author(s)
  ４．Kida H, Takahashi T, Nakamura Y, Ninoshita T, Okayama S, Nakamura K, Kosai K, Taniwaki T, Yamashita Y, Matsuishi T
- Organizer
  ConBio 2017 生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K09608
[Presentation] Analysis of cardic arrhythmias and gene expression in MeCP2-null mouse2014
- Author(s)
  4)Hara M, Takahashi T, Mitsumasu C, Igata S, Takano M, Okabe,Y, Tanaka E, Matsuishi T
- Organizer
  13th Rett syndrome Symposium
- Place of Presentation
  Chantilly, Washington, USA
- Year and Date
  2014-06-19
- Data Source
  KAKENHI-PROJECT-24591531
[Presentation] アデノウイルスベクターでのヒト多能性幹細胞への高効率遺伝子導入技術の開発2014
- Author(s)
  三井薫、高橋知之、井手佳菜子、小戝健一郎
- Organizer
  第13回日本再生医療学会総会
- Place of Presentation
  国立京都国際会館（京都）
- Data Source
  KAKENHI-PROJECT-25461568
[Presentation] ヒトES/iPS細胞での再生医療の課題を克服する独自のアデノウイルスベクターと発現技術の開発2012
- Author(s)
  小戝健一郎、三井薫、王宇清、高橋知之
- Organizer
  第11回日本再生医療学会総会
- Place of Presentation
  横浜、日本
- Data Source
  KAKENHI-PROJECT-22591144
[Presentation] ヒトES/iPS細胞での再生医療の課題を克服する独自のアデノウイルスベクターと発現技術の開発2012
- Author(s)
  小戝健一郎、三井薫、王宇清、高橋知之
- Organizer
  第11回日本再生医療学会総会(横浜)
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-22591144
[Presentation] 再生医療技術によるモデル細胞の樹立と神経分化2011
- Author(s)
  高橋知之
- Organizer
  第53回日本小児神経学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PROJECT-22591144
[Presentation] MeCP2遺伝子欠損ES細胞のin vitro分化誘導法によるRett症候群/神経発生の研究システム2011
- Author(s)
  小戝健一郎、高橋知之, その他
- Organizer
  第10回日本再生医療学会総会
- Place of Presentation
  横浜
- Year and Date
  2011-03-02
- Data Source
  KAKENHI-PROJECT-22591144
[Presentation] MeCP2遺伝子欠損ES細胞のin vitro分化誘導法によるRett症候群/神経発生の研究システム2011
- Author(s)
  小戝健一郎、岡部恭典、久佐賀晃、高橋知之、光益千秋、村井恵良、松石豊次郎、田中永一郎
- Organizer
  第10回日本再生医療学会総会(横浜)
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-03-02
- Data Source
  KAKENHI-PROJECT-22591144
[Presentation] RTTモデルES細胞由来神経細胞の電気生理学的解析2011
- Author(s)
  岡部恭典、久佐賀晃、高橋知之、光益千秋、村井恵良、東英穂、松石豊次郎、小戝健一郎、田中永一郎
- Organizer
  第88回日本生理学会大会
- Place of Presentation
  横浜
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-22591144
[Presentation] Involvement of myeloid dendritic cell in the pathogenesis of acute phase of Kawasaki disease.2010
- Author(s)
  Suda K, Kishimoto S , Takahashi T, Okamura H, Yasukawa H, Nishino H, Teramachi Y, Itoh S , Yokoyama T, Iemura M, Imaizumi T, Matsuishi T.
- Organizer
  The 74^<th> annual scientific meeting of the Japanese Circulation Society.
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20591291
[Presentation] 川崎病急性期における末梢血樹状細胞数に関与するサイトカイン、ケモカイン2010
- Author(s)
  須田憲治,岸本慎太郎,高橋知之,岡本尚昌,横山隆人,寺町陽三,工藤嘉公,家村素史,松石豊次郎
- Organizer
  第30回日本川崎病学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591291
[Presentation] 川崎病急性期における末梢血樹状細胞数に関与するサイトカイン、ケモカイン"Change in Chemokines associated with the number of circulating dendritic cells in acute phase of Kawasaki disease2010
- Author(s)
  須田憲治、岸本慎太郎、高橋知之、岡村尚昌、横山隆人、寺町陽三、工藤嘉公、家村素史、松石豊次郎
- Organizer
  第30回日本川崎病学会学術集会(京都)
- Place of Presentation
  国立京都国際会館
- Year and Date
  2010-10-22
- Data Source
  KAKENHI-PROJECT-22591144
[Presentation] 川崎病急性期における末梢血樹状細胞数に関与するサイトカイン、ケモカイン.2010
- Author(s)
  須田憲治、岸本慎太郎, 高橋知之, 他
- Organizer
  第30回日本川崎病学会・学術集会
- Place of Presentation
  京都
- Year and Date
  2010-10-10
- Data Source
  KAKENHI-PROJECT-20591291
[Presentation] Involvement of myeloid dendritic cell in the pathogenesis of acute phase of Kawasaki disease.2010
- Author(s)
  SudaK,Kishimoto S, Takahashi T,Okamura H, Yasukawa H, Nishino H, Teramachi Y, Itoh S, Yokoyama T, Iemura M, Imaizumi T, MatsushiT.
- Organizer
  The 74th annual scientific meeting of the Japanese Circulation Society
- Place of Presentation
  Kyoto,Japan
- Data Source
  KAKENHI-PROJECT-22591144
[Presentation] Involvement of myeloid dendritic cell in the pathogenesis of acutephase of Kawasaki Disease2010
- Author(s)
  Suda K, Kishimoto S, Takahashi T, Okamura H, Yasukawa T, Nishino H, Teramachi Y, Yokoyama T, Iemura M, Imaizumi T, Matsuishi T
- Organizer
  第74回日本循環器学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20591291
[Presentation] 川崎病急性期における流血中の樹状細胞の動態2009
- Author(s)
  須田憲治,岸本慎太郎,西野裕,高橋知之,岡村尚昌,安川秀雄,伊藤晋一,横山隆人,家村素史,松石豊次郎
- Organizer
  第112回日本小児科学会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-20591291
[Presentation] Involvement of myeloid dendritic cell in the pathophysiology of acute phase of Kawasaki disease.2009
- Author(s)
  Suda K, Kishimoto S, Takahashi T, Okamura H, Yasukawa H, Nishino H, Yokoyama T, Iemura M, Matsuishi T.
- Organizer
  American Heart Association 2009
- Place of Presentation
  Orlando, America
- Data Source
  KAKENHI-PROJECT-20591291
[Presentation] Involvement of myeloid dendritic cell in the pathogenesis of acute phase of Kawasaki disease2009
- Author(s)
  須田憲治, 岸本慎太郎, 高橋知之, et al.
- Organizer
  American Heart Association 2009
- Place of Presentation
  Orlando, FL, USA
- Data Source
  KAKENHI-PROJECT-20591291
[Presentation] 急性期川崎病患者の末梢血中の樹状細胞動態2009
- Author(s)
  須田憲治,岸本慎太郎,高橋知之,岡村尚昌,寺町陽三,西野裕,横山隆人,籠手田雄介,家村素史,松石豊次郎
- Organizer
  第29回日本川崎病学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20591291
[Presentation] 川崎病急性期における流血中の樹状細胞の動態2008
- Author(s)
  須田憲治,安川秀雄,高橋知之,岡村尚昌,西野裕,横山隆人,工藤嘉公,石井治佳,家村素史,松石豊次郎
- Organizer
  第28回日本川崎病研究会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20591291
[Presentation] 川崎病急性期における流血中の樹状細胞の動態Significant decrease of circulating myeloid dendritic cells in acute phase of Kawasaki disease2008
- Author(s)
  須田憲治、安川秀雄、高橋知之、岡村尚昌、西野裕、横山隆人、工藤嘉公、石井治佳、家村素史、松石豊次郎
- Organizer
  第28回日本川崎病研究会
- Place of Presentation
  札幌医科大学
- Data Source
  KAKENHI-PROJECT-19790547
[Presentation] Conditionally Replicating Adenovirus Regulated by Survivin and CEA Promoters Exerted More Strict Cancer Specificity and Potent Anti-Cancer Effect.2007
- Author(s)
  Yoshiteru Murofushi, Junichi Kamizono, Ngin Cin Khai, Tomoyuki Takahashi, Setsuro Komiya, Ken-ichiro Kosai.
- Organizer
  第13回日本遺伝子治療学会
- Place of Presentation
  名古屋市(愛知がんセンター)
- Data Source
  KAKENHI-PROJECT-19390286
[Presentation] Conditional replicating adenovirus regulated by SURVIVIN and CER promoters exerted more strict cancer specificity and potent anti-cancer effect2007
- Author(s)
  Murofushi Y., Kamizono J., Khai NC., Takahashi T., Komiya S.,and Kosai K.
- Organizer
  Japan Society of Gene Therapy The 13th Annual Meeting
- Place of Presentation
  International Conference Hall (Aichi Cancer Center)
- Data Source
  KAKENHI-PROJECT-19790547
[Presentation] Survivin-Responsive Conditionally Replicating Adenovirus Additionally Regulated with Cancer Specificity without Reducing Anti-Cabcer Effect.2007
- Author(s)
  Yoshiteru Murofushi, Junichi Kamizono, Ngin Cin Khai, Tomoyuki Takahashi, Setsuro Komiya, Ken-ichiro Kosai.
- Organizer
  The 10th Annual Meeting of the American Society of Gene Therapy
- Place of Presentation
  Seattle, Washington, USA
- Year and Date
  2007-06-01
- Data Source
  KAKENHI-PROJECT-19390286
[Presentation] Neural development of MeCP2 null embryonic stem cells.
- Author(s)
  Okabe Y, Takahashi T, Tanaka E, Matsuishi T.
- Organizer
  RETT syndrome Symposium in Fukuoka
- Place of Presentation
  ホテルオークラ福岡
- Data Source
  KAKENHI-PROJECT-24591531
[Presentation] Analysis of cardiac arrthymias and gene expression in MeCP2-null mice
- Author(s)
  Hara M, Takahashi T, Mitsumasu C, Igata S, Takano M, Okabe Y, Tanaka E, Matsuishi T.
- Organizer
  13th Rett syndrome Symposium
- Place of Presentation
  Chantilly, VA, USA.
- Year and Date
  2014-06-24 – 2014-06-26
- Data Source
  KAKENHI-PROJECT-25461568
[Presentation] MeCP2遺伝子変異をもつレット症候群患者の血漿中グレリン濃度の検討
- Author(s)
  原宗嗣、葉純子、西芳寛、高橋　悟、山下裕史朗、田中永一郎、児島将康、松石豊次郎
- Organizer
  第54回日本小児神経学会総会
- Place of Presentation
  ロイトン札幌
- Data Source
  KAKENHI-PROJECT-24591531
[]

1. MATSUISHI Toyojiro (60157237)

# of Collaborated Projects: 7 results

# of Collaborated Products: 22 results
2. YAMASHITA Yusihro (90211630)

# of Collaborated Projects: 5 results

# of Collaborated Products: 7 results
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# of Collaborated Projects: 4 results

# of Collaborated Products: 11 results
4. NISHI Yoshihiro (20352122)

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10. OKABE Yasunori (00446098)

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11. KOJIMA Masayasu (20202062)

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13. Yuge Kotarou (20624472)

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18. MURAI Yoshinaka (40322820)

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19. KANAMORI Hiromitsu (20456502)

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20. MATSUMOTO Naomichi (80325638)

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21. TSUCHIYA Kunihiko (30313878)

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22. MAENO Yasuki (90248401)

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23. 小宮節郎 (30178371)

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24. 河野嘉文 (20260680)

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25. 前薗理恵 (90381178)

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26. 室伏善照 (50448578)

# of Collaborated Projects: 1 results

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27. 江良択実 (00273706)

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28. 佐藤貴弘 (50368883)

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30. 瀬戸口修一 (80826032)

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31. 高田二郎 (90122704)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 原宗嗣 (30389283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 西小森隆太 (70359800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 粟屋智就 (20589593)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. KUDO Yoshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 青天目信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 谷脇考恭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 三井薫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 八木田和弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 土谷佳樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takahashi Tomoyuki 高橋 知之

TAKAHASHI Tomoyuki 高橋 知之

高橋 智之 タカハシ トモユキ

高橋 和之 タカハシ カズユキ

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Analysis of developmental disorder phenotypes in mouse models of Rett Syndrome for drug discoveryPrincipal Investigator

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Analysis of sleep disorder phenotypes in mouse models of Rett Syndrome for drug discoveryPrincipal Investigator

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Development of innovative therapies for Rett syndrome with cell transplantation and functions control of microgliaPrincipal Investigator

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Glial cells differentiation of MeCP2 deficient ES/iPS cells and pathophysiology of Rett syndromePrincipal Investigator

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Generation of iPS cells derived form an Rett syndrome model mouse and drug screening for Rett syndrome using MeCP2 deficient iPS cellsPrincipal Investigator

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Takahashi Tomoyuki 高橋知之

TAKAHASHI Tomoyuki 高橋知之

高橋智之タカハシトモユキ

高橋和之タカハシカズユキ