HARADA Michsihige 原田通成

… Alternative Names

原田通成ハラダミチシゲ

HARADA Michishige 原田通成

Less

Researcher Number	20333487
External Links
Affiliation (Current)	2025: 国立研究開発法人理化学研究所, 生命医科学研究センター, 技師
Affiliation (based on the past Project Information) *help	2015: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 研究員 2013 – 2014: 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 2009 – 2012: The Institute of Physical and Chemical Research, 免疫制御研究グループ, 研究員 2005 – 2006: 独立行政法人理化学研究所, アレルギー体質関連遺伝子研究チーム, 研究員 2004: RIKEN, Laboratory for Immune Regulation, Scientist, 免疫制御研究グループ, 研究員 2003: 独立行政法人理化学研究所, 免疫制御研究チーム, 研究員
Review Section/Research Field	Principal Investigator Immunology / 膠原病・アレルギー・感染症内科学 Except Principal Investigator Immunology / Immunology
Keywords	Principal Investigator NKT細胞 / アレルギー疾患 / 重症度 / 相関解析 / 気管支喘息 / SNPs / アレルギー・ぜんそく / ウイルス / 呼吸機能 / 薬理遺伝学 … More / 気道上皮細胞 / ウイルス感染刺激 / 遺伝子多型 / TSLP / アポトーシス / BCGワクチン / IL-12 / 衛生仮説 / BCG / IgE / IL-21 / アレルギー / 免疫 / 抑制性受容体 / Inhibitory receptor / 細胞傷害 / SHP-1 / ITIM / CD1d … More Except Principal Investigator α-galactosylceramide / IL-4 / NKT細胞 / IFN-γ / V α 14 NKT cells / NKT細胞特異的遺伝子 / α-ガラクトシルセラミド / 臓器移植生着 / 自己免疫疾患 / 分化 / サブトラクション / BCG / IgE抗原産生制御 / DNAチップ / Cタイプレクシン / 免疫制御 / アポトーシス / 同種骨髄移植 / 自然免疫系 / 新規NK受容体 / 抑制性NK受容体NKG2I / 制御性樹状細胞 / IL-10 / Vα14 / インターフェロン-γ / Vα14NTK細胞 / レンチウイルベクター / shRNA / Vα14Jα18受容体遺伝子 / 機能分化 / 発生分化 / high throughput RT-qPCR / サイトカイン産生 / リンパ球分化 / RNA-sequence / 単一細胞PCR / iPS / NKT細胞前駆細胞 / エピジェネティック制御 / 分化経路 / 転写因子 / 肝臓 NKT細胞 / Th1関連遺伝子 / NKT細胞分化新規経路 / エピゲノム解析 / NKT細胞新規分化経路 / NKT細胞特異的転写因子 / NKT細胞サブタイプ Less

The mechanisms of development and differentiation in Valpha14 NKT cells
- Principal Investigator
  
  Taniguchi Masaru
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  Institute of Physical and Chemical Research
Functional SNPs in TSLP gene is associated with susceptibility to asthmaPrincipal Investigator
- Principal Investigator
  
  HARADA Michsihige
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  The Institute of Physical and Chemical Research
Vα14NKT細胞の産生するIL-21を介したIgE調節機構の解明Principal Investigator
- Principal Investigator
  
  原田通成
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research
VαNKT細胞に発現するCD1d分子を認識する抑制性受容体の細胞傷害抑制機構Principal Investigator
- Principal Investigator
  
  原田通成
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  The Institute of Physical and Chemical Research
Molecular mechanisms of NKT cells' differentiation and functions
- Principal Investigator
  
  TANIGUCHI Masaru
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Immunology
- Research Institution
  RIKEN
  Chiba University

All 2016 2015 2011 2010 2009 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Patent

[Journal Article] Generation of Novel Traj18-Deficient Mice Lacking Vα14 Natural Killer T Cells with an Undisturbed T Cell Receptor α-Chain Repertoire.2016
- Author(s)
  Dashtsoodol N, Shigeura T, Ozawa R, Harada M, Kojo S, Watanabe T, Koseki H, Nakayama M, Ohara O, Taniguchi M.
- Journal Title
  
  PLoS ONE
  
  Volume: 11 Issue: 4 Pages: 1-10
- DOI
  10.1371/journal.pone.0153347
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08291, KAKENHI-PROJECT-23229005, KAKENHI-PROJECT-24790490
[Journal Article] Discovery of NKT cells and development of NKT cell-targeted anti-tumor immunotherapy2015
- Author(s)
  Taniguchi M, Harada M, Dashtsoodol N, Kojo S.
- Journal Title
  
  Proceedings of the Japan Academy, Series B
  
  Volume: 91 Issue: 7 Pages: 292-304
- DOI
  10.2183/pjab.91.292
- NAID
  130005088948
- ISSN
  0386-2208, 1349-2896
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08291, KAKENHI-PROJECT-23229005, KAKENHI-PROJECT-24790490
[Journal Article] Discovery of NKT cells and development of NKT cell-targeted anti-tumor2015
- Author(s)
  Taniguchi M, Harada M, Nyambayar D, Kojo S
- Journal Title
  
  The Proceedings of the Japan Academy Series B
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23229005
[Journal Article] Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma2011
- Author(s)
  Harada M, Hirota T, Jodo Al, et al
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 44 Issue: 6 Pages: 787-793
- DOI
  10.1165/rcmb.2009-0418oc
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591290, KAKENHI-PROJECT-22590834, KAKENHI-PROJECT-23791204, KAKENHI-PROJECT-21390303
[Journal Article] TSLP Promoter Polymorphisms are Associated with Susceptibility to Bronchial Asthma2011
- Author(s)
  Harada M, Hirota T, Jodo AI, Doi S, Kameda M, Fujita K, Miyatake A, Enomoto T, Noguchi E, Yoshihara S, Ebisawa M, Saito H, Matsumoto K, Nakamura Y, Ziegler SF, Tamari M
- Journal Title
  
  Am J Respir Cell Mol Biol
  
  Volume: 44 Pages: 787-793
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591290
[Journal Article] 気管支喘息と自然免疫関連遺伝子2010
- Author(s)
  原田通成,広田朝光,玉利真由美
- Journal Title
  
  感染・炎症・免疫
  
  Volume: 39 Pages: 364-366
- Data Source
  KAKENHI-PROJECT-21591290
[Journal Article] アレルギーの遺伝要因:自然免疫応答の関与2010
- Author(s)
  原田通成,広田朝光,人見祐基,玉利真由美
- Journal Title
  
  実験医学
  
  Volume: 27 Pages: 3360-3365
- Data Source
  KAKENHI-PROJECT-21591290
[Journal Article] 遺伝子多型とアレルギー疾患2010
- Author(s)
  原田通成,広田朝光,玉利真由美、人見祐基
- Journal Title
  
  アレルギーの臨床
  
  Volume: 30 Pages: 164-167
- Data Source
  KAKENHI-PROJECT-21591290
[Journal Article] A functional polymorphism in IL-18 is associated with severity of bronchial asthma2009
- Author(s)
  Michishige Harada, et al.
- Journal Title
  
  American Journal of Respiratory Critical Care Medic 180
  
  Pages: 1048-1055
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591290
[Journal Article] 小児気管支喘息と遺伝子多型2009
- Author(s)
  原田通成,広田朝光,人見祐基,玉利真由美
- Journal Title
  
  喘息
  
  Volume: 22 Pages: 154-158
- Data Source
  KAKENHI-PROJECT-21591290
[Journal Article] Functional Polymorphism in the Suppressor of Cytokine Signaling 1 Gene Associated With Adult Asthma.2007
- Author(s)
  Harada, M. et al.
- Journal Title
  
  Am J Respir Cell Mol Biol. (In press)
- Data Source
  KAKENHI-PROJECT-17790331
[Journal Article] IL-21-induced Bε cell apoptosis mediated by natural killer T cells suppresses IgE responses.2006
- Author(s)
  Harada, M. et al.
- Journal Title
  
  J Exp Med 203・13
  
  Pages: 2929-2937
- Data Source
  KAKENHI-PROJECT-17790331
[Journal Article] Down-regulation of the invariant Vα14 antigen receptor in NKT cells upon activation2004
- Author(s)
  Harada et al.
- Journal Title
  
  Int.Immunol 16
  
  Pages: 241-247
- NAID
  10013083361
- Data Source
  KAKENHI-PROJECT-15790259
[Journal Article] Down-regulation of invariant Vα14 antigen receptor in NKT cells upon activation2004
- Author(s)
  Harada M., et al.
- Journal Title
  
  Int.Immunol. 16
  
  Pages: 241-247
- NAID
  10013083361
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13307011
[Journal Article] Down-regulation of invariant Vα14 antigen receptor in NKT cells upon activation.2004
- Author(s)
  Harada M., et al.
- Journal Title
  
  Int.Immunol 16
  
  Pages: 241-247
- NAID
  10013083361
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13307011
[Journal Article] Vα14 NKT細胞と糖脂質2003
- Author(s)
  原田通成 et al.
- Journal Title
  
  蛋白質核酸酵素 48
  
  Pages: 1126-1132
- Data Source
  KAKENHI-PROJECT-15790259
[Journal Article] TSLP Promoter Polymorphisms are Associated with Susceptibility to Bronchial Asthma.
- Author(s)
  Michishige Harada, et al.
- Journal Title
  
  Am J Respir Cell Mol Biol.
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591290
[Patent] IL-21産生誘導剤2005
- Inventor(s)
  原田通成外2名
- Industrial Property Rights Holder
  理化学研究所
- Industrial Property Number
  2005-089683
- Filing Date
  2005-03-25
- Data Source
  KAKENHI-PROJECT-17790331
[Presentation] TSLPとアレルギー疾患2009
- Author(s)
  玉利真由美、原田通成、広田朝光、人見祐基
- Organizer
  第21回日本アレルギー学会春季臨床大会
- Place of Presentation
  岐阜
- Data Source
  KAKENHI-PROJECT-21591290
[Presentation] ジェノミクス各論-遺伝子多型を用いたアレルギー疾患の解析2009
- Author(s)
  原田通成、広田朝光、人見裕基、城道絢、玉利真由美
- Organizer
  第59回日本アレルギー学会秋期学術大会
- Place of Presentation
  秋田
- Data Source
  KAKENHI-PROJECT-21591290
[Presentation] ジェノミクス各論-遺伝子多型を用いたアレルギー疾患の解析2009
- Author(s)
  原田通成
- Organizer
  第59回日本アレルギー学会秋期学術大会
- Place of Presentation
  秋田
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-21591290

1. Taniguchi Masaru (80110310)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. TAMARI Mayumi (00217184)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. KOJO Satoshi (70360542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. OZAWA Ritsuko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HARADA Michsihige 原田 通成

原田 通成 ハラダ ミチシゲ

HARADA Michishige 原田 通成

Research Projects

Research Products

Co-Researchers

The mechanisms of development and differentiation in Valpha14 NKT cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional SNPs in TSLP gene is associated with susceptibility to asthmaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Vα14NKT細胞の産生するIL-21を介したIgE調節機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

VαNKT細胞に発現するCD1d分子を認識する抑制性受容体の細胞傷害抑制機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of NKT cells' differentiation and functions

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Generation of Novel Traj18-Deficient Mice Lacking Vα14 Natural Killer T Cells with an Undisturbed T Cell Receptor α-Chain Repertoire.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Discovery of NKT cells and development of NKT cell-targeted anti-tumor immunotherapy2015

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Discovery of NKT cells and development of NKT cell-targeted anti-tumor2015

Author(s)

Journal Title

Data Source

[Journal Article] Thymic stromal lymphopoietin gene promoter polymorphisms are associated with susceptibility to bronchial asthma2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TSLP Promoter Polymorphisms are Associated with Susceptibility to Bronchial Asthma2011

Author(s)

Journal Title

Data Source

[Journal Article] 気管支喘息と自然免疫関連遺伝子2010

Author(s)

Journal Title

Data Source

[Journal Article] アレルギーの遺伝要因:自然免疫応答の関与2010

Author(s)

Journal Title

Data Source

[Journal Article] 遺伝子多型とアレルギー疾患2010

Author(s)

Journal Title

Data Source

[Journal Article] A functional polymorphism in IL-18 is associated with severity of bronchial asthma2009

Author(s)

Journal Title

Data Source

[Journal Article] 小児気管支喘息と遺伝子多型2009

Author(s)

HARADA Michsihige 原田通成

原田通成ハラダミチシゲ

HARADA Michishige 原田通成

[Presentation] ジェノミクス各論-遺伝子多型を用いたアレルギー疾患の解析2009