Inuzuka Hiroyuki 犬塚博之

Researcher Number	20335863
Affiliation (based on the past Project Information) *help	2016 – 2023: 東北大学, 歯学研究科, 准教授 2016: 東北大学歯学研究科, 歯学部, 准教授
Review Section/Research Field	Principal Investigator Dental engineering/Regenerative dentistry / Basic Section 57040:Regenerative dentistry and dental engineering-related / Medium-sized Section 57:Oral science and related fields Except Principal Investigator Medium-sized Section 57:Oral science and related fields / Orthodontics/Pediatric dentistry / Tumor biology / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Dental engineering/Regenerative dentistry / Functional basic dentistry
Keywords	Principal Investigator 蛋白質分解 / タンパク質分解 / ユビキチン-プロテアソーム系 / 歯髄幹細胞 / 歯周組織再生 / Lipin / Lipin2 / マクロファージ / 炎症 / 神経成長因子 … More / p75NTR / エピゲノム修飾 / iPS 細胞 / iPS細胞 / iPS / iPS cells / Ubiquitination / SKP2 / SCF/beta-TRCP / 間葉系幹細胞 / beta-TRCP / Lipin1 / 脂質代謝 … More Except Principal Investigator 再生医療 / 幹細胞 / 唾液腺 / 毛 / 器官形成 / エナメル芽細胞 / 歯 / 骨代謝 / プロテアソーム / ユビキチン / シグナル伝達 / チロシンキナーゼ阻害薬 / β-catenin / 肺がん / 薬剤耐性 / EGFR / 肺癌 / チロシンキナーゼ / 器官再生 / 細胞転換 / 歯原性上皮細胞 / 歯胚 / 歯原性上皮 / 歯髄幹細胞 / 分化誘導 / タンパク質分解 / プロテインノックダウン / 細胞分化 / 発生・分化 / 歯学 / 再生医学 / 上皮陥入 / 遺伝子スクリーニング / 器官発生 / 石灰化 / エナメル質 / 再生歯学 / 歯の発生 / Osterix / 骨芽細胞 / 分子生物学 / 骨吸収 / ユビキチンー / 先天性疾患 / ユビキチン・プロテアソーム / 骨融解症 / Osteolysis / 破骨細胞 / Notch2 / FBW7 / Hajdu-Cheney症候群 / 増殖因子 / 細胞間結合 Less

Development of artificial epithelial cell induction technology as a cell resource for organ regeneration
- Principal Investigator
  
  Fukumoto Satoshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Kyushu University
歯周組織再生を目指した効率的な抗炎症療法の開発Principal Investigator
- Principal Investigator
  
  犬塚博之
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  Tohoku University
パーキンソン病-骨代謝連関制御と歯髄幹細胞を用いた再生へ向けた分子基盤の解明
- Principal Investigator
  
  福島秀文
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Tohoku University
Establishment of a method for improving the efficiency of stem cell differentiation using a protein knockdown strategy
- Principal Investigator
  
  Shimizu Kouhei
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Osaka City University
  Tohoku University
Molecular mechanisms of p75NTR modulation in the regeneration of pulp sensory functionPrincipal Investigator
- Principal Investigator
  
  Inuzuka Hiroyuki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Tohoku University
Identification of the mechanisms underlying tumorigenesis by oncogenic tyrosine kinases
- Principal Investigator
  
  Kobayashi Susumu
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan
Development of high predictive bone regeneration method applying quantitative control mechanism of osteoblast differentiation factor
- Principal Investigator
  
  福島秀文
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  Tohoku University
Elucidation of organ determination mechanism in epithelial / endothelial invaginated tissue
- Principal Investigator
  
  Fukumoto Satoshi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Kyushu University
  Tohoku University
Modulation of lipid homeostasis in maintenance and directed differentiation of mesenchymal stem cellsPrincipal Investigator
- Principal Investigator
  
  Inuzuka Hiroyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  Tohoku University
Analysis of growth factor - intercellular communication during dental epithelial and mesenchymal cell differentiation.
- Principal Investigator
  
  YAMADA AYA
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Orthodontics/Pediatric dentistry
- Research Institution
  Tohoku University
Identification of proteolytic signaling pathways regulating reprogramming during iPS cell generationPrincipal Investigator
- Principal Investigator
  
  Inuzuka Hiroyuki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  Tohoku University
Elucidation of pathological molecular mechanism of Notch2-Hajdu Cheney Syndrome type mutation
- Principal Investigator
  
  Hidefumi Fukushima
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional basic dentistry
- Research Institution
  Tohoku University
  Fukuoka Dental College

All 2021 2020 2019 2018 2017 2016 2014

All Journal Article Presentation

[Journal Article] Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages2021
- Author(s)
  Watahiki Asami、Hoshikawa Seira、Chiba Mitsuki、Egusa Hiroshi、Fukumoto Satoshi、Inuzuka Hiroyuki
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 6 Pages: 2893-2893
- DOI
  10.3390/ijms22062893
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03834, KAKENHI-PROJECT-20K23097
[Journal Article] Interplay between protein acetylation and ubiquitination controls MCL1 protein stability2021
- Author(s)
  Shimizu Kouhei、Gi Min、Suzuki Shugo、North Brian J.、Watahiki Asami、Fukumoto Satoshi、Asara John M.、Tokunaga Fuminori、Wei Wenyi、Inuzuka Hiroyuki
- Journal Title
  
  Cell Reports
  
  Volume: 37 Issue: 6 Pages: 109988-109988
- DOI
  10.1016/j.celrep.2021.109988
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16146, KAKENHI-PROJECT-18H02619, KAKENHI-PROJECT-21H02688, KAKENHI-PROJECT-20K20612, KAKENHI-PROJECT-16H06276
[Journal Article] Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy2020
- Author(s)
  Gao Y, Nihira NT, Bu X, Chu C, Zhang J, Kolodziejczyk A, Fan Y, Chan NT, Ma L, Liu J, Wang D, Dai X, Liu H, Ono M, Nakanishi A, Inuzuka H, North BJ, Huang YH, Sharma S, Geng Y, Xu W, Liu XS, Li L, Miki Y, Sicinski P, Freeman GJ, Wei W.
- Journal Title
  
  Nat Cell Biol.
  
  Volume: 22(9) Issue: 9 Pages: 1064-1075
- DOI
  10.1038/s41556-020-0562-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03497, KAKENHI-PROJECT-19H03834
[Journal Article] Lipin-2 degradation elicits a proinflammatory gene signature in macrophages2020
- Author(s)
  Watahiki Asami、Shimizu Kouhei、Hoshikawa Seira、Chiba Mitsuki、Kitamura Hiroshi、Egusa Hiroshi、Fukumoto Satoshi、Inuzuka Hiroyuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 524 Issue: 2 Pages: 477-483
- DOI
  10.1016/j.bbrc.2020.01.119
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03834, KAKENHI-PROJECT-19J11773, KAKENHI-PROJECT-18K19282, KAKENHI-PROJECT-18K19632, KAKENHI-PROJECT-18K06035
[Journal Article] Phosphorylation‐dependent osterix degradation negatively regulates osteoblast differentiation2020
- Author(s)
  Hoshikawa Seira、Shimizu Kouhei、Watahiki Asami、Chiba Mitsuki、Saito Kan、Wei Wenyi、Fukumoto Satoshi、Inuzuka Hiroyuki
- Journal Title
  
  The FASEB Journal
  
  Volume: 34 Issue: 11 Pages: 14930-14945
- DOI
  10.1096/fj.202001340r
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16146, KAKENHI-PROJECT-18H03009, KAKENHI-PROJECT-19H03834, KAKENHI-PROJECT-19J11773
[Journal Article] G protein coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts2020
- Author(s)
  Chiba Yuta、Yoshizaki Keigo、Saito Kan、Ikeuchi Tomoko、Iwamoto Tsutomu、Rhodes Craig、Nakamura Takashi、de Vega Susana、Morell Robert J.、Boger Erich T.、Martin Daniel、Hino Ryoko、Inuzuka Hiroyuki、Bleck Christopher K.E.、Yamada Aya、Yamada Yoshihiko、Fukumoto Satoshi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 45 Pages: 15328-15341
- DOI
  10.1074/jbc.ra120.014281
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K18747, KAKENHI-PROJECT-17H01606, KAKENHI-PROJECT-18H03009, KAKENHI-PROJECT-18H03012, KAKENHI-PROJECT-19H03834, KAKENHI-PROJECT-20K07429
[Journal Article] Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ2020
- Author(s)
  Saito K, Michon F, Yamada A, Inuzuka H, Yamaguchi S, Fukumoto E, Yoshizaki K, Nakamura T, Arakaki M, Chiba Y, Ishikawa M, Okano H, Thesleff I, Fukumoto S.
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 7 Pages: 101329-101329
- DOI
  10.1016/j.isci.2020.101329
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20612, KAKENHI-PROJECT-20K18747, KAKENHI-PROJECT-17H01606, KAKENHI-PROJECT-18H03009, KAKENHI-PROJECT-18H03012, KAKENHI-PROJECT-19H03834
[Journal Article] SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation2019
- Author(s)
  Ma Ying、Cui Danrui、Xiong Xiufang、Inuzuka Hiroyuki、Wei Wenyi、Sun Yi、North Brian J.、Zhao Yongchao
- Journal Title
  
  Molecular Oncology
  
  Volume: 13 Issue: 2 Pages: 307-321
- DOI
  10.1002/1878-0261.12403
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03834, KAKENHI-PROJECT-18K19632
[Journal Article] SCFβ-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation2018
- Author(s)
  Ci Yanpeng、Li Xiaoning、Chen Maorong、Zhong Jiateng、North Brian J.、Inuzuka Hiroyuki、He Xi、Li Yu、Guo Jianping、Dai Xiangpeng
- Journal Title
  
  Protein & Cell
  
  Volume: 9 Issue: 10 Pages: 879-889
- DOI
  10.1007/s13238-018-0510-2
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19632, KAKENHI-PROJECT-16H05529
[Journal Article] Physiological functions of FBW7 in cancer and metabolism2018
- Author(s)
  Shimizu Kouhei、Nihira Naoe Taira、Inuzuka Hiroyuki、Wei Wenyi
- Journal Title
  
  Cellular Signalling
  
  Volume: 46 Pages: 15-22
- DOI
  10.1016/j.cellsig.2018.02.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19282, KAKENHI-PROJECT-18K19632, KAKENHI-PROJECT-16H05529, KAKENHI-PROJECT-17H06531
[Journal Article] SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis2018
- Author(s)
  Huang Li-Yu、Zhao Junjie、Chen Hao、Wan Lixin、Inuzuka Hiroyuki、Guo Jianping、Fu Xuhong、Zhai Yangyang、Lu Zhaoning、Wang Xuefei、Han Ze-Guang、Sun Yihong、Wei Wenyi
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 3569-3569
- DOI
  10.1038/s41467-018-06038-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K19632, KAKENHI-PROJECT-16H05529
[Journal Article] Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors2018
- Author(s)
  Clement Emilie、Inuzuka Hiroyuki、Nihira Naoe T.、Wei Wenyi、Toker Alex
- Journal Title
  
  Science Signaling
  
  Volume: 11 Issue: 521 Pages: 3810-3810
- DOI
  10.1126/scisignal.aao3810
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15811, KAKENHI-PROJECT-18K19632, KAKENHI-PROJECT-16H05529
[Journal Article] The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.2017
- Author(s)
  Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W.
- Journal Title
  
  Sci Signal. doi: 10.1126/scisignal.aah4117.
  
  Volume: 10 Issue: 460 Pages: 1-15
- DOI
  10.1126/scisignal.aah4117
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26253092, KAKENHI-PROJECT-16H05509, KAKENHI-PROJECT-16H05529, KAKENHI-PROJECT-16H05548, KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-16K14664, KAKENHI-PROJECT-15K18365, KAKENHI-PROJECT-15K18977, KAKENHI-PROJECT-15K15689, KAKENHI-PROJECT-17K10432, KAKENHI-PROJECT-26462829
[Journal Article] G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells2017
- Author(s)
  Lijun Liu, Wojciech Michowski, Hiroyuki Inuzuka, Kouhei Shimizu, Naoe Taira Nihira, Joel M. Chick, Na Li, Yan Geng, Alice Y. Meng, Alban Ordureau, Aleksandra Kolodziejczyk, Keith L. Ligon, Roderick T. Bronson, Kornelia Polyak, J. Wade Harper, Steven P. Gygi, Wenyi Wei, Piotr Sicinski
- Journal Title
  
  Nature Cell Biology
  
  Volume: 19 Issue: 3 Pages: 177-188
- DOI
  10.1038/ncb3474
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15811, KAKENHI-PROJECT-16H05529
[Journal Article] Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.2017
- Author(s)
  2.Nihira NT, Ogura K, Shimizu K, North BJ, Zhang J, Gao D, Inuzuka H, Wei W.
- Journal Title
  
  Science Signaling
  
  Volume: 10 Issue: 466
- DOI
  10.1126/scisignal.aai8026
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18977, KAKENHI-PROJECT-16H05529, KAKENHI-PROJECT-16K15811
[Journal Article] NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis.2017
- Author(s)
  Fukushima H, Shimizu K, Watahiki A, Hoshikawa S, Kosho T, Oba D, Sakano S, Arakaki M
- Journal Title
  
  Mol Cell
  
  Volume: Nov 16;68(4) Issue: 4 Pages: 645-658
- DOI
  10.1016/j.molcel.2017.10.018
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17310, KAKENHI-PROJECT-25221303, KAKENHI-PROJECT-17H01606, KAKENHI-PROJECT-16H05529, KAKENHI-PROJECT-16H05548, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-17H04396, KAKENHI-PROJECT-16K15811, KAKENHI-PLANNED-17H06301, KAKENHI-PROJECT-17H06531
[Journal Article] The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function2017
- Author(s)
  Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, Song MS, Xue L, Bronson RT, Kirschner MW, Cui R, Pandolfi PP, Wei W
- Journal Title
  
  Cancer Discovery
  
  Volume: 7 Issue: 4 Pages: 424-441
- DOI
  10.1158/2159-8290.cd-16-0647
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05529, KAKENHI-PROJECT-16K15811
[Journal Article] FBW7 loss promotes chromosomal instability and tumorigenesis via Cyclin E1/CDK2-mediated phosphorylation of CENP-A2017
- Author(s)
  Takada M, Zhang W, Suzuki A, Kuroda T, Yu Z, Inuzuka H, Gao D, Wan L, Zhuang M, Hu L, Zhai B, Fry C, Bloom K, Li G, Karpen G, Wei W, Zhang Q
- Journal Title
  
  Cancer Research
  
  Volume: 77 Issue: 18 Pages: 4881-4893
- DOI
  10.1158/0008-5472.can-17-1240
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15811
[Journal Article] FBW7 loss promotes chromosomal instability and tumorigenesis via Cyclin E1/CDK2-mediated phosphorylation of CENP-A2017
- Author(s)
  Takada M, Zhang W, Suzuki A, Kuroda T, Yu Z, Inuzuka H, Gao D, Wan L, Zhuang M, Hu L, Zhai B, Fry C, Bloom K, Li G, Karpen G, Wei W, Zhang Q
- Journal Title
  
  Cancer Research
  
  Volume: 77 Pages: 4881-4893
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05529
[Journal Article] Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD42017
- Author(s)
  Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, Buckley DL, Qi J, Buser L, Liu P, Inuzuka H, Beck AH, Wang L, Wild PJ, Garraway LA, Rubin MA, Barbieri CE, Wong KK, Muthuswamy SK, Huang J, Chen Y, Bradner JE, Wei W
- Journal Title
  
  Nature Medicine
  
  Volume: 23 Issue: 9 Pages: 1063-1071
- DOI
  10.1038/nm.4378
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05529, KAKENHI-PROJECT-16K15811
[Journal Article] Nutrient-induced FNIP degradation by SCFβ-TRCP regulates FLCN couplex localization and promotes renal cancer progression2016
- Author(s)
  Nagashima, K., Fukushima, H., Shimizu, K., Hidaka, M., Hasumi, H., Ikebe, T., Fukumoto, S., Okabe, K., Inuzuka, H.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 6 Pages: 9947-9960
- DOI
  10.18632/oncotarget.14221
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-26253092, KAKENHI-PROJECT-16H05509, KAKENHI-PROJECT-16H05529, KAKENHI-PROJECT-16H05548, KAKENHI-PROJECT-16K11020, KAKENHI-PROJECT-15K15689, KAKENHI-PROJECT-26462829
[Journal Article] SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination.2014
- Author(s)
  Wu X, Fukushima H, North BJ, Nagaoka Y, Nagashima K, Deng F, Okabe K, Inuzuka H, Wei W.
- Journal Title
  
  Oncotarget
  
  Volume: 5 Pages: 4211-4221
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26462829
[Presentation] Regulation of cell survival through post-translational modifications of MCL-1 in tumorigenesis2019
- Author(s)
  Hiroyuki Inuzuka, Kouhei Shimizu, Mitsuki Chiba, Satoshi Fukumoto, Wenyi Wei
- Organizer
  The Kick-off Symposium of Advanced Graduate Program for Future Medicine and Health Care
- Invited
- Data Source
  KAKENHI-PROJECT-18K19632
[Presentation] Met/Rorl-β-catenin-Bcl-xL axis contributes to the emergence of drug-tolerant cells that evolve into resistant tumors in EGFR-mutant lung cancer.2019
- Author(s)
  Masanori Fujii, Sohei Nakayama, Naoki Akanuma, Gilbert Pan, Ikei S, Kobayashi, Hisashi Takei, Kohei Shimizu, Mariko Ando, Eunyoung Heo, Carol Gergis, Hiroyuki Inuzuka, Wenyi Wei, Daniel B. Costa, Susumu S. KObayashi.
- Organizer
  American Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21746
[Presentation] マクロファージの細菌性炎症応答制御におけるLipin2の役割2019
- Author(s)
  綿引麻美，清水康平，星川聖良，千葉満生，福本敏，江草宏，犬塚博之
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19H03834
[Presentation] Regulation of cell survival through post-translational modifications of MCL-1 in tumorigenesis2019
- Author(s)
  Hiroyuki Inuzuka, Kouhei Shimizu, Mitsuki Chiba, Satoshi Fukumoto, Wenyi Wei
- Organizer
  The Kick-off Symposium of Advanced Graduate Program for Future Medicine and Health Care
- Invited
- Data Source
  KAKENHI-PROJECT-16H05529
[Presentation] Met/Rorl-β-catenin-Bcl-xL axis contributes to the emergence of drug-tolerant cells that evolve into resistant tumors in EGFR-mutant lung cancer2019
- Author(s)
  Masanori Fujii, Sohei Nakayama, Naoki Akanuma, Gilbert Pan, Ikei S. Kobayashi, Hisashi Takei, Kohei Shimizu, Mariko Ando, Eunyoung Heo, Carol Gergis, Hiroyuki Inuzuka, Wenyi Wei, Daniel B. Costa, and Susumu S. Kobayashi
- Organizer
  AACR Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21746
[Presentation] Notch2 変異を介した骨粗鬆症病態の分子機構解明2018
- Author(s)
  犬塚博之
- Organizer
  第41回日本分子生物学会年会ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-16H05529
[Presentation] Lipin2タンパク質分解を介したマクロファージ活性化調節機構の解析2018
- Author(s)
  綿引　麻美、清水　康平、瓜生　英尚、星川　聖良、福本　敏、江草　宏、犬塚　博之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19282
[Presentation] プロテアソーム阻害剤を用いた効率的骨芽細胞分化誘導法の検討2018
- Author(s)
  星川聖良、千葉満生、綿引麻美、清水康平、犬塚博之、福本敏
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-16H05529
[Presentation] プロテアソーム阻害剤を用いた効率的骨芽細胞分化誘導法の検討2018
- Author(s)
  星川　聖良、千葉　満生、綿引　麻美、清水　康平、犬塚　博之、福本　敏
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K19282
[Presentation] プロテアソーム阻害剤を用いた効率的骨芽細胞分化誘導法の検討2018
- Author(s)
  星川聖良、千葉満生、綿引麻美、清水康平、犬塚博之、福本敏
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K19632
[Presentation] アセチル化による抗アポトーシスタンパク質MCL1の安定化機構とその制御方法の検討2018
- Author(s)
  清水　康平、千葉　満生、犬塚　博之、福本　敏
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19282
[Presentation] Lipin 2タンパク質分解を介したマクロファージ活性化調節機構の解析2018
- Author(s)
  綿引麻美、清水康平、瓜生英尚、星川聖良、福本敏、江草宏、犬塚博之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H05529
[Presentation] ユビキチン-プロテアソーム経路の破綻によるMCL1安定化機構とその制御方法の検討2018
- Author(s)
  清水康平、千葉満生、犬塚博之、福本敏
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K19632
[Presentation] ユビキチン-プロテアソーム経路の破綻によるMCL1安定化機構とその制御方法の検討2018
- Author(s)
  清水　康平、千葉　満生、犬塚　博之、福本　敏
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K19282
[Presentation] Lipin 2タンパク質分解を介したマクロファージ活性化調節機構の解析2018
- Author(s)
  綿引麻美、清水康平、瓜生英尚、星川聖良、福本敏、江草宏、犬塚博之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K19632
[Presentation] ユビキチン-プロテアソーム経路の破綻によるMCL1安定化機構とその制御方法の検討2018
- Author(s)
  清水康平、千葉満生、犬塚博之、福本敏
- Organizer
  第60回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-16H05529
[Presentation] Multiple functions of SCF E3 ligase and its implications as a therapeutic target2017
- Author(s)
  犬塚博之
- Organizer
  第１５回松山国際学術シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15811
[Presentation] 抗アポトーシスタンパク質MCL1の安定性制御におけるアセチル化の役割2017
- Author(s)
  清水　康平、犬塚　博之、福島　秀文、福本　敏
- Organizer
  第５９回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-17H04396
[Presentation] タンパク質分解から考える骨及び脂質代謝制御2017
- Author(s)
  犬塚　博之
- Organizer
  第５５回日本小児歯科学会大会（シンポジウム）
- Invited
- Data Source
  KAKENHI-PROJECT-16K15811
[Presentation] 抗アポトーシスタンパク質MCL1の安定性制御におけるアセチル化の役割2017
- Author(s)
  清水　康平、犬塚　博之、福島　秀文、福本　敏
- Organizer
  第５９回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-16H05529
[Presentation] Analysis of proteasome-dependent lipogenic pathway in hepatocytes2017
- Author(s)
  Seira Hoshikawa, Asami Watahiki, Hidefumi Fukushima, Satoshi Fukumoto, Hiroyuki Inuzuka
- Organizer
  Japan-NIH Joint Symposium
- Place of Presentation
  Sendai
- Year and Date
  2017-02-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05529
[Presentation] 抗アポトーシスタンパク質MCL1の安定性制御におけるアセチル化の役割2017
- Author(s)
  清水　康平、犬塚　博之、福島　秀文、福本　敏
- Organizer
  第５９回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-16K15811
[Presentation] Multiple functions of SCF E3 ligase and its implications as a therapeutic target2017
- Author(s)
  犬塚博之
- Organizer
  第１５回松山国際学術シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05529
[Presentation] タンパク質分解から考える骨及び脂質代謝制御2017
- Author(s)
  犬塚　博之
- Organizer
  第５５回日本小児歯科学会大会（シンポジウム）
- Invited
- Data Source
  KAKENHI-PROJECT-16H05529
[Presentation] SCFβ-TRCP依存的なFNIP2タンパク質の量的変化はmTORCシグナル制御とBHD症候群の病態発症に寄与する2016
- Author(s)
  永嶌勝之, 福島秀文, 星川聖良, 綿引麻美, 福本敏, 岡部幸司, 犬塚博之
- Organizer
  第58回歯科基礎医学会学術大会
- Place of Presentation
  札幌コンベンションセンター, 札幌市, 北海道
- Year and Date
  2016-08-24
- Data Source
  KAKENHI-PROJECT-26462829
[Presentation] BHD症候群関連タンパク質FNIP2のプロテアソーム依存的な量的調節機構の解析2016
- Author(s)
  綿引　麻美、星川　聖良、犬塚　博之、江草　宏、福島　秀文
- Organizer
  第39回　日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K15811
[Presentation] 脂質代謝におけるSCF ユビキチンリガーゼの機能と役割2016
- Author(s)
  犬塚　博之
- Organizer
  第70回　東北大学歯学会
- Place of Presentation
  仙台
- Year and Date
  2016-12-02
- Invited
- Data Source
  KAKENHI-PROJECT-16H05529
[Presentation] 脂質代謝における SCF beta-TRCPユビキチンリガーゼ複合体の役割2016
- Author(s)
  犬塚　博之, 福島　秀文, 清水　康平, Wenyi Wei, 福本　敏
- Organizer
  第58回　歯科基礎医学会学術大会
- Place of Presentation
  札幌
- Year and Date
  2016-08-24
- Invited
- Data Source
  KAKENHI-PROJECT-16H05529
[Presentation] ユビキチン－プロテアソーム系を介した肝細胞脂質合成経路の解析2016
- Author(s)
  星川　聖良、綿引　麻美、福島　秀文、福本　敏、犬塚　博之
- Organizer
  第39回　日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H05529
[Presentation] 組織再生に関わる基礎研究基盤の現状脂質代謝におけるSCFβ-TRCPユビキチンリガーゼ複合体の役割2016
- Author(s)
  犬塚博之, 福島秀文, 清水康平, Wei Wenyi, 福本敏
- Organizer
  第58回歯科基礎医学会学術大会
- Place of Presentation
  札幌コンベンションセンター, 札幌市, 北海道
- Year and Date
  2016-08-24
- Data Source
  KAKENHI-PROJECT-26462829

1. Fukumoto Satoshi (30264253)

# of Collaborated Projects: 10 results

# of Collaborated Products: 23 results
2. Hidefumi Fukushima (70412624)

# of Collaborated Projects: 6 results

# of Collaborated Products: 10 results
3. Shimizu Kouhei (70727073)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
4. YAMADA AYA (40295085)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
5. 齋藤正寛 (40215562)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 阪井丘芳 (90379082)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 保住建太郎 (10453804)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 自見英治郎 (40276598)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. Kobayashi Susumu (70792836)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 竹田浩之 (40609393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. 石河真幸 (60432936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 岡本富士雄 (60153938)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 鍛治屋浩 (80177378)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 岡部幸司 (80224046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 江草宏 (30379078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 吉崎恵悟 (10507982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. SAWASAKI Tatsuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Wei Wenyi

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. OGURA Kohei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. ARAKAKI Makiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. 三木義男

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 千葉雄太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 日高真純

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Inuzuka Hiroyuki 犬塚 博之

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歯周組織再生を目指した効率的な抗炎症療法の開発Principal Investigator

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Molecular mechanisms of p75NTR modulation in the regeneration of pulp sensory functionPrincipal Investigator

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Modulation of lipid homeostasis in maintenance and directed differentiation of mesenchymal stem cellsPrincipal Investigator

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Identification of proteolytic signaling pathways regulating reprogramming during iPS cell generationPrincipal Investigator

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[Journal Article] Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages2021

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[Journal Article] Interplay between protein acetylation and ubiquitination controls MCL1 protein stability2021

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[Journal Article] Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy2020

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Inuzuka Hiroyuki 犬塚博之