• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Kanazawa Takeharu  金澤 丈治

ORCIDConnect your ORCID iD *help
… Alternative Names

KANAZAWA Takeharu  金澤 丈治

金澤 丈治  カナザワ タケハル

Less
Researcher Number 20336374
Other IDs
Affiliation (Current) 2025: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2020 – 2023: 自治医科大学, 医学部, 教授
2018 – 2019: 自治医科大学, 医学部, 非常勤講師
2018: 自治医科大学, 医学部, 研究員
2017: 自治医科大学, 医学部, 客員研究員
2010 – 2016: 自治医科大学, 医学部, 准教授 … More
2006 – 2009: 自治医科大学, 医学部, 講師
2003: 琉球大, 医学部附属病院, 講師
2002: 琉球大学, 医学部附属病院, 講師 Less
Review Section/Research Field
Principal Investigator
Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology
Except Principal Investigator
Basic Section 56010:Neurosurgery-related / Otorhinolaryngology / Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology
Keywords
Principal Investigator
頭頸部癌 / 癌抑制遺伝子 / GALR1 / G蛋白共役受容体 / 遺伝子導入 / DNAメチル化 / GPCR / 分子標的治療 / 遺伝子治療 / GALR2 … More / アデノ随伴ウイルスベクター / 個別化治療 / リキッドバイオプシー / HPV関連中咽頭癌 / ソマトスタチン受容体 / メチル化 / エピジェネティックス / 唾液腺導管癌 / Head and Neck Cancer / Tumor Suppressor Gene / 癌抑制遺伝 / 分子標的治療薬 / アポトーシス / 治療 / 頭頚部癌 / G蛋白共役受容体 / AAV / GALR2 / G蛋白共役受容 / G蛋白共役受 / 骨髄細胞 / 二本鎖合成 / 単純ヘルペスチミジンキナーゼ / 放射線治療 … More
Except Principal Investigator
頭頸部癌 / 膠芽腫 / DNAメチル化 / 分子標的治療 / 遺伝子治療 / 癌抑制遺伝子 / G蛋白共役受容体 / 脱メチル化 / TET2遺伝子 / 甲状腺未分化癌 / メチル化 / 遺伝子導入 / 悪性神経膠腫 / 脳腫瘍 / 受容体型チロシンキナーゼ / G蛋白共有受容体 / Combined Therapy / Suicide Gene / Chemotherapy / Head and Neck Cancer / Adeno-associated virus vector / 集学的治療 / 自殺遺伝子 / 抗癌剤 / アデノ随伴ウイルスベクター / GALR1 / AAV Less
  • Research Projects

    (14 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (20 People)
  •  Development of multidrug combination molecular targeted therapeutics based on G protein-coupled receptor interactions in glioblastoma

    • Principal Investigator
      草鹿 元
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Jichi Medical University
  •  Personalized treatment of HPV-associated oropharyngeal cancer by methylation analysis of liquid biopsy samplesPrincipal Investigator

    • Principal Investigator
      金澤 丈治
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Jichi Medical University
  •  甲状腺未分化癌に対する脱メチル化遺伝子治療の基礎研究

    • Principal Investigator
      佐々木 徹
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Jichi Medical University
  •  Multi-targeted demethylation gene therapy for glioblastoma using the TET2 gene.

    • Principal Investigator
      Kusaka Gen
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56010:Neurosurgery-related
    • Research Institution
      Jichi Medical University
  •  頭頸部癌に対するソマトスタチン受容体の遺伝子導入と新規分子標的治療Principal Investigator

    • Principal Investigator
      金澤 丈治
    • Project Period (FY)
      2020 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Jichi Medical University
  •  頭頸部癌でのG蛋白共役受容体のクロストークを利用した分子標的治療薬の開発

    • Principal Investigator
      今吉 正一郎
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Jichi Medical University
  •  Development of novel gene therapy for head and neck cancer applying demethylation mechanismPrincipal Investigator

    • Principal Investigator
      Kanazawa Takeharu
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Jichi Medical University
  •  Molecular Targeted Therapy Utilizing Galanin receptor type 2 signaling for Head and Neck CancerPrincipal Investigator

    • Principal Investigator
      Kanazawa Takeharu
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Jichi Medical University
  •  Preclinical study for Head and Neck Cancer using rAAV-GALR2Principal Investigator

    • Principal Investigator
      KANAZAWA Takeharu
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Jichi Medical University
  •  Gene Therapy for Head and Neck Cancer using Adeno-Associated Virus Vector Harboring Galanin Receptor type1

    • Principal Investigator
      KANAZAWA Hiromi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Jichi Medical University
  •  Galanin Receptor subtypes 2 as therapeutic targets in Head and Neck Squamous cell CarcinomaPrincipal Investigator

    • Principal Investigator
      KANAZAWA Takeharu
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Jichi Medical University
  •  Galanin and galanin receptor type 1 suppress proliferation in squamous carcinoma cells : activation of the extracellular signal regulated kinase pathway and induction of cyclin-dependent kinase inhibitorsPrincipal Investigator

    • Principal Investigator
      KANAZAWA Takeharu
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      Jichi Medical University
  •  アデノ随伴ウイルス(AAV)ベクターを用いた頭頚部癌遺伝子治療と放射線併用Principal Investigator

    • Principal Investigator
      金澤 丈治
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      University of the Ryukyus
  •  TOPOISOMERASE INHIBITORS ENHANCE THE CYTOCIDAL EFFECT OF AAV-HSVTK/GANCICLOVIR ON CANCER CELLS

    • Principal Investigator
      SHINHAMA Akihiko
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Otorhinolaryngology
    • Research Institution
      University of the Ryukyus

All 2023 2022 2019 2018 2017 2015 2014 2012 2011 2010 2009 2008 2007 2006 2004 Other

All Journal Article Presentation

  • [Journal Article] Promoter methylation of galanin receptors as epigenetic biomarkers for head and neck squamous cell carcinomas2019

    • Author(s)
      Kanazawa Takeharu、Misawa Kiyoshi、Shinmura Kazuya、Misawa Yuki、Kusaka Gen、Maruta Mikiko、Sasaki Toru、Watanabe Yusuke、Carey Thomas E.
    • Journal Title

      Expert Review of Molecular Diagnostics

      Volume: 19 Issue: 2 Pages: 137-148

    • DOI

      10.1080/14737159.2019.1567334

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11403
  • [Journal Article] Epigenetic inactivation of galanin receptors in salivary duct carcinoma of the parotid gland: Potential utility as biomarkers for prognosis2018

    • Author(s)
      Kanazawa Takeharu、Misawa Kiyoshi、Fukushima Hirofumi、Misawa Yuki、Sato Yukiko、Maruta Mikiko、Imayoshi Shoichiro、Kusaka Gen、Kawabata Kazuyoshi、Mineta Hiroyuki、Carey Thomas、Nishino Hiroshi
    • Journal Title

      Oncology Letters

      Volume: 15 Pages: 904-9050

    • DOI

      10.3892/ol.2018.8525

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08753, KAKENHI-PROJECT-17K11403
  • [Journal Article] G-Protein-Coupled Receptors: Next Generation Therapeutic Targets in Head and Neck Cancer?2015

    • Author(s)
      Kanazawa T, Misawa K, Misawa Y, Uehara T, Fukushima H, Kusaka G, Maruta M, Carey TE
    • Journal Title

      Toxins

      Volume: 8 Issue: 8 Pages: 2959-2984

    • DOI

      10.3390/toxins7082959

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462599, KAKENHI-PROJECT-26462620
  • [Journal Article] Galanin Receptor 2 Utilizes Distinct Signaling Pathways to Suppress Cell Proliferation and Induce Apoptosis in HNSCC.2014

    • Author(s)
      Kanazawa T, Misawa K, Misawa Y, Maruta M, Uehara T, Kawada K, Nagatomo T, Ichimura K
    • Journal Title

      Molecular Medicine Reports

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592539
  • [Journal Article] Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells2014

    • Author(s)
      Uehara T, Kanazawa T, Mizukami H, Uchibori R, Tsukahara T, Urabe M, Kume A, Misawa K, Carey TE, Suzuki M, Ichimura K, Ozawa K
    • Journal Title

      Cancer Sci

      Volume: 105 Pages: 72-80

    • Data Source
      KAKENHI-PROJECT-23592539
  • [Journal Article] Novel anti-tumor mechanism of galanin receptor type 2 in head and neck squamous cell carcinoma cells.2014

    • Author(s)
      Uehara T, Kanazawa T, Mizukami H, Uchibori R, Tsukahara T, Urabe M, Kume A, Misawa K, Carey TE, Suzuki M, Ichimura K, Ozawa K.
    • Journal Title

      Cancer Sci.

      Volume: 105 Pages: 72-80

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592539
  • [Journal Article] Galanin receptor subtypes 1 and 2 as therapeutic targets in head and neck squamous cell carcinoma2010

    • Author(s)
      Kanazawa T, Misawa K, Carey TE
    • Journal Title

      Expert Opin Ther Targets

      Volume: 14 Pages: 289-302

    • Data Source
      KAKENHI-PROJECT-20592027
  • [Journal Article] Galanin Receptor subtypes 1 and 2 as therapeutic targets in HNSCC2010

    • Author(s)
      Kanazawa, et al
    • Journal Title

      Expert Opinion of Therapeutic Target

      Volume: 14 Pages: 289-302

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592027
  • [Journal Article] Galanin Receptor subtypes 1 and 2 as therapeutic targets in HNSCC2010

    • Author(s)
      Kanazawa, et al
    • Journal Title

      Expert Opinion of Therapeutic Target 14

      Pages: 289-302

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592027
  • [Journal Article] Galanin Receptor subtype 2 suppresses cell proliferation and…2009

    • Author(s)
      Kanazawa, et al
    • Journal Title

      Clinical Cancer Research 15

      Pages: 2222-2230

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20592027
  • [Journal Article] Galanin and galanin receptor type 1 suppress proliferation in squamous carcinoma cells activation of the extracellular sig nal regulated kinase pathway and induction of cyclin-dependent kinase inhibitors2007

    • Author(s)
      Kanazawa T, et. al.
    • Journal Title

      Oncogene 26

      Pages: 5762-5771

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591884
  • [Journal Article] Galanin and galanin receptor type 1 suppress proliferation in squamous carcinoma cells : activation of the extracellular signal regulated kinase pathway and induction of cyclin-dependent kinase inhibitors2007

    • Author(s)
      Kanazawa, T., et. al.
    • Journal Title

      Oncogene 26

      Pages: 5762-5771

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591884
  • [Journal Article] Galanin and galanin receptor type 1 suppress proliferation in squamous carcinoma cells:activation of the extracellular signal regulated kinase pathway and induction of cyclin-dependent kinase inhibitors2007

    • Author(s)
      Kanazawa T, et. al.
    • Journal Title

      Oncogene 26

      Pages: 5762-5771

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18591884
  • [Journal Article] Topoisomerase inhibitors enhance the cytocidal effect of AAV-HSVth/ganciclovir on head and neck cancer cells.2004

    • Author(s)
      Takeharu Kanazawa, Hiroaki Mizukami, Hiroshi Nishino, Takashi Okada, Yutaka Hanazono, Akihiro Kume, Ken Kitamura, Keiichi Ichimura, Keiya Oazawa
    • Journal Title

      International Journal of Oncology 25

      Pages: 729-735

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14571627
  • [Journal Article] Galanin Receptor 2 Utilizes Distinct Signaling Pathways to Suppress Cell Proliferation and Induce Apoptosis in HNSCC

    • Author(s)
      Kanazawa T, Misawa K, Misawa Y, Maruta M, Uehara T, Kawada K, Nagatomo T, Ichimura K
    • Journal Title

      Mol Med Rep

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-23592539
  • [Presentation] Surgical outcomes for primary hyperparathyroidism at Jichi Medical University2023

    • Author(s)
      Takeharu Kanazawa, Toru Sasaki, Takeshi Igarashi
    • Organizer
      The 16th Taiwan-Japan conference on otolaryngology-head and neck surgery
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K09672
  • [Presentation] ソマトスタチン受容体 2型が頭頸部癌に与える影響2022

    • Author(s)
      金澤 丈治,五十嵐丈之,松山浩太,野澤美樹,翁長龍太郎,伊藤 真人 ,三澤  清
    • Organizer
      第123回日本耳鼻咽喉科頭頸部外科学会 総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-20K09697
  • [Presentation] 頭頸部癌における ソマトスタチン受容体の役割2022

    • Author(s)
      金澤丈治
    • Organizer
      第2回日本耳鼻咽喉科免疫アレルギー感染症学会 総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-20K09697
  • [Presentation] 頭頸部癌細胞でのソマトスタチン受容体2型の機能解析2022

    • Author(s)
      金澤 丈治,三澤  清,長友孝文,翁長龍太郎
    • Organizer
      第46回日本頭頸部癌学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-20K09697
  • [Presentation] 頭頸部癌におけるソマトスタチン受容体の役割2022

    • Author(s)
      金澤 丈治,三澤 清,甲州 亮太,伊藤 真人
    • Organizer
      第2回 日本耳鼻咽喉科免疫アレルギー感染症学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-20K09697
  • [Presentation] Galanin Receptor 2 Utilizes Distinct Signaling Pathways to Suppress Cell Proliferation and Induce Apoptosis in HNSCC.2017

    • Author(s)
      Kanazawa T, Misawa K
    • Organizer
      9th Intrernational Conference on Head and Neck Cancer.
    • Place of Presentation
      Seattle
    • Year and Date
      2017-07-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462620
  • [Presentation] DNA methylation in Thyroid Cancer2017

    • Author(s)
      Kanazawa T, Kisawa K.
    • Organizer
      2nd Congress of Asia-Pacific Society of Thyroid Surgery.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11403
  • [Presentation] アデノ随伴ウイルスベクターを用いたガラニン受容体2型遺伝子導入による抗腫瘍効果の検討2012

    • Author(s)
      上原貴行,金澤丈治,市村恵一,鈴木幹男
    • Organizer
      第113回日本耳鼻咽喉科学会総会・学術講演会
    • Place of Presentation
      新潟
    • Data Source
      KAKENHI-PROJECT-23592539
  • [Presentation] Galanin受容体2型導入による頭頸部癌遺伝子治療研究2012

    • Author(s)
      金澤丈治,上原貴行,三澤清,鈴木幹男,市村恵一
    • Organizer
      第36回日本頭頸部癌学会総会・学術講演会
    • Place of Presentation
      松江
    • Data Source
      KAKENHI-PROJECT-23592539
  • [Presentation] 頭頸部扁平上皮癌におけるガラニン受容体2型を介する新たな抗腫瘍機構の解明2012

    • Author(s)
      上原貴行,金澤丈治,水上浩明,内堀亮介,塚原智典,卜部匡司,久米晃啓,三澤清,小澤敬也
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23592539
  • [Presentation] GALR2 has the Different Signaling Pathway to Suppress Cell Proliferation and Induce Apoptosis in p53 Mutant Head and Neck Cancer Cells2011

    • Author(s)
      Kanazawa T, Carey TE
    • Organizer
      102^<th> Annual Meeting American Association for Cancer Research
    • Place of Presentation
      Orlando
    • Data Source
      KAKENHI-PROJECT-20592027
  • [Presentation] Galanin Receptor subtype 2 Suppresses Cell Proliferation and Induces Apoptosis in p53 Mutant Head and Neck Cancer Cells.2008

    • Author(s)
      Kanazawa T
    • Organizer
      7^<th> Internatinal Conference on Head and Neck Cancer
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-07-19
    • Data Source
      KAKENHI-PROJECT-20592027
  • [Presentation] Galanin Receptor Type 1 inhibits cell proliferation in Squamous Carcinoma Cells via Activation of the Extracellular Signal Regulated Kinase Pathway2006

    • Author(s)
      Kanazawa, T., et. al.
    • Organizer
      AHNS 2006 Annual Meeting & Research Workshop on the Biology, Prevention and Treatment of Head & Neck Cancer
    • Place of Presentation
      Chicago,USA
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18591884
  • [Presentation] Galanin Receptor Type 1 inhibits cell proliferation in Squamous Carcinoma Cells via Activation of the Extracellular Signal Regulated Kinase Pathway

    • Author(s)
      Kanazawa, T., et. al.
    • Organizer
      AHNS 2006 Annual Meeting & ResearchWorkshop on Biology
    • Place of Presentation
      Prevention and Treatment of Head & Neck Cancer
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591884
  • 1.  MIZUKAMI Hiroaki (20311938)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 3 results
  • 2.  ICHIMURA Keiichi (00010471)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 6 results
  • 3.  Kusaka Gen (00265258)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 4.  佐々木 徹 (50332614)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 5.  NISHINO Hiroshi (50245057)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  三澤 清 (90334979)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 7.  今吉 正一郎 (00570186)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  伊藤 真人 (50283106)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 9.  KANAZAWA Hiromi (40570643)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  UEHARA Takayuki (00644402)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 11.  SHINHAMA Akihiko (60284973)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  KOUCHI Ayako (30264500)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  GANAHA Akira (00347155)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  玉城 三七夫 (80325844)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  大輪 達仁 (60284981)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  長谷川 昌宏 (10347156)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  福嶋 敬宜 (40384937)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  内山 拓 (80790724)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  内田 晶子 (70866889)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  佐藤 由紀子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi