Yamanaka Hiroki 山中博樹

… Alternative Names

YAMANAKA Hiroki 山中博樹

中山博樹ナカヤマヒロキ

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Researcher Number	20340995
Other IDs
Affiliation (Current)	2025: 兵庫医科大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 兵庫医科大学, 薬学部, 准教授 2022: 兵庫医科大学, 医学部, 講師 2011 – 2019: 兵庫医科大学, 医学部, 講師 2008 – 2009: Hyogo College of Medicine, 医学部, 講師 2007: Hyogo College of Medicine, Faculty of Medicine, Instructor 2003 – 2006: 兵庫医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Pain science / General anatomy (including Histology/Embryology) / Basic Section 59010:Rehabilitation science-related / Nerve anatomy/Neuropathology / Nerve anatomy/Neuropathology Except Principal Investigator Biological Sciences / Basic Section 59010:Rehabilitation science-related / Pain science / Nerve anatomy/Neuropathology / Surgical dentistry / Nerve anatomy/Neuropathology / Pain science
Keywords	Principal Investigator シナプス可塑性 / 脊髄後角 / L1-CAM / 細胞間接着因子 / シナプス / 可塑性 / 神経傷害性疼痛 / 後根神経節 / 神経因性疼痛 / 形態変化 … More / 細胞間接着 / proteolysis / neuropathic pain / 再生関連因子 / リン酸化 / JNK / GAP-43 / 細胞外プロテアーゼ / ニューロン / タンパク分解 / 細胞外基質蛋白 / ネットワーク / 疼痛伝達 / 細胞外環境修飾 / 後角サーキット / 後角ニューロン / 痒み / 末梢神経損傷 / 痛み / ニューロトリプシン / 細胞外環境改変 / セリンプロテアーゼ / post transcriptional regulation / plasticuty / synapse / dorsal horn / dorsal root gangliae / cell adhesion molecules / neurpnathic pain / p38 MAPK / synaptic reorganization / dorsal horn synapse / Dorsal root gamglia / cell adhesion / 翻訳後修飾 / MAP kinase / 翻訳後調節 / 神経可塑性 / カルシウムチャネル / 接着因子 / casein kinase 2 / 神経障害性疼痛 / Casein kinase 2 / CHL1 / proteolisis / Dorsal root ganglia / plasticity / Dorsal horn / dorsal root ganglion / plasminogen activator … More Except Principal Investigator 脊髄後角 / 神経障害性疼痛 / 疼痛 / マイクログリア / プロテアーゼ / グリア / L1-CAM / 可塑性 / 後根神経節 / 脊髄 / 接着因子 / 痛み / ダイノルフィン / サブスタンスP / 神経活性ペプチド / 神経活性物質 / 上行性経路 / 脚傍核 / 細胞間接着 / シナプス可塑性 / p38 / ROCK / Rho / 合成酵素 / プロスタグランジン / ニューロン / 脂質メディエーター / nociception / nerve in jury / neuritis / pain / trigeminal nerve / 三叉神経 / 末梢神経障害 / 神経炎 / 歯学 / p38 MAPK / P2Y受容体 / ADP / 形態変化 / Rho kinase / MAP kinase / ATP受容体 / 疼痛行動 / ニューロパチックペイン / 後根 / アストロサイト / tPA / 神経傷害 Less

JNK活性による損傷c-fiber終末の形態的可塑性と疼痛への関与Principal Investigator
- Principal Investigator
  
  山中博樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Hyogo Medical University
運動器疼痛による情動系脳内ネットワーク変調のゲートキーパー、腕傍核の調節機構
- Principal Investigator
  
  野口光一
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  Hyogo Medical University
Expression of neurotrypsin in dorsal root ganglia and dorsal horn following peripheral nerve injuryPrincipal Investigator
- Principal Investigator
  
  Hiroki Yamanaka
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pain science
- Research Institution
  Hyogo Medical University
Aberrant axo-axonic synaptic reorganization in the calcium channel subunit alpha2 delta-1/L1-CAM-containing central terminals of injured c-fibers in the spinal cord of a neuropathic pain model
- Principal Investigator
  
  Noguchi Koichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pain science
- Research Institution
  Hyogo Medical University
Alpha2 delta-1 mediated synaptic plasticity in the dorsal horn of peripheral nerve injury model ratsPrincipal Investigator
- Principal Investigator
  
  Yamanaka Hiroki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pain science
- Research Institution
  Hyogo Medical University
Molecular basis of spinal glia/endothelium/neurons interaction as the mechanisms of development and maintenance of chronic pain
- Principal Investigator
  
  Noguchi Koichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Hyogo Medical University
RhoA/ROCK pathway mediates morphological changes downstream of P2Y12/13 receptors in spinal microglia following peripheral nerve injury
- Principal Investigator
  
  KOBAYASHI Kimiko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Hyogo Medical University
Involvement of phosphorylated L1-CAM in the plastic changes of nociecptive circuit following peripheral nerve injuryPrincipal Investigator
- Principal Investigator
  
  YAMANAKA Hiroki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Hyogo Medical University
A cell adhesion molecule close homologue of L1 increased in primary afferent terminal contributes to the development and maintenance of neuropathic painPrincipal Investigator
- Principal Investigator
  
  YAMANAKA Hiroki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Hyogo College of Medicine
脊髄根損傷モデルラットの脊髄における細胞外プロテアーゼtPAの役割
- Principal Investigator
  
  清野大輔
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pain science
- Research Institution
  Hyogo Medical University
神経因性疼痛における細胞間接着因子L1-CAMの役割
- Principal Investigator
  
  野口光一
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hyogo College of Medicine
Alteration of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic painPrincipal Investigator
- Principal Investigator
  
  YAMANAKA Hiroki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Hyogo College of Medicine
侵害受容神経回路網における細胞間接着因子の役割
- Principal Investigator
  
  NOGUCHI Koichi
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hyogo Medical University
Role of inflammation on neuropathic pain in trigeminal nerve
- Principal Investigator
  
  TOKUNAGA Atsushi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Hyogo College of Medicine
末梢神経損傷によるtPA発現と細胞外基質蛋白の改変及び疼痛発生への影響Principal Investigator
- Principal Investigator
  
  山中博樹
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Hyogo Medical University

[Journal Article] COX2 expression plays a role in spinal cord injury-induced neuropathic pain2024
- Author(s)
  Toi Masakazu、Tachibana Toshiya、Noguchi Koichi、Yamanaka Hiroki、Kobayashi Kimiko、Okubo Masamichi、Kishima Kazuya、Dai Yi
- Journal Title
  
  Neuroscience Letters
  
  Volume: 823 Pages: 137663-137663
- DOI
  10.1016/j.neulet.2024.137663
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24704
[Journal Article] Hippocalcin-like 4, a neural calcium sensor, has a limited contribution to pain and itch processing2020
- Author(s)
  Christopher G. Alvaro, Joao M. Braz, Mollie Bernstein, Katherine A. Hamel,Veronica Craik, Hiroki Yamanaka, Allan I. Basbaum.
- Journal Title
  
  PLoS One
  
  Volume: 15 Issue: 2 Pages: e0226289-e0226289
- DOI
  10.1371/journal.pone.0226289
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09047
[Journal Article] TRPA1-expressing lamina propria mesenchymal cells regulate colonic motility2019
- Author(s)
  Yang Yanjing、Wang Shenglan、Kobayashi Kimiko、Hao Yongbiao、Kanda Hirosato、Kondo Takashi、Kogure Yoko、Yamanaka Hiroki、Yamamoto Satoshi、Li Junxiang、Miwa Hiroto、Noguchi Koichi、Dai Yi
- Journal Title
  
  JCI Insight
  
  Volume: 4 Issue: 9 Pages: 122402-122402
- DOI
  10.1172/jci.insight.122402
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04113, KAKENHI-PROJECT-17K19736
[Journal Article] Differential expression of mGluRs in rat spinal dorsal horns and their modulatory effects on nocifensive behaviors2019
- Author(s)
  Okubo Masamichi、Yamanaka Hiroki、Kobayashi Kimiko、Noguchi Koichi
- Journal Title
  
  Molecular Pain
  
  Volume: 15 Pages: 1-13
- DOI
  10.1177/1744806919875026
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04113, KAKENHI-PROJECT-17K09047, KAKENHI-PROJECT-17K19736
[Journal Article] Negative Regulation of TRPA1 by AMPK in Primary Sensory Neurons as a Potential Mechanism of Painful Diabetic Neuropathy.2018
- Author(s)
  Wang S, Kobayashi K, Kogure Y, Yamanaka H, Yamamoto S, Yagi H, Noguchi K, Dai Y
- Journal Title
  
  Diabetes
  
  Volume: 67(1) Issue: 1 Pages: 98-109
- DOI
  10.2337/db17-0503
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09004, KAKENHI-PROJECT-17K09048, KAKENHI-PROJECT-17K19736, KAKENHI-PROJECT-17H04113
[Journal Article] Upregulation of calcium channel alpha-2-delta-1 subunit in dorsal horn contributes to spinal cord injury-induced tactile allodynia2018
- Author(s)
  Kusuyama K, Tachibana T, Yamanaka H, Okubo M, Yoshiya S, Noguchi K.
- Journal Title
  
  Spine J
  
  Volume: 18 Issue: 6 Pages: 1062-1069
- DOI
  10.1016/j.spinee.2018.01.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19736, KAKENHI-PROJECT-17H04113
[Journal Article] Recombinant interleukin-4 alleviates mechanical allodynia via injury-induced interleukin-4 receptor alpha in spinal microglia in a rat model of neuropathic pain.2018
- Author(s)
  Okutani Hiroai, Yamanaka Hiroki, Kobayahi Kimiko, Okubo Masamichi, Noguchi Koichi.
- Journal Title
  
  Glia
  
  Volume: 66 Issue: 8 Pages: 1775-1787
- DOI
  10.1002/glia.23340
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19736, KAKENHI-PROJECT-17H04113
[Journal Article] Macrophage-Colony Stimulating Factor Derived from Injured Primary Afferent Induces Proliferation of Spinal Microglia and Neuropathic Pain in Rats2016
- Author(s)
  Masamichi Okubo, Hiroki Yamanaka, Kimiko Kobayashi, Yi Dai, Hirosato Kanda, Hideshi Yagi and Koichi Noguchi
- Journal Title
  
  Plos ONE
  
  Volume: 11 Issue: 4 Pages: e0153375-e0153375
- DOI
  10.1371/journal.pone.0153375
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15205, KAKENHI-PROJECT-15K15557, KAKENHI-PROJECT-25290016, KAKENHI-PROJECT-16K19220
[Journal Article] Annexin A2 in primary afferents contributes to neuropathic pain associated with tissue type plasminogen activator.2016
- Author(s)
  Yamanaka H, Kobayashi K, Okubo M, Noguchi K.
- Journal Title
  
  Neuroscience
  
  Volume: 314 Pages: 189-199
- DOI
  10.1016/j.neuroscience.2015.11.058
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15557, KAKENHI-PROJECT-25290016
[Journal Article] Peripherally increased artemin is a key regulator of TRPA1/V1 expression in primary afferent neurons.2015
- Author(s)
  Yasuko Ikeda-Miyagawa, Kimiko Kobayashi, Hiroki Yamanaka, Masamichi Okubo, Shenglan Wang, Yi Dai, Hideshi Yagi, Munetaka Hirose, Koichi Noguchi
- Journal Title
  
  Mol Pain
  
  Volume: 11 Pages: 8-8
- DOI
  10.1186/s12990-015-0004-7
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25290016
[Journal Article] Leukotriene enhances NMDA-induced inward currents in dorsal horn neurons of the rat spinal cord after peripheral nerve injury2015
- Author(s)
  Kiyoyuki Y, Taniguchi W, Okubo M, Yamanaka H, Kobayashi K, Nishio N, Nakatsuka T, Noguchi K
- Journal Title
  
  Mol. Pain
  
  Volume: 11 Pages: 53-53
- DOI
  10.1186/s12990-015-0059-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15205, KAKENHI-PROJECT-15K15557, KAKENHI-PROJECT-25290016
[Journal Article] RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain.2015
- Author(s)
  Tatsumi E1, Yamanaka H, Kobayashi K, Yagi H, Sakagami M, Noguchi K.
- Journal Title
  
  Glia
  
  Volume: 63 Issue: 2 Pages: 216-228
- DOI
  10.1002/glia.22745
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24500416, KAKENHI-PROJECT-25290016
[Journal Article] Upregulated glial cell line-derived neurotrophic factor through cyclooxygenase-2 activation in the muscle is required for mechanical hyperalgesia after exercise in rats.2013
- Author(s)
  S. Murase, E. Terazawa, K. Hirate, H. Yamanaka, H. Kanda, K. Noguchi, H. Ota, F. Queme, T. Taguchi, and K. Mizumura.
- Journal Title
  
  Journal of Physiology
  
  Volume: 591 Issue: 12 Pages: 3035-3048
- DOI
  10.1113/jphysiol.2012.249235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390154, KAKENHI-PROJECT-24659106, KAKENHI-PROJECT-24659688, KAKENHI-PROJECT-25282160, KAKENHI-PROJECT-25290016
[Journal Article] COX-1-dependent prostaglandin D2 in microglia contributes to neuropathic pain via DP2 receptor in spinal neurons.2013
- Author(s)
  Kanda H, Kobayashi K, Yamanaka H, Noguchi K.
- Journal Title
  
  Glia
  
  Volume: 61 Issue: 6 Pages: 943-956
- DOI
  10.1002/glia.22487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659688, KAKENHI-PROJECT-25290016
[Journal Article] Phosphorylation of Ezrin/Radixin/Moesin(ERM) protein in spinal microglia following peripheral nerve injury and lysophosphatidic acid administration.2012
- Author(s)
  Kashimoto R, Yamanaka H, Kobayashi K, Okubo M, Yagi H, Mimura O, Noguchi K.
- Journal Title
  
  Glia
  
  Volume: 61 Issue: 3 Pages: 338-48
- DOI
  10.1002/glia.22436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300115, KAKENHI-PROJECT-23500386, KAKENHI-PROJECT-23500418, KAKENHI-PROJECT-24659688, KAKENHI-PUBLICLY-23116517
[Journal Article] Noguchi K. Multiple P2Y subtypes in spinal microglia are involved in neuropathic pain after peripheral nerve injury.2012
- Author(s)
  Kobayashi K, Yamanaka H, Yanamoto F, Okubo M
- Journal Title
  
  Glia
  
  Volume: 60 Issue: 10 Pages: 1529-39
- DOI
  10.1002/glia.22373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300115, KAKENHI-PROJECT-22600012, KAKENHI-PROJECT-23500418, KAKENHI-PROJECT-24659688, KAKENHI-PUBLICLY-23116517
[Journal Article] Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury.2012
- Author(s)
  Okubo M, Yamanaka H, Kobayashi K, Kanda H, Dai Y, Noguchi K.
- Journal Title
  
  Mol Pain
  
  Volume: 8 Pages: 8-8
- DOI
  10.1186/1744-8069-8-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300115, KAKENHI-PROJECT-22700371, KAKENHI-PROJECT-23500418, KAKENHI-PROJECT-23590730, KAKENHI-PROJECT-24659688, KAKENHI-PUBLICLY-23116517
[Journal Article] Increase of close homolog of cell adhesion molecule L1 in primary afferent by nerve injury and the contribution to neuropathic pain2011
- Author(s)
  Yamanaka H, Kobayashi K, Okubo M, Fukuoka T, Noguchi K.
- Journal Title
  
  Journal of Comparative Neurology
  
  Volume: 519 Issue: 8 Pages: 1597-615
- DOI
  10.1002/cne.22588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21600016, KAKENHI-PROJECT-22300115, KAKENHI-PUBLICLY-23116517, KAKENHI-PROJECT-23500418
[Journal Article] Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain.2008
- Author(s)
  Wang, S., Dai, Y., Fukuoka, T., Yamanaka, H., Kobayashi, K., Obata, K., Cui, X., Tominaga, M., Noguchi, K.
- Journal Title
  
  Brain 131
  
  Pages: 1241-1251
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790170
[Journal Article] Activation of extracellular signal-regulated protein kinase in sensory neurons after noxious gastric distention and its involvement in acute visceral pain in rats.2008
- Author(s)
  Sakurai, J., Obata, K., Ozaki, N., Tokunaga, A., Kobayashi, K., Yamanaka, H., Dai, Y., Kondo, T., Miyoshi, K., Sugiura, Y., Matsumoto, T., Miwa, H., Noguchi, K.
- Journal Title
  
  Gastroenterology 134
  
  Pages: 1094-1103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790170
[Journal Article] Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury.2008
- Author(s)
  Katsura, H., Obata, K., Miyoshi, K., Kondo, T., Yamanaka, H., Kobayashi, K., Dai, Y., Fukuoka, T., Sakagami, M., Noguchi, K.
- Journal Title
  
  Glia 56
  
  Pages: 723-733
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790170
[Journal Article] P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain.2008
- Author(s)
  Kobayashi, K., Yamanaka, H., Fukuoka, T., Dai, Y., Obata, K., Noguchi, K.
- Journal Title
  
  J. Neurosci. 28
  
  Pages: 2892-2902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790170
[Journal Article] Differential activation of p38 and extracellular signal-regulated kinase in spinal cord in a model of bee venom-induced inflammation and hyperalgesia.2008
- Author(s)
  Cui, X.Y., Dai, Y., Wang, S.L., Yamanaka, H., Kobayashi, K., Obata, K., Chen, J., Noguchi, K.
- Journal Title
  
  Mol. Pain 4
  
  Pages: 17-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790170
[Journal Article] Comparative study of the distribution of the alpha-subunits of voltage-gated sodium channels in normal and axotomized rat dorsal root ganglion neurons.2008
- Author(s)
  Fukuoka, T., Kobayashi, K., Yamanaka, H., Obata, K., Dai, Y., Noguchi, K.
- Journal Title
  
  J. Comp. Neurol. 510
  
  Pages: 188-206
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790170
[Journal Article] Activation of fibroblast growth factor receptor by axotomy, throughdownstream p38 in dorsal root ganglion, contributes to neuropathic pain2007
- Author(s)
  Yamanaka, H., et. al.
- Journal Title
  
  Neuroscience 150
  
  Pages: 202-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18021037
[Journal Article] Alternation of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain2007
- Author(s)
  Yamanaka, H., et. al.
- Journal Title
  
  Eur.J.Neurosci. 25
  
  Pages: 1097-1111
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500269
[Journal Article] Activation of fibroblast growth factor receptor by axotomy,through downstream p38 in dorsal root ganglion,contributes to neuropathic pain2007
- Author(s)
  Yamanaka, H., et. al.
- Journal Title
  
  Neuroscience 150
  
  Pages: 202-211
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19603020
[Journal Article] Activation of fibroblast growth factor receptor by axotomy,through downstream p38 in dorsal root ganglion,contributes to neuropathic pain2007
- Author(s)
  Yamanaka, H., et. al.
- Journal Title
  
  Neuroscience 150
  
  Pages: 202-211
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18500269
[Journal Article] Induction of plasminogen activator inhibitor-1 and -2 in dorsal root ganglion neurons after peripheral nerve injury2005
- Author(s)
  Yamanaka, H. et al.
- Journal Title
  
  Neuroscience 132・1
  
  Pages: 183-191
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17592121
[Journal Article] Induction of plasminogen activator inhibitor-1 and -2 in dorsal root ganglion neurons after peripheral nerve injury2005
- Author(s)
  Yamanaka, H. et al.
- Journal Title
  
  Neuroscience 132・1
  
  Pages: 183-191
- Data Source
  KAKENHI-PROJECT-17023043
[Journal Article] Induction of plasminogen activator inhibitor-1 and-2 in dorsal root ganglion neurons after peripheral nerve injury2005
- Author(s)
  Yamanaka, H. et al.
- Journal Title
  
  Neuroscience 132-1
  
  Pages: 183-191
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17592121
[Journal Article] Tissue plasminogen activator in primary afferents induces dorsal horn excitability and pain response after peripheral nerve injury2004
- Author(s)
  Yamanaka, H.et al.
- Journal Title
  
  Eur.J.Neurosci. 19
  
  Pages: 93-102
- Data Source
  KAKENHI-PROJECT-15790111
[Journal Article] Alternation of the cell adhesion molecule Li expression in a specific subset of primary afferent neurons contributes to neuropathic pain
- Author(s)
  Yamanaka, H. et. al
- Journal Title
  
  Eur. J. Neurosci 25
  
  Pages: 1097-1111
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500269
[Journal Article] Activation of fibroblast growth factor receptor by axotomy, through downstream p38 in dorsal root ganglion, contributes to the neuropathic pain
- Author(s)
  Yamanaka, H., et. al.
- Journal Title
  
  Neuroscience 150
  
  Pages: 202-211
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500269
[Presentation] Role of JNK in the morphological changes of injured C-fiber terminal via the phosphorylation of GAP43 in the dorsal horn of a rat neuropathic pain model2023
- Author(s)
  山中博樹,　小林希実子,　神田浩里,　野口光一
- Organizer
  Neuroscience 2023: Society for Neurocience, Annual Meeting.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K10574
[Presentation] 脊髄後角神経回路におけるmGluRの発現解析と炎症性疼痛との関係2019
- Author(s)
  大久保正道, 山中博樹, 小林希実子,野口光一
- Organizer
  第１２４回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-17K09047
[Presentation] 末梢神経損傷後の脊髄後角neuronで増加するBDNF2019
- Author(s)
  小林希実子, 山中博樹, 大久保正道, 野口光一
- Organizer
  第１２４回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-17K09047
[Presentation] TRPA1-expressing lamina propria mesenchymal cells regulate colonic motility through prostaglandin release2019
- Author(s)
  Yang Yanjing, Wang Shenglan, Kobayashi Kimiko, Kanda Hirosato, Kogure Yoko, Yamamoto Satoshi, Yamanaka Hiroki, Noguchi Koichi, Dai Yi .
- Organizer
  The 49th Annual Meeting of the Society for Neuroscience
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09047
[Presentation] Cellullar distribution of brain derived neurotrophic factor in spinal dorsal horn of neuropathic pain model rats2018
- Author(s)
  Kobayashi K, Yamanaka H, Okubo M, Noguchi K.
- Organizer
  17th IASP World Congerss on Pain
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04113
[Presentation] Cellullar distribution of brain derived neurotrophic factor in spinal dorsal horn of neuropathic pain model rats2018
- Author(s)
  Kobayashi K, Yamanaka H, Okubo M, Noguchi K.
- Organizer
  17th IASP World Congress on Pain
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04113
[Presentation] Effect of peripheral nerve injury on the Axo-axonic contacts between injured C-fiber and spinal neuron.2018
- Author(s)
  Yamanaka H, Kobayashi K, Okubo M, Noguchi K.
- Organizer
  17th IASP World Congerss on Pain
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04113
[Presentation] Effect of peripheral nerve injury on the Axo-axonic contacts between injured C-fiber and spinal neuron.2018
- Author(s)
  Yamanaka H, Kobayashi K, Okubo M, Noguchi K.
- Organizer
  17th IASP World Congress on Pain
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04113
[Presentation] 末梢神経損傷後の脊髄におけるPGE2合成酵素とEP受容体の発現変化2015
- Author(s)
  神田浩里, 小林希実子, 山中博樹, 大久保正道, 野口光一
- Organizer
  第37回日本疼痛学会
- Place of Presentation
  市民会館崇城大学ホール（熊本県熊本市）
- Year and Date
  2015-07-04
- Data Source
  KAKENHI-PROJECT-25290016
[Presentation] Glial TNF alpha induces COX-2 expression and PGI2 synthesis in the spinal endothelial cells in neuropathic pain2014
- Author(s)
  K.Kanda, Kobayashi K, Yamanaka H, Noguchi K.
- Organizer
  15th World Congress on Pain
- Place of Presentation
  Buenos Aires, Argentine
- Year and Date
  2014-10-09
- Data Source
  KAKENHI-PROJECT-25290016
[Presentation] 脊髄損傷モデルにおけるカルシウムチャネルα2δ－1サブユニットの発現2014
- Author(s)
  楠山一樹,　橘　俊哉,　山中博樹,　吉矢晋一,　野口光一.
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  横浜
- Year and Date
  2014-09-11
- Data Source
  KAKENHI-PROJECT-25290016
[Presentation] 脊髄microgliaに対するRhoキナーゼ阻害剤の影響と神経傷害性疼痛への関与2014
- Author(s)
  山中博樹, 巽恵美子, 小林希実子, 阪上雅史, 野口光一.
- Organizer
  第119回日本解剖学会総会・全国学術集会
- Place of Presentation
  栃木
- Data Source
  KAKENHI-PROJECT-23500418
[Presentation] 脊髄microgliaに対するRhoキナーゼ阻害剤の影響と神経障害性疼痛への関与2014
- Author(s)
  山中博樹, 巽恵美子, 小林希実子, 阪上雅史, 野口光一
- Organizer
  第119回日本解剖学会総会全国学術集会
- Place of Presentation
  自治医科大学
- Data Source
  KAKENHI-PROJECT-24500416
[Presentation] 末梢神経損傷により誘導される脊髄Cox2/PGIS発言へのTNF alpha の関与2014
- Author(s)
  小林希実子,　神田浩里,　山中博樹,　野口光一.
- Organizer
  第36回日本疼痛学会
- Place of Presentation
  大阪
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-25290016
[Presentation] Leukotriene enhances NMDA induced inward currents in dorsal horn neurons of rat spinal cord after peripheral nerve injury.2013
- Author(s)
  Kiyoyuki Y, Yamanaka H, Kobayashi K, Okubo M, Noguchi K, Taniguchi W, Nishio N, Nakatsuka T.
- Organizer
  The 43nd Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego, U.S.A
- Data Source
  KAKENHI-PROJECT-25290016
[Presentation] 末梢神経損傷モデルラット後根神経節における Annexin A2 の発現誘導と仏痛への関与2013
- Author(s)
  山中博樹, 小林希実子, 神田浩里, 野口光一.
- Organizer
  第35回日本疼痛学会
- Place of Presentation
  さいたま
- Data Source
  KAKENHI-PROJECT-23500418
[Presentation] 脊髄microgliaに対するRhoキナーゼ阻害剤の影響と神経障害性疼痛への関与2013
- Author(s)
  巽恵美子, 山中博樹, 小林希実子, 阪上雅史, 野口光一
- Organizer
  第35回日本疼痛学会
- Place of Presentation
  さいたま市大宮ソニックシティ
- Data Source
  KAKENHI-PROJECT-24500416
[Presentation] Expression of colony-stimulateing factors and their receptors in dorsal root ganglion and spinal cord after peripheral nerve injury.2013
- Author(s)
  Okubo M, Yamanaka H, Kobayashi K, Kanda H, Dai Y, Noguchi K.
- Organizer
  The 43nd Annual Meeting of the Society for Neuroscience
- Place of Presentation
  San Diego, U.S.A
- Data Source
  KAKENHI-PROJECT-25290016
[Presentation] Changes in the expression pattern of P2X receptors in the rat DRG following peripheral nerve injury.2012
- Author(s)
  Kobayashi K, Yamanaka H, Noguchi K.
- Organizer
  The 42nd Annual Meeting of the Society for Neuroscience (Neuroscience 2012)
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-24500416
[Presentation] Phosphorylation of L1-CAM is differentially regulated in somata and central terminal of DRG neuron after nerve injury.2012
- Author(s)
  Yamanaka H, Kobayashi K, Noguchi K.
- Organizer
  The 42nd Annual Meeting of the Society for Neuroscience
- Place of Presentation
  New Orleans, USA
- Data Source
  KAKENHI-PROJECT-23500418
[Presentation] Phosphorylation of L1-CAM is differentially regulated in somata and central terminal of DRG neuron after nerve injury2012
- Author(s)
  Yamanaka H, Kobayashi K, Noguchi K
- Organizer
  The 42nd Annual Meeting of the Society for Neuroscience (Neuroscience 2012)
- Place of Presentation
  New Orleans
- Year and Date
  2012-10-13
- Data Source
  KAKENHI-PROJECT-23500418
[Presentation] Expression of leukotriene receptors in the rat dorsal root ganglion and the effect on pain behaviors.2011
- Author(s)
  Okubo M, Yamanaka H, Kobayashi K, Fukuoka T, Dai Y Noguchi K
- Organizer
  The 41th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-23500418
[Presentation] Expression of PGD2 and TXA2 synthases and the receptors in spinal cord following peripheral nerve injury. The 41th Annual Meeting of the Society for Neuroscience2011
- Author(s)
  Kanda H, Kobayashi K, Yamanaka H, Noguchi K
- Organizer
  The 41th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Washington DC
- Data Source
  KAKENHI-PROJECT-23500418
[Presentation] 腰部交感神経節ニューロンにおける電位依存性ナトリウムチャネルの発現と軸索切断後の変化2009
- Author(s)
  福岡哲男, 小林希実子, 山中博樹, 野口光一
- Organizer
  第31回日本疼痛学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] 末梢神経損傷後に脊髄で増加したロイコトリエンは神経因性疼痛に関与する2009
- Author(s)
  大久保正道, 山中博樹, 小林希実子, 野口光一
- Organizer
  第31回日本疼痛学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] 末梢神経損傷後に脊髄で合成が増加した血小板活性化因子は神経因性疼痛に関与する2009
- Author(s)
  大久保正道, 山中博樹, 小林希実子, 野口光一
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] Transient expression of TNF alpha in the rat spinal cord following peripheral nerve iujury.2009
- Author(s)
  Kobayashi K, Yamanaka, H., Okubo M, Dai Y, Noguchi K.
- Organizer
  The 39th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Chicago, U.S.A.
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] 末梢神経損傷後の脊髄後角マイクログリアで増加するp2受容体2009
- Author(s)
  小林希実子, 山中博樹, 大久保正道, 野口光一
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] 末梢神経損傷後に脊髄マイクログリアで増加するp2y受容体2009
- Author(s)
  小林希実子, 山中博樹, 大久保正道, 野口光一
- Organizer
  第31回日本疼痛学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] 末梢神経損傷後に脊髄で増加するP2Y受容体2009
- Author(s)
  小林希実子, 山中博樹, 野口光一
- Organizer
  第47回日本生物物理学会
- Place of Presentation
  徳島
- Year and Date
  2009-11-01
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] Platelet-activating factor biosynthesis in spinal cord contributes to neuropathic pain following peripheral nerve injury.2009
- Author(s)
  Okubo M, Yamanaka, H., Kobayashi K, Noguchi K.
- Organizer
  The 39th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Chicago, U.S.A.
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] ラット坐骨神経障害モデルにおけるERMの発現とリン酸化2009
- Author(s)
  樫本良亮, 山中博樹, 小林希実子, 大久保正道, 三村治, 野口光一
- Organizer
  第32回日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] Induction of annexin A2 in rat dorsal root ganglia and spinal cord following peripheral nerve iniury2008
- Author(s)
  Yamanaka, H., et.al.
- Organizer
  The 38th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Washington D. C.
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] 皮膚と後根神経節におけるロイコトリエン合成酵素および受容体の発現2008
- Author(s)
  大久保正道, 山中博樹, 小林希実子, 野口光一
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] Laminae-specific distribution of Nav mRNAs in the rat spinal cord2008
- Author(s)
  Fukuoka, T., Kobayashi, K., Yamanaka, H., Obata, K., Dai, Y., Noguchi, K.
- Organizer
  The 38th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Washington D.C., U.S.A.
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] Upregulation of leukotriene synthesis in glial cells contributes to neuropathic pain following peripheral nerve injury2008
- Author(s)
  Okubo, M., Yamanaka, H., Kobayashi, K., Noguchi, K.
- Organizer
  The 38th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Washington D.C., U.S.A.
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] 一次知覚ニューロンにおける電位依存性ナトリウムチャネルサブタイプの発現比較2008
- Author(s)
  福岡哲男, 小林希実子, 山中博樹, 戴毅, 小畑浩一, 野口光一
- Organizer
  第30回日本疼痛学会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] Induction of annexin A2 in rat dorsal root ganglia and spinal cord following peripheral nerve injury2008
- Author(s)
  Yamanaka, H., Okubo, M., Kobayashi, K., Noguchi, K.
- Organizer
  The 38th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Washington D.C., U.S.A.
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] ラット後根神経節におけるロイコトリエン受容体の発現2008
- Author(s)
  大久保正道, 山中博樹, 野口光一
- Organizer
  第57回(社)全日本鍼灸学会学術大会(京都大会)
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] Induction of P2Y receptor in the spinal cord following peripheral nerve injury2008
- Author(s)
  Kobayashi, K., Yamanaka, H., Fukuoka, T., Noguchi, K.
- Organizer
  The 38th Annual Meeting of the Society for Neuroscience
- Place of Presentation
  Washington D.C., U.S.A.
- Data Source
  KAKENHI-PROJECT-20790170
[Presentation] Alteration of the cell adhesion molecule CHL1 expression in a specific subset of primary afferent neurons and dorsal horn following nerve injury2007
- Author(s)
  Yamanaka, H., et. al.
- Organizer
  37th Annual Meeting Society for Neuroscience
- Place of Presentation
  San Diego, U.S.A.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500269
[Presentation] Alteration of the cell adhesion molecule CHL1 expression in a specific subset of primary afferent neurons and dorsal horn following nerve injury2007
- Author(s)
  Yamanaka, H., et. al.
- Organizer
  37th Annual Meeting Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-18021037
[Presentation] Alteration of the cell adhesion molecule CHL1 expression in a specific subset of primary afferent neurons and dorsal horn following nerve injury2007
- Author(s)
  Yamanaka, H., et. al.
- Organizer
  30th Annual Meeting of the Japan Neuroscience Society
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18500269
[Presentation] Alteration of the cell adhesion molecule CHL1 expression in a specific subset of primary afferent neurons and dorsal horn following nerve iniury2007
- Author(s)
  Yamanaka, H., et. al.
- Organizer
  37th Annual Meeting Society for Neuroscience
- Place of Presentation
  San Diego
- Data Source
  KAKENHI-PROJECT-19603020
[Presentation] Alteration of the cell adhesion molecule CHL1 expression in a specific subset of primary afferent neurons and dorsal horn following nerve injury2007
- Author(s)
  Yamanaka, H., et. al.
- Organizer
  37th Annual Meeting Society for Neuroscience
- Place of Presentation
  San Diego
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500269
[Presentation] 末梢神経損傷後の後根神経節および脊髄後角における細胞間接着因子CHL1の発現変化2007
- Author(s)
  山中博樹
- Organizer
  第30回日本神経科学大会
- Place of Presentation
  横浜
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18500269
[Presentation] 末梢神経損傷後の後根神経節および脊髄後角における細胞間接着因子CHL1の発現変化2007
- Author(s)
  山中博樹
- Organizer
  第30回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18021037
[Presentation] 末梢神経損傷後の後根神経節および脊髄後角における細胞間接着因子CHL1の発現変化2007
- Author(s)
  山中博樹
- Organizer
  第30回日本神経科学大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19603020

1. NOGUCHI Koichi (10212127)

# of Collaborated Projects: 7 results

# of Collaborated Products: 22 results
2. KOBAYASHI Kimiko (70418961)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. TOKUNAGA Atsushi (70254521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. DAI Yi (20330441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. FUKUOKA Tetsuo (90399147)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. YAGI Hideshi (10303372)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 清野大輔 (70449875)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 古賀浩平 (50768455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOGURE Yoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. TAGUCHI Toru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 山本悟史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 水村和枝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yamanaka Hiroki 山中 博樹

YAMANAKA Hiroki 山中 博樹

中山 博樹 ナカヤマ ヒロキ

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Co-Researchers

JNK活性による損傷c-fiber終末の形態的可塑性と疼痛への関与Principal Investigator

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Expression of neurotrypsin in dorsal root ganglia and dorsal horn following peripheral nerve injuryPrincipal Investigator

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Alpha2 delta-1 mediated synaptic plasticity in the dorsal horn of peripheral nerve injury model ratsPrincipal Investigator

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Involvement of phosphorylated L1-CAM in the plastic changes of nociecptive circuit following peripheral nerve injuryPrincipal Investigator

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A cell adhesion molecule close homologue of L1 increased in primary afferent terminal contributes to the development and maintenance of neuropathic painPrincipal Investigator

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Alteration of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic painPrincipal Investigator

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Yamanaka Hiroki 山中博樹

YAMANAKA Hiroki 山中博樹

中山博樹ナカヤマヒロキ