Sassa Takayuki 佐々貴之

… Alternative Names

SASSA Takayuki 佐々貴之

佐々貴之サッサタカユキ

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Researcher Number	20342793
Other IDs	https://orcid.org/0000-0003-3145-9829
External Links
Affiliation (Current)	2025: 九州産業大学, 生命科学部, 教授
Affiliation (based on the past Project Information) *help	2016 – 2024: 北海道大学, 薬学研究院, 准教授 2017: 北海道大学, 大学院薬学研究院, 准教授 2012 – 2014: 北海道大学, 薬学研究科(研究院), 講師 2013: 北海道大学, 大学院・薬学研究院, 講師 2010: 北海道大学, 大学院・薬学研究院, 講師 2003: 独立行政法人理化学研究所, 発生遺伝子制御研究チーム, 研究員 2002: 理化学研究所, 発生遺伝子制御研究チーム, 研究員
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Biological pharmacy / Neuroscience in general Except Principal Investigator Functional biochemistry
Keywords	Principal Investigator 脂質 / 極長鎖脂肪酸 / セラミド / 脂肪酸 / バリア / 皮膚バリア / 口腔粘膜 / 生体バリア / ELOVL1 / 消化管 … More / バリア機能 / ドライアイ / スフィンゴ脂質 / GFP / 顆粒細胞 / GAD / zic1 / 後脳 / プルキンエ細胞 / 小脳 / ゼブラフィッシュ … More Except Principal Investigator スフィンゴ脂質 / 極長鎖脂肪酸 / 脂肪酸 / 代謝 / 脂質 / 皮膚 / 生体膜 / 遺伝子 / バリア / 小胞体 / 蛋白質 / 生体分子 / 細胞・組織 / リポソーム / エンドソーム / 皮膚バリア機能 / 小胞輪送 / 小胞輸送 / ノックアウトマウス / 代謝異常 / 皮膚バリア / 3-ヒドロキシアシルCoA脱水酵素 / アシルCoA / 縮合酵素 / 脂質輸送 / ホスファチジルイノシトール / タンパク質 / 細胞内輸送 Less

Diversity and function of very-long-chain lipids in the formation of permeability barrierPrincipal Investigator
- Principal Investigator
  
  佐々貴之
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Hokkaido University
Distribution and function of very-long-chain lipids in the formation digestive duct barrier.Principal Investigator
- Principal Investigator
  
  SASSA TAKAYUKI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Hokkaido University
Study of very long-chain fatty acids using genetically modified mice.Principal Investigator
- Principal Investigator
  
  Sassa Takayuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Production and metabolism of very long-chain fatty acids and pathology due to their abnormal metabolism
- Principal Investigator
  
  KIHARA Akio
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Fatty acid elongase ELOVL1: function and diseasesPrincipal Investigator
- Principal Investigator
  
  SASSA Takayuki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Hokkaido University
Elucidation of the synthetic mechanism, disorders, and physiological functions of very long-chain fatty acids
- Principal Investigator
  
  KIHARA Akio
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
Elucidation of the mechanism of intracellular phosphatidylinositol trafficking by the Phs1 family
- Principal Investigator
  
  KIHARA Akio
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
ゼブラフィッシュ小脳プルキンエ細胞活動観察系の確立Principal Investigator
- Principal Investigator
  
  佐々貴之
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  The Institute of Physical and Chemical Research

[Journal Article] Relationship between time-dependent epidermal ceramide composition changes and skin barrier function in adult mice2025
- Author(s)
  Hiranuma Taiga, Sassa Takayuki, Kihara Akio
- Journal Title
  
  Molecular Biology of the Cell
  
  Volume: 36 Issue: 5
- DOI
  10.1091/mbc.e24-12-0551
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H04986, KAKENHI-PROJECT-23K24020
[Journal Article] Comparison of skin barrier abnormalities and epidermal ceramide profiles among three ω-O-acylceramide synthesis-deficient mouse strains2024
- Author(s)
  Yamamoto Yuta, Sassa Takayuki, Kihara Akio
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 113 Issue: 1 Pages: 10-17
- DOI
  10.1016/j.jdermsci.2023.12.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H04986, KAKENHI-PROJECT-23K24020
[Journal Article] Importance of ceramides containing very-long-chain fatty acids in oral barrier function2024
- Author(s)
  佐々貴之
- Journal Title
  
  生化学
  
  Volume: 96 Issue: 1 Pages: 60-65
- DOI
  10.14952/SEIKAGAKU.2024.960060
- ISSN
  0037-1017
- Year and Date
  2024-02-25
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K24020
[Journal Article] Involvement of ω-O-acylceramides and protein-bound ceramides in oral permeability barrier formation2023
- Author(s)
  Sassa Takayuki, Kihara Akio
- Journal Title
  
  Cell Reports
  
  Volume: 42 Issue: 4 Pages: 112363-112363
- DOI
  10.1016/j.celrep.2023.112363
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04986, KAKENHI-PROJECT-23K24020
[Journal Article] Incomplete elongation of ultra-long-chain polyunsaturated acyl-CoAs by the fatty acid elongase ELOVL4 in spinocerebellar ataxia type 342023
- Author(s)
  Tamura Yuka, Sassa Takayuki, Nishizawa Takumi, Kihara Akio
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 43 Issue: 2 Pages: 85-101
- DOI
  10.1080/10985549.2023.2169563
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22H04986, KAKENHI-PROJECT-23K24020
[Journal Article] Hypomyelinating spastic dyskinesia and ichthyosis caused by a homozygous splice site mutation leading to exon skipping in ELOVL12022
- Author(s)
  Takahashi Taiko, Mercan Sevcan, Sassa Takayuki, Akcapinar Gunseli Bayram, Yararbas Kanay, Susgun Seda, Iseri Sibel Aylin Ugur, Kihara Akio, Akcakaya Nihan Hande
- Journal Title
  
  Brain and Development
  
  Volume: 44 Issue: 6 Pages: 391-400
- DOI
  10.1016/j.braindev.2022.03.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22H04986, KAKENHI-PROJECT-23K24020
[Journal Article] Ceramide profiling of stratum corneum in Sjogren-Larsson syndrome2022
- Author(s)
  Arai Ayami, Takeichi Takuya, Wakamoto Hiroyuki, Sassa Takayuki, Ito Yasutoshi, Murase Yuya, Ogi Tomoo, Akiyama Masashi, Kihara Akio
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 107 Issue: 3 Pages: 114-122
- DOI
  10.1016/j.jdermsci.2022.08.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22H04986, KAKENHI-PROJECT-23K24020, KAKENHI-PROJECT-20H00629, KAKENHI-PROJECT-21H02941
[Journal Article] Comprehensive stratum corneum ceramide profiling reveals reduced acylceramides in ichthyosis patient with CERS3 mutations2021
- Author(s)
  Yamamoto Moe、Sassa Takayuki、Kyono Yuki、Uemura Hiroyasu、Kugo Masaaki、Hayashi Hideki、Imai Yasutomo、Yamanishi Kiyofumi、Kihara Akio
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 48 Issue: 4 Pages: 447-456
- DOI
  10.1111/1346-8138.15725
- NAID
  120007186306
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07060, KAKENHI-PROJECT-18H03976
[Journal Article] Diverse meibum lipids produced by Awat1 and Awat2 are important for stabilizing tear film and protecting the ocular surface2021
- Author(s)
  Sawai Megumi、Watanabe Keisuke、Tanaka Kana、Kinoshita Wataru、Otsuka Kento、Miyamoto Masatoshi、Sassa Takayuki、Kihara Akio
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 5 Pages: 102478-102478
- DOI
  10.1016/j.isci.2021.102478
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07060, KAKENHI-PROJECT-19J22148
[Journal Article] Protein‐bound ceramide levels in the epidermis of transglutaminase 1‐deficient mice2021
- Author(s)
  Sassa Takayuki、Imai Yasutomo、Kihara Akio、Yamanishi Kiyofumi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 48 Issue: 11 Pages: 1799-1801
- DOI
  10.1111/1346-8138.16113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07060, KAKENHI-PROJECT-18H03976
[Journal Article] Impaired Skin Barrier Function Due to Reduced ω-O-Acylceramide Levels in a Mouse Model of Sjogren-Larsson Syndrome2021
- Author(s)
  Nojiri Koki、Fudetani Shuhei、Arai Ayami、Kitamura Takuya、Sassa Takayuki、Kihara Akio
- Journal Title
  
  Molecular and Cellular Biology
  
  Volume: 41 Issue: 10
- DOI
  10.1128/mcb.00352-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07060, KAKENHI-PROJECT-18H03976
[Journal Article] Production of branched-chain very-long-chain fatty acids by fatty acid elongases and their tissue distribution in mammals2021
- Author(s)
  Tanno Honoka, Sassa Takayuki, Sawai Megumi, Kihara Akio
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  
  Volume: 1866 Issue: 1 Pages: 158842-158842
- DOI
  10.1016/j.bbalip.2020.158842
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03976, KAKENHI-PROJECT-19K07060
[Journal Article] Improvement of Evaporative Dry Eye With Meibomian Gland Dysfunction in Model Mice by Treatment With Ophthalmic Solution Containing Mineral Oil2021
- Author(s)
  Watanabe Keisuke、Yoshida Masataka、Okumura Takashi、Sassa Takayuki、Kihara Akio、Uchiyama Akira
- Journal Title
  
  Translational Vision Science & Technology
  
  Volume: 10 Issue: 4 Pages: 21-21
- DOI
  10.1167/tvst.10.4.21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07060
[Journal Article] Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease2020
- Author(s)
  Miyamoto Masatoshi、Sassa Takayuki、Sawai Megumi、Kihara Akio
- Journal Title
  
  eLife
  
  Volume: 9
- DOI
  10.7554/elife.53582
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07060, KAKENHI-PROJECT-18H03976
[Journal Article] Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production2020
- Author(s)
  Miyamoto Masatoshi、Itoh Narumi、Sawai Megumi、Sassa Takayuki、Kihara Akio
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 140 Issue: 2 Pages: 319-326
- DOI
  10.1016/j.jid.2019.07.689
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07060, KAKENHI-PUBLICLY-18H04664, KAKENHI-PROJECT-18H03976
[Journal Article] Novel biallelic FA2H mutations in a Japanese boy with fatty acid hydroxylase-associated neurodegeneration2020
- Author(s)
  Kawaguchi Masahiro、Sassa Takayuki、Kidokoro Hiroyuki、Nakata Tomohiko、Kato Kohji、Muramatsu Hideki、Okuno Yusuke、Yamamoto Hiroyuki、Kaname Tadashi、Kihara Akio、Natsume Jun
- Journal Title
  
  Brain and Development
  
  Volume: 42 Issue: 2 Pages: 217-221
- DOI
  10.1016/j.braindev.2019.11.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07863, KAKENHI-PROJECT-19K07060, KAKENHI-PROJECT-17K10075
[Journal Article] De novo mutation in ELOVL1 causes ichthyosis, acanthosis nigricans, hypomyelination, spastic paraplegia, high frequency deafness and optic atrophy2019
- Author(s)
  Mueller Noomi, Sassa Takayuki, Morales-Gonzalez Susanne, Schneider Joanna, Salchow Daniel J, Seelow Dominik, Knierim Ellen, Stenzel Werner, Kihara Akio, Schuelke Markus
- Journal Title
  
  Journal of Medical Genetics
  
  Volume: 56 Issue: 3 Pages: 164-175
- DOI
  10.1136/jmedgenet-2018-105711
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04664, KAKENHI-PROJECT-16K08220
[Journal Article] Reduced chain length in myelin sphingolipids and poorer motor coordination in mice deficient in the fatty acid elongase Elovl12019
- Author(s)
  Isokawa Masashi、Sassa Takayuki、Hattori Satoko、Miyakawa Tsuyoshi、Kihara Akio
- Journal Title
  
  FASEB BioAdvances
  
  Volume: 1 Issue: 12 Pages: 747-759
- DOI
  10.1096/fba.2019-00067
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07400, KAKENHI-PROJECT-19K07060, KAKENHI-PUBLICLY-18H04664, KAKENHI-PROJECT-18H03976, KAKENHI-PROJECT-16H06276
[Journal Article] Very long-chain tear film lipids produced by fatty acid elongase ELOVL1 prevent dry eye disease in mice2018
- Author(s)
  Sassa T, Tadaki M, Kiyonari H, Kihara A
- Journal Title
  
  FASEB J.
  
  Volume: 印刷中 Issue: 6 Pages: 2966-2978
- DOI
  10.1096/fj.201700947r
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-16K08220
[Journal Article] Decreased Skin Barrier Lipid Acylceramide and Differentiation-Dependent Gene Expression in Ichthyosis Gene Nipal4-Knockout Mice.2018
- Author(s)
  Honda Y, Kitamura T, Naganuma T, Abe T, Ohno Y, Sassa T, Kihara A
- Journal Title
  
  J. Invest. Dermatol.
  
  Volume: 138 Issue: 4 Pages: 741-749
- DOI
  10.1016/j.jid.2017.11.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08220, KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-15H05589, KAKENHI-PROJECT-17K15452
[Journal Article] The 3-hydroxyacyl-CoA dehydratases HACD1 and HACD2 exhibit functional redundancy and are active in a wide range of fatty acid elongation pathways.2017
- Author(s)
  Sawai M, Uchida Y, Ohno Y, Miyamoto M, Nishioka C, Itohara S, Sassa T, Kihara A
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 292 Issue: 37 Pages: 11538-11551
- DOI
  10.1074/jbc.m117.803171
- NAID
  120006517686
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08220, KAKENHI-PROJECT-26251010
[Journal Article] Disruption of the Sjogren-Larsson syndrome gene Aldh3a2 in mice increases keratinocyte growth and retards skin barrier recovery2016
- Author(s)
  Tatsuro Naganuma, Shuyu Takagi, Tsukasa Kanetake, Takuya Kitamura, Satoko Hattori, Tsuyoshi Miyakawa, Takayuki Sassa, Akio Kihara
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 印刷中 Issue: 22 Pages: 11676-11688
- DOI
  10.1074/jbc.m116.714030
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J00744, KAKENHI-PROJECT-14J02202, KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-16H06276
[Journal Article] Enzyme activities of the ceramide synthases CERS2-6 are regulated by phosphorylation in the C-terminal region2016
- Author(s)
  Sassa T, Hirayama T, Kihara A
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 291 Issue: 14 Pages: 7477-7487
- DOI
  10.1074/jbc.m115.695858
- NAID
  120006024351
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26251010, KAKENHI-PROJECT-16K08220
[Journal Article] Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid2014
- Author(s)
  Sassa T, Wakashima T, Ohno Y, Kihara A
- Journal Title
  
  Journal of lipid research
  
  Volume: 55 Issue: 3 Pages: 524-530
- DOI
  10.1194/jlr.m044586
- NAID
  120005457018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-24590073
[Journal Article] Lorenzo's oil inhibits ELOVL1 and lowers the level of sphingomyelin with a saturated very long-chain fatty acid2014
- Author(s)
  Sassa T, Wakashima T, Ohno Y, Kihara A
- Journal Title
  
  J. Lipid Res.
  
  Volume: 55 Pages: 524-530
- NAID
  120005457018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] Metabolism of very long-chain fatty acids : genes and pathophysiology2014
- Author(s)
  Sassa T, Kihara A
- Journal Title
  
  Biomol. Ther
  
  Volume: 22 Issue: 2 Pages: 83-92
- DOI
  10.4062/biomolther.2014.017
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-24590073
[Journal Article] Cooperative synthesis of ultra long-chain fatty acid and ceramide during keratinocyte differentiation.2013
- Author(s)
  Mizutani Y, Sun, H Ohno Y, Sassa T, Wakashima T, Obara M, Yuyama K, Kihara A and Igarashi Y.
- Journal Title
  
  PLoS One
  
  Volume: 8
- NAID
  120005322424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590073
[Journal Article] Impaired epidermal permeability barrier in mice lacking the Elovl1 gene responsible for very long-chain fatty acid production.2013
- Author(s)
  Sassa T, Ohno Y, Suzuki S, Nomura T, Nishioka C, Kashiwagi T, Hirayama T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 33 Issue: 14 Pages: 2787-2796
- DOI
  10.1128/mcb.00192-13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249058, KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-24390152, KAKENHI-PROJECT-24590073, KAKENHI-PROJECT-24619007, KAKENHI-PROJECT-24659526, KAKENHI-PROJECT-25670494
[Journal Article] Mutation for nonsyndromic mental retardation in the trans-2-enoyl-CoA reductase TER gene involved in fatty acid elongation impairs the enzyme activity and stability, leading to change in sphingolipid profile2013
- Author(s)
  Abe K, Ohno Y, Sassa T, Taguchi R, Çali şkan, M, Ober C, Kihara A
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 51 Pages: 36741-36749
- DOI
  10.1074/jbc.m113.493221
- NAID
  120005385316
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057, KAKENHI-PROJECT-24590073, KAKENHI-PROJECT-24619007, KAKENHI-PUBLICLY-25116701, KAKENHI-PROJECT-25870001
[Journal Article] Cooperative synthesis of ultra long-chain fatty acid and ceramide during keratinocyte differentiation2013
- Author(s)
  Mizutani Y, Sun H, Ohno Y, Sassa T, Wakashima T, Obara M, Yuyama K, Kihara A, Igarashi Y
- Journal Title
  
  PLos One
  
  Volume: 8 Issue: 6 Pages: e67317-e67317
- DOI
  10.1371/journal.pone.0067317
- NAID
  120005322424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] A shift in sphingolipid composition from C24 to C16 increases susceptibility to apoptosis in HeLa cells2012
- Author(s)
  Sassa T, Suto S, Okayasu Y, Kihara A
- Journal Title
  
  Biochim. Biophys. Acta
  
  Volume: 1821 Issue: 7 Pages: 1031-1037
- DOI
  10.1016/j.bbalip.2012.04.008
- NAID
  120005946698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] Biochemical characterization of the very long-chain fatty acid elongase ELOVL72011
- Author(s)
  Naganuma T, Sato Y, Sassa T, Ohno Y, Kihara A
- Journal Title
  
  FEBS Lett
  
  Volume: 585 Issue: 20 Pages: 3337-3341
- DOI
  10.1016/j.febslet.2011.09.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370057
[Journal Article] ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.2010
- Author(s)
  Ohno, Y., Suto, S., Yamanaka, M., Mizutani, Y., Mitsutake, S., Igarashi, Y., Sassa, T., Kihara, A.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 107
  
  Pages: 18439-18444
- NAID
  120002934261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20687008
[Presentation] 脂肪族アシルCoA還元酵素FAR1のセミノリピド合成と精子形成における役割2024
- Author(s)
  玉澤彩乃, 永沼達郎, 大塚賢人, 佐々貴之（発表者）, 木原章雄
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24020
[Presentation] 成体マウスにおける脂肪酸伸長酵素遺伝子Elovl1の欠損によるアシルセラミドおよび結合型セラミド量の変化と皮膚バリア機能の関係2024
- Author(s)
  平沼大雅, 佐々貴之, 木原章雄
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24020
[Presentation] 脂肪酸伸長酵素 ELOVL1 の欠損による時間依存的マイバム脂質組成変化とドライアイの進行2024
- Author(s)
  多田向日葵, 城島啓佑, 平沼大雅, 佐々貴之, 木原章雄
- Organizer
  第66回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-23K24020
[Presentation] 脂肪酸伸長酵素遺伝子ELOVL1欠損による時間依存的表皮セラミド組成変化と皮膚バリア機能の関係2024
- Author(s)
  平沼大雅, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部第151例会
- Data Source
  KAKENHI-PROJECT-23K24020
[Presentation] 顕性遺伝性皮膚神経疾患を引き起こす脂肪酸伸長酵素ELOVL1変異体の解析2024
- Author(s)
  牧優香, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部第151例会
- Data Source
  KAKENHI-PROJECT-23K24020
[Presentation] ３系統のアシルセラミド合成遺伝子ノックアウトマウスにおける皮膚バリア不全と表皮セラミドプロファイルの比較2024
- Author(s)
  山本祐太, 佐々貴之（発表者）, 木原章雄
- Organizer
  第17回セラミド研究会学術集
- Data Source
  KAKENHI-PROJECT-23K24020
[Presentation] エーテルリン脂質生合成に関わる新規1-O-アルキルジヒドロキシアセトンリン酸還元酵素の同定2024
- Author(s)
  髙橋典雅, 佐々貴之, 木原章雄
- Organizer
  第97回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24020
[Presentation] 神経系における長鎖脂肪族アルコール産生酵素FAR1の機能2023
- Author(s)
  髙橋典雅, 大塚賢人, 佐々貴之, 木原章雄
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24020
[Presentation] ELOVL4ミスセンス変異による脊髄小脳失調症34型における超長鎖多価不飽和脂肪酸の不完全伸長2023
- Author(s)
  田村優花, 佐々貴之（発表者）, 西澤卓海, 木原章雄
- Organizer
  第 65 回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-23K24020
[Presentation] 皮膚バリアの維持におけるアシルセラミド及び結合型セラミドの役割2023
- Author(s)
  平沼大雅, 佐々貴之, 木原章雄
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-23K24020
[Presentation] 口腔バリア形成へのセラミドの関与2023
- Author(s)
  佐々貴之, 木原章雄
- Organizer
  第16回セラミド研究会学術集会，第17回スフィンゴテラピィ研究会合同年会
- Data Source
  KAKENHI-PROJECT-23K24020
[Presentation] セミノリピド合成と精子形成における脂肪族アシルCoA還元酵素FAR1の役割およびセミノリピドとスルファチドの精巣におけるアシル／アルキル鎖の多様性2023
- Author(s)
  玉澤彩乃, 大塚賢人, 佐々貴之, 木原章雄
- Organizer
  第16回セラミド研究会学術集会，第17回スフィンゴテラピィ研究会合同年会
- Data Source
  KAKENHI-PROJECT-23K24020
[Presentation] マイバム脂質中のステリルエステルにおけるステロール多様性2022
- Author(s)
  木下航, 宮本政宗, 佐々貴之, 木原章雄
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K24020
[Presentation] ELOVL4遺伝子変異による脳神経疾患SCA34およびISQMRの発症メカニズム解明2022
- Author(s)
  田村優花, 佐々貴之, 木原章雄
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] 脂肪酸伸長酵素ELOVLにより産生される極長鎖脂肪酸の多様な機能2022
- Author(s)
  佐々貴之, 木原章雄
- Organizer
  第43回生体膜と薬物の相互作用シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K24020
[Presentation] アシルセラミド／結合型セラミドによる口腔粘膜上皮バリア形成2021
- Author(s)
  佐々貴之, 木原章雄
- Organizer
  第94回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] アシルセラミド／結合型セラミドは口腔粘膜上皮の物質透過性バリア形成に関わる2021
- Author(s)
  佐々貴之, 木原章雄
- Organizer
  第14回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] マイバム脂質中のステロールエステルにおけるステロール多様性2021
- Author(s)
  木下航, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部148回例会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] アシル基転移酵素 Awat1 および Awat2 が生み出すマイバム脂質多様性とドライアイ防止における役割2021
- Author(s)
  澤井恵, 木下航, 大塚賢人, 宮本政宗, 佐々貴之, 木原章雄
- Organizer
  第63回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] 皮膚バリア脂質アシルセラミド／結合型セラミドの口腔および食道の粘膜上皮における存在と機能2021
- Author(s)
  佐々貴之, 木原章雄
- Organizer
  第63回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] 新規ELOVL1変異を持つ魚鱗癬患者の角質層の包括的セラミドプロファイリング2020
- Author(s)
  髙橋多衣子, 佐々貴之, 木原章雄
- Organizer
  第13回セラミド研究会学術集会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] 極長鎖分岐鎖脂肪酸の伸長と代謝及び組織分布の解明2020
- Author(s)
  丹野歩乃佳, 佐々貴之, 澤井恵, 木原章雄
- Organizer
  第19回次世代を担うファーマ・バイオフォーラム2020
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] 極長鎖スフィンゴ脂質の短鎖化によるミエリン厚低下と協調運動障害2020
- Author(s)
  佐々貴之, 磯川昌志, 服部聡子, 宮川剛, 木原章雄
- Organizer
  先端モデル動物支援プラットフォーム成果発表会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] 魚鱗癬を引き起こすセラミド合成酵素CERS3変異の活性および角質層セラミド組成への影響2020
- Author(s)
  山本萌恵, 佐々貴之, 京野由紀, 上村裕保, 久呉真章, 林秀樹, 今井康友, 山西清文, 木原章雄
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] アシル基転移酵素Awat1および2が産生する多様なエステル分子種によるドライアイ防止2020
- Author(s)
  澤井恵, 大塚賢人, 宮本政宗, 丹野歩乃佳, 佐々貴之, 木原章雄
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] 魚鱗癬を引き起こすセラミド合成酵素CERS3変異の活性および角質層セラミド組成への影響2020
- Author(s)
  山本萌恵, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部147回例会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] ω水酸化脂質による涙液油層中の極性勾配形成がドライアイを防止する2020
- Author(s)
  宮本政宗, 佐々貴之, 澤井恵, 木原章雄
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] アシル基転移酵素Awat1および2が生み出す多様なエステル分子種と涙液油層における役割2020
- Author(s)
  澤井恵, 大塚賢人, 宮本政宗, 丹野歩乃佳, 佐々貴之, 木原章雄
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] シェーグレン・ラルソン症候群皮膚病態モデルマウスの確立と病態発症機構の解明2019
- Author(s)
  野尻光希, 筆谷周平, 佐々貴之, 木原章雄
- Organizer
  第61回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] 分岐鎖脂肪酸の伸長と組織分布の解明2019
- Author(s)
  丹野歩乃佳, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部146回例会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] 極長鎖脂質による体表バリアの形成2019
- Author(s)
  佐々貴之, 木原章雄
- Organizer
  第61回日本脂質生化学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] Very-long-chain lipids function as barrier lipids.2019
- Author(s)
  Sassa T
- Organizer
  The 10th Annual Congress of Pan Asian-Pacific Skin Barrier Research Society
- Invited
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] 分岐鎖脂肪酸の伸長酵素および組織分布の解明2019
- Author(s)
  丹野歩乃佳, 佐々貴之, 木原章雄
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] Acylceramide production and skin barrier formation by the fatty acid omega-hydroxylase CYP4F22/Cyp4f39.2019
- Author(s)
  Itoh N, Ohno Y, Sassa T, Kihara A
- Organizer
  FEBS Special Meeting on Sphingolipid Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] Establishment of Sjogren-Larsson syndrome model mouse leading to elucidation of the skin pathogenesis mechanism.2019
- Author(s)
  Nojiri K, Fudetani S, Sassa T, Kihara A
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] Very long-chain lipids produced by the fatty acid elongase ELOVL1 are important for myelin formation and motor coordination.2019
- Author(s)
  Sassa T, Isokawa M, Kihara A
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] Decreases in chain lengths and level of myelin sphingolipids are associated with hypomyelination and deficient motor coordination in mice lacking fatty acid elongase ELOVL1.2019
- Author(s)
  Sassa T, Isokawa M, Kihara A
- Organizer
  第42回日本神経科学大会・第62回日本神経化学会大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07060
[Presentation] 涙液に含まれる極長鎖ワックスエステルの合成機構と生理機能の解明2018
- Author(s)
  澤井恵, 只木雅人, 佐々貴之, 木原章雄
- Organizer
  第60回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-16K08220
[Presentation] Pathological mechanism of congenital ichthyosis revealed by analyses of ichthyosis-causative gene knockout mice.2018
- Author(s)
  Sassa T, Ohno Y, Kihara A.
- Organizer
  Fall International Convention of The Pharmaceutical Society of Korea
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08220
[Presentation] 涙液バリア形成に重要な極長鎖ワックスエステルの生合成経路の解明2018
- Author(s)
  澤井恵, 只木雅人, 佐々貴之, 木原章雄
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-16K08220
[Presentation] 涙液バリア機能を担う極長鎖ワックスエステルの合成機構の解明2018
- Author(s)
  澤井恵, 只木雅人, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部145回例会
- Data Source
  KAKENHI-PROJECT-16K08220
[Presentation] Very long-chain lipids as barrier lipids at the body surface.2018
- Author(s)
  Sassa T, Kihara A
- Organizer
  2nd Japan-Korea Lipid Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08220
[Presentation] マウスCYP4F39による超長鎖脂肪酸のω位水酸化はアシルセラミド産生および皮膚バリア形成に必須である2017
- Author(s)
  伊藤成美, 佐々貴之, 木原章雄
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] シェーグレン・ラルソン症候群モデルマウスにおけるミエリン脂質2-ヒドロキシガラクトシルセラミドの低下2017
- Author(s)
  野尻光希, 金武司, 佐々貴之, 木原章雄
- Organizer
  第16回次世代を担うファーマ・バイオフォーラム2017
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 魚鱗癬原因遺伝子NIPAL4の欠損によるアシルセラミド産生低下と皮膚バリア機能異常2017
- Author(s)
  本多湧一, 北村拓也, 永沼達郎, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  第16回次世代を担うファーマ・バイオフォーラム2017
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 脂肪酸2位水酸化酵素FA2H機能低下によるシェーグレン・ラルソン症候群の神経症状発症.2017
- Author(s)
  野尻光希, 金武司, 佐々貴之, 木原章雄
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K08220
[Presentation] 極長鎖脂肪酸／脂肪族アルコール含有マイバム脂質は涙液のバリア機能に必須である2017
- Author(s)
  佐々貴之, 只木雅人, 木原章雄
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 魚鱗癬原因遺伝子Nipal4ノックアウトマウスにおける皮膚バリア脂質アシルセラミドの減少.2017
- Author(s)
  本多湧一, 北村拓也, 永沼達郎, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K08220
[Presentation] マウスCYP4F39による超長鎖脂肪酸のω位水酸化はアシルセラミド産生および皮膚バリア形成に必須である.2017
- Author(s)
  伊藤成美, 佐々貴之, 木原章雄
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K08220
[Presentation] 極長鎖脂肪酸／脂肪族アルコール含有マイバム脂質は涙液のバリア機能に必須である.2017
- Author(s)
  佐々貴之, 只木雅人, 木原章雄
- Organizer
  第59回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-16K08220
[Presentation] ミオパチー原因遺伝子HACD1の生理機能と基質特異性の解析2017
- Author(s)
  澤井恵, 内田有紀子, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] ミオパチー原因遺伝子HACD1の生理機能と基質特異性の解析．2017
- Author(s)
  澤井恵, 内田有紀子, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16K08220
[Presentation] 脂肪酸伸長サイクル不全によるミオパチー発症の分子機構およびHACDの基質特異性の解析2017
- Author(s)
  澤井恵, 内田有紀子, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部144回例会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 魚鱗癬原因遺伝子Nipal4ノックアウトマウスにおける皮膚バリア脂質アシルセラミドの減少2017
- Author(s)
  本多湧一, 北村拓也, 永沼達郎, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] シェーグレン・ラルソン症候群の神経症状発症メカニズムの解明2017
- Author(s)
  野尻光希, 金武司, 佐々貴之, 木原章雄
- Organizer
  日本生化学会北海道支部第54回支部例会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 脂肪酸2位水酸化酵素FA2H機能低下によるシェーグレン・ラルソン症候群の神経症状発症2017
- Author(s)
  野尻光希, 金武司, 佐々貴之, 木原章雄
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 脂肪酸2位水酸化酵素FA2H機能低下によるシェーグレン・ラルソン症候群の神経症状発症2017
- Author(s)
  野尻光希, 金武司, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部144回例会
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 涙液バリア形成に必須なマイバム脂質産生の分子機構の解明2016
- Author(s)
  只木雅人, 佐々貴之, 木原章雄
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター／東北大学川内北キャンパス（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Decrease in 2-hydroxygalactosylceramide and impairment in behavioral tests in Aldh3a2 knockout mice2016
- Author(s)
  Sassa T, Kanetake T, Takagi S, Nojiri K, Naganuma T, Kitamura T, Kihara A
- Organizer
  57th International Conference on the Bioscience of Lipids
- Place of Presentation
  シャモニー（フランス）
- Year and Date
  2016-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] セラミド合成酵素CERS2-6のリン酸化による活性制御2016
- Author(s)
  佐々貴之, 平山泰佑, 原田由貴, 木原章雄
- Organizer
  第58回日本脂質生化学会
- Place of Presentation
  秋田市にぎわい交流館AU（秋田県秋田市）
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] 涙液バリア形成に必須なマイバム脂質産生の分子機構の解明2016
- Author(s)
  只木雅人，佐々貴之，木原章雄
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-26
- Data Source
  KAKENHI-PROJECT-16K08220
[Presentation] ドライアイ防止に関わるマイバム脂質の産生機構の解明2016
- Author(s)
  只木雅人, 佐々貴之, 木原章雄
- Organizer
  日本生化学会北海道支部第53回支部例会
- Place of Presentation
  北海道大学（北海道札幌市）
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] セラミド合成酵素CERS2-6のリン酸化による活性制御2016
- Author(s)
  佐々貴之, 平山泰佑, 原田由貴，木原章雄
- Organizer
  第58回脂質生化学会
- Place of Presentation
  秋田市にぎわい交流館AU（秋田県秋田市）
- Year and Date
  2016-06-10
- Data Source
  KAKENHI-PROJECT-16K08220
[Presentation] シェーグレン・ラルソン症候群モデルマウスを用いた病態のメカニズム解析2016
- Author(s)
  木原章雄, 永沼達郎, 金武司, 佐々貴之
- Organizer
  第11回スフィンゴテラピィ研究会
- Place of Presentation
  ホテルアローレ（石川県河北郡）
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] Retarded skin barrier recovery and an increased keratinocyte growth in Sjogren-Larsson syndrome gene Aldh3a2 knockout mice2016
- Author(s)
  Naganuma T, Takagi S, Kanetake T, Kitamura T, Sassa T, Kihara A
- Organizer
  1st Korea-Japan Bioactive Lipid Joint Symposium
- Place of Presentation
  チェジュ（韓国）
- Year and Date
  2016-05-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] ドライアイ防止に関わるマイバム脂質の産生機構の解明2016
- Author(s)
  只木雅人，佐々貴之，木原章雄
- Organizer
  日本生化学会北海道支部第53回支部例会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2016-07-08
- Data Source
  KAKENHI-PROJECT-16K08220
[Presentation] Aldh3a2 knockout mice as a potential model for Sjogren-Larsson syndrome.2015
- Author(s)
  Sassa T, Kanetake T, Naganuma T, Takagi S, Kitamura T and Kihara A
- Organizer
  6th International Conference on Phospholipase A2 and Lipid Mediators (PLM2015)
- Place of Presentation
  Keio Plaza Hotel, Shinjuku, Tokyo
- Year and Date
  2015-02-15
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] Regulation of mammalian ceramide synthases by phosphorylation2015
- Author(s)
  Sassa T, Hirayama T, Kihara A
- Organizer
  International Conference of the Korean Society for Molecular and Cellular Biology 2015
- Place of Presentation
  ソウル（韓国）
- Year and Date
  2015-09-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] リン酸化によるセラミド合成酵素の活性制御2015
- Author(s)
  佐々貴之, 平山泰祐, 木原章雄
- Organizer
  第8回セラミド研究会学術集会
- Place of Presentation
  北海道大学学術交流会館（北海道札幌市）
- Year and Date
  2015-10-29
- Data Source
  KAKENHI-PROJECT-26251010
[Presentation] シェーグレン・ラルソン症候群原因遺伝子Aldh3a2 KOマウスを用いた脳における生化学的解析2014
- Author(s)
  金武司, 佐々貴之, 高木秀侑, 永沼達郎, 木原章雄
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会議場，京都
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] C24極長鎖脂肪酸の生理機能と病態への関与2014
- Author(s)
  佐々貴之
- Organizer
  第7回セラミド研究会学術集会
- Place of Presentation
  東京ユビキタス協創広場 CANVAS，東京
- Year and Date
  2014-10-31
- Invited
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] シェーグレン・ラルソン症候群原因遺伝子Aldh3a2の欠損はマウスケラチノサイトにおいて細胞増殖の亢進とアシルセラミド量の低下を引き起こす2014
- Author(s)
  永沼達郎, 高木秀侑, 金武司, 北村拓也, 佐々貴之, 木原章雄
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会議場，京都
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] シェーグレン・ラルソン症候群原因遺伝子ALDH3A2の表皮における機能解析2014
- Author(s)
  高木秀侑, 永沼達郎, 金武司, 北村拓也, 佐々貴之, 木原章雄
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会議場，京都
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] シェーグレン・ラルソン症候群原因遺伝子Aldh3a2ノックアウトマウスを用いた神経症状発症の分子機構の解析2014
- Author(s)
  佐々貴之, 金武司, 高木秀侑, 永沼達郎, 木原章雄
- Organizer
  第56回日本脂質生化学会
- Place of Presentation
  近畿大学，大阪
- Year and Date
  2014-06-07
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] シェーグレン・ラルソン症候群における皮膚魚鱗癬発症メカニズムの解析2014
- Author(s)
  永沼達郎, 高木秀侑, 金武司, 北村拓也, 佐々貴之, 木原章雄
- Organizer
  日本生化学会北海道支部第51回支部例会
- Place of Presentation
  北海道大学百年記念会館，札幌
- Year and Date
  2014-07-18
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] Fatty acid elongase Elovl1 is essential for the synthesis of ≧C26 ceramides and epidermal permeability barrier formation2014
- Author(s)
  Sassa T, Ohno Y, Suzuki S, Nomura T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A
- Organizer
  Gordon Research Conference (Glycolipid & Sphingolipid Biology)
- Place of Presentation
  Four Points Sheraton, Ventura, USA
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] シェーグレン・ラルソン症候群原因遺伝子Aldh3a2の中枢神経系における機能解析2014
- Author(s)
  金武司, 佐々貴之, 高木秀侑, 永沼達郎, 木原章雄
- Organizer
  日本薬学会北海道支部141回例会
- Place of Presentation
  札幌コンベンションセンター，札幌
- Year and Date
  2014-05-24
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] Mice lacking the Elovl1 gene responsible for very long-chain fatty acid production exhibit neonatal lethality due to impaired epidermal permeability barrier.2013
- Author(s)
  Sassa T, Ohno Y, Suzuki S, Nomura T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A.
- Organizer
  FASEB Summer Research conferences (Lysophospholipid and Other Related Mediators - From Bench to Clinic)
- Place of Presentation
  Hilton Niseko Village, Niseko, Japan
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] 極長鎖脂肪酸伸長酵素Elovl1は表皮において層特異的な制御を受け皮膚バリアに必須の役割を果たす2013
- Author(s)
  佐々貴之, 大野祐介, 鈴木翔多朗, 乃村俊史, 秋山真志, 田口良, 清水宏, 糸原重美, 木原章雄
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] 家族性精神遅滞に見られるTER P182L変異体の生化学的解析2013
- Author(s)
  安部健介, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  日本薬学会北海道支部140回例会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] Mice lacking the Elovl1 gene responsible for very long-chain fatty acid production exhibit neonatal lethality due to impaired epidermal permeability barrier2013
- Author(s)
  Sassa T, Ohno Y, Suzuki S, Nomura T, Akiyama M, Taguchi R, Shimizu H, Itohara S, Kihara A
- Organizer
  FASEB Summer Research conferences (Lysophospholipid and Other Related Mediators - From Bench to Clinic)
- Place of Presentation
  ヒルトンニセコビレッジ（北海道）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] 常染色体劣性遺伝精神遅滞に見られるTER P182L変異体の生化学的解析2013
- Author(s)
  安部健介, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  第55回日本脂質生化学会
- Place of Presentation
  ホテル松島大観荘（仙台市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] 家族性精神遅滞原因遺伝子TER P182L変異体の生化学的解析とスフィンゴ脂質代謝への影響について2013
- Author(s)
  安部健介, 大野祐介, 佐々貴之, 木原章雄
- Organizer
  第6回セラミド研究会学術集会
- Place of Presentation
  北海道大学学術交流会館（札幌市）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] Loss of ELOVL1 enzyme causes lethal skin barrier disruption in mice.2013
- Author(s)
  Suzuki S, Nomura T, Sassa T, Ohno Y, Nakamura H, Akiyama M, Kihara A and Shimizu H.
- Organizer
  40th Annual Meeting of Society for Cutaneous Ultrastructure Research
- Place of Presentation
  Castellani Parkhotel, Sarzburg, Austria
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] Loss of ELOVL1 enzyme depletes very long-chain fatty acids and causes lethal skin barrier disruption in mice.2013
- Author(s)
  Suzuki S, Nomura T, Sassa T, Ohno Y, Akiyama M, Kihara A and Shimizu H.
- Organizer
  International Investigative Dermatology
- Place of Presentation
  The Edinburgh International Conference Centre, Edinburgh, UK
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] Functional characterization of very long-chain sphingolipids produced by ELOVL12012
- Author(s)
  Sassa, T
- Organizer
  Gordon Research Conference (Glycolipid & Sphingolipid Biology)
- Place of Presentation
  Renaissance Tuscany Il Ciocco Resort（イタリア）
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] Functional characterization of very long-chain sphingolipids produced by ELOVL12012
- Author(s)
  Takayuki Sassa and Akio Kihara
- Organizer
  Gordon Research Conference, Glycolipid and Sphingolipid Biology
- Place of Presentation
  Renaissance Tuscany Il Ciocco Resort (Italy)
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] C24スフィンゴ脂質とC16スフィンゴ脂質はHeLa細胞におけるアポトーシスへ異なる影響を及ぼす2012
- Author(s)
  佐々貴之
- Organizer
  日本薬学会第132年会
- Place of Presentation
  北海道大学(札幌)
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] C24スフィンゴ脂質のアポトーシスにおける役割2011
- Author(s)
  佐々貴之
- Organizer
  第4回セラミド研究会学術集会
- Place of Presentation
  北海道大学(札幌)
- Year and Date
  2011-10-28
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] シスプラチン誘導性アポトーシスにおけるセラミドの脂肪酸鎖長の役割2011
- Author(s)
  佐々貴之
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都国際会議場(京都)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23370057
[Presentation] 常染色体劣性遺伝精神遅滞に見られるTER P182L変異体の生化学的解析.
- Author(s)
  安部健介, 大野祐介, 佐々貴之, 木原章雄.
- Organizer
  第55回日本脂質生化学会
- Place of Presentation
  松島大観荘，仙台
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] 極長鎖脂肪酸伸長酵素Elovl1は表皮において層特異的な制御を受け皮膚バリアに必須の役割を果たす.
- Author(s)
  佐々貴之, 大野祐介, 鈴木翔多朗, 乃村俊史, 秋山真志, 田口良, 清水宏, 糸原重美, 木原章雄.
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜，横浜
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] Fatty acid elongase Elovl1 is essential for the synthesis of ≥C26 ceramides and epidermal permeability barrier formation.
- Author(s)
  Sassa T, Ohno Y, Suzuki S, Nomura T, Akiyama M, Taguchi R, Shimizu H, Itohara S and Kihara A.
- Organizer
  Gordon Research Conference (Glycolipid & Sphingolipid Biology)
- Place of Presentation
  Four Points Sheraton, Ventura, USA
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] ELOVL1の欠損は致死的な皮膚バリア障害を引き起こす.
- Author(s)
  鈴木翔多朗, 乃村俊史, 佐々貴之, 大野祐介, 中村秀樹, 秋山真志, 木原章雄, 清水宏.
- Organizer
  第40回皮膚かたち研究学会学術大会
- Place of Presentation
  石垣記念ホール，東京
- Data Source
  KAKENHI-PROJECT-24590073
[Presentation] 家族性精神遅滞に見られるTER P182L変異体の生化学的解析.
- Author(s)
  安部健介, 大野祐介, 佐々貴之, 木原章雄.
- Organizer
  日本薬学会北海道支部140回例会
- Place of Presentation
  札幌コンベンションセンター，札幌
- Data Source
  KAKENHI-PROJECT-24590073

1. KIHARA Akio (50333620)

# of Collaborated Projects: 3 results

# of Collaborated Products: 42 results
2. OBARA Keisuke (30419858)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. OHNO Yusuke (50611498)

# of Collaborated Projects: 2 results

# of Collaborated Products: 15 results
4. HATTORI Satoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 要匡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 秋山真志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sassa Takayuki 佐々 貴之

SASSA Takayuki 佐々 貴之

佐々 貴之 サッサ タカユキ

Research Projects

Research Products

Co-Researchers

Diversity and function of very-long-chain lipids in the formation of permeability barrierPrincipal Investigator

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Distribution and function of very-long-chain lipids in the formation digestive duct barrier.Principal Investigator

Principal Investigator

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Review Section

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Study of very long-chain fatty acids using genetically modified mice.Principal Investigator

Principal Investigator

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Production and metabolism of very long-chain fatty acids and pathology due to their abnormal metabolism

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Fatty acid elongase ELOVL1: function and diseasesPrincipal Investigator

Principal Investigator

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Elucidation of the synthetic mechanism, disorders, and physiological functions of very long-chain fatty acids

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Elucidation of the mechanism of intracellular phosphatidylinositol trafficking by the Phs1 family

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ゼブラフィッシュ小脳プルキンエ細胞活動観察系の確立Principal Investigator

Principal Investigator

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Research Institution

[Journal Article] Relationship between time-dependent epidermal ceramide composition changes and skin barrier function in adult mice2025

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[Journal Article] Comparison of skin barrier abnormalities and epidermal ceramide profiles among three ω-O-acylceramide synthesis-deficient mouse strains2024

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[Journal Article] Importance of ceramides containing very-long-chain fatty acids in oral barrier function2024

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[Journal Article] Involvement of ω-O-acylceramides and protein-bound ceramides in oral permeability barrier formation2023

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[Journal Article] Incomplete elongation of ultra-long-chain polyunsaturated acyl-CoAs by the fatty acid elongase ELOVL4 in spinocerebellar ataxia type 342023

Author(s)

Journal Title

Sassa Takayuki 佐々貴之

SASSA Takayuki 佐々貴之

佐々貴之サッサタカユキ