Kimura Ryoichi 木村良一

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KIMURA Ryoichi 木村良一

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Researcher Number	20343022
Other IDs
Affiliation (Current)	2025: 山陽小野田市立山口東京理科大学, 共通教育センター, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 山陽小野田市立山口東京理科大学, 共通教育センター, 准教授 2004 – 2005: 弘前大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related / General physiology Except Principal Investigator Basic Section 48020:Physiology-related / Basic Section 59040:Nutrition science and health science-related / Basic Section 42030:Animal life science-related / General physiology
Keywords	Principal Investigator 5XFAD / 遺伝子改変マウス / 糖尿病 / アミロイドベータ / アミリン / アルツハイマー病 / 認知機能 / ニコチン / methyllycaconitine / 海馬 … More / γオッシレーション / α7-ACh受容体 / ミトコンドリア膜電位 / ATP-感受性K+チャネル / ロテノン / イプタカリム / ドパミン性ニューロン / 黒質 … More Except Principal Investigator シナプス可塑性 / PCR / 電位依存性Naチャネル / GABAA受容体 / 海馬学習 / Amyloid β1-42 / Learning and memory / membrane resistance / Lecanemab / AMPA receptor / GABAA receptor / synaptic plasticity / Intrinsic plasticity / Amyloid beta / ライブイメージング / 機能性表示食品素材 / リアノジン受容体 / 筋萎縮 / カルシウム / 骨格筋 / 画像解析 / 記憶・学習 / 加齢 / イメージング / Caホメオスタシス / 海馬 / 老化 / Phospholipase C / Insulin secretion / Hepatocyte / Receptor antibody / α_1-adrenoceptor / Islet b-cells / 電位依存性K^+チャネル / L-型Ca^<2+>チャネル / 百日咳毒素 / α_2-アドレナリン受容体 / フォスフォリパーゼC / インスリン分泌 / 肝細胞 / 受容体抗体 / α_1-アドレナリン受容体 / 膵ラ島β細胞 Less

Extracting the detrimental effects of amyloid beta oligomer using contextual learning and controlling it with antagonist molecules
- Principal Investigator
  
  美津島大
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Yamaguchi University
加齢性認知機能低下に伴う細胞内Caホメオスタシスの変化の可視化
- Principal Investigator
  
  伊藤公一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42030:Animal life science-related
- Research Institution
  The University of Tokyo
骨格筋機能維持・改善にむけた分子栄養学的基盤研究
- Principal Investigator
  
  山澤徳志子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Jikei University School of Medicine
Brain amylin receptor signaling as novel therapeutic targets for alzheimer's disease.Principal Investigator
- Principal Investigator
  
  KIMURA Ryoichi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Tokyo University of Science, Yamaguchi
nACh受容体/Na^+チャネルの遺伝子異常に起因するてんかんの発症調節物質の特定Principal Investigator
- Principal Investigator
  
  木村良一
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Hirosaki University
Genetic analysis of excitatory α_1-adrenergic receptor in insulin secreting islet β-cells of the rat
- Principal Investigator
  
  SUGA Sechiko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Hirosaki University

All 2024 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Extracellular vesicles enriched with amylin receptor are cytoprotective against the A? toxicity in vitro2022
- Author(s)
  Soudy Rania、Kimura Ryoichi、Fu Wen、Patel Aarti、Jhamandas Jack
- Journal Title
  
  PLOS ONE
  
  Volume: 17 Issue: 4 Pages: e0267164-e0267164
- DOI
  10.1371/journal.pone.0267164
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07014
[Journal Article] アルツハイマー病における脳内アミリン研究2022
- Author(s)
  木村　良一
- Journal Title
  
  BIO Clinica
  
  Volume: 37(11) Pages: 68-70
- Data Source
  KAKENHI-PROJECT-19K07014
[Journal Article] Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer’s Disease Mouse Models2021
- Author(s)
  Patel Aarti、Kimura Ryoichi、Fu Wen、Soudy Rania、MacTavish David、Westaway David、Yang Jing、Davey Rachel A.、Zajac Jeffrey D.、Jhamandas Jack H.
- Journal Title
  
  Molecular Neurobiology
  
  Volume: 58 Issue: 10 Pages: 5369-5382
- DOI
  10.1007/s12035-021-02490-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07014
[Journal Article] アルツハイマー病新薬としての脳内アミリン受容体阻害剤開発2020
- Author(s)
  木村　良一
- Journal Title
  
  月刊メディカル・サイエンス・ダイジェスト (MSD)
  
  Volume: 46 Pages: 896-897
- Data Source
  KAKENHI-PROJECT-19K07014
[Journal Article] Short amylin receptor antagonist peptides improve memory deficits in Alzheimer’s disease mouse model.2019
- Author(s)
  Rania Soudy, Ryoichi Kimura, Aarti Patel, Wen Fu, Kamaljit Kaur, David Westaway, Jing Yang, Jack Jhamandas
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 10942-10952
- DOI
  10.1038/s41598-019-47255-9
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07014
[Presentation] Adverse effects of Aβ1-42 oligomers: impaired contextual memory and altered intrinsic properties of CA1 pyramidal neurons2024
- Author(s)
  Min-Kaung-Wint-Mon, Kida H, Kanehisa I, Kurose M, Sakimoto Y, Ishikawa J, Kimura R, Mitsushima D.
- Organizer
  日本生理学会　第101回北九州大会
- Data Source
  KAKENHI-PROJECT-23K06348
[Presentation] Acute exposure by an intracisternal injection to the Amylin receptor antagonist AC253 improved cognitivedeficits in Alzheimer’s disease mouse models2022
- Author(s)
  Kimura, R., Zayasu, M., Ueda, T., Saiki, M., Koike, R., Ito, K., Inoue, A.
- Organizer
  FENS Forum 2022, Federation of European Neuroscience Societies, Paris, July 9-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07014
[Presentation] 創薬に繋げる病態モデルマウスの認知機能計測2021
- Author(s)
  木村良一
- Organizer
  統計数理研究所共同研究集会＜健康・医療情報学，生体計測・生体信号解析とその周辺2＞
- Invited
- Data Source
  KAKENHI-PROJECT-19K07014
[Presentation] アルバータ大学との革新的創薬研究2021
- Author(s)
  木村良一
- Organizer
  第8回生命科学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07014
[Presentation] 【特別講演】国際共同研究報告ー認知症克服に向けた革新的創薬アプローチ2020
- Author(s)
  木村　良一
- Organizer
  統計数理研究所共同研究集会「健康・医療情報学，生体計測・生体信号解析とその周辺」
- Invited
- Data Source
  KAKENHI-PROJECT-19K07014
[Presentation] 創薬に繋げる病態モデルマウスの認知機能計測2020
- Author(s)
  木村　良一
- Organizer
  統計数理研究所共同研究集会「健康・医療情報学，生体計測・生体信号解析とその周辺」
- Data Source
  KAKENHI-PROJECT-19K07014
[Presentation] 認知機能を計る行動実験とその応用2019
- Author(s)
  木村　良一
- Organizer
  第7回生命科学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07014

1. 伊藤公一 (50330874)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. 山澤徳志子 (00282616)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. SUGA Sechiko (80003408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. WAKUI Makoto (80108505)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ITOI Keiichi (60232427)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 井上明男 (80107060)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 山中大介 (10553266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 福田紀男 (30301534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 小比類巻生 (40548905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 美津島大 (70264603)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Kimura Ryoichi 木村 良一

KIMURA Ryoichi 木村 良一

Research Projects

Research Products

Co-Researchers

Extracting the detrimental effects of amyloid beta oligomer using contextual learning and controlling it with antagonist molecules

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

加齢性認知機能低下に伴う細胞内Caホメオスタシスの変化の可視化

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

骨格筋機能維持・改善にむけた分子栄養学的基盤研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Brain amylin receptor signaling as novel therapeutic targets for alzheimer's disease.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

nACh受容体/Na^+チャネルの遺伝子異常に起因するてんかんの発症調節物質の特定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic analysis of excitatory α_1-adrenergic receptor in insulin secreting islet β-cells of the rat

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Extracellular vesicles enriched with amylin receptor are cytoprotective against the A? toxicity in vitro2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] アルツハイマー病における脳内アミリン研究2022

Author(s)

Journal Title

Data Source

[Journal Article] Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer’s Disease Mouse Models2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] アルツハイマー病新薬としての脳内アミリン受容体阻害剤開発2020

Author(s)

Journal Title

Data Source

[Journal Article] Short amylin receptor antagonist peptides improve memory deficits in Alzheimer’s disease mouse model.2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Adverse effects of Aβ1-42 oligomers: impaired contextual memory and altered intrinsic properties of CA1 pyramidal neurons2024

Author(s)

Organizer

Data Source

[Presentation] Acute exposure by an intracisternal injection to the Amylin receptor antagonist AC253 improved cognitivedeficits in Alzheimer’s disease mouse models2022

Author(s)

Organizer

Data Source

[Presentation] 創薬に繋げる病態モデルマウスの認知機能計測2021

Author(s)

Organizer

Data Source

[Presentation] アルバータ大学との革新的創薬研究2021

Author(s)

Organizer

Data Source

Kimura Ryoichi 木村良一

KIMURA Ryoichi 木村良一