OKUNO Hiroaki 奥野洋明

Researcher Number	20356710
Other IDs
Affiliation (based on the past Project Information) *help	2005 – 2007: 東邦大学, 薬学部, 教授
Review Section/Research Field	Principal Investigator Living organism molecular science
Keywords	Principal Investigator Alzet / transgenic mouse / in vivo activity / quartz-crystal microbalance / in vitro activity / aggregation inhibitor / amyloid β pentide / 水晶発振子マイクロバランス / 培養細胞 / 水晶発振子ミクロ天秤 … More / 凝集乖離能 / 分子認識 / 会合阻害剤 / アミロイドベータ蛋白 Less

Development of aggregation disrupters for amyloid proteinsPrincipal Investigator
- Principal Investigator
  
  OKUNO Hiroaki
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Living organism molecular science
- Research Institution
  Toho University

All 2008 2007 2006 2005

All Journal Article Presentation Patent

[Journal Article] Development of aggregation inhibitors for amyloid-β peptides and their evaluation by quartz-crystal microbalance2007
- Author(s)
  Okuno, Mori, Okada, Yokoyama, Suzuki
- Journal Title
  
  Chemical Biology&Drug Design 69
  
  Pages: 356-361
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] Synthesis and evaluation of a novel lipid-peptide conjugate for functionalized liposome2007
- Author(s)
  Nobuhiro Yagi, Yuko Yano, Kentaro Hatanaka, Yuusku Yokoyama, Hiroaki Okuno
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry Letters 17
  
  Pages: 2590-2593
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] Development of aggregation inhibitors for amyloid-β peptides and their evaluation by quartz-crystal microbalance2007
- Author(s)
  Okuno, Mori, Okada, Yokoyama and Suzuki
- Journal Title
  
  Chemical Biology & Drug Design 69
  
  Pages: 356-361
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] Synthesis and evaluation of a novel lipid-peptide conjugate for functi onalized linosome2007
- Author(s)
  Yagi, Yano, Hatanaka, Yokoyama, Hiroaki Okuno
- Journal Title
  
  Bioorganic&Medicinal Chemistry Letters 17
  
  Pages: 2590-2593
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] Synthesis of amyloid aggregation inhibitors&its evaluation by QCM2007
- Author(s)
  Okuno, Mori, Okada
- Journal Title
  
  Alzheimer's Disease:New Advances
  
  Pages: 451-454
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] Development of aggregation inhibitors for amyloid-β peptides and their evaluation by quartz-crystal microbalance2007
- Author(s)
  Hiroaki, Okuno, Kanae, Mori, Tomoko, Okada, Yuusaku, Yokoyama, Hideharu, Suzuki
- Journal Title
  
  Chemical Biology & Drug Design 69(5)
  
  Pages: 356-361
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] Synthesis of amyloid aggregation inhibitors & its evaluation by QCM2007
- Author(s)
  Okuno, Mori and Okada
- Journal Title
  
  Alzheimer's Disease: New Advances
  
  Pages: 451-454
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] Chemoselective Palladium Catalyzed Reaction in Aqueous Media : Selectivity in the Reaction of Haloanilines with 1, 1-Dimethylallyl Alcohol2007
- Author(s)
  Yokoyama, Takagi, Kaneko, Tsubaki, H Okuno
- Journal Title
  
  Advanced Synthesis ＆ Catalysis 349
  
  Pages: 662-668
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] Synthesis of amyloid aggregation inhibitors and its evaluation by QCM2007
- Author(s)
  H., Okuno, K., Mori, T., Okada
- Journal Title
  
  Alzheimer's Disease : New Advances, Collection of Selected Articles of Papers Presented at the 10th International Conference on Alzheimer 's Disease and Related Disorders (Madrid, Spain,Editors : Khalid Iqbal Bengt Winbiad, Jesus Avila, by MEDIMOND S.r.I.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] Development of aggregation inhibitors for amyloid-β peptides and their evaluation by quartz-crystal microbalance2007
- Author(s)
  Hiroaki Okuno, Kanae Mori, Tomoko Okada, Y. Yokoyama, H. Suzuki
- Journal Title
  
  Chemical Biology ＆ Drug Design (submitted)
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] Synthesis and evaluation of a novel lipid-peptide conjugate for functionalized liposome2007
- Author(s)
  Nobuhiro, Yagi, Yuko, Yano, Kentaro, Hatanaka, Yuusaku, Yokoyama, Hiroaki, Okuno
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 17(9)
  
  Pages: 2590-2593
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] Synthesis and evaluation of a novel lipid-peptide conjugate for functi onalized liposome2007
- Author(s)
  Yagi, Yano, Hatanaka, Yokoyama and Hiroaki Okuno
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 17
  
  Pages: 2590-2593
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] Synthesis of amyloid aggregation inhibitors and its evaluation by QCM2006
- Author(s)
  H.Okuno, K.Mori, T.Okada
- Journal Title
  
  Proceedings of the 10th International Conference on Alzheimer's Disease and Related Disorders(July 16-20, 2006, Madrid, Spain) (未着)
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] An improved synthesis of optically pure (R)-4-bromo-N-Methyl-1-tosyltryptophan derivative, akey intermediate in the synthesis of ergot alkaloids2006
- Author(s)
  Yokoyama Y, Yamaguchi T, Sato M, Kobayashi E, Murakami Y, Okuno H
- Journal Title
  
  Chem. Pharm. Bull. 54
  
  Pages: 1715-1719
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] Convenient Method for Monitoring Aβ Aggregation bi Quartz-Crystal Microbalance2006
- Author(s)
  hiroaki Okuno, Kanae Mori, Tomofumi jitsukawa, Hiromi Inoue, S. Chiba
- Journal Title
  
  Chemical Biology ＆ Drug Design 68
  
  Pages: 273-275
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] Further structural analysis of GnRH complexes with metal ions2005
- Author(s)
  Nakamura, Kodaka, El-Mehasseb, Gajewska, Okuno, Ochwanowska, Witek, Kozlowski, Kochman
- Journal Title
  
  Neuroendocrinology Letters 26
  
  Pages: 247-252
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] A Total Synthesis of 1-Methoxycanthin-6-one : An Efficient One-Pot Synthesis of the Canthin-6-one Skeleton from b-Carboline-1-carboxyaldehyde2005
- Author(s)
  Suzuki H, Adachi M, Ebihara Y, Gyoutoku H, Furuya H, Murakami Y, Okuno H
- Journal Title
  
  Synthesis
  
  Pages: 28-32
- Data Source
  KAKENHI-PROJECT-17310132
[Journal Article] An improved synthesis of optically pure (R)-4-bromo-N-methyl-1-tosyltryptophan derivative, a key intermediate in the synthesis of ergot alkaloids2005
- Author(s)
  Yokoyama Y, Hara R, Kato N, Murakami Y, Okuno H
- Journal Title
  
  Heterocycles 65
  
  Pages: 1455-1459
- Data Source
  KAKENHI-PROJECT-17310132
[Patent] アミロイドベータ凝集阻害作用を有するフェノール誘導体2008
- Inventor(s)
  奥野、鈴木、石神
- Industrial Property Rights Holder
  奥野、鈴木、石神、興和(株)
- Industrial Property Number
  2008-041928
- Filing Date
  2008-02-22
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17310132
[Patent] トリプトファン誘導体、その製造方法及びそれを有効成分とするインドールアミン酸素添加酵素阻害剤2007
- Inventor(s)
  滝川修, 秋元秀俊, 奥野洋明, 横山祐作
- Industrial Property Rights Holder
  財団法人ヒューマンサイエンス振興財団
- Industrial Property Number
  2007-041962
- Filing Date
  2007-02-22
- Data Source
  KAKENHI-PROJECT-17310132
[Patent] アミロイドベータ凝集阻害作用を有するフェノール誘導体2007
- Inventor(s)
  奥野洋明, 鈴木英治, 石神昭人
- Industrial Property Rights Holder
  奥野洋明, 鈴木英治, 石神昭人, 興和創薬
- Industrial Property Number
  2007-044155
- Filing Date
  2007-02-23
- Data Source
  KAKENHI-PROJECT-17310132
[Presentation] Synthesis and Evaluation of Aggregation Inhibitors for Amyloid-β Proteins2007
- Author(s)
  Hiroaki Okuno(招待講演)
- Organizer
  16th Camerino-Noordwijkerhout Symposium
- Place of Presentation
  University of Camerino,Italy
- Year and Date
  2007-09-12
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17310132
[Presentation] Synthesis and Evaluation of Aggregation Inhibitors for Amyloid-β Proteins2007
- Author(s)
  Hiroaki, Okuno (invited lecture)
- Organizer
  16th Camerino-Noordwijkerhout Symposium
- Place of Presentation
  University of Camerino, Italy
- Year and Date
  2007-09-09
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17310132

1. SUZUKI Hideharu (40187753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

OKUNO Hiroaki 奥野 洋明

Research Projects

Research Products

Co-Researchers

Development of aggregation disrupters for amyloid proteinsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Development of aggregation inhibitors for amyloid-β peptides and their evaluation by quartz-crystal microbalance2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Synthesis and evaluation of a novel lipid-peptide conjugate for functionalized liposome2007

Author(s)

Journal Title

Data Source

[Journal Article] Development of aggregation inhibitors for amyloid-β peptides and their evaluation by quartz-crystal microbalance2007

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis and evaluation of a novel lipid-peptide conjugate for functi onalized linosome2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Synthesis of amyloid aggregation inhibitors&its evaluation by QCM2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Development of aggregation inhibitors for amyloid-β peptides and their evaluation by quartz-crystal microbalance2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Synthesis of amyloid aggregation inhibitors & its evaluation by QCM2007

Author(s)

Journal Title

Data Source

[Journal Article] Chemoselective Palladium Catalyzed Reaction in Aqueous Media : Selectivity in the Reaction of Haloanilines with 1, 1-Dimethylallyl Alcohol2007

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of amyloid aggregation inhibitors and its evaluation by QCM2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Development of aggregation inhibitors for amyloid-β peptides and their evaluation by quartz-crystal microbalance2007

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis and evaluation of a novel lipid-peptide conjugate for functionalized liposome2007

Author(s)

Journal Title

Description

Data Source

[Journal Article] Synthesis and evaluation of a novel lipid-peptide conjugate for functi onalized liposome2007

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of amyloid aggregation inhibitors and its evaluation by QCM2006

Author(s)

Journal Title

Data Source

[Journal Article] An improved synthesis of optically pure (R)-4-bromo-N-Methyl-1-tosyltryptophan derivative, akey intermediate in the synthesis of ergot alkaloids2006

Author(s)

Journal Title

Data Source

[Journal Article] Convenient Method for Monitoring Aβ Aggregation bi Quartz-Crystal Microbalance2006

Author(s)

Journal Title

Data Source

[Journal Article] Further structural analysis of GnRH complexes with metal ions2005

Author(s)

Journal Title

Data Source

OKUNO Hiroaki 奥野洋明