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Nishiwaki Yuuko  西脇 優子

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Nishiwaki Yuko  西脇 優子

NISHIWAKI Yuko  西脇 優子

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Researcher Number 20360620
Other IDs
Affiliation (Current) 2025: 沖縄科学技術大学院大学, 神経発生ユニット, シニアスタッフサイエンティスト
Affiliation (based on the past Project Information) *help 2021 – 2024: 沖縄科学技術大学院大学, 神経発生ユニット, グループリーダー
2015 – 2016: 沖縄科学技術大学院大学, 神経発生ユニット, 研究員
2014: 沖縄科学技術大学院大学, Developmental Neurobiology Unit, 研究員
2012: 沖縄科学技術大学院, 神経発生ユニット, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 56060:Ophthalmology-related / Developmental biology
Except Principal Investigator
Neuroscience in general
Keywords
Principal Investigator
細胞死 / 視細胞変性 / 小胞輸送 / BNip1 / 神経変性 / 視細胞 / チトクロムC / 細胞内カルシウム / Drp1 / ミトコンドリア / 細胞死誘導 … More
Except Principal Investigator
… More BH3蛋白質 / BNip1 / β-SNAP / 細胞死 / BH3-only蛋白質 / ゼブラフィッシュ / 小胞輸送 / アポトーシス / 遺伝疾患 / 視細胞変性 / 脳神経疾患 / 神経科学 Less
  • Research Projects

    (4 results)
  • Research Products

    (41 results)
  • Co-Researchers

    (3 People)
  •  光情報伝達の主要蛋白である錐体型PDE6変異による視細胞変性の分子機構の解明Principal Investigator

    • Principal Investigator
      西脇 優子
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      Okinawa Institute of Science and Technology Graduate University
  •  Analysis of Drp1 mediated apoptosis through formation of ER-mitochondria contact sitePrincipal Investigator

    • Principal Investigator
      Nishiwaki Yuko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56060:Ophthalmology-related
    • Research Institution
      Okinawa Institute of Science and Technology Graduate University
  •  ER-resident BH3-only protein, BNip1, induces apoptosis in response to excessive activation of vesicular transport in zebrafish photoreceptorsPrincipal Investigator

    • Principal Investigator
      Nishiwaki Yuko
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Developmental biology
    • Research Institution
      Okinawa Institute of Science and Technology Graduate University
  •  Mechanism underlying photoreceptor degeneration in response to vesicular fusion defects

    • Principal Investigator
      MASAI Ichiro
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neuroscience in general
    • Research Institution
      沖縄科学技術大学院大学

All 2022 2021 2016 2015 2013 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] The BH3-only SNARE BNip1 mediates photoreceptor apoptosis in response to vesicular fusion defects2013

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Journal Title

      Developmental Cell

      Volume: 25 Issue: 4 Pages: 374-387

    • DOI

      10.1016/j.devcel.2013.04.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23650173, KAKENHI-PROJECT-24570245
  • [Journal Article] (*equal contribution; #corresponding authors) Ectopic expression of the cone-specific Gprotein-coupled receptor kinase GRK7 in zebrafish rods leads to decreased photosensitivity and compromised visual performance2011

    • Author(s)
      Vogalis,F., Shiraki,T., Kojima,D., Fukada,Y. & Lamb,T.
    • Journal Title

      J. Physiol. (London)

      Volume: 589 Issue: 9 Pages: 2321-2348

    • DOI

      10.1113/jphysiol.2010.204156

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19107002, KAKENHI-PROJECT-21570073, KAKENHI-PROJECT-23227002, KAKENHI-PROJECT-23650173
  • [Presentation] Drp1は小胞輸送の破綻による光受容細胞のアポトーシスに必要である2022

    • Author(s)
      西脇 優子
    • Organizer
      日本発生生物学会 第55回大会
    • Data Source
      KAKENHI-PROJECT-21K09735
  • [Presentation] Drp1 is required for photoreceptor apoptosis in response to vesicular fusion defects2022

    • Author(s)
      西脇 優子
    • Organizer
      第28回 小型魚類研究会
    • Data Source
      KAKENHI-PROJECT-21K09735
  • [Presentation] 小胞輸送の破綻により引き起こされる視細胞変性におけるDrp1の役割2021

    • Author(s)
      西脇 優子
    • Organizer
      第73回日本細胞生物学会大会
    • Data Source
      KAKENHI-PROJECT-21K09735
  • [Presentation] ER-resident BH3-only protein, BNip1, induces apoptosis in response to excessive activation of vesicular transport in zebrafish photoreceptors2016

    • Author(s)
      Yuko Nishiwaki, Miyuki Suenaga, Masato Araragi, and Ichiro Masai
    • Organizer
      XVIIth International Symposium on Retinal Degenerations
    • Place of Presentation
      Kyoto
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26440128
  • [Presentation] An ER-resident BH3-only protein, BNip1, induces apoptosis in response to excessive vesicular transport during photoreceptor differentiation2016

    • Author(s)
      Yuko Nishiwaki, Miyuki Suenaga, Masato Araragi, and Ichiro Masai
    • Organizer
      The ISER XXII Biennial Meeting
    • Place of Presentation
      東京
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26440128
  • [Presentation] Mechanism that links vesicular fusion defects and apoptosis in photoreceptors2016

    • Author(s)
      Yuko Nishiwaki, Miyuki Suenaga, Masato Araragi, and Ichiro Masai
    • Organizer
      The 39th Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      横浜
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26440128
  • [Presentation] Mechanism that links vesicular fusion defects and apoptosis in photoreceptors2016

    • Author(s)
      Yuko Nishiwaki, Miyuki Suenaga, Masato Araragi, and Ichiro Masai
    • Organizer
      JSDB Special Symposium: Frontier of Developmental Biology Hosted by JSDB
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-26440128
  • [Presentation] Mechanism that links vesicular fusion defects and apoptosis in photoreceptors2016

    • Author(s)
      Yuko Nishiwaki, Miyuki Suenaga, Masato Araragi, and Ichiro Masai
    • Organizer
      the Allied Genetics 2016 Conference
    • Place of Presentation
      Orland, USA
    • Year and Date
      2016-07-14
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26440128
  • [Presentation] 小胞輸送障害が引き起こす視細胞変性の機構2016

    • Author(s)
      Yuko Nishiwaki, Miyuki Suenaga, Masato Araragi, and Ichiro Masai
    • Organizer
      The 39th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-26440128
  • [Presentation] Mechanism that links vesicular fusion defects and apoptosis in photoreceptors2015

    • Author(s)
      Yuko Nishiwaki
    • Organizer
      Academia Sinica-OIST Joint Meeting
    • Place of Presentation
      Taiwan, Taipei
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26440128
  • [Presentation] Analysis of three photoreceptor mutants2015

    • Author(s)
      Nishiwaki, Y.
    • Organizer
      岡本先生時實賞受賞記念シンポジウム
    • Place of Presentation
      東京都
    • Year and Date
      2015-01-10
    • Data Source
      KAKENHI-PROJECT-26440128
  • [Presentation] Over expression of ER-localized Bcl2 suppresses BNip1-dependent apoptosis.2015

    • Author(s)
      Yuko Nishiwaki
    • Organizer
      第48回日本発生生物学会年会
    • Place of Presentation
      つくば
    • Year and Date
      2015-06-03
    • Data Source
      KAKENHI-PROJECT-26440128
  • [Presentation] Molecular Mechanism That Converts Vesicular Fusion Defects Into Apoptosis In Photoreceptors2015

    • Author(s)
      Yuko Nishiwaki
    • Organizer
      The 9th European Zebrafish Meeting
    • Place of Presentation
      Oslo, Norway
    • Year and Date
      2015-06-30
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26440128
  • [Presentation] Characterization of a zebrafish mutant showing cone photoreceptor degeneration2013

    • Author(s)
      Iribarne, M., Nishiwaki, Y., and Masai, I.
    • Organizer
      The 46th Annual Meeting of the Japanese Society of Developmental Biologists
    • Place of Presentation
      Matsue, Japan
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] Characterization of a zebrafish mutantshowing cone photoreceptor degeneration2013

    • Author(s)
      Iribarne, M., Nishiwaki, Y., and Masai, I.
    • Organizer
      The 46th Annual Meeting of the Japanese Society of Developmental Biologists Matsue,
    • Place of Presentation
      Shimane, Japan
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] Syntaxin18 cis-SNARE complex is a novel alarm factor that detects vesicular transport defects2013

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      The 46th Annual Meeting of the Japanese Society of Developmental Biologists
    • Place of Presentation
      Matsue, Japan
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] Syntaxin18cis-SNARE complex is a novel alarm factorthat detects vesicular transport defects2013

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      The 46th Annual Meeting of the Japanese Society of Developmental Biologists.
    • Place of Presentation
      Matsue, Shimane Japan
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] The BH3-only SNARE of syntaxin18, BNip1, is a mediator of photoreceptor apoptosis in response to vesicular fusion defects2012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      The 35th annual meeting of the Japan Neuroscience Society
    • Place of Presentation
      Nagoya, Japan
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] The BH3-onlySNARE of syntaxin18, BNip1, is a mediatorof photoreceptor apoptosis in response tovesicular fusion defects2012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      The 35th annual meeting of the Molecular Biology Society
    • Place of Presentation
      Japan. Fukuoka
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE, BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      10th International Conference Zebrafish Development and Genetics
    • Place of Presentation
      Madison, USA
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] The BH3-only SNARE of syntaxin18, BNip1, is a mediator of photoreceptor apoptosis in response to vesicular fusion defects2012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      The 35th annual meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Fukuoka, Japan
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE, BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      Joint meeting of the 45th annual meeting of the Japanese society of Developmental Biologists & the 64th annual meeting of the Japanese society of Cell Biology
    • Place of Presentation
      Kobe, Japan
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] Geneticmutation of beta-SNAP causesphotoreceptor degeneration through theactivation of the BH3-only SNARE, BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      Joint meeting of the 45th annual meeting of the Japanese society of DevelopmentalBiologists & the 64thannual meeting of theJapanese society of Cell Biology.
    • Place of Presentation
      Kobe,Japan
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE, BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      APDBC Taiwan 2012 Asia-Pacific Developmental Biology Conference 2012
    • Place of Presentation
      Taipei, Taiwan
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] The BH3-onlySNARE of syntaxin18, BNip1, is a mediatorof photoreceptor apoptosis in response tovesicular fusion defects2012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      Neuroscience 2012.The 35thannual meeting of the JapanNeuroscience Society.
    • Place of Presentation
      Nagoya, Japan
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE, BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      The 18th Japanese Medaka and zebrafish meeting
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE,BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      The 18th Japanese Medaka and zebrafish meeting.
    • Place of Presentation
      Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] Genetic mutation of beta-SNAP causes photoreceptor degeneration through the activation of the BH3-only SNARE, BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      APDBC Taiwan 2012 Asia-Pacific Developmental Biology Conference 2012
    • Place of Presentation
      Taipei Innovation City Convention Center, Taipei, Taiwan
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] The BH3-only SNARE of syntaxin18, BNip1, mediates photoreceptor apoptosis in response to vesicular fusion defects2012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      Gordon researchconference ? visual system development.
    • Place of Presentation
      Colby-Sawyer College, New London, NH
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] Geneticmutation of beta-SNAP causes photoreceptordegeneration through the activation of theBH3-only SNARE, BNip12012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y.,Oguri, E., Nakamura, S., Suzuki, S.,Yuasa-Kawada, J., Kinoshita-Kawada, M.,Mochizuki, T., and Masai, I.
    • Organizer
      10th International Conference Zebrafish Development and Genetics
    • Place of Presentation
      Madison, USA
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] The BH3-only SNARE of syntaxin18, BNip1, mediates photoreceptor apoptosis in response to vesicular fusion defects2012

    • Author(s)
      Nishiwaki, Y., Yoshizawa, A., Kojima, Y., Oguri, E., Nakamura, S., Suzuki, S., Yuasa-Kawada, J., Kinoshita-Kawada, M., Mochizuki, T., and Masai, I.
    • Organizer
      Gordon research conference visual system development
    • Place of Presentation
      New London, USA
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] Mutation of beta-SNAP induces a mitochondria-dependent apoptosis in zebrafish photoreceptors2011

    • Author(s)
      西脇優子、鈴木祥平、吉澤あすか、小島豊、望月俊昭、政井一郎
    • Organizer
      第7回 ヨーロッパ ゼブラフィッシュ国際会議
    • Place of Presentation
      エジンバラ、英国
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] A zebrafish corona mutation induces a Bcl2-dependent apoptosis in photoreceptor2011

    • Author(s)
      西脇優子、鈴木祥平、吉澤あすか、小島豊、望月俊昭、政井一郎
    • Organizer
      第44回 日本発生生物学会年会
    • Place of Presentation
      沖縄、日本
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] Azebrafish corona mutation induces aBcl2-dependent apoptosis in photoreceptor2011

    • Author(s)
      Nishiwaki, Y., Suzuki, S., Yoshizawa, A.,Kojima, Y., Mochizuki, T., Masai, I.
    • Organizer
      44th Annual Meeting of the Japanese Society of Developmental Biologists
    • Place of Presentation
      Okinawa Convention Center (Ginowan City)
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] Mutation of beta-SNAP induces amitochondria-dependent apoptosis inzebrafish photoreceptors2011

    • Author(s)
      Nishiwaki, Y., Suzuki, S., Yoshizawa, A.,Kojima, Y., Mochizuki, T., Masai, I.
    • Organizer
      7th EuropeanZebrafish Meeting
    • Place of Presentation
      Edinburgh, Scotland
    • Data Source
      KAKENHI-PROJECT-23650173
  • [Presentation] 小胞体局在型Bcl2の過剰発現はBNip1が誘導する細胞死を抑制する

    • Author(s)
      西脇優子、小栗エリ、蘭正人、中村昇平、吉澤あすか、政井一郎
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜、神奈川県
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-26440128
  • [Presentation] Molecular Mechanism that Converts Vesicular Fusion Defects into Apoptosis in Photoreceptors

    • Author(s)
      Nishiwaki Y., Nakamura S., Eri Oguri E., Araragi M., Kojima Y., Masai I.
    • Organizer
      Gordon Research Conference-Visual System Development
    • Place of Presentation
      IL Ciocco, Italy
    • Year and Date
      2014-05-25 – 2014-05-30
    • Data Source
      KAKENHI-PROJECT-26440128
  • [Presentation] Molecular Mechanism that Converts Vesicular Fusion Defects into Apoptosis in Photoreceptor

    • Author(s)
      Nishiwaki Y., Nakamura S., Eri Oguri E., Araragi M., Kojima Y., Masai I.
    • Organizer
      11th International Conference on Zebrafish Development and Genetics
    • Place of Presentation
      Madison, Wisconsin, USA,
    • Year and Date
      2014-06-24 – 2014-06-28
    • Data Source
      KAKENHI-PROJECT-26440128
  • [Presentation] Molecular Mechanism that Converts Vesicular Fusion Defects into Apoptosis in Photoreceptors

    • Author(s)
      Nishiwaki Y., Nakamura S., Eri Oguri E., Araragi M., Kojima Y., Masai I.
    • Organizer
      Gordon Research Seminar – Visual System Development
    • Place of Presentation
      IL Ciocco, Italy
    • Year and Date
      2014-05-25 – 2014-06-30
    • Data Source
      KAKENHI-PROJECT-26440128
  • 1.  MASAI Ichiro (50242087)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 33 results
  • 2.  小島 大輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 3.  深田 吉孝
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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