Koizumi Noriko 小泉範子

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KOIZUMI Noriko 小泉範子

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Researcher Number	20373087
Other IDs
Affiliation (Current)	2025: 同志社大学, 生命医科学部, 教授
Affiliation (based on the past Project Information) *help	2014 – 2023: 同志社大学, 生命医科学部, 教授 2012: 同志社大学, 生命医科学部, 教授 2011: Doshisha University, 教授 2010: Doshisha University, 生命医科学部, 教授 2008 – 2009: Doshisha University, 生命医科学部, 准教授 2007: Doshisha University, 研究開発推進機構, 准教授 2004 – 2006: 同志社大学, 研究開発推進機構, 助教授
Review Section/Research Field	Principal Investigator Ophthalmology / Basic Section 56060:Ophthalmology-related Except Principal Investigator Orthopaedic surgery / Ophthalmology
Keywords	Principal Investigator フックス角膜内皮ジストロフィ / 薬物治療 / 再生医療 / 角膜内皮細胞 / 炎症性サイトカイン / 眼科 / トリプレットリピート / モデルマウス / mTOR / 創薬 … More / ラパマイシン / mTORシグナル / 細胞・組織 / TGF-βシグナル / 角膜内皮障害 / 小胞体ストレス / Fuchs角膜内皮ジストロフィ / インテグリン / 細胞外マトリクス / SASP / p38MAPキナーゼ阻害剤 / ラミニン / p38 MAPキナーゼ / 細胞老化 / 組織保存 / 角膜 / 細胞移植 / アルジネート / 角膜再生医療 / 霊長類 / 細胞周期制御分子 / 薬剤耐性菌 / Stevens-Johnson症候群 / 蛋白解析 / インターロイキン8 / 重症眼表面疾患 … More Except Principal Investigator 脊椎 / 生物・生体工学 / 生体工学 / 生物 / 整形外科学 / 解剖学 / 脊椎脊髄病学 / ゼラチン / 再生医療 / 移植 / コラーゲンシート / 羊膜 / 培養 / 角膜内皮細胞 / 角膜 Less

3塩基繰り返し配列を有するマウスを用いたフックス角膜内皮ジストロフィの病態解明Principal Investigator
- Principal Investigator
  
  小泉範子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Doshisha University
Significance of mTOR signaling in the pathogenesis of Fuchs endothelial corneal dystrophyPrincipal Investigator
- Principal Investigator
  
  KOIZUMI Noriko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Doshisha University
Involvement of endoplasmic reticulum stress in the pathophysiology of Fuchs endothelial corneal dystrophyPrincipal Investigator
- Principal Investigator
  
  Koizumi Noriko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Doshisha University
Investigation of molecular mechanism of cellular-senescence of corneal endothelial cells in association with cell-culture and its application for corneal endothelial tissue engineeringPrincipal Investigator
- Principal Investigator
  
  Koizumi Noriko
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Ophthalmology
- Research Institution
  Doshisha University
選択的Rhoキナーゼ阻害剤を用いた培養角膜内皮細胞移植の開発Principal Investigator
- Principal Investigator
  
  小泉範子
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Doshisha University
Three dimensional microstructure of spinal endplate: relationship between nano-scale structure of nutrition canal and biochemical characteristics of intervertebral disc
- Principal Investigator
  
  INOUE Nozomu
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Doshisha University
Corneal Tissue Engineering Using AlginatePrincipal Investigator
- Principal Investigator
  
  KOIZUMI Noriko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Doshisha University
霊長類角膜内皮細胞の増殖制御機構の解明Principal Investigator
- Principal Investigator
  
  小泉範子
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Doshisha University
培養ヒト角膜内皮細胞シート自家移植の臨床応用を目指した開発
- Principal Investigator
  
  森和彦, 西浦正敏
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Ophthalmology
- Research Institution
  Kyoto Prefectural University of Medicine
Ocular surface疾患の予後を予測できるプロテインチップの開発Principal Investigator
- Principal Investigator
  
  小泉範子
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Doshisha University

[Book] encyclopedia of the eye.(The Ocular Surface : The surgical treatment for corneal epithelial stem cell deficiency, corneal epithelial defect, and peripheral corneal ulcer.)2011
- Author(s)
  Koizumi N, Kinoshita S
- Publisher
  Elsevier Ltd., Oxfordshire(in press)
- Data Source
  KAKENHI-PROJECT-20592083
[Journal Article] Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy2018
- Author(s)
  Okumura N, Hayashi R, Koizumi N
- Journal Title
  
  Open Ophthalmol J
  
  Volume: 12 Issue: 1 Pages: 154-163
- DOI
  10.2174/1874364101812010154
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09464, KAKENHI-PROJECT-16K11307
[Journal Article] Activation of TGF-β signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy2017
- Author(s)
  Okumura N, Hashimoto K, Kitahara M, Okuda H, Ueda E, Watanabe K, Nakahara M, Sato T, Kinoshita S, Tourtas T, Schlötzer-Schrehardt U, Kruse FE, Koizumi N
- Journal Title
  
  Sci Rep
  
  Volume: 7（1） Issue: 1 Pages: 6801-6801
- DOI
  10.1038/s41598-017-06924-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10885, KAKENHI-PROJECT-16K11307
[Journal Article] Sustained activation of the unfolded protein response induces cell death in Fuchs endothelial corneal dystrophy2017
- Author(s)
  Okumura N, Kitahara M, Okuda H, Hashimoto K, Ueda E, Nakahara N, Kinoshita S, Young RD, Quantock AJ, Tourtas T, Schlötzer-Schrehardt U, Kruse FE, Koizumi N
- Journal Title
  
  Invest Ophthalmol
  
  Volume: 58（9） Issue: 9 Pages: 3697-3707
- DOI
  10.1167/iovs.16-21023
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10885, KAKENHI-PROJECT-16K11307
[Journal Article] Effect of the Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) on Corneal Endothelial Wound Healing.2016
- Author(s)
  Okumura N, Okazaki Y, Inoue R, Kakutani K, Nakano S, Kinoshita S, Koizumi N
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 57(3) Issue: 3 Pages: 1284-1292
- DOI
  10.1167/iovs.15-18586
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K10885, KAKENHI-PROJECT-16K11307
[Journal Article] Density-gradient centrifugation enables the purification of cultured corneal endothelial cells for cell therapy by eliminating senescent cells2015
- Author(s)
  Okumura N, Kusakabe A, Hirano H, Inoue R, Okazaki Y, Nakano S, Kinoshita S, Koizumi N
- Journal Title
  
  Sci Rep
  
  Volume: 5 Issue: 1 Pages: 15005-15005
- DOI
  10.1038/srep15005
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10885, KAKENHI-PROJECT-26670760
[Journal Article] Laminin-511 and 521 enable efficient in vitro expansion of human corneal endothelial cells.2015
- Author(s)
  Okumura N, Kakutani K, Numata R, Nakahara M, Schloetzer-Schrehardt U, Kruse F, Kinoshita S, Koizumi N
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 56 Issue: 5 Pages: 2933-2942
- DOI
  10.1167/iovs.14-15163
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670760
[Journal Article] Laminin-511 and 521 enable efficient in vitro expansion of human corneal endothelial cells2015
- Author(s)
  Okumura N, Kakutani K, Numata R, Nakahara M, Schloetzer-Schrehardt U, Kruse F, Kinoshita S, and Koizumi N
- Journal Title
  
  Invest Ophthalmol Vis Sci
  
  Volume: 未定
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670760
[Journal Article] 角膜疾患の未来医療2010
- Author(s)
  木下茂、小泉範子, 他
- Journal Title
  
  日本眼科学会雑誌
  
  Volume: 114 Pages: 161-199
- NAID
  10026261146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592083
[Journal Article] 臨床応用を目指した角膜内皮再生医療の開発2010
- Author(s)
  小泉範子
- Journal Title
  
  同志社大学生命医科学会報第2号
  
  Pages: 2-7
- NAID
  110008792409
- Data Source
  KAKENHI-PROJECT-20592083
[Journal Article] Enhancement on primate corneal endothelial cell survival in vitro by a ROCK inhibitor2009
- Author(s)
  Okumura N, Koizumi N, Kinoshita S, et al
- Journal Title
  
  Invest Ophthalmol Vis Sci. 50(8)
  
  Pages: 3680-3687
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592083
[Journal Article] Cultivated Corneal Endothelial Transplantation in a Primate : Possible Future Clinical Application in Corneal Endothelial Regenerative Medicine.2008
- Author(s)
  Koizumi N, Kinoshita S, et al.
- Journal Title
  
  Cornea. 27(8)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20592083
[Patent] TGF-β阻害剤の新規スクリーニング法2018
- Inventor(s)
  小泉範子, 奥村直毅
- Industrial Property Rights Holder
  学校法人同志社
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-16K11307
[Patent] カスパーゼ阻害活性を有する化合物,これらの化合物を含む,角膜内皮の症状,障害または疾患を治療または予防するための医薬およびその応用2018
- Inventor(s)
  小泉範子, 奥村直毅
- Industrial Property Rights Holder
  学校法人同志社
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-16K11307
[Patent] ｍTORインヒビターを含む,眼の症状,障害または疾患を治療または予防するための医薬およびその応用2018
- Inventor(s)
  小泉範子, 奥村直毅
- Industrial Property Rights Holder
  学校法人同志社
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Overseas
- Data Source
  KAKENHI-PROJECT-16K11307
[Patent] ｍＴＯＲインヒビターを含む、眼の症状、障害または疾患を治療または予防するための医薬およびその応用2017
- Inventor(s)
  小泉範子奥村直毅
- Industrial Property Rights Holder
  同志社大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-118619
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K11307
[Patent] ＴＧＦ－β阻害剤の新規スクリーニング法2017
- Inventor(s)
  小泉範子奥村直毅
- Industrial Property Rights Holder
  同志社大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-118615
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K11307
[Patent] カスパーゼ阻害活性を有する化合物、これらの化合物を含む、角膜内皮の症状、障害または疾患を治療または予防するための医薬およびその応用2017
- Inventor(s)
  小泉範子奥村直毅
- Industrial Property Rights Holder
  同志社大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-053235
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] フックス角膜内皮ジストロフィのモデルマウスにおけるTCF4ノックアウトの影響2024
- Author(s)
  伊東優, 奥村直毅, 天野光貴, 泉あやか, 大山裕貴, 伊川正人, 小泉範子
- Organizer
  角膜カンファランス2024. 第47回日本角膜学会総会・第38回日本角膜移植学会
- Data Source
  KAKENHI-PROJECT-22K09824
[Presentation] フックス角膜内皮ジストロフィモデルマウスの作製とトランスクリプトーム解析2023
- Author(s)
  上田瑞希，奥村直毅，中川達也，大山裕貴，千葉怜，立石あやな，天野光貴，泉あやか，伊川正人，小泉範子
- Organizer
  第47回日本角膜学会総会・第38回日本角膜移植学会
- Data Source
  KAKENHI-PROJECT-22K09824
[Presentation] Generation and RNA Sequencing Analysis of Potential Mouse Model for Fuchs Endothelial Corneal Dystrophy Harboring CTG Trinucleotide Intronic Repeat Expansion in Tcf4.2023
- Author(s)
  Ueda M, Okumura N, Nakagawa T, Oyama Y, Chiba S, Tateishi A, Amano K, Izumi A, Ikawa M, Koizumi N
- Organizer
  2023 Annual Meeting of the Association for Research in Vision and Ophthalmology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09824
[Presentation] フックス角膜内皮ジストロフィ患者由来角膜内皮細胞を用いたTCF4遺伝子の病態への関与の検討2023
- Author(s)
  西内豪，奥村直毅，中川達也，中原マキ子，Theofilos Tourtas，Ursula Schloetzer-Schrehardt，Friedrich Kruse，Prema Padmanabhan，Sailaja Elchuri，Amit Chatterjee，Narayanan Janakiraman，Gajanan Sathe，Vivek Ghose，小泉範子
- Organizer
  第75回日本細胞生物学会大会
- Data Source
  KAKENHI-PROJECT-22K09824
[Presentation] 角膜内皮疾患に対する再生医療と創薬研究（特別講演）2023
- Author(s)
  小泉範子
- Organizer
  第456回大阪眼科集談会
- Invited
- Data Source
  KAKENHI-PROJECT-22K09824
[Presentation] RNA-Sequencing of Knock-in Mice Harboring CTG Trinucleotide Repeat Expansion in TCF4 as a Fuchs Endothelial Corneal Dystrophy Model.2022
- Author(s)
  中川達也, 奥村直毅, 大山裕貴, 千葉怜, 立石あやな, 天野光貴, 上田瑞希, 泉あやか, 伊川正人, 小泉範子
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K09824
[Presentation] フックス角膜内皮ジストロフィモデルマウスの三塩基繰り返し配列による角膜内皮における遺伝子発現変動2022
- Author(s)
  中川達也, 奥村直毅, 大山裕貴, 千葉怜, 立石あやな, 天野光貴, 上田瑞希, 泉あやか, 伊川正人, 小泉範子
- Organizer
  NGS EXPO 2022
- Data Source
  KAKENHI-PROJECT-22K09824
[Presentation] フックス角膜内皮ジストロフィ患者角膜内皮におけるmTOR/S6K経路の活性化の検討.2021
- Author(s)
  6.大山裕貴, 奥村直毅, 小森裕也, 中野正和, 徳田雄市, Theofilos Tourtas, Friedrich E. Kruse, Matthias Zenkel, Ursula Schloetzer-Schrehardt, 小泉範子
- Organizer
  角膜カンファランス2021. 第45回日本角膜学会総会・第37回日本角膜移植学会
- Data Source
  KAKENHI-PROJECT-19K09983
[Presentation] Feasibility of mTOR inhibitor for the treatment of Fuchs endothelial corneal dystrophy.2019
- Author(s)
  Nakayama G, Okumura N, Oshima T, Ueda E, Watanabe K, T. Tourtas, U. Schlotzer-Schrehardt, F. E. Kruse, Koizumi N
- Organizer
  The Association for Research in Vision and Ophthalmology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09983
[Presentation] 角膜内皮細胞の小胞体ストレス応答におけるmitochondria-associated ER membranesの関与2019
- Author(s)
  松本紗季, 奥村直毅, 奥田浩和, Robert D. Young, Quantock AJ, 小泉範子
- Organizer
  角膜カンファランス2019第43回日本角膜学会総会・第35回日本角膜移植学会
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] 薬剤スクリーニングによるフックス角膜内皮ジストロフィの治療薬の探索2019
- Author(s)
  中川理咲子, 奥村直毅, 大西貴子, 大嶋剛史, 上田江美, 渡辺恭子, 小泉範子
- Organizer
  角膜カンファランス2019第43回日本角膜学会総会・第35回日本角膜移植学会
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] Drug discovery for the treatment of Fuchs corneal endothelial dystrophy by cellbased drug screening system.2019
- Author(s)
  Nakagawa R, Okumura N, Onishi T, Oshima T, Ueda E, Watanabe K, T. Tourtas, U. Schlotzer-Schrehardt, F. E. Kruse, Koizumi N
- Organizer
  The Association for Research in Vision and Ophthalmology 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09983
[Presentation] 再生医療と創薬で角膜内皮治療の未来を切り拓く2018
- Author(s)
  小泉範子
- Organizer
  第14回滋賀県眼科治療フォーラム
- Invited
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] Establishment of a drug screening system for Fuchs endothelial corneal dystrophy.2018
- Author(s)
  Oshima T, Okumura N, Onishi T, Ueda E, Watanabe K, Tourtas T, Schlötzer-Schrehardt U, Kruse FE, Koizumi N
- Organizer
  The Association for Research in Vision and Ophthalmology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] Involvement of mitochondria-associated endoplasmic reticulum membrane in the pathophysiology of Fuchs endothelial corneal dystrophy2018
- Author(s)
  Matsumoto S, Okumura N, Okuda H, Schlötzer-Schrehardt U, Kruse FE, Young RD, Quantock AJ, Koizumi N
- Organizer
  The 11th Joint Meeting of Japan-China-Korea Ophthalmologists
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] 角膜内皮における小胞体ストレス応答による細胞死.2017
- Author(s)
  奥田浩和, 奥村直毅, 北原美優, 橋本佳祐, 小泉範子
- Organizer
  角膜カンファランス2017第41回日本角膜学会総会・第33回日本角膜移植学会
- Place of Presentation
  アクロス福岡（福岡県・福岡市）
- Year and Date
  2017-02-17
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] Fuchs角膜内皮ジストロフィにおけるmitochondria-associated membranesの病態への関与.2017
- Author(s)
  奥田浩和, 奥村直毅, 松本紗季, Young Robert D, Quantock Andrew J, 小泉範子
- Organizer
  角膜カンファランス2018第42回日本角膜学会総会・第34回日本角膜移植学会
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] Activation of an intrinsic pathway by endoplasmic reticulum stress in corneal endothelial cells.2017
- Author(s)
  Okuda H, Okumura N, Kitahara M, Hashimoto K, Koizumi N:
- Organizer
  The Association for Research in Vision and Ophthalmology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] Fuchs角膜内皮ジストロフィの小胞体ストレスにおけるp38 MAPK経路の関与.2017
- Author(s)
  大西貴子, 奥村直毅, 橋本佳佑, 小泉範子
- Organizer
  角膜カンファランス2017第41回日本角膜学会総会・第33回日本角膜移植学会
- Place of Presentation
  アクロス福岡（福岡県・福岡市）
- Year and Date
  2017-02-16
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] フックス角膜内皮ジストロフィにおける小胞体ストレスに対するTGF-βシグナルの影響.2017
- Author(s)
  奥村直毅, 上田江美, Theofilos Tourtas, Friedrich E. Kruse, Ursula Schloetzer-Schrehardt, 小泉範子
- Organizer
  角膜カンファランス2017第41回日本角膜学会総会・第33回日本角膜移植学会
- Place of Presentation
  アクロス福岡（福岡県・福岡市）
- Year and Date
  2017-02-17
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] Involvement of p38 mitogen-activated protein kinase pathway in Fuchs endothelial corneal dystrophy.2017
- Author(s)
  Onishi T, Okumura N, Hashimoto K, Koizumi N
- Organizer
  The Association for Research in Vision and Ophthalmology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] Fuchs角膜内皮ジストロフィの治療薬開発を目指した薬剤スクリーニング法の確立.2017
- Author(s)
  大西貴子, 奥村直毅, 上田江美, 渡辺恭子, Tourtas Theofilos, Schloetzer-Schrehardt Ursula, Kruse Friedrich E., 小泉範子
- Organizer
  角膜カンファランス2018第42回日本角膜学会総会・第34回日本角膜移植学会
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] 基礎から臨床へ角膜内皮トランスレーショナル研究2017
- Author(s)
  小泉範子
- Organizer
  第46回関西医科大学眼科同窓会春の勉強会
- Invited
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] Feasibility of caspase inhibitor to treat Fuchs endothelial corneal dystrophy.2017
- Author(s)
  Endo M, Okumura N, Tourtas T, Schloetzer-Schrehardt U, Kruse FE, Koizumi N
- Organizer
  The Association for Research in Vision and Ophthalmology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] Feasibility of TGF-β inhibition for the treatment of Fuchs endothelial corneal dystrophy.2017
- Author(s)
  Okumura N, Hashimoto K, Okuda H, Ueda E, Tourtas T, Schloetzer-Schrehardt U, Kruse FE, Koizumi N
- Organizer
  The Association for Research in Vision and Ophthalmology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] 角膜内皮治療の最前線2017
- Author(s)
  小泉範子
- Organizer
  北海道眼科医会北海道ブロック講習会
- Invited
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] 水疱性角膜症に対する培養角膜内皮細胞移植の開発2016
- Author(s)
  小泉範子
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪, 大阪国際会議場
- Year and Date
  2016-03-18
- Invited
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] p38 MAPキナーゼ阻害剤のヒト角膜内皮細胞培養における有用性の検討.2016
- Author(s)
  本郷茜, 奥村直毅, 中原マキ子, 小泉範子
- Organizer
  角膜カンファランス2016 第40回日本角膜学会総会第32回日本角膜移植学会
- Place of Presentation
  長野, 軽井沢プリンスホテルウエスト
- Year and Date
  2016-02-18
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] Unfolded protein accumulation induced endoplasmic reticulum stress of corneal endothelial cells in Fuchs endothelial corneal dystrophy.2016
- Author(s)
  Okumura N, Hashimoto K, Kitahara M, Nakahara M, Kinoshita S, Tourtas T, Schloetzer-Schrehardt U, Kruse F, Koizumi N
- Organizer
  The Association for Research in Vision and Ophthalmology
- Place of Presentation
  シアトル（アメリカ合衆国）
- Year and Date
  2016-05-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] 培養細胞を用いた角膜内皮再生医療.2016
- Author(s)
  小泉範子
- Organizer
  角膜カンファランス2016 第40回日本角膜学会総会第32回日本角膜移植学会
- Place of Presentation
  長野, 軽井沢プリンスホテルウエスト
- Year and Date
  2016-02-18
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] p38 MAPキナーゼ阻害剤のヒト角膜内皮細胞培養における有用性の検討.2016
- Author(s)
  本郷茜, 奥村直毅, 中原マキ子, 小泉範子
- Organizer
  第15回日本再生医療学会総会
- Place of Presentation
  大阪, 大阪国際会議場
- Year and Date
  2016-03-17
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] 角膜内皮再生医療.2016
- Author(s)
  小泉範子
- Organizer
  第39回日本眼科手術学会学術総会
- Place of Presentation
  福岡, 福岡国際会議場
- Year and Date
  2016-01-31
- Invited
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] 培養角膜内皮細胞移植の治療効果に対する細胞密度の影響.2016
- Author(s)
  日下部綾香, 奥村直毅, 平野浩惇, 井上亮太, 岡崎友吾, 角谷和哉, 木下茂, 小泉範子
- Organizer
  角膜カンファランス2016 第40回日本角膜学会総会第32回日本角膜移植学会
- Place of Presentation
  長野, 軽井沢プリンスホテルウエスト
- Year and Date
  2016-02-18
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] Translational research for corneal endothelial regeneration.2016
- Author(s)
  Koizumi N
- Organizer
  The 5th Biennial Scientific Meeting Asia Cornea Society
- Place of Presentation
  ソウル（韓国）
- Year and Date
  2016-12-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11307
[Presentation] Cell-Based Therapy for Corneal Endothelial Regeneration.2016
- Author(s)
  Koizumi N
- Organizer
  the 31st Asia-Pacific Academy of Ophthalmology Congress (APAO 2016)
- Place of Presentation
  Taipei, Taiwan, Taipei International Convention Center (TICC)
- Year and Date
  2016-03-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] ラミニン511-E8フラグメントの角膜内皮細胞の基質接着性に対する影響2015
- Author(s)
  角谷和哉, 奥村直毅, 沼田諒平, Ursula Schloetzer-Schrehardt, Friedrich E. Kruse, 木下茂, 小泉範子
- Organizer
  角膜カンファランス2015 第39回日本角膜学会総会・第31回日本角膜移植学会
- Place of Presentation
  高知
- Year and Date
  2015-02-12
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] Purification of high cell density cultured corneal endothelial cell by density-gradient centrifugation.2015
- Author(s)
  Kusakabe A, Okumura N, Hirano H, Koizumi N, Kinoshita S
- Organizer
  Annual Meeting of the Association for Research in Vision and Ophthalmology 2015
- Place of Presentation
  Colorado, USA, Colorado Convention Center
- Year and Date
  2015-05-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] The feasibility of recombinant human laminin-511 E8 fragments for human corneal endothelial cell cultivation.2015
- Author(s)
  Kakutani K, Okumura N, Schlotzer-Schrehardt U, Kruse FE, Kinoshita S, Koizumi N
- Organizer
  Annual Meeting of the Association for Research in Vision and Ophthalmology 2015
- Place of Presentation
  Colorado, USA, Colorado Convention Center
- Year and Date
  2015-05-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] 培養角膜内皮細胞移植における移植細胞の細胞密度が治療効果に与える影響.2015
- Author(s)
  奥村直毅, 中野新一郎, 日下部綾香, 井上亮太, 岡崎友吾, 角谷和哉, 木下茂, 小泉範子
- Organizer
  第119回日本眼科学会総会
- Place of Presentation
  札幌, ロイトン札幌
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] 培養角膜内皮細胞移植におけるラミニン511-E8フラグメントの有用性.2015
- Author(s)
  角谷和哉, 奥村直毅, 井上亮太, 岡﨑友吾, 中野新一郎, 小泉範子
- Organizer
  第37回日本バイオマテリアル学会
- Place of Presentation
  京都, 京都テルサ
- Year and Date
  2015-11-10
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] Effect of the cell density of cultivated corneal endothelial cells on tissue engineering for the treatment of corneal endothelial dysfunction.2015
- Author(s)
  Okumura N, Nakano S, Kusakabe A, Inoue R, Okazaki Y, Kakutani K, Kinoshita S, Koizumi N
- Organizer
  Annual Meeting of the Association for Research in Vision and Ophthalmology 2015
- Place of Presentation
  Colorado, USA, Colorado Convention Center
- Year and Date
  2015-05-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] 培養角膜内皮細胞移植における移植細胞の細胞老化が治療効果に与える影響.2015
- Author(s)
  奥村直毅, 中野新一郎, 日下部綾香, 井上亮太, 岡﨑友吾, 角谷和哉, 木下茂, 小泉範子
- Organizer
  第37回日本バイオマテリアル学会
- Place of Presentation
  京都, 京都テルサ
- Year and Date
  2015-11-10
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] Cell based approach for the treatment of corneal endothelial dysfunction.2014
- Author(s)
  Koizumi N
- Organizer
  The International Society for Eye Research XXI Biennial Meeting
- Place of Presentation
  San Francisco, California, USA
- Year and Date
  2014-07-24
- Invited
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] Cell-injection therapy as a new therapeutic modality for corneal endothelial dysfunction.2014
- Author(s)
  Koizumi N
- Organizer
  The 2nd Asia-Pacific Glaucoma Congress -The 10th International Symposium of Ophthalmology Hong Kong
- Place of Presentation
  Wanchai, Hong Kong
- Year and Date
  2014-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] Ex vivo expansion of human corneal endothelial cells and Its clinical application for cell‐injection therapy.2014
- Author(s)
  Koizumi N
- Organizer
  The 4th Biennial Scientific Meeting Asia Cornea Society 2014
- Place of Presentation
  Taipei, Taiwan
- Year and Date
  2014-12-12
- Invited
- Data Source
  KAKENHI-PROJECT-26670760
[Presentation] New strategy for corneal endothelial tissue engineering.2011
- Author(s)
  小泉範子
- Organizer
  Asia-ARVO 2011
- Place of Presentation
  Singapore
- Year and Date
  2011-01-20
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] 3D Microstructure of nutrition canal network in rabbit lumbar vertebral endplate2011
- Author(s)
  Goto S, Yamaguchi T, Espinoza Orias AA, Koizumi N, Bae WC, Masuda K, Inoue N
- Organizer
  American Society of Mechanical Engineering 2011 Applied Mechanics and Material Conference
- Place of Presentation
  フェアモントホテル(シカゴ、米国)
- Year and Date
  2011-06-01
- Data Source
  KAKENHI-PROJECT-22591645
[Presentation] 3D Microstructure of nutrition canal network in rabbit lumbar vertebral endplate2011
- Author(s)
  S. Goto, T. Yamaguchi, A.A. Espinoza Orias, N. Koizumi, W.C. Bae, K. Masuda, N. Inoue
- Organizer
  American Society of Mechanical Engineering 2011 Applied Mechanics and Material Conference
- Place of Presentation
  シカゴ、米国
- Year and Date
  2011-06-01
- Data Source
  KAKENHI-PROJECT-22591645
[Presentation] カニクイザルを用いた角膜内皮再生医療の開発2010
- Author(s)
  小泉範子
- Organizer
  第14回予防衛生協会セミナー
- Place of Presentation
  つくば(平成21年度予防衛生協会研究奨励賞受賞講演)
- Year and Date
  2010-11-19
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] New strategy for corneal endothelial tissue engineering2010
- Author(s)
  Koizumi N
- Organizer
  2^<nd> Asia Cornea Society Biennial Scientific Meeting
- Place of Presentation
  The Westin Miyako, Kyoto, Japan
- Year and Date
  2010-11-30
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] The efficacy of a ROCK inhibitor containing corneal storage medium for corneal endothelial cells.2010
- Author(s)
  Takahashi H, Koizumi N, Okumura N, Ueno M, Sakamoto Y, Hamuro J, Kinoshita S
- Organizer
  Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
- Place of Presentation
  Fort Lauderdale, Florida, USA
- Year and Date
  2010-05-04
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] The existence of dead cells in corneal endothelium preserved with storage media.2010
- Author(s)
  Tanioka H, Kawasaki S, Adachi H, Inatomi T, Hieda O, Fukuoka H, Okumura N, Koizumi N, Iliakis B, Kinoshita S
- Organizer
  Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO)
- Place of Presentation
  Fort Lauderdale, Florida, USA
- Year and Date
  2010-05-04
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] Cultivated corneal endothelial transplantation in a primate for the future clinical application of corneal endothelial regenerative medicine2010
- Author(s)
  小泉範子
- Organizer
  Gordon Research Conference Biology & Pathobiology of the Cornea
- Place of Presentation
  Ventura, USA
- Year and Date
  2010-03-11
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] Cultivated monkey corneal endothelial cell transplantation using corneal lamellar graft.2009
- Author(s)
  N.Koizumi, et al.
- Organizer
  2009 Annual Meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale
- Place of Presentation
  Florida, USA
- Year and Date
  2009-05-04
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] Cultivated Monkey Corneal Endothelial Cell Transplantation Using Corneal Lamellar Graft.2009
- Author(s)
  Koizumi, N., et al.
- Organizer
  2009 Annual Meeting of the Association for Research in Vision and Ophthalmology
- Place of Presentation
  Greater Fort Lauderdale/Broward County Convention Center(米国)
- Year and Date
  2009-05-04
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] 霊長類を用いた培養角膜内皮移植術の開発2009
- Author(s)
  小泉範子
- Organizer
  第113回日本眼科学会総会
- Place of Presentation
  東京(日本眼科学会学術奨励賞記念講演)
- Year and Date
  2009-04-18
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] 霊長類を用いた培養角膜内皮移植術の開発2009
- Author(s)
  小泉範子, 他
- Organizer
  第8回日本再生医療学会総会
- Place of Presentation
  東京
- Year and Date
  2009-03-05
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] ヒト角膜実質を用いた培養角膜内皮移植術の試み2009
- Author(s)
  小泉範子, 他
- Organizer
  第33回角膜カンファランス・第25回角膜移植学会
- Place of Presentation
  大阪
- Year and Date
  2009-02-21
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] 角膜内皮再生医療の現状と展望2009
- Author(s)
  小泉範子
- Organizer
  第115回京都眼科学会
- Place of Presentation
  京都大学芝蘭会館(京都)
- Year and Date
  2009-09-06
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] Cultivated corneal endothelial transplantation in a primate for the future clinical application of corneal endothelial regenerative medicine.2009
- Author(s)
  Koizumi N
- Organizer
  the 107th Congress of the German Society of Ophthalmology
- Place of Presentation
  Congress Center Leipzig(ドイツ)
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] Cultivated corneal endothelial cell sheet transplantation in a primate mode.2008
- Author(s)
  小泉範子, et al
- Organizer
  XVIII International Congress of Eye Research (ICER)
- Place of Presentation
  Beijing, China
- Year and Date
  2008-09-25
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] Cryopreservation of Corneal Tissue Combined With Alginate Encapsulation.2008
- Author(s)
  Connon CJ (Koizumi N)
- Organizer
  2008 Annual Meeting of the Association for Research in Vision and Ophthalmology
- Place of Presentation
  Fort Lauderdale, Florida, U. S. A
- Year and Date
  2008-04-28
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] Cryopreservation of corneal tissue combined with alginate encapsulation.2008
- Author(s)
  Connon CJ, Koizumi N, et al.
- Organizer
  2008 Annual Meeting of the Association for Research in Vision and Ophthalmology, Fort Lauderdale
- Place of Presentation
  Florida, U.S.A.
- Year and Date
  2008-04-28
- Data Source
  KAKENHI-PROJECT-20592083
[Presentation] 霊長類の角膜内皮細胞と培養角膜内皮細胞における細胞周期制御分子の検討2007
- Author(s)
  奥村直毅、小泉範子, 他
- Organizer
  第111回日本眼科学会総会
- Place of Presentation
  大阪
- Year and Date
  2007-04-20
- Data Source
  KAKENHI-PROJECT-18791305
[Presentation] 霊長類角膜内皮細胞における細胞周期制御分子の発現2007
- Author(s)
  奥村直毅、小泉範子, 他
- Organizer
  第31回角膜カンファランス・第23回日本角膜移植学会
- Place of Presentation
  宮崎
- Year and Date
  2007-02-10
- Data Source
  KAKENHI-PROJECT-18791305

1. OKUMURA Naoki (10581499)

# of Collaborated Projects: 3 results

# of Collaborated Products: 34 results
2. 森和彦 (40252001)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. KINOSHITA Shigeru (30116024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
4. TORII Ryuzou (50106647)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. INOUE Nozomu (30193600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 西浦正敏 (70347459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Sato Takahiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. Friedrich Kruse

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. NAKANO Masakazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. Kruse Friedrich

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
11. Quantock Andrew

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koizumi Noriko 小泉 範子

KOIZUMI Noriko 小泉 範子

Research Projects

Research Products

Co-Researchers

3塩基繰り返し配列を有するマウスを用いたフックス角膜内皮ジストロフィの病態解明Principal Investigator

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Significance of mTOR signaling in the pathogenesis of Fuchs endothelial corneal dystrophyPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Involvement of endoplasmic reticulum stress in the pathophysiology of Fuchs endothelial corneal dystrophyPrincipal Investigator

Principal Investigator

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Research Institution

Investigation of molecular mechanism of cellular-senescence of corneal endothelial cells in association with cell-culture and its application for corneal endothelial tissue engineeringPrincipal Investigator

Principal Investigator

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Research Institution

選択的Rhoキナーゼ阻害剤を用いた培養角膜内皮細胞移植の開発Principal Investigator

Principal Investigator

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Research Institution

Three dimensional microstructure of spinal endplate: relationship between nano-scale structure of nutrition canal and biochemical characteristics of intervertebral disc

Principal Investigator

Project Period (FY)

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Research Institution

Corneal Tissue Engineering Using AlginatePrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

霊長類角膜内皮細胞の増殖制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

培養ヒト角膜内皮細胞シート自家移植の臨床応用を目指した開発

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Ocular surface疾患の予後を予測できるプロテインチップの開発Principal Investigator

Principal Investigator

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Research Field

Research Institution

[Book] encyclopedia of the eye.(The Ocular Surface : The surgical treatment for corneal epithelial stem cell deficiency, corneal epithelial defect, and peripheral corneal ulcer.)2011

Author(s)

Publisher

Data Source

[Journal Article] Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of TGF-β signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sustained activation of the unfolded protein response induces cell death in Fuchs endothelial corneal dystrophy2017

Koizumi Noriko 小泉範子

KOIZUMI Noriko 小泉範子