Niwa Hidetomo 丹羽英智

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Hidetomo Niwa 丹羽英智

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Researcher Number	20374845
Affiliation (Current)	2025: 弘前大学, 医学研究科, 客員研究員
Affiliation (based on the past Project Information) *help	2024: 弘前大学, 医学研究科, 准教授 2020 – 2021: 弘前大学, 医学研究科, 准教授 2015 – 2019: 弘前大学, 医学部附属病院, 講師 2015: 弘前大学, 医学部附属病院, 助教 2013 – 2014: 弘前大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 55050:Anesthesiology-related / Anesthesiology Except Principal Investigator Anesthesiology
Keywords	Principal Investigator 細胞傷害性 / オピオイド / レミフェンタニル / natural killer cell / ケタミン / general anesthesia / cancer surgery / remifentanil / 癌切除術 / natural killer cells … More / ナチュラルキラー細胞傷害活性 / 細胞傷害性アッセイ / 癌手術 / 抗癌免疫 / 麻酔薬 / 癌 / 肺癌 / 癌切除 / 抗炎症性サイトカイン / 炎症性サイトカイン / 癌転移 / 炎症性インターロイキン / NK細胞活性 / ケタミン麻酔 / 癌患者の予後 / ナチュラルキラー細胞 / 全静脈麻酔 / 前立腺癌 / 全身麻酔 / 癌切除手術 / natural killer 細胞 / natural killer 細胞活性 / 麻酔薬ケタミン / 脳悪性腫瘍 / 腫瘍増殖抑制 / 抗腫瘍作用 / ナチュラルキラー細胞活性 / NMDA受容体拮抗薬 / グリオーマ … More Except Principal Investigator オレキシン / メラニン凝集ホルモン / ラット / 敗血症 / ERAS / 麻酔 / 麻酔時間 / 鎮痛 / MCH / ノルアドレナリン / 内因性覚醒物質 / 睡眠 / 全身麻酔 Less

Can non-anesthetic effects of ketamine improve outcome of patients with cancer surgery?Principal Investigator
- Principal Investigator
  
  丹羽英智
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Hirosaki University
The quest for the appropriate anesthetic agents for patients undergoing cancer surgery-What is the best analgesic agent?Principal Investigator
- Principal Investigator
  
  NIWA HIDETOMO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Hirosaki University
Search for ideal combination of general anesthetics for patients undergoing cancer resection: To improve outcome of cancer patientsPrincipal Investigator
- Principal Investigator
  
  Niwa Hidetomo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology
- Research Institution
  Hirosaki University
Role of orexinergic neurons in sepsis
- Principal Investigator
  
  Hirota Kazuyoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Anesthesiology
- Research Institution
  Hirosaki University
Searching way of more gentle emergence from general anesthesia-An approach from anesthesiology and sleep to ERAS-
- Principal Investigator
  
  Tetsuya KUSHIKATA
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Anesthesiology
- Research Institution
  Hirosaki University
The effect of ketamine on natural killer cell cytotoxicityPrincipal Investigator
- Principal Investigator
  
  Hidetomo Niwa
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Anesthesiology
- Research Institution
  Hirosaki University

All 2022 2021 2020 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 悪性腫瘍手術と周術期管理2018
- Author(s)
  廣田和美，丹羽英智
- Total Pages
  142
- Publisher
  克誠堂出版
- ISBN
  9784771904606
- Data Source
  KAKENHI-PROJECT-16K20078
[Journal Article] Ketamine Does Not Change Natural Killer Cell Cytotoxicity in Patients Undergoing Cancer Surgery: Basic Experiment and Clinical Trial2022
- Author(s)
  Kubota Mirei、Niwa Hidetomo、Seya Kazuhiko、Kawaguchi Jun、Kushikata Tetsuya、Hirota Kazuyoshi
- Journal Title
  
  Journal of Oncology
  
  Volume: 2022 Pages: 1-8
- DOI
  10.1155/2022/8946269
- Data Source
  KAKENHI-PROJECT-19K09367
[Journal Article] Moderate rate of implementation of spinal anesthesia for cesarean section: does it improve neonatal well-being? A case control study2021
- Author(s)
  Sugo Yuki、Kubota Mirei、Niwa Hidetomo、Hirota Kazuyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 245-252
- DOI
  10.1038/s41598-020-80666-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09367
[Journal Article] Immunomodulation by ketamine as an adjunct to total intravenous anesthesia in patients undergoing minimally invasive radical prostatectomy: A randomized pilot trial2020
- Author(s)
  Kawaguchi Jun、Ota Daichi、Niwa Hidetomo、Sugo Yuki、Kushikata Tetsuya、Hirota Kazuyoshi
- Journal Title
  
  Molecular and Clinical Oncology
  
  Volume: 13 Issue: 2 Pages: 203-208
- DOI
  10.3892/mco.2020.2060
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09367
[Journal Article] In vitro and in vivo characterization of the bifunctional μ and δ opioid receptor ligand UFP‐5052018
- Author(s)
  Dietis N、Niwa H、Tose R、McDonald J、Ruggieri V、Filaferro M、Vitale G、Micheli L、Ghelardini C、Salvadori S、Calo G、Guerrini R、Rowbotham D J、Lambert D G
- Journal Title
  
  British Journal of Pharmacology
  
  Volume: 175 Issue: 14 Pages: 2881-2896
- DOI
  10.1111/bph.14199
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20078
[Journal Article] Pilot Study of Changes in Presepsin Concentrations Compared With Changes in Procalcitonin and C-Reactive Protein Concentrations After Cardiovascular Surgery.2017
- Author(s)
  Saito J, Hashiba E, Mikami A, Kudo T, Niwa H, Hirota K.
- Journal Title
  
  J Cardiothorac Vasc Anesth.
  
  Volume: 17 Issue: 4 Pages: 1262-1267
- DOI
  10.1053/j.jvca.2017.02.007
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10529, KAKENHI-PROJECT-15K15561
[Journal Article] Can tissue dielectric constant measurements assess circulating blood volume changes in patients undergoing haemodialysis?2017
- Author(s)
  Toyooka Ken-Taro、Niwa Hidetomo、Hashiba Eiji、Hirota Kazuyoshi
- Journal Title
  
  Clinical Physiology and Functional Imaging
  
  Volume: 38 Issue: 3 Pages: 497-501
- DOI
  10.1111/cpf.12446
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20078
[Journal Article] Ketamine suppresses the proliferation of rat C6 glioma cells2017
- Author(s)
  Niwa Hidetomo、Furukawa Ken-Ichi、Seya Kazuhiko、Hirota Kazuyoshi
- Journal Title
  
  Oncology Lett.
  
  Volume: 14 Issue: 4 Pages: 4911-4917
- DOI
  10.3892/ol.2017.6806
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10449, KAKENHI-PROJECT-16K20078
[Journal Article] Ketamine and propofol have opposite effects on postanesthetic sleep architecture in rats: relevance to the endogenous sleep-wakefulness substances orexin and melanin-concentrating hormone2016
- Author(s)
  Kushikata T, Sawada M, Niwa H, Kudo T, Kudo M, Tonosaki M, Hirota K.
- Journal Title
  
  Journal of anesthesia
  
  Volume: 30 Issue: 3 Pages: 437-43
- DOI
  10.1007/s00540-016-2161-x
- NAID
  40020854416
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26462327
[Journal Article] A modified paravertebral block to reduce risk of mortality in a patient with multiple rib fractures.2015
- Author(s)
  Hitoshi Yoshida, Shinya Yaguchi, Atsufumi Matsumoto, Hiroyuki Hanada, Hidetomo Niwa, Masatou Kitayama
- Journal Title
  
  The American journal of emergency medicine
  
  Volume: 33 Pages: 735-736
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861353
[Journal Article] Endogenous neuropeptides S tone nfluences sleep-awake rythm in rats2014
- Author(s)
  Oishi M, Kushikata T, Niwa H, Yakakoshi C, Ogasawara C, Calo G, Guerrini R, Hirota K
- Journal Title
  
  Neurosci Lett
  
  Volume: 23 Pages: 834-839
- DOI
  10.1016/j.neulet.2014.08.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861353
[Journal Article] Finger pulse oximetry detects an intense congestion.2014
- Author(s)
  Niwa H, Kimura F, Kudo T, Shito A, Hirota K
- Journal Title
  
  European journal of anasethesilogy
  
  Volume: 31 Issue: 2 Pages: 121-123
- DOI
  10.1097/eja.0b013e328363196a
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25861353
[Journal Article] Can anesthetic technique or drugs affect cancer recurrence in patients undergoing cancer surgery?2013
- Author(s)
  Niwa H
- Journal Title
  
  Journal of anesthesia
  
  Volume: 5 Issue: 5 Pages: 731-41
- DOI
  10.1007/s00540-013-1615-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861353
[Presentation] レミフェンタニルは、natiral killer 細胞活性を抑制するか？基礎実験の結果から2021
- Author(s)
  山崎佑真、丹羽英智、廣田和美
- Organizer
  日本麻酔科学会　第68回学術集会
- Data Source
  KAKENHI-PROJECT-19K09367
[Presentation] レミフェンタニルは、natural killer 細胞活性を抑制するか？基礎実験の結果から2021
- Author(s)
  山崎佑眞、丹羽英智、廣田和美
- Organizer
  第68回日本麻酔科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09367
[Presentation] Can ketamine be an optimal anesthetic drug for cancer resection? A randomized controlled clinical trial.2018
- Author(s)
  Hidetomo Niwa
- Organizer
  25th Biennial Congress of the European Association for Cancer Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20078
[Presentation] ケタミンの麻酔・鎮痛機序におけるオレキシン作動性神経の関与は異なる。-オレキシン遺伝子改変ラット（OX/ATA3 TG rat）を用いた研究-2016
- Author(s)
  外崎　充、櫛方哲也、丹羽英智、齋藤淳一、工藤隆司、廣田和美
- Organizer
  日本麻酔科学会第63回学術集会
- Place of Presentation
  福岡国際会議場（福岡県、福岡市）
- Year and Date
  2016-05-26
- Data Source
  KAKENHI-PROJECT-26462327
[Presentation] Ketamine disturbs post anesthesia sleep in aged rat–relevance to brain Orexin contents?2015
- Author(s)
  Tetsuya KUSHIKATA, MD, Ph. D, Izumi Miki, B Sc, Mitsuru Tonosaki , MD, Hidetomo Niwa, MD, Ph. D, Jyunichi Saito, MD, Ph. D, Kazuyoshi HIROTA, MD, Ph. D, FRCA
- Organizer
  The 9th lnternationaI Conference on Mechanisms of Anaesthesia
- Place of Presentation
  ボン市、ドイツ
- Year and Date
  2015-06-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462327
[Presentation] オレキシン作動性神経はケタミンの鎮痛作用に関与する-Transgenic Rat（OX/ATA3 TG rat）を用いた研究-
- Author(s)
  外崎充、櫛方哲也、佐々木剛範、丹羽英智、廣田和美、工藤隆司
- Organizer
  公益社団法人日本麻酔科学会第 61回学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-05-15 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-26462327

1. Tetsuya KUSHIKATA (80250603)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
2. Hirota Kazuyoshi (20238413)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. 橋場英二 (10374844)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 斎藤淳一 (90647413)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Ota Daichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. Kawaguchi Jun

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SEYA Kazuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 古川賢一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Niwa Hidetomo 丹羽 英智

Hidetomo Niwa 丹羽 英智

Research Projects

Research Products

Co-Researchers

Can non-anesthetic effects of ketamine improve outcome of patients with cancer surgery?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The quest for the appropriate anesthetic agents for patients undergoing cancer surgery-What is the best analgesic agent?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for ideal combination of general anesthetics for patients undergoing cancer resection: To improve outcome of cancer patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of orexinergic neurons in sepsis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Searching way of more gentle emergence from general anesthesia-An approach from anesthesiology and sleep to ERAS-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The effect of ketamine on natural killer cell cytotoxicityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 悪性腫瘍手術と周術期管理2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Ketamine Does Not Change Natural Killer Cell Cytotoxicity in Patients Undergoing Cancer Surgery: Basic Experiment and Clinical Trial2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Moderate rate of implementation of spinal anesthesia for cesarean section: does it improve neonatal well-being? A case control study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunomodulation by ketamine as an adjunct to total intravenous anesthesia in patients undergoing minimally invasive radical prostatectomy: A randomized pilot trial2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vitro and in vivo characterization of the bifunctional μ and δ opioid receptor ligand UFP‐5052018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pilot Study of Changes in Presepsin Concentrations Compared With Changes in Procalcitonin and C-Reactive Protein Concentrations After Cardiovascular Surgery.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Can tissue dielectric constant measurements assess circulating blood volume changes in patients undergoing haemodialysis?2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ketamine suppresses the proliferation of rat C6 glioma cells2017

Author(s)

Journal Title

Niwa Hidetomo 丹羽英智

Hidetomo Niwa 丹羽英智

[Presentation] Ketamine disturbs post anesthesia sleep in aged rat–relevance to brain Orexin contents?2015