HIROYUKI MIYACHI 宮地弘幸

… Alternative Names

MIYACHI Hiroyuki 宮地弘幸

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Researcher Number	20376643
Other IDs	https://orcid.org/0000-0002-3764-688X
Affiliation (based on the past Project Information) *help	2014 – 2015: 岡山大学, 医歯薬学総合研究科, 教授 2011 – 2015: 岡山大学, 医歯(薬)学総合研究科, 教授 2005 – 2006: 東京大学, 分子細胞生物学研究所, 助教授
Review Section/Research Field	Principal Investigator Drug development chemistry Except Principal Investigator 医薬分子機能学 / Biological pharmacy
Keywords	Principal Investigator ピラゾール / フェノキシブタン酸 / ＦＡＢＰ４ / ＦＡＢＰ３リガンド / ＦＡＢＰ３ / イソプラジオチン / 分子動力学シミュレーション法 / 非環状ビス（ビベンジル） / 膜障害 / リカルディン … More / ビス（ビベンジル） / 抗MRSA薬 / MRSA / フェニルプロピオン酸 / NOTCH / secretase / γセクレターゼ / チアゾリジンジオン / プロピオン酸 / PPAR / アルツハイマー … More Except Principal Investigator thalidomide / bioprobe / molecular design / enzyme inhibitor / antagonists / steroid hormone / structural development / nuclear receptor / 抗リウマチ活性 / 抗糖尿病活性 / 一酸化窒素 / シクロオキシゲナーゼ阻害剤 / 核内受容体 / エストロゲン / 抗アンドロゲン / レチノイド / 阻害剤 / シクロオキシゲナーゼ / ビタミンD_3 / 生物応答調節剤 / バチェラジン / チュブリン重合阻害剤 / 組胞分化誘導 / アンドロゲンアンタゴニスト / ビタミンDアンタゴニスト / プロテインキナーゼC / プロゲステロン / FXR / アンドロゲン / ビタミンD / ステロイド / PPAR / Farnesoid X Receptor (FXR) / Liver X Receptor (LXR) / 核内受容体リガンド / サリドマイド / 蛍光プローブ / 分子設計 / 酵素阻害剤 / アンタゴニスト / ステロイドホルモン / 構造展開 / 核内レセプター / 化学伝達 / ケトン体 / 塩素イオン / シナプス小胞 / ATP / グルタミン酸 / トランスポーター / 生化学 Less

宿主脂質動態制御に基づくＣ型肝炎治療の化学基盤Principal Investigator
- Principal Investigator
  
  宮地弘幸
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Okayama University
ビス(ビベンジル)型天然物は新たな膜障害性抗MRSA薬となり得るか!Principal Investigator
- Principal Investigator
  
  宮地弘幸
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Okayama University
シナプス伝達におけるグルタミン酸充填量制御メカニズムの構造生物学的解明とその応用
- Principal Investigator
  
  森山芳則
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  Okayama University
Explolation of gamma-secretase modulator based on metabolic nuclear receptorPrincipal Investigator
- Principal Investigator
  
  HIROYUKI MIYACHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Okayama University
Design and development of biological response modifiers
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo

All 2016 2015 2014 2013 2012 2011 2006 2005 Other

All Journal Article Presentation Patent

[Journal Article] Minimum structural requirements for cell membrane leakage-mediated anti-MRSA activity of macrocyclic bis(bibenzyl)s.2016
- Author(s)
  Fujii K, Morita D, Onoda K, Kuroda T, Miyachi H.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 23 Issue: 9 Pages: 2324-2327
- DOI
  10.1016/j.bmcl.2016.03.033
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293027
[Journal Article] Riccardin C derivatives cause cell leakage in Staphylococcus aureus.2015
- Author(s)
  Morita D, Sawada H, Ogawa W, Miyachi H, Kuroda T.
- Journal Title
  
  Biochim Biophys Acta.
  
  Volume: 1848 Issue: 10 Pages: 2057-2064
- DOI
  10.1016/j.bbamem.2015.05.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293027
[Journal Article] Anti-MRSA activity of isoplagiochin-type macrocyclic bis(bibenzyl)s is mediated through cell membrane damage2015
- Author(s)
  Kenji Onoda, Hiromi Sawada, Daichi Morita, Kana Fujii, Hiroaki Tokiwa, Teruo Kuroda, and Hiroyuki Miyachi
- Journal Title
  
  Bio. Med. Chem.
  
  Volume: 23(13) Issue: 13 Pages: 3309-3316
- DOI
  10.1016/j.bmc.2015.04.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460157, KAKENHI-PROJECT-26293027
[Journal Article] Structure-guideddesign,synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands2013
- Author(s)
  Beniyama Y, Matsuno K, Miyachi H
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 3 Pages: 1662-1666
- Data Source
  KAKENHI-PROJECT-23590128
[Journal Article] Design and synthesis of a series ofα-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility2013
- Author(s)
  Ohashi M, Oyama T, Putranto EW, Waku T, Nobusada H, Kataoka K, Matsuno K, Yashiro M, Morikawa K, Huh NH, Miyachi H
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 21(8) Pages: 2319-2332
- Data Source
  KAKENHI-PROJECT-23590128
[Journal Article] Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands.2013
- Author(s)
  Beniyama Y, Matsuno K, Miyachi H.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 23 Issue: 6 Pages: 1662-1666
- DOI
  10.1016/j.bmcl.2013.01.054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590128
[Journal Article] Peroxisome Proliferator-Activated Receptor delta Antagonists Inhibit Hepatitis C Virus RNA Replication2013
- Author(s)
  Ban S, Ueda Y, Ohashi M, Matsuno K, Ikeda M, Kato N, Miyachi H
- Journal Title
  
  Bioorg. Med. Chem. Lett
  
  Volume: 23(17) Pages: 4774-4778
- Data Source
  KAKENHI-PROJECT-23590128
[Journal Article] Peroxisome proliferator-activated receptor delta antagonists inhibit hepatitis C virus RNA replication.2013
- Author(s)
  Ban S, Ueda Y, Ohashi M, Matsuno K, Ikeda M, Kato N, Miyachi H.
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 23 Issue: 17 Pages: 4774-4778
- DOI
  10.1016/j.bmcl.2013.07.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590128
[Journal Article] Design, synthesis and in vitro evaluation of a series of a-substituted phenylpropanoic acid PPARy agonists to further investigate the stereochemistry-activity relationship2012
- Author(s)
  Masao Ohashi, et.al.
- Journal Title
  
  Bioorg. Med Chem.
  
  Volume: 20 Issue: 21 Pages: 6375-6383
- DOI
  10.1016/j.bmc.2012.08.061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J07435, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23590128
[Journal Article] Design, synthesis and in vitro evaluation of a series ofα-substituted phenylpropanoic acid PPARγagonists to further investigate the stereochemistry-activity relationship2012
- Author(s)
  Ohashi M, Nakagome I, Kasuga J, Nobusada H, Matsuno K, Makishima M, Hirono S, Hashimoto Y, Miyachi H
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 20 Pages: 375-383
- Data Source
  KAKENHI-PROJECT-23590128
[Journal Article] Peroxisome proliferator-activated receptors (PPARs) have multiple binding points2012
- Author(s)
  Kuwabara N, Oyama T, Tomioka D, Ohashi M, Yanagisawa J, Shimizu T, Miyachi H.
- Journal Title
  
  J. Med.Chem.
  
  Volume: 55 Issue: 2 Pages: 893-902
- DOI
  10.1021/jm2014293
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590128, KAKENHI-PROJECT-23770105, KAKENHI-PLANNED-23116007
[Journal Article] Bidirectional fluorescence properties of pyrene-based peroxisome proliferator-activated receptor (PPAR) α/δ dual agonist.2012
- Author(s)
  Shintaro Ban　他７名
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 20 Issue: 11 Pages: 3460-3464
- DOI
  10.1016/j.bmc.2012.04.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23247016, KAKENHI-PROJECT-23590128, KAKENHI-PROJECT-24370046
[Journal Article] Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR)α-selective agonists2011
- Author(s)
  Ban S, Kasuga J, Nakagome I, Nobusada H, Takayama F, Hirono S, Kawasaki H, Hashimoto Y, Miyachi H
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 19 Pages: 3183-3191
- Data Source
  KAKENHI-PROJECT-23590128
[Journal Article] Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPARγ-Selective Agonists : Discovery of Reversed Stereochemistry-Activity Relationship2011
- Author(s)
  Ohashi M, Oyama T, Nakagome I, Satoh M, Nishio Y, Nobusada H, Hirono S, Morikawa K, Hashimoto Y, Miyachi H
- Journal Title
  
  J. Med. Chem
  
  Volume: 54 Pages: 331-341
- Data Source
  KAKENHI-PROJECT-23590128
[Journal Article] Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferators-activated receptor α/σ dual agonists.2006
- Author(s)
  J.Kasuga, M.Makishima, Y.Hashimoto, H.Miyachi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 16・3
  
  Pages: 554-558
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Novel non-steroidal/non-anilide type androgen antagonists : discovery of 4-substituted pyrrole-2-carboxamides as a new scaffold for androgen receptor ligand.2005
- Author(s)
  K.Wakabayashi, H.Miyachi, Y.Hashimoto, A.Tanatani
- Journal Title
  
  Bioorganic & Medicinal Chemistry 13・8
  
  Pages: 2837-2846
- Data Source
  KAKENHI-PROJECT-14103018
[Patent] ポリアミンの化学伝達を司るトランスポーターの同定とその利用2015
- Inventor(s)
  森山芳則，表　弘志，宮地孝明，日浅未来
- Industrial Property Rights Holder
  森山芳則，表　弘志，宮地孝明，日浅未来
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-544325
- Filing Date
  2015-03-15
- Data Source
  KAKENHI-PROJECT-25253008
[Patent] アスコルビン酸トランスポーター2014
- Inventor(s)
  森山芳則，宮地孝明，表篠崎一雄ら
- Industrial Property Rights Holder
  森山芳則，宮地孝明，表篠崎一雄ら
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-155640
- Filing Date
  2014-08-04
- Data Source
  KAKENHI-PROJECT-25253008
[Patent] 葉緑体へのアスコルビン酸濃縮を司るトランスポーターの同定とその利用2013
- Inventor(s)
  森山芳則、宮地孝明、表弘志、黒森崇、篠崎一雄
- Industrial Property Rights Holder
  森山芳則、宮地孝明、表弘志、黒森崇、篠崎一雄
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-155640
- Filing Date
  2013-07-26
- Data Source
  KAKENHI-PROJECT-25253008
[Patent] 置換イソキサゾール誘導体2006
- Inventor(s)
  宮地弘幸, 貝沼雅彦, 橋本祐一
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Number
  2006-054501
- Filing Date
  2006-03-01
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Patent] 複素環誘導体2006
- Inventor(s)
  棚谷綾, 宮地弘幸, 中川亜弥, 橋本祐一
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Number
  2006-021770
- Filing Date
  2006-01-31
- Data Source
  KAKENHI-PROJECT-14103018
[Presentation] 膜障害性抗MRSA活性を有する大環状ビス(ビベンジル)型天然物誘導体の活性発現必須構造解析2016
- Author(s)
  藤井佳那，森田大地，斧田賢嗣，澤田紘実，黒田照夫，宮地弘幸
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26293027
[Presentation] 抗MRSA薬を天然に学び創る2015
- Author(s)
  宮地　弘幸
- Organizer
  難治性感染症シンポジウム
- Place of Presentation
  岡山大学50周年記念館
- Year and Date
  2015-02-12
- Invited
- Data Source
  KAKENHI-PROJECT-26293027
[Presentation] マスト細胞における小胞型ポリアミントランスポーターの発現と機能2015
- Author(s)
  竹内智也，原田結加，日浅未来，宮地孝明，表　弘志，森山芳則
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25
- Data Source
  KAKENHI-PROJECT-25253008
[Presentation] 膜障害性抗MRSA活性を有する大環状ビス(ビベンジル)型天然物誘導体の活性発現必須構造解析2015
- Author(s)
  藤井佳那，森田大地，斧田賢嗣，澤田紘実，黒田照夫，宮地弘幸
- Organizer
  創薬懇話会
- Place of Presentation
  グランドエクシブ鳴門ザ・ロッジ
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-26293027
[Presentation] 小胞型ポリアミントランスポーターの同定2014
- Author(s)
  表　弘志，日浅未来，宮地孝明，竹内智也，原田結加，森山佐和子，森山芳則
- Organizer
  第36回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2014-11-20
- Data Source
  KAKENHI-PROJECT-25253008
[Presentation] 質量分析による膜タンパク質の構造解析手法の構築2014
- Author(s)
  河上麻美代，宮地孝明，川上朝子，樹下成信，表弘志，森山芳則
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25253008
[Presentation] ショウジョウバエ小胞型ヌクレオチドトランスポーターの同定2014
- Author(s)
  加藤百合，宮地孝明，小泉拓也，Bram LARIDON，Patrick CALLAERTS，Koen NORGA，表弘志，森山芳則
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25253008
[Presentation] 中枢における新規小胞型ポリアミントランスポーターの発現および機能解析2014
- Author(s)
  日浅未来，宮地孝明，竹内智也，表　弘志，森山芳則
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15
- Data Source
  KAKENHI-PROJECT-25253008
[Presentation] 副腎における小胞型ヌクレオチドトランスポーターのATP濃縮と放出機構2014
- Author(s)
  宮地孝明，日浅未来，表弘志，森山芳則
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25253008
[Presentation] 血小板におけるVNUTを介したヌクレオチド蓄積機構2014
- Author(s)
  外川奈津子，日浅未来，宮地孝明，表弘志，森山芳則
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25253008
[Presentation] 神経細胞における小胞型ヌクレオチドトランスポーターの局在と機能2013
- Author(s)
  日浅未来, Max Larsson, 澤田啓介, 宮地孝明, 表弘志, Vidar Gundersen, 森山芳則
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25253008
[Presentation] 新規NOTCH-sparingγセクレターゼ阻害剤の創製2011
- Author(s)
  黒住元紀元、西尾淑暢、宮地弘幸、他
- Organizer
  創薬懇話会2011
- Place of Presentation
  ダイアモンド瀬戸内マリンホテル
- Data Source
  KAKENHI-PROJECT-23590128
[Presentation] Bis(bibenzyl) 型天然物を先導化合物とした新規膜障害性抗 MRSA 薬の創製
- Author(s)
  ○斧田賢嗣，森田大地，澤田紘実，石坪江梨花，松野研司，常盤広明，黒田照夫，宮地弘幸
- Organizer
  メディシナルケミストリーシンポジウム
- Place of Presentation
  神戸国際会議場
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-26293027
[Presentation] Riccardin誘導体の抗菌活性と作用機序の解析
- Author(s)
  森田大地、澤田紘実、小川和加野、宮地弘幸、黒田照夫
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293027
[Presentation] 構造生物学的構造活性相関に基づく創薬
- Author(s)
  宮地　弘幸
- Organizer
  CSJフェスタ
- Place of Presentation
  タワーホール船堀
- Year and Date
  2014-10-14 – 2014-10-16
- Invited
- Data Source
  KAKENHI-PROJECT-26293027

1. MATSUNO Kenji (50433214)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
2. HASHIMOTO Yuichi (90164798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. TANATANI Aya (40361654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. NAGASAWA Kazuo (10247223)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. ENDO Yasuyuki (80126002)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KAGECHIKA Hiroyuki (20177348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 森山芳則 (10150658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
8. 井上剛 (40370134)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 常盤広明 (10221433)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 黒田照夫 (80304327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
11. 袖岡幹子 (60192142)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 浦野泰照 (20292956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIROYUKI MIYACHI 宮地 弘幸

MIYACHI Hiroyuki 宮地 弘幸

Research Projects

Research Products

Co-Researchers

宿主脂質動態制御に基づくＣ型肝炎治療の化学基盤Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ビス(ビベンジル)型天然物は新たな膜障害性抗MRSA薬となり得るか!Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

シナプス伝達におけるグルタミン酸充填量制御メカニズムの構造生物学的解明とその応用

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Explolation of gamma-secretase modulator based on metabolic nuclear receptorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Design and development of biological response modifiers

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Minimum structural requirements for cell membrane leakage-mediated anti-MRSA activity of macrocyclic bis(bibenzyl)s.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Riccardin C derivatives cause cell leakage in Staphylococcus aureus.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-MRSA activity of isoplagiochin-type macrocyclic bis(bibenzyl)s is mediated through cell membrane damage2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Structure-guideddesign,synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands2013

Author(s)

Journal Title

Data Source

[Journal Article] Design and synthesis of a series ofα-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility2013

Author(s)

Journal Title

Data Source

[Journal Article] Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands.2013

Author(s)

Journal Title

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[Journal Article] Peroxisome Proliferator-Activated Receptor delta Antagonists Inhibit Hepatitis C Virus RNA Replication2013

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[Journal Article] Peroxisome proliferator-activated receptor delta antagonists inhibit hepatitis C virus RNA replication.2013

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[Journal Article] Design, synthesis and in vitro evaluation of a series of a-substituted phenylpropanoic acid PPARy agonists to further investigate the stereochemistry-activity relationship2012

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[Journal Article] Design, synthesis and in vitro evaluation of a series ofα-substituted phenylpropanoic acid PPARγagonists to further investigate the stereochemistry-activity relationship2012

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HIROYUKI MIYACHI 宮地弘幸

MIYACHI Hiroyuki 宮地弘幸

[Presentation] 膜障害性抗MRSA活性を有する大環状ビス(ビベンジル)型天然物誘導体の活性発現必須構造解析2016