Numoto Nobutaka 沼本修孝

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NUMOTO Nobutaka 沼本修孝

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Researcher Number	20378582
Other IDs
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Affiliation (Current)	2025: 岡山大学, 先鋭研究領域, 特任准教授 2025: 東京科学大学, その他の部局等, 非常勤講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 岡山大学, 異分野基礎科学研究所, 特任准教授 2021 – 2023: 東京医科歯科大学, 難治疾患研究所, 准教授 2018 – 2020: 東京医科歯科大学, 難治疾患研究所, 助教 2013 – 2016: 東京医科歯科大学, 難治疾患研究所, 助教 2009: 京都大学, 原子炉実験所, 助教
Review Section/Research Field	Principal Investigator Basic Section 43020:Structural biochemistry-related / Biophysics Except Principal Investigator Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 38030:Applied biochemistry-related / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Biological Sciences
Keywords	Principal Investigator X線結晶構造解析 / シグナル伝達 / クライオ電子顕微鏡 / B細胞 / 自己免疫疾患 / 構造変化 / 協同性 / ヘモグロビン / 常温結晶構造解析 / 時分割解析 … More / 酵素反応 / 単粒子解析 / 核酸 / 四次構造変化 / 顕微分光 / 四次構造 / 構造生物 / 中間体 … More Except Principal Investigator エンドソーム / T細胞非依存性抗体反応 / T細胞非依存性 / Bリンパ球 / 細胞内分解 / 抗体産生 / B細胞 / デキストラン / 多糖抗原 / 動的構造変化 / 金属イオン結合 / 構造機能相関 / PET分解 / 酵素 / 単粒子解析法 / クライオ電子顕微鏡法 / 水チャネル / 膜タンパク質 / 構造生理学 / ジスルフィド結合 / 超分子 / ナノバイオ / 硫化物 / 海産無脊椎動物 / 酸素 / 酸素親和性 / 金属イオン / 酸素協同性 / 環形動物 / ヘモグロビン / 超分子複合体 / 有鬚動物 / 協同性 / 立体構造 / 巨大ヘモグロビン Less

カルシウムイオンの結合と解離により制御されるPET分解酵素の反応過程Principal Investigator
- Principal Investigator
  
  沼本修孝
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Okayama University
Structural dynamics of cutinase Cut190 upon Ca2+ binding and molecular mechanism of PET degradation by Cut190
- Principal Investigator
  
  Oda Masayuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38030:Applied biochemistry-related
- Research Institution
  Kyoto Prefectural University
B細胞共受容体の自己抗原認識機構と自己免疫疾患抑制の構造相関Principal Investigator
- Principal Investigator
  
  沼本修孝
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Okayama University
  Tokyo Medical and Dental University
T cell-independent immune response and intracellular degradation
- Principal Investigator
  
  TSUBATA Takeshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Nihon University
  Tokyo Medical and Dental University
Structural physiology of channels based on development of cryo-electron microscopy
- Principal Investigator
  
  藤吉好則
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tokyo Medical and Dental University
Elucidation of specific recognition mechanism of self-antigen by B cell inhibitory co-receptor CD72Principal Investigator
- Principal Investigator
  
  Numoto Nobutaka
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Tokyo Medical and Dental University
Time-resolved analysis of oxygen-binding saturation and structural changes in the crystal of the giant hemoglobinPrincipal Investigator
- Principal Investigator
  
  Numoto Nobutaka
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Tokyo Medical and Dental University
Crystal structure analyses of cooperative oxygen-binding intermediates of giant hemoglobinPrincipal Investigator
- Principal Investigator
  
  NUMOTO Nobutaka
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  Tokyo Medical and Dental University
Structure and organization of nano-sized giant hemoglobin
- Principal Investigator
  
  FUKUMORI Yoshihiro
- Project Period (FY)
  2004 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kanazawa University

[Journal Article] Recognition Mechanism of a Novel Gabapentinoid Drug, Mirogabalin, for Recombinant Human α2δ1, a Voltage-Gated Calcium Channel Subunit2023
- Author(s)
  Kozai Daisuke、Numoto Nobutaka、Nishikawa Kouki、Kamegawa Akiko、Kawasaki Shohei、Hiroaki Yoko、Irie Katsumasa、Oshima Atsunori、Hanzawa Hiroyuki、Shimada Kousei、Kitano Yutaka、Fujiyoshi Yoshinori
- Journal Title
  
  Journal of Molecular Biology
  
  Volume: 435 Issue: 10 Pages: 168049-168049
- DOI
  10.1016/j.jmb.2023.168049
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H00451, KAKENHI-PROJECT-20K09193, KAKENHI-PROJECT-19H03165
[Journal Article] Structural analysis of the water channel AQP2 by single-particle cryo-EM2023
- Author(s)
  Kamegawa Akiko、Suzuki Shota、Suzuki Hiroshi、Nishikawa Kouki、Numoto Nobutaka、Fujiyoshi Yoshinori
- Journal Title
  
  Journal of Structural Biology
  
  Volume: 215 Issue: 3 Pages: 107984-107984
- DOI
  10.1016/j.jsb.2023.107984
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08304, KAKENHI-PROJECT-20H00451
[Journal Article] Improvement of the Thermostability and Activity of the PET-Degrading Enzyme Cut190 toward a Detailed Understanding and Application of the Enzymatic Reaction Mechanism2023
- Author(s)
  Numoto Nobutaka, Kamiya Narutoshi, Oda Masayuki
- Journal Title
  
  ACS Books, Sustainable Green Chemistry in Polymer Research
  
  Volume: 1 Pages: 89-100
- DOI
  10.1021/bk-2023-1450.ch006
- ISBN
  9780841296930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02120
[Journal Article] Structure Determination from Protein Crystal Clusters by Fully Automatic Data Collection2021
- Author(s)
  NUMOTO Nobutaka
- Journal Title
  
  Nihon Kessho Gakkaishi
  
  Volume: 63 Issue: 3 Pages: 229-231
- DOI
  10.5940/jcrsj.63.229
- NAID
  130008083582
- ISSN
  0369-4585, 1884-5576
- Year and Date
  2021-08-31
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06045
[Journal Article] Deoxygenated Structure of Invertebrate Giant Hemoglobin2015
- Author(s)
  沼本修孝，中川太郎，福森義宏，三木邦夫
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 55 Issue: 5 Pages: 266-268
- DOI
  10.2142/biophys.55.266
- NAID
  130005100826
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K20971
[Journal Article] The structure of a deoxygenated 400 kDa hemoglobin reveals ternary and quaternary structural changes of giant hemoglobins2014
- Author(s)
  Numoto, N., Nakagawa, T., Ohara, R., Hasegawa, T., Kita, A., Yoshida, T., Maruyama, T., Imai, K., Fukumori, Y., and Miki, K.
- Journal Title
  
  Acta Crystallogr D Biol Crystallogr.
  
  Volume: 70 Issue: 7 Pages: 1823-1831
- DOI
  10.1107/s1399004714008475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24570252, KAKENHI-PROJECT-25870200
[Journal Article] Structural basis for the heterotropic and homotropic interactions of invertebrate giant hemoglobin.2008
- Author(s)
  Numoto, N., Nakagawa, T., Kita, A., Sasayama, Y., Fukumori, Y., Miki, K.
- Journal Title
  
  Biochemistry 47
  
  Pages: 11231-11238
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16087205
[Journal Article] 巨大ヘモグロビンの構造と機能2008
- Author(s)
  沼本修孝, 中川太郎, 福森義宏, 三木邦夫
- Journal Title
  
  日本血液代替物学会誌「人工血液」 16
  
  Pages: 188-197
- Data Source
  KAKENHI-PLANNED-16087205
[Journal Article] Structure of the partially unliganded met state of 400 kDa hemoglobin: Insights into ligand-induced structural changes of giant hemoglobins.2008
- Author(s)
  Numoto, N., Nakagawa, T., Kita, A., Sasayama, Y., Fukumori, Y., Miki, K.
- Journal Title
  
  Proteins 73
  
  Pages: 113-125
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16087205
[Journal Article] Structure of the partially unliganded met state of 400 kDa hemoglobin : Insights into ligand-induced structural changes of giant hemoglobins2008
- Author(s)
  Numoto, N
- Journal Title
  
  Proteins 73
  
  Pages: 113-125
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16087205
[Journal Article] 巨大ヘモグロビンの構造と機能2008
- Author(s)
  沼本修孝
- Journal Title
  
  日本血液代替物学会誌「人工血液」 16
  
  Pages: 188-197
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16087205
[Journal Article] Structural basis for the heterotropic and homotropic interactions of invertebrate giant hemoglobin2008
- Author(s)
  Numoto, N
- Journal Title
  
  Biochemistry 47
  
  Pages: 11231-11238
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16087205
[Journal Article] 巨大ヘモグロビンの謎に迫る-X線結晶構造解析で構造と機能を解き明かせ!2006
- Author(s)
  沼本修孝他
- Journal Title
  
  化学 61・3
  
  Pages: 30-34
- Data Source
  KAKENHI-PLANNED-16087205
[Journal Article] 巨大ヘモグロビンの謎に迫る?X線結晶構造解析で構造と機能を解き明かせ!2006
- Author(s)
  沼本修孝、福森義宏、三木邦夫
- Journal Title
  
  化学 61
  
  Pages: 30-34
- Data Source
  KAKENHI-PLANNED-16087205
[Journal Article] Structure of an extracellular giant hemoglobin of the gutless beard worm Oligobrachia mashikoi.2005
- Author(s)
  Numoto, N., Nakagawa, T., Kita, A., Sasayama, Y., Fukumori, Y., Miki, K.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 102
  
  Pages: 14521-14526
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16087205
[Journal Article] Crystallization and preliminary X-ray crystallographic analysis of extracellular giant hemoglobin from pogonophoran Oligobrachia mashikoi.2005
- Author(s)
  Numoto, N., Nakagawa, T., Kita, A., Sasayama, Y., Fukumori, Y., Miki, K.
- Journal Title
  
  Biochim. Biophys. Acta 1750
  
  Pages: 173-176
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-16087205
[Journal Article] Crystallization and preliminary X-ray crystallographic analysis of extracellular giant hemoglobin from pogonophoran Oligobrachia mashikoi2005
- Author(s)
  N.Numoto et al.
- Journal Title
  
  Biochim.Biophys.Acta 1750
  
  Pages: 173-176
- Data Source
  KAKENHI-PLANNED-16087205
[Journal Article] Structure of an extracellular giant hemoglobin of the gutless beard worm Oligobrachia mashikoi2005
- Author(s)
  N.Numoto et al.
- Journal Title
  
  Proc.Natl.Acad.Sci.USA 102
  
  Pages: 14521-14526
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] PET分解酵素Cut190の高機能化と構造機能相関解析2024
- Author(s)
  近藤史弥、Gert-Jan Bekker、神谷成敏、沼本修孝、織田昌幸
- Organizer
  日本農芸化学会関西支部第529回講演会
- Data Source
  KAKENHI-PROJECT-21H02120
[Presentation] Structure and function analysis of human B cell inhibitory co-receptor CD722023
- Author(s)
  全熙斌、沼本修孝、鍔田武志、伊藤暢聡
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21K06045
[Presentation] PET分解酵素Cut190のCa2+結合部位に着目した構造機能相関解析2023
- Author(s)
  近藤史弥、Gert-Jan Bekker、神谷成敏、沼本修孝、織田昌幸
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21H02120
[Presentation] PET分解酵素Cut190のアロステリック反応機構に基づく機能向上変異体の合理的設計2023
- Author(s)
  沼本修孝、Gert-Jan Bekker、神谷成敏、織田昌幸、伊藤暢聡
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-21H02120
[Presentation] Structure analysis of human B cell inhibitory co-receptor CD722022
- Author(s)
  Quan X., Numoto N., Tsubata T., Ito N.
- Organizer
  The 60th Annual Meeting of the Biophysical Society of Japan
- Data Source
  KAKENHI-PROJECT-21K06045
[Presentation] B細胞抑制性共受容体CD72のリガンド認識の分子機構2022
- Author(s)
  沼本修孝，全熙斌，鍔田武志，伊藤暢聡
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K06045
[Presentation] Molecular mechanism of self-antigen recognition by the ligand binding domain of B cell inhibitory co-receptor CD722021
- Author(s)
  Numoto N., Hirata K., Akatsu C., Tsubata T., Ito N.
- Organizer
  25th Congress and General Assembly of the International Union of Crystallography
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06045
[Presentation] B細胞抑制因子CD72のクラスター結晶からの構造決定2020
- Author(s)
  沼本修孝、平田邦生、鍔田武志、伊藤暢聡
- Organizer
  日本結晶学会令和2年度年会
- Data Source
  KAKENHI-PROJECT-18K06078
[Presentation] B細胞抑制性因子の自己免疫疾患感受性アリルCD72cの結晶構造解析2020
- Author(s)
  沼本修孝、鍔田武志、伊藤暢聡
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K06078
[Presentation] B細胞抑制性因子CD72とSm/RNPの複合体形成様式の推測2018
- Author(s)
  沼本修孝，赤津ちづる，品川健朗，鍔田武志，伊藤暢聡
- Organizer
  第91回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K06078
[Presentation] 巨大ヘモグロビン酸素解離中間状態の解析2016
- Author(s)
  沼本修孝，中川太郎，伊藤暢聡，福森義宏，三木邦夫
- Organizer
  第16回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場（福岡県・福岡市）
- Year and Date
  2016-06-09
- Data Source
  KAKENHI-PROJECT-15K20971
[Presentation] 生物系BL利用と最近の成果について -BL38B1での on line 顕微分光測定-2016
- Author(s)
  沼本修孝
- Organizer
  SPRUC放射光構造生物学研究会第6回研究会
- Place of Presentation
  関西学院大学神戸三田キャンパス（兵庫県・三田市）
- Year and Date
  2016-08-29
- Invited
- Data Source
  KAKENHI-PROJECT-15K20971
[Presentation] マシコヒゲムシ巨大ヘモグロビンの酸素解離中間体2016
- Author(s)
  沼本修孝，中川太郎，伊藤暢聡，福森義宏，三木邦夫
- Organizer
  日本結晶学会2016年度年会
- Place of Presentation
  茨城県立県民文化センター（茨城県・水戸市）
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-15K20971
[Presentation] 巨大ヘモグロビン酸素解離中間体のX線結晶構造と分光学的解析2016
- Author(s)
  沼本修孝，中川太郎，伊藤暢聡，福森義宏，三木邦夫
- Organizer
  第54回日本生物物理学会年会
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-15K20971
[Presentation] ヘモグロビン分子の多様性 -巨大ヘモグロビンの構造と協同性機構-2015
- Author(s)
  沼本修孝
- Organizer
  崎大学テニュアトラック推進機構医学系物質科学分野セミナー
- Place of Presentation
  宮崎大学（宮崎）
- Year and Date
  2015-03-23
- Invited
- Data Source
  KAKENHI-PROJECT-25870200
[Presentation] マシコヒゲムシ巨大ヘモグロビンのリガンド解離型構造2015
- Author(s)
  沼本修孝，中川太郎，喜田昭子，伊藤暢聡，福森義宏，三木邦夫
- Organizer
  日本結晶学会2015年度年会
- Place of Presentation
  大阪府立大学（大阪府・堺市）
- Year and Date
  2015-10-17
- Data Source
  KAKENHI-PROJECT-15K20971
[Presentation] 巨大ヘモグロビン結晶内における酸素解離過程2014
- Author(s)
  沼本修孝，中川太郎，喜田昭子，伊藤暢聡，福森義宏，三木邦夫
- Organizer
  第14回日本蛋白質科学会年会
- Place of Presentation
  ワークピア横浜（神奈川）
- Year and Date
  2014-06-27
- Data Source
  KAKENHI-PROJECT-25870200
[Presentation] 巨大ヘモグロビン結晶内でのoxy型からdeoxy型への移行2014
- Author(s)
  沼本修孝，中川太郎，喜田昭子，伊藤暢聡，福森義宏，三木邦夫
- Organizer
  第52回日本生物物理学会年会
- Place of Presentation
  札幌コンベンションセンター（北海道）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-25870200
[Presentation] 巨大ヘモグロビン結晶中での酸素結合状態の操作2013
- Author(s)
  沼本修孝・中川太郎・喜田昭子・伊藤暢聡・福森義宏・三木邦夫
- Organizer
  平成25年度日本結晶学会年会
- Place of Presentation
  熊本大学（熊本県熊本市）
- Data Source
  KAKENHI-PROJECT-25870200
[Presentation] サツマハオリムシV2巨大ヘモグロビン(分子量40万)の結晶構造2009
- Author(s)
  沼本修孝, 中川太郎, 福森義宏, 三木邦夫
- Organizer
  第47回日本生物物理学会年会
- Place of Presentation
  アスティ徳島(徳島)
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] サツマハオリムシV2ヘモグロビンのX線結品構造解析2009
- Author(s)
  沼本修孝, 中川太郎, 福森義宏, 三木邦夫
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸国際展示場(兵庫)
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] サツマハオリムシV2巨大ヘモグロビン(分子量40万)の結晶構造2009
- Author(s)
  沼本修孝, 中川太郎, 福森義宏, 三木邦夫
- Organizer
  第47回日本生物物理学会年会
- Place of Presentation
  アスティとくしま(徳島)
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] サツマハオリムシV2ヘモグロビンのX線結晶構造解析2009
- Author(s)
  沼本修孝, 中川太郎, 福森義宏, 三木邦夫
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(兵庫)
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] 巨大ヘモグロビン(400 kDa)のリガンド結合に伴う協同的な構造変化2009
- Author(s)
  沼本修孝, 中川太郎, 喜田昭子, 笹山雄一, 福森義宏, 三木邦夫
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本全日空ホテルニュースカイ(熊本)
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] 巨大ヘモグロビン(400kDa)のリガンド結合に伴う協同的な構造変化2009
- Author(s)
  沼本修孝, 中川太郎, 福森義宏, 三木邦夫
- Organizer
  第9回日本蛋白質科学会年会
- Place of Presentation
  熊本全日空ホテル(熊本)
- Year and Date
  2009-05-22
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] 環形動物巨大ヘモグロビン(分子量360万)の5. 6 A分解能X線結晶構造解析2008
- Author(s)
  沼本修孝, 中川太郎, 福森義宏, 三木邦夫
- Organizer
  第31回秘本分子生物学会年会・第81回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド(兵庫)
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] サツマハオリムシ巨大ヘモグロビンの5.6A分解能結晶構造2008
- Author(s)
  沼本修孝
- Organizer
  日本生物物理学会第46回年会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] Ligand-induced structural changes of giant hemoglobin2008
- Author(s)
  Nobutaka Numoto
- Organizer
  XXI Congress of the International Union of Crystallography
- Place of Presentation
  大阪国際会議場
- Year and Date
  2008-08-24
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] サツマハオリムシ巨大ヘモグロビン(分子量360万)の5. 6 A分解能結晶構造2008
- Author(s)
  沼本修孝, 中川太郎, 福森義宏, 三木邦夫
- Organizer
  第46回日本生物物理学会年会
- Place of Presentation
  福岡国際会議場(福岡)
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] 無脊椎動物巨大ヘモグロビンの高分解能結晶構造2008
- Author(s)
  沼本修孝, 中川太郎, 喜田昭子, 笹山雄一, 福森義宏, 三木邦夫
- Organizer
  第21回日本放射光学会年会・放射光科学合同シンポジウム
- Place of Presentation
  立命館大学(滋賀)
- Year and Date
  2008-01-14
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] Ligand-induced structural changes of giant hemoglobin, XXI Congress and General Assembly of the International Union of Crystallography2008
- Author(s)
  Nobutaka Numoto, Taro Nakagawa, Akiko Kita, Yuichi Sasayama, Yoshihiro Fukumori, Kunio Miki
- Organizer
  invited lecture for Microsymposia "Large macromolecular complexes"
- Place of Presentation
  Osaka International Convention Center (Japan)
- Year and Date
  2008-08-24
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] マシコヒゲムシ巨大ヘモグロビンの金属結合型結晶構造2007
- Author(s)
  沼本修孝, 中川太郎, 喜田昭子, 笹山雄一, 福森義宏, 三木邦夫
- Organizer
  第7回日本蛋白質科学会年会
- Place of Presentation
  仙台国際センター(仙台)
- Year and Date
  2007-05-24
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] マシコヒゲムシ巨大ヘモグロビンの一部酸素結合型結晶構造2006
- Author(s)
  沼本修孝, 中川太郎, 喜田昭子, 笹山雄一, 福森義宏, 三木邦夫
- Organizer
  第6回日本蛋白質科学会年会
- Place of Presentation
  国立京都国際会館(京都)
- Year and Date
  2006-04-26
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] Crystal Structure of Extracellular Giant Hemoglobin of Pogonophoran Oligobrachia mashikoi2006
- Author(s)
  Nobutaka Numoto, Taro Nakagawa, Akiko Kita, Yuichi Sasayama, Yoshihiro Fukumori, Kunio Miki
- Organizer
  The 7th Conference of the Asian Crystallographic Association (AsCA' 06/CrSJ)
- Place of Presentation
  Epochal Tsukuba, (Japan)
- Year and Date
  2006-11-22
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] 巨大へモグロビンの分子会合機構2005
- Author(s)
  沼本修孝, 中川太郎, 喜田昭子, 笹山雄一, 福森義宏, 三木邦夫
- Organizer
  第43回日本生物物理学会年会
- Place of Presentation
  札幌コンベンションセンター(北海道)
- Year and Date
  2005-11-25
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] マシコヒゲムシ巨大ヘモグロビンの結晶構造2005
- Author(s)
  沼本修孝, 中川太郎, 喜田昭子, 笹山雄一, 福森義宏, 三木邦夫
- Organizer
  第5回日本蛋白質科学会年会
- Place of Presentation
  福岡国際会議場(福岡)
- Year and Date
  2005-06-30
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] Structure of a giant hemoglobin of the gutless beard worm Oligobrachia mashikoi2005
- Author(s)
  Nobutaka Numoto, Taro Nakagawa, Akiko Kita, Yuichi Sasayama, Yoshihiro Fukumori, Kunio Miki
- Organizer
  XX Congress of the International Union of Crystallography
- Place of Presentation
  Fortezza da Basso (Italy)
- Year and Date
  2005-08-28
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] Crystallographic Study of Multi Hemoglobin System from Oligobrachia mashikoi2004
- Author(s)
  Nobutaka Numoto, Taro Nakagawa, Akiko Kita, Yoshihiro Fukumori, Kunio Miki
- Organizer
  The 1st Pacific-Rim International Conference on Protein Science
- Place of Presentation
  Pacifico Yokohama (Japan)
- Data Source
  KAKENHI-PLANNED-16087205
[Presentation] 巨大ヘモグロビン結晶中での酸素解離に伴う構造変化
- Author(s)
  沼本修孝，中川太郎，喜田昭子，伊藤暢聡，福森義宏，三木邦夫
- Organizer
  日本結晶学会2014年度年会
- Place of Presentation
  東京大学（東京）
- Year and Date
  2014-11-01 – 2014-11-03
- Data Source
  KAKENHI-PROJECT-25870200
[Presentation] Partial oxygen-dissociation of crystalline giant hemoglobin
- Author(s)
  Numoto N., Nakagawa T., Kita A., Ito N., Fukumori Y., Miki K.
- Organizer
  XXIII Congress and General Assembly of the International Union of Crystallography
- Place of Presentation
  Palais des congrès de Montréal, Montreal (Canada)
- Year and Date
  2014-08-06 – 2014-08-07
- Data Source
  KAKENHI-PROJECT-25870200

1. FUKUMORI Yoshihiro (60135655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 23 results
2. Oda Masayuki (20318231)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. TSUBATA Takeshi (80197756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 金森正明 (20324064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 藤吉好則 (80142298)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 亀川亜希子 (50867554)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 谷村幸宏 (80546515)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 関口博史 (00401563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 神谷成敏 (80420462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. 宮ノ入洋平 (80547521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. スルタンソフィア・シェリル (20838437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 吉田尊雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Numoto Nobutaka 沼本 修孝

NUMOTO Nobutaka 沼本 修孝

Research Projects

Research Products

Co-Researchers

カルシウムイオンの結合と解離により制御されるPET分解酵素の反応過程Principal Investigator

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Structural dynamics of cutinase Cut190 upon Ca2+ binding and molecular mechanism of PET degradation by Cut190

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B細胞共受容体の自己抗原認識機構と自己免疫疾患抑制の構造相関Principal Investigator

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T cell-independent immune response and intracellular degradation

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Structural physiology of channels based on development of cryo-electron microscopy

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Elucidation of specific recognition mechanism of self-antigen by B cell inhibitory co-receptor CD72Principal Investigator

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Time-resolved analysis of oxygen-binding saturation and structural changes in the crystal of the giant hemoglobinPrincipal Investigator

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Crystal structure analyses of cooperative oxygen-binding intermediates of giant hemoglobinPrincipal Investigator

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Structure and organization of nano-sized giant hemoglobin

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[Journal Article] Recognition Mechanism of a Novel Gabapentinoid Drug, Mirogabalin, for Recombinant Human α2δ1, a Voltage-Gated Calcium Channel Subunit2023

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[Journal Article] Structural analysis of the water channel AQP2 by single-particle cryo-EM2023

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[Journal Article] Improvement of the Thermostability and Activity of the PET-Degrading Enzyme Cut190 toward a Detailed Understanding and Application of the Enzymatic Reaction Mechanism2023

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[Journal Article] Structure Determination from Protein Crystal Clusters by Fully Automatic Data Collection2021

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Numoto Nobutaka 沼本修孝

NUMOTO Nobutaka 沼本修孝