Kobayashi Nobuyuki 小林伸行

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KOBAYASHI Nobuyuki 小林伸行

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Researcher Number	20385321
Other IDs	https://orcid.org/0000-0001-8627-515X
Affiliation (Current)	2025: 東京慈恵会医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 東京慈恵会医科大学, 医学部, 准教授 2016 – 2019: 東京慈恵会医科大学, 医学部, 講師 2009 – 2015: Jikei University School of Medicine, 医学部, 助教 2014: 東京慈恵会医科大学, ウイルス学講座, 助教
Review Section/Research Field	Principal Investigator Psychiatric science / Basic Section 52030:Psychiatry-related Except Principal Investigator Basic Section 52030:Psychiatry-related / Psychiatric science
Keywords	Principal Investigator SITH-1 / 双極性障害 / うつ病 / 動物モデル / 気分障害 / バイオマーカー / 軽度認知障害 / 認知症 / エピジェネティクス / DNAメチル化 … More / アルツハイマー病 / HHV-6 / 炎症性サイトカイン / ヒトヘルペスウイルス6 / エピゲノム / VP26 / エネルギー代謝 / 単純ヘルペスウイルス1型 / COASY / 老年精神医学 / アルツハイマー病モデルマウス / ADモデルマウス / アミロイドβ / モデルマウス / 疲労 / 酸化ストレス / サイトカイン / ヒトヘルペスウイルス６ / BDNF / 潜伏感染 / 精神疾患動物モデル / 慢性疲労症候群 / アストロサイト … More Except Principal Investigator アルツハイマー病 / DNAメチル化 / 生物学的加齢 / アパシー / 治療反応性 / 認知症 / 神経精神症状 / BPSD / 候補遺伝子 / メチル化 / エピジェネティクス / プロモーター / 脳由来神経栄養因子 / エピジェティクス Less

生物学的加齢を用いたアルツハイマー病におけるアパシーのバイオタイピング
- Principal Investigator
  
  品川俊一郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Jikei University School of Medicine
Reconstruction of the assessment of behavioral and psychological symptoms in Alzheimer's disease patients using DNA methylation as an indicator
- Principal Investigator
  
  SHINAGAWA Shunichro
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Jikei University School of Medicine
Causes of epigenomic abnormalities in Alzheimer's disease and their implications for neurodegenerationPrincipal Investigator
- Principal Investigator
  
  Kobayashi Nobuyuki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52030:Psychiatry-related
- Research Institution
  Jikei University School of Medicine
Significance for DNA methylation in Alzheimer's DiseasePrincipal Investigator
- Principal Investigator
  
  Kobayashi Nobuyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Jikei University School of Medicine
Investigation of the mechanism for and psychiatric symptoms due to elevation of inflammatory cytokines in mood disorders.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Nobuyuki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Jikei University School of Medicine
Epigenetic alteration of Alzheimer disease candidate gene promoter region
- Principal Investigator
  
  NAGATA Tomoyuki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Psychiatric science
- Research Institution
  Jikei University School of Medicine
Study on mood disorder pathogenesis using a novel animal model of bipolar disorders expressing protein of human herpesvirus.Principal Investigator
- Principal Investigator
  
  KOBAYAHI Nobuyuki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Jikei University School of Medicine
Mood disorders associated with latent herpes virus infection in the brain.Principal Investigator
- Principal Investigator
  
  KOBAYASHI Nobuyuki
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Psychiatric science
- Research Institution
  Jikei University School of Medicine

[Journal Article] Identification of a strong genetic risk factor for major depressive disorder in the human virome2024
- Author(s)
  Kobayashi Nobuyuki、Shimada Kazuya、Ishii Azusa、Osaka Rui、Nishiyama Toshiko、Shigeta Masahiro、Yanagisawa Hiroyuki、Oka Naomi、Kondo Kazuhiro
- Journal Title
  
  iScience
  
  Volume: 27 Issue: 3 Pages: 109203-109203
- DOI
  10.1016/j.isci.2024.109203
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07876, KAKENHI-PROJECT-21K07553
[Journal Article] Alterations of neuropsychiatric symptoms in dementia patients during hospitalization in a dementia ward2023
- Author(s)
  Nagata Tomoyuki、Shinagawa Shunichiro、Kobayashi Nobuyuki、Kondo Kazuhiro、Shigeta Masahiro
- Journal Title
  
  Psychogeriatrics
  
  Volume: 23 Issue: 5 Pages: 888-890
- DOI
  10.1111/psyg.13003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07488, KAKENHI-PROJECT-21K07553
[Journal Article] Relationship between human herpesvirus 6 infection and inflammatory bowel disease using novel biomarker2023
- Author(s)
  Matsumoto Satohiro、Otaki Yuzo、Yoshida Yukio、Kobayashi Nobuyuki、Oka Naomi、Yanagisawa Hiroyuki、Kondo Kazuhiro
- Journal Title
  
  JGH Open
  
  Volume: 7 Issue: 11 Pages: 790-796
- DOI
  10.1002/jgh3.12992
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07553
[Journal Article] SARS-CoV-2 S1 protein causes brain inflammation by reducing intracerebral acetylcholine production2023
- Author(s)
  Oka Naomi、Shimada Kazuya、Ishii Azusa、Kobayashi Nobuyuki、Kondo Kazuhiro
- Journal Title
  
  iScience
  
  Volume: 26 Issue: 6 Pages: 106954-106954
- DOI
  10.1016/j.isci.2023.106954
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07876, KAKENHI-PROJECT-21K07553
[Journal Article] Suppressors of Cytokine Signaling Are Decreased in Major Depressive Disorder Patients2022
- Author(s)
  Kobayashi Nobuyuki、Shinagawa Shunichiro、Nagata Tomoyuki、Shigeta Masahiro、Kondo Kazuhiro
- Journal Title
  
  Journal of Personalized Medicine
  
  Volume: 12 Issue: 7 Pages: 1040-1040
- DOI
  10.3390/jpm12071040
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07553, KAKENHI-PROJECT-23K24596
[Journal Article] 特集ウイルス感染症に強くなる!-予防･診断･治療のポイント《総論》ウイルスの基礎知識-形態,感染様式などについて2022
- Author(s)
  小林伸行、近藤一博
- Journal Title
  
  耳鼻咽喉科・頭頸部外科
  
  Volume: 94 Issue: 8 Pages: 606-610
- DOI
  10.11477/mf.1411203083
- ISSN
  0914-3491, 1882-1316
- Year and Date
  2022-07-20
- Data Source
  KAKENHI-PROJECT-21K07553, KAKENHI-PROJECT-23K24596
[Journal Article] VP26, a herpes simplex virus type 1 capsid protein, increases DNA methylation in COASY promoter region2022
- Author(s)
  Osaka Rui、Kobayashi Nobuyuki、Shimada Kazuya、Ishii Azusa、Oka Naomi、Kondo Kazuhiro
- Journal Title
  
  Brain, Behavior, & Immunity - Health
  
  Volume: 26 Pages: 100545-100545
- DOI
  10.1016/j.bbih.2022.100545
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07553, KAKENHI-PROJECT-23K24596
[Journal Article] Neuroimaging-driven brain-age is associated with life satisfaction and resilience in cognitively normal elderly: A community-based study2022
- Author(s)
  Sone D, Beheshti I, Shinagawa S, Niimura H, Kobayashi N, Kida H, Shikimoto R, Noda Y, Nakajima S, Bun S, Mimura M, Shigeta M.
- Journal Title
  
  Translational Psychiatry
  
  Volume: 12 Issue: 1 Pages: 0-0
- DOI
  10.1038/s41398-022-01793-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07488, KAKENHI-PROJECT-21K07553, KAKENHI-PROJECT-20KK0193
[Journal Article] A case of V180I genetic mutation Creutzfeldt Jakob disease (CJD) with delusional misidentification as an initial symptom2021
- Author(s)
  Nagata Tomoyuki、Shinagawa Shunichiro、Kobayashi Nobuyuki、Kondo Kazuhiro、Shigeta Masahiro
- Journal Title
  
  Prion
  
  Volume: 16 Issue: 1 Pages: 7-13
- DOI
  10.1080/19336896.2021.2017701
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07553
[Journal Article] Blood DNA Methylation Levels in the WNT5A Gene Promoter Region: A Potential Biomarker for Agitation in Subjects with Dementia2021
- Author(s)
  Kobayashi Nobuyuki、Shinagawa Shunichiro、Nagata Tomoyuki、Tagai Kenji、Shimada Kazuya、Ishii Azusa、Oka Naomi、Shigeta Masahiro、Kondo Kazuhiro
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 81(4) Issue: 4 Pages: 1601-11
- DOI
  10.3233/jad-210078
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03891, KAKENHI-PROJECT-21K07553
[Journal Article] 【認知症の遺伝子研究のこれまでとこれから】総論　認知症のエピジェネティクス研究(解説/特集)2019
- Author(s)
  小林伸行、品川俊一郎
- Journal Title
  
  老年精神医学雑誌
  
  Volume: 30 Pages: 1208-1212
- Data Source
  KAKENHI-PROJECT-17K10318
[Journal Article] Attenuation of human herpesvirus 6B reactivation by aging2019
- Author(s)
  Kobayashi Nobuyuki、Nishiyama Toshiko、Yamauchi Takashi、Shimada Kazuya、Suka Machi、Kondo Kazuhiro、Yanagisawa Hiroyuki
- Journal Title
  
  Journal of Medical Virology
  
  Volume: 91 Issue: 7 Pages: 1335-1341
- DOI
  10.1002/jmv.25434
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03891, KAKENHI-PROJECT-17K10318
[Journal Article] Clinical significance of cancer-related fatigue in multiple myeloma patients2018
- Author(s)
  Suzuki Kazuhito、Kobayashi Nobuyuki、Ogasawara Yoji、Shimada Takaki、Yahagi Yuichi、Sugiyama Katsuki、Takahara Shinobu、Saito Takeshi、Minami Jiro、Yokoyama Hiroki、Kamiyama Yutaro、Katsube Atsushi、Kondo Kazuhiro、Yanagisawa Hiroyuki、Aiba Keisuke、Yano Shingo
- Journal Title
  
  International Journal of Hematology
  
  Volume: 108 Issue: 6 Pages: 580-587
- DOI
  10.1007/s12185-018-2516-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10318
[Journal Article] Increased interleukin-1β and basic fibroblast growth factor levels in the cerebrospinal fluid during human herpesvirus-6B (HHV-6B) encephalitis2017
- Author(s)
  Tamai Masato、Kobayashi Nobuyuki、Shimada Kazuya、Oka Naomi、Takahashi Mayumi、Tanuma Akiko、Tanemoto Tomohiro、Namba Hiroyuki、Saito Yoshihiro、Wada Yasuyuki、Okamoto Aikou、Ida Hiroyuki、Kondo Kazuhiro
- Journal Title
  
  Biochemical and biophysical research communications
  
  Volume: 486 Issue: 3 Pages: 706-711
- DOI
  10.1016/j.bbrc.2017.03.102
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10318, KAKENHI-PROJECT-15K08216, KAKENHI-PROJECT-26860946
[Journal Article] Caregiver burden and fatigue in caregivers of people with dementia: Measuring human herpesvirus (HHV)-6 and & -7 DNA levels in saliva,2016
- Author(s)
  Tohmi Osaki, Takako Morikawa, Hiroyuki Kajita, Nobuyuki Kobayashi, Kazuhiro Kondo, Kiyoshi Maeda.
- Journal Title
  
  Archives of Gerontology and Geriatrics
  
  Volume: 66 Pages: 42-48
- DOI
  10.1016/j.archger.2016.04.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461758, KAKENHI-PROJECT-15K08216, KAKENHI-PROJECT-26860946
[Journal Article] Usefulness of DNA Methylation Levels in COASY and SPINT1 Gene Promoter Regions as Biomarkers inDiagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment.2016
- Author(s)
  Kobayashi N, Shinagawa S, Nagata T, Shimada K, Shibata N, Ohnuma T, Kasanuki K, Arai H, Yamada H, Nakayama K, Kondo K.
- Journal Title
  
  PloS one
  
  Volume: 11 Issue: 12 Pages: e0168816-e0168816
- DOI
  10.1371/journal.pone.0168816
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08216, KAKENHI-PROJECT-26860946
[Journal Article] DNA methylation in the NCAPH2/LMF2 promoter region is associated with hippocampal atrophy in Alzheimer's disease and amnesic mild cognitive impairment patients.2016
- Author(s)
  Shinagawa S, Kobayashi N, Nagata T, Kusaka A, Yamada H, Kondo K, Nakayama K.
- Journal Title
  
  Neurosci Lett
  
  Volume: 629 Pages: 33-37
- DOI
  10.1016/j.neulet.2016.06.055
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08216, KAKENHI-PROJECT-26860946
[Journal Article] Genetic association between RAGE polymorphisms and Alzheimer's disease and Lewy body dementias in a Japanese cohort: a case-control study.2016
- Author(s)
  Takeshita Y, Shibata N, Kasanuki K, Nagata T, Shinagawa S, Kobayashi N, Ohnuma T, Suzuki A, Kawai E, Takayama T, Nishioka K, Motoi Y, Hattori N, Nakayama K, Yamada H, Arai H.
- Journal Title
  
  International Journal of Geriatric Psychiatry
  
  Volume: 4 Issue: 12 Pages: 1241-1246
- DOI
  10.1002/gps.4600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-16K09678, KAKENHI-PROJECT-26860946
[Journal Article] Human herpesvirus 6 and 7 are biomarkers for fatigue, which distinguish between physiological fatigue and pathological fatigue.2016
- Author(s)
  Aoki, R., Kobayashi, N., Suzuki, G., Kuratsune, H., Shimada, K., Oka, N., Takahashi, M., Yamadera, W., Iwashita, M., Tokuno, S., Nibuya, M., Tanichi, M., Mukai, Y., Mitani, K., Kondo, K., Ito, H., Nakayama, K.
- Journal Title
  
  Biochem. Biophy. Res. Commun.
  
  Volume: 478 Issue: 1 Pages: 424-430
- DOI
  10.1016/j.bbrc.2016.07.010
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02502, KAKENHI-PROJECT-15K08216, KAKENHI-PROJECT-15K09816, KAKENHI-PROJECT-26860946
[Journal Article] Development of Biomarkers Based on DNA Methylation in the NCAPH2/LMF2 Promoter Region for Diagnosis of Alzheimer’s Disease and Amnesic Mild Cognitive Impairment．2016
- Author(s)
  Nobuyuki Kobayashi, Shunichiro Shinagawa, Tomoyuki Nagata, Kazuya Shimada, Nobuto Shibata, Tohru Ohnuma, Koji Kasanuki, Heii Arai, Hisashi Yamada, Kazuhiko Nakayama, Kazuhiro Kondo.
- Journal Title
  
  PLoS ONE
  
  Volume: 11(1) Issue: 1 Pages: e0146449-e0146449
- DOI
  10.1371/journal.pone.0146449
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08216, KAKENHI-PROJECT-26860946
[Journal Article] Genetic Association between Presenilin 2 Polymorphisms and Alzheimer's Disease and Dementia of Lewy Body Type in a Japanese Population.2016
- Author(s)
  Suzuki A, Shibata N, Kasanuki K, et al.
- Journal Title
  
  Dement Geriatr Cogn Dis Extra.
  
  Volume: 16 Issue: 1 Pages: 90-97
- DOI
  10.1159/000444080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-26860946, KAKENHI-PROJECT-16K09678
[Journal Article] Association between DNA Methylation of the BDNF Promoter Region and Clinical Presentation in Alzheimer's Disease2015
- Author(s)
  Nagata T, Kobayashi N, Ishii J, Shinagawa S, Nakayama R, Shibata N, Kuerban B, Ohnuma T, Kondo K, Arai H, Yamada H, Nakayama K
- Journal Title
  
  Dement Geriatr Cogn Dis Extra
  
  Volume: 5 Issue: 1 Pages: 64-73
- DOI
  10.1159/000375367
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25893251, KAKENHI-PROJECT-26860946
[Journal Article] 疲労の尺度と疾病2015
- Author(s)
  小林伸行、近藤一博
- Journal Title
  
  臨牀透析
  
  Volume: 31 Pages: 1447-1452
- Data Source
  KAKENHI-PROJECT-26860946
[Journal Article] Plasma BDNF levels are correlated with aggressiveness in patients with amnestic mild cognitive impairment or Alzheimer disease.2014
- Author(s)
  Tomoyuki Nagata, Nobuyuki Kobayashi, Shunichiro Shinagawa, Hisashi Yamada, Kazuhiro Kondo, and Kazuhiko Nakayama
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: 121 Issue: 4 Pages: 433-441
- DOI
  10.1007/s00702-013-1121-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791355, KAKENHI-PROJECT-25893251
[Journal Article] Novel gene therapy viral vector using non-oncogenic lymphotropic herpesvirus.2013
- Author(s)
  Shimizu A, Kobayashi N, Shimada K, Oura K, Tanaka T, Okamoto A, Kondo K.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 2 Pages: e56027-e56027
- DOI
  10.1371/journal.pone.0056027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791355
[Journal Article] 新規組み換えヒトヘルペスウイルス6B(HHV-6B)を用いたHHV-6Bゲノム組み込み293T細胞の樹立とヒトゲノムDNAへの組み込み機構の解析2013
- Author(s)
  清水昭宏、小林伸行、嶋田和也、近藤一博
- Journal Title
  
  東京慈恵会医科大学雑誌
  
  Volume: 128巻(1号) Pages: 41-52
- NAID
  120005260142
- URL
  http://hdl.handle.net/10328/7746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791355
[Journal Article] Increase in the IgG avidity index due to herpes simplex virus type 1 reactivation and its relationship with cognitive function in amnestic mild cognitive impairment and Alzheimer's disease.2013
- Author(s)
  Kobayashi N
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 430 Issue: 3 Pages: 907-11
- DOI
  10.1016/j.bbrc.2012.12.054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659571, KAKENHI-PROJECT-23791354, KAKENHI-PROJECT-23791355
[Journal Article] Association between Neurotrophin-3 Polymorphisms and Executive Function in Japanese Patients with Amnestic Mild Cognitive Impairment and Mild Alzheimer Disease2012
- Author(s)
  Kobayashi N, Nagata T, Shinagawa S, Nakayama R, Kond K, Nakayama K, Yamada H.
- Journal Title
  
  Dement Geriatr Cogn Disord
  
  Volume: 34 Issue: 3-4 Pages: 190-197
- DOI
  10.1159/000343075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791354, KAKENHI-PROJECT-23791355
[Journal Article] 精神科領域から見た疼痛ー身体表現性障害と慢性疲労症候群ー2012
- Author(s)
  小林伸行　中山和彦　近藤一博
- Journal Title
  
  女性心身医学
  
  Volume: 16 Pages: 251-255
- Data Source
  KAKENHI-PROJECT-23791355
[Journal Article] 改良型遺伝子濃縮法によるヒトヘルペスウイルス6の前初期遺伝子および新規潜伏感染特異的遺伝子の同定2011
- Author(s)
  小川智生、川嶋公成、清水昭宏、小林伸行、近藤一博
- Journal Title
  
  東京慈恵会医科大学雑誌
  
  Volume: 126(1) Pages: 1-10
- NAID
  120003072812
- URL
  http://hdl.handle.net/10328/6567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791355
[Patent] アルツハイマー病を発症する可能性を判定するためのデータ収集方法及びキット2023
- Inventor(s)
  小林伸行
- Industrial Property Rights Holder
  学校法人慈恵大学
- Industrial Property Rights Type
  特許
- Filing Date
  2023
- Overseas
- Data Source
  KAKENHI-PROJECT-21K07553
[Patent] アルツハイマー病を発症する可能性を判定するためのデータ収集方法及びキット2022
- Inventor(s)
  小林伸行
- Industrial Property Rights Holder
  小林伸行
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-21K07553
[Patent] アルツハイマー病を発症する可能性を判定するためのデータ収集方法及びキット2022
- Inventor(s)
  小林伸行
- Industrial Property Rights Holder
  学校法人慈恵大学
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-21K07553
[Patent] アルツハイマー病を発症する可能性を判定するためのデータ収集方法及びキット2021
- Inventor(s)
  小林伸行
- Industrial Property Rights Holder
  学校法人慈恵大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-205192
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21K07553
[Presentation] 縦断的経過におけるBPSD重症度の推移：入院治療におけるNPI下位症状の変化2023
- Author(s)
  永田智行, 品川俊一郎, 小林伸行, 近藤一博, 繁田雅弘
- Organizer
  第38回日本老年精神医学会
- Data Source
  KAKENHI-PROJECT-21K07488
[Presentation] (シンポジウム10 うつ病,その病態の複雑系: overlap/difference/interaction) ヘルペスウイルスの潜伏感染によるうつ病発症リスクの増大2023
- Author(s)
  小林伸行
- Organizer
  第45回日本生物学的精神医学会
- Data Source
  KAKENHI-PROJECT-21K07553
[Presentation] (シンポジウム5 新しいうつ病の病態仮説 Beyond monoamines: 創薬を見据えてうつ病とウイルス感染2023
- Author(s)
  小林伸行
- Organizer
  第53回日本神経精神薬理学会
- Data Source
  KAKENHI-PROJECT-21K07553
[Presentation] 単純ヘルペスウイルス1型カプシドタンパクVP26によるCOASY プロモーター領域のDNAメチル化亢進2022
- Author(s)
  小林伸行、小坂瑠依、嶋田和也、石井梓、岡直美、近藤一博
- Organizer
  第69回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-21K07553
[Presentation] 血液バイオマーカーによる認知症診断の実現に向けて2022
- Author(s)
  小林伸行
- Organizer
  第2回日本認知症予防学会東京都支部学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07553
[Presentation] 客観的疲労評価法としての唾液中ヘルペスウイルスの測定2021
- Author(s)
  小林伸行, 岡直美, 近藤一博
- Organizer
  第17回日本疲労学会
- Data Source
  KAKENHI-PROJECT-21K07553
[Presentation] 単純ヘルペスウイルス1型感染によって引き起こされる宿主細胞のDNAメチル化変化の検討2021
- Author(s)
  小林伸行, 小坂瑠依, 嶋田和也, 近藤一博
- Organizer
  第68回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-21K07553
[Presentation] 一般労働者における時間外労働時間の増加による唾液中ヒトヘルペスウイルス(HHV-)6及びHHV-7 DNA量の低下2019
- Author(s)
  小林伸行、西山寿子、岡直美、近藤一博
- Organizer
  第15回日本疲労学会
- Data Source
  KAKENHI-PROJECT-17K10318
[Presentation] Attenuation of human herpesvirus (HHV-) 6B and HHV-7 reactivation by aging2019
- Author(s)
  "Nobuyuki Kobayashi, Kazuya Shimada, Toshiko Nishiyama, Takashi Yamauchi, Machi Suka, Hiroyuki Yanagisawa, Kazuhiro Kondo"
- Organizer
  第67回日本ウイルス学会 (The 66th Annual Meeting of the Japanese Society for Virology)
- Data Source
  KAKENHI-PROJECT-17K10318
[Presentation] DNAメチル化量を指標としたアルツハイマー病患者の行動・心理症状出現機序の検討2018
- Author(s)
  小林伸行、品川俊一郎、永田智行、繁田雅弘、近藤一博
- Organizer
  第37回日本認知症学会
- Data Source
  KAKENHI-PROJECT-17K10318
[Presentation] Association between overtime of ordinary workers and human herpesvirus (HHV-) 6 and HHV-7 in saliva2018
- Author(s)
  Nobuyuki Kobayashi, Toshiko Nishiyama, Kazuya Shimada, Machi Suka, Hiroyuki Yanagisawa, Kazuhiro Kondo
- Organizer
  第66回日本ウイルス学会 (The 66th Annual Meeting of the Japanese Society for Virology)
- Data Source
  KAKENHI-PROJECT-17K10318
[Presentation] シンポジウム精神神経疾患における加齢性変化の生理と病理　アルツハイマー病のおけるDNAメチル化変化の意義2018
- Author(s)
  小林伸行
- Organizer
  第114回日本精神神経学会
- Data Source
  KAKENHI-PROJECT-17K10318
[Presentation] 運動負荷及びうつ病患者における疲労の分子機構eIF2αリン酸化関連シグナルの検討2018
- Author(s)
  小林伸行、岡直美、髙橋麻弓、嶋田和也、近藤一博
- Organizer
  第14回日本疲労学会
- Data Source
  KAKENHI-PROJECT-17K10318
[Presentation] 分子機構から明らかにする疲労とストレスとの相違に関する検討2017
- Author(s)
  小林伸行、岡直美、髙橋麻弓、玉井将人、嶋田和也、近藤一博
- Organizer
  第13回日本疲労学会
- Data Source
  KAKENHI-PROJECT-26860946
[Presentation] 疲労を引き起こす分子メカニズムの解明2017
- Author(s)
  小林伸行、岡直美、髙橋麻弓、嶋田和也、近藤一博
- Organizer
  第134回成医会
- Data Source
  KAKENHI-PROJECT-26860946
[Presentation] 分子機構から明らかにする疲労とストレスとの相違に関する検討2017
- Author(s)
  小林伸行、岡直美、髙橋麻弓、玉井将人、嶋田和也、近藤一博
- Organizer
  第13回日本疲労学会
- Data Source
  KAKENHI-PROJECT-17K10318
[Presentation] さまざまな変性性認知症疾患におけるDNAメチル化変化とその臨床的意義の検討2017
- Author(s)
  小林伸行、品川俊一郎、永田智行、嶋田和也、柴田展人、大沼徹、笠貫浩史、新井平伊、繁田雅弘、近藤一博
- Organizer
  第36回日本認知症学会
- Data Source
  KAKENHI-PROJECT-26860946
[Presentation] さまざまな変性性認知症疾患におけるDNAメチル化変化とその臨床的意義の検討2017
- Author(s)
  小林伸行、品川俊一郎、永田智行、嶋田和也、柴田展人、大沼徹、笠貫浩史、新井平伊、繁田雅弘、近藤一博
- Organizer
  第36回日本認知症学会
- Data Source
  KAKENHI-PROJECT-17K10318
[Presentation] 疲労を引き起こす分子メカニズムの解明2017
- Author(s)
  小林伸行、岡直美、髙橋麻弓、嶋田和也、近藤一博
- Organizer
  第134回成医会
- Data Source
  KAKENHI-PROJECT-17K10318
[Presentation] 唾液中ヒトヘルペスウイルス(HHV-)6及びHHV-7量による病的疲労と生理的疲労との鑑別に関する検討.2016
- Author(s)
  小林伸行, 青木亮, 岡直美, 髙橋麻弓, 嶋田和也, 玉井将人, 山寺亘, 岩下正幸, 倉恒弘彦, 伊藤洋, 中山和彦, 近藤一博.
- Organizer
  第12回日本疲労学会
- Place of Presentation
  横浜
- Year and Date
  2016-05-20
- Data Source
  KAKENHI-PROJECT-26860946
[Presentation] Human herpesvirus 6 (HHV-) and HHV-7 reactivation in fatigue, which distinguishes between physiological fatigue and pathological fatigue.2016
- Author(s)
  Nobuyuki Kobayashi, Ryo Aoki, Hirohiko Kuratsune, Naomi Oka, Mayumi Takahashi, Kazuya Shimada, Wataru Yamadera, Masayuki Iwashita, Hiroshi Ito, Kazuhiko Nakayama, Kazuhiro Kondo.
- Organizer
  第64回日本ウイルス学会 (The 64th Annual Meeting of the Japanese Society for Virology)
- Place of Presentation
  札幌
- Year and Date
  2016-10-24
- Data Source
  KAKENHI-PROJECT-26860946
[Presentation] 血液中DNAメチル化変化を利用したアルツハイマー病と軽度認知機能障害の新規診断法に関する検討.2016
- Author(s)
  小林伸行, 品川俊一郎, 永田智行, 嶋田和也, 柴田展人, 大沼徹, 笠貫浩史, 新井平伊, 山田尚, 中山和彦, 近藤一博.
- Organizer
  第31回日本老年精神医学会
- Place of Presentation
  金沢
- Year and Date
  2016-06-23
- Data Source
  KAKENHI-PROJECT-26860946
[Presentation] 睡眠時無呼吸症候群を対象とした、HHV-6、HHV-7の再活性化メカニズムの検討2015
- Author(s)
  小林伸行、青木亮、嶋田和也、玉井将人、山寺亘、岩下正幸、伊藤洋、中山和彦、近藤一博
- Organizer
  第63回日本ウイルス学会
- Place of Presentation
  福岡
- Year and Date
  2015-11-23
- Data Source
  KAKENHI-PROJECT-26860946
[Presentation] 疲労・ストレスによるヒトヘルペスウイルス6の再活性化機構の検討2014
- Author(s)
  小林伸行、嶋田和也、岡直美、玉井将人、近藤一博.
- Organizer
  第62回日本ウイルス学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-10
- Data Source
  KAKENHI-PROJECT-26860946
[Presentation] 唾液中ヒトヘルペスウイルス量変化を利用した客観的疲労評価法による、生理的疲労と慢性疲労症候群との鑑別2014
- Author(s)
  小林伸行、岡直美、嶋田和也、鈴木豪、徳野慎一、丹生谷正史、三谷圭司、小原健幸、山本哲生、向井保雄、清水邦夫、丸山徹、立花正一、妻鳥元太郎、倉恒弘彦、杉野友啓、梶本修身、渡辺恭良、近藤一博.
- Organizer
  第10回日本疲労学会
- Place of Presentation
  大阪
- Year and Date
  2014-05-31
- Data Source
  KAKENHI-PROJECT-26860946
[Presentation] Novel human herpesvirus 6 stress-related latent protein induces depression and suicide.2014
- Author(s)
  Nobuyuki Kobayashi, Naomi Oka, Kazuya Shimada, Kazuhiro Kondo.
- Organizer
  The 39th Annual International Herpesvirus Workshop 2014
- Place of Presentation
  Kobe
- Year and Date
  2014-07-20
- Data Source
  KAKENHI-PROJECT-26860946
[Presentation] アルツハイマー型認知症の前駆段階において単純ヘルペスウイルス1型再活性化が発症に与える影響2013
- Author(s)
  小林伸行、岡直美、嶋田和也、近藤一博
- Organizer
  第61回日本ウイルス学会
- Place of Presentation
  神戸
- Year and Date
  2013-11-10
- Data Source
  KAKENHI-PROJECT-23791355
[Presentation] 疲労・ストレスによるヒトヘルペスウイルス(HHV-)6、7再活性化機構の検討2012
- Author(s)
  小林伸行、鈴木豪、徳野慎一、山本泰輔、波多野弁、清水昭宏、嶋田和也、立花正一、近藤一博
- Organizer
  第60回日本ウイルス学会
- Place of Presentation
  大阪
- Year and Date
  2012-11-13
- Data Source
  KAKENHI-PROJECT-23791355
[Presentation] Identification of SITH-1 as novel latent protein of Human Herpesvirus 6 (HHV-6) associated with chronic fatigue syndrome (CFS) and mood disorders2011
- Author(s)
  Kobayashi N, Shimada K, Shimizu A, Kondo K.
- Organizer
  International Union of Microbiological Societies (IUMS) 2011 Congress
- Place of Presentation
  Sapporo
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-23791355
[Presentation] 精神科領域から見た疼痛-身体表現性障害と慢性疲労症候群-2011
- Author(s)
  小林伸行
- Organizer
  第40回日本女性心身医学会学術集会
- Place of Presentation
  東京
- Year and Date
  2011-07-24
- Data Source
  KAKENHI-PROJECT-23791355
[Presentation] Identification of SITH-1 as novel latent protein of Human Herpesvirus 6 (HHV-6) associated with chronic fatigue syndrome (CFS) and mood disorders.2011
- Author(s)
  Nobuyuki Kobayashi, Kazuya Shimada, Akihiro Shimizu, Kazuhiro Kondo
- Organizer
  International Union of Microbiological Societies (IUMS) 2011 Congress
- Place of Presentation
  Sapporo
- Data Source
  KAKENHI-PROJECT-23791355
[Presentation] 精神科領域から見た疼痛-身体表現性障害と慢性疲労症候群-2011
- Author(s)
  小林伸行
- Organizer
  第40回日本女性心身医学会学術集会(招待講演)
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23791355
[Presentation] 新規ウイルス精製法を用いた、ヒトヘルペスウイルス6(HHV-6)再活性化機構の検討2010
- Author(s)
  小林伸行、嶋田和也、清水昭宏、近藤一博
- Organizer
  第58回日本ウイルス学会
- Place of Presentation
  徳島
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-21890260
[Presentation] Identification of a novel HHV-6 latent-protein associated with CFS and mood disorders.2010
- Author(s)
  近藤一博, 小林伸行
- Organizer
  Joint conference of the 33rd Annual Meeting of the Japan Neuroscience Society, the 53rd Annual Meeting of the Japanese Society for Neurochemistry, and the 20th Annual Meeting of Japanese Neural Network Society (Neuro2010)
- Place of Presentation
  Kobe
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-21890260
[Presentation] 新規ウイルス精製法を用いた、ヒトヘルペスウイルス6(HHV-6)再活性化機構の検討2010
- Author(s)
  小林伸行, 嶋田和也, 清水昭宏, 近藤一博
- Organizer
  第58回日本ウイルス学会
- Place of Presentation
  あわぎんホール(徳島県)
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-21890260
[Presentation] Identification of a novel HHV-6 latent-protein associated with CFS and mood disorders.2010
- Author(s)
  Kazuhiro Kondo, Nobuyuki Kobayashi
- Organizer
  Joint conference of the 33rd Annual Meeting of the Japan Neuroscience Society, the 53rd Annual Meeting of the Japanese Society for Neurochemistry, and the 20^<th> Annual Meeting of Japanese Neural Network Society (Neuro2010)
- Place of Presentation
  Kobe Convention Center(Kobe)(招待講演)
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-21890260
[Presentation] ヒトヘルペスウイルス(HHV)-6関連疾患における,多彩な精神症状の出現機構に関する検討2009
- Author(s)
  小林伸行
- Organizer
  第57回日本ウイルス学会
- Place of Presentation
  都市センターホテル(東京都)
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-21890260
[Presentation] ヒトヘルペスウイルス(HHV)-6潜伏感染特異的タンパク(SITH-1)と気分障害発症との関連2009
- Author(s)
  小林伸行
- Organizer
  第105回精神神経学会
- Place of Presentation
  神戸商工会議所(兵庫県)
- Year and Date
  2009-08-23
- Data Source
  KAKENHI-PROJECT-21890260
[Presentation] ヒトヘルペスウイルス(HHV)-6潜伏感染特異的タンパク(SITH-1)と気分障害発症との関連2009
- Author(s)
  小林伸行、中山和彦、近藤一博
- Organizer
  第105回精神神経学会
- Place of Presentation
  神戸
- Year and Date
  2009-08-23
- Data Source
  KAKENHI-PROJECT-21890260
[Presentation] Identification of a novel molecular mechanism and a major cause of fatigue.2009
- Author(s)
  近藤一博, 小林伸行
- Organizer
  The 36th Congress of the International Union of Physiological Sciences (IUPS2009)
- Place of Presentation
  Kyoto
- Year and Date
  2009-08-01
- Data Source
  KAKENHI-PROJECT-21890260
[Presentation] Identification of novel HHV-6 latent protein associated with CFS and mood disorders.2009
- Author(s)
  小林伸行, 嶋田和也, 清水昭宏, 近藤一博
- Organizer
  14th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus Infections
- Place of Presentation
  Kobe
- Year and Date
  2009-10-06
- Data Source
  KAKENHI-PROJECT-21890260
[Presentation] Identification of novel HHV-6 latent protein associated with CFS and mooddisorders.2009
- Author(s)
  Nobuyuki Kobayashi
- Organizer
  14th International Conference on Immunobiology and Prophylaxis of Human Herpesvirus Infections
- Place of Presentation
  Crowne Plaza ANA KOBE(Hyogo)
- Year and Date
  2009-10-06
- Data Source
  KAKENHI-PROJECT-21890260
[Presentation] ヒトヘルペスウイルス(HHV)-6関連疾患における,多彩な精神症状の出現機構に関する検討2009
- Author(s)
  小林伸行、嶋田和也、清水昭宏、近藤一博
- Organizer
  第57回日本ウイルス学会
- Place of Presentation
  東京
- Year and Date
  2009-10-26
- Data Source
  KAKENHI-PROJECT-21890260
[Presentation] Molecular mechanism of depressive disorder caused by HHV-6 latent infection.
- Author(s)
  Naomi Oka, Nobuyuki Kobayashi, Kazuya Shimada, Kazuhiro Kondo.
- Organizer
  The 39th Annual International Herpesvirus Workshop 2014
- Place of Presentation
  Kobe
- Year and Date
  2014-07-19 – 2014-07-20
- Data Source
  KAKENHI-PROJECT-26860946
[Presentation] Neurotrophin（NT）-3 遺伝子多型とアルツハイマー病との関連性
- Author(s)
  永田智行、品川俊一郎、柴田展人、小林伸行、Bolati Kuerban、大沼徹、近藤一博、新井平伊、中山和彦、山田尚
- Organizer
  第30回日本老年精神医学会
- Place of Presentation
  横浜
- Year and Date
  2016-06-13 – 2016-06-14
- Data Source
  KAKENHI-PROJECT-25893251
[Presentation] 疲労・ストレスによるヒトヘルペスウイルス(HHV-)6、7再活性化機構の検討.
- Author(s)
  小林伸行、鈴木豪、徳野慎一、山本泰輔、波多野弁、清水昭宏、嶋田和也、立花正一、近藤一博
- Organizer
  第60回日本ウイルス学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23791355
[Presentation] アルツハイマー型認知症の前駆段階において単純ヘルペスウイルス1型再活性化が発症に与える影響
- Author(s)
  小林伸行、岡直美、嶋田和也、近藤一博
- Organizer
  第61回日本ウイルス学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23791355

1. SHINAGAWA Shunichiro (90459628)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
2. NAGATA Tomoyuki (00408428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. YAMADA Hisashi (20130213)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
4. NAKAYAMA Kazuhiko (70155878)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 曽根大地 (10802051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. MAEDA Kiyoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. KAJITA Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 近藤一博

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
9. 西岡健弥

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 服部信孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 倉恒弘彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 嶋田和也

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Kobayashi Nobuyuki 小林 伸行

KOBAYASHI Nobuyuki 小林 伸行

Research Projects

Research Products

Co-Researchers

生物学的加齢を用いたアルツハイマー病におけるアパシーのバイオタイピング

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Reconstruction of the assessment of behavioral and psychological symptoms in Alzheimer's disease patients using DNA methylation as an indicator

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Causes of epigenomic abnormalities in Alzheimer's disease and their implications for neurodegenerationPrincipal Investigator

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Significance for DNA methylation in Alzheimer's DiseasePrincipal Investigator

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Investigation of the mechanism for and psychiatric symptoms due to elevation of inflammatory cytokines in mood disorders.Principal Investigator

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Epigenetic alteration of Alzheimer disease candidate gene promoter region

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Study on mood disorder pathogenesis using a novel animal model of bipolar disorders expressing protein of human herpesvirus.Principal Investigator

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Mood disorders associated with latent herpes virus infection in the brain.Principal Investigator

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[Journal Article] Identification of a strong genetic risk factor for major depressive disorder in the human virome2024

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[Journal Article] Alterations of neuropsychiatric symptoms in dementia patients during hospitalization in a dementia ward2023

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[Journal Article] Relationship between human herpesvirus 6 infection and inflammatory bowel disease using novel biomarker2023

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[Journal Article] SARS-CoV-2 S1 protein causes brain inflammation by reducing intracerebral acetylcholine production2023

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[Journal Article] Suppressors of Cytokine Signaling Are Decreased in Major Depressive Disorder Patients2022

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[Journal Article] 特集 ウイルス感染症に強くなる!-予防･診断･治療のポイント 《総論》 ウイルスの基礎知識-形態,感染様式などについて2022

Author(s)

Kobayashi Nobuyuki 小林伸行

KOBAYASHI Nobuyuki 小林伸行

[Journal Article] 特集ウイルス感染症に強くなる!-予防･診断･治療のポイント《総論》ウイルスの基礎知識-形態,感染様式などについて2022

[Journal Article] 【認知症の遺伝子研究のこれまでとこれから】総論　認知症のエピジェネティクス研究(解説/特集)2019