KOBAYASHI Jun 小林純

Researcher Number	20385404
Other IDs	https://orcid.org/0000-0003-0493-6386
External Links
Affiliation (Current)	2024: 東京女子医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2011 – 2024: 東京女子医科大学, 医学部, 講師 2009: 医学部, 助教 2009: Tokyo Women's Medical University, 助教 2007 – 2009: 東京女子医科大学, 医学部, 助教 2005 – 2006: 東京女子医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 90120:Biomaterials-related / Biomedical engineering/Biomaterial science and engineering / Biomedical engineering/Biological material science Except Principal Investigator Basic Section 53020:Cardiology-related / Science and Engineering / Science and Engineering
Keywords	Principal Investigator マイクロ流体 / mRNA送達 / 細胞シート / 再生医療 / 生体材料 / フォトリソグラフィー / 光重合 / 血管前駆細胞 / 血管内皮前駆細胞 / 脈管形成 … More / 血管新生 / リバーストランスフェクション / 細胞外マトリックス / ハイドロゲル / 肝細胞 / ヘパリン / 温度応答性高分子 / 組織工学 / 抗体 / 細胞分離 / フォトリソグラフイー / カンファーキノン / マスクレス露光措置 / 可視光 / バイオマテリアル / ポリジメチルシロキサン / 光造影 / ポリジメチンシロキサン / 光造形 / 液晶プロジェクタ / マスクレス / ラピッドプロトタイピング … More Except Principal Investigator 温度応答性高分子 / 組織工学 / 心筋細胞配向制御 / 配向制御 / 心筋細胞 / フォトリソグラフィー / 肝様組織構造 / 細胞シート / 微細加工 / 肝組織様構造 / 微細加工技術 / 肝小葉 / 成長因子 / 肝細胞シート / 軟組織 / 共培養 / 温度応答性細胞培養表面 / 肝細胞 / 細胞シート工学 / 細胞外マトリクス / 生体材料 / 組織・細胞 / 再生医学 / ラマン分光 / 超薄膜 / 電子線 / ニッチェ / 幹細胞 / 細胞外マトリックス / 基底膜 Less

Understanding the regulatory mechanisms of cardiomyocyte alignment control and maintenance
- Principal Investigator
  
  松浦勝久
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Tokyo Women's Medical University
Design of extracellular matrices for mRNA delivery to cell sheet tissuesPrincipal Investigator
- Principal Investigator
  
  小林純
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Tokyo Women's Medical University
Induction of vasculogenesis and angiogenesis in three-dimensional tissues by using protein expressions with mRNA deliveryPrincipal Investigator
- Principal Investigator
  
  Kobayashi Jun
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Tokyo Women's Medical University
Design of a next generation thermoresponsive culture system for creating functional cultured hepatic sheet tissuesPrincipal Investigator
- Principal Investigator
  
  Kobayashi Jun
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Tokyo Women's Medical University
Development of microfluidic device on antibody immobilized-thermoresponsive surfaces for cell sortingPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Jun
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Tokyo Women's Medical University
Fabrication of structually comlicated soft tissue such as liver-tissues and understanding its biological function of teh fabricated liver-tissue
- Principal Investigator
  
  YAMATO MASAYUKI
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  Tokyo Women's Medical University
Application of microfluidics for cell sheet-based tissue engineeringPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Jun
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tokyo Women's Medical University
Research of cell detachment behavior from nano-biomaterial surfaces
- Principal Investigator
  
  YAMATO Masayuki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Tokyo Women's Medical University
三次元マイクロ流路チップを高速プロトタイプするマスクレス光造形技術Principal Investigator
- Principal Investigator
  
  小林純
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Tokyo Women's Medical University

[Book] Hyper Bio Assembler for 3D Cellular Systems2015
- Author(s)
  FUKUMORI Kazuhiro, TAKAHASHI Hironobu, KOBAYASHI Jun, NAKAYAMA Masamichi, AKIYAMA Yoshikatsu, YAMATO Masayuki
- Total Pages
  349
- Publisher
  Springer
- Data Source
  KAKENHI-PLANNED-23106009
[Book] Biomaterials Surface Science2013
- Author(s)
  Kobayashi J, Okano T
- Total Pages
  11
- Publisher
  Wiley-VCH, Weinheim
- Data Source
  KAKENHI-PLANNED-23106009
[Book] 先端医療シリーズ37 「人工臓器・再生医療の最前線」第18章再生医療の基盤技術 4.微細加工技術, p.321-3242005
- Author(s)
  小林純 (分担執筆)
- Total Pages
  4
- Publisher
  先端医療技術研究所
- Data Source
  KAKENHI-PROJECT-17700403
[Journal Article] Preservation of heparin-binding EGF-like growth factor activity on heparin-modified poly(N-isopropylacrylamide)-grafted surfaces2021
- Author(s)
  KOBAYASHI Jun, ARISAKA Yoshinori, YUI Nobuhiko, YAMATO Masayuki, OKANO Teruo
- Journal Title
  
  RSC Advances
  
  Volume: 11 (59) Issue: 59 Pages: 37225-37232
- DOI
  10.1039/d1ra07317f
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03537, KAKENHI-PROJECT-18KK0415
[Journal Article] On-off affinity binding modulation on thermoresponsive polymer-grafted surfaces for capture and release of proteins and cells2017
- Author(s)
  Jun Kobayashi, Masayuki Yamato, Teruo Okano
- Journal Title
  
  Journal of Biomaterials Science, Polymer Edition
  
  Volume: 28 Issue: 10-12 Pages: 939-957
- DOI
  10.1080/09205063.2017.1295508
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K01317
[Journal Article] A heparin-modified thermoresponsive surface with heparin-binding epidermal growth factor-like growth factor for maintaining hepatic functions in vitro and harvesting hepatocyte sheets2016
- Author(s)
  Yoshinori Arisak, Jun Kobayashi, Kazuo Ohashi, Kohei Tatsumi, Kyungsook Kim, Yoshikatsu Akiyama, Masayuki Yamato, Teruo Okano
- Journal Title
  
  Regenerative Therapy
  
  Volume: 3 Pages: 97-106
- DOI
  10.1016/j.reth.2016.03.003
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K01317, KAKENHI-PLANNED-23106009
[Journal Article] Measurement of the dynamic behavior of thin poly(N-isopropylacrylamide) hydrogels and their phase transition temperatures measured using reflectometric interference spectroscopy2015
- Author(s)
  Okada F, Akiyama Y, Kobayashi J, Ninomiya H, Kanazawa H, Yamato M, Okano T
- Journal Title
  
  Journal of Nanoparticle Research
  
  Volume: 17 Issue: 3 Pages: 148-154
- DOI
  10.1007/s11051-015-2951-3
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23106009, KAKENHI-PROJECT-25293009
[Journal Article] Switching of cell growth/detachment on heparin-functionalized thermoresponsive surface for rapid cell sheet fabrication and manipulation2013
- Author(s)
  Arisaka Y, Kobayashi J, Yamato M, Akiyama Y, Okano T
- Journal Title
  
  Biomaterials
  
  Volume: 34 Pages: 4214-4222
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23106009
[Journal Article] Heparin-functionalized thermoresponsive surface: a versatile cell culture substrate for regulating multivalent affinity binding with heparin-binding proteins by temperature changes2013
- Author(s)
  Arisaka Y, Kobayashi J, Yamato M, Akiyama Y, Okano T
- Journal Title
  
  Organogenesis
  
  Volume: 9 Issue: 3 Pages: 125-7
- DOI
  10.4161/org.25588
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23106009
[Journal Article] Integrin αvβ3 regulates thrombopoietin-mediated maintenance of hematopoietic stem cells2012
- Author(s)
  Umemoto T, Yamato M, Ishihara J, Shiratsuchi Y, Utsumi M, Morita Y, Tsukui H, Terasawa M, Shibata T, Nishida K, Kobayashi Y, Petrich BG, Nakauchi H, Eto K, Okano T
- Journal Title
  
  Blood
  
  Volume: 119(1) Issue: 1 Pages: 83-94
- DOI
  10.1182/blood-2011-02-335430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21300160, KAKENHI-PROJECT-21390321, KAKENHI-PLANNED-23106004, KAKENHI-PLANNED-23106009, KAKENHI-PROJECT-23659514
[Journal Article] Modulation of graft architectures for enhancing hydrophobic interaction of biomolecules with thermoresponsive polymer-grafted surfaces2012
- Author(s)
  N.Idota, A.Kikuchi, J.Kobayashi, K.Sakai, T.Okano
- Journal Title
  
  Colloid Surf B
  
  Volume: (In press)
- NAID
  120006656756
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23106009
[Journal Article] Fabrication of a thermoresponsive cell culture dish : a key technology for cell sheet tissue engineering2010
- Author(s)
  J.Kobayashi, T.Okano
- Journal Title
  
  Science and Technology of Advanced Materials (accepted)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700398
[Journal Article] Development of the maskless photolithography device with an LCD-projector for fabrication of micropatterned surfaces2009
- Author(s)
  K.Itoga, J.Kobayashi, M.Yamato, T.Okano
- Journal Title
  
  IEEE Proceedings of International Symposium on Micro-NanoMechatronics and Human Science
  
  Pages: 2-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17076014
[Journal Article] Temperature-responsive intelligent interfaces for biomolecular separation and cell sheet engineering2009
- Author(s)
  K. Nagase, J. Kobayashi, T. Okano
- Journal Title
  
  Journal of the Royal Society Interface (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700398
[Journal Article] Development of the maskless photolithography device with an LCD-projector for fabrication of micropatterned surfaces2009
- Author(s)
  K. Itoga, J. Kobayashi, M. Yamato, T. Okano
- Journal Title
  
  IEEE Proceedings of International Symposium on Micro-NanoMechatronics and Human Science (MHS 2009)
  
  Pages: 368-372
- Data Source
  KAKENHI-PROJECT-17076014
[Journal Article] Temperature-responsive intelligent interfaces for biomolecular separation and cell sheet engineering2009
- Author(s)
  Kenichi Nagase, Jun Kobayashi, Teruo Okano
- Journal Title
  
  Journal of the Royal Society Interface 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700398
[Journal Article] Temperature-responsive glass coverslips with an ultrathin poly(N-isopropylacrylamide) layer2008
- Author(s)
  K. Fukumori, Y. Akiyama, M. Yamato, J. Kobayashi, K. Sakai, T. Okano Acta
- Journal Title
  
  Biomaterialia 5(1)
  
  Pages: 470-476
- Data Source
  KAKENHI-PROJECT-17076014
[Journal Article] Temperature-responsive glass coverslips with an ultrathin poly(N-isopr opylacrylamide) layer2008
- Author(s)
  K. Fukumori, Y. Akiyama, M. Yamato, J. Kobayashi, K. Sakai and T. Okano
- Journal Title
  
  Acta Biomaterialia 5(1)
  
  Pages: 470-476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17076014
[Journal Article] The use of biotin-avidin binding to facilitate biomodification of thermoresponsive culture surfaces2008
- Author(s)
  M. Nishi, J. Kobayashi, S. Pechmann, M. Yamato, Y. Akiyama, A. Kikuchi, K. Uchida, M. Textor, H. Yajima, *T. Okano
- Journal Title
  
  Biomaterials 28(36)
  
  Pages: 5471-5476
- Data Source
  KAKENHI-PROJECT-17076014
[Journal Article] 温度応答性表面による細胞シート工学の創生2007
- Author(s)
  小林純
- Journal Title
  
  医学のあゆみ 220(7)
  
  Pages: 541-541
- Data Source
  KAKENHI-PROJECT-17700403
[Journal Article] The use of biotin-avidin binding to facilitate biomodification of ther moresponsive culture surfaces2007
- Author(s)
  M. Nishi, J. Kobayashi, S. Pechmann, M. Yamato, Y. Akiyama A. Kikuchi, K. Uchida, M. Textor, H. Yajima and T. Okano
- Journal Title
  
  Biomaterials 28
  
  Pages: 5471-5476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17076014
[Journal Article] 温度応答性材料による細胞シート工学2007
- Author(s)
  小林純
- Journal Title
  
  材料の科学と工学 44(1)
  
  Pages: 2-2
- NAID
  10024352367
- Data Source
  KAKENHI-PROJECT-17700403
[Journal Article] 細胞シート工学および表面微細加工技術を利用した組織工学2006
- Author(s)
  小林純
- Journal Title
  
  応用物理 74(11)
  
  Pages: 1473-1476
- NAID
  10016763521
- Data Source
  KAKENHI-PROJECT-17700403
[Journal Article] Maskless liquid-crystal-display projection photolithography for improved design flexibility of cellular micropatterns2006
- Author(s)
  K.Itoga, J.Kobayashi, M.Yamato, A.Kikuchi, T.Okano
- Journal Title
  
  Biomaterials 27(15)
  
  Pages: 3005-3005
- Data Source
  KAKENHI-PROJECT-17076014
[Journal Article] Characterization of ultra-thin temperature-responsive polymer layer and its polymer thickness dependency on cell attachment/detachment properties
- Author(s)
  Kazuhiro Fukumori, Yoshikatsu Akiyama, Yoshikazu Kumashiro, Jun Kobayashi, Kiyotaka Sakai, Masayuki Yamato, Teruo Okano
- Journal Title
  
  (in press)
- Data Source
  KAKENHI-PROJECT-17076014
[Journal Article] Surface design of antibody-immobilized thermoresponsive cell culture dishes for recovering intact cells by low-temperature treatment
- Author(s)
  Kobayashi J, Hayashi M, Ohno T, Nishi M, Arisaka Y, Matsubara Y, Kakidachi H, Akiyama Y, Yamato M, Horii A, Okano T
- Journal Title
  
  J Biomed Mater Res Part A
  
  Volume: 102 Issue: 11 Pages: 3883-3893
- DOI
  10.1002/jbm.a.35064
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-23106009, KAKENHI-PROJECT-25750179
[Journal Article] Fabrication of a thermoresponsive cell culture dish: a key technology for cell sheet tissue engineering
- Author(s)
  Jun Kobayashi, Teruo Okano
- Journal Title
  
  Science and Technology of Advanced Materials (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20700398
[Journal Article] Temperature-responsive poly(N-isopropylacrylamide)-grafted microcarriers for large-scale noninvasive harvest of anchorage-dependent cells
- Author(s)
  A.Tamura, J.Kobayashi, M.Yamato, T.Okano
- Journal Title
  
  Biomaterials
  
  Volume: (Accepted)
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] ヘパリン修飾温度応答性高分子グラフト表面に結合したヘパリン結合EGF様増殖因子の活性維持2022
- Author(s)
  小林純, 有坂慶紀, 由井伸彦, 大和雅之, 岡野光夫
- Organizer
  第21回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-18KK0415
[Presentation] 血管新生因子を分泌する肝細胞シート組織の作製2022
- Author(s)
  小林純, LEE Hyukjin, 大和雅之, 岡野光夫
- Organizer
  第51回医用高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-18KK0415
[Presentation] Ex Vivo Gene Delivery for Fabrication of Hepatocyte Sheet Tissues Secreting Angiogenic Factors2022
- Author(s)
  KOBAYASHI Jun, LEE Hyukjin, YAMATO Masayuki, OKANO Teruo
- Organizer
  Society for Biomaterials/Japanese Society for Biomaterials Hawaii Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0415
[Presentation] ヘパリン修飾温度応答性高分子グラフト表面に結合したヘパリン結合EGF様増殖因子の活性維持2022
- Author(s)
  小林純, 有坂慶紀, 由井伸彦, 大和雅之, 岡野光夫
- Organizer
  第21回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-18H03537
[Presentation] Ex Vivo Gene Delivery for Fabrication of Hepatocyte Sheet Tissues Secreting Angiogenic Factors2022
- Author(s)
  KOBAYASHI Jun, LEE Hyukjin, YAMATO Masayuki, OKANO Teruo
- Organizer
  Society for Biomaterials/Japanese Society for Biomaterials Hawaii Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03537
[Presentation] 血管新生因子を分泌する肝細胞シート組織作製のための遺伝子デリバリー2021
- Author(s)
  小林純, LEE Hyukjin, 大和雅之, 岡野光夫
- Organizer
  第20回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-18KK0415
[Presentation] Messenger RNA delivery for fabrication of hepatocyte tissues secreting angiogenic factors2021
- Author(s)
  KOBAYASHI Jun, LEE Hyukjin, YAMATO Masayuki, OKANO Teruo
- Organizer
  The 43rd Annual Meeting of the Japanese Society for Biomaterials and The 8th Asian Biomaterials Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0415
[Presentation] Gene delivery for creation of hepatocyte sheets secreting angiogenic factors2021
- Author(s)
  KOBAYASHI Jun, LEE Hyukjin, YAMATO Masayuki, OKANO Teruo
- Organizer
  ISSCR/JSRM 2021 Tokyo International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0415
[Presentation] Gene delivery for creation of hepatocyte sheets secreting angiogenic factors2021
- Author(s)
  KOBAYASHI Jun, LEE Hyukjin, YAMATO Masayuki, OKANO Teruo
- Organizer
  ISSCR/JSRM 2021 Tokyo International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03537
[Presentation] Messenger RNA delivery for fabrication of hepatocyte tissues secreting angiogenic factors2021
- Author(s)
  KOBAYASHI Jun, LEE Hyukjin, YAMATO Masayuki, OKANO Teruo
- Organizer
  The 43rd Annual Meeting of the Japanese Society for Biomaterials and The 8th Asian Biomaterials Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03537
[Presentation] 血管新生因子を分泌する肝細胞シート組織作製のための遺伝子デリバリー2021
- Author(s)
  小林純, LEE Hyukjin, 大和雅之, 岡野光夫
- Organizer
  第20回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-18H03537
[Presentation] Creation of transplantable hepatocyte sheet tissues by using thermoresponsive cell culture surfaces2020
- Author(s)
  KOBAYASHI Jun, LEE Hyukjin, YAMATO Masayuki, OKANO Teruo
- Organizer
  11th World Biomaterials Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0415
[Presentation] 肝組織工学のためのバイオマテリアル2020
- Author(s)
  小林純
- Organizer
  第36回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18KK0415
[Presentation] Creation of transplantable hepatocyte sheet tissues by using thermoresponsive cell culture surfaces2020
- Author(s)
  KOBAYASHI Jun, LEE Hyukjin, YAMATO Masayuki, OKANO Teruo
- Organizer
  11th World Biomaterials Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03537
[Presentation] 肝組織工学のためのバイオマテリアル2020
- Author(s)
  小林純
- Organizer
  第36回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03537
[Presentation] 血管内皮細胞網形成のためのVEGF mRNA送達積層化細胞シート組織の作製2020
- Author(s)
  長瀬健一, 白木義基, 小林純, Lee:Hyukjin, 大和雅之, 金澤秀子
- Organizer
  第19回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-18H03537
[Presentation] 肝細胞シート組織の機能維持と生体移植のためのバイオマテリアル2019
- Author(s)
  小林純, Hyukjin Lee, 大和雅之, 岡野光夫
- Organizer
  第68回高分子討論会
- Data Source
  KAKENHI-PROJECT-18H03537
[Presentation] Temperature-dependent binding of growth factors and cells to a heparin-immobilized thermoresponsive surface2019
- Author(s)
  Jun Kobayashi, Yoshikatsu Akiyama, Masayuki Yamato, Teruo Okano
- Organizer
  Society For Biomaterials 2019 Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03537
[Presentation] 血管新生因子を分泌する肝細胞シート組織作製のための核酸送達2019
- Author(s)
  小林純, Hyukjin Lee, 大和雅之, 岡野光夫
- Organizer
  第18回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-18H03537
[Presentation] 三次元細胞シート組織内血管網様構造の構築を目指したVEGF mRNAの送達2019
- Author(s)
  白木義基, 小林純, Hyukjin Lee, 大和雅之, 長瀬健一, 金澤秀子
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18H03537
[Presentation] Temperature-dependent affinity binding of heparin-binding growth factors and cells with a heparin-immobilized thermoresponsive surface2018
- Author(s)
  Jun Kobayashi, Yoshikatsu Akiyama, Masayuki Yamato, Teruo Okano
- Organizer
  5th TERMIS World Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03537
[Presentation] 細胞増殖因子固定化温度応答性培養表面と細胞の相互作用の解析2018
- Author(s)
  小林純, 秋山義勝, 大和雅之, 岡野光夫
- Organizer
  第17回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-15K01317
[Presentation] 肝細胞シート組織からの血管新生因子分泌を誘導するための核酸送達2018
- Author(s)
  小林純, Hyukjin Lee, 大和雅之, 岡野光夫
- Organizer
  第40回日本バイオマテリアル学会大会
- Data Source
  KAKENHI-PROJECT-18H03537
[Presentation] ヘパリン修飾温度応答性表面と増殖因子および細胞とのアフィニティー結合制御2017
- Author(s)
  小林純, 秋山義勝, 大和雅之, 岡野光夫
- Organizer
  第39回日本バイオマテリアル学会大会
- Data Source
  KAKENHI-PROJECT-15K01317
[Presentation] Temperature-controlled capture and release of heparin-binding proteins and cells on heparin-immobilized thermoresponsive cell culture substrates2017
- Author(s)
  Jun Kobayashi, Yoshikatsu Akiyama, Masayuki Yamato, Teruo Okano
- Organizer
  Society For Biomaterials 2017 Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01317
[Presentation] 肝細胞シート培養および脱着のためのヘパリン修飾温度応答性培養表面とのアフィニティー結合制御2017
- Author(s)
  小林純, 秋山義勝, 大和雅之, 岡野光夫
- Organizer
  第66回高分子討論会
- Data Source
  KAKENHI-PROJECT-15K01317
[Presentation] Heparin-immobilized thermoresponsive cell culture surfaces for sustained stimulation of heparin-binding EGF and recovery of cultured cell sheets by lowering temperature2017
- Author(s)
  Jun Kobayashi, Yoshikatsu Akiyama, Masayuki Yamato, Teruo Okano
- Organizer
  28th Annual Conference of the European Society for Biomaterials
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01317
[Presentation] 肝細胞シート組織作製のためのヘパリン修飾温度応答性培養表面の設計2017
- Author(s)
  小林純, 秋山義勝, 大和雅之, 岡野光夫
- Organizer
  第55回日本人工臓器学会大会
- Data Source
  KAKENHI-PROJECT-15K01317
[Presentation] Heparin-immobilized thermoresponsive cell culture surface for sustained growth factor stimulation and cell sheet recovery2016
- Author(s)
  Jun Kobayashi, Yoshikatsu Akiyama, Masayuki Yamato, Teruo Okano
- Organizer
  3rd International Conference on Biomaterials Science in Tokyo (ICBS2016)
- Place of Presentation
  東京大学伊藤国際学術研究センター伊藤謝恩ホール（東京都文京区）
- Year and Date
  2016-11-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01317
[Presentation] Mimicking ECM nanostructure on thermoresponsive cell culture surfaces for creating functional cellular tissues2016
- Author(s)
  Jun Kobayashi
- Organizer
  2nd International Symposium on Nanoarchitectonics for Mechanobiology
- Place of Presentation
  国立研究開発法人物質・材料研究機構並木地区WPI-MANA棟オーディトリウム（茨城県つくば市）
- Year and Date
  2016-07-27
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01317
[Presentation] Switching of growth factor binding on heparin-functionalized thermoresponsive surface for hepatocyte sheet manipulation with maintenance of hepatic functions2016
- Author(s)
  Jun Kobayashi, Yoshikatsu Akiyama, Masayuki Yamato, Teruo Okano
- Organizer
  10th World Biomaterials Congress
- Place of Presentation
  モントリオール（カナダ）
- Year and Date
  2016-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K01317
[Presentation] ヘパリン修飾温度応答性表面と固定化増殖因子で作製した培養肝細胞シート2016
- Author(s)
  小林純，秋山義勝，大和雅之，岡野光夫
- Organizer
  第45回医用高分子シンポジウム
- Place of Presentation
  産業技術総合研究所臨海副都心センター別館（東京都江東区）
- Year and Date
  2016-07-25
- Data Source
  KAKENHI-PROJECT-15K01317
[Presentation] Fabrication of functional liver tissues by cell sheet-based bioassembler technologies2015
- Author(s)
  Kobayashi J, Akiyama Y, Yamato M, Okano T
- Organizer
  2015 International Symposium on Micro-NanoMechatronics and Human Science (MHS)
- Place of Presentation
  Noyori Memorial Hall, Nagoya University, Nagoya
- Year and Date
  2015-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] fficient fabrication of hepatocyte cells sheet with heparin-immobilized temperature-responsive cell culture surfaces2015
- Author(s)
  Akiyama Y, Kobayashi J, Arisaka Y, Yamato M, Okano T
- Organizer
  2015 E-MRS Spring Meeting
- Place of Presentation
  Lille, France
- Year and Date
  2015-05-12
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] Creation of functional hepatocyte sheet tissues by using heparinized thermoresponsive surfaces2015
- Author(s)
  Kobayashi J, Arisaka Y, Ohashi K, Tatsumi K, Kim K, Akiyama Y, Yamato M, Okano T
- Organizer
  2015 4th TERMIS World Congress
- Place of Presentation
  Boston, USA
- Year and Date
  2015-09-09
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] Surface design of heparin-functionalized thermoresponsive cell culture substrates for maintaining hepatic functions and harvesting cultured hepatocyte sheets2015
- Author(s)
  Kobayashi J, Arisaka Y, Ohashi K, Tatsumi K, Kim K, Akiyama Y, Yamato M, Okano T
- Organizer
  Society For Biomaterials 2015 Annual Meeting and Exposition
- Place of Presentation
  Charlotte, USA
- Year and Date
  2015-04-17
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] Heparin-functionalized thermoresponsive cell culture surfaces for creation of functional hepatic tissues2015
- Author(s)
  Kobayashi J, Arisaka Y, Ohashi K, Tatsumi K, Kim K, Akiyama Y, Yamato M, Okano T
- Organizer
  International Symposium on Frontiers in Biomedical Polymers
- Place of Presentation
  Riva del Garda, Italy
- Year and Date
  2015-07-09
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] Creation of functional liver tissues by cell-sheet technologies2015
- Author(s)
  Kobayashi J
- Organizer
  IEEE Robotics and Automaton Society (ICRA) 2015 Workshop “Hyper Bio Assembler for 3D Cellular System Innovation”
- Place of Presentation
  Seattle, USA
- Year and Date
  2015-05-30
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] 肝細胞シート機能維持のためのヘパリン機能化温度応答性細胞培養表面の設計2015
- Author(s)
  小林　純、有坂慶紀、大橋一夫、辰巳公平、金　京淑、秋山義勝、大和雅之、岡野光夫
- Organizer
  第14回日本再生医療学会総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2015-03-20
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] Surface design of heparin-functionalized temperature-responsive cell culture surfaces for maintenance of cellular functions and cell sheet recovery2014
- Author(s)
  Jun Kobayashi, Yoshinori Arisaka, Kazuo Ohashi, Kohei Tatsumi, Kyungsook Kim, Yoshikatsu Akiyama, Masayuki Yamato, and Teruo Okano
- Organizer
  The 10th SPSJ International Polymer Conference (IPC2014)
- Place of Presentation
  Epocal Tsukuba (Tsukuba)
- Year and Date
  2014-12-02
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] Regulation of affinity interaction between cells and immobilized antibodies using thermoresponsive polymer2012
- Author(s)
  Kobayashi　J
- Organizer
  9th World Biomaterials Congress,
- Place of Presentation
  Chengdu
- Year and Date
  2012-06-04
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] Regulation of affinity interaction between cells and the surface-immobilized antibody using thermoresponsive polymer2012
- Author(s)
  Kobayashi　J
- Organizer
  61st SPSJ Annual Meeting
- Place of Presentation
  Kobe
- Year and Date
  2012-05-29
- Data Source
  KAKENHI-PLANNED-23106009
[Presentation] Surface micropatterning of hydrophilic polymers by visible light irradiation2009
- Author(s)
  J.Kobayashi, K.Itoga, M.Yamato, T.Okano
- Organizer
  8th International Symposium on Frontiers in Biomedical Polymers
- Place of Presentation
  東レ総合研修センター(静岡県)
- Data Source
  KAKENHI-PROJECT-20700398
[Presentation] 改造液晶プロジェクタによる可視光投影を利用したハイドゲル薄膜のマイクロパターニング2009
- Author(s)
  小林純, 糸賀和義, 大和雅之, 岡野光夫
- Organizer
  第58回高分子討論会
- Place of Presentation
  熊本大学(熊本県)
- Data Source
  KAKENHI-PROJECT-20700398
[Presentation] 改造液晶プロジェクタによる可視光投影を利用したハイドゲル薄膜のマイクロパターニング2009
- Author(s)
  小林純, 糸賀和義, 大和雅之, 岡野光夫
- Organizer
  第58回高分子討論会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-20700398
[Presentation] Surface micropatterning by visible light irradiation with the modified liquid crystal display projector2009
- Author(s)
  J.Kobayashi, K.Itoga, M.Yamato, T.Okano
- Organizer
  第58回高分子学会年次大会
- Place of Presentation
  神戸国際会議場(兵庫県)
- Data Source
  KAKENHI-PROJECT-20700398
[Presentation] Observation of cell detachment behavior from temperature responsive polymer grafted surfaces using total internal reflection fluorescence microscopy2009
- Author(s)
  Kazuhiro Fukumori, Yoshikatsu Akiyama, Yoshikazu Kumashiro, Jun Kobayashi, Masayuki Yamato, Kiyotaka Sakai, Teruo Okano.
- Organizer
  8th International Symposium on Frontiers in Biomedical Polymers
- Place of Presentation
  Mishima
- Data Source
  KAKENHI-PROJECT-17076014
[Presentation] 原子間力顕微鏡を用いた温度応答性高分子薄膜の物性評価2009
- Author(s)
  福守一浩, 熊代善一, 秋山義勝, 小林純, 大和雅之, 酒井清孝, 岡野光夫
- Organizer
  第58回高分子学会年次大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17076014
[Presentation] Development of the maskless photolithography device with an LCD-projector for fabrication of micropatterned surfaces2009
- Author(s)
  K.Itoga, J.Kobayashi, M.Yamato, T.Okano
- Organizer
  2009 International Symposium on Micro-NanoMechatronics and Human Science
- Place of Presentation
  名古屋
- Year and Date
  2009-11-09
- Data Source
  KAKENHI-PROJECT-17076014
[Presentation] バイオイメージングを指向した温度応答性ガラス表面の作製2009
- Author(s)
  福守一浩, 秋山義勝, 小林純, 大和雅之, 酒井清孝, 岡野光夫
- Organizer
  日本医工学治療学会第25回学術大会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-17076014
[Presentation] 温度応答性高分子薄膜ゲルの膨潤、収縮の物性評価2009
- Author(s)
  福守一浩, 秋山義勝, 熊代善一, 小林純, 大和雅之, 酒井清孝, 岡野光夫.
- Organizer
  第58回高分子討論会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-17076014
[Presentation] Surface micropatterning by visible light irradiation with the modified liquid crystal display projector2009
- Author(s)
  Jun Kobayashi, Kazuyoshi Itoga, Masayuki Yamato, Teruo Okano
- Organizer
  第58回高分子学会年次大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20700398
[Presentation] 温度応答性超薄膜ゲル表面の膜厚依存による細胞接着性の変化2009
- Author(s)
  福守一浩, 熊代善一, 秋山義勝, 小林純, 大和雅之, 酒井清孝, 岡野光夫
- Organizer
  第3回バイオ・ナノテクフォーラムシンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-17076014
[Presentation] Surface micropatterning of hydrophilic polymers by visible light irradiation2009
- Author(s)
  Jun Kobayashi, Kazuyoshi Itoga, Masayuki Yamato, Teruo Okano
- Organizer
  8th International Symposium on Frontiers in Biomedical Polymers
- Place of Presentation
  三島
- Data Source
  KAKENHI-PROJECT-20700398
[Presentation] 温度応答性表面の細胞接着特性と表面近傍に特化した細胞剥離挙動への応用2008
- Author(s)
  福守一浩, 秋山義勝, 小林純, 大和雅之, 酒井清孝, 岡野光夫.
- Organizer
  第57回高分子討論会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-17076014
[Presentation] 温度応答性ガラス表面の作製とバイオイメージングへの応用2008
- Author(s)
  福守一浩, 秋山義勝, 小林純, 大和雅之, 酒井清孝, 岡野光夫
- Organizer
  第72回化学工学会秋季大会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-17076014

1. AKIYAMA Yoshikatsu (20349640)

# of Collaborated Projects: 4 results

# of Collaborated Products: 36 results
2. TAKAHAHI Hironobu (00710039)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. YAMATO Masayuki (40267117)

# of Collaborated Projects: 2 results

# of Collaborated Products: 29 results
4. NAKAYAMA Masamichi (00338980)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. NAGASE Kenichi (10439838)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. HIDA Akira (30361778)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. SHIMIZU Tatsuya (40318100)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SHIMIZU Tatsuya (70468867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 菊池明彦 (40266820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. 増田信奈子 (30342851)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 辰巳公平 (70555432)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 山岡哲二 (50243126)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 松浦勝久 (70433993)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 梅津信二郎 (70373032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 江藤浩之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KOBAYASHI Jun 小林 純

Research Projects

Research Products

Co-Researchers

Understanding the regulatory mechanisms of cardiomyocyte alignment control and maintenance

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Design of extracellular matrices for mRNA delivery to cell sheet tissuesPrincipal Investigator

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Induction of vasculogenesis and angiogenesis in three-dimensional tissues by using protein expressions with mRNA deliveryPrincipal Investigator

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Design of a next generation thermoresponsive culture system for creating functional cultured hepatic sheet tissuesPrincipal Investigator

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Development of microfluidic device on antibody immobilized-thermoresponsive surfaces for cell sortingPrincipal Investigator

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Fabrication of structually comlicated soft tissue such as liver-tissues and understanding its biological function of teh fabricated liver-tissue

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Application of microfluidics for cell sheet-based tissue engineeringPrincipal Investigator

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Research of cell detachment behavior from nano-biomaterial surfaces

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三次元マイクロ流路チップを高速プロトタイプするマスクレス光造形技術Principal Investigator

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[Book] Hyper Bio Assembler for 3D Cellular Systems2015

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[Book] Biomaterials Surface Science2013

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[Book] 先端医療シリーズ37 「人工臓器・再生医療の最前線」 第18章 再生医療の基盤技術 4.微細加工技術, p.321-3242005

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[Journal Article] Preservation of heparin-binding EGF-like growth factor activity on heparin-modified poly(N-isopropylacrylamide)-grafted surfaces2021

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Journal Title

DOI

Data Source

[Journal Article] On-off affinity binding modulation on thermoresponsive polymer-grafted surfaces for capture and release of proteins and cells2017

Author(s)

KOBAYASHI Jun 小林純

[Book] 先端医療シリーズ37 「人工臓器・再生医療の最前線」第18章再生医療の基盤技術 4.微細加工技術, p.321-3242005