Ohtsuka Isao 大塚功

… Alternative Names

大塚功オオツカイサオ

OHTSUKA Isao 大塚功

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Researcher Number	20389589
Other IDs
Affiliation (Current)	2025: 横浜薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2019: 九州保健福祉大学, 薬学部, 教授 2013: 九州保健福祉大学, 薬学部, 准教授 2009 – 2012: 九州保健福祉大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Chemical pharmacy Except Principal Investigator Environmental and hygienic pharmacy / Chemical biology / Chemical biology
Keywords	Principal Investigator 光反応基 / 光アフィニティーラベル法 / 糖鎖-レクチン認識 / シアリルルイスX / ケミカルバイオロジー / 有機化学 / 糖鎖合成 Except Principal Investigator バイオテクノロジー / 分析化学 / プロテオーム … More / 光反応 / 環境衛生学 / アレルギー・ぜんそく / アレルギー / 炎症性サイトカイン / Aspergillus fumigatus / 炎症性メディエーター / 室内環境 / 免疫 / 喘息 / 真菌 / 糖脂質 / プロテーム / 質量分析 / ゲルシフトアッセイ / DNA結合タンパク質 / コンフォメーション病 / 薬学 / 糖鎖 / 神経科学 / アミロイド Less

Identification and mechanism elucidation of indoor environmental fungal glycosphingolipids involved in onset and exacerbation of asthma
- Principal Investigator
  
  Ohkawara Susumu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental and hygienic pharmacy
- Research Institution
  Yokohama College of Pharmacy
Elucidation of sialyl LeX-serectin interaction by photoaffinty labellingPrincipal Investigator
- Principal Investigator
  
  OHTSUKA Isao
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Kyushu University of Health and Welfare
Development of photochemical cloning for DNA-binding proteins
- Principal Investigator
  
  SADAKANE Yutaka
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Suzuka University of Medical Science
Development of the photochemical panning adapted to low affinity ligands and analysis of neural carbohydrates' functions
- Principal Investigator
  
  SADAKANE Yutaka
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical biology
- Research Institution
  Kyushu University of Health and Welfare

All 2020 2014 2013 2012 2011 2010 2009 2008

All Journal Article Presentation

[Journal Article] Chemical Synthesis of Sialyl Glycosides for Elucidation of Biological Phenomena2014
- Author(s)
  Ohtsuka, Isao., Atsumi, Toshiyuki., Kakiuchi, Nobuko.
- Journal Title
  
  J. KUHW.
  
  Volume: 15 Pages: 73-79
- NAID
  110009799851
- Data Source
  KAKENHI-PROJECT-24790033
[Journal Article] The development of new molecular tools containing a chemically synthesized carbohydrate ligand for the elucidation of carbohydrate roles via photoaffinity labeling : Carbohydrate-protein interactions are affected by the structures of the glycosidic bonds and the reducing- end sugar2014
- Author(s)
  Ohtsuka, Isao., Sadakane, Yutaka., Hada, Noriyasu., Higuchi, Mari., Atsumi, Toshiyuki., Kakiuchi, Nobuko.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: (submitted)
- Data Source
  KAKENHI-PROJECT-24790033
[Journal Article] 41) Chemical Synthesis of Sialyl Glycosides for Elucidation of Biological Phenomena.2014
- Author(s)
  Ohtsuka, Isao. *, Atsumi, Toshiyuki., Kakiuchi, Nobuko.
- Journal Title
  
  J.KUHW
  
  Volume: 15 Pages: 73-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790033
[Journal Article] Synthesis of a New Glycosphingolipid from the Marine Ascidian Microcosmus sulcatus using a One-Pot Glycosylation Strategy2013
- Author(s)
  Ohtsuka I
- Journal Title
  
  Tetrahedron
  
  Volume: 69 Issue: 5 Pages: 1470-1475
- DOI
  10.1016/j.tet.2012.12.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590116, KAKENHI-PROJECT-24790033, KAKENHI-PROJECT-25460131
[Journal Article] Establishment of Synthesis Method of Molecular Probe Containing Carbohydrate Ligand and Photoreactive Group for Elucidation of Carbohydrate?Lectin Interactions by Glycosyl Trichloroacetoimidate Strategy2013
- Author(s)
  Ohtsuka, Isao., Sadakane, Yutaka., Atsumi, Toshiyuki., Kakiuchi, Nobuko.
- Journal Title
  
  J. KUHW
  
  Volume: 14 Pages: 165-171
- NAID
  110009596008
- Data Source
  KAKENHI-PROJECT-24790033
[Journal Article] Establishment of Synthesis Method of Molecular Probe Containing Carbohydrate Ligand and Photoreactive Group for Elucidation of Carbohydrate – Lectin Interactions by Glycosyl Trichloroacetoimidate Strategy.2013
- Author(s)
  Ohtsuka, Isao. *, Sadakane, Yutaka., Atsumi, Toshiyuki., Kakiuchi, Nobuko.
- Journal Title
  
  jounal of KUHW
  
  Volume: 14 Pages: 165-171
- NAID
  110009596008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790033
[Journal Article] Effect of the binding affinity of carbohydrates and proteins by the structural difference of the reducing terminal of sugar using photoaffinity labeling.2011
- Author(s)
  Isao Ohtsuka, Yutaka Sadakane, Mari Higuchi, Noriyasu Hada, Junko Hada, Nobuko Kakiuchi, Akiyo Sakushima
- Journal Title
  
  Bioorg Med.Chem. 19
  
  Pages: 894-899
- Data Source
  KAKENHI-PROJECT-20611021
[Journal Article] The effect of the structural differences in the reducing terminus of sugars on the binding affinity of carbohydrates and proteins analyzed using photoaffinity labeling.2011
- Author(s)
  Isao Ohtsuka, Yutaka Sadakane, Mari Higuchi, Noriyasu Hada, Junko Hada, Nobuko Kakiuchi, Akiyo Sakushima
- Journal Title
  
  Bioorg Med. Chem.
  
  Volume: 19 Issue: 2 Pages: 894-899
- DOI
  10.1016/j.bmc.2010.11.067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23510286
[Journal Article] The effect of the structural differences in the reducing terminus of sugars on the binding affinity of carbohydrates and proteins analyzed using photoaffinity labeling2011
- Author(s)
  I. Ohtsuka, Y. Sadakane, M. Higuchi, N. Hada, J. Hada, N. Kakiuchi, A. Sakushima
- Journal Title
  
  Bioorg Med. Chem.
  
  Volume: 19 Pages: 894-899
- Data Source
  KAKENHI-PROJECT-23510286
[Journal Article] Membrane incorporation, channel formation, and disruption of calcium homeostasis by Alzheimer's beta-amyloid protein.2011
- Author(s)
  Masahiro Kawahara, Isao Ohtsuka, Shoko Yokoyama, Midori Kato-Negishi, Yutaka Sadakane
- Journal Title
  
  International Journal of Alzheimer's Disease. 2011,Article ID 304583 17
- Data Source
  KAKENHI-PROJECT-20611021
[Journal Article] Effect of the binding affinity of carbohydrates and proteins by the structural difference of the reducing terminal of sugar using photoaffinity labeling2011
- Author(s)
  Ohtsuka I.
- Journal Title
  
  Bioorg Med.Chem.
  
  Volume: 19 Pages: 894-899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] Hirsutella rhossiliensis糖脂質合成類縁体によるTHP-1細胞のLPS誘導性炎症メディエーター産生の抑制2020
- Author(s)
  門松隆夫，大河原　晋，礒部　隆史，神野　透人,香川（田中）聡子，金谷　貴行，羽田　紀康，大塚　功，埴岡　伸光
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17K08395
[Presentation] 光反応性糖鎖ミメティックペプチドの合成とレクチン解析への応用2014
- Author(s)
  定金豊,松下秀峰,山路充宏,大塚功
- Organizer
  日本薬学会第133年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24790033
[Presentation] 光反応性糖鎖ミメティックペプチドの合成とレクチン解析への応用2014
- Author(s)
  定金豊, 松下秀峰, 山路充宏, 大塚功
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-23510286
[Presentation] 1) 光反応性糖鎖ミメティックペプチドの合成とレクチン解析への応用2014
- Author(s)
  定金豊, 松下秀峰, 山路充宏, 大塚功
- Organizer
  日本薬学会第133年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-24790033
[Presentation] 5) 光アフィニティーラベル法による新規分子ツールの開発 -糖鎖結合様式が認識に及ぼす影響を検証-2013
- Author(s)
  大塚功, 定金豊, 羽田紀康, 渥美聡孝, 垣内信子
- Organizer
  第30回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-24790033
[Presentation] 光アフィニティーラベル法による新規分子ツールの開発-糖鎖結合様式が認識に及ぼす影響を検証-2013
- Author(s)
  大塚功,定金豊,羽田紀康,渥美聡孝,垣内信子
- Organizer
  第30回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-24790033
[Presentation] Synthesis of new molecular tools for elucidation of carbohydrates roles by photoaffinity labeling: Carbohydrate – Carbohydrate-protein interactions are affected by different of glycosidic formations.2012
- Author(s)
  I. Ohtsuka; Y. Sadakane; N. Hada, M. Higuchi; N. Kakiuchi
- Organizer
  International Carbohydrate Symposium
- Place of Presentation
  Spain
- Data Source
  KAKENHI-PROJECT-23510286
[Presentation] 光反応性糖鎖リガンドを用いた結合解析法の効率化2012
- Author(s)
  定金豊, 山路充宏, 大塚功
- Organizer
  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2012
- Place of Presentation
  岐阜
- Year and Date
  2012-11-18
- Data Source
  KAKENHI-PROJECT-23510286
[Presentation] Synthesis of new molecular tools for elucidation of carbohydrates roles by photoaffinity labeling: Carbohydrate - Carbohydrate-protein interactions are affected by different of glycosidic formations2012
- Author(s)
  I. Ohtsuka, Y. Sadakane, N. Hada, M. Higuchi, N. Kakiuchi
- Organizer
  International Carbohydrate Symposium
- Place of Presentation
  Spain
- Data Source
  KAKENHI-PROJECT-23510286
[Presentation] 還元末端が閉環した構造をもつ光反応性糖鎖リガンドの合成と結合解析法の確立2012
- Author(s)
  定金豊, 大塚功, 山路充宏, 畑中保丸
- Organizer
  第34回日本光医学・光生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-23510286
[Presentation] Synthesis of New Molecular Tools for Elucidation of Carbohydrates Roles by Photoaffinity Labeling ~Carbohydrate?Protein Interactions are Affected by Different of Glycosidic Formations and Conformation of Reducing End Sugar~2012
- Author(s)
  Ohtsuka, Isao., Sadakane, Yutaka., Hada, Noriyasu., Hada, Junko., Kakiuchi, Nobuko.
- Organizer
  26th International Carbohydrate Symposium 2012 (ICS 2012)
- Place of Presentation
  Madrid, Spain
- Data Source
  KAKENHI-PROJECT-24790033
[Presentation] Synthesis of New Molecular Tools for Elucidation of Carbohydrates Roles by Photoaffinity Labeling ~Carbohydrate – Protein Interactions are Affected by Different of Glycosidic Formations and Conformation of Reducing End Sugar~2012
- Author(s)
  Ohtsuka, Isao., Sadakane, Yutaka., Hada, Noriyasu., Hada, Junko., Kakiuchi, Nobuko.
- Organizer
  26th International Carbohydrate Symposium 2012 (ICS 2012)
- Place of Presentation
  Madrid
- Data Source
  KAKENHI-PROJECT-24790033
[Presentation] 光アフィニティーラベル法による新規分子ツールの開発～糖鎖結合様式が認識に及ぼす影響を検証～2012
- Author(s)
  大塚功, 定金豊, 羽田紀康, 羽田純子, 新垣達司, 樋口真里, 垣内信子
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23510286
[Presentation] 糖鎖機能の効率的化未明を目指した光反応性糖鎖リガンドの製作2010
- Author(s)
  定金豊,大塚功,川原正博,畑中保丸
- Organizer
  第32回日本光医学・光生物学会
- Place of Presentation
  東京
- Year and Date
  2010-07-30
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] Synthesis of new molecular tools for elucidation of carbohydrates roles by photo affinity labeling : Carbohydrate-protein interactions are affected by different of glycosidic formations.2010
- Author(s)
  Ohtsuka I
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  Hawaii
- Year and Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 光アフィニティーラベル法による糖鎖機能解明を目指した新規分子ツールの創製2010
- Author(s)
  大塚功
- Organizer
  第130年会日本薬学会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] Effects of zinc and copper on conformational changes and neurotoxicity of prion fragment peptide (PrP106-126)2010
- Author(s)
  小山裕也、定金豊、大塚功、川原正博
- Organizer
  第20回金属の関与する生体関連反応シンポジウム(SRM2010)
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 光アフィニティーラベル法による糖鎖機能解明を目指した新規分子ツールの創製2010
- Author(s)
  大塚功,定金豊,樋口真理,佐久島明世
- Organizer
  日本薬学会第130回年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-30
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] Synthesis of new molecular tools for elucidation of carbohydrates roles by photoaffinity labeling : Carbohydrate-protein interactions are affected by different of glycosidic formations.2010
- Author(s)
  I.Ohtsuka ; Y.Sadakane ; M.Higuchi ; N.Kakiuchi ; A.Sakushima
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  Hawaii
- Year and Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 光アフィニティーラベル法による糖鎖機能解明を目指した新規分子ツールの開発2010
- Author(s)
  大塚功,定金豊,樋口真里,垣内信子
- Organizer
  第27回日本薬学会九州支部大会
- Place of Presentation
  長崎
- Year and Date
  2010-12-11
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 微量元素の神経毒性と老年性認知症の発症メカニズム2009
- Author(s)
  川原正博,永田哲也,大塚功,木葉敬子,定金豊,横山祥子
- Organizer
  日本薬学会シンポジウム「金属の関与する生命科学(II)トキシコメタロミクス研究の新展開～最新分析法開発から創薬、診断、治療へのアプローチ」
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] プリオン蛋白断片ペプチドPrP106-126のコンフォーメーションの違いによる細胞膜中における糖脂質認識能について-原子間力顕微法による直接観察2009
- Author(s)
  大塚功,永田哲也,木葉敬子,定金豊,川原正博,横山祥子
- Organizer
  日本薬学会第129回年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] 光反応性生体高分子リガンドの開発と光化学的スクリーニング法への応用2009
- Author(s)
  定金豊,大塚功,木葉敬子,畑中保丸
- Organizer
  第31回日本光医学・光生物学会
- Place of Presentation
  大阪
- Year and Date
  2009-07-23
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] プリオン断片蛋白PrP106-126のコンフォーメーションの違いによるGM1への認識能の変化-原子間力顕微法による直接観察2008
- Author(s)
  大塚功、永田哲也、木葉敬子、定金豊、川原正博、横山祥子
- Organizer
  第25回日本薬学会九州支部大会
- Place of Presentation
  (延岡)
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] YOKOYAMA Effects of trace elements on prion-induced neurotoxicity of primary cultured hippocampal neurons2008
- Author(s)
  M.KAWAHARA, T.NAGATA1, OHTSUKA, K.KONOHA, Y.SADAKANE, S
- Organizer
  Neuroscience 2008
- Place of Presentation
  Washington D.C., U.S.A.
- Year and Date
  2008-11-19
- Data Source
  KAKENHI-PROJECT-20611021
[Presentation] プジオン断片蛋白PrP106-126のコンフォーメーションの違いによるGM1への認識能の変化-原子間力顕微法による直接観察2008
- Author(s)
  大塚功, 他
- Organizer
  第25回日本薬学会九州支部大会
- Place of Presentation
  宮崎
- Year and Date
  2008-12-06
- Data Source
  KAKENHI-PROJECT-20611021

1. SADAKANE Yutaka (60293304)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
2. KAWAHARA Masahiro (40224828)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
3. KONOHA Keiko (00369175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. Ohkawara Susumu (20409387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Ohtsuka Isao 大塚 功

大塚 功 オオツカ イサオ

OHTSUKA Isao 大塚 功

Research Projects

Research Products

Co-Researchers

Identification and mechanism elucidation of indoor environmental fungal glycosphingolipids involved in onset and exacerbation of asthma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of sialyl LeX-serectin interaction by photoaffinty labellingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of photochemical cloning for DNA-binding proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of the photochemical panning adapted to low affinity ligands and analysis of neural carbohydrates' functions

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Chemical Synthesis of Sialyl Glycosides for Elucidation of Biological Phenomena2014

Author(s)

Journal Title

NAID

Data Source

Author(s)

Journal Title

Data Source

[Journal Article] 41) Chemical Synthesis of Sialyl Glycosides for Elucidation of Biological Phenomena.2014

Author(s)

Journal Title

Data Source

[Journal Article] Synthesis of a New Glycosphingolipid from the Marine Ascidian Microcosmus sulcatus using a One-Pot Glycosylation Strategy2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Establishment of Synthesis Method of Molecular Probe Containing Carbohydrate Ligand and Photoreactive Group for Elucidation of Carbohydrate?Lectin Interactions by Glycosyl Trichloroacetoimidate Strategy2013

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Establishment of Synthesis Method of Molecular Probe Containing Carbohydrate Ligand and Photoreactive Group for Elucidation of Carbohydrate – Lectin Interactions by Glycosyl Trichloroacetoimidate Strategy.2013

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Effect of the binding affinity of carbohydrates and proteins by the structural difference of the reducing terminal of sugar using photoaffinity labeling.2011

Author(s)

Journal Title

Data Source

[Journal Article] The effect of the structural differences in the reducing terminus of sugars on the binding affinity of carbohydrates and proteins analyzed using photoaffinity labeling.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The effect of the structural differences in the reducing terminus of sugars on the binding affinity of carbohydrates and proteins analyzed using photoaffinity labeling2011

Author(s)

Journal Title

Data Source

[Journal Article] Membrane incorporation, channel formation, and disruption of calcium homeostasis by Alzheimer's beta-amyloid protein.2011

Author(s)

Journal Title

Data Source

[Journal Article] Effect of the binding affinity of carbohydrates and proteins by the structural difference of the reducing terminal of sugar using photoaffinity labeling2011

Author(s)

Journal Title

Data Source

[Presentation] Hirsutella rhossiliensis糖脂質合成類縁体によるTHP-1細胞のLPS誘導性炎症メディエーター産生の抑制2020

Author(s)

Ohtsuka Isao 大塚功

大塚功オオツカイサオ

OHTSUKA Isao 大塚功