TAKAHASHI TOSHIO 高橋俊雄

… Alternative Names

高橋俊雄タカハシトシオ

TAKAHASHI Toshio 高橋俊雄

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Researcher Number	20390792
Other IDs
Affiliation (Current)	2025: 公益財団法人サントリー生命科学財団, 生物有機科学研究所・統合生体分子機能研究部, 主幹研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 公益財団法人サントリー生命科学財団, 生物有機科学研究所・統合生体分子機能研究部, 主幹研究員 2018 – 2022: 公益財団法人サントリー生命科学財団, 生物有機科学研究所・統合生体分子機能研究部, 主席研究員 2016 – 2017: 公益財団法人サントリー生命科学財団, 生物有機科学研究所・統合生体分子機能研究部, 研究員 2015: 公益財団法人サントリー, 生物有機科学研究所, 研究員 2014 – 2015: 公益財団法人サントリー生命科学財団, その他部局等, 研究員 … More 2007: Suntory Institute for Bioorganic Research, 研究員 2004 – 2006: (財)サントリー生物有機科学研究所, 研究員 2005: Suntory Institute for Bioorganic Research, Researcher, 研究員 2005: 財団法人サントリー生物有機科学研究所, 研究員 Less
Review Section/Research Field	Principal Investigator Animal physiology/Animal behavior / Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related Except Principal Investigator Morphology/Structure / Biomolecular chemistry
Keywords	Principal Investigator 生体分子 / 腸幹細胞 / オルガノイド / 非神経性アセチルコリン / 発生・分化 / 組織形成 / 増殖 / 分化 / シグナル伝達経路 / 生理学 … More / シグナル伝達 / 細胞・組織 / 分化・増殖・維持 / アセチルコリン受容体 / アセチルコリン / 腸上皮幹細胞 / ニコチン性アセチルコリン受容体 / 腸オルガノイド / 腸上皮 / コリン作動系 / 進化 / 生理活性 … More Except Principal Investigator GnIH / caco2細胞 / トランスポーター / 小腸吸収 / 鉄代謝 / 小腸 / キレート化合物 / 植物性食物 / ニコチアナミン / 鉄 / immunohistochemistry / expression and distribution / vasopressin family / oxytocin / G-protein-coupled receptor / Gonadotropin-releasing hormone / Octopus vulgaris / in situ hybridization / アフリカツメガエル卵母細胞発現 / クローニング / 性腺刺激ホルモン放出ホルモン / バソプレシンファミリー / Octpus vulgalis / 免疫染色 / 発現分布 / バソプレシン / オキシトシン / G-タンパク共役型受容体 / 生殖腺刺激ホルモン放出ホルモン / Octopus vulgalis / reproduction / prolactin / gonadotropin / pituitary hormones / GnIH receptor / GnIH homologOus peptides / hypothalamic neurohormones / 新規視床下部ペプチド受容体 / 成長ホルモン放出促進ペプチド / ゴナドトロピン放出抑制ホルモン / 成長ホルモン / ゴナドトロピン / 新規視床下部ペプチド / メラトニン / 視床下部ニューロン / 生殖腺刺激ホルモン放出抑制ホルモン(GnIH) / 生殖 / プロラクチン / 生殖腺刺激ホルモン / 脳下垂体ホルモン / GnIH受容体 / GnIH同属ペプチド / 新規視床下部ホルモン Less

Elucidation of acetylcholine signaling in aid of intestinal stem cell stemnessPrincipal Investigator
- Principal Investigator
  
  高橋俊雄
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
- Research Institution
  Suntory Foundation for Life Sciences
Elucidation of regulatory mechanism of intestinal stem cell proliferation and differentiation via non-neuronal acetylcholine receptorsPrincipal Investigator
- Principal Investigator
  
  Toshio Takahashi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
- Research Institution
  Suntory Foundation for Life Sciences
Elucidation of regulatory mechanism of non-neuronal acetylcholine as an endogenous regulator of proliferation, differentiation, and maintenance of intestinal stem cellsPrincipal Investigator
- Principal Investigator
  
  Takahashi Toshio
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Animal physiology/Animal behavior
- Research Institution
  Suntory Foundation for Life Sciences
Elucidation of a novel physiological function of acetylcholine in gut epitheliumPrincipal Investigator
- Principal Investigator
  
  Takahashi Toshio
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Animal physiology/Animal behavior
- Research Institution
  Suntory Foundation for Life Sciences
Effects of iron chelator nicotianamine from plant food on iron absorption in intestine
- Principal Investigator
  
  Murata Yoshiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  Suntory Foundation for Life Sciences
ヒドラの生体制御に関与するペプチド性シグナル分子とその受容体の網羅的解析Principal Investigator
- Principal Investigator
  
  高橋俊雄
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Animal physiology/Animal behavior
- Research Institution
  Suntory Institute for Bioorganic Research
Expression and distribution of novel peptidehormones in memory and learning system of cephalopod brain
- Principal Investigator
  
  MINAKATA Hiroyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphology/Structure
- Research Institution
  Suntory Institute for Bioorganic Research
Regulation of the synthesis and release of pituitary hormones by novel hypothalamic neurohormones
- Principal Investigator
  
  TSUTSUI Kazuyoshi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Morphology/Structure
- Research Institution
  Hiroshima University

[Book] Medical Science Digest2023
- Author(s)
  高橋俊雄
- Total Pages
  4
- Publisher
  ニューサイエンス社
- Data Source
  KAKENHI-PROJECT-23K05862
[Book] BIO Clinica2021
- Author(s)
  高橋俊雄
- Total Pages
  4
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-20K06751
[Book] Advances Invertebrate (Neuro)Endocrinology2020
- Author(s)
  Toshio Takahashi
- Total Pages
  406
- Publisher
  Apple Academic Press, USA
- ISBN
  9781771888936
- Data Source
  KAKENHI-PROJECT-20K06751
[Book] Advances Invertebrate (Neuro)Endocrinology2020
- Author(s)
  Takahashi T.
- Total Pages
  24
- Publisher
  Apple Academic Press, USA
- Data Source
  KAKENHI-PROJECT-17K07495
[Book] Advances Invertebrate (Neuro)Endocrinology2019
- Author(s)
  Toshio Takahashi
- Publisher
  APPLE ACADEMIC PRESS
- Data Source
  KAKENHI-PROJECT-17K07495
[Book] 質量分析でアセチルコリンを”可視化する”技2017
- Author(s)
  高橋俊雄
- Total Pages
  2
- Publisher
  比較内分泌学
- Data Source
  KAKENHI-PROJECT-17K07495
[Book] 多段階質量分析イメージングによる腸上皮組織中のアセチルコリン分布とその役割2016
- Author(s)
  高橋俊雄
- Total Pages
  2
- Publisher
  比較内分泌学
- Data Source
  KAKENHI-PROJECT-26440184
[Book] 「CompBiol 2015 合同シンポジウム」”ホストオミクス時代における画像解析の最前線”顛末記2016
- Author(s)
  高橋俊雄
- Total Pages
  3
- Publisher
  比較生理生化学
- Data Source
  KAKENHI-PROJECT-26440184
[Book] Hym-176 in Handbook of Hormone Handbook2015
- Author(s)
  Toshio Takahashi
- Total Pages
  2
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26440184
[Book] Handbook of Hormones2015
- Author(s)
  Takahashi T
- Total Pages
  12
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26440184
[Book] Hym-301 in Handbook of Hormone Handbook2015
- Author(s)
  Toshio takahashi
- Total Pages
  2
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26440184
[Book] LF Peptides in Handbook of Hormone Handbook2015
- Author(s)
  Toshio Takahashi
- Total Pages
  1
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26440184
[Book] 研究者が教える動物実験2015
- Author(s)
  森下、高橋
- Total Pages
  5
- Publisher
  日本比較生理生化学会編
- Data Source
  KAKENHI-PROJECT-26440184
[Book] 「研究者が教える動物実験」　生理活性ペプチドを“見つける”技2015
- Author(s)
  森下文浩、高橋俊雄
- Total Pages
  4
- Publisher
  日本比較生理生化学会編
- Data Source
  KAKENHI-PROJECT-26440184
[Book] GLWamide in Handbook of Hormone Handbook2015
- Author(s)
  Toshio Takahashi
- Total Pages
  2
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26440184
[Book] Hym-323 in Handbook of Hormone Handbook2015
- Author(s)
  Toshio Takahashi
- Total Pages
  2
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26440184
[Book] Head Activator in Handbook of Hormone Handbook2015
- Author(s)
  Toshio Takahashi
- Total Pages
  2
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-26440184
[Book] New perspectives on neuropeptides in Hydra2006
- Author(s)
  Toshio Takahashi
- Publisher
  Transworld Research Network
- Data Source
  KAKENHI-PROJECT-18770054
[Book] New perspectives on neuropeptides in Hydra.(H. Satake (ed))2006
- Author(s)
  T.Takahashi et al.
- Total Pages
  15
- Publisher
  In : Invertebrate Neuropeptides and Hormones : Basic Knowledge and Recent Advances, Transworld Research Network, India
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15207007
[Journal Article] Characterization of a novel species-specific 51-amino acid peptide, PEP51, as a caspase-3/7 activator in ovarian follicles of the ascidian, Ciona intestinalis Type A2023
- Author(s)
  Tsubasa Sakai, Tatsuya Yamamoto, Takehiro Watanabe, Akiko Hozumi, Akira Shiraishi, Tomohiro Osugi, Shin Matsubara, Tsuyoshi Kawada, Yasunori Sasakura, Toshio Takahashi, Honoo Satake
- Journal Title
  
  Front. Endocrinol.
  
  Volume: 14 Pages: 1-13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K05862
[Journal Article] Method for Two-Dimensional Epithelial Monolayer Formation Derived from Mouse Three-Dimensional Small Intestinal Organoids2023
- Author(s)
  Takase Yuta、Takahashi Toshio
- Journal Title
  
  Epithelial Cell Culture
  
  Volume: - Pages: 73-84
- DOI
  10.1007/978-1-0716-3609-1_7
- ISBN
  9781071636084, 9781071636091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06238, KAKENHI-PROJECT-23K05862
[Journal Article] The 3D Culturing of Organoids from Murine Intestinal Crypts and a Single Stem Cell for Organoid Research2023
- Author(s)
  Takase Yuta、Fujishima Kazuto、Takahashi Toshio
- Journal Title
  
  Journal of Visualized Experiments
  
  Volume: - Issue: 194 Pages: 1-10
- DOI
  10.3791/65219
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06238, KAKENHI-PROJECT-20K06751, KAKENHI-PROJECT-19K16140, KAKENHI-PROJECT-23K05862
[Journal Article] Multiple roles for cholinergic signaling from the perspective of stem cell function2021
- Author(s)
  Toshio Takahashi
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 22 Issue: 2 Pages: 1-16
- DOI
  10.3390/ijms22020666
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06751
[Journal Article] 非神経細胞型アセチルコリン受容体を介した腸幹細胞の維持機構の解明2021
- Author(s)
  高橋俊雄
- Journal Title
  
  BIO Clinica
  
  Volume: 36 Pages: 94-97
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06751
[Journal Article] Modeling intestinal stem cell function with organoids2021
- Author(s)
  Toshio Takahashi, Kazuo Fujishima, and Mineko Kengaku
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 22 Issue: 20 Pages: 1-14
- DOI
  10.3390/ijms222010912
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06751, KAKENHI-PROJECT-18KK0212
[Journal Article] Muscarinic receptor M3 contributes to intestinal stem cell maintenance via EphB/ephrin-B signaling2021
- Author(s)
  Takahashi Toshio、Shiraishi Akira、Murata Jun、Matsubara Shin、Nakaoka Satsuki、Kirimoto Shinji、Osawa Masatake
- Journal Title
  
  Life Science Alliance
  
  Volume: 4 Issue: 9 Pages: 1-17
- DOI
  10.26508/lsa.202000962
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08770, KAKENHI-PROJECT-20K06751
[Journal Article] Distribution and physiological effect of enterin neuropeptides in the olfactory centers of the terrestrial slug Limax.2020
- Author(s)
  *Matsuo R, Kobayashi S, Furuta A, Osugi T, Takahashi T, Satake H, and Matsuo Y
- Journal Title
  
  J Comp Physiol A
  
  Volume: in press Issue: 3 Pages: 401-418
- DOI
  10.1007/s00359-020-01400-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06772, KAKENHI-PROJECT-19K06752, KAKENHI-PROJECT-20K06750, KAKENHI-PROJECT-20K06751
[Journal Article] Short-chain fatty acids bind to apoptosis-associated speck-like protein to activate inflammasome complex to prevent Salmonella infection2020
- Author(s)
  Tsugawa Hitoshi、Kabe Yasuaki、Kanai Ayaka、Sugiura Yuki、Hida Shigeaki、Taniguchi Shun’ichiro、Takahashi Toshio、Matsui Hidenori、Yasukawa Zenta、Itou Hiroyuki、Takubo Keiyo、Suzuki Hidekazu、Honda Kenya、Handa Hiroshi、Suematsu Makoto
- Journal Title
  
  PLOS Biology
  
  Volume: 18 Issue: 9 Pages: 3000813-3000813
- DOI
  10.1371/journal.pbio.3000813
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07068, KAKENHI-PROJECT-20K06751, KAKENHI-PROJECT-20K07017, KAKENHI-PROJECT-18H02845, KAKENHI-PROJECT-19H03474, KAKENHI-PROJECT-20H03667, KAKENHI-PROJECT-18K06781, KAKENHI-PROJECT-18K06921
[Journal Article] Roles of nAChR and Wnt signaling in intestinal stem cell function and inflammation2020
- Author(s)
  Takahashi T.
- Journal Title
  
  Int. Immunopharmacol.
  
  Volume: 81 Pages: 1-5
- DOI
  10.1016/j.intimp.2020.106260
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07495, KAKENHI-PROJECT-20K06751
[Journal Article] Mechanism of gamete shedding in starfish: Involvement of acetylcholine in extracellular Ca2+-dependent contraction of gonadal walls2020
- Author(s)
  Mita Masatoshi、Osugi Tomohiro、Takahashi Toshio、Watanabe Takehiro、Satake Honoo
- Journal Title
  
  General and Comparative Endocrinology
  
  Volume: 290 Pages: 113401-113401
- DOI
  10.1016/j.ygcen.2020.113401
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K06747, KAKENHI-PROJECT-19K06752, KAKENHI-PROJECT-20K06751
[Journal Article] ヒトデの配偶子放出のメカニズム：ヒトデの放卵・放精はアセチルコリンによるCa2+-influxにより誘起される2020
- Author(s)
  三田雅敏、大杉知宏、高橋俊雄、渡辺健宏、佐竹炎
- Journal Title
  
  Comparative Endocrinology
  
  Volume: 46 Issue: 170 Pages: 79-81
- DOI
  10.5983/nl2008jsce.46.79
- NAID
  130007854007
- ISSN
  1882-6636, 1882-6644
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06751
[Journal Article] Stem cell signaling pathways in the small intestine2020
- Author(s)
  Takahashi T. and Shiraishi A.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 6 Pages: 1-18
- DOI
  10.3390/ijms21062032
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07495, KAKENHI-PROJECT-20K06751
[Journal Article] Upregulated nicotinic ACh receptor signaling contributes to intestinal stem cell function through activation of Hippo and Notch signaling pathways2020
- Author(s)
  Takahashi Toshio、Shiraishi Akira、Osawa Masatake
- Journal Title
  
  International Immunopharmacology
  
  Volume: 88 Pages: 106984-106984
- DOI
  10.1016/j.intimp.2020.106984
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08770, KAKENHI-PROJECT-20K06751
[Journal Article] 非神経細胞型アセチルコリン受容体を介した腸幹細胞の分化・増殖制御機構の解明2020
- Author(s)
  高橋俊雄
- Journal Title
  
  Precision Medicine
  
  Volume: 3 Pages: 88-91
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06751
[Journal Article] Comparative Aspects of Structure and Function of Cnidarian Neuropeptides2020
- Author(s)
  Toshio Takahashi
- Journal Title
  
  Front. Endocrinol.
  
  Volume: 11 Pages: 339-339
- DOI
  10.3389/fendo.2020.00339
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06751
[Journal Article] Identification of neuropeptides in gastropod mollusks. Classical and brand-new approaches2020
- Author(s)
  F Morishita, T Takahashi, T Watanabe, T Uto, K Ukena, M Furumitsu and T Horiguchi
- Journal Title
  
  IOP Conf. Ser.: Earth and Environ. Sci.
  
  Volume: 456 Issue: 1 Pages: 012001-012001
- DOI
  10.1088/1755-1315/456/1/012001
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06751
[Journal Article] Organoids for Drug Discovery and Personalized Medicine2019
- Author(s)
  Takahashi T.
- Journal Title
  
  Annu. Rev. Pharmacol. Toxicol.
  
  Volume: 59 Issue: 1 Pages: 447-462
- DOI
  10.1146/annurev-pharmtox-010818-021108
- Data Source
  KAKENHI-PROJECT-17K07495
[Journal Article] New trends and perspectives in the function of non-neuronal acetylcholine in crypt-villus organoids in mice2019
- Author(s)
  Takahashi T.
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 1576 Pages: 145-155
- DOI
  10.1007/7651_2016_1
- ISBN
  9781493976164, 9781493976171
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K07495
[Journal Article] 非神経性アセチルコリンによる腸幹細胞の分化・増殖、維持機構の解明2019
- Author(s)
  高橋俊雄
- Journal Title
  
  Medical Science Digest
  
  Volume: 45 Pages: 41-43
- Data Source
  KAKENHI-PROJECT-17K07495
[Journal Article] The coordinated activities of nAChR and Wnt signaling regulate intestinal stem cell function in mice.2018
- Author(s)
  Toshio Takahashi, Akira Shiraishi, and Jun Murata
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 19 Issue: 3 Pages: 738-738
- DOI
  10.3390/ijms19030738
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07495
[Journal Article] New trends and perspectives in the function of non-neuronal acetylcholine in crypt-villus organoids in mice2017
- Author(s)
  Takahashi, T
- Journal Title
  
  Methods Mol. Biol.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26440184
[Journal Article] Visualization of acetylcholine distribution in intestinal tissue sections by tandem imaging mass spectrometry and its function in mice.2017
- Author(s)
  Toshio Takahashi
- Journal Title
  
  J. Neurochem.
  
  Volume: 142 Pages: 203-204
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07495
[Journal Article] 多段階質量分析イメージングによる腸上皮組織中のアセチルコリン分布とその役割2016
- Author(s)
  高橋
- Journal Title
  
  比較内分泌学
  
  Volume: 42 Pages: 49-50
- NAID
  130005158041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26440184
[Journal Article] 「CompBiol 2015 合同シンポジウム」”ホストオミクス時代における画像解析の最前線”顛末記2016
- Author(s)
  高橋
- Journal Title
  
  比較生理生化学
  
  Volume: 33 Pages: 22-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26440184
[Journal Article] Non-neuronal functions of acetylcholine via muscarinic receptor subtypes: cellular proliferation and differentiation in mammals2015
- Author(s)
  Toshio Takahashi
- Journal Title
  
  Neurotransmitter
  
  Volume: 2
- DOI
  10.14800/nt.499
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26440184
[Journal Article] Insight into the molecular and functional diversity of cnidarian neuropeptides.2015
- Author(s)
  Takahashi T, Takeda N.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 16 Issue: 2 Pages: 10-25
- DOI
  10.3390/ijms16022610
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26840073, KAKENHI-PROJECT-26440184
[Journal Article] Non-neuronal acetylcholine as an endogenous regulator of proliferation and differentiation of Lgr5-positive stem cells in mice2014
- Author(s)
  Toshio Takahashi, Hiroe Ohnishi, Yuki Sugiura, Kurara Honda, Makoto Suematsu, Takashi Kawasaki, Tomonori Deguchi, Takeshi Fujii, Kaoru Orihashi, Yoshitaka Hippo, Takehiro Watanabe, Tohro Yamagaki and Shunsuke Yuba
- Journal Title
  
  the FEBS J
  
  Volume: 281 Issue: 20 Pages: 4672-4690
- DOI
  10.1111/febs.12974
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26440184, KAKENHI-PROJECT-26560469
[Journal Article] Neuropeptides and their functions in Hydra2008
- Author(s)
  Toshio Takahashi
- Journal Title
  
  Acta Biologica Hungarica 59
  
  Pages: 227-235
- Data Source
  KAKENHI-PROJECT-18770054
[Journal Article] Molecular and functional characterization of a novel gonadotropin-releasing-hormone receptor isolated from the common octopus (Octopus vulgaris)2006
- Author(s)
  A.Kanda, T.Takahashi, H.Satake, H.Minakata
- Journal Title
  
  Biochem. J. 395
  
  Pages: 125-135
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15207007
[Journal Article] Cloning and distribution of the bullfrog type 1 and type 2 corticotropin-releasing factor receptors.2006
- Author(s)
  Y.Ito, R.Okada, N.Takahashi, S.Kikuyama
- Journal Title
  
  Gen. Comp. Endocrinol. 146
  
  Pages: 291-295
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15207007
[Journal Article] Civelli Salusin (beta) is a surrogate ligand of the mas-like G protein-coupled receptor MrgAl.2006
- Author(s)
  Z.Wang, T.Takahashi, Y.Saito, H.Nagasaki, N.K.Ly, H.-P.Nothacker, R.K.Reinscheid, J.Yang, J.K.Chang, M.Shichiri, 0.
- Journal Title
  
  Eur. J. Pharmacol. 539
  
  Pages: 145-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15207007
[Journal Article] New perspectives on neuropeptides in Hydra.2006
- Author(s)
  T.Takahashi, E.Hayakawa, O.Koizumi, T.Fujisawa
- Journal Title
  
  Invertebrate Neuropeptides and Hormones : Basic Knowledge and Recent Advances (H. Satake (ed)) (Transworld Research Network, India)
  
  Pages: 1-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15207007
[Journal Article] Molecular cloning and functional characterization of a prolactin-releasing peptide homolog from Xenopus laevis.2006
- Author(s)
  T.Sakamoto, A.Oda, K.Yamamoto, M.Kaneko, S.Kikuyama, A.Nishikawa, A.Takahashi, H.Kawauchi, K.Tsutsui, M.Fujimoto
- Journal Title
  
  Peptides 27
  
  Pages: 3347-3351
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15207007
[Journal Article] Hym-301, a novel peptide, regulates the number of tentacles formed in hydra.2005
- Author(s)
  T.Takahashi
- Journal Title
  
  Development (In press)
- Data Source
  KAKENHI-PROJECT-15207007
[Journal Article] Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks.2005
- Author(s)
  T.Tachibana, M.Sato, H.Takahashi, K.Ukena, K.Tsutsui, M.Furuse
- Journal Title
  
  Brain Res. 1050
  
  Pages: 94-100
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15207007
[Journal Article] Hym-301, a novel peptide, regulates the number of tentacles formed in hydra.2005
- Author(s)
  T.Takahashi, M.Hatta, S.Yum, 0.Koizumi, Y.Kobayakawa, L.Gee, M.Ohtani, T.Fujisawa, H.R.Bode
- Journal Title
  
  Development 132
  
  Pages: 2225-2234
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15207007
[Journal Article] Systematic identification of peptide signaling molecules by combining Hydra peptide and EST projects.2005
- Author(s)
  T.Fujisawa, E.Hayakawa, T.Takahashi
- Journal Title
  
  Peptide Science 2004 (Y. Shimohigashi (ed)) (The Japanese Peptide Society (Japan))
  
  Pages: 21-24
- NAID
  10014459486
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15207007
[Journal Article] Hym-301, a novel peptide, regulates the number of tentacles formed in hydra.2005
- Author(s)
  T.Takahashi et al.
- Journal Title
  
  Development 132
  
  Pages: 2225-2234
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15207007
[Journal Article] Hym-301, a novel peptide, regulates the number of tentacles formed in hydra.2005
- Author(s)
  T.Takahashi
- Journal Title
  
  Development 132
  
  Pages: 2225-2234
- Data Source
  KAKENHI-PROJECT-15207007
[Journal Article] Identification of a new member of the LWamide peptide family.2003
- Author(s)
  T.Takahashi et al.
- Journal Title
  
  Comp. Biochem. Physiol. Part B 135
  
  Pages: 309-324
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15207007
[Journal Article] Identification of a new member of the LWamide peptide family.2003
- Author(s)
  T.Takahashi, Y.Kobayakawa, Y.Muneoka, Y.Fujisawa, S.Mohri, M.Hatta, H.Shimizu, T.Fujisawa, T.Sugiyama, M.Takahara, K.Yanagi, 0.Koizumi
- Journal Title
  
  Comp. Biochem. Physiol. Part B 135
  
  Pages: 309-324
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15207007
[Presentation] The coordinated activities of nicotinic acetylcholine receptor and Wnt signaling regulate intestinal stem cell function in mice2023
- Author(s)
  高橋俊雄、高瀬悠太
- Organizer
  日本発生生物学会
- Data Source
  KAKENHI-PROJECT-23K05862
[Presentation] 腸幹細胞の幹細胞性を支えるアセチルコリンシグナリング2023
- Author(s)
  高橋俊雄、高瀬悠太
- Organizer
  日本比較内分泌学会
- Data Source
  KAKENHI-PROJECT-23K05862
[Presentation] 腸の活発な再生・分化を支える非神経性アセチルコリンシグナリング2022
- Author(s)
  高橋俊雄
- Organizer
  日本比較内分泌学会
- Invited
- Data Source
  KAKENHI-PROJECT-20K06751
[Presentation] 代謝型ムスカリン性ACh受容体M3は、EphB/ephrin-Bシグナリングを介して腸上皮幹細胞の維持に貢献する2022
- Author(s)
  高橋俊雄
- Organizer
  日本発生生物学会
- Data Source
  KAKENHI-PROJECT-20K06751
[Presentation] Structure and function of Hydra neuropeptides2019
- Author(s)
  Takahashi T.
- Organizer
  The 10th International Congress of Comparative Physiology and Biochemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07495
[Presentation] The coordinated activities of nAChR and Wnt signaling regulate intestinal stem cell function in mice2019
- Author(s)
  Takahashi T, Shiraishi A, Murata J.
- Organizer
  日本比較生理生化学会
- Data Source
  KAKENHI-PROJECT-17K07495
[Presentation] The α2β4 nicotinic acetylcholine receptor controls intestinal stem cell proliferation and differentiation in mice2019
- Author(s)
  Takahashi T, Shiraishi A, Murata J.
- Organizer
  5th International Symposium on Non-neuronal Acetylcholine: from bench to bedside
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07495
[Presentation] 非神経性アセチルコリンが制御する腸幹細胞の分化・増殖、維持機構の解明2018
- Author(s)
  高橋俊雄
- Organizer
  星薬科大学セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K07495
[Presentation] チャネル型ニコチン性アセチルコリン受容体を介した腸上皮幹細胞の制御2018
- Author(s)
  高橋俊雄, 白石慧, 村田純
- Organizer
  日本比較内分泌学会
- Data Source
  KAKENHI-PROJECT-17K07495
[Presentation] チャネル型nAChRシグナルはWntシグナルを介して腸上皮幹細胞を制御する2018
- Author(s)
  高橋俊雄, 白石慧, 村田純
- Organizer
  日本動物学会
- Data Source
  KAKENHI-PROJECT-17K07495
[Presentation] Intestinal stem cell homeostasis via muscarinic acetylcholine receptors2018
- Author(s)
  高橋俊雄
- Organizer
  日本比較生理生化学会
- Data Source
  KAKENHI-PROJECT-17K07495
[Presentation] 代謝型ムスカリン性ACh受容体を介した腸上皮幹細胞の恒常性維持機構2018
- Author(s)
  高橋俊雄
- Organizer
  第4回NAIST-SUNBOR最先端融合セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K07495
[Presentation] 非神経性アセチルコリンが制御する組織幹細胞の分化・増殖、維持機構の解明2018
- Author(s)
  高橋俊雄
- Organizer
  第３回NAIST-SUNBOR 最先端融合セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K07495
[Presentation] 非神経性アセチルコリンが制御する組織幹細胞の分化・増殖、維持機構の解明2018
- Author(s)
  高橋俊雄
- Organizer
  第3回NAIST-SUNBOR最先端融合セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-17K07495
[Presentation] Non-neuronal functions of acetylcholine via muscarinic receptor subtypes: Intestinal stem cell proliferation and differentiation2016
- Author(s)
  Takahashi, T
- Organizer
  第２２回国際動物学会会議・日本動物学会８７回大会合同大会
- Place of Presentation
  沖縄
- Year and Date
  2016-11-14
- Data Source
  KAKENHI-PROJECT-26440184
[Presentation] Visualization of acetylcholine distribution in intestinal tissue sections by tandem imaging mass spectrometry and its function in mice2016
- Author(s)
  Takahashi, T
- Organizer
  XVth International Symposium on Cholinergic Mechanisms
- Place of Presentation
  Marseille, France
- Year and Date
  2016-10-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26440184
[Presentation] 腸上皮から放出されるアセチルコリンによる腸上皮幹細胞の分化・増殖制御2015
- Author(s)
  高橋俊雄
- Organizer
  日本動物学会
- Place of Presentation
  新潟
- Year and Date
  2015-09-17
- Data Source
  KAKENHI-PROJECT-26440184
[Presentation] 多段階質量分析イメージングによる腸上皮組織中のアセチルコリン分布とその役割2015
- Author(s)
  高橋俊雄
- Organizer
  日本比較内分泌学会大会・日本比較生理生化学会　合同大会
- Place of Presentation
  広島
- Year and Date
  2015-12-11
- Invited
- Data Source
  KAKENHI-PROJECT-26440184
[Presentation] ヒドラの発生制御に関与するペプチド性シグナル分子-神経分化、触手形成を中心に-2007
- Author(s)
  高橋俊雄
- Organizer
  奈良先端科学技術大学院大学GCOEセミナー
- Place of Presentation
  奈良先端科学技術大学院大学
- Year and Date
  2007-10-10
- Data Source
  KAKENHI-PROJECT-18770054
[Presentation] 同一遺伝子上にコードされたヒドラ新規神経ペプチドの向筋作用2007
- Author(s)
  高橋俊雄
- Organizer
  第32回日本比較内分泌学会大会
- Place of Presentation
  日光、栃木
- Year and Date
  2007-10-12
- Data Source
  KAKENHI-PROJECT-18770054
[Presentation] Evolutionary implication of the cholinergic system in the Cnidaria: Itsrole in regulation of the developmental processes in Hydra2007
- Author(s)
  Toshio Takahashi
- Organizer
  International Workshop HYDRA AND THE DEVELOPMENT OF ANIMAL FORM
- Place of Presentation
  Tutzing, Germany
- Year and Date
  2007-09-19
- Data Source
  KAKENHI-PROJECT-18770054
[Presentation] Neuropeptides and their functions in Hydra2007
- Author(s)
  Toshio Takahashi
- Organizer
  ISIN, 11th Symposium on Invertebrate Neurobiology
- Place of Presentation
  Tihany, Hungary
- Year and Date
  2007-08-28
- Data Source
  KAKENHI-PROJECT-18770054
[Presentation] Non-neuronal acetylcholine is an endogenous regulator of proliferation and differentiation of Lfr5-positive stem cells in mouse gut
- Author(s)
  Takahashi T, Ohnishi H, Sugiura Y, Honda K, Suematsu M, Kawasaki T, Deguchi T, Fujii T, Orihashi K, Hippo Y, Watanabe T, Yamagaki T and Yuba S
- Organizer
  4th International Symposium on Non-neuronal Acetylcholine
- Place of Presentation
  Giessen, Germany
- Year and Date
  2014-08-28 – 2014-08-30
- Data Source
  KAKENHI-PROJECT-26440184
[Presentation] Non-neuronal acetylcholine as an endogenous regulator of proliferation and differentiation of Lgr5-positive stem cells in mice
- Author(s)
  高橋、大西、杉浦、本多、末松、川崎、出口、藤井、折橋、筆宝、渡辺、山垣、弓場
- Organizer
  日本比較生理生化学会
- Place of Presentation
  札幌
- Year and Date
  2014-07-28 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-26440184
[Presentation] 腸幹細胞システムを制御する非神経性アセチルコリンの役割
- Author(s)
  高橋、大西、杉浦、本多、末松、川崎、出口、藤井、折橋、筆宝、渡辺、山垣、弓場
- Organizer
  日本発生生物学会
- Place of Presentation
  名古屋
- Year and Date
  2014-05-27 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-26440184

1. MINAKATA Hiroyuki (90150143)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. YUBA Shunsuke (40263248)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. SUEMATSU Makoto (00206385)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. TSUTSUI Kazuyoshi (20163842)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. KIKUYAMA Sakae (20063638)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. UKENA Kazuyoshi (10304370)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. Murata Yoshiko (60256047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAMBA KOSUKE (50414123)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KIMURA HIROYUKI (50437240)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMAGAKI TOHRU (40313209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. TSUGAWA Hitoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. MITA Masatoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. TAKEDA Noriyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 松尾亮太

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 高瀬悠太

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 菊山榮

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 大沢匡毅

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

TAKAHASHI TOSHIO 高橋 俊雄

高橋 俊雄 タカハシ トシオ

TAKAHASHI Toshio 高橋 俊雄

Research Projects

Research Products

Co-Researchers

Elucidation of acetylcholine signaling in aid of intestinal stem cell stemnessPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of regulatory mechanism of intestinal stem cell proliferation and differentiation via non-neuronal acetylcholine receptorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of regulatory mechanism of non-neuronal acetylcholine as an endogenous regulator of proliferation, differentiation, and maintenance of intestinal stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of a novel physiological function of acetylcholine in gut epitheliumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of iron chelator nicotianamine from plant food on iron absorption in intestine

Principal Investigator

Project Period (FY)

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Research Institution

ヒドラの生体制御に関与するペプチド性シグナル分子とその受容体の網羅的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Expression and distribution of novel peptidehormones in memory and learning system of cephalopod brain

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of the synthesis and release of pituitary hormones by novel hypothalamic neurohormones

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Medical Science Digest2023

Author(s)

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Data Source

[Book] BIO Clinica2021

Author(s)

Total Pages

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[Book] Advances Invertebrate (Neuro)Endocrinology2020

Author(s)

Total Pages

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ISBN

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[Book] Advances Invertebrate (Neuro)Endocrinology2020

Author(s)

Total Pages

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Data Source

[Book] Advances Invertebrate (Neuro)Endocrinology2019

Author(s)

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Data Source

[Book] 質量分析でアセチルコリンを”可視化する”技2017

TAKAHASHI TOSHIO 高橋俊雄

高橋俊雄タカハシトシオ

TAKAHASHI Toshio 高橋俊雄

[Book] 「研究者が教える動物実験」　生理活性ペプチドを“見つける”技2015