Shiizaki Kazuhiro 椎崎一宏

… Alternative Names

SHIIZAKI Kazuhiro 椎崎一宏

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Researcher Number	20391112
Other IDs	https://orcid.org/0000-0001-8257-0952
Affiliation (Current)	2025: 東洋大学, 生命科学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 東洋大学, 生命科学部, 教授 2015 – 2017: 東洋大学, 生命科学部, 准教授 2013: 独立行政法人国立がん研究センター, 研究所, 研究員 2011 – 2012: 埼玉県立がんセンター(臨床腫瘍研究所), その他部局等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology / Environmental pharmacy
Keywords	Principal Investigator AhR / RAG-1 / 胎児免疫寛容 / RAG-2 / AhRリガンド / 盲腸発がん / Kynurenine / RAG2 / キヌレニン / 免疫寛容 … More / IL-6 / IDO / 第三世代シーケンサー / 一分子検出 / 第三世代シークエンサー / 次世代シークエンサー / 変異原物質 / DNA付加体 / 盲腸内容物 / βカテニン / 盲腸 / CUL4B / リガンド / 大腸がん / β-catenin Less

Study on immune evasion mechanism of tumor by AhR and its ligandsPrincipal Investigator
- Principal Investigator
  
  Shiizaki Kazuhiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Toyo University
Development of a method to identify single molecule adducts generated on genomic DNAPrincipal Investigator
- Principal Investigator
  
  Shiizaki Kazuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Toyo University
Investigation of AhR ligand for the new pharmacotherapy for prevention of colorectal cancerPrincipal Investigator
- Principal Investigator
  
  SHIIZAKI Kazuhiro
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Environmental pharmacy
- Research Institution
  National Center of Neurology and Psychiatry
  Research Institute for Clinical Oncology, Saitama Cancer Center

All 2021 2020 2019 2017 2016 2015 2014 2013 2012

All Journal Article Presentation Patent

[Journal Article] Comprehensive analysis of DNA adducts (DNA adductome analysis) in the liver of rats treated with 1,4-dioxane2020
- Author(s)
  TOTSUKA Yukari、MAESAKO Yuya、ONO Hanako、NAGAI Momoko、KATO Mamoru、GI Min、WANIBUCHI Hideki、FUKUSHIMA Shoji、SHIIZAKI Kazuhiro、NAKAGAMA Hitoshi
- Journal Title
  
  Proceedings of the Japan Academy, Series B
  
  Volume: 96 Issue: 5 Pages: 180-187
- DOI
  10.2183/pjab.96.015
- NAID
  130007841511
- ISSN
  0386-2208, 1349-2896
- Year and Date
  2020-05-11
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07697, KAKENHI-PROJECT-20K10431, KAKENHI-PROJECT-18K09146
[Journal Article] Construction of reporter gene assays using CWP and PDR mutant yeasts for enhanced detection of various sex steroids2020
- Author(s)
  Ito-Harashima Sayoko、Matano Mami、Onishi Kana、Nomura Tomofumi、Nakajima Saki、Ebata Shingo、Shiizaki Kazuhiro、Kawanishi Masanobu、Yagi Takashi
- Journal Title
  
  Genes and Environment
  
  Volume: 42 Issue: 1 Pages: 933-933
- DOI
  10.1186/s41021-020-00159-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07697
[Journal Article] Postlabeling/PAGE Method for Detection of DNA Adducts2020
- Author(s)
  Shiizaki Kazuhiro
- Journal Title
  
  Methods in molecular biology
  
  Volume: 1 Pages: 213-226
- DOI
  10.1007/978-1-0716-0323-9_18
- ISBN
  9781071603222, 9781071603239
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07697
[Journal Article] Insight into the relationship between aryl-hydrocarbon receptor and β-catenin in human colon cancer cells2019
- Author(s)
  Shiizaki Kazuhiro、Kido Kenta、Mizuta Yasuhiro
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 11 Pages: e0224613-e0224613
- DOI
  10.1371/journal.pone.0224613
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07697
[Journal Article] Influence of GSH S-transferase on the mutagenicity induced by dichloromethane and 1,2-dichloropropane2017
- Author(s)
  N Akiba, K Shiizaki, Y Matsushima, O Endo, K Inaba and Y Totsuka
- Journal Title
  
  Mutagenesis
  
  Volume: 32 Issue: 4 Pages: 455-462
- DOI
  10.1093/mutage/gex014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460469, KAKENHI-PROJECT-15K06849
[Journal Article] Modulation of benzo[a]pyrene-DNA adduct formation by CYP1 inducer and inhibitor2017
- Author(s)
  Kazuhiro Shiizaki, Masanobu Kawanishi; Takashi Yagi
- Journal Title
  
  Genes and Environment
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06849
[Journal Article] Modulation of benzo[a]pyrene-DNA adduct formation by CYP1 inducer and inhibitor2017
- Author(s)
  Shiizaki Kazuhiro、Kawanishi Masanobu、Yagi Takashi
- Journal Title
  
  Genes Environ.
  
  Volume: 39 Issue: 1 Pages: 1-8
- DOI
  10.1186/s41021-017-0076-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06849
[Journal Article] Construction of sensitive reporter assay yeasts for comprehensive detection of ligand activities of human corticosteroid receptors through inactivation of CWP and PDR genes2015
- Author(s)
  Ito-Harashima S, Shiizaki K, Kawanishi M, Kakiuchi K, Onishi K, Yamaji R, Yagi T.
- Journal Title
  
  Journal of pharmacological and toxicological methods
  
  Volume: 74:41-52. Pages: 41-52
- DOI
  10.1016/j.vascn.2015.06.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06849
[Journal Article] Identification of amino Acid residues in the ligand-binding domain of the aryl hydrocarbon receptor causing the species-specific response to omeprazole : possible determinants for binding putative endogenous ligands2014
- Author(s)
  Shiizaki K., Ohsako S., Kawanishi M., Yagi T
- Journal Title
  
  Mol Pharmacol
  
  Volume: 85(2) Pages: 279-289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590162
[Journal Article] Development of yeast reporter assay for screening specific ligands of retinoic acid and retinoid X receptor subtypes2014
- Author(s)
  Shiizaki K., Yoshikawa T., Takada E., Hirose S., Ito-Harashima S., Kawanishi M., Yagi T
- Journal Title
  
  Journal of Pharmacological and Toxicological Methods
  
  Volume: 69 (3) Pages: 245-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590162
[Journal Article] Identification of amino acid residues in the ligand-binding domain of the aryl hydrocarbon receptor causing the species-specific response to omeprazole: possible determinants for binding putative endogenous ligands.2014
- Author(s)
  Shiizaki K, Ohsako S, Kawanishi M, Yagi T.
- Journal Title
  
  Mol Pharmacol.
  
  Volume: 85 Pages: 279-289
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590162
[Journal Article] Development of yeast reporter assay for screening specific ligands of retinoic acid and retinoid X receptor subtypes.2014
- Author(s)
  Shiizaki K, Yoshikawa T, Takada E, Hirose S, Ito-Harashima S, Kawanishi M, Yagi T.
- Journal Title
  
  J Pharmacol Toxicol Methods.
  
  Volume: 69 Pages: 245-252
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590162
[Journal Article] ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice2013
- Author(s)
  Ikuta T., Kobayashi Y., Kitazawa M., Shiizaki K., Itano N., Noda T., Pettersson S., Poellinger L., Fujii-Kuriyama Y., Taniguchi S., Kawajiri K
- Journal Title
  
  Carcinogenesis
  
  Volume: 34(7) Pages: 1620-1627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590162
[Journal Article] Dioxin suppresses benzo[a]pyrene-induced mutations and DNA adduct formation through cytochrome P450 1A1 induction and (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide inactivation in human hepatoma cells.2013
- Author(s)
  Shiizaki K, Kawanishi M, Yagi T.
- Journal Title
  
  Mutation Research
  
  Volume: 750 Issue: 1-2 Pages: 77-85
- DOI
  10.1016/j.mrgentox.2012.09.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590162
[Journal Article] ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice2013
- Author(s)
  Togo Ikuta
- Journal Title
  
  Carcinogenesis
  
  Volume: 印刷中 Issue: 7 Pages: 1620-1627
- DOI
  10.1093/carcin/bgt083
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501001, KAKENHI-PROJECT-23590162, KAKENHI-PROJECT-23590566, KAKENHI-PUBLICLY-23114509
[Journal Article] Dioxin suppresses benzo[a]pyrene-induced mutations and DNA adduct formation hrough cytochrome P450 1A1 induction and (±)-anti-benzo[a]pyrene-7,8-diol-9,10- epoxide inactivation in human hepatoma cells2013
- Author(s)
  Shiizaki K., Kawanishi M, Takashi Y
- Journal Title
  
  Mutation research
  
  Volume: 750(1-2) Pages: 77-85
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590162
[Patent] 形質転換酵母、それを用いた分析方法および分析キット2013
- Inventor(s)
  西本幸史、八木孝司、川西優喜、椎崎一宏, ほか
- Industrial Property Rights Holder
  長瀬産業株式会社大阪府立大学
- Acquisition Date
  2013-03-22
- Overseas
- Data Source
  KAKENHI-PROJECT-23590162
[Presentation] 汎用除草剤ブロマシルの AhR リガンド様作用2021
- Author(s)
  小池芽生、軽部梨香子、小松升和、金丸咲葵、原島小夜子、川西優喜、八木孝司、椎崎一宏
- Organizer
  日本環境変異原学会第50回大会
- Data Source
  KAKENHI-PROJECT-19K07697
[Presentation] 「転写共役DNA修復（TCR）を考慮した変異原性試験の構築」2019
- Author(s)
  芝田幸平、椎崎一宏
- Organizer
  日本環境変異原学会第48回大会
- Data Source
  KAKENHI-PROJECT-19K07697
[Presentation] 「ヒト生体異物受容体 CAR のリガンドを検出する酵母レポーターアッセイ系の確立」2019
- Author(s)
  原島小夜子、椎崎一宏、川西優喜、八木孝司
- Organizer
  日本環境変異原学会第48回大会
- Data Source
  KAKENHI-PROJECT-19K07697
[Presentation] DNA付加体形成部位の同定に関する新規アプローチ2017
- Author(s)
  椎崎一宏
- Organizer
  16 回分子予防環境医学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-15K06849
[Presentation] 次世代シークエンサーと DNA アダクトーム解析の統合による発がん要因の探索2017
- Author(s)
  前迫侑也、善家茜、エルザワハリアスマ、古川英作、加藤護、白石航也、河野隆志、椎崎一宏、戸塚ゆ加里
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-15K06849
[Presentation] DNA付加体形成部位の同定に関する新規アプローチ2017
- Author(s)
  椎崎一宏
- Organizer
  第16 回分子予防環境医学研究会シンポジウム
- Place of Presentation
  熊本市国際交流会館（熊本県熊本市）
- Year and Date
  2017-02-03
- Invited
- Data Source
  KAKENHI-PROJECT-15K06849
[Presentation] 生体を模倣したナノマテリアルの新規毒性評価システムの確立2017
- Author(s)
  神尾翔真、斎藤春五、渡邉昌俊、椎崎一宏、戸塚ゆ加里
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-15K06849
[Presentation] 職業性胆管がん発生に関与する1,2- ジクロロプロパンのDNA 付加体の網羅的な解析（アダクトーム解析）2016
- Author(s)
  前迫侑也、善家茜、古川英作、加藤護、椎崎一宏、中釜斉、戸塚ゆ加里
- Organizer
  日本環境変異原学会第45回大会
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-15K06849
[Presentation] 複数の化学物質曝露による遺伝毒性　－核内受容体と薬物代謝酵素による毒性の修飾－2015
- Author(s)
  椎崎一宏
- Organizer
  日本環境変異原学会第44回大会
- Place of Presentation
  九州大学馬出キャンパス　コラボ・ステーション(福岡県福岡市)
- Year and Date
  2015-11-27
- Invited
- Data Source
  KAKENHI-PROJECT-15K06849
[Presentation] アリール炭化水素受容体（AhR）とキヌレニン経路でのトリプトファン代謝2013
- Author(s)
  椎崎一宏
- Organizer
  第26回　変異機構研究会
- Place of Presentation
  アイプラザ一宮（愛知県）
- Data Source
  KAKENHI-PROJECT-23590162
[Presentation] アリール炭化水素受容体(AhR)とキヌレニン経路でのトリプトファン代謝2013
- Author(s)
  椎崎一宏
- Organizer
  変異機構研究会第26回夏の学校
- Place of Presentation
  愛知県一宮市アイプラザ一宮
- Data Source
  KAKENHI-PROJECT-23590162
[Presentation] アリール炭化水素受容体(AhR)とキヌレニン経路でのトリプトファン代謝2012
- Author(s)
  椎崎一宏
- Organizer
  変異機構研究会第25回夏の学校
- Place of Presentation
  愛知県小牧市小牧勤労センター
- Data Source
  KAKENHI-PROJECT-23590162
[Presentation] アリール炭化水素受容体AhRとキヌレニン経路でのトリプトファン代謝との関係2012
- Author(s)
  椎崎一宏
- Organizer
  日本環境変異原学会　第25回変異機構研究会
- Place of Presentation
  小牧勤労センター
- Data Source
  KAKENHI-PROJECT-23590162

1. IKUTA Togo (00262072)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. KAWAJIRI Kaname (50142112)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. TOTSUKA Yukari (40373401)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. 松島芳隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shiizaki Kazuhiro 椎崎 一宏

SHIIZAKI Kazuhiro 椎崎 一宏

Research Projects

Research Products

Co-Researchers

Study on immune evasion mechanism of tumor by AhR and its ligandsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a method to identify single molecule adducts generated on genomic DNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of AhR ligand for the new pharmacotherapy for prevention of colorectal cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Comprehensive analysis of DNA adducts (DNA adductome analysis) in the liver of rats treated with 1,4-dioxane2020

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Construction of reporter gene assays using CWP and PDR mutant yeasts for enhanced detection of various sex steroids2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Postlabeling/PAGE Method for Detection of DNA Adducts2020

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Insight into the relationship between aryl-hydrocarbon receptor and β-catenin in human colon cancer cells2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Influence of GSH S-transferase on the mutagenicity induced by dichloromethane and 1,2-dichloropropane2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Modulation of benzo[a]pyrene-DNA adduct formation by CYP1 inducer and inhibitor2017

Author(s)

Journal Title

Data Source

[Journal Article] Modulation of benzo[a]pyrene-DNA adduct formation by CYP1 inducer and inhibitor2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Construction of sensitive reporter assay yeasts for comprehensive detection of ligand activities of human corticosteroid receptors through inactivation of CWP and PDR genes2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of amino Acid residues in the ligand-binding domain of the aryl hydrocarbon receptor causing the species-specific response to omeprazole : possible determinants for binding putative endogenous ligands2014

Author(s)

Journal Title

Data Source

[Journal Article] Development of yeast reporter assay for screening specific ligands of retinoic acid and retinoid X receptor subtypes2014

Author(s)

Journal Title

Data Source

[Journal Article] Identification of amino acid residues in the ligand-binding domain of the aryl hydrocarbon receptor causing the species-specific response to omeprazole: possible determinants for binding putative endogenous ligands.2014

Author(s)

Journal Title

Data Source

[Journal Article] Development of yeast reporter assay for screening specific ligands of retinoic acid and retinoid X receptor subtypes.2014

Shiizaki Kazuhiro 椎崎一宏

SHIIZAKI Kazuhiro 椎崎一宏

[Presentation] 複数の化学物質曝露による遺伝毒性　－核内受容体と薬物代謝酵素による毒性の修飾－2015